ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene biosynthetic process (GO:0019370)	9.03557453
2	glutathione biosynthetic process (GO:0006750)	7.19512432
3	peptide catabolic process (GO:0043171)	7.07706078
4	cysteine metabolic process (GO:0006534)	7.02540825
5	cobalamin metabolic process (GO:0009235)	6.91385416
6	nonribosomal peptide biosynthetic process (GO:0019184)	6.58014443
7	leukotriene metabolic process (GO:0006691)	6.14650996
8	icosanoid biosynthetic process (GO:0046456)	5.78643892
9	fatty acid derivative biosynthetic process (GO:1901570)	5.78643892
10	serine family amino acid biosynthetic process (GO:0009070)	5.11273080
11	rRNA methylation (GO:0031167)	4.83687090
12	unsaturated fatty acid biosynthetic process (GO:0006636)	4.68974480
13	peptide biosynthetic process (GO:0043043)	4.64732034
14	glutathione metabolic process (GO:0006749)	4.51695189
15	urate metabolic process (GO:0046415)	4.45336940
16	rRNA modification (GO:0000154)	4.30501922
17	regulation of hippo signaling (GO:0035330)	4.00671668
18	regulation of response to osmotic stress (GO:0047484)	3.82758402
19	NIK/NF-kappaB signaling (GO:0038061)	3.76598709
20	digestion (GO:0007586)	3.74919973
21	cellular modified amino acid catabolic process (GO:0042219)	3.74646549
22	mitochondrial calcium ion transport (GO:0006851)	3.64955306
23	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.61841585
24	type B pancreatic cell proliferation (GO:0044342)	3.60912944
25	polyketide metabolic process (GO:0030638)	3.59485536
26	doxorubicin metabolic process (GO:0044598)	3.59485536
27	daunorubicin metabolic process (GO:0044597)	3.59485536
28	tRNA methylation (GO:0030488)	3.52785082
29	DNA topological change (GO:0006265)	3.40443853
30	icosanoid metabolic process (GO:0006690)	3.33118692
31	fatty acid derivative metabolic process (GO:1901568)	3.33118692
32	long term synaptic depression (GO:0060292)	3.29211095
33	drug transmembrane transport (GO:0006855)	3.27561436
34	aminoglycoside antibiotic metabolic process (GO:0030647)	3.22761777
35	ncRNA 3-end processing (GO:0043628)	3.18586372
36	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	3.13850646
37	unsaturated fatty acid metabolic process (GO:0033559)	3.12150599
38	activation of NF-kappaB-inducing kinase activity (GO:0007250)	3.08115858
39	ribosome biogenesis (GO:0042254)	3.07976805
40	cellular modified amino acid biosynthetic process (GO:0042398)	3.01030568
41	natural killer cell activation involved in immune response (GO:0002323)	2.98457366
42	sulfur amino acid biosynthetic process (GO:0000097)	2.91258756
43	chromosome condensation (GO:0030261)	2.90770765
44	glutathione derivative metabolic process (GO:1901685)	2.86011311
45	glutathione derivative biosynthetic process (GO:1901687)	2.86011311
46	transcription from mitochondrial promoter (GO:0006390)	2.80501768
47	ribosome assembly (GO:0042255)	2.78686164
48	positive regulation of T cell differentiation in thymus (GO:0033089)	2.77256721
49	cellular zinc ion homeostasis (GO:0006882)	2.76032631
50	auditory receptor cell differentiation (GO:0042491)	2.71822822
51	DNA packaging (GO:0006323)	2.66319244
52	mitochondrion distribution (GO:0048311)	2.66256628
53	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.65407320
54	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.65326985
55	adaptation of signaling pathway (GO:0023058)	2.64730034
56	drug transport (GO:0015893)	2.64532760
57	sperm motility (GO:0030317)	2.63547501
58	lung secretory cell differentiation (GO:0061140)	2.60729786
59	fusion of sperm to egg plasma membrane (GO:0007342)	2.54139491
60	artery smooth muscle contraction (GO:0014824)	2.53167875
61	pentose metabolic process (GO:0019321)	2.51557648
62	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.49541335
63	deoxyribose phosphate biosynthetic process (GO:0046385)	2.49541335
64	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.45696236
65	galactose catabolic process (GO:0019388)	2.45695818
66	regulation of immunoglobulin secretion (GO:0051023)	2.44656100
67	lymph node development (GO:0048535)	2.44209810
68	regulation of chronic inflammatory response (GO:0002676)	2.42510251
69	DNA methylation involved in gamete generation (GO:0043046)	2.41919239
70	regulation of vitamin metabolic process (GO:0030656)	2.41390598
71	prostanoid biosynthetic process (GO:0046457)	2.40218674
72	prostaglandin biosynthetic process (GO:0001516)	2.40218674
73	RNA methylation (GO:0001510)	2.39275242
74	pseudouridine synthesis (GO:0001522)	2.38914885
75	tetrapyrrole metabolic process (GO:0033013)	2.38736660
76	binding of sperm to zona pellucida (GO:0007339)	2.38720967
77	mitochondrial fusion (GO:0008053)	2.37681560
78	sperm-egg recognition (GO:0035036)	2.36889149
79	pyrimidine-containing compound salvage (GO:0008655)	2.35892363
80	pyrimidine nucleoside salvage (GO:0043097)	2.35892363
81	monosaccharide catabolic process (GO:0046365)	2.35513747
82	glutamate metabolic process (GO:0006536)	2.33266515
83	interleukin-6-mediated signaling pathway (GO:0070102)	2.33018255
84	tRNA modification (GO:0006400)	2.31659680
85	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.30101422
86	positive regulation of NIK/NF-kappaB signaling (GO:1901224)	2.29030161
87	energy homeostasis (GO:0097009)	2.27688691
88	membrane protein ectodomain proteolysis (GO:0006509)	2.27132220
89	regulation of proton transport (GO:0010155)	2.27099361
90	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.26776870
91	protein maturation by protein folding (GO:0022417)	2.26569029
92	hepatocyte differentiation (GO:0070365)	2.23441298
93	centriole assembly (GO:0098534)	2.22741961
94	mature B cell differentiation involved in immune response (GO:0002313)	2.20832343
95	peptidyl-threonine dephosphorylation (GO:0035970)	2.20813357
96	negative regulation of bone resorption (GO:0045779)	2.20642255
97	deoxyribonucleotide biosynthetic process (GO:0009263)	2.20357667
98	nucleoside diphosphate biosynthetic process (GO:0009133)	2.19863217
99	leukocyte tethering or rolling (GO:0050901)	2.19818205
100	centriole replication (GO:0007099)	2.18427756

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.06031238
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.02917094
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.82101430
4	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.80200196
5	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.76043982
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.43179142
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32952848
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.12613932
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.11425107
10	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.99817044
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.95285255
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.92006529
13	MYC_22102868_ChIP-Seq_BL_Human	1.91703902
14	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.87578541
15	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74653876
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.73359935
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.62872969
18	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62230113
19	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.61450047
20	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.59146788
21	BCOR_27268052_Chip-Seq_Bcells_Human	1.58846241
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.55777164
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53862752
24	P68_20966046_ChIP-Seq_HELA_Human	1.53182149
25	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.52378846
26	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.52253902
27	MYB_26560356_Chip-Seq_TH2_Human	1.48135955
28	LXR_22292898_ChIP-Seq_THP-1_Human	1.47565413
29	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.45233338
30	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.44609075
31	VDR_21846776_ChIP-Seq_THP-1_Human	1.37672136
32	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.37073224
33	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.36962618
34	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.35840037
35	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.34412812
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.33885404
37	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.33864003
38	BCL6_27268052_Chip-Seq_Bcells_Human	1.33539110
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.31247084
40	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.29297150
41	ZNF263_19887448_ChIP-Seq_K562_Human	1.29177582
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.27767693
43	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.26494766
44	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.25758587
45	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.25242193
46	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.24210509
47	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.23217812
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.23193977
49	GATA6_25053715_ChIP-Seq_YYC3_Human	1.22460056
50	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.22373773
51	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.22289751
52	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21684930
53	PHF8_20622854_ChIP-Seq_HELA_Human	1.16462059
54	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.16452029
55	ATF3_27146783_Chip-Seq_COLON_Human	1.15723304
56	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.15504636
57	E2F1_20622854_ChIP-Seq_HELA_Human	1.13760285
58	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.13367802
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.11334968
60	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.10971559
61	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.08638759
62	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	1.07907561
63	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.07478293
64	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.06196230
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06031303
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05751481
67	MAF_26560356_Chip-Seq_TH2_Human	1.05050157
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.04714662
69	P300_27268052_Chip-Seq_Bcells_Human	1.04133445
70	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03972151
71	VDR_24763502_ChIP-Seq_THP-1_Human	1.03910265
72	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.03492286
73	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.02172171
74	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.02014511
75	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.99669747
76	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.99610064
77	NCOR1_26117541_ChIP-Seq_K562_Human	0.98656027
78	SMC4_20622854_ChIP-Seq_HELA_Human	0.98234665
79	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97480194
80	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.97177452
81	UTX_26944678_Chip-Seq_JUKART_Human	0.97136499
82	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.96424839
83	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.95966715
84	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95942853
85	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95222750
86	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.94293326
87	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93826139
88	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.93669741
89	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.93511198
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.93161044
91	STAT1_20625510_ChIP-Seq_HELA_Human	0.92252345
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91173049
93	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.91100928
94	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.90861885
95	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.90845024
96	RACK7_27058665_Chip-Seq_MCF-7_Human	0.90675303
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90164312
98	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90023937
99	MAF_26560356_Chip-Seq_TH1_Human	0.89675031
100	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.89297825

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	5.08661249
2	MP0001348_abnormal_lacrimal_gland	3.74972956
3	MP0003786_premature_aging	3.57593691
4	MP0002876_abnormal_thyroid_physiology	3.37577920
5	MP0002089_abnormal_postnatal_growth/wei	2.85593074
6	MP0005410_abnormal_fertilization	2.68263063
7	MP0002139_abnormal_hepatobiliary_system	2.59837714
8	MP0001873_stomach_inflammation	2.54094201
9	MP0002396_abnormal_hematopoietic_system	2.38049042
10	MP0001835_abnormal_antigen_presentation	2.14519572
11	MP0000613_abnormal_salivary_gland	2.12840128
12	MP0005379_endocrine/exocrine_gland_phen	2.11000362
13	MP0003011_delayed_dark_adaptation	2.09149684
14	MP0008961_abnormal_basal_metabolism	2.01297710
15	MP0009333_abnormal_splenocyte_physiolog	1.99321524
16	MP0002148_abnormal_hypersensitivity_rea	1.98455107
17	MP0002138_abnormal_hepatobiliary_system	1.94785991
18	MP0003656_abnormal_erythrocyte_physiolo	1.90953908
19	MP0000685_abnormal_immune_system	1.90057939
20	MP0002877_abnormal_melanocyte_morpholog	1.87734562
21	MP0005310_abnormal_salivary_gland	1.85948584
22	MP0002163_abnormal_gland_morphology	1.80148996
23	MP0006082_CNS_inflammation	1.68411122
24	MP0009785_altered_susceptibility_to	1.60541046
25	MP0004957_abnormal_blastocyst_morpholog	1.55440037
26	MP0003436_decreased_susceptibility_to	1.54502038
27	MP0005360_urolithiasis	1.51795292
28	MP0005670_abnormal_white_adipose	1.46596287
29	MP0008875_abnormal_xenobiotic_pharmacok	1.45085751
30	MP0000371_diluted_coat_color	1.39309827
31	MP0003806_abnormal_nucleotide_metabolis	1.37973739
32	MP0003111_abnormal_nucleus_morphology	1.36162601
33	MP0010155_abnormal_intestine_physiology	1.32888447
34	MP0001666_abnormal_nutrient_absorption	1.32466524
35	MP0008872_abnormal_physiological_respon	1.28914904
36	MP0005083_abnormal_biliary_tract	1.27870566
37	MP0000681_abnormal_thyroid_gland	1.24873350
38	MP0008007_abnormal_cellular_replicative	1.21541858
39	MP0008932_abnormal_embryonic_tissue	1.21479197
40	MP0000858_altered_metastatic_potential	1.14270814
41	MP0000716_abnormal_immune_system	1.14103263
42	MP0002452_abnormal_antigen_presenting	1.13547909
43	MP0002723_abnormal_immune_serum	1.13301968
44	MP0005451_abnormal_body_composition	1.13233497
45	MP0005085_abnormal_gallbladder_physiolo	1.13146439
46	MP0001929_abnormal_gametogenesis	1.13029781
47	MP0000733_abnormal_muscle_development	1.11483613
48	MP0005058_abnormal_lysosome_morphology	1.10293345
49	MP0008469_abnormal_protein_level	1.09912483
50	MP0003698_abnormal_male_reproductive	1.08640585
51	MP0000013_abnormal_adipose_tissue	1.07889396
52	MP0001661_extended_life_span	1.06248146
53	MP0002419_abnormal_innate_immunity	1.06223334
54	MP0001819_abnormal_immune_cell	1.05707075
55	MP0005332_abnormal_amino_acid	1.05508640
56	MP0002722_abnormal_immune_system	1.04916379
57	MP0005647_abnormal_sex_gland	1.04339038
58	MP0001845_abnormal_inflammatory_respons	1.03690334
59	MP0002420_abnormal_adaptive_immunity	1.03599403
60	MP0002398_abnormal_bone_marrow	1.02470132
61	MP0000689_abnormal_spleen_morphology	1.00872576
62	MP0001800_abnormal_humoral_immune	1.00340438
63	MP0000490_abnormal_crypts_of	0.97989873
64	MP0002429_abnormal_blood_cell	0.97842639
65	MP0002405_respiratory_system_inflammati	0.96537104
66	MP0009840_abnormal_foam_cell	0.95552067
67	MP0002166_altered_tumor_susceptibility	0.94890315
68	MP0000538_abnormal_urinary_bladder	0.94141776
69	MP0003077_abnormal_cell_cycle	0.93762796
70	MP0005025_abnormal_response_to	0.90986707
71	MP0005365_abnormal_bile_salt	0.88346329
72	MP0005000_abnormal_immune_tolerance	0.87835175
73	MP0009643_abnormal_urine_homeostasis	0.87093427
74	MP0005167_abnormal_blood-brain_barrier	0.87019285
75	MP0009697_abnormal_copulation	0.86559020
76	MP0008877_abnormal_DNA_methylation	0.85986617
77	MP0001501_abnormal_sleep_pattern	0.85302010
78	MP0004947_skin_inflammation	0.85026428
79	MP0005319_abnormal_enzyme/_coenzyme	0.83706721
80	MP0001533_abnormal_skeleton_physiology	0.83559216
81	MP0008789_abnormal_olfactory_epithelium	0.82146005
82	MP0000003_abnormal_adipose_tissue	0.80195397
83	MP0009765_abnormal_xenobiotic_induced	0.79699296
84	MP0001849_ear_inflammation	0.79593565
85	MP0003252_abnormal_bile_duct	0.78867823
86	MP0003693_abnormal_embryo_hatching	0.78739660
87	MP0001663_abnormal_digestive_system	0.78566922
88	MP0000703_abnormal_thymus_morphology	0.76959736
89	MP0003303_peritoneal_inflammation	0.76849450
90	MP0005164_abnormal_response_to	0.75954498
91	MP0001730_embryonic_growth_arrest	0.75760579
92	MP0001765_abnormal_ion_homeostasis	0.75677083
93	MP0005671_abnormal_response_to	0.73897755
94	MP0000609_abnormal_liver_physiology	0.73671135
95	MP0004808_abnormal_hematopoietic_stem	0.72894500
96	MP0002136_abnormal_kidney_physiology	0.72780666
97	MP0003091_abnormal_cell_migration	0.72445343
98	MP0004019_abnormal_vitamin_homeostasis	0.72273049
99	MP0003795_abnormal_bone_structure	0.71338982
100	MP0003950_abnormal_plasma_membrane	0.70511185

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Subcapsular cataract (HP:0000523)	4.10480961
2	Focal segmental glomerulosclerosis (HP:0000097)	3.74163831
3	Exocrine pancreatic insufficiency (HP:0001738)	3.70787668
4	Steatorrhea (HP:0002570)	3.69178100
5	Gout (HP:0001997)	3.64902056
6	Glomerulosclerosis (HP:0000096)	3.58043425
7	Median cleft lip (HP:0000161)	3.50412631
8	Neonatal respiratory distress (HP:0002643)	3.42886551
9	Carpal bone hypoplasia (HP:0001498)	3.38913762
10	Heterotopia (HP:0002282)	3.32416416
11	Abnormality of glycosaminoglycan metabolism (HP:0004371)	3.30862290
12	Abnormality of mucopolysaccharide metabolism (HP:0011020)	3.30862290
13	Abnormality of polysaccharide metabolism (HP:0011012)	3.30862290
14	Posterior subcapsular cataract (HP:0007787)	3.30129576
15	Urinary glycosaminoglycan excretion (HP:0003541)	3.27885563
16	Mucopolysacchariduria (HP:0008155)	3.27885563
17	Hand muscle atrophy (HP:0009130)	3.27189342
18	Cone-rod dystrophy (HP:0000548)	3.19470790
19	Thyroid-stimulating hormone excess (HP:0002925)	3.15211776
20	Increased purine levels (HP:0004368)	3.03684918
21	Hyperuricemia (HP:0002149)	3.03684918
22	Distal upper limb amyotrophy (HP:0007149)	2.99678122
23	Upper limb amyotrophy (HP:0009129)	2.99678122
24	Squamous cell carcinoma (HP:0002860)	2.99609996
25	Fat malabsorption (HP:0002630)	2.93480063
26	Tubulointerstitial nephritis (HP:0001970)	2.88434117
27	Glucose intolerance (HP:0000833)	2.85718474
28	Goiter (HP:0000853)	2.85280444
29	Flattened epiphyses (HP:0003071)	2.75502046
30	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.74107021
31	Hypoproteinemia (HP:0003075)	2.69572524
32	Cholecystitis (HP:0001082)	2.66494593
33	Abnormal gallbladder physiology (HP:0012438)	2.66494593
34	Dysostosis multiplex (HP:0000943)	2.57650766
35	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.54797842
36	Rough bone trabeculation (HP:0100670)	2.49517460
37	Hydroxyprolinuria (HP:0003080)	2.49041291
38	Abnormality of proline metabolism (HP:0010907)	2.49041291
39	J-shaped sella turcica (HP:0002680)	2.46592945
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.46138275
41	Abnormality of alanine metabolism (HP:0010916)	2.46138275
42	Hyperalaninemia (HP:0003348)	2.46138275
43	Malnutrition (HP:0004395)	2.39249715
44	Flat acetabular roof (HP:0003180)	2.32328770
45	Short femoral neck (HP:0100864)	2.29168722
46	Severe combined immunodeficiency (HP:0004430)	2.26443792
47	Broad alveolar ridges (HP:0000187)	2.24386277
48	Polar cataract (HP:0010696)	2.23470482
49	Severe visual impairment (HP:0001141)	2.23036825
50	Retinal dysplasia (HP:0007973)	2.20510974
51	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.19577881
52	Prolonged neonatal jaundice (HP:0006579)	2.18606404
53	Aplasia/hypoplasia of the femur (HP:0005613)	2.16748717
54	Increased serum ferritin (HP:0003281)	2.13546856
55	Abnormality of purine metabolism (HP:0004352)	2.13375771
56	Flared metaphyses (HP:0003015)	2.12176775
57	Distal lower limb muscle weakness (HP:0009053)	2.05622959
58	Mesangial abnormality (HP:0001966)	2.05586152
59	Nuclear cataract (HP:0100018)	2.04813881
60	Renal cortical cysts (HP:0000803)	2.04393569
61	Broad face (HP:0000283)	2.03265618
62	Microretrognathia (HP:0000308)	2.02702210
63	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.00619009
64	Combined immunodeficiency (HP:0005387)	1.99142905
65	Irregular vertebral endplates (HP:0003301)	1.97562948
66	Tetraplegia (HP:0002445)	1.96389940
67	Cutaneous melanoma (HP:0012056)	1.95344791
68	Stage 5 chronic kidney disease (HP:0003774)	1.95343115
69	Type II lissencephaly (HP:0007260)	1.94219183
70	Rhabdomyolysis (HP:0003201)	1.94020419
71	Stridor (HP:0010307)	1.92937445
72	Facial hemangioma (HP:0000329)	1.91905179
73	Abnormality of lateral ventricle (HP:0030047)	1.88370541
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87457007
75	Abnormal trabecular bone morphology (HP:0100671)	1.86320049
76	Pancreatitis (HP:0001733)	1.85940443
77	IgG deficiency (HP:0004315)	1.84927631
78	Milia (HP:0001056)	1.84335073
79	Pustule (HP:0200039)	1.84058593
80	Broad palm (HP:0001169)	1.82835572
81	Abnormality of the odontoid process (HP:0003310)	1.80866728
82	Cerebellar dysplasia (HP:0007033)	1.78362335
83	Unilateral renal agenesis (HP:0000122)	1.77580856
84	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.76986865
85	Abnormality of glycolysis (HP:0004366)	1.74120164
86	Abnormality of fatty-acid metabolism (HP:0004359)	1.73704466
87	Abnormal glucose tolerance (HP:0001952)	1.73516242
88	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.72884552
89	Femoral bowing (HP:0002980)	1.71457669
90	Hypoplasia of the odontoid process (HP:0003311)	1.70667268
91	Vacuolated lymphocytes (HP:0001922)	1.69713300
92	Conical tooth (HP:0000698)	1.69366311
93	Abnormality of the vertebral endplates (HP:0005106)	1.67253320
94	Abnormality of nucleobase metabolism (HP:0010932)	1.67174480
95	Dyschromatopsia (HP:0007641)	1.66425075
96	Small epiphyses (HP:0010585)	1.66006611
97	Abnormality of liposaccharide metabolism (HP:0010968)	1.65497520
98	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.65497520
99	Abnormality of glycolipid metabolism (HP:0010969)	1.65497520
100	Constricted visual fields (HP:0001133)	1.64782920

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	5.31167668
2	MET	5.19856312
3	ERN1	4.71445855
4	FLT3	2.76039350
5	IRAK3	2.29843918
6	STK24	2.10225546
7	IKBKB	2.00855078
8	MAP3K14	2.00411643
9	STK16	1.98049914
10	TGFBR2	1.97538398
11	TBK1	1.95978514
12	TTN	1.95709566
13	MAP2K2	1.94080150
14	NME2	1.84859990
15	EPHA2	1.84629214
16	RPS6KA4	1.71093219
17	IKBKE	1.64071943
18	STK38	1.56413014
19	IRAK4	1.56207434
20	EIF2AK3	1.55791384
21	VRK2	1.51571166
22	GRK7	1.50626421
23	EIF2AK2	1.48084480
24	PIM2	1.47592207
25	CSF1R	1.44096446
26	PLK4	1.39618899
27	STK10	1.39304980
28	STK38L	1.35647666
29	GRK6	1.32353541
30	MOS	1.29001236
31	PDK2	1.23940144
32	CDK8	1.23290124
33	CDK12	1.17704109
34	PRPF4B	1.17702947
35	BMPR1B	1.14543253
36	TESK1	1.13980329
37	TYK2	1.13174554
38	SRPK1	1.10238214
39	SIK1	1.10035288
40	RPS6KL1	1.02967238
41	RPS6KC1	1.02967238
42	MAP4K1	0.99450406
43	TESK2	0.96683419
44	LMTK2	0.94657596
45	BUB1	0.91445772
46	MAP3K6	0.90926420
47	STK4	0.87081835
48	TLK1	0.86893628
49	BCKDK	0.86164833
50	RPS6KA6	0.84845526
51	RPS6KA2	0.84058475
52	CHUK	0.82719263
53	MAPK7	0.82696954
54	TRPM7	0.81028728
55	BMX	0.76784177
56	IRAK1	0.74887188
57	BRD4	0.72431195
58	PIK3CG	0.70109090
59	MAP3K8	0.68417838
60	CDK7	0.65982699
61	IRAK2	0.65440612
62	NEK6	0.65155698
63	PTK2	0.64996947
64	DAPK1	0.64880977
65	MAP3K11	0.63613223
66	TAOK2	0.63464759
67	ZAP70	0.61956718
68	MAP3K13	0.60057933
69	CDK4	0.59581175
70	CDK9	0.56855559
71	NUAK1	0.55848501
72	PRKCD	0.54652229
73	INSRR	0.53046757
74	RPS6KB2	0.52556733
75	PKN2	0.50027157
76	IGF1R	0.49213195
77	MAPK11	0.47134771
78	MAPKAPK2	0.46543731
79	GRK5	0.45066252
80	MAP2K6	0.43183328
81	PBK	0.41910846
82	PDK1	0.40437165
83	AKT2	0.40353236
84	PIM1	0.39983839
85	MAP3K7	0.39852729
86	MATK	0.37023851
87	JAK1	0.35197440
88	AURKA	0.31744107
89	SIK3	0.29919588
90	ILK	0.29649521
91	RPS6KA1	0.29212328
92	AURKB	0.29009582
93	PLK2	0.28758673
94	ABL2	0.28501731
95	SCYL2	0.28148260
96	MAP3K1	0.27416607
97	CAMK2G	0.26795394
98	NEK2	0.26647908
99	KIT	0.26439993
100	PRKD3	0.24708869

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	9.11477293
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.10520561
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.62357601
4	Renin-angiotensin system_Homo sapiens_hsa04614	2.04815689
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.02104551
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.99412007
7	Galactose metabolism_Homo sapiens_hsa00052	1.88800866
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.80830603
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.72860098
10	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.60406635
11	Fat digestion and absorption_Homo sapiens_hsa04975	1.52596334
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.52232374
13	Pentose phosphate pathway_Homo sapiens_hsa00030	1.51674612
14	Homologous recombination_Homo sapiens_hsa03440	1.50216697
15	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.49852131
16	Caffeine metabolism_Homo sapiens_hsa00232	1.48383036
17	Glutathione metabolism_Homo sapiens_hsa00480	1.48239700
18	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.43959556
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.39117254
20	Herpes simplex infection_Homo sapiens_hsa05168	1.37432306
21	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.32354323
22	Sulfur relay system_Homo sapiens_hsa04122	1.30676979
23	Base excision repair_Homo sapiens_hsa03410	1.30211499
24	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.26155043
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25858919
26	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24362543
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24076274
28	Other glycan degradation_Homo sapiens_hsa00511	1.18878690
29	Protein digestion and absorption_Homo sapiens_hsa04974	1.13989459
30	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13763479
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.12130917
32	Influenza A_Homo sapiens_hsa05164	1.11167157
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.11105546
34	Proteasome_Homo sapiens_hsa03050	1.09607332
35	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.06856552
36	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.05789038
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04892661
38	Lysosome_Homo sapiens_hsa04142	1.00640426
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.99047843
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96567703
41	RNA transport_Homo sapiens_hsa03013	0.92591011
42	Carbon metabolism_Homo sapiens_hsa01200	0.91124167
43	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.90981750
44	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90590402
45	Legionellosis_Homo sapiens_hsa05134	0.85540081
46	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.84890795
47	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.80403740
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80385763
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76687186
50	Primary immunodeficiency_Homo sapiens_hsa05340	0.76612466
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.74751026
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73876833
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72642292
54	Fatty acid elongation_Homo sapiens_hsa00062	0.70004095
55	Sulfur metabolism_Homo sapiens_hsa00920	0.69964920
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.68896996
57	Pancreatic secretion_Homo sapiens_hsa04972	0.68338668
58	Spliceosome_Homo sapiens_hsa03040	0.68307113
59	One carbon pool by folate_Homo sapiens_hsa00670	0.64656339
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64615209
61	DNA replication_Homo sapiens_hsa03030	0.64248814
62	Hepatitis C_Homo sapiens_hsa05160	0.63320183
63	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62985316
64	TNF signaling pathway_Homo sapiens_hsa04668	0.61373296
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59574926
66	Basal transcription factors_Homo sapiens_hsa03022	0.59001293
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.58441104
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58295815
69	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.57560404
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57328048
71	Retinol metabolism_Homo sapiens_hsa00830	0.56617894
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56587960
73	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54670180
74	Acute myeloid leukemia_Homo sapiens_hsa05221	0.54548217
75	Leishmaniasis_Homo sapiens_hsa05140	0.52781711
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52477690
77	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.51641016
78	Bladder cancer_Homo sapiens_hsa05219	0.48887824
79	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48490064
80	Measles_Homo sapiens_hsa05162	0.48391538
81	Metabolic pathways_Homo sapiens_hsa01100	0.44563722
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43271875
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42883292
84	African trypanosomiasis_Homo sapiens_hsa05143	0.42342820
85	Fanconi anemia pathway_Homo sapiens_hsa03460	0.40619345
86	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39374851
87	Hepatitis B_Homo sapiens_hsa05161	0.38283013
88	Purine metabolism_Homo sapiens_hsa00230	0.37765586
89	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.37326393
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37111939
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.35731432
92	p53 signaling pathway_Homo sapiens_hsa04115	0.34753316
93	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.32777619
94	Apoptosis_Homo sapiens_hsa04210	0.32517677
95	Allograft rejection_Homo sapiens_hsa05330	0.24527867
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.24439657
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.23841638
98	Antigen processing and presentation_Homo sapiens_hsa04612	0.22043936
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.21737117
100	Notch signaling pathway_Homo sapiens_hsa04330	0.21676652

GGT4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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