GGTLC5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spindle assembly involved in mitosis (GO:0090307)9.63773546
2negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)9.59417232
3centriole assembly (GO:0098534)8.16419406
4auditory receptor cell differentiation (GO:0042491)7.67074737
5protein neddylation (GO:0045116)7.48935463
6axoneme assembly (GO:0035082)7.32685882
7microtubule cytoskeleton organization involved in mitosis (GO:1902850)7.30378328
8epithelial cilium movement (GO:0003351)6.92751625
9pattern specification involved in kidney development (GO:0061004)6.51729374
10neuron fate determination (GO:0048664)6.48134675
11nephron tubule morphogenesis (GO:0072078)6.42663791
12nephron epithelium morphogenesis (GO:0072088)6.42663791
13radial glial cell differentiation (GO:0060019)6.27619110
14negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)6.15979319
15receptor recycling (GO:0001881)6.01037783
16astrocyte differentiation (GO:0048708)5.87953278
17axon ensheathment in central nervous system (GO:0032291)5.72711643
18central nervous system myelination (GO:0022010)5.72711643
19histone H3-K36 demethylation (GO:0070544)5.66146654
20negative regulation of oligodendrocyte differentiation (GO:0048715)5.62483310
21neuronal stem cell maintenance (GO:0097150)5.52374062
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.41313613
23chemosensory behavior (GO:0007635)5.15029024
24C4-dicarboxylate transport (GO:0015740)5.01183131
25peptidyl-threonine dephosphorylation (GO:0035970)4.95036714
26peptidyl-lysine dimethylation (GO:0018027)4.73305443
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.64268401
28regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)4.62358653
29left/right pattern formation (GO:0060972)4.57559634
30cilium movement (GO:0003341)4.55050896
31renal tubule morphogenesis (GO:0061333)4.54542097
32inner ear receptor cell differentiation (GO:0060113)4.47571266
33negative regulation of astrocyte differentiation (GO:0048712)4.40753438
34hair cell differentiation (GO:0035315)4.38719607
35histone H3-K9 demethylation (GO:0033169)4.26337618
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.23822531
37segment specification (GO:0007379)4.18932692
38motile cilium assembly (GO:0044458)4.18360403
39short-term memory (GO:0007614)4.11827817
40substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.10877805
41substrate-independent telencephalic tangential migration (GO:0021826)4.10877805
42oligodendrocyte development (GO:0014003)4.03040487
43amine catabolic process (GO:0009310)3.99091862
44cellular biogenic amine catabolic process (GO:0042402)3.99091862
45regulation of NFAT protein import into nucleus (GO:0051532)3.98440452
46microtubule bundle formation (GO:0001578)3.95090819
47regulation of acyl-CoA biosynthetic process (GO:0050812)3.89958600
48regulation of cell maturation (GO:1903429)3.85071650
49cilium morphogenesis (GO:0060271)3.80687960
50response to redox state (GO:0051775)3.80038629
51telencephalon development (GO:0021537)3.73510657
52cardiovascular system development (GO:0072358)3.70359072
53mitotic spindle organization (GO:0007052)3.63534810
54regulation of penile erection (GO:0060405)3.61590448
55negative regulation of gliogenesis (GO:0014014)3.56322518
56regulation of growth hormone secretion (GO:0060123)3.49340277
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47659310
58positive regulation of Notch signaling pathway (GO:0045747)3.46111027
59regulation of podosome assembly (GO:0071801)3.43236665
60negative regulation of glial cell proliferation (GO:0060253)3.41526822
61face development (GO:0060324)3.41198573
62regulation of cofactor metabolic process (GO:0051193)3.39200792
63regulation of coenzyme metabolic process (GO:0051196)3.39200792
64ribosomal small subunit biogenesis (GO:0042274)3.35434135
65appendage development (GO:0048736)3.29984449
66limb development (GO:0060173)3.29984449
67viral transcription (GO:0019083)3.24303612
68polyamine metabolic process (GO:0006595)3.23535129
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20963421
70GTP biosynthetic process (GO:0006183)3.13399455
71regulation of helicase activity (GO:0051095)3.11062258
72translational termination (GO:0006415)3.03255562
73regulation of myelination (GO:0031641)3.03107947
74organelle disassembly (GO:1903008)2.98863558
75intraciliary transport (GO:0042073)2.95941381
76protein localization to cilium (GO:0061512)2.93201394
77regulation of sulfur metabolic process (GO:0042762)2.93005464
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.92854731
79ncRNA 3-end processing (GO:0043628)2.92215884
80N-glycan processing (GO:0006491)2.89249452
81mechanoreceptor differentiation (GO:0042490)2.86980257
82pentose metabolic process (GO:0019321)2.83192729
83positive regulation of BMP signaling pathway (GO:0030513)2.82877111
84behavioral response to ethanol (GO:0048149)2.81362105
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79220604
86positive regulation of meiosis (GO:0045836)2.78321892
87positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.78105993
88regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.78105993
89neural tube development (GO:0021915)2.77498330
90UTP biosynthetic process (GO:0006228)2.75683272
91cell differentiation involved in metanephros development (GO:0072202)2.74294514
92peptidyl-histidine modification (GO:0018202)2.73643075
93regulation of glycogen (starch) synthase activity (GO:2000465)2.69256871
94mitochondrial fusion (GO:0008053)2.67400993
95smoothened signaling pathway (GO:0007224)2.65069036
96chaperone-mediated protein transport (GO:0072321)2.61232466
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.5054397
98embryonic body morphogenesis (GO:0010172)13.5329018
99centriole replication (GO:0007099)11.4555895
100body morphogenesis (GO:0010171)11.1171144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human7.78556974
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.49518015
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.40277300
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.03192015
5IGF1R_20145208_ChIP-Seq_DFB_Human3.83268099
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.47128050
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.24984041
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20190005
9WDR5_24793694_ChIP-Seq_LNCAP_Human2.14630109
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02180036
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00013763
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.00013763
13MYC_18940864_ChIP-ChIP_HL60_Human1.90286420
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89582433
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82377757
16ERA_21632823_ChIP-Seq_H3396_Human1.72383911
17SOX2_18555785_ChIP-Seq_MESCs_Mouse1.71714003
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65097073
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63577546
20BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.62632482
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61561894
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59546378
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.59296554
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57198338
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49508515
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46211996
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.44915070
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42571696
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.42397383
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.41049725
31AR_21572438_ChIP-Seq_LNCaP_Human1.40339062
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36789436
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35644515
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.35390930
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.34549292
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.32808867
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32174703
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.30190556
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.28205214
40STAT1_20625510_ChIP-Seq_HELA_Human1.26814529
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24955057
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.21155467
43CTCF_27219007_Chip-Seq_Bcells_Human1.20700089
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19906931
45TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18981046
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.18674049
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13797727
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13706498
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13401998
50BCOR_27268052_Chip-Seq_Bcells_Human1.11678999
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10412879
52P68_20966046_ChIP-Seq_HELA_Human1.07918656
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06822261
54SMC4_20622854_ChIP-Seq_HELA_Human1.05952246
55RARA_24833708_ChIP-Seq_LIVER_Mouse1.05499806
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05235250
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04665917
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03461104
59NANOG_20526341_ChIP-Seq_ESCs_Human1.03123710
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01863675
61PHF8_20622854_ChIP-Seq_HELA_Human1.01712866
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01439460
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00395298
64E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00112356
65OCT4_20526341_ChIP-Seq_ESCs_Human0.99675981
66DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99283010
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98818342
68FOXP1_21924763_ChIP-Seq_HESCs_Human0.98277135
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97851890
70PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97656607
71HOXB7_26014856_ChIP-Seq_BT474_Human0.97611478
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96620293
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95126625
74MYC_27129775_Chip-Seq_CORNEA_Mouse0.95032708
75PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94412106
76SMAD4_21741376_ChIP-Seq_EPCs_Human0.91213976
77NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89789245
78GABP_19822575_ChIP-Seq_HepG2_Human0.88738056
79TTF2_22483619_ChIP-Seq_HELA_Human0.88485535
80P53_21459846_ChIP-Seq_SAOS-2_Human0.87541519
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87251999
82FLI1_27457419_Chip-Seq_LIVER_Mouse0.86499889
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86347236
84CBP_20019798_ChIP-Seq_JUKART_Human0.84635378
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84635378
86CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84233579
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84060508
88CTCF_20526341_ChIP-Seq_ESCs_Human0.83246612
89VDR_23849224_ChIP-Seq_CD4+_Human0.83014898
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82700038
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81720925
92EZH2_22144423_ChIP-Seq_EOC_Human0.81692981
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81290065
94NANOG_19829295_ChIP-Seq_ESCs_Human0.80459043
95SOX2_19829295_ChIP-Seq_ESCs_Human0.80459043
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80391149
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.79905139
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.79905139
99REST_21632747_ChIP-Seq_MESCs_Mouse0.79098610
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78970830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting6.04508756
2MP0003787_abnormal_imprinting5.08330588
3MP0002909_abnormal_adrenal_gland4.20859888
4MP0002653_abnormal_ependyma_morphology4.17579204
5MP0006292_abnormal_olfactory_placode4.03394007
6MP0000049_abnormal_middle_ear2.93332468
7MP0002735_abnormal_chemical_nociception2.68356541
8MP0001502_abnormal_circadian_rhythm2.53099899
9MP0008789_abnormal_olfactory_epithelium2.51381407
10MP0003786_premature_aging2.38480630
11MP0003121_genomic_imprinting2.26632366
12MP0008995_early_reproductive_senescence2.26430085
13MP0000678_abnormal_parathyroid_gland2.24369490
14MP0001529_abnormal_vocalization2.20863003
15MP0003755_abnormal_palate_morphology2.10926335
16MP0003119_abnormal_digestive_system2.00753686
17MP0002234_abnormal_pharynx_morphology1.91879349
18MP0005394_taste/olfaction_phenotype1.90809294
19MP0005499_abnormal_olfactory_system1.90809294
20MP0000372_irregular_coat_pigmentation1.85527790
21MP0003136_yellow_coat_color1.82145197
22MP0001968_abnormal_touch/_nociception1.81937599
23MP0004043_abnormal_pH_regulation1.79613008
24MP0002138_abnormal_hepatobiliary_system1.78806348
25MP0003938_abnormal_ear_development1.78166487
26MP0000026_abnormal_inner_ear1.76194052
27MP0000015_abnormal_ear_pigmentation1.74680293
28MP0003646_muscle_fatigue1.71867244
29MP0000778_abnormal_nervous_system1.66784795
30MP0002116_abnormal_craniofacial_bone1.63598342
31MP0002095_abnormal_skin_pigmentation1.55700876
32MP0001346_abnormal_lacrimal_gland1.54306205
33MP0005410_abnormal_fertilization1.52906460
34MP0005085_abnormal_gallbladder_physiolo1.50089661
35MP0001299_abnormal_eye_distance/1.49910670
36MP0000631_abnormal_neuroendocrine_gland1.41049418
37MP0001188_hyperpigmentation1.39889379
38MP0002734_abnormal_mechanical_nocicepti1.39848378
39MP0008877_abnormal_DNA_methylation1.37206547
40MP0002572_abnormal_emotion/affect_behav1.32514640
41MP0002272_abnormal_nervous_system1.30638125
42MP0002233_abnormal_nose_morphology1.27680289
43MP0002557_abnormal_social/conspecific_i1.27136208
44MP0001905_abnormal_dopamine_level1.26672055
45MP0002736_abnormal_nociception_after1.25359058
46MP0001984_abnormal_olfaction1.21894048
47MP0004142_abnormal_muscle_tone1.20318254
48MP0005248_abnormal_Harderian_gland1.16830189
49MP0005646_abnormal_pituitary_gland1.15553998
50MP0003115_abnormal_respiratory_system1.14548646
51MP0009379_abnormal_foot_pigmentation1.14232958
52MP0001849_ear_inflammation1.11837577
53MP0002938_white_spotting1.08692252
54MP0008875_abnormal_xenobiotic_pharmacok1.08068571
55MP0003861_abnormal_nervous_system1.07828950
56MP0001661_extended_life_span1.04381160
57MP0002084_abnormal_developmental_patter1.04314488
58MP0002152_abnormal_brain_morphology1.04159285
59MP0002184_abnormal_innervation1.01907168
60MP0002249_abnormal_larynx_morphology1.01674882
61MP0002114_abnormal_axial_skeleton1.01631334
62MP0000681_abnormal_thyroid_gland0.99734126
63MP0001485_abnormal_pinna_reflex0.99101984
64MP0002109_abnormal_limb_morphology0.98391341
65MP0002638_abnormal_pupillary_reflex0.96316607
66MP0001970_abnormal_pain_threshold0.96220201
67MP0001286_abnormal_eye_development0.94711762
68MP0003937_abnormal_limbs/digits/tail_de0.93509885
69MP0002067_abnormal_sensory_capabilities0.93260368
70MP0006276_abnormal_autonomic_nervous0.92917471
71MP0002063_abnormal_learning/memory/cond0.92691370
72MP0003698_abnormal_male_reproductive0.90064681
73MP0010030_abnormal_orbit_morphology0.88205048
74MP0005535_abnormal_body_temperature0.85141202
75MP0002177_abnormal_outer_ear0.84750595
76MP0001929_abnormal_gametogenesis0.81134530
77MP0003880_abnormal_central_pattern0.80773663
78MP0001963_abnormal_hearing_physiology0.80766272
79MP0010307_abnormal_tumor_latency0.79722282
80MP0001986_abnormal_taste_sensitivity0.77965049
81MP0005257_abnormal_intraocular_pressure0.77784661
82MP0005391_vision/eye_phenotype0.76330167
83MP0002210_abnormal_sex_determination0.75979348
84MP0005423_abnormal_somatic_nervous0.75021104
85MP0000613_abnormal_salivary_gland0.73812907
86MP0002092_abnormal_eye_morphology0.72037526
87MP0004885_abnormal_endolymph0.71446140
88MP0008932_abnormal_embryonic_tissue0.70495804
89MP0002081_perinatal_lethality0.70121335
90MP0003634_abnormal_glial_cell0.67132016
91MP0003122_maternal_imprinting0.65685995
92MP0002882_abnormal_neuron_morphology0.64915837
93MP0006082_CNS_inflammation0.64894333
94MP0002752_abnormal_somatic_nervous0.61599959
95MP0002085_abnormal_embryonic_tissue0.61078440
96MP0002282_abnormal_trachea_morphology0.59623420
97MP0002277_abnormal_respiratory_mucosa0.58888939
98MP0000467_abnormal_esophagus_morphology0.58298256
99MP0000955_abnormal_spinal_cord0.57311230
100MP0004742_abnormal_vestibular_system0.57306298

Predicted human phenotypes

RankGene SetZ-score
1Posterior subcapsular cataract (HP:0007787)9.39472264
2Lip pit (HP:0100267)9.04112987
3Median cleft lip (HP:0000161)8.78034269
4Facial hemangioma (HP:0000329)8.56870862
5Broad alveolar ridges (HP:0000187)7.62367432
6Subcapsular cataract (HP:0000523)5.69489363
7Microretrognathia (HP:0000308)5.25131717
8Pancreatic fibrosis (HP:0100732)5.15778413
9Broad palm (HP:0001169)5.15017725
10Neoplasm of the oral cavity (HP:0100649)5.10590294
11Abnormality of the diencephalon (HP:0010662)5.02469768
12Bifid tongue (HP:0010297)4.97707291
13Abnormality of midbrain morphology (HP:0002418)4.94259005
14Molar tooth sign on MRI (HP:0002419)4.94259005
15Milia (HP:0001056)4.91963552
16Cystic liver disease (HP:0006706)4.82401136
17Myelomeningocele (HP:0002475)4.79665739
18Pancreatic cysts (HP:0001737)4.54050490
19Capillary hemangiomas (HP:0005306)4.41861514
20Facial cleft (HP:0002006)4.26943308
21Heterotopia (HP:0002282)4.26272852
22Upper motor neuron abnormality (HP:0002127)4.21117632
23Abnormality of the alveolar ridges (HP:0006477)3.99040350
24Increased number of teeth (HP:0011069)3.73447650
25Femoral bowing (HP:0002980)3.72261425
26Preaxial hand polydactyly (HP:0001177)3.64527618
27Meningocele (HP:0002435)3.47322759
28Exocrine pancreatic insufficiency (HP:0001738)3.33446581
29Polar cataract (HP:0010696)3.30492949
30Wide nose (HP:0000445)3.29583728
31Porencephaly (HP:0002132)3.27246742
32Oligodactyly (hands) (HP:0001180)3.21731426
33Deep philtrum (HP:0002002)3.10733767
34Intestinal atresia (HP:0011100)3.03652739
35Chin dimple (HP:0010751)2.98507106
36Cerebellar dysplasia (HP:0007033)2.84859860
37Tarsal synostosis (HP:0008368)2.82674475
38Type II lissencephaly (HP:0007260)2.75183062
39Dyschromatopsia (HP:0007641)2.69449016
40Thickened nuchal skin fold (HP:0000474)2.63417931
41Deep palmar crease (HP:0006191)2.62307726
42Synostosis involving bones of the lower limbs (HP:0009138)2.56462825
43Synostosis involving bones of the feet (HP:0009140)2.56462825
44Wide intermamillary distance (HP:0006610)2.51877859
45Oligodactyly (HP:0012165)2.48348865
46Polycystic kidney dysplasia (HP:0000113)2.37918848
47Cortical visual impairment (HP:0100704)2.35890341
48Double outlet right ventricle (HP:0001719)2.35855232
49Congenital malformation of the right heart (HP:0011723)2.35855232
50Skin pits (HP:0100276)2.29341560
51Short ribs (HP:0000773)2.27844266
52Abnormality of the acetabulum (HP:0003170)2.26751870
53Tubulointerstitial nephritis (HP:0001970)2.26677693
54Postaxial hand polydactyly (HP:0001162)2.23234353
55Postaxial foot polydactyly (HP:0001830)2.22867672
56Hypoplasia of dental enamel (HP:0006297)2.14985281
57Esophageal atresia (HP:0002032)2.13820018
58Fibular hypoplasia (HP:0003038)2.12352591
59Hamartoma (HP:0010566)2.10469190
60Congenital hepatic fibrosis (HP:0002612)2.07134101
61Congenital hip dislocation (HP:0001374)2.06135473
62CNS hypomyelination (HP:0003429)2.05888464
63Central scotoma (HP:0000603)2.05452274
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.02165627
65Absent/shortened dynein arms (HP:0200106)2.02165627
66Cerebral hypomyelination (HP:0006808)2.01072671
67Omphalocele (HP:0001539)1.99814138
68Abnormality of the parathyroid morphology (HP:0011766)1.96636276
69Pseudobulbar signs (HP:0002200)1.95220759
70Chronic hepatic failure (HP:0100626)1.91308873
71Abnormality of the lower motor neuron (HP:0002366)1.87510321
72Aqueductal stenosis (HP:0002410)1.87312763
73Dandy-Walker malformation (HP:0001305)1.86883087
74Achilles tendon contracture (HP:0001771)1.82744295
75Pendular nystagmus (HP:0012043)1.81600972
76Short thorax (HP:0010306)1.79471172
77Severe muscular hypotonia (HP:0006829)1.78382305
78Coarse hair (HP:0002208)1.76815537
79Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76060277
80Hypoplasia of the brainstem (HP:0002365)1.76060277
81Enlarged epiphyses (HP:0010580)1.76014143
82Anterior segment dysgenesis (HP:0007700)1.75463119
83Dysautonomia (HP:0002459)1.73331607
84Bundle branch block (HP:0011710)1.70754672
85Ectopic anus (HP:0004397)1.70498470
86Severe combined immunodeficiency (HP:0004430)1.68781602
87Acute necrotizing encephalopathy (HP:0006965)1.68481083
88X-linked dominant inheritance (HP:0001423)1.65714484
89Broad distal phalanx of finger (HP:0009836)1.64990272
90Abnormality of the Achilles tendon (HP:0005109)1.63297084
91Retinitis pigmentosa (HP:0000510)1.61608349
92Postural tremor (HP:0002174)1.60814744
93Benign neoplasm of the central nervous system (HP:0100835)1.60655788
94Thyroiditis (HP:0100646)1.58390094
95Abnormal mitochondria in muscle tissue (HP:0008316)1.58021235
96Down-sloping shoulders (HP:0200021)1.57605160
97Cheekbone underdevelopment (HP:0010669)1.55551578
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.54978100
99Tapered finger (HP:0001182)1.54597448
100Underdeveloped nasal alae (HP:0000430)1.54041261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK18.19115963
2LRRK24.71998113
3WNK44.36163573
4CDK193.40417961
5SGK22.92804509
6LATS22.46435204
7SGK2232.37157923
8SGK4942.37157923
9ERN12.21764615
10PNCK2.17216156
11WNK12.11129401
12CAMK1G1.98793691
13PDK21.81649900
14SGK31.80155069
15OXSR11.74518191
16RPS6KC11.62298438
17RPS6KL11.62298438
18PRKCH1.58955580
19PLK41.57534580
20RPS6KA61.51852534
21EPHB21.50462303
22STK111.50456483
23IRAK41.48606451
24RPS6KA21.44196519
25AKT31.40205225
26TIE11.39468020
27CAMK1D1.38446696
28ACVR1B1.38051983
29RPS6KA41.30540548
30TESK11.30313245
31PRKAA21.21640017
32BRAF1.21417578
33DAPK31.15727726
34SIK21.14923751
35IKBKE0.98821598
36TLK10.94545234
37ABL20.90931380
38BMX0.89526044
39CSF1R0.87697111
40INSRR0.85205591
41DMPK0.83503726
42PASK0.83429513
43MET0.76279631
44MAPK70.74056250
45IRAK20.73034064
46PLK20.67610494
47IRAK10.66308325
48HIPK20.63778300
49EPHA40.63600453
50MAPK150.63418373
51PRKAA10.63298916
52PRKCG0.60938277
53NME10.60630432
54MST1R0.59552279
55CAMK10.57605662
56PTK2B0.57398250
57PDPK10.55866432
58SGK10.54357036
59PDK10.50243526
60PTK60.47599683
61PIM10.45729186
62LIMK10.45501197
63BMPR1B0.44302464
64RPS6KA10.42976327
65PAK10.42199051
66GRK70.41266503
67MAP2K10.40955360
68CAMKK20.40809412
69CDC70.39687377
70MAP3K80.39661619
71NEK10.36452799
72AURKA0.35182395
73CDK120.34697306
74CSNK1E0.33981933
75RPS6KA50.33663120
76TNIK0.33305929
77PRKCQ0.31872833
78PRKCE0.30490283
79MAP2K60.30315040
80FGR0.30275036
81WNK30.28185762
82TESK20.27395061
83MAP3K70.26536857
84PINK10.25313758
85NEK20.23998748
86PRKACG0.23463699
87MAP2K20.23014846
88PRKACA0.21531596
89STK40.21075427
90GRK50.20882844
91MTOR0.20519047
92MARK10.20441230
93PRKCZ0.20236242
94PRKCD0.19187460
95CAMK40.18247146
96TAOK30.18162562
97WEE10.16334976
98CDK30.15999037
99PIK3CG0.15988128
100PRKCI0.15355437

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.92013074
2Sulfur relay system_Homo sapiens_hsa041224.14304204
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.46250863
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22006433
5Mismatch repair_Homo sapiens_hsa034303.05139937
6Oxidative phosphorylation_Homo sapiens_hsa001902.89110813
7Huntingtons disease_Homo sapiens_hsa050162.36036157
8Parkinsons disease_Homo sapiens_hsa050122.33533272
9Cardiac muscle contraction_Homo sapiens_hsa042602.30989840
10Notch signaling pathway_Homo sapiens_hsa043302.04327419
11Basal cell carcinoma_Homo sapiens_hsa052171.94259155
12Thyroid hormone synthesis_Homo sapiens_hsa049181.90849591
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90341970
14Fat digestion and absorption_Homo sapiens_hsa049751.89956129
15Alzheimers disease_Homo sapiens_hsa050101.88417015
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.84934100
17Glutathione metabolism_Homo sapiens_hsa004801.81333358
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76848416
19Arachidonic acid metabolism_Homo sapiens_hsa005901.67094587
20Linoleic acid metabolism_Homo sapiens_hsa005911.65271196
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62142090
22Pentose phosphate pathway_Homo sapiens_hsa000301.60986764
23Arginine and proline metabolism_Homo sapiens_hsa003301.53094796
24Fatty acid degradation_Homo sapiens_hsa000711.47472611
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44873856
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44220381
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41186809
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37970072
29Hedgehog signaling pathway_Homo sapiens_hsa043401.34816188
30Circadian rhythm_Homo sapiens_hsa047101.33837858
31Tyrosine metabolism_Homo sapiens_hsa003501.27934214
32Wnt signaling pathway_Homo sapiens_hsa043101.27230440
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21358932
34Hippo signaling pathway_Homo sapiens_hsa043901.19811252
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18064646
36Phenylalanine metabolism_Homo sapiens_hsa003601.13402745
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11758948
38Vitamin digestion and absorption_Homo sapiens_hsa049771.10309678
39RNA degradation_Homo sapiens_hsa030181.09544422
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08771567
41Regulation of autophagy_Homo sapiens_hsa041401.04585442
42Pyrimidine metabolism_Homo sapiens_hsa002401.03610913
43Fatty acid biosynthesis_Homo sapiens_hsa000611.01918828
44Axon guidance_Homo sapiens_hsa043600.99258771
45Colorectal cancer_Homo sapiens_hsa052100.96118294
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.95790711
47Peroxisome_Homo sapiens_hsa041460.90658991
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90327824
49Basal transcription factors_Homo sapiens_hsa030220.89284414
50RNA polymerase_Homo sapiens_hsa030200.87358827
51Caffeine metabolism_Homo sapiens_hsa002320.85430026
52Chemical carcinogenesis_Homo sapiens_hsa052040.84966244
53Taste transduction_Homo sapiens_hsa047420.82284610
54Melanogenesis_Homo sapiens_hsa049160.81202964
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80729764
56Steroid biosynthesis_Homo sapiens_hsa001000.79998036
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75143000
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.74806195
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73423472
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72783031
61Retinol metabolism_Homo sapiens_hsa008300.70429904
62Bile secretion_Homo sapiens_hsa049760.66557567
63Phototransduction_Homo sapiens_hsa047440.64077380
64RNA transport_Homo sapiens_hsa030130.63998279
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.62914800
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62421620
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58757315
68Carbon metabolism_Homo sapiens_hsa012000.57911588
69Purine metabolism_Homo sapiens_hsa002300.55611817
70Metabolic pathways_Homo sapiens_hsa011000.55209367
71Olfactory transduction_Homo sapiens_hsa047400.53189093
72Primary immunodeficiency_Homo sapiens_hsa053400.52531786
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51956889
74Nicotine addiction_Homo sapiens_hsa050330.51585401
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45126869
76TGF-beta signaling pathway_Homo sapiens_hsa043500.43160591
77Spliceosome_Homo sapiens_hsa030400.42677636
78Glycerolipid metabolism_Homo sapiens_hsa005610.41458605
79cAMP signaling pathway_Homo sapiens_hsa040240.40821908
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40652402
81Calcium signaling pathway_Homo sapiens_hsa040200.39067163
82ErbB signaling pathway_Homo sapiens_hsa040120.38122375
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.37922405
84Protein digestion and absorption_Homo sapiens_hsa049740.37864744
85Morphine addiction_Homo sapiens_hsa050320.35710851
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33222288
87Tight junction_Homo sapiens_hsa045300.32449364
88Fanconi anemia pathway_Homo sapiens_hsa034600.31991242
89Insulin resistance_Homo sapiens_hsa049310.30463999
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28892137
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28219694
92Dopaminergic synapse_Homo sapiens_hsa047280.27936977
93Pancreatic secretion_Homo sapiens_hsa049720.25997680
94Glutamatergic synapse_Homo sapiens_hsa047240.25434774
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25159417
96Ether lipid metabolism_Homo sapiens_hsa005650.22719429
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22402790
98Prolactin signaling pathway_Homo sapiens_hsa049170.22060699
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.19837798
100PPAR signaling pathway_Homo sapiens_hsa033200.19759603

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