GGTA1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.53950696
2positive regulation of mast cell activation (GO:0033005)4.45762818
3adenosine receptor signaling pathway (GO:0001973)4.26105153
4positive regulation of mast cell activation involved in immune response (GO:0033008)4.12035307
5positive regulation of mast cell degranulation (GO:0043306)4.12035307
6response to peptidoglycan (GO:0032494)4.01052357
7immunoglobulin mediated immune response (GO:0016064)3.90211173
8granulocyte activation (GO:0036230)3.89989947
9regulation of mast cell degranulation (GO:0043304)3.83762191
10cellular response to thyroid hormone stimulus (GO:0097067)3.83397324
11regulation of platelet activation (GO:0010543)3.80871822
12negative regulation of interleukin-12 production (GO:0032695)3.80146012
13neutrophil activation (GO:0042119)3.77301640
14positive regulation of gamma-delta T cell activation (GO:0046645)3.61647309
15negative regulation of erythrocyte differentiation (GO:0045647)3.61432514
16lipoxygenase pathway (GO:0019372)3.58885529
17regulation of mast cell activation involved in immune response (GO:0033006)3.56695832
18regulation of platelet aggregation (GO:0090330)3.50687754
19thrombin receptor signaling pathway (GO:0070493)3.49246447
20microglial cell activation (GO:0001774)3.42406399
21positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.36412097
22macrophage activation involved in immune response (GO:0002281)3.34846151
23regulation of mast cell activation (GO:0033003)3.34602336
24myeloid cell activation involved in immune response (GO:0002275)3.27354655
25regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26278109
26positive regulation of leukocyte degranulation (GO:0043302)3.25762456
27regulation of leukocyte degranulation (GO:0043300)3.21166281
28B cell mediated immunity (GO:0019724)3.20382363
29glycosphingolipid catabolic process (GO:0046479)3.17484339
30angiogenesis involved in wound healing (GO:0060055)3.17186743
31positive regulation of cellular amide metabolic process (GO:0034250)3.15612414
32positive regulation by symbiont of host defense response (GO:0052509)3.13427182
33modulation by symbiont of host defense response (GO:0052031)3.13427182
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13427182
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13427182
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.13427182
37modulation by symbiont of host immune response (GO:0052553)3.13427182
38regulation of T-helper 1 cell differentiation (GO:0045625)3.11511680
39phagocytosis, engulfment (GO:0006911)3.06617210
40G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.05778233
41regulation of MHC class II biosynthetic process (GO:0045346)3.05453093
42negative regulation of platelet activation (GO:0010544)3.00251653
43negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.97457083
44positive regulation of B cell differentiation (GO:0045579)2.95549646
45lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91766962
46macrophage activation (GO:0042116)2.87860257
47regulation of T-helper 2 cell differentiation (GO:0045628)2.87677316
48detection of other organism (GO:0098543)2.86542631
49regulation of hypersensitivity (GO:0002883)2.85403887
50glycolipid catabolic process (GO:0019377)2.83357993
51regulation of mononuclear cell migration (GO:0071675)2.80745861
52positive regulation of type 2 immune response (GO:0002830)2.80541717
53purinergic receptor signaling pathway (GO:0035587)2.79375869
54positive regulation of antigen processing and presentation (GO:0002579)2.78687918
55negative regulation of nitric oxide biosynthetic process (GO:0045019)2.78256131
56response to thyroid hormone (GO:0097066)2.77376367
57negative regulation of homotypic cell-cell adhesion (GO:0034111)2.76607699
58leukocyte migration involved in inflammatory response (GO:0002523)2.76202832
59interferon-gamma-mediated signaling pathway (GO:0060333)2.75270007
60cyclooxygenase pathway (GO:0019371)2.75056534
61G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.74035176
62cellular extravasation (GO:0045123)2.74002787
63low-density lipoprotein particle remodeling (GO:0034374)2.73092083
64detection of bacterium (GO:0016045)2.72162099
65amino sugar catabolic process (GO:0046348)2.70289209
66detection of molecule of bacterial origin (GO:0032490)2.68194922
67regulation of antigen processing and presentation (GO:0002577)2.67409653
68leukocyte degranulation (GO:0043299)2.66500337
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.66055967
70positive regulation of macrophage differentiation (GO:0045651)2.64938649
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64711179
72germinal center formation (GO:0002467)2.64139931
73negative regulation of cytokine production involved in immune response (GO:0002719)2.63739816
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63715453
75positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.63210527
76positive regulation of immunoglobulin mediated immune response (GO:0002891)2.61922624
77positive regulation of B cell mediated immunity (GO:0002714)2.61922624
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61462963
79negative regulation of cell killing (GO:0031342)2.61462963
80detection of external biotic stimulus (GO:0098581)2.60427660
81negative regulation of interleukin-17 production (GO:0032700)2.60389309
82T-helper 1 type immune response (GO:0042088)2.59530086
83positive regulation of monocyte chemotaxis (GO:0090026)2.59136199
84membrane invagination (GO:0010324)2.58920349
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58873179
86superoxide anion generation (GO:0042554)2.58741464
87platelet aggregation (GO:0070527)2.57054325
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.56815226
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.56686068
90response to host immune response (GO:0052572)2.56686068
91pinocytosis (GO:0006907)2.55898687
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55619817
93regulation of inflammatory response to antigenic stimulus (GO:0002861)2.55518191
94regulation of macrophage derived foam cell differentiation (GO:0010743)2.54310094
95ceramide catabolic process (GO:0046514)2.54234680
96purinergic nucleotide receptor signaling pathway (GO:0035590)2.52940050
97negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.52468203
98positive regulation of tumor necrosis factor production (GO:0032760)2.51966199
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51657312
100positive regulation of systemic arterial blood pressure (GO:0003084)2.51285780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.49781497
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.25844750
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.88226121
4SCL_19346495_ChIP-Seq_HPC-7_Human3.57980020
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37902568
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.35161054
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14661461
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.02594317
9RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89392234
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88928433
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.88355476
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84837859
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.82844158
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74039090
15SPI1_23127762_ChIP-Seq_K562_Human2.50041245
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50034057
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33270617
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.31528270
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29770327
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24793392
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14869290
22GATA1_19941827_ChIP-Seq_MEL_Mouse2.10879762
23GATA1_19941826_ChIP-Seq_K562_Human2.07682711
24VDR_24763502_ChIP-Seq_THP-1_Human2.03573426
25GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.96036547
26MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93036711
27GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.92536451
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87461458
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.86750862
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.86737714
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83963778
32SPI1_23547873_ChIP-Seq_NB4_Human1.83190495
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80283792
34VDR_24787735_ChIP-Seq_THP-1_Human1.77680179
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.74874422
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72409575
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70993732
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70413286
39RUNX_20019798_ChIP-Seq_JUKART_Human1.68911763
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61629929
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60512341
42GATA2_19941826_ChIP-Seq_K562_Human1.57457530
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57270284
44VDR_21846776_ChIP-Seq_THP-1_Human1.56785485
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55864623
46GATA1_22025678_ChIP-Seq_K562_Human1.51010362
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40421663
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40133831
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37867247
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30459291
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29243760
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26040148
53PU_27001747_Chip-Seq_BMDM_Mouse1.26017186
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24118388
55MYB_26560356_Chip-Seq_TH2_Human1.22962095
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22004841
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21629332
58STAT1_20625510_ChIP-Seq_HELA_Human1.20915270
59LXR_22292898_ChIP-Seq_THP-1_Human1.19921611
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18807011
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17315124
62GATA1_19941827_ChIP-Seq_MEL86_Mouse1.16501059
63UTX_26944678_Chip-Seq_JUKART_Human1.16362936
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15981530
65MAF_26560356_Chip-Seq_TH1_Human1.15007121
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14575069
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12386396
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11818460
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09889146
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08451046
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.08138242
72TCF7_22412390_ChIP-Seq_EML_Mouse1.07211638
73SPI1_20517297_ChIP-Seq_HL60_Human1.04697146
74BCL6_27268052_Chip-Seq_Bcells_Human1.01456414
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01380460
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98866606
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98670931
78RXR_22158963_ChIP-Seq_LIVER_Mouse0.95342011
79GATA3_27048872_Chip-Seq_THYMUS_Human0.94648174
80BCOR_27268052_Chip-Seq_Bcells_Human0.92396885
81NCOR1_26117541_ChIP-Seq_K562_Human0.89200390
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87366932
83KDM2B_26808549_Chip-Seq_DND41_Human0.85951780
84CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85789946
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.85351864
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85317187
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.84263209
88MYB_26560356_Chip-Seq_TH1_Human0.83972780
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83820607
90LXR_22158963_ChIP-Seq_LIVER_Mouse0.81754431
91GATA3_26560356_Chip-Seq_TH2_Human0.81749859
92EGR1_19374776_ChIP-ChIP_THP-1_Human0.81035713
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79850997
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78155827
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78020438
96ELK4_26923725_Chip-Seq_MESODERM_Mouse0.77420024
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77309088
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77134739
99KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75775344
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75241303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.84126675
2MP0003303_peritoneal_inflammation4.52315824
3MP0003724_increased_susceptibility_to3.93289573
4MP0005058_abnormal_lysosome_morphology3.83588150
5MP0008004_abnormal_stomach_pH3.49133418
6MP0002148_abnormal_hypersensitivity_rea3.07468195
7MP0001835_abnormal_antigen_presentation3.04376034
8MP0003436_decreased_susceptibility_to2.84147692
9MP0004510_myositis2.82418438
10MP0006082_CNS_inflammation2.75512899
11MP0005671_abnormal_response_to2.57910494
12MP0000343_altered_response_to2.55662836
13MP0002419_abnormal_innate_immunity2.47041010
14MP0005000_abnormal_immune_tolerance2.40115272
15MP0003300_gastrointestinal_ulcer2.27143685
16MP0009785_altered_susceptibility_to2.25920828
17MP0005025_abnormal_response_to2.23372317
18MP0001790_abnormal_immune_system2.18238630
19MP0005387_immune_system_phenotype2.18238630
20MP0003075_altered_response_to2.17258468
21MP0000465_gastrointestinal_hemorrhage2.12814535
22MP0003172_abnormal_lysosome_physiology2.06973543
23MP0005167_abnormal_blood-brain_barrier2.04843172
24MP0009764_decreased_sensitivity_to2.00610841
25MP0001533_abnormal_skeleton_physiology1.99612686
26MP0002452_abnormal_antigen_presenting1.99394759
27MP0002723_abnormal_immune_serum1.95167091
28MP0001545_abnormal_hematopoietic_system1.94103511
29MP0005397_hematopoietic_system_phenotyp1.94103511
30MP0001800_abnormal_humoral_immune1.86959373
31MP0009840_abnormal_foam_cell1.80433605
32MP0009278_abnormal_bone_marrow1.77799103
33MP0010155_abnormal_intestine_physiology1.73902607
34MP0002420_abnormal_adaptive_immunity1.68676721
35MP0001819_abnormal_immune_cell1.68098520
36MP0003828_pulmonary_edema1.62762134
37MP0001845_abnormal_inflammatory_respons1.58684001
38MP0002998_abnormal_bone_remodeling1.57502227
39MP0000685_abnormal_immune_system1.57409780
40MP0004947_skin_inflammation1.55591414
41MP0003690_abnormal_glial_cell1.37459129
42MP0003191_abnormal_cellular_cholesterol1.34774334
43MP0000858_altered_metastatic_potential1.31256292
44MP0002405_respiratory_system_inflammati1.31081767
45MP0008469_abnormal_protein_level1.29066273
46MP0001851_eye_inflammation1.26458165
47MP0002398_abnormal_bone_marrow1.26379928
48MP0002139_abnormal_hepatobiliary_system1.26158934
49MP0000604_amyloidosis1.25841973
50MP0005165_increased_susceptibility_to1.24542585
51MP0000716_abnormal_immune_system1.23405561
52MP0005166_decreased_susceptibility_to1.22521764
53MP0003448_altered_tumor_morphology1.21033496
54MP0006054_spinal_hemorrhage1.15239680
55MP0003806_abnormal_nucleotide_metabolis1.14551655
56MP0009763_increased_sensitivity_to1.13497009
57MP0001663_abnormal_digestive_system1.11454050
58MP0009333_abnormal_splenocyte_physiolog1.08596695
59MP0001853_heart_inflammation1.08154332
60MP0003453_abnormal_keratinocyte_physiol1.07840461
61MP0000249_abnormal_blood_vessel1.07085947
62MP0005310_abnormal_salivary_gland1.06644540
63MP0000689_abnormal_spleen_morphology1.06121232
64MP0002429_abnormal_blood_cell1.06115072
65MP0003183_abnormal_peptide_metabolism1.05654354
66MP0003656_abnormal_erythrocyte_physiolo0.99113639
67MP0004130_abnormal_muscle_cell0.97534932
68MP0000230_abnormal_systemic_arterial0.94847224
69MP0003879_abnormal_hair_cell0.93848648
70MP0008874_decreased_physiological_sensi0.93577835
71MP0005666_abnormal_adipose_tissue0.92318836
72MP0002722_abnormal_immune_system0.91510318
73MP0005365_abnormal_bile_salt0.89564834
74MP0005535_abnormal_body_temperature0.88771733
75MP0002332_abnormal_exercise_endurance0.88680316
76MP0000920_abnormal_myelination0.86627759
77MP0003638_abnormal_response/metabolism_0.84819519
78MP0005390_skeleton_phenotype0.82269660
79MP0009765_abnormal_xenobiotic_induced0.81869918
80MP0005647_abnormal_sex_gland0.78914029
81MP0005164_abnormal_response_to0.76639957
82MP0008260_abnormal_autophagy0.76619943
83MP0005451_abnormal_body_composition0.75761851
84MP0003866_abnormal_defecation0.75655138
85MP0004883_abnormal_blood_vessel0.74124648
86MP0005083_abnormal_biliary_tract0.73605632
87MP0003795_abnormal_bone_structure0.71230528
88MP0004084_abnormal_cardiac_muscle0.68903365
89MP0005410_abnormal_fertilization0.68820849
90MP0003186_abnormal_redox_activity0.67208088
91MP0005670_abnormal_white_adipose0.66007775
92MP0005584_abnormal_enzyme/coenzyme_acti0.65823136
93MP0002118_abnormal_lipid_homeostasis0.65586729
94MP0005023_abnormal_wound_healing0.65051303
95MP0005381_digestive/alimentary_phenotyp0.64859896
96MP0001542_abnormal_bone_strength0.64551237
97MP0003763_abnormal_thymus_physiology0.62170324
98MP0002132_abnormal_respiratory_system0.59059880
99MP0003566_abnormal_cell_adhesion0.58135170
100MP0004036_abnormal_muscle_relaxation0.57619673

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.51720026
2Purpura (HP:0000979)6.41459344
3Petechiae (HP:0000967)6.24624541
4Abnormality of liposaccharide metabolism (HP:0010968)5.06513131
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.06513131
6Abnormality of glycolipid metabolism (HP:0010969)5.06513131
7Systemic lupus erythematosus (HP:0002725)5.01643284
8Epistaxis (HP:0000421)4.95940720
9Menorrhagia (HP:0000132)4.94827057
10Increased mean platelet volume (HP:0011877)4.94765770
11Abnormal platelet volume (HP:0011876)4.88053424
12Spontaneous hematomas (HP:0007420)4.57796383
13Abnormality of macrophages (HP:0004311)4.45779471
14Vacuolated lymphocytes (HP:0001922)4.34593325
15Dysostosis multiplex (HP:0000943)4.33746578
16Increased cerebral lipofuscin (HP:0011813)4.18436903
17Gingival bleeding (HP:0000225)4.03866315
18Recurrent bacterial skin infections (HP:0005406)3.77789806
19Recurrent abscess formation (HP:0002722)3.69013854
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.61870596
21Eczematoid dermatitis (HP:0000976)3.53792195
22Abnormality of the vasculature of the conjunctiva (HP:0008054)3.50506861
23Stomatitis (HP:0010280)3.49422205
24Disinhibition (HP:0000734)3.44926043
25Mutism (HP:0002300)3.29709589
26Loss of speech (HP:0002371)3.27450710
27Abnormal platelet function (HP:0011869)3.23104648
28Impaired platelet aggregation (HP:0003540)3.23104648
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.23088641
30Obstructive lung disease (HP:0006536)3.13834400
31Chronic obstructive pulmonary disease (HP:0006510)3.13834400
32Glomerulonephritis (HP:0000099)3.06771082
33Hepatosplenomegaly (HP:0001433)3.06212984
34Myositis (HP:0100614)2.95741849
35Conjunctival telangiectasia (HP:0000524)2.94687211
36Orchitis (HP:0100796)2.90238545
37Hyperlipoproteinemia (HP:0010980)2.80068359
38Axonal loss (HP:0003447)2.79711847
39Optic neuritis (HP:0100653)2.76315884
40Retrobulbar optic neuritis (HP:0100654)2.76315884
41Autoimmune thrombocytopenia (HP:0001973)2.73917838
42Recurrent gram-negative bacterial infections (HP:0005420)2.68717376
43Complement deficiency (HP:0004431)2.62518224
44Abnormality of lateral ventricle (HP:0030047)2.58417647
45Increased serum ferritin (HP:0003281)2.58012236
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57263628
47Abnormality of polysaccharide metabolism (HP:0011012)2.57263628
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57263628
49Abnormality of iron homeostasis (HP:0011031)2.46527850
50Amyloidosis (HP:0011034)2.46470245
51Mediastinal lymphadenopathy (HP:0100721)2.45979814
52Urinary glycosaminoglycan excretion (HP:0003541)2.44360072
53Mucopolysacchariduria (HP:0008155)2.44360072
54Basal ganglia calcification (HP:0002135)2.44021518
55Elevated erythrocyte sedimentation rate (HP:0003565)2.41223499
56Increased IgM level (HP:0003496)2.33771180
57Encephalitis (HP:0002383)2.29922001
58Myocardial infarction (HP:0001658)2.25854996
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25312860
60Recurrent skin infections (HP:0001581)2.19372582
61Vertigo (HP:0002321)2.19269844
62Nausea (HP:0002018)2.18694587
63Meningitis (HP:0001287)2.16413396
64Nuclear cataract (HP:0100018)2.14826923
65Vasculitis (HP:0002633)2.13711561
66Bruising susceptibility (HP:0000978)2.10907952
67Abnormality of complement system (HP:0005339)2.10625944
68Arterial thrombosis (HP:0004420)2.09319994
69Pulmonary infiltrates (HP:0002113)2.08604784
70Hematochezia (HP:0002573)2.06074183
71Recurrent fungal infections (HP:0002841)2.05205503
72Pulmonary embolism (HP:0002204)2.03718953
73Neurofibrillary tangles (HP:0002185)2.03454648
74Abnormality of transition element cation homeostasis (HP:0011030)2.03226795
75Paralysis (HP:0003470)2.02642310
76Hemoptysis (HP:0002105)2.02594641
77Keratoconjunctivitis sicca (HP:0001097)2.01084170
78Abnormality of the common coagulation pathway (HP:0010990)2.00340580
79Joint hemorrhage (HP:0005261)1.98884272
80Episodic fever (HP:0001954)1.97884459
81Polyneuropathy (HP:0001271)1.96240233
82Gingivitis (HP:0000230)1.94048383
83Chest pain (HP:0100749)1.93699246
84Joint swelling (HP:0001386)1.93489996
85Progressive neurologic deterioration (HP:0002344)1.90885916
86Agnosia (HP:0010524)1.90832263
87Gangrene (HP:0100758)1.89651496
88Neuronal loss in central nervous system (HP:0002529)1.88705102
89Thrombocytosis (HP:0001894)1.87539138
90Abnormality of the prostate (HP:0008775)1.87374077
91Leukocytosis (HP:0001974)1.86461069
92Urticaria (HP:0001025)1.83819896
93Mucosal telangiectasiae (HP:0100579)1.81638239
94Cerebral inclusion bodies (HP:0100314)1.80832960
95Ventricular fibrillation (HP:0001663)1.80705038
96Apathy (HP:0000741)1.80454521
97Diminished motivation (HP:0000745)1.80259375
98Nephritis (HP:0000123)1.80169275
99Keratoconjunctivitis (HP:0001096)1.79666063
100Hypergammaglobulinemia (HP:0010702)1.78418465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.54429151
2BLK3.33814519
3CSF1R2.32606436
4IRAK32.32516421
5PIM22.23687952
6MAP2K32.18514384
7BMX2.15715681
8SYK2.11501184
9TAOK22.10974153
10TEC2.06655993
11BTK2.06232280
12MAP3K112.04547637
13GRK71.95467531
14ZAP701.92305560
15FES1.88908184
16FGR1.88879353
17MAP4K11.85659118
18BMPR21.84077312
19MAP3K141.82632775
20TAOK31.80450755
21TBK11.78829418
22IKBKB1.74200166
23MAP3K31.69080656
24TGFBR21.68964360
25MATK1.68929004
26CSK1.68136532
27TAOK11.62030525
28TYK21.60643700
29NME21.58588040
30TNK21.57228408
31ARAF1.54606002
32MYLK1.51079213
33ERN11.50462014
34LYN1.45054187
35TXK1.44231228
36DDR21.38530213
37JAK31.35010246
38IRAK41.32993334
39ADRBK21.27890884
40TESK21.27304275
41HCK1.26309575
42ACVR1B1.06756803
43GRK51.06469842
44GRK61.06278088
45ABL21.06139920
46MAP3K51.06070376
47PIK3CG1.05961109
48IKBKE1.03985186
49MAP3K11.01672466
50MST41.01500163
51KIT1.00185713
52CAMKK20.99211116
53PRPF4B0.98927354
54PTK2B0.96913271
55JAK20.95527237
56EIF2AK10.92877938
57LCK0.90905357
58DAPK20.90587437
59RIPK10.89383423
60DAPK30.86446380
61CDC42BPA0.85192997
62ITK0.83707643
63JAK10.80817350
64MOS0.80136694
65IRAK10.79437984
66PKN10.77000501
67MARK30.75180359
68MAPK120.71560079
69MAP3K130.70563222
70PDK10.69274512
71PDPK10.64165739
72IRAK20.62818351
73MAPKAPK30.61348874
74PAK10.56324572
75ILK0.55485451
76PRKD10.52896439
77MAPK40.51160080
78PIM10.49839143
79FYN0.47283039
80SIK30.44396180
81EPHA30.41216088
82PRKACG0.39965500
83KDR0.39154132
84ABL10.37234090
85PRKCD0.37156019
86MAP2K60.36198700
87ADRBK10.35342975
88DMPK0.35096935
89TESK10.34985198
90PRKCQ0.34554492
91STK240.33007682
92MAPK70.32648469
93DYRK1B0.32243612
94EPHB20.31564416
95RET0.31335005
96RPS6KL10.30295727
97RPS6KC10.30295727
98HIPK20.30233249
99CDK60.28689026
100BCKDK0.27746402

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.44790189
2Asthma_Homo sapiens_hsa053103.23411843
3Allograft rejection_Homo sapiens_hsa053302.70816047
4Other glycan degradation_Homo sapiens_hsa005112.54836014
5Lysosome_Homo sapiens_hsa041422.45629805
6Leishmaniasis_Homo sapiens_hsa051402.45377416
7Osteoclast differentiation_Homo sapiens_hsa043802.41206198
8Platelet activation_Homo sapiens_hsa046112.39648691
9Graft-versus-host disease_Homo sapiens_hsa053322.38341862
10Autoimmune thyroid disease_Homo sapiens_hsa053202.32235888
11Hematopoietic cell lineage_Homo sapiens_hsa046402.23612896
12Rheumatoid arthritis_Homo sapiens_hsa053232.22916503
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.19155154
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07073625
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.97351227
16Tuberculosis_Homo sapiens_hsa051521.93202839
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92263673
18Malaria_Homo sapiens_hsa051441.88063700
19Type I diabetes mellitus_Homo sapiens_hsa049401.78272696
20Phagosome_Homo sapiens_hsa041451.73140557
21Pertussis_Homo sapiens_hsa051331.65736671
22Antigen processing and presentation_Homo sapiens_hsa046121.49187972
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.48409511
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46315702
25Chemokine signaling pathway_Homo sapiens_hsa040621.44764239
26Toxoplasmosis_Homo sapiens_hsa051451.39900391
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39475618
28B cell receptor signaling pathway_Homo sapiens_hsa046621.38652982
29Viral myocarditis_Homo sapiens_hsa054161.34696957
30Salmonella infection_Homo sapiens_hsa051321.24372027
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22903474
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19707841
33Legionellosis_Homo sapiens_hsa051341.19562482
34Collecting duct acid secretion_Homo sapiens_hsa049661.15420815
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14429043
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13327347
37TNF signaling pathway_Homo sapiens_hsa046681.12441490
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10967088
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10642184
40Influenza A_Homo sapiens_hsa051641.05690699
41Complement and coagulation cascades_Homo sapiens_hsa046101.03253608
42Shigellosis_Homo sapiens_hsa051311.02223531
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01823738
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01621424
45Arachidonic acid metabolism_Homo sapiens_hsa005900.97455907
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96636015
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95910608
48Primary immunodeficiency_Homo sapiens_hsa053400.91909650
49African trypanosomiasis_Homo sapiens_hsa051430.90348192
50Systemic lupus erythematosus_Homo sapiens_hsa053220.88214155
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86908461
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84852483
53Amoebiasis_Homo sapiens_hsa051460.84290681
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83438556
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82430301
56Herpes simplex infection_Homo sapiens_hsa051680.78923501
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.77151875
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74554014
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73671710
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.73287391
61T cell receptor signaling pathway_Homo sapiens_hsa046600.72968783
62Endocytosis_Homo sapiens_hsa041440.72560969
63Prion diseases_Homo sapiens_hsa050200.68692654
64Renin-angiotensin system_Homo sapiens_hsa046140.67742050
65Measles_Homo sapiens_hsa051620.66959435
66Acute myeloid leukemia_Homo sapiens_hsa052210.65967887
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.63501830
68PPAR signaling pathway_Homo sapiens_hsa033200.63442345
69Sphingolipid metabolism_Homo sapiens_hsa006000.60359197
70Apoptosis_Homo sapiens_hsa042100.58163473
71Sulfur metabolism_Homo sapiens_hsa009200.57409018
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56936984
73Hepatitis C_Homo sapiens_hsa051600.56173936
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55556045
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.55337953
76VEGF signaling pathway_Homo sapiens_hsa043700.51305202
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.48070712
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45829976
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.44366477
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43970445
81Renin secretion_Homo sapiens_hsa049240.40997820
82Hepatitis B_Homo sapiens_hsa051610.39492066
83Glycerolipid metabolism_Homo sapiens_hsa005610.39144393
84Pancreatic cancer_Homo sapiens_hsa052120.37064654
85Galactose metabolism_Homo sapiens_hsa000520.36353381
86Glutathione metabolism_Homo sapiens_hsa004800.33484403
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32587173
88Gap junction_Homo sapiens_hsa045400.32540914
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30241094
90Serotonergic synapse_Homo sapiens_hsa047260.29777361
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29558573
92Bladder cancer_Homo sapiens_hsa052190.29253922
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28846970
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.25560240
95Pancreatic secretion_Homo sapiens_hsa049720.25188617
96ECM-receptor interaction_Homo sapiens_hsa045120.25120557
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.21659348
98Synaptic vesicle cycle_Homo sapiens_hsa047210.21371814
99Rap1 signaling pathway_Homo sapiens_hsa040150.20238449
100Notch signaling pathway_Homo sapiens_hsa043300.20115525

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