GGTLC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)9.71847332
2* unsaturated fatty acid biosynthetic process (GO:0006636)8.84779723
3bundle of His cell to Purkinje myocyte communication (GO:0086069)8.59991731
4glutathione biosynthetic process (GO:0006750)8.36575685
5* glutathione metabolic process (GO:0006749)8.21367195
6peptide catabolic process (GO:0043171)8.00753265
7nonribosomal peptide biosynthetic process (GO:0019184)7.72180116
8detection of molecule of bacterial origin (GO:0032490)7.43192652
9regulation of ER to Golgi vesicle-mediated transport (GO:0060628)5.65282958
10mitochondrion distribution (GO:0048311)5.62548301
11response to pheromone (GO:0019236)5.56106014
12peptide biosynthetic process (GO:0043043)5.48818192
13* icosanoid metabolic process (GO:0006690)5.47148969
14* fatty acid derivative metabolic process (GO:1901568)5.47148969
15phosphatidylethanolamine metabolic process (GO:0046337)4.92446557
16mitochondrial calcium ion transport (GO:0006851)4.70200726
17* unsaturated fatty acid metabolic process (GO:0033559)4.69788949
18microglial cell activation (GO:0001774)4.63088780
19protein ADP-ribosylation (GO:0006471)4.52610050
20cerebellar Purkinje cell differentiation (GO:0021702)4.31729323
21positive regulation by symbiont of host defense response (GO:0052509)4.30646645
22modulation by symbiont of host defense response (GO:0052031)4.30646645
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30646645
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30646645
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.30646645
26modulation by symbiont of host immune response (GO:0052553)4.30646645
27serine family amino acid biosynthetic process (GO:0009070)4.21170977
28glutathione derivative biosynthetic process (GO:1901687)4.05137081
29glutathione derivative metabolic process (GO:1901685)4.05137081
30phosphatidylethanolamine biosynthetic process (GO:0006646)4.00205690
31cellular modified amino acid catabolic process (GO:0042219)3.94128987
32* fatty acid biosynthetic process (GO:0006633)3.81239876
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.77880454
34protein K11-linked deubiquitination (GO:0035871)3.70416710
35regulation of interleukin-6 biosynthetic process (GO:0045408)3.68981005
36alanine transport (GO:0032328)3.67419273
37sulfur amino acid biosynthetic process (GO:0000097)3.66983834
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.56289708
39macrophage activation involved in immune response (GO:0002281)3.54795845
40detection of external biotic stimulus (GO:0098581)3.47805257
41* peptide metabolic process (GO:0006518)3.42569775
42dopamine transport (GO:0015872)3.42360189
43macrophage activation (GO:0042116)3.38577561
44interferon-gamma secretion (GO:0072643)3.35761466
45protein prenylation (GO:0018342)3.31786269
46prenylation (GO:0097354)3.31786269
47cilium or flagellum-dependent cell motility (GO:0001539)3.31733880
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.30875607
49neuronal action potential (GO:0019228)3.27332213
50pathway-restricted SMAD protein phosphorylation (GO:0060389)3.21989542
51glutamate metabolic process (GO:0006536)3.21880300
52androgen biosynthetic process (GO:0006702)3.08771427
53epithelial cilium movement (GO:0003351)3.07018859
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04211222
55histone H3-K9 demethylation (GO:0033169)2.99325587
56neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.97995482
57protein targeting to Golgi (GO:0000042)2.94239813
58negative regulation of cAMP-mediated signaling (GO:0043951)2.91009384
59detection of biotic stimulus (GO:0009595)2.89162242
60negative regulation of neurotransmitter transport (GO:0051589)2.88882258
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87526423
62histone H3-K36 demethylation (GO:0070544)2.85595985
63establishment of protein localization to Golgi (GO:0072600)2.85225863
64proline transport (GO:0015824)2.84218350
65regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.83015373
66regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.83015373
67neural tube formation (GO:0001841)2.80357446
68cell communication involved in cardiac conduction (GO:0086065)2.78416129
69positive regulation of RNA splicing (GO:0033120)2.76623080
70T-helper 1 type immune response (GO:0042088)2.76177172
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75055655
72response to host immune response (GO:0052572)2.75055655
73regulation of membrane depolarization (GO:0003254)2.70994771
74amide biosynthetic process (GO:0043604)2.70846598
75response to acidic pH (GO:0010447)2.69210858
76histone lysine demethylation (GO:0070076)2.63710823
77negative regulation of neurotransmitter secretion (GO:0046929)2.62248089
78prepulse inhibition (GO:0060134)2.61021407
79retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59028988
80gastrulation with mouth forming second (GO:0001702)2.57550814
81Golgi to endosome transport (GO:0006895)2.56636151
82phospholipid translocation (GO:0045332)2.53617856
83lipid translocation (GO:0034204)2.53617856
84histone demethylation (GO:0016577)2.52215822
85histone mRNA catabolic process (GO:0071044)2.50663922
86myelin assembly (GO:0032288)2.49409080
87response to host (GO:0075136)2.45982258
88response to host defenses (GO:0052200)2.45982258
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45982258
90regulation of interferon-beta biosynthetic process (GO:0045357)2.45308490
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45172504
92I-kappaB phosphorylation (GO:0007252)2.43358245
93glycine transport (GO:0015816)2.41472661
94membrane depolarization during action potential (GO:0086010)2.33639958
95oocyte development (GO:0048599)2.33566133
96* leukotriene biosynthetic process (GO:0019370)19.3535413
97* leukotriene metabolic process (GO:0006691)13.1566681
98cysteine metabolic process (GO:0006534)10.9526495
99* icosanoid biosynthetic process (GO:0046456)10.6934722
100* fatty acid derivative biosynthetic process (GO:1901570)10.6934722

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21010070
2GATA1_22025678_ChIP-Seq_K562_Human3.20293100
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80630199
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.72502038
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.53166272
6GBX2_23144817_ChIP-Seq_PC3_Human2.49112698
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29429346
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.22869948
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18895340
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.17611330
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17611330
12TAF15_26573619_Chip-Seq_HEK293_Human2.16125788
13VDR_22108803_ChIP-Seq_LS180_Human2.04809840
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01706477
15SMAD3_21741376_ChIP-Seq_EPCs_Human2.00649085
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99307833
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94430844
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.91873034
19EZH2_22144423_ChIP-Seq_EOC_Human1.90553450
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85593710
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.85222804
22CBP_20019798_ChIP-Seq_JUKART_Human1.85222804
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78639230
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77821907
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74029569
26SMAD4_21741376_ChIP-Seq_EPCs_Human1.71894272
27ER_23166858_ChIP-Seq_MCF-7_Human1.71885568
28AR_21572438_ChIP-Seq_LNCaP_Human1.65702556
29PRDM14_20953172_ChIP-Seq_ESCs_Human1.58068005
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56264925
31VDR_24787735_ChIP-Seq_THP-1_Human1.56098191
32RUNX_20019798_ChIP-Seq_JUKART_Human1.55614094
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50780525
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49730711
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47380304
36P300_19829295_ChIP-Seq_ESCs_Human1.45341991
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45041305
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44223442
39SMAD4_21799915_ChIP-Seq_A2780_Human1.43579840
40TP53_16413492_ChIP-PET_HCT116_Human1.43306073
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.39122005
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38457121
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38314787
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.36693908
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34754215
46OCT1_27270436_Chip-Seq_PROSTATE_Human1.33688879
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33637789
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.33180893
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28990001
50DROSHA_22980978_ChIP-Seq_HELA_Human1.26889184
51SCL_19346495_ChIP-Seq_HPC-7_Human1.26559608
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24884580
53FUS_26573619_Chip-Seq_HEK293_Human1.24507711
54STAT3_23295773_ChIP-Seq_U87_Human1.23717646
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22080665
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.21992749
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.21013394
58SMRT_27268052_Chip-Seq_Bcells_Human1.20228237
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20223073
60MYB_26560356_Chip-Seq_TH2_Human1.19979017
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19561077
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.19512378
63SMAD3_21741376_ChIP-Seq_ESCs_Human1.18808019
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.18598584
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16937547
66CDX2_22108803_ChIP-Seq_LS180_Human1.16679542
67AR_25329375_ChIP-Seq_VCAP_Human1.15663893
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.15397522
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14639728
70TCF4_23295773_ChIP-Seq_U87_Human1.13870163
71GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11721623
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11527233
73TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10411905
74TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09125414
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07910417
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.07774686
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07224336
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07039637
79RUNX2_22187159_ChIP-Seq_PCA_Human1.07015954
80GATA3_26560356_Chip-Seq_TH1_Human1.05825288
81HOXB7_26014856_ChIP-Seq_BT474_Human1.05160587
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04392869
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02692923
84P53_22387025_ChIP-Seq_ESCs_Mouse1.02182786
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01880421
86IRF1_19129219_ChIP-ChIP_H3396_Human1.01605801
87CJUN_26792858_Chip-Seq_BT549_Human1.00662353
88IRF8_27001747_Chip-Seq_BMDM_Mouse0.99958235
89RXR_22108803_ChIP-Seq_LS180_Human0.99303336
90TCF4_22108803_ChIP-Seq_LS180_Human0.98764294
91IRF8_22096565_ChIP-ChIP_GC-B_Human0.98706860
92NCOR_22424771_ChIP-Seq_293T_Human0.98162766
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97520947
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97435152
95NANOG_19829295_ChIP-Seq_ESCs_Human0.97292385
96SOX2_19829295_ChIP-Seq_ESCs_Human0.97292385
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.95490864
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94843453
99BCAT_22108803_ChIP-Seq_LS180_Human0.93986105
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92025283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism8.23059841
2MP0003195_calcinosis6.08214337
3MP0002163_abnormal_gland_morphology6.06841559
4MP0005379_endocrine/exocrine_gland_phen4.31104301
5MP0002736_abnormal_nociception_after4.29798458
6MP0002089_abnormal_postnatal_growth/wei3.94874704
7MP0008995_early_reproductive_senescence3.74809606
8MP0002822_catalepsy3.70625344
9MP0000613_abnormal_salivary_gland3.61084637
10MP0000569_abnormal_digit_pigmentation3.53953738
11MP0001968_abnormal_touch/_nociception3.05899456
12MP0005220_abnormal_exocrine_pancreas2.74666000
13MP0000371_diluted_coat_color2.61453257
14MP0003300_gastrointestinal_ulcer1.93670477
15MP0005410_abnormal_fertilization1.84502183
16MP0003656_abnormal_erythrocyte_physiolo1.69755933
17MP0003011_delayed_dark_adaptation1.49573360
18MP0002277_abnormal_respiratory_mucosa1.48977763
19MP0008877_abnormal_DNA_methylation1.34710238
20MP0003959_abnormal_lean_body1.31338235
21MP0005584_abnormal_enzyme/coenzyme_acti1.29433584
22MP0000858_altered_metastatic_potential1.22814458
23MP0003878_abnormal_ear_physiology1.19493236
24MP0005377_hearing/vestibular/ear_phenot1.19493236
25MP0004742_abnormal_vestibular_system1.18988262
26MP0004484_altered_response_of1.17442626
27MP0003252_abnormal_bile_duct1.12075233
28MP0002009_preneoplasia1.10753559
29MP0005647_abnormal_sex_gland1.07389146
30MP0004264_abnormal_extraembryonic_tissu1.06819507
31MP0009785_altered_susceptibility_to1.05091188
32MP0002075_abnormal_coat/hair_pigmentati1.04724150
33MP0002733_abnormal_thermal_nociception1.03765191
34MP0004019_abnormal_vitamin_homeostasis1.02698347
35MP0001835_abnormal_antigen_presentation0.99962509
36MP0003698_abnormal_male_reproductive0.96374106
37MP0008872_abnormal_physiological_respon0.95561175
38MP0008057_abnormal_DNA_replication0.95085018
39MP0003690_abnormal_glial_cell0.91880013
40MP0001800_abnormal_humoral_immune0.91005672
41MP0004142_abnormal_muscle_tone0.90944817
42MP0002876_abnormal_thyroid_physiology0.90285154
43MP0005332_abnormal_amino_acid0.89008132
44MP0001756_abnormal_urination0.85659398
45MP0005171_absent_coat_pigmentation0.84670410
46MP0005645_abnormal_hypothalamus_physiol0.83988542
47MP0000015_abnormal_ear_pigmentation0.83618281
48MP0005310_abnormal_salivary_gland0.83615545
49MP0002735_abnormal_chemical_nociception0.82398315
50MP0001929_abnormal_gametogenesis0.78095422
51MP0001186_pigmentation_phenotype0.78090579
52MP0008260_abnormal_autophagy0.76901240
53MP0003828_pulmonary_edema0.75966194
54MP0003786_premature_aging0.73333847
55MP0002229_neurodegeneration0.72836622
56MP0002067_abnormal_sensory_capabilities0.72782822
57MP0003045_fibrosis0.72687750
58MP0005671_abnormal_response_to0.70778310
59MP0003943_abnormal_hepatobiliary_system0.70610509
60MP0002272_abnormal_nervous_system0.69460243
61MP0001119_abnormal_female_reproductive0.67419088
62MP0000470_abnormal_stomach_morphology0.66377152
63MP0005551_abnormal_eye_electrophysiolog0.66360678
64MP0002332_abnormal_exercise_endurance0.65901309
65MP0000689_abnormal_spleen_morphology0.64436121
66MP0000163_abnormal_cartilage_morphology0.64396744
67MP0001970_abnormal_pain_threshold0.63851240
68MP0005666_abnormal_adipose_tissue0.62807961
69MP0005375_adipose_tissue_phenotype0.62690024
70MP0001145_abnormal_male_reproductive0.62241645
71MP0003724_increased_susceptibility_to0.62040503
72MP0002723_abnormal_immune_serum0.61193018
73MP0002168_other_aberrant_phenotype0.60861146
74MP0004883_abnormal_blood_vessel0.60184227
75MP0000716_abnormal_immune_system0.60020238
76MP0004924_abnormal_behavior0.59241277
77MP0005386_behavior/neurological_phenoty0.59241277
78MP0001944_abnormal_pancreas_morphology0.59129828
79MP0002166_altered_tumor_susceptibility0.59058651
80MP0010386_abnormal_urinary_bladder0.58667777
81MP0002928_abnormal_bile_duct0.58080016
82MP0001765_abnormal_ion_homeostasis0.56452698
83MP0000013_abnormal_adipose_tissue0.56281113
84MP0000653_abnormal_sex_gland0.55567050
85MP0005075_abnormal_melanosome_morpholog0.53421630
86MP0003763_abnormal_thymus_physiology0.53417596
87MP0002115_abnormal_skeleton_extremities0.53404844
88MP0002108_abnormal_muscle_morphology0.52941638
89MP0005408_hypopigmentation0.50563076
90MP0005174_abnormal_tail_pigmentation0.50379595
91MP0002398_abnormal_bone_marrow0.49369074
92MP0001663_abnormal_digestive_system0.49338177
93MP0002452_abnormal_antigen_presenting0.49153836
94MP0001819_abnormal_immune_cell0.48504046
95MP0002420_abnormal_adaptive_immunity0.47946841
96MP0000639_abnormal_adrenal_gland0.47773073
97MP0002751_abnormal_autonomic_nervous0.47726912
98MP0005334_abnormal_fat_pad0.47593337
99MP0004381_abnormal_hair_follicle0.46751718
100MP0003787_abnormal_imprinting0.46053648

Predicted human phenotypes

RankGene SetZ-score
1Vertebral arch anomaly (HP:0008438)7.27545007
2J-shaped sella turcica (HP:0002680)6.43662333
3Diastasis recti (HP:0001540)6.29086677
4Carpal bone hypoplasia (HP:0001498)6.18471292
5Thoracolumbar scoliosis (HP:0002944)5.88779760
6Broad alveolar ridges (HP:0000187)5.53122120
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.30121389
8Absent/shortened dynein arms (HP:0200106)5.30121389
9Abnormality of liposaccharide metabolism (HP:0010968)5.22702275
10Abnormality of glycosphingolipid metabolism (HP:0004343)5.22702275
11Abnormality of glycolipid metabolism (HP:0010969)5.22702275
12Abnormality of the lumbar spine (HP:0100712)5.04048488
13Broad ribs (HP:0000885)5.01446162
14Flat acetabular roof (HP:0003180)4.63702748
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.49469503
16Deformed sella turcica (HP:0002681)4.15293619
17Thoracic kyphosis (HP:0002942)4.03187925
18Nonprogressive disorder (HP:0003680)4.00613086
19Recurrent bronchitis (HP:0002837)3.96874882
20Aortic regurgitation (HP:0001659)3.94213168
21Flared iliac wings (HP:0002869)3.84452488
22Thickened calvaria (HP:0002684)3.66751610
23Beaking of vertebral bodies (HP:0004568)3.39821536
24Protuberant abdomen (HP:0001538)3.38270240
25Genetic anticipation (HP:0003743)3.24162531
26Palpebral edema (HP:0100540)3.23495157
27Visual hallucinations (HP:0002367)3.17017373
28Abnormal respiratory epithelium morphology (HP:0012253)3.14014730
29Abnormal respiratory motile cilium morphology (HP:0005938)3.14014730
30Abnormality of the sella turcica (HP:0002679)3.03692901
31Abnormal ciliary motility (HP:0012262)2.96112959
32Abnormality of the thoracic spine (HP:0100711)2.92822006
33Aplasia/Hypoplasia of the scapulae (HP:0006713)2.76639738
34Hypoplastic scapulae (HP:0000882)2.76639738
35Abnormality of the fovea (HP:0000493)2.76520552
36Abnormality of the alveolar ridges (HP:0006477)2.76267720
37Slow saccadic eye movements (HP:0000514)2.76087164
38Acne (HP:0001061)2.72973287
39Bronchitis (HP:0012387)2.65168767
40Severe visual impairment (HP:0001141)2.59423870
41Severe global developmental delay (HP:0011344)2.55513986
42Gonadotropin excess (HP:0000837)2.51162705
43Mucopolysacchariduria (HP:0008155)2.50721042
44Urinary glycosaminoglycan excretion (HP:0003541)2.50721042
45Hypoplasia of the odontoid process (HP:0003311)2.49714865
46Corneal dystrophy (HP:0001131)2.37524910
47Postural instability (HP:0002172)2.29637497
48Abnormal respiratory motile cilium physiology (HP:0012261)2.29522643
49Recurrent pneumonia (HP:0006532)2.27733358
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26292367
51Abnormality of polysaccharide metabolism (HP:0011012)2.26292367
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26292367
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25820032
54Craniofacial hyperostosis (HP:0004493)2.22876216
55Homocystinuria (HP:0002156)2.19886642
56Abnormality of homocysteine metabolism (HP:0010919)2.19886642
57Dysostosis multiplex (HP:0000943)2.17281034
58Aplasia/Hypoplasia of the macula (HP:0008059)2.17249877
59Abnormality of the odontoid process (HP:0003310)2.17205674
60Death in childhood (HP:0003819)2.15485269
61Hypoplasia of the fovea (HP:0007750)2.14832165
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.14832165
63Anomalous pulmonary venous return (HP:0010772)2.10718060
64Hoarse voice (HP:0001609)2.09358682
65Abnormal rod and cone electroretinograms (HP:0008323)2.04639150
66Wide intermamillary distance (HP:0006610)2.03822079
67Pathologic fracture (HP:0002756)2.03649995
68Abnormality of macular pigmentation (HP:0008002)2.00073703
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98203862
70Clumsiness (HP:0002312)1.97919078
71Microcytic anemia (HP:0001935)1.97776347
72Aplasia/Hypoplasia affecting the retina (HP:0008061)1.97632341
73Short ribs (HP:0000773)1.95118913
74Spontaneous hematomas (HP:0007420)1.93590431
75Cavernous hemangioma (HP:0001048)1.89852461
76Cranial hyperostosis (HP:0004437)1.89268644
77Attenuation of retinal blood vessels (HP:0007843)1.89250861
78Lack of skin elasticity (HP:0100679)1.88504724
79Central scotoma (HP:0000603)1.87280730
80Chronic mucocutaneous candidiasis (HP:0002728)1.85806294
81Recurrent cutaneous fungal infections (HP:0011370)1.85806294
82Ovoid vertebral bodies (HP:0003300)1.84103284
83T lymphocytopenia (HP:0005403)1.82930839
84Infertility (HP:0000789)1.82928767
85Abnormality of the pulmonary veins (HP:0011718)1.81840959
86Abnormality of the wing of the ilium (HP:0011867)1.80016235
87Abnormality of the aortic arch (HP:0012303)1.77845007
88Hypoplasia of the thymus (HP:0000778)1.76954058
89Gonadal dysgenesis (HP:0000133)1.70531359
90Pancreatic fibrosis (HP:0100732)1.70489514
91Pustule (HP:0200039)1.68297337
92Degeneration of the lateral corticospinal tracts (HP:0002314)1.66523040
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66523040
94Decreased central vision (HP:0007663)1.65047134
95Hyperkalemia (HP:0002153)1.64600641
96Recurrent lower respiratory tract infections (HP:0002783)1.62500014
97Abnormality of T cell number (HP:0011839)1.62342604
98Tongue fasciculations (HP:0001308)1.60904554
99Progressive cerebellar ataxia (HP:0002073)1.60201069
100Nausea (HP:0002018)1.60160555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.15277227
2MAP3K23.84979760
3FRK3.52849175
4CAMKK23.49179891
5NTRK33.45724492
6MAP2K33.26811597
7PIK3CG2.35311515
8WNK12.32447518
9PINK12.24399774
10PRPF4B1.84779949
11DYRK31.84344391
12YES11.83495061
13TSSK61.77776242
14MAP3K61.76332678
15IRAK41.72752674
16IRAK11.71236600
17MAP3K131.63622461
18STK38L1.59910107
19SGK21.57573695
20EPHA31.51621934
21CAMK41.49442105
22MAP3K51.47849115
23TXK1.46129494
24RIPK41.43607920
25PTK2B1.42884049
26GRK61.40230816
27TYK21.35812636
28GRK51.33405603
29MAP3K71.32834126
30CAMKK11.27261671
31IRAK21.21965767
32DYRK1B1.21919216
33SGK4941.21794393
34SGK2231.21794393
35HIPK21.20003719
36MAP2K61.16299022
37IKBKE1.16110861
38BRD41.14632231
39FES1.10950094
40TEC1.09063881
41ACVR1B1.06605537
42FGR1.01089370
43MAP3K30.99790054
44SYK0.99225141
45BRSK20.97701351
46PIM10.95437815
47GRK70.93946587
48PLK20.93563186
49CDK60.91663893
50NLK0.90983056
51FGFR30.88974213
52UHMK10.88879896
53TGFBR20.88639735
54WNK30.85949570
55ADRBK10.84149491
56NEK90.82630143
57ADRBK20.81522376
58MAP2K40.76325979
59STK110.75069828
60SGK30.74576449
61INSRR0.73007329
62TAF10.71634299
63LYN0.71400331
64RPS6KA40.70325224
65MINK10.69829744
66STK40.69596438
67PDK10.69446820
68SGK10.69371837
69IKBKB0.68090651
70RPS6KB20.66543082
71NTRK20.65184616
72JAK10.64356231
73BMPR20.62418114
74RET0.61292615
75RPS6KA60.59035593
76CSK0.55562707
77JAK20.54979946
78MELK0.54957315
79MATK0.54561905
80LCK0.53458742
81SIK20.51181243
82PLK40.50495536
83ICK0.49796203
84LATS10.49696111
85ZAP700.49546965
86TAOK30.48939246
87PRKG10.47809229
88WNK40.47283955
89DDR20.47180038
90STK380.44733204
91TLK10.43228875
92MAP3K10.43017133
93MAP4K10.42422881
94PDPK10.42205116
95DYRK1A0.41166828
96KIT0.40517119
97CHUK0.39667894
98RPS6KC10.33972971
99RPS6KL10.33972971
100HCK0.33365180

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004307.19229107
2Cyanoamino acid metabolism_Homo sapiens_hsa0046010.5710391
3Selenocompound metabolism_Homo sapiens_hsa004501.76104742
4Maturity onset diabetes of the young_Homo sapiens_hsa049501.54457955
5Amphetamine addiction_Homo sapiens_hsa050311.52297859
6Renin secretion_Homo sapiens_hsa049241.35083342
7Taste transduction_Homo sapiens_hsa047421.35004623
8B cell receptor signaling pathway_Homo sapiens_hsa046621.32767171
9Nicotine addiction_Homo sapiens_hsa050331.32620038
10Arachidonic acid metabolism_Homo sapiens_hsa005901.27441510
11T cell receptor signaling pathway_Homo sapiens_hsa046601.25975717
12Dorso-ventral axis formation_Homo sapiens_hsa043201.23931016
13VEGF signaling pathway_Homo sapiens_hsa043701.23211922
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08858369
15Osteoclast differentiation_Homo sapiens_hsa043801.06430086
16Long-term potentiation_Homo sapiens_hsa047201.00485081
17Cocaine addiction_Homo sapiens_hsa050301.00449771
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98131048
19Morphine addiction_Homo sapiens_hsa050320.94183350
20Leishmaniasis_Homo sapiens_hsa051400.93873179
21Tuberculosis_Homo sapiens_hsa051520.90181143
22Malaria_Homo sapiens_hsa051440.86410525
23Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83316535
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78580324
25GABAergic synapse_Homo sapiens_hsa047270.73402864
26Ovarian steroidogenesis_Homo sapiens_hsa049130.72727897
27Glycerophospholipid metabolism_Homo sapiens_hsa005640.70361069
28Fatty acid biosynthesis_Homo sapiens_hsa000610.68961396
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67973140
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67136354
31Glutamatergic synapse_Homo sapiens_hsa047240.66392768
32Estrogen signaling pathway_Homo sapiens_hsa049150.65003756
33cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64711044
34TNF signaling pathway_Homo sapiens_hsa046680.64380663
35cAMP signaling pathway_Homo sapiens_hsa040240.63982740
36NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63956504
37Toxoplasmosis_Homo sapiens_hsa051450.61724220
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60143007
39Glutathione metabolism_Homo sapiens_hsa004800.59987471
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59986146
41Serotonergic synapse_Homo sapiens_hsa047260.59104101
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.59088352
43Graft-versus-host disease_Homo sapiens_hsa053320.58839965
44Cholinergic synapse_Homo sapiens_hsa047250.58172106
45Staphylococcus aureus infection_Homo sapiens_hsa051500.56851220
46MAPK signaling pathway_Homo sapiens_hsa040100.56738914
47Non-small cell lung cancer_Homo sapiens_hsa052230.56104288
48Platelet activation_Homo sapiens_hsa046110.55558187
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55380616
50Oxytocin signaling pathway_Homo sapiens_hsa049210.52891074
51Olfactory transduction_Homo sapiens_hsa047400.52801545
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.52640876
53Chemokine signaling pathway_Homo sapiens_hsa040620.52302986
54Prolactin signaling pathway_Homo sapiens_hsa049170.50694396
55Inositol phosphate metabolism_Homo sapiens_hsa005620.49603413
56Renin-angiotensin system_Homo sapiens_hsa046140.49037784
57Axon guidance_Homo sapiens_hsa043600.48363625
58Influenza A_Homo sapiens_hsa051640.47611540
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45729608
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44767668
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44207317
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43763098
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41262547
64GnRH signaling pathway_Homo sapiens_hsa049120.41242153
65Wnt signaling pathway_Homo sapiens_hsa043100.41144344
66Glucagon signaling pathway_Homo sapiens_hsa049220.41044101
67Calcium signaling pathway_Homo sapiens_hsa040200.40512272
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40503181
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39607320
70Measles_Homo sapiens_hsa051620.39509220
71Caffeine metabolism_Homo sapiens_hsa002320.39421261
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38155278
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.37779420
74FoxO signaling pathway_Homo sapiens_hsa040680.37593207
75Circadian rhythm_Homo sapiens_hsa047100.37082145
76Prostate cancer_Homo sapiens_hsa052150.37026146
77Antigen processing and presentation_Homo sapiens_hsa046120.36773315
78Chronic myeloid leukemia_Homo sapiens_hsa052200.36281220
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35367491
80One carbon pool by folate_Homo sapiens_hsa006700.35012258
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.34882621
82Alcoholism_Homo sapiens_hsa050340.34177041
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.33448484
84Salivary secretion_Homo sapiens_hsa049700.32767799
85Phototransduction_Homo sapiens_hsa047440.32722345
86Type II diabetes mellitus_Homo sapiens_hsa049300.31864744
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31520777
88Primary immunodeficiency_Homo sapiens_hsa053400.30825707
89Viral carcinogenesis_Homo sapiens_hsa052030.30710862
90Linoleic acid metabolism_Homo sapiens_hsa005910.30527441
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30147892
92Hepatitis B_Homo sapiens_hsa051610.29169867
93Oocyte meiosis_Homo sapiens_hsa041140.28483078
94Autoimmune thyroid disease_Homo sapiens_hsa053200.27563157
95Gap junction_Homo sapiens_hsa045400.25929660
96ABC transporters_Homo sapiens_hsa020100.25556961
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25178670
98Regulation of autophagy_Homo sapiens_hsa041400.24371260
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23434327
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23135074

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »