GGT8P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of digestive system process (GO:0060456)9.80664466
2negative regulation of heart rate (GO:0010459)9.47581785
3regulation of glucocorticoid secretion (GO:2000849)9.37543753
4positive regulation of steroid hormone secretion (GO:2000833)8.20043636
5regulation of corticosteroid hormone secretion (GO:2000846)7.72731737
6positive regulation of renal sodium excretion (GO:0035815)6.43811839
7regulation of action potential (GO:0098900)6.00066419
8positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.61959103
9ovulation cycle (GO:0042698)5.56942104
10negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.42076225
11negative regulation of heart contraction (GO:0045822)5.25148718
12regulation of steroid hormone secretion (GO:2000831)5.19970781
13L-glutamate transport (GO:0015813)4.88794584
14positive regulation of acute inflammatory response (GO:0002675)4.81785845
15regulation of phospholipase A2 activity (GO:0032429)4.77861618
16regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.68181065
17acidic amino acid transport (GO:0015800)4.50520684
18positive regulation of catecholamine secretion (GO:0033605)4.22322427
19regulation of renal sodium excretion (GO:0035813)4.11517915
20regulation of superoxide anion generation (GO:0032928)4.00487974
21regulation of vitamin D biosynthetic process (GO:0060556)3.82496122
22polyketide metabolic process (GO:0030638)3.80177854
23doxorubicin metabolic process (GO:0044598)3.80177854
24daunorubicin metabolic process (GO:0044597)3.80177854
25C4-dicarboxylate transport (GO:0015740)3.77408672
26regulation of podosome assembly (GO:0071801)3.66692909
27negative regulation of blood circulation (GO:1903523)3.63769969
28regulation of synaptic transmission, GABAergic (GO:0032228)3.59269529
29regulation of vitamin metabolic process (GO:0030656)3.51254514
30regulation of excretion (GO:0044062)3.46747085
31germinal center formation (GO:0002467)3.43087929
32early endosome to late endosome transport (GO:0045022)3.35423198
33aminoglycoside antibiotic metabolic process (GO:0030647)3.32490726
34cardiac left ventricle morphogenesis (GO:0003214)3.31177714
35long-term memory (GO:0007616)3.26242112
36regulation of memory T cell differentiation (GO:0043380)3.24924922
37positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.24366792
38negative regulation of meiosis (GO:0045835)3.19564948
39positive regulation of heat generation (GO:0031652)3.18200752
40regulation of digestive system process (GO:0044058)3.15875190
41tongue development (GO:0043586)3.11693089
42positive regulation of vesicle fusion (GO:0031340)3.10066524
43galactose catabolic process (GO:0019388)3.09905945
44regulation of endocrine process (GO:0044060)3.06820669
45peptide biosynthetic process (GO:0043043)3.06050021
46response to morphine (GO:0043278)3.01732944
47positive regulation of cell cycle checkpoint (GO:1901978)3.01396531
48regulation of mitotic spindle checkpoint (GO:1903504)3.01148076
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01148076
50microtubule nucleation (GO:0007020)2.97407479
51UDP-N-acetylglucosamine metabolic process (GO:0006047)2.93921162
52GTP biosynthetic process (GO:0006183)2.90124658
53response to phenylpropanoid (GO:0080184)2.88779994
54regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.87225195
55cellular modified amino acid catabolic process (GO:0042219)2.85592201
56response to pain (GO:0048265)2.85215258
57response to isoquinoline alkaloid (GO:0014072)2.84518722
58regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.84310438
59regulation of circadian sleep/wake cycle (GO:0042749)2.84310438
60protein insertion into membrane (GO:0051205)2.81568895
61response to peptidoglycan (GO:0032494)2.80783573
62positive regulation of osteoclast differentiation (GO:0045672)2.80366705
63regulation of T-helper 2 cell differentiation (GO:0045628)2.77150606
64negative regulation of membrane potential (GO:0045837)2.75880601
65regulation of feeding behavior (GO:0060259)2.75458315
66regulation of fever generation (GO:0031620)2.73148602
67neuronal action potential propagation (GO:0019227)2.71063424
68glucosamine-containing compound catabolic process (GO:1901072)2.66795222
69positive regulation of chemokine biosynthetic process (GO:0045080)2.64675852
70modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62545771
71positive regulation by organism of defense response of other organism involved in symbiotic interact2.62545771
72modulation by symbiont of host immune response (GO:0052553)2.62545771
73positive regulation by symbiont of host defense response (GO:0052509)2.62545771
74modulation by symbiont of host defense response (GO:0052031)2.62545771
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62545771
76positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.58996082
77negative regulation of neurological system process (GO:0031645)2.58799526
78nonribosomal peptide biosynthetic process (GO:0019184)2.58024126
79glutathione biosynthetic process (GO:0006750)2.57470806
80positive regulation of catenin import into nucleus (GO:0035413)2.57367896
81signal peptide processing (GO:0006465)2.57052927
82positive regulation of bone resorption (GO:0045780)2.53498360
83positive regulation of bone remodeling (GO:0046852)2.53498360
84regulation of interferon-beta biosynthetic process (GO:0045357)2.52469843
85positive regulation of circadian rhythm (GO:0042753)2.51245397
86regulation of prostaglandin secretion (GO:0032306)2.51139084
87UTP biosynthetic process (GO:0006228)2.50686116
88cellular extravasation (GO:0045123)2.48198835
89galactose metabolic process (GO:0006012)2.47624722
90post-embryonic morphogenesis (GO:0009886)2.47228241
91negative regulation of mast cell activation (GO:0033004)2.46180556
92response to manganese ion (GO:0010042)2.42574956
93protein prenylation (GO:0018342)2.41668164
94prenylation (GO:0097354)2.41668164
95embryonic placenta development (GO:0001892)2.36966775
96regulation of inositol phosphate biosynthetic process (GO:0010919)2.36901434
97cytokine secretion (GO:0050663)2.36559963
98positive regulation of action potential (GO:0045760)13.4798227
99tachykinin receptor signaling pathway (GO:0007217)12.8020416
100positive regulation of synaptic transmission, GABAergic (GO:0032230)11.5900834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.45390977
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.74115001
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.19954482
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.83934141
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.15294055
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.76673250
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.45531872
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.43570790
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39603986
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38714751
11FUS_26573619_Chip-Seq_HEK293_Human2.30550811
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26013032
13NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.24931712
14AHR_22903824_ChIP-Seq_MCF-7_Human2.17013147
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16497463
16GBX2_23144817_ChIP-Seq_PC3_Human2.11962736
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10468156
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09105726
19IGF1R_20145208_ChIP-Seq_DFB_Human2.07903278
20VDR_22108803_ChIP-Seq_LS180_Human2.05850825
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02598869
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97223125
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96088051
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95541980
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.89242299
26ER_23166858_ChIP-Seq_MCF-7_Human1.83532869
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.83137273
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80748248
29VDR_24787735_ChIP-Seq_THP-1_Human1.70786141
30* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69521167
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67945731
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66251482
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58258453
34TAL1_26923725_Chip-Seq_HPCs_Mouse1.57150384
35P300_19829295_ChIP-Seq_ESCs_Human1.56070970
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52273960
37CJUN_26792858_Chip-Seq_BT549_Human1.50381233
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48666764
39* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43625825
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.38285469
41* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32774557
42EGR1_19032775_ChIP-ChIP_M12_Human1.32439242
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.31033086
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31033086
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30541298
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26684029
47P300_18555785_Chip-Seq_ESCs_Mouse1.26136804
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25141013
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24325668
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.24031427
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22164134
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21380322
53GF1_26923725_Chip-Seq_HPCs_Mouse1.19806151
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19496020
55ELK1_19687146_ChIP-ChIP_HELA_Human1.17927684
56SOX2_18555785_Chip-Seq_ESCs_Mouse1.16931013
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16811510
58ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16653386
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.15486959
60AR_20517297_ChIP-Seq_VCAP_Human1.15189480
61CIITA_25753668_ChIP-Seq_RAJI_Human1.14963477
62TFEB_21752829_ChIP-Seq_HELA_Human1.14176040
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12542424
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11809393
65SMAD3_21741376_ChIP-Seq_HESCs_Human1.10286682
66CDX2_22108803_ChIP-Seq_LS180_Human1.09887754
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09318746
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09149705
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07747265
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07568122
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.06326132
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.05954035
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04871062
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.04789953
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.04465318
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03824345
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03824345
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03476076
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02691708
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02581905
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02010016
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02006190
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01421266
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01063484
85RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99429417
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99020958
87SMAD4_21799915_ChIP-Seq_A2780_Human0.98938139
88NMYC_18555785_Chip-Seq_ESCs_Mouse0.98452417
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.98307737
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97399707
91STAT3_18555785_Chip-Seq_ESCs_Mouse0.97181444
92STAT3_23295773_ChIP-Seq_U87_Human0.97046772
93ZFX_18555785_Chip-Seq_ESCs_Mouse0.96594769
94P53_22387025_ChIP-Seq_ESCs_Mouse0.96511073
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95895097
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95638509
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94582076
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94134803
99TAF15_26573619_Chip-Seq_HEK293_Human0.93779897
100STAT1_20625510_ChIP-Seq_HELA_Human0.93084487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder9.15509974
2MP0009379_abnormal_foot_pigmentation7.12615858
3MP0003879_abnormal_hair_cell2.99123325
4MP0000383_abnormal_hair_follicle2.98831667
5MP0001835_abnormal_antigen_presentation2.57318410
6MP0000579_abnormal_nail_morphology2.43139606
7MP0001853_heart_inflammation2.23446068
8MP0003806_abnormal_nucleotide_metabolis2.23414364
9MP0008995_early_reproductive_senescence2.15739050
10MP0002139_abnormal_hepatobiliary_system2.15621242
11MP0009785_altered_susceptibility_to2.11279395
12MP0005360_urolithiasis2.00249618
13MP0003880_abnormal_central_pattern1.99159884
14MP0003303_peritoneal_inflammation1.95922228
15MP0004947_skin_inflammation1.93249746
16MP0010678_abnormal_skin_adnexa1.88862401
17MP0003950_abnormal_plasma_membrane1.85884630
18MP0005423_abnormal_somatic_nervous1.81627246
19MP0005058_abnormal_lysosome_morphology1.79068526
20MP0001501_abnormal_sleep_pattern1.74518655
21MP0001986_abnormal_taste_sensitivity1.71895211
22MP0009053_abnormal_anal_canal1.65076064
23MP0002332_abnormal_exercise_endurance1.55939292
24MP0003436_decreased_susceptibility_to1.52262807
25MP0009764_decreased_sensitivity_to1.51838874
26MP0008775_abnormal_heart_ventricle1.50695623
27MP0000343_altered_response_to1.48961868
28MP0001756_abnormal_urination1.47082019
29MP0000538_abnormal_urinary_bladder1.45292988
30MP0009278_abnormal_bone_marrow1.42595457
31MP0002736_abnormal_nociception_after1.39778443
32MP0009384_cardiac_valve_regurgitation1.35276098
33MP0002148_abnormal_hypersensitivity_rea1.34938882
34MP0005671_abnormal_response_to1.34203551
35MP0005000_abnormal_immune_tolerance1.32120940
36MP0003075_altered_response_to1.30036918
37MP0003183_abnormal_peptide_metabolism1.29350680
38MP0000685_abnormal_immune_system1.27436363
39MP0001177_atelectasis1.27423665
40MP0006082_CNS_inflammation1.22140173
41MP0009765_abnormal_xenobiotic_induced1.22048563
42MP0008875_abnormal_xenobiotic_pharmacok1.18956645
43MP0001764_abnormal_homeostasis1.17485108
44MP0006072_abnormal_retinal_apoptosis1.15973103
45MP0002419_abnormal_innate_immunity1.15599799
46MP0002452_abnormal_antigen_presenting1.14777880
47MP0002006_tumorigenesis1.13782196
48MP0002723_abnormal_immune_serum1.10499220
49MP0001968_abnormal_touch/_nociception1.06035528
50MP0001970_abnormal_pain_threshold1.03439402
51MP0005332_abnormal_amino_acid0.98759392
52MP0001790_abnormal_immune_system0.98518548
53MP0005387_immune_system_phenotype0.98518548
54MP0004147_increased_porphyrin_level0.97759380
55MP0000858_altered_metastatic_potential0.96792381
56MP0001800_abnormal_humoral_immune0.96408562
57MP0008469_abnormal_protein_level0.95493401
58MP0003091_abnormal_cell_migration0.94665641
59MP0008877_abnormal_DNA_methylation0.92521595
60MP0002998_abnormal_bone_remodeling0.91728128
61MP0004782_abnormal_surfactant_physiolog0.89902019
62MP0000427_abnormal_hair_cycle0.87482126
63MP0004270_analgesia0.87379209
64MP0010155_abnormal_intestine_physiology0.87043778
65MP0001486_abnormal_startle_reflex0.85435530
66MP0005025_abnormal_response_to0.84579401
67MP0001849_ear_inflammation0.82207133
68MP0005166_decreased_susceptibility_to0.82003766
69MP0005670_abnormal_white_adipose0.81929899
70MP0000013_abnormal_adipose_tissue0.81292824
71MP0009763_increased_sensitivity_to0.79163640
72MP0000358_abnormal_cell_content/0.78804840
73MP0003656_abnormal_erythrocyte_physiolo0.77542182
74MP0001845_abnormal_inflammatory_respons0.77216474
75MP0002254_reproductive_system_inflammat0.75287568
76MP0003786_premature_aging0.74855184
77MP0001533_abnormal_skeleton_physiology0.74577179
78MP0000569_abnormal_digit_pigmentation0.74526306
79MP0009840_abnormal_foam_cell0.73354601
80MP0003300_gastrointestinal_ulcer0.73100170
81MP0003195_calcinosis0.72570159
82MP0005076_abnormal_cell_differentiation0.71963351
83MP0005197_abnormal_uvea_morphology0.71201097
84MP0001819_abnormal_immune_cell0.69034219
85MP0001881_abnormal_mammary_gland0.67967558
86MP0005085_abnormal_gallbladder_physiolo0.66770222
87MP0002420_abnormal_adaptive_immunity0.66096572
88MP0005666_abnormal_adipose_tissue0.66094597
89MP0000613_abnormal_salivary_gland0.63518448
90MP0009745_abnormal_behavioral_response0.63232501
91MP0003448_altered_tumor_morphology0.63019813
92MP0000647_abnormal_sebaceous_gland0.61241670
93MP0002098_abnormal_vibrissa_morphology0.59229415
94MP0000920_abnormal_myelination0.58040651
95MP0002405_respiratory_system_inflammati0.57822758
96MP0001216_abnormal_epidermal_layer0.55658473
97MP0000465_gastrointestinal_hemorrhage0.55039784
98MP0003453_abnormal_keratinocyte_physiol0.54258789
99MP0002735_abnormal_chemical_nociception0.54051598
100MP0002572_abnormal_emotion/affect_behav0.53738625

Predicted human phenotypes

RankGene SetZ-score
1Increased density of long bones (HP:0006392)7.50715589
2Thoracolumbar scoliosis (HP:0002944)4.79953408
3Hip dysplasia (HP:0001385)4.64253939
4Neoplasm of the heart (HP:0100544)4.59814317
5Alveolar cell carcinoma (HP:0006519)3.87041244
6Ependymoma (HP:0002888)3.70833060
7Spastic diplegia (HP:0001264)3.45192691
8Neoplasm of the tracheobronchial system (HP:0100552)3.33383659
9Agnosia (HP:0010524)3.25577963
10Hyperglycinuria (HP:0003108)3.24598244
11Enlarged epiphyses (HP:0010580)3.18918802
12Atonic seizures (HP:0010819)3.13899660
13Mediastinal lymphadenopathy (HP:0100721)3.11583848
14Abnormality of binocular vision (HP:0011514)3.09920737
15Diplopia (HP:0000651)3.09920737
16Hydroxyprolinuria (HP:0003080)3.09213962
17Abnormality of proline metabolism (HP:0010907)3.09213962
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.07365289
19Disinhibition (HP:0000734)3.03564515
20Retinal dysplasia (HP:0007973)2.95532181
21Prominent nose (HP:0000448)2.82645721
22Pendular nystagmus (HP:0012043)2.79023844
23Abnormality of the astrocytes (HP:0100707)2.73084777
24Astrocytoma (HP:0009592)2.73084777
25Long toe (HP:0010511)2.61456263
26Horizontal nystagmus (HP:0000666)2.53981124
27Abnormality of glycine metabolism (HP:0010895)2.52524607
28Abnormality of serine family amino acid metabolism (HP:0010894)2.52524607
29Hemiparesis (HP:0001269)2.51922682
30Broad face (HP:0000283)2.47534804
31Joint swelling (HP:0001386)2.46152814
32Vacuolated lymphocytes (HP:0001922)2.46114732
33Amyloidosis (HP:0011034)2.38647320
34Glioma (HP:0009733)2.35652162
35Radial bowing (HP:0002986)2.35420499
36Agitation (HP:0000713)2.34271490
37Femoral bowing (HP:0002980)2.31432244
38Difficulty climbing stairs (HP:0003551)2.30222037
39Pheochromocytoma (HP:0002666)2.29454014
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29127994
41Severe short stature (HP:0003510)2.25812081
42Inappropriate behavior (HP:0000719)2.25129838
43Loss of speech (HP:0002371)2.24827588
44Blepharitis (HP:0000498)2.22443017
45Elevated erythrocyte sedimentation rate (HP:0003565)2.22259166
46Apathy (HP:0000741)2.21150265
47Cranial hyperostosis (HP:0004437)2.20978646
48Pulmonary infiltrates (HP:0002113)2.17583124
49Conjugated hyperbilirubinemia (HP:0002908)2.15108566
50Growth hormone excess (HP:0000845)2.14547109
51Thick nail (HP:0001805)2.13659404
52Sensorimotor neuropathy (HP:0007141)2.09127013
53Fibular aplasia (HP:0002990)2.08152162
54Broad-based gait (HP:0002136)2.06941492
55Abnormality of macular pigmentation (HP:0008002)2.06647672
56Decreased muscle mass (HP:0003199)2.05895571
57Basal ganglia calcification (HP:0002135)2.05123634
58Increased cerebral lipofuscin (HP:0011813)2.03406491
59Dysostosis multiplex (HP:0000943)2.01817020
60Abnormality of glycolipid metabolism (HP:0010969)2.01455458
61Abnormality of liposaccharide metabolism (HP:0010968)2.01455458
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.01455458
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.00780910
64Hemoptysis (HP:0002105)1.98610871
65Hepatosplenomegaly (HP:0001433)1.98434626
66Polyneuropathy (HP:0001271)1.98257299
67Pelvic girdle muscle weakness (HP:0003749)1.97354335
68Erythema (HP:0010783)1.93641946
69Shoulder girdle muscle weakness (HP:0003547)1.92521055
70Gangrene (HP:0100758)1.91848943
71Diminished motivation (HP:0000745)1.91550215
72Absence seizures (HP:0002121)1.90513506
73Difficulty running (HP:0009046)1.88000278
74Abolished electroretinogram (ERG) (HP:0000550)1.87938433
75Dialeptic seizures (HP:0011146)1.86540116
76Hemiplegia (HP:0002301)1.84338432
77Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82941295
78Myocardial infarction (HP:0001658)1.82389654
79Hyperventilation (HP:0002883)1.82118806
80Poikiloderma (HP:0001029)1.80702579
81Abnormality of the 2nd finger (HP:0004100)1.79494337
82Constricted visual fields (HP:0001133)1.79149143
83Increased neuronal autofluorescent lipopigment (HP:0002074)1.79105603
84Abnormality of the pleura (HP:0002103)1.78913864
85Calf muscle hypertrophy (HP:0008981)1.78676833
86Prolonged neonatal jaundice (HP:0006579)1.77696511
87Pustule (HP:0200039)1.76009557
88Neuroendocrine neoplasm (HP:0100634)1.75569330
89Prominent supraorbital ridges (HP:0000336)1.73259513
90Recurrent bacterial skin infections (HP:0005406)1.71456113
91Restrictive lung disease (HP:0002091)1.71401954
92Renal cortical cysts (HP:0000803)1.70580468
93Ureteral stenosis (HP:0000071)1.68877921
94Erythroderma (HP:0001019)1.66715270
95Vasculitis (HP:0002633)1.65816944
96Abnormality of the nasal septum (HP:0000419)1.64600183
97Short tibia (HP:0005736)1.62884748
98Neuronal loss in central nervous system (HP:0002529)1.61495671
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60694279
100Spondylolisthesis (HP:0003302)1.58757629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB46.87027479
2IRAK36.39342639
3FLT32.88425528
4PKN12.72239773
5MAP3K142.69214003
6TAOK12.59917097
7MST1R2.59430114
8TLK12.37093200
9ZAK2.34239510
10PIK3CA2.33537801
11TTN2.17819036
12MAP4K11.96149455
13TBK11.90810804
14IKBKB1.85997012
15MET1.78857486
16MAPK111.73027029
17CDK81.72703877
18RPS6KA41.54290407
19MAP4K21.52072418
20TESK11.46290788
21CSF1R1.37939175
22MAP2K71.33929824
23ERBB21.31409830
24SIK31.27259312
25LIMK11.21252756
26BRD41.19291733
27MATK1.15274875
28PRKCE1.13011032
29CAMK2G1.11710401
30TTK1.09098153
31CHUK1.05830715
32NME21.05694757
33MAPKAPK31.04033957
34SRPK10.99724759
35TXK0.98628288
36TRPM70.96683632
37NTRK30.91587280
38NEK10.89528747
39FRK0.83395355
40IRAK10.82845260
41BMX0.79504436
42FGR0.74007311
43MARK10.71643707
44PKN20.69681635
45TAOK20.69509848
46ABL10.69195176
47PDGFRB0.69167327
48DDR20.66682329
49IKBKE0.65297402
50MAP3K90.63857642
51EPHA20.63368687
52RPS6KA20.62139013
53IRAK40.59602355
54PRKG20.59434600
55ADRBK20.57750456
56PBK0.54772944
57STK38L0.54624499
58CDC42BPA0.53831325
59EGFR0.51114787
60JAK10.50774476
61MAP3K40.50189543
62UHMK10.49549657
63STK240.47778095
64LATS20.47554248
65BMPR20.47261398
66BLK0.46944815
67BCR0.46623805
68STK40.45947343
69TRIM280.45161214
70ERBB30.45065250
71BUB10.44342433
72IRAK20.43493618
73CAMK2A0.42617012
74JAK20.42568826
75TAOK30.40938068
76JAK30.40491670
77KDR0.40207392
78MAPKAPK20.39297798
79MAP3K50.37136303
80RPS6KC10.36727251
81RPS6KL10.36727251
82ALK0.36072890
83PDGFRA0.35921383
84PRKD20.35619495
85CSNK1G20.35504262
86ABL20.35276837
87LCK0.34861124
88ROCK10.34760777
89PRKCZ0.34223898
90PRKCD0.34114119
91DAPK20.30508533
92PIK3CG0.30158846
93CAMK1D0.30059254
94PINK10.29407793
95GRK70.28250364
96MST40.28139868
97KIT0.28094009
98SYK0.27880915
99SIK10.27356233
100INSR0.27297402

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.29911078
2Graft-versus-host disease_Homo sapiens_hsa053324.28624930
3Allograft rejection_Homo sapiens_hsa053303.49141554
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.33187310
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.28710519
6Autoimmune thyroid disease_Homo sapiens_hsa053203.01038376
7Rheumatoid arthritis_Homo sapiens_hsa053232.96309308
8Antigen processing and presentation_Homo sapiens_hsa046122.86427100
9Type I diabetes mellitus_Homo sapiens_hsa049402.85705550
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61592761
11Collecting duct acid secretion_Homo sapiens_hsa049662.58296760
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11317412
13Leishmaniasis_Homo sapiens_hsa051402.02500720
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.00851947
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84436282
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76031690
17Staphylococcus aureus infection_Homo sapiens_hsa051501.72459815
18Viral myocarditis_Homo sapiens_hsa054161.72232720
19Other glycan degradation_Homo sapiens_hsa005111.67432206
20Tuberculosis_Homo sapiens_hsa051521.62832784
21Synaptic vesicle cycle_Homo sapiens_hsa047211.59816532
22Galactose metabolism_Homo sapiens_hsa000521.56476279
23Nicotine addiction_Homo sapiens_hsa050331.53840213
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49376706
25Starch and sucrose metabolism_Homo sapiens_hsa005001.39728922
26Influenza A_Homo sapiens_hsa051641.28028165
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.24792619
28Salmonella infection_Homo sapiens_hsa051321.24235055
29Dorso-ventral axis formation_Homo sapiens_hsa043201.19103234
30Toxoplasmosis_Homo sapiens_hsa051451.16707613
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.16343680
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16193464
33Fructose and mannose metabolism_Homo sapiens_hsa000511.13055922
34Legionellosis_Homo sapiens_hsa051341.09696690
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.07267027
36Bile secretion_Homo sapiens_hsa049761.03382801
37Phagosome_Homo sapiens_hsa041451.02657398
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99654666
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95564229
40African trypanosomiasis_Homo sapiens_hsa051430.94449893
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92436422
42Herpes simplex infection_Homo sapiens_hsa051680.92172071
43TNF signaling pathway_Homo sapiens_hsa046680.90853579
44Fatty acid biosynthesis_Homo sapiens_hsa000610.85928608
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85436152
46Osteoclast differentiation_Homo sapiens_hsa043800.85000019
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83718794
48Pertussis_Homo sapiens_hsa051330.83717998
49Sphingolipid metabolism_Homo sapiens_hsa006000.83330079
50Hematopoietic cell lineage_Homo sapiens_hsa046400.82652618
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82498868
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81356520
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.79777840
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79264498
55RNA polymerase_Homo sapiens_hsa030200.78465646
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.74510569
57Lysosome_Homo sapiens_hsa041420.67607148
58Shigellosis_Homo sapiens_hsa051310.65833395
59Proteasome_Homo sapiens_hsa030500.65778331
60Vibrio cholerae infection_Homo sapiens_hsa051100.65506340
61Ether lipid metabolism_Homo sapiens_hsa005650.65329614
62Epstein-Barr virus infection_Homo sapiens_hsa051690.56933663
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55087666
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50283950
65Malaria_Homo sapiens_hsa051440.48500758
66Mineral absorption_Homo sapiens_hsa049780.47639277
67One carbon pool by folate_Homo sapiens_hsa006700.45994815
68ABC transporters_Homo sapiens_hsa020100.45585018
69Histidine metabolism_Homo sapiens_hsa003400.41926310
70Tryptophan metabolism_Homo sapiens_hsa003800.41878290
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.40618873
72Sulfur relay system_Homo sapiens_hsa041220.39582608
73Folate biosynthesis_Homo sapiens_hsa007900.39400130
74Hepatitis C_Homo sapiens_hsa051600.38856164
75Taste transduction_Homo sapiens_hsa047420.38472400
76HIF-1 signaling pathway_Homo sapiens_hsa040660.36595104
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35201532
78Systemic lupus erythematosus_Homo sapiens_hsa053220.33540019
79PPAR signaling pathway_Homo sapiens_hsa033200.33260012
80Notch signaling pathway_Homo sapiens_hsa043300.32688801
81Protein export_Homo sapiens_hsa030600.29821420
82Glycerolipid metabolism_Homo sapiens_hsa005610.29298488
83Retinol metabolism_Homo sapiens_hsa008300.29250274
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28485160
85Choline metabolism in cancer_Homo sapiens_hsa052310.28409623
86Chemical carcinogenesis_Homo sapiens_hsa052040.27572020
87Pentose phosphate pathway_Homo sapiens_hsa000300.26200723
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26064672
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24355190
90Bladder cancer_Homo sapiens_hsa052190.23716492
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22938666
92Renin-angiotensin system_Homo sapiens_hsa046140.21860926
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20338025
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19960445
95Oxidative phosphorylation_Homo sapiens_hsa001900.19764147
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17590756
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16886261
98Nitrogen metabolism_Homo sapiens_hsa009100.16727391
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16363550
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15323370

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