GGT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17251022
2synaptic vesicle maturation (GO:0016188)6.02364420
3synaptic vesicle exocytosis (GO:0016079)5.51672220
4locomotory exploration behavior (GO:0035641)5.33625687
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32481784
6glutamate secretion (GO:0014047)5.32326327
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23861300
8regulation of synaptic vesicle exocytosis (GO:2000300)5.18768714
9vocalization behavior (GO:0071625)5.08389097
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.01457527
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01427653
12neuronal action potential propagation (GO:0019227)4.67738263
13regulation of glutamate receptor signaling pathway (GO:1900449)4.67040614
14protein localization to synapse (GO:0035418)4.66826655
15regulation of synaptic vesicle transport (GO:1902803)4.56556014
16neurotransmitter secretion (GO:0007269)4.52220576
17neuron cell-cell adhesion (GO:0007158)4.44731929
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.34232030
19regulation of neuronal synaptic plasticity (GO:0048168)4.30501436
20exploration behavior (GO:0035640)4.23863622
21synaptic transmission, glutamatergic (GO:0035249)4.11064375
22regulation of synapse structural plasticity (GO:0051823)4.09953401
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04445515
24cellular potassium ion homeostasis (GO:0030007)4.03438581
25neurotransmitter-gated ion channel clustering (GO:0072578)4.01273545
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99898323
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95502962
28neuron-neuron synaptic transmission (GO:0007270)3.92158649
29glutamate receptor signaling pathway (GO:0007215)3.91897445
30proline transport (GO:0015824)3.91801107
31gamma-aminobutyric acid transport (GO:0015812)3.88694896
32sodium ion export (GO:0071436)3.83133909
33establishment of mitochondrion localization (GO:0051654)3.82115745
34layer formation in cerebral cortex (GO:0021819)3.80611882
35neurotransmitter transport (GO:0006836)3.64298253
36long-term memory (GO:0007616)3.63270102
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58402371
38positive regulation of synapse maturation (GO:0090129)3.57159560
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56976040
40neuromuscular process controlling posture (GO:0050884)3.54719581
41cerebellar Purkinje cell differentiation (GO:0021702)3.54503182
42positive regulation of membrane potential (GO:0045838)3.54264156
43regulation of synapse maturation (GO:0090128)3.53520826
44amino acid import (GO:0043090)3.52627026
45regulation of neurotransmitter secretion (GO:0046928)3.47017378
46regulation of synaptic plasticity (GO:0048167)3.46841778
47activation of protein kinase A activity (GO:0034199)3.46299474
48dendritic spine morphogenesis (GO:0060997)3.44918649
49transmission of nerve impulse (GO:0019226)3.44555195
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43402077
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.43358131
52mitochondrion transport along microtubule (GO:0047497)3.43358131
53regulation of postsynaptic membrane potential (GO:0060078)3.42971778
54regulation of ARF protein signal transduction (GO:0032012)3.42868185
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.41639236
56neuron recognition (GO:0008038)3.41497617
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.41231735
58synaptic vesicle endocytosis (GO:0048488)3.39894321
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38753594
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.38256173
61cell communication by electrical coupling (GO:0010644)3.36455554
62regulation of neurotransmitter levels (GO:0001505)3.35846450
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.35278272
64long-term synaptic potentiation (GO:0060291)3.35123153
65membrane depolarization during action potential (GO:0086010)3.34106200
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33828596
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.32334434
68neuromuscular process controlling balance (GO:0050885)3.29880220
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29253511
70postsynaptic membrane organization (GO:0001941)3.27166198
71L-amino acid import (GO:0043092)3.26837119
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26596259
73regulation of vesicle fusion (GO:0031338)3.23966059
74regulation of neurotransmitter transport (GO:0051588)3.23717621
75response to pheromone (GO:0019236)3.23665704
76axonal fasciculation (GO:0007413)3.23326108
77innervation (GO:0060384)3.22802539
78cell migration in hindbrain (GO:0021535)3.21264779
79dendrite morphogenesis (GO:0048813)3.17765470
80glycine transport (GO:0015816)3.17691033
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17513208
82response to auditory stimulus (GO:0010996)3.15746974
83membrane hyperpolarization (GO:0060081)3.15028743
84potassium ion homeostasis (GO:0055075)3.14614293
85auditory behavior (GO:0031223)3.14256872
86regulation of dendritic spine morphogenesis (GO:0061001)3.11266748
87membrane depolarization (GO:0051899)3.11241703
88positive regulation of neurotransmitter transport (GO:0051590)3.08095816
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07682716
90neuronal ion channel clustering (GO:0045161)3.05716436
91presynaptic membrane assembly (GO:0097105)3.03984095
92cerebellar granule cell differentiation (GO:0021707)3.00908467
93synapse assembly (GO:0007416)2.99876319
94synaptic transmission (GO:0007268)2.99416966
95regulation of synaptic transmission (GO:0050804)2.98292554
96cellular sodium ion homeostasis (GO:0006883)2.97152353
97positive regulation of neurotransmitter secretion (GO:0001956)2.96578507
98presynaptic membrane organization (GO:0097090)2.96551905
99mating behavior (GO:0007617)2.95599889
100learning (GO:0007612)2.95412292
101positive regulation of synaptic transmission (GO:0050806)2.94836680
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.94705265
103prepulse inhibition (GO:0060134)2.93523405
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92845150
105adult walking behavior (GO:0007628)2.92424851
106neuromuscular process (GO:0050905)2.91670196
107vesicle transport along microtubule (GO:0047496)2.90050632
108dendritic spine organization (GO:0097061)2.88904559
109regulation of voltage-gated calcium channel activity (GO:1901385)2.86248073
110calcium ion-dependent exocytosis (GO:0017156)2.86093325
111positive regulation of dendritic spine development (GO:0060999)2.85701407
112behavioral defense response (GO:0002209)2.84963760
113behavioral fear response (GO:0001662)2.84963760
114protein retention in ER lumen (GO:0006621)2.81354806
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.79924979
116regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73514418
117creatine metabolic process (GO:0006600)2.73282003
118cell-cell junction maintenance (GO:0045217)2.72496257
119cerebellar Purkinje cell layer development (GO:0021680)2.71979858
120central nervous system myelination (GO:0022010)2.62094164
121axon ensheathment in central nervous system (GO:0032291)2.62094164
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61183734
123cell communication involved in cardiac conduction (GO:0086065)2.57991884
124negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55174953
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54730365
126planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50106403
127negative regulation of catenin import into nucleus (GO:0035414)2.48094433
128positive regulation of dendrite development (GO:1900006)2.47999181
129potassium ion import (GO:0010107)2.47253743
130protein targeting to plasma membrane (GO:0072661)2.46045607
131neuromuscular synaptic transmission (GO:0007274)2.44810138
132cellular response to catecholamine stimulus (GO:0071870)2.43520712
133cellular response to monoamine stimulus (GO:0071868)2.43520712
134regulation of NFAT protein import into nucleus (GO:0051532)2.42342726
135acidic amino acid transport (GO:0015800)2.42183188
136regulation of ARF GTPase activity (GO:0032312)2.33826813
137regulation of early endosome to late endosome transport (GO:2000641)2.33773119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.83008301
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.75909110
3GBX2_23144817_ChIP-Seq_PC3_Human3.47776495
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19174458
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12880371
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03618608
7REST_21632747_ChIP-Seq_MESCs_Mouse2.85713372
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79060779
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79060779
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76184240
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.66365008
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63415189
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60537201
14DROSHA_22980978_ChIP-Seq_HELA_Human2.59933620
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59620327
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58813382
17LXR_22292898_ChIP-Seq_THP-1_Human2.56184842
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.54893510
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49543718
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.40654709
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37299685
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.37131398
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.32460045
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.26237431
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24193340
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20399619
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18815813
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11576808
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05640558
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05050548
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03519998
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02226417
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00828764
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91122684
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.85573882
36KDM2B_26808549_Chip-Seq_DND41_Human1.83114001
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82033279
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80457099
39AR_21572438_ChIP-Seq_LNCaP_Human1.78496081
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.68134171
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67297417
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62745656
43SMC4_20622854_ChIP-Seq_HELA_Human1.54576081
44SMAD4_21799915_ChIP-Seq_A2780_Human1.53476269
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50896935
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50388687
47TAF15_26573619_Chip-Seq_HEK293_Human1.49470005
48P68_20966046_ChIP-Seq_HELA_Human1.46123740
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.45776569
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45026570
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43452957
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43383885
53CREB1_26743006_Chip-Seq_LNCaP_Human1.43138246
54RACK7_27058665_Chip-Seq_MCF-7_Human1.42740165
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42340826
56* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41493695
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.41114879
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40769107
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.39990905
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39021978
61TCF7_22412390_ChIP-Seq_EML_Mouse1.37338083
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36894231
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36450735
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.35304616
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.34649375
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33931474
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33545394
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32985470
69ZNF274_21170338_ChIP-Seq_K562_Hela1.30174462
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29248689
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28350659
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27661521
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27614030
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26491067
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.25247430
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24780943
77CLOCK_20551151_ChIP-Seq_293T_Human1.23073988
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22160090
79P300_19829295_ChIP-Seq_ESCs_Human1.19984042
80AR_25329375_ChIP-Seq_VCAP_Human1.17951985
81AR_19668381_ChIP-Seq_PC3_Human1.17908129
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.17868137
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.17665210
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15939439
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15825902
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15792194
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14160563
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14132767
89STAT3_23295773_ChIP-Seq_U87_Human1.13689029
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13596229
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.13439183
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12767567
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12314858
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12157880
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11771902
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11741808
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11648967
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.11550052
99KDM2B_26808549_Chip-Seq_K562_Human1.10563222
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10461363
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.09871494
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09754657
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08997858
104VDR_21846776_ChIP-Seq_THP-1_Human1.08776120
105EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08737257
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08434587
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08055677
108OCT4_19829295_ChIP-Seq_ESCs_Human1.07974791
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07353032
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07103301
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06077358
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06069905
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04845981
114RNF2_27304074_Chip-Seq_NSC_Mouse1.04673042
115TP53_23651856_ChIP-Seq_MEFs_Mouse1.03966847
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03899560
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01023139
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00975665
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00619597
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.99507434
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.99428212
122TCF4_23295773_ChIP-Seq_U87_Human0.98981555
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98061268
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97986890
125ARNT_22903824_ChIP-Seq_MCF-7_Human0.97770300
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.97758210
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.96161854
128AHR_22903824_ChIP-Seq_MCF-7_Human0.94586197
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94351285
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94168937
131SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93108605
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.92304784
133GATA1_19941827_ChIP-Seq_MEL_Mouse0.92190234
134IGF1R_20145208_ChIP-Seq_DFB_Human0.92054716
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.91920589
136CTCF_27219007_Chip-Seq_Bcells_Human0.91271009
137SA1_27219007_Chip-Seq_Bcells_Human0.91245720
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90701384
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.89982709
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88984987
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88361280
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87138211
143OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86914563
144RUNX2_22187159_ChIP-Seq_PCA_Human0.86881052
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86622179
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84421928
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82772454
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82628348
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82091431
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.81924611
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81185828
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81185828
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80915439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.20558603
2MP0003880_abnormal_central_pattern4.68123380
3MP0003635_abnormal_synaptic_transmissio4.03804610
4MP0004270_analgesia3.73685447
5MP0009745_abnormal_behavioral_response3.32923640
6MP0002063_abnormal_learning/memory/cond3.22860331
7MP0009046_muscle_twitch3.20288117
8MP0002064_seizures3.17552190
9MP0001968_abnormal_touch/_nociception3.14585233
10MP0005423_abnormal_somatic_nervous2.82675309
11MP0002822_catalepsy2.74511766
12MP0002572_abnormal_emotion/affect_behav2.71119653
13MP0002734_abnormal_mechanical_nocicepti2.70497049
14MP0002272_abnormal_nervous_system2.68347073
15MP0002735_abnormal_chemical_nociception2.59666800
16MP0001486_abnormal_startle_reflex2.50379979
17MP0002736_abnormal_nociception_after2.47557203
18MP0001501_abnormal_sleep_pattern2.20221420
19MP0002733_abnormal_thermal_nociception2.15980529
20MP0004858_abnormal_nervous_system2.08083753
21MP0001970_abnormal_pain_threshold2.07859579
22MP0001440_abnormal_grooming_behavior2.03288109
23MP0002067_abnormal_sensory_capabilities2.02894892
24MP0003329_amyloid_beta_deposits2.02213813
25MP0008569_lethality_at_weaning1.98347382
26MP0001984_abnormal_olfaction1.95438131
27MP0002184_abnormal_innervation1.91106390
28MP0003705_abnormal_hypodermis_morpholog1.90979381
29MP0009780_abnormal_chondrocyte_physiolo1.86335255
30MP0002249_abnormal_larynx_morphology1.82015551
31MP0004811_abnormal_neuron_physiology1.81392750
32MP0006276_abnormal_autonomic_nervous1.79767299
33MP0000778_abnormal_nervous_system1.79248967
34MP0002557_abnormal_social/conspecific_i1.76827451
35MP0004924_abnormal_behavior1.70838772
36MP0005386_behavior/neurological_phenoty1.70838772
37MP0002909_abnormal_adrenal_gland1.70598756
38MP0005646_abnormal_pituitary_gland1.69829802
39MP0000955_abnormal_spinal_cord1.68108135
40MP0001348_abnormal_lacrimal_gland1.57625233
41MP0003787_abnormal_imprinting1.52908933
42MP0000747_muscle_weakness1.51688205
43MP0002882_abnormal_neuron_morphology1.50160127
44MP0003879_abnormal_hair_cell1.47853818
45MP0004885_abnormal_endolymph1.44310070
46MP0001529_abnormal_vocalization1.44245948
47MP0002066_abnormal_motor_capabilities/c1.43542855
48MP0004142_abnormal_muscle_tone1.40521309
49MP0001502_abnormal_circadian_rhythm1.37935440
50MP0003122_maternal_imprinting1.35018128
51MP0003172_abnormal_lysosome_physiology1.34838189
52MP0003633_abnormal_nervous_system1.33592951
53MP0003123_paternal_imprinting1.31072829
54MP0001905_abnormal_dopamine_level1.29954440
55MP0008438_abnormal_cutaneous_collagen1.29749759
56MP0000759_abnormal_skeletal_muscle1.27124256
57MP0000566_synostosis1.26903644
58MP0005645_abnormal_hypothalamus_physiol1.20772269
59MP0001958_emphysema1.19445409
60MP0005058_abnormal_lysosome_morphology1.17252262
61MP0003631_nervous_system_phenotype1.16246044
62MP0004087_abnormal_muscle_fiber1.14692789
63MP0005551_abnormal_eye_electrophysiolog1.14270391
64MP0000749_muscle_degeneration1.12172134
65MP0002229_neurodegeneration1.11999105
66MP0002089_abnormal_postnatal_growth/wei1.10071497
67MP0005451_abnormal_body_composition1.09423853
68MP0008260_abnormal_autophagy1.09176007
69MP0005394_taste/olfaction_phenotype1.08977504
70MP0005499_abnormal_olfactory_system1.08977504
71MP0005409_darkened_coat_color1.08888166
72MP0002152_abnormal_brain_morphology1.08048497
73MP0000751_myopathy1.06235867
74MP0001849_ear_inflammation1.05841525
75MP0004130_abnormal_muscle_cell1.04508264
76MP0003279_aneurysm0.99427707
77MP0003634_abnormal_glial_cell0.99270631
78MP0005257_abnormal_intraocular_pressure0.97616208
79MP0002106_abnormal_muscle_physiology0.96224181
80MP0005369_muscle_phenotype0.93864663
81MP0002108_abnormal_muscle_morphology0.93140399
82MP0000733_abnormal_muscle_development0.92936234
83MP0004742_abnormal_vestibular_system0.92882313
84MP0002069_abnormal_eating/drinking_beha0.92831731
85MP0003385_abnormal_body_wall0.92190147
86MP0002653_abnormal_ependyma_morphology0.91734031
87MP0002269_muscular_atrophy0.91585279
88MP0009384_cardiac_valve_regurgitation0.91430979
89MP0000920_abnormal_myelination0.90976248
90MP0008872_abnormal_physiological_respon0.90508224
91MP0001188_hyperpigmentation0.90309805
92MP0004233_abnormal_muscle_weight0.88622644
93MP0003632_abnormal_nervous_system0.88324599
94MP0000534_abnormal_ureter_morphology0.88259379
95MP0003283_abnormal_digestive_organ0.87591235
96MP0002752_abnormal_somatic_nervous0.87465041
97MP0000013_abnormal_adipose_tissue0.87261153
98MP0000604_amyloidosis0.87036127
99MP0010386_abnormal_urinary_bladder0.85578731
100MP0001177_atelectasis0.84474490
101MP0001963_abnormal_hearing_physiology0.83824077
102MP0003690_abnormal_glial_cell0.82949044
103MP0004036_abnormal_muscle_relaxation0.82358262
104MP0004145_abnormal_muscle_electrophysio0.82341027
105MP0008961_abnormal_basal_metabolism0.81705404
106MP0000569_abnormal_digit_pigmentation0.80978691
107MP0008874_decreased_physiological_sensi0.80612152
108MP0005503_abnormal_tendon_morphology0.80241095
109MP0003115_abnormal_respiratory_system0.80118203
110MP0002090_abnormal_vision0.79693241
111MP0000678_abnormal_parathyroid_gland0.77672718
112MP0004085_abnormal_heartbeat0.77664462
113MP0002638_abnormal_pupillary_reflex0.77607778
114MP0004510_myositis0.76722957
115MP0000003_abnormal_adipose_tissue0.76430886
116MP0000579_abnormal_nail_morphology0.75715669
117MP0003075_altered_response_to0.73992557
118MP0000750_abnormal_muscle_regeneration0.73888828
119MP0001346_abnormal_lacrimal_gland0.72932790
120MP0003942_abnormal_urinary_system0.72619211
121MP0009672_abnormal_birth_weight0.72362677
122MP0000631_abnormal_neuroendocrine_gland0.71261867
123MP0006072_abnormal_retinal_apoptosis0.71169428
124MP0001485_abnormal_pinna_reflex0.70734345
125MP0005535_abnormal_body_temperature0.68625870
126MP0004043_abnormal_pH_regulation0.67423719
127MP0005623_abnormal_meninges_morphology0.67144548
128MP0001299_abnormal_eye_distance/0.66552733
129MP0005171_absent_coat_pigmentation0.66192040
130MP0004215_abnormal_myocardial_fiber0.65604082
131MP0003137_abnormal_impulse_conducting0.63644984
132MP0001664_abnormal_digestion0.59082086
133MP0001986_abnormal_taste_sensitivity0.57985118
134MP0005253_abnormal_eye_physiology0.56745636
135MP0001943_abnormal_respiration0.55492152
136MP0003861_abnormal_nervous_system0.53904249
137MP0010769_abnormal_survival0.53433988
138MP0002876_abnormal_thyroid_physiology0.53209767
139MP0002837_dystrophic_cardiac_calcinosis0.52688247
140MP0002751_abnormal_autonomic_nervous0.52103529

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.07137070
2Myokymia (HP:0002411)6.95811459
3Focal seizures (HP:0007359)5.50150298
4Epileptic encephalopathy (HP:0200134)5.02922042
5Atonic seizures (HP:0010819)4.90049396
6Visual hallucinations (HP:0002367)4.82515382
7Febrile seizures (HP:0002373)4.47029411
8Progressive cerebellar ataxia (HP:0002073)4.22011105
9Action tremor (HP:0002345)4.10100317
10Absence seizures (HP:0002121)4.04724131
11Supranuclear gaze palsy (HP:0000605)3.73129867
12Obstructive sleep apnea (HP:0002870)3.72479735
13Dialeptic seizures (HP:0011146)3.68221285
14Ankle clonus (HP:0011448)3.63519202
15Generalized tonic-clonic seizures (HP:0002069)3.63482007
16Exercise-induced myalgia (HP:0003738)3.23325369
17Impaired vibration sensation in the lower limbs (HP:0002166)3.22648401
18Depression (HP:0000716)3.17924365
19Poor eye contact (HP:0000817)3.12297167
20Broad-based gait (HP:0002136)3.06689639
21Truncal ataxia (HP:0002078)3.05895818
22Gaze-evoked nystagmus (HP:0000640)3.05719026
23Abnormal eating behavior (HP:0100738)3.03260453
24Dysmetria (HP:0001310)2.99536093
25Dysdiadochokinesis (HP:0002075)2.97099021
26Peripheral hypomyelination (HP:0007182)2.93812023
27Abnormality of the lower motor neuron (HP:0002366)2.93552824
28Type 1 muscle fiber predominance (HP:0003803)2.93055019
29Urinary bladder sphincter dysfunction (HP:0002839)2.90549033
30Turricephaly (HP:0000262)2.88508695
31Protrusio acetabuli (HP:0003179)2.86801870
32Anxiety (HP:0000739)2.85559153
33Abnormal social behavior (HP:0012433)2.85554416
34Impaired social interactions (HP:0000735)2.85554416
35Shallow orbits (HP:0000586)2.85023311
36Amblyopia (HP:0000646)2.84827764
37Urinary urgency (HP:0000012)2.80949319
38Distal upper limb amyotrophy (HP:0007149)2.78936297
39Upper limb amyotrophy (HP:0009129)2.78936297
40Spastic gait (HP:0002064)2.78437912
41Pheochromocytoma (HP:0002666)2.77429282
42Mutism (HP:0002300)2.76694153
43Myopathic facies (HP:0002058)2.74590940
44Hyperventilation (HP:0002883)2.73077699
45Postural instability (HP:0002172)2.71346585
46Scanning speech (HP:0002168)2.69981451
47Abnormality of the corticospinal tract (HP:0002492)2.60327256
48Torticollis (HP:0000473)2.59059795
49Termporal pattern (HP:0011008)2.58233462
50Insidious onset (HP:0003587)2.58233462
51Hemiparesis (HP:0001269)2.56555165
52Neurofibrillary tangles (HP:0002185)2.56297514
53Hand muscle atrophy (HP:0009130)2.56013346
54Cerebral aneurysm (HP:0004944)2.52677119
55Genetic anticipation (HP:0003743)2.52139508
56Increased variability in muscle fiber diameter (HP:0003557)2.50523079
57Epileptiform EEG discharges (HP:0011182)2.49933627
58Limb dystonia (HP:0002451)2.49229878
59Hyperacusis (HP:0010780)2.47796768
60Lower limb amyotrophy (HP:0007210)2.46638397
61Abnormality of binocular vision (HP:0011514)2.46173707
62Diplopia (HP:0000651)2.46173707
63Intention tremor (HP:0002080)2.44953468
64Progressive inability to walk (HP:0002505)2.44412593
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.43828765
66Neuroendocrine neoplasm (HP:0100634)2.42805347
67EEG with generalized epileptiform discharges (HP:0011198)2.41615106
68Hemiplegia (HP:0002301)2.41135900
69Impaired smooth pursuit (HP:0007772)2.40623862
70Cerebral inclusion bodies (HP:0100314)2.38497937
71Focal dystonia (HP:0004373)2.37250888
72Ventricular fibrillation (HP:0001663)2.34652905
73Excessive salivation (HP:0003781)2.34207083
74Drooling (HP:0002307)2.34207083
75Lower limb muscle weakness (HP:0007340)2.33923702
76Hypsarrhythmia (HP:0002521)2.31972635
77Megalencephaly (HP:0001355)2.30245751
78Stridor (HP:0010307)2.28904955
79Bradykinesia (HP:0002067)2.28156820
80Polyphagia (HP:0002591)2.27625391
81Hammertoe (HP:0001765)2.26406350
82Fetal akinesia sequence (HP:0001989)2.23570694
83Failure to thrive in infancy (HP:0001531)2.19916173
84Bronchomalacia (HP:0002780)2.19762504
85Abnormality of skeletal muscle fiber size (HP:0012084)2.19327233
86Round ear (HP:0100830)2.18605623
87Papilledema (HP:0001085)2.17265643
88Sleep apnea (HP:0010535)2.16443693
89Abnormality of ocular smooth pursuit (HP:0000617)2.15309386
90Foot dorsiflexor weakness (HP:0009027)2.14712127
91Stereotypic behavior (HP:0000733)2.13232312
92Craniofacial dystonia (HP:0012179)2.11828779
93Distal lower limb amyotrophy (HP:0008944)2.11767830
94Mildly elevated creatine phosphokinase (HP:0008180)2.08850188
95Impaired vibratory sensation (HP:0002495)2.07704932
96Exercise-induced muscle cramps (HP:0003710)2.07065569
97Abnormality of the foot musculature (HP:0001436)2.05702146
98Annular pancreas (HP:0001734)2.02365733
99Status epilepticus (HP:0002133)2.01489561
100Insomnia (HP:0100785)2.01371397
101Agitation (HP:0000713)2.01207395
102Dysmetric saccades (HP:0000641)2.00534821
103Muscle fiber inclusion bodies (HP:0100299)1.99751246
104Abnormal gallbladder physiology (HP:0012438)1.99232242
105Cholecystitis (HP:0001082)1.99232242
106Hypoventilation (HP:0002791)1.99026878
107Akinesia (HP:0002304)1.98657547
108Pointed chin (HP:0000307)1.98621500
109Delusions (HP:0000746)1.97949580
110Aplasia involving bones of the extremities (HP:0009825)1.95435844
111Aplasia involving bones of the upper limbs (HP:0009823)1.95435844
112Aplasia of the phalanges of the hand (HP:0009802)1.95435844
113Absent speech (HP:0001344)1.94908420
114Specific learning disability (HP:0001328)1.94820561
115Gait ataxia (HP:0002066)1.94623922
116Rapidly progressive (HP:0003678)1.94378383
117Neuronal loss in central nervous system (HP:0002529)1.94158768
118Clonus (HP:0002169)1.92216034
119Thin ribs (HP:0000883)1.91101599
120Incomplete penetrance (HP:0003829)1.90920689
121Broad metatarsal (HP:0001783)1.89133005
122Gait imbalance (HP:0002141)1.89032162
123Blue irides (HP:0000635)1.88627657
124Inability to walk (HP:0002540)1.88100684
125Generalized myoclonic seizures (HP:0002123)1.86705441
126Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.85880372
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85491116
128Degeneration of the lateral corticospinal tracts (HP:0002314)1.85491116
129Increased connective tissue (HP:0009025)1.85379389
130Neoplasm of the peripheral nervous system (HP:0100007)1.83645566
131Premature rupture of membranes (HP:0001788)1.83470738
132Bowel incontinence (HP:0002607)1.83028218
133Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82848227
134Amyotrophic lateral sclerosis (HP:0007354)1.82660951
135Nemaline bodies (HP:0003798)1.80486235
136Tetraplegia (HP:0002445)1.80056114
137Rigidity (HP:0002063)1.79855299
138EMG: neuropathic changes (HP:0003445)1.79236895
139Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79110899
140Muscle stiffness (HP:0003552)1.79018370
141Ulnar bowing (HP:0003031)1.78677227
142Spinal rigidity (HP:0003306)1.78085554
143Alacrima (HP:0000522)1.77713567
144Psychosis (HP:0000709)1.77149962
145Ulnar deviation of the wrist (HP:0003049)1.76052041
146Abnormality of saccadic eye movements (HP:0000570)1.74338760
147Apathy (HP:0000741)1.73377398
148Difficulty running (HP:0009046)1.72968306
149Retinal dysplasia (HP:0007973)1.72236074
150Central scotoma (HP:0000603)1.72053369
151Spinal canal stenosis (HP:0003416)1.71998069
152Generalized hypotonia (HP:0001290)1.71938523
153Difficulty climbing stairs (HP:0003551)1.71868756
154Slow progression (HP:0003677)1.70620864
155Truncus arteriosus (HP:0001660)1.70463916
156Bladder diverticulum (HP:0000015)1.68972564
157Atelectasis (HP:0100750)1.68505151
158Distal sensory impairment (HP:0002936)1.68287959
159Mitral regurgitation (HP:0001653)1.67475351
160Achilles tendon contracture (HP:0001771)1.63780169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.30675019
2EPHA43.98426848
3MAP3K93.75963015
4MARK13.12188079
5TRIB32.92101109
6MAP3K42.90902042
7MINK12.86851762
8ICK2.56429196
9DAPK22.54709248
10PAK62.43031864
11MAP2K72.38624747
12CASK2.37668084
13NTRK22.21053853
14KSR22.03487412
15NTRK12.03406978
16CAMKK11.97216932
17PRKD31.95458065
18EEF2K1.81644124
19FGFR41.80224248
20MAP2K41.74999061
21MAP3K121.74186112
22PDGFRA1.57022294
23CDK191.56469380
24CDK51.56074800
25TTN1.54939109
26SIK11.52802316
27CAMKK21.48413784
28KSR11.45466689
29DAPK11.42464050
30PLK21.41324207
31ARAF1.40534173
32TNIK1.37755430
33PRPF4B1.37163104
34GRK51.36359970
35MAPK131.35063759
36TYRO31.29083610
37STK381.27884682
38UHMK11.27719690
39PRKCG1.25954687
40MAP3K71.23651952
41RIPK41.23141549
42MAP3K21.22226108
43PHKG11.20544553
44PHKG21.20544553
45MAP3K111.16818334
46LMTK21.15440011
47SGK4941.12417213
48SGK2231.12417213
49MAPK121.07925284
50SMG11.06816180
51CDK181.01694224
52DYRK1B0.99644746
53FGFR20.98772235
54CDK150.98504142
55CDK140.97588935
56FES0.97569312
57CAMK2A0.95966814
58PINK10.95887948
59SIK20.93707660
60OBSCN0.93066093
61EPHB10.92694328
62OXSR10.92530280
63PNCK0.92208209
64LATS20.91134725
65CDK120.90948641
66DDR20.88709184
67CAMK2B0.87786136
68PRKCH0.87447026
69CAMK10.87086686
70RET0.86529908
71CDK11A0.85933217
72MAP3K130.84062949
73TESK10.83171998
74PRKD20.81643243
75PAK30.80640711
76EPHA30.75465333
77SGK20.74958618
78STK110.71903935
79ERN10.71764492
80PTK2B0.70750236
81TAOK10.69732565
82PKN20.68118107
83DYRK1A0.67982383
84MARK20.66879017
85FGFR30.66510905
86MAP3K60.66120578
87WNK10.65826079
88ALK0.65565058
89CSNK1G20.64304049
90SGK30.62544759
91MTOR0.61982452
92NEK10.60458349
93CAMK2G0.59123791
94TNK20.58289905
95PTK20.57788980
96LIMK10.57193600
97PDPK10.56633359
98CCNB10.56622572
99PDK10.56155169
100MAP3K10.56106018
101PRKCE0.55744698
102NEK60.55511713
103SIK30.55253223
104SGK10.54386685
105CAMK2D0.54200165
106FER0.53600850
107RAF10.52143002
108CDC42BPA0.50604009
109MAP2K10.50090880
110PKN10.49953767
111PRKCZ0.48427579
112RIPK10.47395084
113CAMK40.47278084
114PRKAA10.47120184
115DAPK30.46941112
116RPS6KA30.46039337
117STK390.45698013
118BMPR20.45285249
119PRKD10.44618483
120BRSK10.42674180
121MAPK100.42600080
122MUSK0.42188035
123ROCK20.42031708
124FYN0.41894669
125MAPK80.41828823
126RPS6KA20.40325556
127BCR0.40091773
128CAMK1G0.40028819
129MAPK70.39710665
130BRAF0.39645009
131MAPK110.38815472
132MAPKAPK50.37613554

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.74261451
2Nicotine addiction_Homo sapiens_hsa050333.63941233
3Olfactory transduction_Homo sapiens_hsa047402.76298427
4GABAergic synapse_Homo sapiens_hsa047272.72743080
5Circadian entrainment_Homo sapiens_hsa047132.66236658
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62732338
7Glutamatergic synapse_Homo sapiens_hsa047242.47757787
8Long-term potentiation_Homo sapiens_hsa047202.44819567
9Morphine addiction_Homo sapiens_hsa050322.44791551
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36801894
11Amphetamine addiction_Homo sapiens_hsa050312.32087708
12Dopaminergic synapse_Homo sapiens_hsa047282.14359842
13Salivary secretion_Homo sapiens_hsa049702.09944042
14Insulin secretion_Homo sapiens_hsa049112.08902661
15Cholinergic synapse_Homo sapiens_hsa047251.93086916
16Collecting duct acid secretion_Homo sapiens_hsa049661.88972475
17Gastric acid secretion_Homo sapiens_hsa049711.83005632
18Taste transduction_Homo sapiens_hsa047421.74940725
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74511955
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73565496
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65343226
22Long-term depression_Homo sapiens_hsa047301.63833184
23Cocaine addiction_Homo sapiens_hsa050301.62837265
24Serotonergic synapse_Homo sapiens_hsa047261.59138300
25Oxytocin signaling pathway_Homo sapiens_hsa049211.56411991
26Renin secretion_Homo sapiens_hsa049241.51193224
27Calcium signaling pathway_Homo sapiens_hsa040201.47398470
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38265947
29GnRH signaling pathway_Homo sapiens_hsa049121.37612043
30Gap junction_Homo sapiens_hsa045401.35379051
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31161307
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31111543
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30018291
34Vibrio cholerae infection_Homo sapiens_hsa051101.29962910
35cAMP signaling pathway_Homo sapiens_hsa040241.18186188
36Type II diabetes mellitus_Homo sapiens_hsa049301.13109165
37Axon guidance_Homo sapiens_hsa043601.11798153
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11160686
39Estrogen signaling pathway_Homo sapiens_hsa049151.10790697
40Other glycan degradation_Homo sapiens_hsa005111.07146798
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05373863
42Glioma_Homo sapiens_hsa052141.04583936
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03489625
44Melanogenesis_Homo sapiens_hsa049161.00532893
45Cardiac muscle contraction_Homo sapiens_hsa042601.00518512
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98262535
47Notch signaling pathway_Homo sapiens_hsa043300.97933366
48ErbB signaling pathway_Homo sapiens_hsa040120.97053188
49Phototransduction_Homo sapiens_hsa047440.95386504
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94898270
51AMPK signaling pathway_Homo sapiens_hsa041520.93833818
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90860465
53Biosynthesis of amino acids_Homo sapiens_hsa012300.87222171
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.84954831
55Pancreatic secretion_Homo sapiens_hsa049720.83743731
56Oocyte meiosis_Homo sapiens_hsa041140.81786691
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.81640757
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79246042
59Dorso-ventral axis formation_Homo sapiens_hsa043200.78174653
60Thyroid hormone synthesis_Homo sapiens_hsa049180.77205199
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75374114
62Focal adhesion_Homo sapiens_hsa045100.74946350
63Arginine and proline metabolism_Homo sapiens_hsa003300.73650704
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.70112366
65Nitrogen metabolism_Homo sapiens_hsa009100.69467128
66ECM-receptor interaction_Homo sapiens_hsa045120.69339622
67Fructose and mannose metabolism_Homo sapiens_hsa000510.68502856
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68419514
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68336343
70MAPK signaling pathway_Homo sapiens_hsa040100.67312039
71Dilated cardiomyopathy_Homo sapiens_hsa054140.67100892
72Vitamin B6 metabolism_Homo sapiens_hsa007500.66422967
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.66270965
74Chronic myeloid leukemia_Homo sapiens_hsa052200.63760371
75Choline metabolism in cancer_Homo sapiens_hsa052310.63575132
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62244804
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62036366
78Arginine biosynthesis_Homo sapiens_hsa002200.61875606
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61044854
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59681571
81Circadian rhythm_Homo sapiens_hsa047100.56927128
82Glucagon signaling pathway_Homo sapiens_hsa049220.56239646
83Carbon metabolism_Homo sapiens_hsa012000.55648630
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54859106
85Alcoholism_Homo sapiens_hsa050340.54506570
86Endocytosis_Homo sapiens_hsa041440.53967886
87VEGF signaling pathway_Homo sapiens_hsa043700.53553036
88Ras signaling pathway_Homo sapiens_hsa040140.53504210
89Amoebiasis_Homo sapiens_hsa051460.53285228
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51629053
91Inositol phosphate metabolism_Homo sapiens_hsa005620.51193518
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50752266
93Rap1 signaling pathway_Homo sapiens_hsa040150.50154410
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.50064696
95Pentose phosphate pathway_Homo sapiens_hsa000300.48665565
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48531727
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48389867
98Bile secretion_Homo sapiens_hsa049760.48139786
99Type I diabetes mellitus_Homo sapiens_hsa049400.47975025
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.47309753
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47307598
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43908424
103mTOR signaling pathway_Homo sapiens_hsa041500.42887331
104Prion diseases_Homo sapiens_hsa050200.40759488
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39693615
106Endometrial cancer_Homo sapiens_hsa052130.39601824
107Renal cell carcinoma_Homo sapiens_hsa052110.39486989
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38853356
109Alzheimers disease_Homo sapiens_hsa050100.38573900
110Insulin signaling pathway_Homo sapiens_hsa049100.38335079
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37175163
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37048422
113Wnt signaling pathway_Homo sapiens_hsa043100.35766628
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35558496
115Non-small cell lung cancer_Homo sapiens_hsa052230.33271651
116Rheumatoid arthritis_Homo sapiens_hsa053230.33020511
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32799684
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31527969
119Ovarian steroidogenesis_Homo sapiens_hsa049130.30669856
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28559148
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.27882693
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.27419157
123Chemokine signaling pathway_Homo sapiens_hsa040620.27175197
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26182348

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