GGT3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.75275907
2response to pheromone (GO:0019236)5.70167970
3positive regulation of action potential (GO:0045760)5.42780385
4gamma-aminobutyric acid transport (GO:0015812)4.82586631
5establishment of protein localization to Golgi (GO:0072600)4.81173645
6protein targeting to Golgi (GO:0000042)4.80967378
7fusion of sperm to egg plasma membrane (GO:0007342)4.64925128
8presynaptic membrane assembly (GO:0097105)4.60880720
9microtubule depolymerization (GO:0007019)4.58885890
10sperm motility (GO:0030317)4.58583517
11retrograde transport, vesicle recycling within Golgi (GO:0000301)4.38867960
12glial cell proliferation (GO:0014009)4.33447236
13histone H3-K9 demethylation (GO:0033169)4.18998897
14protein localization to Golgi apparatus (GO:0034067)4.18463906
15male meiosis I (GO:0007141)4.13656029
16somite rostral/caudal axis specification (GO:0032525)4.04901427
17negative regulation of gene silencing (GO:0060969)4.03541244
18spermatid development (GO:0007286)3.96072719
19cerebral cortex neuron differentiation (GO:0021895)3.92802062
20postsynaptic membrane organization (GO:0001941)3.91141633
21seminiferous tubule development (GO:0072520)3.91079524
22cilium or flagellum-dependent cell motility (GO:0001539)3.89902582
23tachykinin receptor signaling pathway (GO:0007217)3.89377276
24limb bud formation (GO:0060174)3.88256633
25DNA methylation involved in gamete generation (GO:0043046)3.88210560
26piRNA metabolic process (GO:0034587)3.83941209
27pyrimidine nucleobase catabolic process (GO:0006208)3.82128507
28thyroid hormone generation (GO:0006590)3.81330511
29cellular ketone body metabolic process (GO:0046950)3.78153743
30plasma membrane fusion (GO:0045026)3.73226379
31calcium ion-dependent exocytosis (GO:0017156)3.72941923
32negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.66454763
33regulation of cilium movement (GO:0003352)3.65004345
34forebrain neuron differentiation (GO:0021879)3.57988102
35presynaptic membrane organization (GO:0097090)3.56106754
36spermatid nucleus differentiation (GO:0007289)3.53382610
37male meiosis (GO:0007140)3.51255261
38microtubule polymerization or depolymerization (GO:0031109)3.50214824
39thyroid gland development (GO:0030878)3.42723587
40synaptic transmission, cholinergic (GO:0007271)3.42168422
41neural tube formation (GO:0001841)3.39217579
42ketone body metabolic process (GO:1902224)3.36407940
43positive regulation of Rab GTPase activity (GO:0032851)3.36383982
44regulation of Rab GTPase activity (GO:0032313)3.36383982
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27899924
46positive regulation of mitochondrial fission (GO:0090141)3.23615654
47multicellular organism reproduction (GO:0032504)3.18832761
48regulation of action potential (GO:0098900)3.18745349
49peroxisome fission (GO:0016559)3.16047454
50regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.14835535
51nucleobase catabolic process (GO:0046113)3.12153287
52acrosome assembly (GO:0001675)3.07759440
53axonemal dynein complex assembly (GO:0070286)3.07525288
54sperm-egg recognition (GO:0035036)3.07297066
55intra-Golgi vesicle-mediated transport (GO:0006891)3.06524921
56thyroid hormone metabolic process (GO:0042403)3.03070795
57reflex (GO:0060004)3.02786531
58glycine transport (GO:0015816)3.02466953
59protein localization to cilium (GO:0061512)3.02416434
60positive regulation of vesicle fusion (GO:0031340)3.01918123
61regulation of hippo signaling (GO:0035330)3.01565359
62neuronal action potential propagation (GO:0019227)3.00971776
63regulation of glucocorticoid secretion (GO:2000849)3.00704203
64cochlea development (GO:0090102)3.00599352
65synapse assembly (GO:0007416)3.00092908
66meiosis I (GO:0007127)2.97610041
67regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.91818335
68nephron tubule formation (GO:0072079)2.91337792
69DNA integration (GO:0015074)2.91087580
70nephron tubule development (GO:0072080)2.90930841
71negative regulation of heart rate (GO:0010459)2.90004731
72protein localization to synapse (GO:0035418)2.86357892
73spermatogenesis (GO:0007283)2.85859168
74male gamete generation (GO:0048232)2.84239644
75sympathetic nervous system development (GO:0048485)2.82955110
76neurotransmitter-gated ion channel clustering (GO:0072578)2.82295514
77growth hormone receptor signaling pathway (GO:0060396)2.81888759
78negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.81204430
79calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.81132394
80sperm capacitation (GO:0048240)2.76936434
81polyol transport (GO:0015791)2.72208997
82embryonic epithelial tube formation (GO:0001838)2.70786493
83neuron cell-cell adhesion (GO:0007158)2.69903860
84meiotic nuclear division (GO:0007126)2.69885917
85central nervous system neuron axonogenesis (GO:0021955)2.67804546
86peptidyl-threonine dephosphorylation (GO:0035970)2.67454654
87one-carbon compound transport (GO:0019755)2.66207760
88histone H3-K36 demethylation (GO:0070544)2.65397284
89RNA destabilization (GO:0050779)2.63603454
90mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.63462656
91gamete generation (GO:0007276)2.63450194
92cell-cell recognition (GO:0009988)2.62370263
93mesonephros development (GO:0001823)2.61802797
94dendritic spine organization (GO:0097061)2.61507541
95reproduction (GO:0000003)2.59177581
96regulation of mitochondrial fission (GO:0090140)2.58141866
97lung secretory cell differentiation (GO:0061140)2.56662834
98regulation of transcription involved in cell fate commitment (GO:0060850)2.55918642
99regulation of microtubule-based movement (GO:0060632)2.55786114
100renal tubule development (GO:0061326)2.53744774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.71577503
2GBX2_23144817_ChIP-Seq_PC3_Human3.42495530
3IGF1R_20145208_ChIP-Seq_DFB_Human3.17702816
4EZH2_22144423_ChIP-Seq_EOC_Human2.97860077
5TAF15_26573619_Chip-Seq_HEK293_Human2.79715435
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.76728133
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.71952899
8FUS_26573619_Chip-Seq_HEK293_Human2.69882314
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.48909696
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.45835098
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44428118
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21950079
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15031132
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12800372
15VDR_22108803_ChIP-Seq_LS180_Human2.12023768
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93538524
17P300_19829295_ChIP-Seq_ESCs_Human1.87225151
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84945814
19AR_21572438_ChIP-Seq_LNCaP_Human1.80037525
20AR_25329375_ChIP-Seq_VCAP_Human1.70817168
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68224522
22CBP_20019798_ChIP-Seq_JUKART_Human1.68224522
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68036290
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67006290
25ER_23166858_ChIP-Seq_MCF-7_Human1.66310095
26SMAD4_21799915_ChIP-Seq_A2780_Human1.63645732
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61975818
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.51931364
29* STAT3_23295773_ChIP-Seq_U87_Human1.46345533
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45799008
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45611288
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44115375
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43947461
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42407645
35RNF2_27304074_Chip-Seq_NSC_Mouse1.41208723
36DROSHA_22980978_ChIP-Seq_HELA_Human1.40313188
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40125043
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40125043
39IRF1_19129219_ChIP-ChIP_H3396_Human1.40057814
40RUNX2_22187159_ChIP-Seq_PCA_Human1.38816597
41REST_21632747_ChIP-Seq_MESCs_Mouse1.38619149
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.36655915
43BCAT_22108803_ChIP-Seq_LS180_Human1.35089743
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34259164
45MYC_19829295_ChIP-Seq_ESCs_Human1.30086868
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.29991587
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28986920
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28645786
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.28399080
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28120614
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26878222
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.25341153
53* TCF4_23295773_ChIP-Seq_U87_Human1.24858416
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24209311
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.23012706
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22302886
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20641794
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.19273775
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19158336
60KDM2B_26808549_Chip-Seq_REH_Human1.18059139
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.17004433
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.15449922
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14776584
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14480055
65* EWS_26573619_Chip-Seq_HEK293_Human1.13868931
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.12952267
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.12097849
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11762088
69* TCF4_22108803_ChIP-Seq_LS180_Human1.11406763
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10539003
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10150603
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09378304
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09206262
74SMAD4_21741376_ChIP-Seq_HESCs_Human1.09134649
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.08963949
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07232300
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.06791517
78HOXB7_26014856_ChIP-Seq_BT474_Human1.05934457
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05870227
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05058794
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04959182
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04900355
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04800244
84* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03614201
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03166440
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01984287
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01808899
88TP53_18474530_ChIP-ChIP_U2OS_Human0.99805728
89* OCT4_20526341_ChIP-Seq_ESCs_Human0.99176980
90PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99159673
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97858671
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97756901
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96739337
94TP53_22573176_ChIP-Seq_HFKS_Human0.96483668
95* OCT1_27270436_Chip-Seq_PROSTATE_Human0.95461466
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94802121
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94535508
98RAC3_21632823_ChIP-Seq_H3396_Human0.94280812
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.94157278
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.93853330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.13010428
2MP0002822_catalepsy4.51633864
3MP0005410_abnormal_fertilization3.65494344
4MP0005645_abnormal_hypothalamus_physiol3.33066314
5MP0008877_abnormal_DNA_methylation3.20117334
6MP0003880_abnormal_central_pattern2.75066489
7MP0002102_abnormal_ear_morphology2.56469757
8MP0003698_abnormal_male_reproductive2.34549076
9MP0000681_abnormal_thyroid_gland2.13394490
10MP0002735_abnormal_chemical_nociception2.07267393
11MP0000013_abnormal_adipose_tissue2.03182883
12MP0004043_abnormal_pH_regulation1.93451437
13MP0003786_premature_aging1.88032740
14MP0003879_abnormal_hair_cell1.80941991
15MP0010386_abnormal_urinary_bladder1.77023618
16MP0001929_abnormal_gametogenesis1.76948070
17MP0001501_abnormal_sleep_pattern1.70725014
18MP0000383_abnormal_hair_follicle1.70345924
19MP0003183_abnormal_peptide_metabolism1.69692700
20MP0001486_abnormal_startle_reflex1.68322994
21MP0003119_abnormal_digestive_system1.64998361
22MP0003635_abnormal_synaptic_transmissio1.64117921
23MP0002876_abnormal_thyroid_physiology1.61492390
24MP0005377_hearing/vestibular/ear_phenot1.60211837
25MP0003878_abnormal_ear_physiology1.60211837
26MP0002184_abnormal_innervation1.58987738
27MP0002272_abnormal_nervous_system1.49711001
28MP0009745_abnormal_behavioral_response1.48145046
29MP0005647_abnormal_sex_gland1.47379144
30MP0006276_abnormal_autonomic_nervous1.46814588
31MP0010678_abnormal_skin_adnexa1.43767052
32MP0005646_abnormal_pituitary_gland1.42967777
33MP0000427_abnormal_hair_cycle1.41971902
34MP0004270_analgesia1.41156994
35MP0005167_abnormal_blood-brain_barrier1.38463340
36MP0004859_abnormal_synaptic_plasticity1.36192150
37MP0002210_abnormal_sex_determination1.35768948
38MP0000778_abnormal_nervous_system1.35687357
39MP0001968_abnormal_touch/_nociception1.35512608
40MP0000647_abnormal_sebaceous_gland1.34570402
41MP0000678_abnormal_parathyroid_gland1.30862580
42MP0002653_abnormal_ependyma_morphology1.30406139
43MP0001188_hyperpigmentation1.28271490
44MP0000631_abnormal_neuroendocrine_gland1.27159320
45MP0000955_abnormal_spinal_cord1.26795906
46MP0005499_abnormal_olfactory_system1.26153713
47MP0005394_taste/olfaction_phenotype1.26153713
48MP0005253_abnormal_eye_physiology1.26070074
49MP0001984_abnormal_olfaction1.23872156
50MP0000026_abnormal_inner_ear1.23036540
51MP0003718_maternal_effect1.21081734
52MP0002063_abnormal_learning/memory/cond1.17654872
53MP0002572_abnormal_emotion/affect_behav1.17514961
54MP0002736_abnormal_nociception_after1.16244777
55MP0000049_abnormal_middle_ear1.16143447
56MP0001145_abnormal_male_reproductive1.15471911
57MP0000465_gastrointestinal_hemorrhage1.14911987
58MP0001970_abnormal_pain_threshold1.14122113
59MP0002557_abnormal_social/conspecific_i1.13650848
60MP0001963_abnormal_hearing_physiology1.11532317
61MP0008789_abnormal_olfactory_epithelium1.11397912
62MP0005085_abnormal_gallbladder_physiolo1.10180245
63MP0003195_calcinosis1.09135810
64MP0002161_abnormal_fertility/fecundity1.09044321
65MP0002733_abnormal_thermal_nociception1.08603734
66MP0002909_abnormal_adrenal_gland1.08249202
67MP0000653_abnormal_sex_gland1.05699880
68MP0005248_abnormal_Harderian_gland1.05267729
69MP0002234_abnormal_pharynx_morphology1.05176705
70MP0004811_abnormal_neuron_physiology1.01666464
71MP0003115_abnormal_respiratory_system1.00285770
72MP0003221_abnormal_cardiomyocyte_apopto1.00240245
73MP0003122_maternal_imprinting0.99695212
74MP0002751_abnormal_autonomic_nervous0.98972060
75MP0001764_abnormal_homeostasis0.98947508
76MP0002067_abnormal_sensory_capabilities0.98007862
77MP0001765_abnormal_ion_homeostasis0.97503408
78MP0009697_abnormal_copulation0.97431975
79MP0002009_preneoplasia0.95225900
80MP0002064_seizures0.93760157
81MP0003787_abnormal_imprinting0.93236938
82MP0005551_abnormal_eye_electrophysiolog0.92927694
83MP0003121_genomic_imprinting0.92328137
84MP0002882_abnormal_neuron_morphology0.88699460
85MP0001348_abnormal_lacrimal_gland0.87995016
86MP0005670_abnormal_white_adipose0.87192648
87MP0002752_abnormal_somatic_nervous0.87177054
88MP0002734_abnormal_mechanical_nocicepti0.86820127
89MP0004142_abnormal_muscle_tone0.85915020
90MP0001986_abnormal_taste_sensitivity0.85660259
91MP0004085_abnormal_heartbeat0.84307464
92MP0008872_abnormal_physiological_respon0.83929768
93MP0003385_abnormal_body_wall0.81405951
94MP0004782_abnormal_surfactant_physiolog0.81022665
95MP0004742_abnormal_vestibular_system0.80212940
96MP0004134_abnormal_chest_morphology0.78207235
97MP0003646_muscle_fatigue0.76796012
98MP0000015_abnormal_ear_pigmentation0.75211712
99MP0009046_muscle_twitch0.75010987
100MP0002160_abnormal_reproductive_system0.74900273

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)7.22648346
2Unilateral renal agenesis (HP:0000122)3.70722897
3Failure to thrive in infancy (HP:0001531)3.62786976
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.43751033
5Absent/shortened dynein arms (HP:0200106)3.43751033
6Hip dysplasia (HP:0001385)3.28705258
7Abnormality of the labia minora (HP:0012880)3.27361750
8Tubulointerstitial nephritis (HP:0001970)3.16948535
9Neonatal respiratory distress (HP:0002643)3.15214387
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.04912737
11Nephronophthisis (HP:0000090)2.98369460
12Nephrogenic diabetes insipidus (HP:0009806)2.96320497
13Absent speech (HP:0001344)2.93285986
14Goiter (HP:0000853)2.88088049
15Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.83960938
16Occipital encephalocele (HP:0002085)2.73559268
17Abnormal respiratory epithelium morphology (HP:0012253)2.71837890
18Abnormal respiratory motile cilium morphology (HP:0005938)2.71837890
19Infertility (HP:0000789)2.71054930
20Abnormality of the renal medulla (HP:0100957)2.70452435
21Abnormality of the fovea (HP:0000493)2.69633034
22Enlarged epiphyses (HP:0010580)2.64203002
23Abnormal ciliary motility (HP:0012262)2.62153815
24Optic nerve hypoplasia (HP:0000609)2.52694941
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.52242349
26Hypoplasia of the fovea (HP:0007750)2.52242349
27Hypoplastic ischia (HP:0003175)2.47806445
28Tetany (HP:0001281)2.44204785
29Polyuria (HP:0000103)2.42034634
30Hypothermia (HP:0002045)2.37319787
31Abnormal urine output (HP:0012590)2.36299182
32Male infertility (HP:0003251)2.33622904
33Lissencephaly (HP:0001339)2.30059349
34Gait imbalance (HP:0002141)2.28513898
35Abnormality of the pubic bones (HP:0003172)2.27424141
36Medial flaring of the eyebrow (HP:0010747)2.27408529
37Severe Myopia (HP:0011003)2.26170499
38Truncal obesity (HP:0001956)2.25222136
39Attenuation of retinal blood vessels (HP:0007843)2.24850784
40Abnormal respiratory motile cilium physiology (HP:0012261)2.23845438
41Polydipsia (HP:0001959)2.23474617
42Abnormal drinking behavior (HP:0030082)2.23474617
43Hypokalemic alkalosis (HP:0001949)2.22181134
44Agitation (HP:0000713)2.21935730
45Hyperglycinemia (HP:0002154)2.18880206
46Abnormality of renal excretion (HP:0011036)2.14565962
47Congenital primary aphakia (HP:0007707)2.14527536
48Amyotrophic lateral sclerosis (HP:0007354)2.14204553
49Bony spicule pigmentary retinopathy (HP:0007737)2.12894423
50Abnormality of chloride homeostasis (HP:0011422)2.11643336
51Hyperaldosteronism (HP:0000859)2.11123241
52Polyphagia (HP:0002591)2.10999252
53Increased circulating renin level (HP:0000848)2.10888419
54Abnormality of the ischium (HP:0003174)2.10464261
55Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.10181453
56Retinal dysplasia (HP:0007973)2.10092145
57Metabolic alkalosis (HP:0200114)2.10015141
58Hypomagnesemia (HP:0002917)2.08836453
59Hyperventilation (HP:0002883)2.08321365
60Hyperpituitarism (HP:0010514)2.06199531
61Stage 5 chronic kidney disease (HP:0003774)2.05327643
62Volvulus (HP:0002580)2.02535582
63Hyperactive renin-angiotensin system (HP:0000841)2.00809910
64Genetic anticipation (HP:0003743)1.99779752
65Chorioretinal atrophy (HP:0000533)1.99560917
66Partial agenesis of the corpus callosum (HP:0001338)1.98692603
67Vaginal atresia (HP:0000148)1.98302634
68Tented upper lip vermilion (HP:0010804)1.97630076
69Hypsarrhythmia (HP:0002521)1.97502737
70Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97399443
71Hypoplasia of the brainstem (HP:0002365)1.97399443
72Abnormality of renin-angiotensin system (HP:0000847)1.97248333
73Progressive cerebellar ataxia (HP:0002073)1.96650193
74Chronic hepatic failure (HP:0100626)1.96388014
75Focal motor seizures (HP:0011153)1.95784765
76Congenital sensorineural hearing impairment (HP:0008527)1.94801102
77Intestinal atresia (HP:0011100)1.93226501
78Conjugated hyperbilirubinemia (HP:0002908)1.92601839
79Peripheral hypomyelination (HP:0007182)1.92361534
80Esotropia (HP:0000565)1.92335893
81Genital tract atresia (HP:0001827)1.89161194
82Tubulointerstitial abnormality (HP:0001969)1.87938370
83Epidermoid cyst (HP:0200040)1.86748966
84Horizontal nystagmus (HP:0000666)1.84675144
85Hypokalemia (HP:0002900)1.83869996
86Decreased circulating renin level (HP:0003351)1.81552305
87Methylmalonic acidemia (HP:0002912)1.81279167
88EEG with generalized epileptiform discharges (HP:0011198)1.81238850
89Pendular nystagmus (HP:0012043)1.81108447
90Intellectual disability, moderate (HP:0002342)1.80502186
91Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.77968092
92Sclerocornea (HP:0000647)1.76132492
93Abnormality of lateral ventricle (HP:0030047)1.76019983
94Impulsivity (HP:0100710)1.73802510
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.73028727
96Poor coordination (HP:0002370)1.71853667
97Scrotal hypoplasia (HP:0000046)1.71468519
98Tubular atrophy (HP:0000092)1.71155470
99Epileptiform EEG discharges (HP:0011182)1.68880083
100Shoulder girdle muscle weakness (HP:0003547)1.68476477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.88660846
2EPHA43.82080267
3CASK3.64439401
4MAP3K43.49973900
5PNCK3.32424675
6MST1R3.17737938
7MET2.63044897
8MAP2K72.55985270
9BCR2.30947319
10STK38L2.15170165
11WNK32.11358522
12MAP4K22.08811927
13MARK12.07422100
14INSRR2.07406706
15MAP3K62.07081420
16OXSR12.05944745
17PTK2B1.98676156
18PLK21.89672447
19ERBB31.79589216
20DDR21.77872074
21PLK41.75904632
22CAMK1G1.75552636
23DAPK21.71018017
24EPHA31.70697311
25MAP2K41.58166073
26BMX1.54747888
27DYRK1B1.52007302
28TESK11.50922088
29MAPK131.42802320
30STK391.36067579
31AKT31.35881905
32SIK21.35835481
33WNK41.33737893
34CSF1R1.32491823
35FGR1.30880180
36BRD41.28515162
37RET1.11593900
38STK381.05615984
39FRK1.02060935
40DYRK20.98119247
41BCKDK0.96769081
42RPS6KA40.95772550
43SRPK10.83742876
44NEK60.77834964
45MAP3K50.74811824
46MAPK150.73480017
47FER0.72849752
48ERBB20.72051822
49CSNK1G30.71299667
50UHMK10.69120410
51MINK10.68560496
52CSNK1G20.67141585
53ICK0.65566464
54GRK70.64203499
55CSNK1A1L0.63739450
56PRKCE0.62471123
57PKN10.59091768
58PRKCZ0.58972602
59DYRK30.58246829
60ADRBK20.56886073
61TAOK30.53554100
62PRKCG0.53480928
63CDK50.51950447
64PDGFRB0.51903106
65LMTK20.50747096
66NTRK20.48855824
67CAMK10.47963739
68MAP3K70.47565022
69CSNK1G10.46091730
70GRK10.45038384
71CDK60.44328751
72JAK20.43693078
73GRK50.43308427
74DYRK1A0.41680070
75BLK0.41301452
76PINK10.40570832
77CAMK40.39659167
78NME10.39639156
79CDK70.39598569
80RPS6KA20.37205090
81CAMK2A0.35260077
82PASK0.35165045
83MAP2K20.32613090
84IGF1R0.30823035
85EGFR0.30001394
86PRKAA10.29801097
87ZAK0.27738544
88PRKACA0.27630972
89ROCK10.27613477
90CDK30.26682366
91PAK30.26311801
92EPHA20.25681184
93STK240.25625252
94MAPK90.25030478
95SGK20.24512985
96MAP2K60.24496951
97RPS6KA50.24391418
98MARK20.24222102
99BUB10.24189040
100SIK30.22568715

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.47078792
2Nicotine addiction_Homo sapiens_hsa050334.46898951
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.81425010
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56661623
5Butanoate metabolism_Homo sapiens_hsa006502.56592959
6GABAergic synapse_Homo sapiens_hsa047272.38542241
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26566257
8Linoleic acid metabolism_Homo sapiens_hsa005911.95796022
9Morphine addiction_Homo sapiens_hsa050321.94540504
10Taste transduction_Homo sapiens_hsa047421.88558916
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.83158192
12Synaptic vesicle cycle_Homo sapiens_hsa047211.81208667
13Fanconi anemia pathway_Homo sapiens_hsa034601.79614077
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78506143
15Fatty acid biosynthesis_Homo sapiens_hsa000611.60468012
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59889863
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51755276
18Tryptophan metabolism_Homo sapiens_hsa003801.49359831
19Glutamatergic synapse_Homo sapiens_hsa047241.44078025
20Fat digestion and absorption_Homo sapiens_hsa049751.39155704
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35724420
22Circadian entrainment_Homo sapiens_hsa047131.32083002
23Selenocompound metabolism_Homo sapiens_hsa004501.31741997
24Ether lipid metabolism_Homo sapiens_hsa005651.31448394
25Salivary secretion_Homo sapiens_hsa049701.27532111
26ABC transporters_Homo sapiens_hsa020101.25405203
27Type II diabetes mellitus_Homo sapiens_hsa049301.23456393
28Renin-angiotensin system_Homo sapiens_hsa046141.20746838
29Thyroid hormone synthesis_Homo sapiens_hsa049181.18961758
30Olfactory transduction_Homo sapiens_hsa047401.17286597
31Serotonergic synapse_Homo sapiens_hsa047261.09484192
32Glycerolipid metabolism_Homo sapiens_hsa005611.09279324
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08242213
34Ovarian steroidogenesis_Homo sapiens_hsa049131.06265019
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.06182125
36Vitamin digestion and absorption_Homo sapiens_hsa049770.97050264
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96386304
38Bile secretion_Homo sapiens_hsa049760.96384056
39Retinol metabolism_Homo sapiens_hsa008300.95377457
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95287133
41Oocyte meiosis_Homo sapiens_hsa041140.90737617
42Insulin secretion_Homo sapiens_hsa049110.87740118
43Basal transcription factors_Homo sapiens_hsa030220.85366385
44Phenylalanine metabolism_Homo sapiens_hsa003600.77519453
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76727645
46Dopaminergic synapse_Homo sapiens_hsa047280.75829503
47Axon guidance_Homo sapiens_hsa043600.75391898
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74083519
49Arachidonic acid metabolism_Homo sapiens_hsa005900.73640883
50Collecting duct acid secretion_Homo sapiens_hsa049660.73428923
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72753820
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.72591144
53RNA degradation_Homo sapiens_hsa030180.71880352
54Arginine and proline metabolism_Homo sapiens_hsa003300.69984284
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67551205
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66320400
57Cholinergic synapse_Homo sapiens_hsa047250.65234313
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64539402
59Vibrio cholerae infection_Homo sapiens_hsa051100.63728408
60Sphingolipid metabolism_Homo sapiens_hsa006000.63592287
61Phototransduction_Homo sapiens_hsa047440.63568857
62Gastric acid secretion_Homo sapiens_hsa049710.63454142
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61987495
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59920188
65Protein digestion and absorption_Homo sapiens_hsa049740.59603001
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58548540
67beta-Alanine metabolism_Homo sapiens_hsa004100.58130782
68Long-term depression_Homo sapiens_hsa047300.57938990
69Autoimmune thyroid disease_Homo sapiens_hsa053200.57695322
70cAMP signaling pathway_Homo sapiens_hsa040240.57686867
71Regulation of autophagy_Homo sapiens_hsa041400.57195290
72Calcium signaling pathway_Homo sapiens_hsa040200.57006507
73Gap junction_Homo sapiens_hsa045400.54866792
74Alcoholism_Homo sapiens_hsa050340.53707496
75Fatty acid metabolism_Homo sapiens_hsa012120.52570789
76Histidine metabolism_Homo sapiens_hsa003400.52011332
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51833543
78Choline metabolism in cancer_Homo sapiens_hsa052310.49887481
79Caffeine metabolism_Homo sapiens_hsa002320.46980838
80Cocaine addiction_Homo sapiens_hsa050300.45629004
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45225077
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.45100615
83Tight junction_Homo sapiens_hsa045300.44338984
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43699088
85Inositol phosphate metabolism_Homo sapiens_hsa005620.42463102
86Dorso-ventral axis formation_Homo sapiens_hsa043200.41791631
87Pancreatic secretion_Homo sapiens_hsa049720.41682520
88Chemical carcinogenesis_Homo sapiens_hsa052040.39931063
89Starch and sucrose metabolism_Homo sapiens_hsa005000.39907520
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39569394
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39202777
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36559574
93Propanoate metabolism_Homo sapiens_hsa006400.35849525
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34819687
95Peroxisome_Homo sapiens_hsa041460.34279795
96Homologous recombination_Homo sapiens_hsa034400.33904648
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33435380
98Dilated cardiomyopathy_Homo sapiens_hsa054140.33393892
99Lysine degradation_Homo sapiens_hsa003100.31710018
100Fatty acid degradation_Homo sapiens_hsa000710.31100917

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