GGT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion import (GO:0090280)5.47413162
2glomerular basement membrane development (GO:0032836)4.61359975
3glomerulus development (GO:0032835)4.44512371
4regulation of gonadotropin secretion (GO:0032276)4.43266345
5cell differentiation involved in metanephros development (GO:0072202)4.42462226
6positive regulation of digestive system process (GO:0060456)4.30886466
7parturition (GO:0007567)4.25230579
8phenylpropanoid metabolic process (GO:0009698)4.23524962
9glomerular visceral epithelial cell development (GO:0072015)4.09581587
10positive regulation of steroid hormone secretion (GO:2000833)4.00885827
11positive regulation of catecholamine secretion (GO:0033605)3.96916860
12glucocorticoid biosynthetic process (GO:0006704)3.70087507
13regulation of cellular extravasation (GO:0002691)3.68093832
14germ cell migration (GO:0008354)3.65508720
15glomerular epithelial cell development (GO:0072310)3.55874396
16adhesion of symbiont to host cell (GO:0044650)3.51836501
17virion attachment to host cell (GO:0019062)3.51836501
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51669805
19positive regulation of respiratory burst (GO:0060267)3.45429424
20endothelium development (GO:0003158)3.44797297
21antigen processing and presentation of endogenous antigen (GO:0019883)3.42218804
22blood vessel maturation (GO:0001955)3.37438986
23complement activation, alternative pathway (GO:0006957)3.36714978
24response to interferon-beta (GO:0035456)3.35997995
25platelet dense granule organization (GO:0060155)3.30451960
26mesenchymal cell differentiation involved in renal system development (GO:2001012)3.29982387
27mesenchymal cell differentiation involved in kidney development (GO:0072161)3.29982387
28tooth mineralization (GO:0034505)3.28262820
29positive regulation of natural killer cell differentiation (GO:0032825)3.27410090
30negative regulation of leukocyte migration (GO:0002686)3.25724057
31angiogenesis involved in wound healing (GO:0060055)3.24369808
32leukocyte migration involved in inflammatory response (GO:0002523)3.21748444
33positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18561984
34regulation of axon extension involved in axon guidance (GO:0048841)3.16620413
35positive regulation of monocyte chemotaxis (GO:0090026)3.08820749
36regulation of sequestering of triglyceride (GO:0010889)3.04382765
37opsonization (GO:0008228)3.04082757
38indole-containing compound catabolic process (GO:0042436)3.03363520
39indolalkylamine catabolic process (GO:0046218)3.03363520
40tryptophan catabolic process (GO:0006569)3.03363520
41regulation of corticosteroid hormone secretion (GO:2000846)3.02551363
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.01569567
43regulation of calcium ion import (GO:0090279)2.98108945
44toxin metabolic process (GO:0009404)2.97914019
45positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.96888860
46regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94251080
47kidney mesenchyme development (GO:0072074)2.94073999
48lymph vessel development (GO:0001945)2.90482447
49oxygen transport (GO:0015671)2.89398025
50cell migration involved in heart development (GO:0060973)2.89296854
51lymphoid progenitor cell differentiation (GO:0002320)2.88568881
52positive regulation of antigen processing and presentation (GO:0002579)2.87283393
53positive regulation of T-helper 1 type immune response (GO:0002827)2.86984405
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86403371
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86403371
56behavioral response to nicotine (GO:0035095)2.85841766
57metanephric mesenchyme development (GO:0072075)2.84324049
58response to type I interferon (GO:0034340)2.84069085
59protein heterotrimerization (GO:0070208)2.83660984
60positive regulation of interleukin-17 production (GO:0032740)2.83359585
61type I interferon signaling pathway (GO:0060337)2.83210865
62cellular response to type I interferon (GO:0071357)2.83210865
63regulation of natural killer cell differentiation (GO:0032823)2.81607085
64response to interferon-alpha (GO:0035455)2.80676337
65negative regulation of norepinephrine secretion (GO:0010700)2.80379390
66regulation of axon guidance (GO:1902667)2.79639543
67negative regulation of erythrocyte differentiation (GO:0045647)2.77881954
68bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77008483
69surfactant homeostasis (GO:0043129)2.75275999
70adhesion of symbiont to host (GO:0044406)2.73346779
71detection of other organism (GO:0098543)2.72479033
72negative regulation of metanephros development (GO:0072217)2.71909651
73detection of molecule of bacterial origin (GO:0032490)2.69331563
74negative regulation of protein autophosphorylation (GO:0031953)2.68078308
75response to gravity (GO:0009629)2.67219427
76locomotory exploration behavior (GO:0035641)2.66387867
77kynurenine metabolic process (GO:0070189)2.64375811
78vascular endothelial growth factor signaling pathway (GO:0038084)2.64262013
79complement activation (GO:0006956)2.63591808
80positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62583019
81cellular response to interferon-beta (GO:0035458)2.62557448
82detection of bacterium (GO:0016045)2.62416317
83negative regulation of complement activation (GO:0045916)2.62008076
84complement activation, classical pathway (GO:0006958)2.61266513
85L-fucose catabolic process (GO:0042355)2.59386254
86fucose catabolic process (GO:0019317)2.59386254
87L-fucose metabolic process (GO:0042354)2.59386254
88positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59017988
89phagocytosis, engulfment (GO:0006911)2.58978644
90glomerular filtration (GO:0003094)2.58659188
91positive regulation of odontogenesis (GO:0042482)2.58306974
92regulation of T cell mediated cytotoxicity (GO:0001914)2.58270888
93ovulation from ovarian follicle (GO:0001542)2.57798698
94regulation of antigen processing and presentation (GO:0002577)2.56161181
95lymphangiogenesis (GO:0001946)2.55958171
96arginine catabolic process (GO:0006527)2.55405190
97detection of external biotic stimulus (GO:0098581)2.54952577
98cellular response to exogenous dsRNA (GO:0071360)2.54599577
99regulation of endothelial cell differentiation (GO:0045601)2.54294745
100secretory granule organization (GO:0033363)2.51835789
101regulation of T-helper 1 cell differentiation (GO:0045625)2.51301778
102hemidesmosome assembly (GO:0031581)2.51189432
103phosphatidylinositol acyl-chain remodeling (GO:0036149)2.50722194
104cellular response to dexamethasone stimulus (GO:0071549)2.49320427
105positive regulation of vasculogenesis (GO:2001214)2.47400345
106drug catabolic process (GO:0042737)2.46399680
107indolalkylamine metabolic process (GO:0006586)2.46006322
108facial nerve structural organization (GO:0021612)2.45483932
109regulation of vasculogenesis (GO:2001212)2.45459504
110regulation of macrophage derived foam cell differentiation (GO:0010743)2.45432602
111peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44440655
112regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.43894975
113response to corticosterone (GO:0051412)2.43431484
114smooth muscle tissue development (GO:0048745)2.42529122
115induction of positive chemotaxis (GO:0050930)2.41606126
116somite development (GO:0061053)2.41514285
117negative regulation of nitric-oxide synthase activity (GO:0051001)2.41033056
118gland morphogenesis (GO:0022612)2.40362115
119positive regulation of granulocyte chemotaxis (GO:0071624)2.39846352
120negative regulation of protein localization to cell surface (GO:2000009)2.39193476
121regulation of dopamine secretion (GO:0014059)2.38985230
122epithelial cell differentiation involved in kidney development (GO:0035850)2.38627112
123tryptophan metabolic process (GO:0006568)2.38151644
124positive regulation of defense response to virus by host (GO:0002230)2.38103425
125cellular response to thyroid hormone stimulus (GO:0097067)2.36002856
126regulation of glucocorticoid secretion (GO:2000849)2.35805252
127positive regulation of natural killer cell activation (GO:0032816)2.35728512
128definitive hemopoiesis (GO:0060216)2.35307397
129keratan sulfate catabolic process (GO:0042340)2.35218402
130RNA destabilization (GO:0050779)2.34818713
131renal filtration (GO:0097205)2.33500143
132negative regulation of interleukin-10 production (GO:0032693)2.33445387
133epoxygenase P450 pathway (GO:0019373)2.32063029
134protein activation cascade (GO:0072376)2.31549450
135negative regulation of humoral immune response (GO:0002921)2.31545650
136drug metabolic process (GO:0017144)2.30695858
137cellular response to cadmium ion (GO:0071276)2.30057519
138positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.29842467
139gonadal mesoderm development (GO:0007506)2.29742893
140vitamin A metabolic process (GO:0006776)2.29623210
141exogenous drug catabolic process (GO:0042738)2.29610068
142cell differentiation involved in kidney development (GO:0061005)2.29212328
143arginine metabolic process (GO:0006525)2.29006767
144detection of light stimulus involved in visual perception (GO:0050908)2.28943026
145detection of light stimulus involved in sensory perception (GO:0050962)2.28943026
146mesonephros development (GO:0001823)2.28683826
147regulation of neutrophil chemotaxis (GO:0090022)2.28627943
148regulation of neutrophil migration (GO:1902622)2.28627943
149low-density lipoprotein particle remodeling (GO:0034374)2.27912573
150regulation of monocyte chemotaxis (GO:0090025)2.27718250
151alanine transport (GO:0032328)2.26865633
152phenol-containing compound catabolic process (GO:0019336)2.26359752
153regulation of steroid hormone secretion (GO:2000831)2.25359457
154central nervous system myelination (GO:0022010)2.25193163
155axon ensheathment in central nervous system (GO:0032291)2.25193163
156positive regulation of smooth muscle cell migration (GO:0014911)2.24283458
157response to dexamethasone (GO:0071548)2.23517969
158regulation of cytokine production involved in inflammatory response (GO:1900015)2.23094451
159positive regulation of metanephros development (GO:0072216)2.23022648
160regulation of activation of Janus kinase activity (GO:0010533)2.22350888
161positive regulation of neutrophil chemotaxis (GO:0090023)2.22051018
162positive regulation of neutrophil migration (GO:1902624)2.22051018
163response to mineralocorticoid (GO:0051385)2.21682168
164regulation of triglyceride catabolic process (GO:0010896)2.20367371
165aromatic amino acid family catabolic process (GO:0009074)2.20299668
166positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.17846928
167regulation of T-helper 1 type immune response (GO:0002825)2.17276120
168macrophage differentiation (GO:0030225)2.16715089
169circadian sleep/wake cycle process (GO:0022410)2.16480968
170chemical homeostasis within a tissue (GO:0048875)2.15881699
171regulation of digestive system process (GO:0044058)2.15594079
172positive regulation of T-helper cell differentiation (GO:0045624)2.15097482
173regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.14881449
174cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.14536176
175protein-lipid complex remodeling (GO:0034368)2.14211082
176macromolecular complex remodeling (GO:0034367)2.14211082
177plasma lipoprotein particle remodeling (GO:0034369)2.14211082
178acylglycerol homeostasis (GO:0055090)2.13978112
179triglyceride homeostasis (GO:0070328)2.13978112
180cell proliferation involved in kidney development (GO:0072111)2.13952068
181regulation of natural killer cell activation (GO:0032814)2.13766707
182positive regulation of axon extension (GO:0045773)2.13188637
183regulation of guanylate cyclase activity (GO:0031282)2.12818019
184retina vasculature morphogenesis in camera-type eye (GO:0061299)2.12698310
185behavioral response to ethanol (GO:0048149)2.11795244
186positive regulation of ion transmembrane transport (GO:0034767)2.11152233
187cellular ketone body metabolic process (GO:0046950)2.10677342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.22666034
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.66488887
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53387536
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14911812
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.11688872
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.08015724
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05319655
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04830384
9ZNF274_21170338_ChIP-Seq_K562_Hela2.01775959
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00399896
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98404546
12WT1_19549856_ChIP-ChIP_CCG9911_Human1.96113341
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94951802
14DROSHA_22980978_ChIP-Seq_HELA_Human1.94110471
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.91866718
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.91279004
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90346298
18GBX2_23144817_ChIP-Seq_PC3_Human1.84319391
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82353325
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81065081
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77092625
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73867846
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.73285719
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.73144729
25SCL_19346495_ChIP-Seq_HPC-7_Human1.71981449
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.69258605
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68695936
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68695936
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64964654
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64050719
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60337352
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57877559
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57299811
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54906031
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52858716
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51033036
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48639129
38VDR_22108803_ChIP-Seq_LS180_Human1.47883166
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47737335
40TAF15_26573619_Chip-Seq_HEK293_Human1.47584069
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46466801
42* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45499620
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.43259987
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39955507
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.38566975
46RUNX_20019798_ChIP-Seq_JUKART_Human1.38124942
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36468995
48* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34748912
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31902127
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31625972
51EZH2_22144423_ChIP-Seq_EOC_Human1.29241863
52CJUN_26792858_Chip-Seq_BT549_Human1.29104738
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.28919554
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.27813104
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27554303
56* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26113306
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26063375
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25915278
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25791082
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24723381
61VDR_24787735_ChIP-Seq_THP-1_Human1.24483026
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.24414280
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23924834
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23924834
65GATA1_22025678_ChIP-Seq_K562_Human1.22878372
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21660848
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20645983
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20334467
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19244127
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18784320
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18783206
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.18676899
73SOX2_20726797_ChIP-Seq_SW620_Human1.18120962
74ER_23166858_ChIP-Seq_MCF-7_Human1.17505847
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17292976
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16774609
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16482385
78TP53_18474530_ChIP-ChIP_U2OS_Human1.15563648
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14231949
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13415929
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12532121
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11377913
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10467804
84RXR_22108803_ChIP-Seq_LS180_Human1.09711853
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08959838
86* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08413574
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.06717017
88P300_19829295_ChIP-Seq_ESCs_Human1.06454601
89FOXH1_21741376_ChIP-Seq_ESCs_Human1.06078425
90* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05891370
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05400794
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05124166
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04726055
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03965600
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.03549219
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02920959
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02758925
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.02688670
99AHR_22903824_ChIP-Seq_MCF-7_Human1.01683586
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.99534360
101* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99276253
102ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99270999
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.98405104
104EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98331595
105GATA3_21878914_ChIP-Seq_MCF-7_Human0.98256286
106AR_25329375_ChIP-Seq_VCAP_Human0.97859963
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97852107
108ERA_21632823_ChIP-Seq_H3396_Human0.97403444
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96844903
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96765635
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96757293
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96360079
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94529279
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93341961
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92730536
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92232318
117STAT3_23295773_ChIP-Seq_U87_Human0.92022532
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.91855457
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91372518
120AR_20517297_ChIP-Seq_VCAP_Human0.91197653
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.91195374
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91195374
123STAT1_20625510_ChIP-Seq_HELA_Human0.90774761
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90742189
125KDM2B_26808549_Chip-Seq_REH_Human0.90702238
126NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90444266
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89361098
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89275109
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88231699
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88018283
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87561118
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.87470086
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87276417
134CDX2_22108803_ChIP-Seq_LS180_Human0.87047302
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86614081
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.86597365
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86360022
138SMAD4_21799915_ChIP-Seq_A2780_Human0.86139165
139OCT4_20526341_ChIP-Seq_ESCs_Human0.86001806
140TCF4_22108803_ChIP-Seq_LS180_Human0.85975994
141NANOG_20526341_ChIP-Seq_ESCs_Human0.85812431
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85568242
143BCAT_22108803_ChIP-Seq_LS180_Human0.85383481
144TCF4_23295773_ChIP-Seq_U87_Human0.85221744
145TAF2_19829295_ChIP-Seq_ESCs_Human0.84884975
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84800094
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.83568488
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83418819
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83317870
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.83060696
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82531468
152CDX2_20551321_ChIP-Seq_CACO-2_Human0.81814646
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81116532
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79003358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.61136008
2MP0008438_abnormal_cutaneous_collagen4.47469590
3MP0003724_increased_susceptibility_to3.00691748
4MP0000685_abnormal_immune_system2.85159776
5MP0003011_delayed_dark_adaptation2.74144489
6MP0005503_abnormal_tendon_morphology2.72724320
7MP0005275_abnormal_skin_tensile2.64827843
8MP0001835_abnormal_antigen_presentation2.48572131
9MP0003195_calcinosis2.38790553
10MP0009785_altered_susceptibility_to2.37536000
11MP0004272_abnormal_basement_membrane2.30265723
12MP0001501_abnormal_sleep_pattern2.25089330
13MP0005360_urolithiasis2.17157470
14MP0001958_emphysema2.16361838
15MP0006082_CNS_inflammation2.07279113
16MP0008875_abnormal_xenobiotic_pharmacok2.07009985
17MP0001879_abnormal_lymphatic_vessel1.99422086
18MP0004510_myositis1.98881844
19MP0008775_abnormal_heart_ventricle1.98761778
20MP0002148_abnormal_hypersensitivity_rea1.92990285
21MP0003279_aneurysm1.91348873
22MP0005551_abnormal_eye_electrophysiolog1.88043116
23MP0005387_immune_system_phenotype1.87407433
24MP0001790_abnormal_immune_system1.87407433
25MP0001346_abnormal_lacrimal_gland1.86996348
26MP0002876_abnormal_thyroid_physiology1.82560057
27MP0001542_abnormal_bone_strength1.81524889
28MP0010329_abnormal_lipoprotein_level1.78306444
29MP0010368_abnormal_lymphatic_system1.74905108
30MP0005671_abnormal_response_to1.70763118
31MP0005025_abnormal_response_to1.70561882
32MP0004381_abnormal_hair_follicle1.65999274
33MP0005365_abnormal_bile_salt1.62233355
34MP0003646_muscle_fatigue1.60391286
35MP0002419_abnormal_innate_immunity1.60227164
36MP0000920_abnormal_myelination1.54755440
37MP0009379_abnormal_foot_pigmentation1.52877822
38MP0000013_abnormal_adipose_tissue1.49887892
39MP0001851_eye_inflammation1.46779620
40MP0004215_abnormal_myocardial_fiber1.44791408
41MP0004043_abnormal_pH_regulation1.44155632
42MP0000681_abnormal_thyroid_gland1.44081166
43MP0005000_abnormal_immune_tolerance1.42730268
44MP0001873_stomach_inflammation1.40773674
45MP0002166_altered_tumor_susceptibility1.36903303
46MP0003329_amyloid_beta_deposits1.36370348
47MP0001502_abnormal_circadian_rhythm1.33636343
48MP0001800_abnormal_humoral_immune1.33347901
49MP0002060_abnormal_skin_morphology1.32642801
50MP0001545_abnormal_hematopoietic_system1.32082872
51MP0005397_hematopoietic_system_phenotyp1.32082872
52MP0003436_decreased_susceptibility_to1.31962930
53MP0000343_altered_response_to1.29000947
54MP0004084_abnormal_cardiac_muscle1.28720651
55MP0002138_abnormal_hepatobiliary_system1.28079636
56MP0002452_abnormal_antigen_presenting1.28021185
57MP0002723_abnormal_immune_serum1.27603270
58MP0009764_decreased_sensitivity_to1.22604620
59MP0000465_gastrointestinal_hemorrhage1.22495544
60MP0000383_abnormal_hair_follicle1.21216730
61MP0005409_darkened_coat_color1.20864802
62MP0005310_abnormal_salivary_gland1.19903027
63MP0001661_extended_life_span1.19327124
64MP0004130_abnormal_muscle_cell1.18850615
65MP0002420_abnormal_adaptive_immunity1.17246002
66MP0003950_abnormal_plasma_membrane1.17158691
67MP0002933_joint_inflammation1.16693144
68MP0002277_abnormal_respiratory_mucosa1.16451095
69MP0000767_abnormal_smooth_muscle1.16088277
70MP0009840_abnormal_foam_cell1.15605770
71MP0001819_abnormal_immune_cell1.15315677
72MP0003763_abnormal_thymus_physiology1.14799492
73MP0005670_abnormal_white_adipose1.14552764
74MP0002837_dystrophic_cardiac_calcinosis1.12300971
75MP0001986_abnormal_taste_sensitivity1.12061956
76MP0005085_abnormal_gallbladder_physiolo1.09554277
77MP0005646_abnormal_pituitary_gland1.08490749
78MP0002009_preneoplasia1.08393680
79MP0003045_fibrosis1.08273884
80MP0001533_abnormal_skeleton_physiology1.08072491
81MP0005464_abnormal_platelet_physiology1.07911929
82MP0002971_abnormal_brown_adipose1.06579666
83MP0006276_abnormal_autonomic_nervous1.06177209
84MP0006054_spinal_hemorrhage1.05686636
85MP0005332_abnormal_amino_acid1.05269183
86MP0003828_pulmonary_edema1.03940796
87MP0009384_cardiac_valve_regurgitation1.03488340
88* MP0001845_abnormal_inflammatory_respons1.02349819
89MP0004858_abnormal_nervous_system1.02165288
90MP0004019_abnormal_vitamin_homeostasis1.01855491
91MP0000003_abnormal_adipose_tissue1.01419590
92MP0005623_abnormal_meninges_morphology1.00756904
93MP0005647_abnormal_sex_gland0.98648631
94MP0005253_abnormal_eye_physiology0.97977866
95MP0002006_tumorigenesis0.97067888
96MP0002133_abnormal_respiratory_system0.96329301
97MP0005388_respiratory_system_phenotype0.96329301
98MP0002108_abnormal_muscle_morphology0.96208046
99MP0005164_abnormal_response_to0.96170119
100MP0002998_abnormal_bone_remodeling0.95224562
101MP0009278_abnormal_bone_marrow0.94004757
102MP0005448_abnormal_energy_balance0.93134661
103MP0008872_abnormal_physiological_respon0.92641023
104MP0004782_abnormal_surfactant_physiolog0.92313629
105MP0003137_abnormal_impulse_conducting0.91305401
106MP0008004_abnormal_stomach_pH0.90971105
107MP0010155_abnormal_intestine_physiology0.89953775
108MP0008469_abnormal_protein_level0.89188193
109MP0004085_abnormal_heartbeat0.88736046
110MP0009780_abnormal_chondrocyte_physiolo0.88082717
111MP0005165_increased_susceptibility_to0.88049316
112MP0005535_abnormal_body_temperature0.87914243
113MP0009643_abnormal_urine_homeostasis0.87253958
114MP0001756_abnormal_urination0.87094235
115MP0001968_abnormal_touch/_nociception0.86977123
116MP0002295_abnormal_pulmonary_circulatio0.86775075
117MP0004036_abnormal_muscle_relaxation0.86640221
118MP0003959_abnormal_lean_body0.86626598
119MP0005390_skeleton_phenotype0.86132500
120MP0002405_respiratory_system_inflammati0.85499794
121MP0000604_amyloidosis0.83937774
122MP0000716_abnormal_immune_system0.83847074
123MP0004484_altered_response_of0.83821672
124MP0000566_synostosis0.82902209
125MP0002733_abnormal_thermal_nociception0.82180056
126MP0009333_abnormal_splenocyte_physiolog0.81443702
127MP0003690_abnormal_glial_cell0.81183000
128MP0004147_increased_porphyrin_level0.80676860
129MP0005508_abnormal_skeleton_morphology0.79994930
130MP0002118_abnormal_lipid_homeostasis0.79942188
131MP0005620_abnormal_muscle_contractility0.79930436
132MP0006138_congestive_heart_failure0.79488856
133MP0003638_abnormal_response/metabolism_0.79422277
134MP0000678_abnormal_parathyroid_gland0.79123147
135MP0009745_abnormal_behavioral_response0.78050531
136MP0002127_abnormal_cardiovascular_syste0.77497149
137MP0005595_abnormal_vascular_smooth0.77385387
138MP0001919_abnormal_reproductive_system0.77131988
139MP0003075_altered_response_to0.76819373
140MP0004883_abnormal_blood_vessel0.76637883
141MP0002396_abnormal_hematopoietic_system0.74875431
142MP0009250_abnormal_appendicular_skeleto0.74183811
143MP0002972_abnormal_cardiac_muscle0.73800774
144MP0001905_abnormal_dopamine_level0.73514506
145MP0003448_altered_tumor_morphology0.71742262
146MP0005167_abnormal_blood-brain_barrier0.71636741
147MP0009046_muscle_twitch0.71383536
148MP0005075_abnormal_melanosome_morpholog0.71118609
149MP0005171_absent_coat_pigmentation0.71035271
150MP0002168_other_aberrant_phenotype0.70839963
151MP0003191_abnormal_cellular_cholesterol0.70455364
152MP0005375_adipose_tissue_phenotype0.70113700
153MP0000751_myopathy0.70018649
154MP0002249_abnormal_larynx_morphology0.69714053
155MP0001970_abnormal_pain_threshold0.69630377
156MP0000750_abnormal_muscle_regeneration0.69568095
157MP0000249_abnormal_blood_vessel0.69415534
158MP0000538_abnormal_urinary_bladder0.69403408
159MP0000613_abnormal_salivary_gland0.69014641
160MP0001853_heart_inflammation0.67678107
161MP0000230_abnormal_systemic_arterial0.65641293

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.35715626
2Abnormality of complement system (HP:0005339)4.32965670
3Increased corneal curvature (HP:0100692)4.21598856
4Keratoconus (HP:0000563)4.21598856
5Broad metatarsal (HP:0001783)4.04414994
6Myositis (HP:0100614)3.89330242
7Chronic otitis media (HP:0000389)3.59760689
8Systemic lupus erythematosus (HP:0002725)3.57978302
9Aortic dissection (HP:0002647)3.57330271
10Mesangial abnormality (HP:0001966)3.56084026
11Elevated erythrocyte sedimentation rate (HP:0003565)3.53814990
12Glomerulonephritis (HP:0000099)3.47282981
13Hypoproteinemia (HP:0003075)3.32866562
14Hypothermia (HP:0002045)3.21777385
15Polyphagia (HP:0002591)3.10658426
16Decreased circulating renin level (HP:0003351)3.07702675
17Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97551048
18Nephritis (HP:0000123)2.94478710
19Keratoconjunctivitis (HP:0001096)2.92081651
20Eczematoid dermatitis (HP:0000976)2.86391782
21Nasolacrimal duct obstruction (HP:0000579)2.84424901
22Orchitis (HP:0100796)2.83798535
23Right ventricular cardiomyopathy (HP:0011663)2.82046811
24Joint stiffness (HP:0001387)2.80606925
25Congenital sensorineural hearing impairment (HP:0008527)2.79529349
26Spontaneous hematomas (HP:0007420)2.78956770
27Recurrent abscess formation (HP:0002722)2.78545097
28Recurrent cutaneous fungal infections (HP:0011370)2.78403348
29Chronic mucocutaneous candidiasis (HP:0002728)2.78403348
30Premature rupture of membranes (HP:0001788)2.78394863
31Purpura (HP:0000979)2.75321505
32Bone cyst (HP:0012062)2.75265453
33Pulmonary artery stenosis (HP:0004415)2.73252136
34Retrobulbar optic neuritis (HP:0100654)2.70355908
35Optic neuritis (HP:0100653)2.70355908
36Weak cry (HP:0001612)2.66946105
37Ankle contracture (HP:0006466)2.66560751
38Hydroxyprolinuria (HP:0003080)2.65379499
39Abnormality of proline metabolism (HP:0010907)2.65379499
40Atrophic scars (HP:0001075)2.64327312
41Abnormality of the nasal mucosa (HP:0000433)2.61666537
42Hyperlipoproteinemia (HP:0010980)2.57179251
43Xanthomatosis (HP:0000991)2.56730660
44Pigmentary retinal degeneration (HP:0001146)2.56052410
45Recurrent bronchitis (HP:0002837)2.55600864
46Delayed CNS myelination (HP:0002188)2.55011712
47Aortic valve stenosis (HP:0001650)2.53696645
48Follicular hyperkeratosis (HP:0007502)2.51975387
49Hyperventilation (HP:0002883)2.50784787
50Facial shape deformation (HP:0011334)2.49246070
51Potter facies (HP:0002009)2.49246070
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48505167
53Widely patent fontanelles and sutures (HP:0004492)2.45941499
54Nonprogressive disorder (HP:0003680)2.43620386
55Recurrent skin infections (HP:0001581)2.37488155
56Abnormality of the columella (HP:0009929)2.37112465
57Abnormality of macrophages (HP:0004311)2.36688264
58Petechiae (HP:0000967)2.35440592
59Attenuation of retinal blood vessels (HP:0007843)2.34884469
60Interstitial pulmonary disease (HP:0006530)2.30262118
61Type II lissencephaly (HP:0007260)2.28464500
62Type 2 muscle fiber atrophy (HP:0003554)2.28256945
63Prolonged QT interval (HP:0001657)2.26859819
64Aortic aneurysm (HP:0004942)2.25846747
65Keratoconjunctivitis sicca (HP:0001097)2.25139432
66Large for gestational age (HP:0001520)2.24601544
67Recurrent bacterial skin infections (HP:0005406)2.24125956
68Onycholysis (HP:0001806)2.23955626
69Chronic sinusitis (HP:0011109)2.23660562
70Pancreatic cysts (HP:0001737)2.22960067
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.21528124
72Metaphyseal dysplasia (HP:0100255)2.19288324
73Arterial tortuosity (HP:0005116)2.15831853
74Premature skin wrinkling (HP:0100678)2.15434099
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14636230
76Abnormality of alanine metabolism (HP:0010916)2.14636230
77Hyperalaninemia (HP:0003348)2.14636230
78Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.14259156
79Spondylolisthesis (HP:0003302)2.14147469
80Hematochezia (HP:0002573)2.14022229
81Congenital, generalized hypertrichosis (HP:0004540)2.12335343
82Tubular atrophy (HP:0000092)2.09282713
83Mediastinal lymphadenopathy (HP:0100721)2.08029080
84Parakeratosis (HP:0001036)2.07502976
85Prominent supraorbital ridges (HP:0000336)2.07433861
86Gastrointestinal stroma tumor (HP:0100723)2.07368274
87Opisthotonus (HP:0002179)2.06482700
88Abnormality of the renal cortex (HP:0011035)2.04735771
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03616496
90Abnormality of the costochondral junction (HP:0000919)2.02817182
91Wrist flexion contracture (HP:0001239)2.02436070
92Panhypogammaglobulinemia (HP:0003139)2.00472472
93Soft skin (HP:0000977)2.00011852
94Vertebral compression fractures (HP:0002953)1.99472541
95Molar tooth sign on MRI (HP:0002419)1.99461683
96Abnormality of midbrain morphology (HP:0002418)1.99461683
97Abolished electroretinogram (ERG) (HP:0000550)1.97977912
98Cystic liver disease (HP:0006706)1.97972890
99Short hallux (HP:0010109)1.96620578
100Retinal dysplasia (HP:0007973)1.96002331
101Abnormality of renin-angiotensin system (HP:0000847)1.95635963
102Clumsiness (HP:0002312)1.95583751
103Fragile skin (HP:0001030)1.95256491
104Aortic regurgitation (HP:0001659)1.95189383
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.94776898
106Malnutrition (HP:0004395)1.94145217
107Vascular tortuosity (HP:0004948)1.93721206
108Aplasia cutis congenita (HP:0001057)1.93572667
109Abnormality of the frontal sinuses (HP:0002687)1.93035806
110Metabolic alkalosis (HP:0200114)1.92428263
111Atrial fibrillation (HP:0005110)1.92417553
112Hypoplasia of the iris (HP:0007676)1.92120210
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91405169
114Abnormality of polysaccharide metabolism (HP:0011012)1.91405169
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91405169
116Complement deficiency (HP:0004431)1.90823269
117Ventricular tachycardia (HP:0004756)1.90626988
118Abnormal eating behavior (HP:0100738)1.90603502
119Stridor (HP:0010307)1.90598750
120Hemoptysis (HP:0002105)1.90497232
121Polydipsia (HP:0001959)1.90399322
122Abnormal drinking behavior (HP:0030082)1.90399322
123Corneal dystrophy (HP:0001131)1.89901407
124Eosinophilia (HP:0001880)1.89868043
125Abnormality of the nasolacrimal system (HP:0000614)1.89402805
126Abnormality of molar morphology (HP:0011070)1.89147003
127Abnormality of molar (HP:0011077)1.89147003
128Lymphangioma (HP:0100764)1.88911323
129Abnormal albumin level (HP:0012116)1.88846968
130Hypoalbuminemia (HP:0003073)1.88846968
131Autoimmune thrombocytopenia (HP:0001973)1.88594860
132Inability to walk (HP:0002540)1.87686585
133Bradycardia (HP:0001662)1.87613135
134Abnormal urine output (HP:0012590)1.87381988
135Type 1 muscle fiber predominance (HP:0003803)1.87293572
136Vacuolated lymphocytes (HP:0001922)1.86713721
137Abnormality of the lacrimal duct (HP:0011481)1.86412030
138Abnormal hair whorl (HP:0010721)1.86408264
139Delayed closure of the anterior fontanelle (HP:0001476)1.86188650
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84297395
141Absent speech (HP:0001344)1.84245177
142Amyloidosis (HP:0011034)1.83918270
143Thyroid-stimulating hormone excess (HP:0002925)1.83676130
144Meningitis (HP:0001287)1.83212002
145Hepatosplenomegaly (HP:0001433)1.82971018
146Vasculitis (HP:0002633)1.81540809
147Bulbous nose (HP:0000414)1.81470430
148Muscle fiber atrophy (HP:0100295)1.81449381
149Decreased central vision (HP:0007663)1.80844780
150Facial diplegia (HP:0001349)1.80836653
151Milia (HP:0001056)1.80093375
152Cerebral hemorrhage (HP:0001342)1.79652812
153Chondrocalcinosis (HP:0000934)1.79327498
154Protrusio acetabuli (HP:0003179)1.78929219
155Peritonitis (HP:0002586)1.78847541
156Syncope (HP:0001279)1.78679187
157Stage 5 chronic kidney disease (HP:0003774)1.76453227
158Ulnar claw (HP:0001178)1.76163082
159Abnormality of the renal medulla (HP:0100957)1.76054280
160Myocardial infarction (HP:0001658)1.74963421
161Inflammation of the large intestine (HP:0002037)1.74583245
162Nephronophthisis (HP:0000090)1.74371260
163Abnormal pupillary function (HP:0007686)1.73618029
164Abnormality of Sharpey fibers (HP:0100685)1.73464710
165Primary atrial arrhythmia (HP:0001692)1.73077347
166White forelock (HP:0002211)1.72692359
167Abnormal glucose tolerance (HP:0001952)1.72607564
168Patchy hypopigmentation of hair (HP:0011365)1.72564460
169Recurrent fungal infections (HP:0002841)1.72549902
170Asymmetric septal hypertrophy (HP:0001670)1.71997185
171Abnormality of dentin (HP:0010299)1.71861075
172Mucopolysacchariduria (HP:0008155)1.71438598
173Dysostosis multiplex (HP:0000943)1.70207738
174Cerebral palsy (HP:0100021)1.69126653
175Palpebral edema (HP:0100540)1.68575677
176True hermaphroditism (HP:0010459)1.68385480
177Stomach cancer (HP:0012126)1.68122343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.14895325
2TGFBR24.55352789
3KIT3.19565704
4MYLK3.14584905
5ERN13.03804772
6MAPK152.67324796
7TNIK2.64698774
8EPHB12.42864826
9TEC2.35919962
10TIE12.30445235
11MAPKAPK52.26716407
12TYK22.26095040
13PINK12.03570890
14BTK1.88585941
15ACVR1B1.87543840
16MAPKAPK31.85970302
17MUSK1.84712251
18EPHB21.73479841
19ADRBK11.72098472
20DAPK21.71924555
21TXK1.65791791
22MAP4K21.64444474
23TGFBR11.63635226
24NLK1.57751918
25CASK1.56866173
26WNK41.56476397
27INSRR1.55144558
28ADRBK21.51709712
29TBK11.51702283
30IKBKE1.50227651
31MAP3K141.44121694
32IRAK41.43982507
33MST41.43552731
34FLT31.42561535
35CAMK1D1.40443401
36LIMK11.39727979
37FER1.34598071
38ITK1.32786806
39CSF1R1.31964379
40CLK11.31032631
41STK391.28011506
42JAK31.23016459
43GRK71.22962199
44ERBB31.18582805
45MAP4K11.18525546
46ZAP701.18077283
47PHKG21.14836971
48PHKG11.14836971
49SIK21.14584089
50WNK31.14514442
51ABL21.12366049
52IRAK31.09097480
53PKN11.08970345
54PIK3CG1.08937800
55MAP3K121.04497318
56LMTK21.04135337
57EPHA31.03299636
58CDC42BPA1.02513969
59TRPM71.00988404
60MAP2K21.00438456
61BMPR21.00385622
62GRK11.00110137
63IKBKB0.99864153
64KDR0.97976993
65OXSR10.97074663
66CAMK1G0.96089326
67JAK10.93447182
68CAMK40.93320543
69TTN0.93215387
70CAMKK20.93046288
71CAMK10.92074797
72MAPK70.90462987
73PAK30.90409556
74DDR20.89589200
75NTRK30.89200562
76TAOK30.88472027
77PIK3CA0.88442016
78FGFR40.88105518
79BLK0.87200086
80MET0.86932073
81LCK0.85922389
82BMPR1B0.85343964
83SYK0.83052774
84FGFR20.82349390
85TESK10.81738427
86FES0.81717229
87FGR0.79410908
88PRKD10.79203994
89MAPK130.78767184
90PRKAA20.78672995
91IRAK10.76783844
92MAP3K130.76319419
93CSK0.73148898
94MARK10.73121694
95MATK0.70701665
96VRK10.70536794
97HCK0.70073728
98DYRK1B0.69989735
99PRKCG0.69305754
100DAPK30.69178509
101PAK20.67630499
102MKNK10.64892128
103CHUK0.64710181
104MAPK120.64523967
105PTK2B0.64422100
106CDK30.63820184
107NUAK10.61622539
108TNK20.61321206
109TLK10.60547959
110ROCK10.59740648
111MAPK40.59188169
112CAMK2A0.59049082
113MOS0.58835870
114LYN0.57212752
115CDK190.56411354
116MAPKAPK20.55908612
117RPS6KA50.55248202
118MAP2K10.55156602
119MAP3K70.54995831
120GRK50.54975960
121PRKD20.54830981
122PRKCE0.54222274
123PDGFRA0.54153799
124MAP3K30.52996530
125IGF1R0.52171389
126STK380.50864074
127CAMK2B0.50796450
128RIPK10.50197321
129MAP3K110.49978249
130MAP3K60.49899021
131MAP2K60.48760609
132PRKG20.48760185
133HIPK20.47497231
134MARK20.47209829
135PRKACA0.46800747
136PDGFRB0.46071490
137ZAK0.45401500
138NME20.45211787
139FGFR30.44984097
140ROCK20.44436794
141CAMK2G0.44325731
142PRKCA0.43696292
143EPHA20.43682678
144RPS6KA20.42488574
145PRKG10.42314032
146PTK20.42020292
147BCKDK0.41965405
148RPS6KA60.41226099
149CAMK2D0.41102875
150DYRK20.40271134
151SIK30.40225668
152JAK20.40064721
153PRKACG0.37524615
154OBSCN0.36643281

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003802.41490912
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16985780
3ECM-receptor interaction_Homo sapiens_hsa045122.16653845
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14891782
5Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.08426472
6Staphylococcus aureus infection_Homo sapiens_hsa051502.06401736
7Sulfur relay system_Homo sapiens_hsa041222.04258153
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01685776
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.92941351
10Rheumatoid arthritis_Homo sapiens_hsa053231.86424342
11Autoimmune thyroid disease_Homo sapiens_hsa053201.85570442
12Hematopoietic cell lineage_Homo sapiens_hsa046401.84748618
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.80497712
14Primary immunodeficiency_Homo sapiens_hsa053401.79334842
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.75334118
16Protein export_Homo sapiens_hsa030601.75102737
17Chemical carcinogenesis_Homo sapiens_hsa052041.74164062
18Osteoclast differentiation_Homo sapiens_hsa043801.72446580
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.67595286
20PPAR signaling pathway_Homo sapiens_hsa033201.65877356
21Retinol metabolism_Homo sapiens_hsa008301.64644648
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63295902
23Phototransduction_Homo sapiens_hsa047441.61486136
24Pertussis_Homo sapiens_hsa051331.61012901
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.60678169
26Folate biosynthesis_Homo sapiens_hsa007901.60447693
27Allograft rejection_Homo sapiens_hsa053301.60265970
28Fatty acid elongation_Homo sapiens_hsa000621.58338169
29Leishmaniasis_Homo sapiens_hsa051401.55315197
30Fat digestion and absorption_Homo sapiens_hsa049751.52469009
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.51073089
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50673255
33Butanoate metabolism_Homo sapiens_hsa006501.50106415
34Malaria_Homo sapiens_hsa051441.49772790
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48008513
36Glycerolipid metabolism_Homo sapiens_hsa005611.46230999
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46095189
38* Arachidonic acid metabolism_Homo sapiens_hsa005901.41650882
39Graft-versus-host disease_Homo sapiens_hsa053321.38518761
40Nitrogen metabolism_Homo sapiens_hsa009101.37439100
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36831046
42Other glycan degradation_Homo sapiens_hsa005111.32576747
43Mineral absorption_Homo sapiens_hsa049781.31432892
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29320626
45Caffeine metabolism_Homo sapiens_hsa002321.27696609
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27577464
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27364474
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25235447
49Focal adhesion_Homo sapiens_hsa045101.24051853
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22311965
51Amoebiasis_Homo sapiens_hsa051461.21277453
52Sulfur metabolism_Homo sapiens_hsa009201.20070707
53Asthma_Homo sapiens_hsa053101.19677382
54Fatty acid degradation_Homo sapiens_hsa000711.19416006
55Toxoplasmosis_Homo sapiens_hsa051451.19152738
56Oxidative phosphorylation_Homo sapiens_hsa001901.17892667
57Antigen processing and presentation_Homo sapiens_hsa046121.17358471
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16107326
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15547557
60Phenylalanine metabolism_Homo sapiens_hsa003601.15485841
61Tyrosine metabolism_Homo sapiens_hsa003501.15117287
62Ether lipid metabolism_Homo sapiens_hsa005651.11961848
63Measles_Homo sapiens_hsa051621.11843820
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11384594
65Morphine addiction_Homo sapiens_hsa050321.10349188
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09543615
67Tuberculosis_Homo sapiens_hsa051521.09086245
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.05607845
69African trypanosomiasis_Homo sapiens_hsa051431.03093474
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01330881
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00572450
72Renin-angiotensin system_Homo sapiens_hsa046140.99918876
73Parkinsons disease_Homo sapiens_hsa050120.98164898
74Alzheimers disease_Homo sapiens_hsa050100.97901857
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97559166
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97292529
77Phagosome_Homo sapiens_hsa041450.96809057
78Salmonella infection_Homo sapiens_hsa051320.96787267
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.96730637
80Salivary secretion_Homo sapiens_hsa049700.96418732
81Bile secretion_Homo sapiens_hsa049760.96138821
82Dilated cardiomyopathy_Homo sapiens_hsa054140.95530738
83Peroxisome_Homo sapiens_hsa041460.93876464
84Histidine metabolism_Homo sapiens_hsa003400.91838838
85beta-Alanine metabolism_Homo sapiens_hsa004100.90688400
86Arginine biosynthesis_Homo sapiens_hsa002200.87948793
87B cell receptor signaling pathway_Homo sapiens_hsa046620.85570428
88Sphingolipid metabolism_Homo sapiens_hsa006000.84971704
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84909383
90Platelet activation_Homo sapiens_hsa046110.84790234
91Arginine and proline metabolism_Homo sapiens_hsa003300.84764092
92Insulin secretion_Homo sapiens_hsa049110.84098400
93Notch signaling pathway_Homo sapiens_hsa043300.82498887
94Influenza A_Homo sapiens_hsa051640.82466634
95Chemokine signaling pathway_Homo sapiens_hsa040620.80646511
96Viral myocarditis_Homo sapiens_hsa054160.79466372
97Herpes simplex infection_Homo sapiens_hsa051680.78953719
98Circadian entrainment_Homo sapiens_hsa047130.78737080
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78291366
100Ribosome_Homo sapiens_hsa030100.76093237
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76013446
102Ras signaling pathway_Homo sapiens_hsa040140.75925485
103TNF signaling pathway_Homo sapiens_hsa046680.75847697
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75049535
105Linoleic acid metabolism_Homo sapiens_hsa005910.74853033
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74448883
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73700745
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73648359
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71283372
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.69595850
111Cardiac muscle contraction_Homo sapiens_hsa042600.69322097
112GABAergic synapse_Homo sapiens_hsa047270.69265463
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69041875
114Taste transduction_Homo sapiens_hsa047420.68438918
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68426962
116Nicotine addiction_Homo sapiens_hsa050330.68153425
117Selenocompound metabolism_Homo sapiens_hsa004500.67425683
118Legionellosis_Homo sapiens_hsa051340.67199754
119Small cell lung cancer_Homo sapiens_hsa052220.65840234
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65417675
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64966190
122Glutamatergic synapse_Homo sapiens_hsa047240.64539037
123Hepatitis C_Homo sapiens_hsa051600.63076508
124Olfactory transduction_Homo sapiens_hsa047400.63002552
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62963728
126Complement and coagulation cascades_Homo sapiens_hsa046100.61785902
127Renin secretion_Homo sapiens_hsa049240.61496056
128Lysosome_Homo sapiens_hsa041420.61250005
129Rap1 signaling pathway_Homo sapiens_hsa040150.61212559
130Pathways in cancer_Homo sapiens_hsa052000.59787050
131Ovarian steroidogenesis_Homo sapiens_hsa049130.59379592
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58238562
133Starch and sucrose metabolism_Homo sapiens_hsa005000.57744247
134Protein digestion and absorption_Homo sapiens_hsa049740.56825589
135Serotonergic synapse_Homo sapiens_hsa047260.55532552
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.55327495
137Collecting duct acid secretion_Homo sapiens_hsa049660.54759754
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54473015
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.53930584
140Hepatitis B_Homo sapiens_hsa051610.52190827
141Shigellosis_Homo sapiens_hsa051310.51211147
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51008256
143ABC transporters_Homo sapiens_hsa020100.50311643
144T cell receptor signaling pathway_Homo sapiens_hsa046600.49018217
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.48830904
146Axon guidance_Homo sapiens_hsa043600.48115092
147Pancreatic secretion_Homo sapiens_hsa049720.45527713
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45467793
149Vitamin digestion and absorption_Homo sapiens_hsa049770.43888055
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43125571
151* Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42567151
152Calcium signaling pathway_Homo sapiens_hsa040200.42007101
153Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40282821
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39994097
155* Cyanoamino acid metabolism_Homo sapiens_hsa004600.37337342
156TGF-beta signaling pathway_Homo sapiens_hsa043500.37237885
157Gastric acid secretion_Homo sapiens_hsa049710.36011501
158* Metabolic pathways_Homo sapiens_hsa011000.35475987

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »