GGTA2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.86007944
2dopamine transport (GO:0015872)6.32941647
3behavioral response to cocaine (GO:0048148)5.15036463
4water-soluble vitamin biosynthetic process (GO:0042364)4.71126806
5ventricular system development (GO:0021591)4.60245526
6axoneme assembly (GO:0035082)4.47486890
7behavioral response to nicotine (GO:0035095)4.46522340
8base-excision repair, AP site formation (GO:0006285)4.27656822
9positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.26165921
10positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.22785989
11transmission of nerve impulse (GO:0019226)4.22176165
12dendritic spine morphogenesis (GO:0060997)4.13415881
13neuronal action potential (GO:0019228)4.09542206
14regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.09010422
15regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.09010422
16proline transport (GO:0015824)3.94716606
17negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.92433364
18retinal ganglion cell axon guidance (GO:0031290)3.91795536
19regulation of neurotransmitter uptake (GO:0051580)3.88013055
20cilium or flagellum-dependent cell motility (GO:0001539)3.78706987
21epithelial cilium movement (GO:0003351)3.75903011
22regulation of interleukin-6 biosynthetic process (GO:0045408)3.70261384
23peristalsis (GO:0030432)3.69214526
24cAMP catabolic process (GO:0006198)3.62682819
25catecholamine transport (GO:0051937)3.57290828
26synaptic transmission, cholinergic (GO:0007271)3.50652467
27striatum development (GO:0021756)3.48436280
28pyrimidine nucleobase catabolic process (GO:0006208)3.47432069
29mesonephros development (GO:0001823)3.41345621
30detection of temperature stimulus involved in sensory perception (GO:0050961)3.40309533
31detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.40309533
32replicative senescence (GO:0090399)3.38860420
33synaptic transmission, dopaminergic (GO:0001963)3.37617132
34urinary tract smooth muscle contraction (GO:0014848)3.31813873
35gamma-aminobutyric acid transport (GO:0015812)3.28943609
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27392076
37DNA damage induced protein phosphorylation (GO:0006975)3.26099995
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25330317
39cilium movement (GO:0003341)3.24131269
40cyclic nucleotide catabolic process (GO:0009214)3.24067506
41regulation of inositol phosphate biosynthetic process (GO:0010919)3.22193933
42aldehyde catabolic process (GO:0046185)3.08325854
43neural tube formation (GO:0001841)3.08139169
44positive regulation of gastrulation (GO:2000543)3.06086788
45substrate-independent telencephalic tangential migration (GO:0021826)3.03563682
46substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.03563682
47nucleobase catabolic process (GO:0046113)2.98971114
48magnesium ion transport (GO:0015693)2.98710593
49calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98533314
50positive regulation of protein homodimerization activity (GO:0090073)2.98137268
51cerebellar Purkinje cell differentiation (GO:0021702)2.93664263
52protein import into peroxisome matrix (GO:0016558)2.91114963
53myelin assembly (GO:0032288)2.88213599
54auditory receptor cell stereocilium organization (GO:0060088)2.87116148
55prepulse inhibition (GO:0060134)2.86071670
56rRNA catabolic process (GO:0016075)2.84018717
57nonmotile primary cilium assembly (GO:0035058)2.81447872
58regulation of response to food (GO:0032095)2.80822010
59negative regulation of neurotransmitter transport (GO:0051589)2.80429065
60regulation of dopamine secretion (GO:0014059)2.76451188
61viral mRNA export from host cell nucleus (GO:0046784)2.72795097
62potassium ion import (GO:0010107)2.70131299
63positive regulation of mitochondrial fission (GO:0090141)2.68751346
64positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.68748143
65inner ear receptor stereocilium organization (GO:0060122)2.66026884
66maternal behavior (GO:0042711)2.63591277
67cilium morphogenesis (GO:0060271)2.62296059
68sulfation (GO:0051923)2.62167056
69behavioral response to ethanol (GO:0048149)2.61604306
70phasic smooth muscle contraction (GO:0014821)2.60584655
71behavioral defense response (GO:0002209)2.60028791
72behavioral fear response (GO:0001662)2.60028791
73DNA deamination (GO:0045006)2.59800063
74negative regulation of axon guidance (GO:1902668)2.58934586
75cholesterol biosynthetic process (GO:0006695)2.58044110
76detection of temperature stimulus (GO:0016048)2.56743617
77response to cocaine (GO:0042220)2.55864009
78indolalkylamine metabolic process (GO:0006586)2.54938323
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.54908134
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.53388675
81response to lipoprotein particle (GO:0055094)2.53384637
82telencephalon development (GO:0021537)2.53315105
83positive regulation of defense response to virus by host (GO:0002230)2.53154526
84adult walking behavior (GO:0007628)2.53101902
85regulation of timing of cell differentiation (GO:0048505)2.51527962
86response to auditory stimulus (GO:0010996)2.51408343
87neurotransmitter-gated ion channel clustering (GO:0072578)2.50668448
88regulation of development, heterochronic (GO:0040034)2.50226015
89dendritic spine organization (GO:0097061)2.49897728
90auditory behavior (GO:0031223)2.47708330
91sequestering of actin monomers (GO:0042989)2.47529581
92parental behavior (GO:0060746)2.47467913
93negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46893224
94synapse assembly (GO:0007416)2.46871059
95positive regulation of RNA splicing (GO:0033120)2.46447051
96regulation of skeletal muscle contraction (GO:0014819)2.45088132
97regulation of synaptic transmission, dopaminergic (GO:0032225)2.43899807
98neurotransmitter catabolic process (GO:0042135)2.42781364
99hindbrain development (GO:0030902)2.42292074
100isoprenoid biosynthetic process (GO:0008299)2.41475380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.81504599
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.12528335
3GBX2_23144817_ChIP-Seq_PC3_Human4.08718713
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.64909170
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64989544
6FUS_26573619_Chip-Seq_HEK293_Human2.58704925
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50530868
8VDR_22108803_ChIP-Seq_LS180_Human2.37431435
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25343582
10ZNF274_21170338_ChIP-Seq_K562_Hela2.23696582
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16360572
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12652327
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11576899
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.00164319
15TAF15_26573619_Chip-Seq_HEK293_Human1.97094599
16EWS_26573619_Chip-Seq_HEK293_Human1.86800925
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.86559363
18IGF1R_20145208_ChIP-Seq_DFB_Human1.77019243
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66649978
20CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.66644211
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65515804
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61618063
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61560505
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59805031
25P300_19829295_ChIP-Seq_ESCs_Human1.58678085
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58674891
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57427846
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57040976
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55457303
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50937430
31REST_21632747_ChIP-Seq_MESCs_Mouse1.50860517
32TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50217869
33AR_21572438_ChIP-Seq_LNCaP_Human1.49470560
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.48313755
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47951907
36RNF2_27304074_Chip-Seq_NSC_Mouse1.45636575
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44057501
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41208716
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.39573999
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38110006
41CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.37754928
42SMAD4_21799915_ChIP-Seq_A2780_Human1.36372029
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.36292289
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.35822430
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35708802
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35621271
47CBP_20019798_ChIP-Seq_JUKART_Human1.34902834
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34902834
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33535173
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32429353
51TP53_16413492_ChIP-PET_HCT116_Human1.29472293
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.28426161
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.26344852
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25974182
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24984006
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.24690234
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.24397261
58STAT3_23295773_ChIP-Seq_U87_Human1.23266749
59IRF1_19129219_ChIP-ChIP_H3396_Human1.20131985
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19828381
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18397809
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18374917
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18374917
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.16371886
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15710332
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14764949
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14764949
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14330921
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11722401
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11276283
71RUNX2_22187159_ChIP-Seq_PCA_Human1.10008496
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07212231
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07036101
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.06932664
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05833464
76TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05649150
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05541415
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05383867
79ER_23166858_ChIP-Seq_MCF-7_Human1.04978710
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04850798
81AR_20517297_ChIP-Seq_VCAP_Human1.03392711
82P53_22387025_ChIP-Seq_ESCs_Mouse1.01922529
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01621585
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01413356
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01290952
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00173241
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99700496
88SOX2_19829295_ChIP-Seq_ESCs_Human0.99436269
89NANOG_19829295_ChIP-Seq_ESCs_Human0.99436269
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.99155814
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98690416
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.97574622
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97473479
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96781916
95TCF4_23295773_ChIP-Seq_U87_Human0.96455573
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96028996
97GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.95432764
98MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95129254
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.93591498
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.91165618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.23374780
2MP0005171_absent_coat_pigmentation3.20912435
3MP0000569_abnormal_digit_pigmentation2.86341754
4MP0000749_muscle_degeneration2.67739996
5MP0001529_abnormal_vocalization2.57173542
6MP0003656_abnormal_erythrocyte_physiolo2.55098769
7MP0005499_abnormal_olfactory_system2.53746037
8MP0005394_taste/olfaction_phenotype2.53746037
9MP0002822_catalepsy2.36085379
10MP0004147_increased_porphyrin_level2.35812837
11MP0003122_maternal_imprinting2.14129218
12MP0005174_abnormal_tail_pigmentation2.07374080
13MP0009046_muscle_twitch1.97433982
14MP0008789_abnormal_olfactory_epithelium1.94393648
15MP0000372_irregular_coat_pigmentation1.92973536
16MP0003011_delayed_dark_adaptation1.86870193
17MP0002909_abnormal_adrenal_gland1.84607522
18MP0006072_abnormal_retinal_apoptosis1.82460752
19MP0004233_abnormal_muscle_weight1.81305671
20MP0004145_abnormal_muscle_electrophysio1.76290599
21MP0002160_abnormal_reproductive_system1.75522734
22MP0002938_white_spotting1.73013819
23MP0005085_abnormal_gallbladder_physiolo1.71705237
24MP0006276_abnormal_autonomic_nervous1.66827652
25MP0001984_abnormal_olfaction1.63040292
26MP0002163_abnormal_gland_morphology1.62637051
27MP0003183_abnormal_peptide_metabolism1.59161597
28MP0003121_genomic_imprinting1.58158537
29MP0001661_extended_life_span1.57970702
30MP0003959_abnormal_lean_body1.53823360
31MP0003283_abnormal_digestive_organ1.51592946
32MP0004142_abnormal_muscle_tone1.51229678
33MP0002095_abnormal_skin_pigmentation1.50279359
34MP0002928_abnormal_bile_duct1.46308351
35MP0002735_abnormal_chemical_nociception1.45147031
36MP0004742_abnormal_vestibular_system1.43510871
37MP0000015_abnormal_ear_pigmentation1.41184826
38MP0005253_abnormal_eye_physiology1.39574382
39MP0002736_abnormal_nociception_after1.38314405
40MP0005423_abnormal_somatic_nervous1.38098627
41MP0004133_heterotaxia1.35837669
42MP0000778_abnormal_nervous_system1.31696246
43MP0005551_abnormal_eye_electrophysiolog1.31609093
44MP0001664_abnormal_digestion1.30733908
45MP0005389_reproductive_system_phenotype1.26991149
46MP0009745_abnormal_behavioral_response1.23920731
47MP0002269_muscular_atrophy1.22687633
48MP0003195_calcinosis1.19362514
49MP0001919_abnormal_reproductive_system1.17233460
50MP0002752_abnormal_somatic_nervous1.17024748
51MP0008995_early_reproductive_senescence1.16734759
52MP0002272_abnormal_nervous_system1.16346488
53MP0002234_abnormal_pharynx_morphology1.12484820
54MP0002067_abnormal_sensory_capabilities1.12440417
55MP0009379_abnormal_foot_pigmentation1.12041933
56MP0003279_aneurysm1.11539432
57MP0002127_abnormal_cardiovascular_syste1.11231680
58MP0001968_abnormal_touch/_nociception1.10841343
59MP0002102_abnormal_ear_morphology1.10379877
60MP0000566_synostosis1.09905245
61MP0000383_abnormal_hair_follicle1.07691760
62MP0009278_abnormal_bone_marrow1.07303796
63MP0005646_abnormal_pituitary_gland1.06901750
64MP0005195_abnormal_posterior_eye1.05524652
65MP0003252_abnormal_bile_duct1.05259340
66MP0002572_abnormal_emotion/affect_behav1.04742787
67MP0005410_abnormal_fertilization1.04603100
68MP0000955_abnormal_spinal_cord1.03527947
69MP0002882_abnormal_neuron_morphology1.02850187
70MP0003635_abnormal_synaptic_transmissio1.01870082
71MP0002063_abnormal_learning/memory/cond1.01637292
72MP0004130_abnormal_muscle_cell0.97575706
73MP0002733_abnormal_thermal_nociception0.97159338
74MP0002064_seizures0.95674225
75MP0000026_abnormal_inner_ear0.94728811
76MP0003136_yellow_coat_color0.94358501
77MP0008872_abnormal_physiological_respon0.90744745
78MP0000631_abnormal_neuroendocrine_gland0.90253773
79MP0005379_endocrine/exocrine_gland_phen0.90133764
80MP0002653_abnormal_ependyma_morphology0.89064326
81MP0005084_abnormal_gallbladder_morpholo0.88979457
82MP0005075_abnormal_melanosome_morpholog0.88614424
83MP0001764_abnormal_homeostasis0.87512127
84MP0000750_abnormal_muscle_regeneration0.85532143
85MP0002557_abnormal_social/conspecific_i0.85062041
86MP0002638_abnormal_pupillary_reflex0.83580319
87MP0009384_cardiac_valve_regurgitation0.82645355
88MP0002108_abnormal_muscle_morphology0.81539368
89MP0001970_abnormal_pain_threshold0.80546956
90MP0005391_vision/eye_phenotype0.79375525
91MP0002229_neurodegeneration0.79132750
92MP0002152_abnormal_brain_morphology0.78570617
93MP0000538_abnormal_urinary_bladder0.78247345
94MP0000747_muscle_weakness0.77364015
95MP0004134_abnormal_chest_morphology0.76991666
96MP0002751_abnormal_autonomic_nervous0.75317030
97MP0002971_abnormal_brown_adipose0.74388471
98MP0004043_abnormal_pH_regulation0.74377665
99MP0003861_abnormal_nervous_system0.73952204
100MP0005220_abnormal_exocrine_pancreas0.73416732

Predicted human phenotypes

RankGene SetZ-score
1Short tibia (HP:0005736)5.26331537
2Aplasia/Hypoplasia of the tibia (HP:0005772)4.95495899
3Type II lissencephaly (HP:0007260)4.29084065
4Diastasis recti (HP:0001540)4.19805350
5Calf muscle hypertrophy (HP:0008981)3.99930062
6Abnormality of homocysteine metabolism (HP:0010919)3.91791860
7Homocystinuria (HP:0002156)3.91791860
8Muscle hypertrophy of the lower extremities (HP:0008968)3.74340264
9Vertebral arch anomaly (HP:0008438)3.51286649
10Cerebellar dysplasia (HP:0007033)3.51057365
11Stomach cancer (HP:0012126)3.50209273
12Clumsiness (HP:0002312)3.34343125
13Frequent falls (HP:0002359)3.25901195
14Abnormality of macular pigmentation (HP:0008002)3.22278235
15Febrile seizures (HP:0002373)3.15936919
16Broad alveolar ridges (HP:0000187)3.08749857
17Pancreatic fibrosis (HP:0100732)3.04089312
18Abnormality of the lower motor neuron (HP:0002366)3.03724874
19Supernumerary bones of the axial skeleton (HP:0009144)2.98358739
20Retinal dysplasia (HP:0007973)2.98162868
21Chorioretinal atrophy (HP:0000533)2.85466445
22Supernumerary ribs (HP:0005815)2.79735852
23Decreased central vision (HP:0007663)2.75703940
24Hyperventilation (HP:0002883)2.72966606
25Pendular nystagmus (HP:0012043)2.67598151
26Large for gestational age (HP:0001520)2.64407364
27Hemiparesis (HP:0001269)2.55508940
28Genital tract atresia (HP:0001827)2.50317303
29Long nose (HP:0003189)2.46703094
30Gaze-evoked nystagmus (HP:0000640)2.45165621
31Broad-based gait (HP:0002136)2.43170350
32Severe muscular hypotonia (HP:0006829)2.38014016
33Abnormality of the hip-girdle musculature (HP:0001445)2.37789301
34Abnormality of the musculature of the pelvis (HP:0001469)2.37789301
35True hermaphroditism (HP:0010459)2.33337738
36Abolished electroretinogram (ERG) (HP:0000550)2.32933564
37Pachygyria (HP:0001302)2.32587737
38Aplasia/Hypoplasia of the brainstem (HP:0007362)2.32498986
39Hypoplasia of the brainstem (HP:0002365)2.32498986
40Chronic hepatic failure (HP:0100626)2.32168051
41Death in childhood (HP:0003819)2.31474249
42Absent thumb (HP:0009777)2.30740557
43Atonic seizures (HP:0010819)2.30705790
44Pelvic girdle muscle weakness (HP:0003749)2.28801937
45Fibular hypoplasia (HP:0003038)2.28394327
46Severe visual impairment (HP:0001141)2.28098205
47Shoulder girdle muscle weakness (HP:0003547)2.22973414
48Medial flaring of the eyebrow (HP:0010747)2.20549310
49Congenital sensorineural hearing impairment (HP:0008527)2.19185562
50Abnormal respiratory motile cilium morphology (HP:0005938)2.17987022
51Abnormal respiratory epithelium morphology (HP:0012253)2.17987022
52Methylmalonic acidemia (HP:0002912)2.15245821
53Colon cancer (HP:0003003)2.12104281
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11183819
55Rimmed vacuoles (HP:0003805)2.09838858
56Abnormality of the vitamin B12 metabolism (HP:0004341)2.09666975
57Abnormality of the pons (HP:0007361)2.09498216
58Hypothermia (HP:0002045)2.09324051
59Abnormality of methionine metabolism (HP:0010901)2.08598875
60Abnormal ciliary motility (HP:0012262)2.07894351
61Exercise-induced muscle cramps (HP:0003710)2.07559840
62Broad ribs (HP:0000885)2.04837232
63Lissencephaly (HP:0001339)2.03773833
64Myoglobinuria (HP:0002913)2.03133215
65Distal arthrogryposis (HP:0005684)2.02697856
66Abnormality of the calf musculature (HP:0001430)2.02165636
67Severe Myopia (HP:0011003)2.01380215
68Gait imbalance (HP:0002141)1.98494507
69Specific learning disability (HP:0001328)1.98038806
70Hypoplasia of the pons (HP:0012110)1.96485593
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95580023
72Polyphagia (HP:0002591)1.91789075
73Progressive cerebellar ataxia (HP:0002073)1.91372767
74Hypoplasia of the ulna (HP:0003022)1.90127452
75Carpal bone hypoplasia (HP:0001498)1.89988084
76Metaphyseal dysplasia (HP:0100255)1.89440855
77Abnormality of vitamin B metabolism (HP:0004340)1.89280654
78Heterochromia iridis (HP:0001100)1.88170694
79Delayed gross motor development (HP:0002194)1.86298231
80Megaloblastic anemia (HP:0001889)1.85612892
81Congenital primary aphakia (HP:0007707)1.85163265
82Hemiplegia (HP:0002301)1.84960383
83Vaginal atresia (HP:0000148)1.83189528
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.82705660
85Degeneration of the lateral corticospinal tracts (HP:0002314)1.80336325
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80336325
87Abnormality of sulfur amino acid metabolism (HP:0004339)1.80037836
88Absent speech (HP:0001344)1.70555885
89Astigmatism (HP:0000483)1.70027437
90Muscle fiber inclusion bodies (HP:0100299)1.70010543
91Dysdiadochokinesis (HP:0002075)1.69425142
92Abnormal respiratory motile cilium physiology (HP:0012261)1.69072842
93Wide intermamillary distance (HP:0006610)1.68287915
94Patchy hypopigmentation of hair (HP:0011365)1.67798905
95Anterior segment dysgenesis (HP:0007700)1.65959604
96Meningocele (HP:0002435)1.65299795
97Horizontal nystagmus (HP:0000666)1.64443676
98Abnormal biliary tract physiology (HP:0012439)1.64391753
99Bile duct proliferation (HP:0001408)1.64391753
100Nemaline bodies (HP:0003798)1.63363186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF13.61658624
2CAMKK22.49893875
3TLK12.36866121
4NTRK22.28749028
5FRK2.10313886
6MAP4K210.9563467
7TAOK31.84138748
8EPHB11.83105443
9EPHA31.80418365
10PNCK1.77750214
11INSRR1.72454063
12SGK21.69181607
13DYRK31.62908421
14ZAK1.58947884
15BRSK21.56486508
16RIPK11.49243593
17OBSCN1.46763555
18BLK1.46104947
19CASK1.43525618
20PINK11.42543109
21MAP3K21.40792276
22MARK11.37709481
23MAPK151.34178779
24STK111.29048957
25SGK2231.28339947
26SGK4941.28339947
27NTRK11.26872316
28GRK61.26422293
29NTRK31.23541282
30CDK81.17202795
31WNK41.17029237
32FGFR21.15215651
33PHKG21.09995174
34PHKG11.09995174
35CAMK1D1.08557861
36IRAK21.07259680
37KSR20.94753304
38RPS6KB20.91957078
39RPS6KB10.90956913
40TSSK60.90812967
41MAP3K40.90483401
42SGK30.90055710
43DYRK1B0.84900508
44BMPR20.84173066
45TAOK10.78868434
46MAPK130.77973966
47CAMK1G0.77846255
48PAK30.74939633
49MAP2K70.72108807
50ABL20.66585147
51CAMKK10.66187721
52DYRK1A0.64965347
53MAP2K30.63291662
54IRAK10.60092904
55PLK20.55912488
56ADRBK10.53077248
57STK390.49036271
58CDK40.46339885
59PTK2B0.44381334
60PIK3CA0.43390580
61MAPK120.41567145
62IRAK40.41467126
63MAP3K30.40409602
64PRKAA10.39155849
65KSR10.39081025
66CLK10.31757243
67DAPK20.30822514
68STK40.29720078
69ZAP700.29087632
70SGK10.29016048
71STK160.27405265
72FGR0.26894300
73MAP3K70.26674221
74CSNK1A10.26264318
75WEE10.26089964
76RAF10.25992544
77CDK120.25492441
78GRK10.23933495
79RPS6KA40.23916035
80SYK0.23470542
81TNIK0.22912330
82BRSK10.22775914
83JAK20.22651926
84GRK50.22125538
85CAMK10.21795719
86MAP2K40.20958991
87CAMK2A0.20613728
88RET0.19367198
89ABL10.19124523
90PRKG10.18758754
91BCKDK0.18454945
92MAP2K10.18339630
93PRKCQ0.18331878
94PRKAA20.17982191
95AKT10.17057148
96DYRK20.15914775
97PLK30.14538538
98ERBB30.14456983
99PIM10.14302379
100PKN20.13908286

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.57901085
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50546286
3Butanoate metabolism_Homo sapiens_hsa006502.67490531
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57653606
5Steroid biosynthesis_Homo sapiens_hsa001002.36060692
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24508620
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.11581356
8Morphine addiction_Homo sapiens_hsa050322.05088543
9Nicotine addiction_Homo sapiens_hsa050331.98382413
10Gap junction_Homo sapiens_hsa045401.95605244
11Basal transcription factors_Homo sapiens_hsa030221.82902739
12Tryptophan metabolism_Homo sapiens_hsa003801.82721205
13Taste transduction_Homo sapiens_hsa047421.74034567
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68406257
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67422992
16Salivary secretion_Homo sapiens_hsa049701.63904981
17Cocaine addiction_Homo sapiens_hsa050301.63390677
18Phototransduction_Homo sapiens_hsa047441.57071546
19Nitrogen metabolism_Homo sapiens_hsa009101.55573911
20Olfactory transduction_Homo sapiens_hsa047401.51588360
21Axon guidance_Homo sapiens_hsa043601.44210482
22Selenocompound metabolism_Homo sapiens_hsa004501.42548536
23Fanconi anemia pathway_Homo sapiens_hsa034601.37278506
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.35566987
25Circadian entrainment_Homo sapiens_hsa047131.32104328
26Glycerolipid metabolism_Homo sapiens_hsa005611.31986126
27GABAergic synapse_Homo sapiens_hsa047271.28940737
28Linoleic acid metabolism_Homo sapiens_hsa005911.27102771
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26256622
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25055015
31Insulin secretion_Homo sapiens_hsa049111.21680004
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21582586
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20761610
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20685203
35Glutamatergic synapse_Homo sapiens_hsa047241.20072589
36Dilated cardiomyopathy_Homo sapiens_hsa054141.19284359
37Renin secretion_Homo sapiens_hsa049241.15180233
38Parkinsons disease_Homo sapiens_hsa050121.12814934
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11215718
40Estrogen signaling pathway_Homo sapiens_hsa049151.09923550
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08487874
42Cholinergic synapse_Homo sapiens_hsa047251.07925611
43Amphetamine addiction_Homo sapiens_hsa050311.07719430
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07679390
45Cardiac muscle contraction_Homo sapiens_hsa042601.05096926
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05058563
47Peroxisome_Homo sapiens_hsa041461.04677747
48ABC transporters_Homo sapiens_hsa020101.02398652
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98462136
50Pyruvate metabolism_Homo sapiens_hsa006200.98278747
51Ovarian steroidogenesis_Homo sapiens_hsa049130.93644157
52Calcium signaling pathway_Homo sapiens_hsa040200.93064708
53Base excision repair_Homo sapiens_hsa034100.88633825
54Type II diabetes mellitus_Homo sapiens_hsa049300.88520417
55Long-term depression_Homo sapiens_hsa047300.88458338
56Regulation of autophagy_Homo sapiens_hsa041400.88429995
57Dorso-ventral axis formation_Homo sapiens_hsa043200.86361304
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85880830
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84935620
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78593402
61Dopaminergic synapse_Homo sapiens_hsa047280.77924931
62Propanoate metabolism_Homo sapiens_hsa006400.75654427
63Vitamin digestion and absorption_Homo sapiens_hsa049770.72470195
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71516791
65Ether lipid metabolism_Homo sapiens_hsa005650.70819061
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69950542
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.69602952
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68562848
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65626215
70Choline metabolism in cancer_Homo sapiens_hsa052310.65547502
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64478920
72mTOR signaling pathway_Homo sapiens_hsa041500.64379357
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63937960
74Oxytocin signaling pathway_Homo sapiens_hsa049210.63851020
75Purine metabolism_Homo sapiens_hsa002300.63582915
76Thyroid hormone synthesis_Homo sapiens_hsa049180.62372209
77FoxO signaling pathway_Homo sapiens_hsa040680.62104808
78Gastric acid secretion_Homo sapiens_hsa049710.60968504
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59538745
80Basal cell carcinoma_Homo sapiens_hsa052170.59458748
81AMPK signaling pathway_Homo sapiens_hsa041520.59015734
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.58122218
83Circadian rhythm_Homo sapiens_hsa047100.57804551
84cAMP signaling pathway_Homo sapiens_hsa040240.56224504
85Huntingtons disease_Homo sapiens_hsa050160.54467707
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.53661021
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53362700
88Serotonergic synapse_Homo sapiens_hsa047260.53319957
89Oxidative phosphorylation_Homo sapiens_hsa001900.51641760
90Arginine and proline metabolism_Homo sapiens_hsa003300.50418505
91GnRH signaling pathway_Homo sapiens_hsa049120.48931179
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.48710879
93RNA degradation_Homo sapiens_hsa030180.48042118
94Glucagon signaling pathway_Homo sapiens_hsa049220.47799508
95Bile secretion_Homo sapiens_hsa049760.44923456
96Glioma_Homo sapiens_hsa052140.44446017
97Prolactin signaling pathway_Homo sapiens_hsa049170.44055740
98Protein export_Homo sapiens_hsa030600.43909496
99Caffeine metabolism_Homo sapiens_hsa002320.43211425
100Prostate cancer_Homo sapiens_hsa052150.42776035

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