GH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host immune response (GO:0052553)9.30395651
2positive regulation by symbiont of host defense response (GO:0052509)9.30395651
3modulation by symbiont of host defense response (GO:0052031)9.30395651
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:009.30395651
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:09.30395651
6positive regulation by organism of defense response of other organism involved in symbiotic interact9.30395651
7detection of molecule of bacterial origin (GO:0032490)7.77591898
8macrophage activation involved in immune response (GO:0002281)7.62160028
9microglial cell activation (GO:0001774)6.64304834
10T-helper 1 type immune response (GO:0042088)6.47627828
11response to host immune response (GO:0052572)6.17578249
12response to immune response of other organism involved in symbiotic interaction (GO:0052564)6.17578249
13regulation of interleukin-6 biosynthetic process (GO:0045408)6.02243617
14righting reflex (GO:0060013)5.95460025
15dendritic spine morphogenesis (GO:0060997)5.93531489
16response to defenses of other organism involved in symbiotic interaction (GO:0052173)5.73543032
17response to host (GO:0075136)5.73543032
18response to host defenses (GO:0052200)5.73543032
19regulation of mitochondrial membrane permeability (GO:0046902)5.33149103
20regulation of membrane permeability (GO:0090559)5.13199112
21hepatocyte apoptotic process (GO:0097284)4.82470563
22detection of external biotic stimulus (GO:0098581)4.80745281
23positive regulation of bone remodeling (GO:0046852)4.74752409
24positive regulation of bone resorption (GO:0045780)4.74752409
25cellular response to interleukin-15 (GO:0071350)4.48779915
26macrophage activation (GO:0042116)4.47211752
27hydrogen peroxide biosynthetic process (GO:0050665)4.12847558
28positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.10485588
29cytoskeletal anchoring at plasma membrane (GO:0007016)4.10417114
30detection of biotic stimulus (GO:0009595)4.07439480
31intestinal absorption (GO:0050892)4.01303044
32response to interleukin-15 (GO:0070672)3.98218225
33positive regulation of mast cell degranulation (GO:0043306)3.93116464
34positive regulation of mast cell activation involved in immune response (GO:0033008)3.93116464
35dendrite morphogenesis (GO:0048813)3.84237858
36negative regulation of actin filament bundle assembly (GO:0032232)3.73028060
37labyrinthine layer development (GO:0060711)3.70653768
38bone remodeling (GO:0046849)3.70435578
39reactive oxygen species biosynthetic process (GO:1903409)3.68833497
40otic vesicle formation (GO:0030916)3.66782401
41activation of protein kinase A activity (GO:0034199)3.66387363
42positive regulation of leukocyte degranulation (GO:0043302)3.61282906
43positive regulation of mast cell activation (GO:0033005)3.56228027
44regulation of platelet aggregation (GO:0090330)3.54975586
45negative regulation of platelet activation (GO:0010544)3.53558545
46chemosensory behavior (GO:0007635)3.45296457
47regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.43208277
48regulation of platelet activation (GO:0010543)3.36309632
49positive regulation of Rac GTPase activity (GO:0032855)3.35945982
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34689373
51regulation of gamma-delta T cell differentiation (GO:0045586)3.33222008
52alkaloid metabolic process (GO:0009820)3.27583149
53negative regulation of myotube differentiation (GO:0010832)3.25320712
54regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.24444031
55positive regulation of regulated secretory pathway (GO:1903307)3.21227973
56negative regulation of bone mineralization (GO:0030502)3.20724266
57positive regulation of gamma-delta T cell activation (GO:0046645)3.20289690
58protein localization to synapse (GO:0035418)3.20134642
59regulation of homotypic cell-cell adhesion (GO:0034110)3.19911468
60production of molecular mediator involved in inflammatory response (GO:0002532)3.18635582
61regulation of interferon-beta biosynthetic process (GO:0045357)3.17292413
62microtubule severing (GO:0051013)3.16539535
63histone H4-K12 acetylation (GO:0043983)3.12628541
64epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.07247954
65dendritic spine organization (GO:0097061)3.03602167
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02925416
67motile cilium assembly (GO:0044458)3.02403169
68oxidative demethylation (GO:0070989)3.01252409
69vocalization behavior (GO:0071625)2.99147102
70phospholipid scrambling (GO:0017121)2.96634969
71lung morphogenesis (GO:0060425)2.96019529
72reflex (GO:0060004)2.94835748
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93823683
74myeloid cell activation involved in immune response (GO:0002275)2.92832559
75intestinal cholesterol absorption (GO:0030299)2.90419212
76cAMP biosynthetic process (GO:0006171)2.87088559
77serotonin metabolic process (GO:0042428)2.79894360
78mitochondrial membrane organization (GO:0007006)2.78112152
79omega-hydroxylase P450 pathway (GO:0097267)2.76944705
80dopaminergic neuron differentiation (GO:0071542)2.76595679
81negative regulation of complement activation (GO:0045916)2.76190249
82negative regulation of biomineral tissue development (GO:0070168)2.76176394
83positive regulation of dendritic spine development (GO:0060999)2.75333538
84striated muscle atrophy (GO:0014891)2.75269038
85positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.72917290
86regulation of phospholipid biosynthetic process (GO:0071071)2.72141815
87neural tube formation (GO:0001841)2.67910035
88exogenous drug catabolic process (GO:0042738)2.66251310
89negative regulation of digestive system process (GO:0060457)2.64473228
90positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64059546
91regulation of gamma-delta T cell activation (GO:0046643)2.63709097
92apoptotic mitochondrial changes (GO:0008637)2.63417946
93positive regulation of canonical Wnt signaling pathway (GO:0090263)2.62715448
94interferon-gamma secretion (GO:0072643)2.61492763
95regulation of NIK/NF-kappaB signaling (GO:1901222)2.59558937
96regulation of histone H3-K27 methylation (GO:0061085)2.59537933
97activation of NF-kappaB-inducing kinase activity (GO:0007250)2.53783724
98synapse assembly (GO:0007416)2.52714450
99negative regulation of protein activation cascade (GO:2000258)2.52488201
100regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)11.2401377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.40741418
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.89236682
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.44357916
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18890531
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02492170
6EZH2_22144423_ChIP-Seq_EOC_Human2.85260986
7IGF1R_20145208_ChIP-Seq_DFB_Human2.69321867
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56771685
9PKCTHETA_26484144_Chip-Seq_BREAST_Human2.15242314
10VDR_22108803_ChIP-Seq_LS180_Human2.05864982
11AHR_22903824_ChIP-Seq_MCF-7_Human2.01168563
12GBX2_23144817_ChIP-Seq_PC3_Human2.00877131
13DROSHA_22980978_ChIP-Seq_HELA_Human1.89428005
14ER_23166858_ChIP-Seq_MCF-7_Human1.81175090
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78351175
16SMAD4_21741376_ChIP-Seq_EPCs_Human1.71945223
17* STAT1_20625510_ChIP-Seq_HELA_Human1.70126264
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67543565
19BCAT_22108803_ChIP-Seq_LS180_Human1.64167935
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63996167
21TP53_16413492_ChIP-PET_HCT116_Human1.62390597
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62181983
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60708867
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60086744
25RUNX_20019798_ChIP-Seq_JUKART_Human1.54802426
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.53962582
27RXR_22108803_ChIP-Seq_LS180_Human1.53292473
28TAF15_26573619_Chip-Seq_HEK293_Human1.50677888
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49462666
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48011868
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42387696
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42176570
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.40665690
34VDR_24787735_ChIP-Seq_THP-1_Human1.40341630
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.38777152
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38341430
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.38173969
38SMAD3_21741376_ChIP-Seq_HESCs_Human1.38105449
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.37955486
40SPI1_23127762_ChIP-Seq_K562_Human1.37005858
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34887778
42P300_19829295_ChIP-Seq_ESCs_Human1.29156839
43SMAD4_21799915_ChIP-Seq_A2780_Human1.28720503
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25372222
45AR_25329375_ChIP-Seq_VCAP_Human1.23132317
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.21524150
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21460124
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.21008470
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20932961
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.19595304
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18770544
52STAT3_23295773_ChIP-Seq_U87_Human1.15282966
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14394419
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13735875
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.13677086
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.11163050
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10413644
58NFYA_21822215_ChIP-Seq_K562_Human1.09409896
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08809563
60REST_21632747_ChIP-Seq_MESCs_Mouse1.08367803
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08310894
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.06399918
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.04778615
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02829308
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02399096
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01874746
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01384892
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00940269
69MYC_27129775_Chip-Seq_CORNEA_Mouse0.99767356
70SMAD3_21741376_ChIP-Seq_ESCs_Human0.99399511
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98415933
72ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97975649
73SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97658609
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96638755
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96333660
76NANOG_18555785_Chip-Seq_ESCs_Mouse0.96303916
77MYB_26560356_Chip-Seq_TH2_Human0.94255356
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.93125762
79KDM2B_26808549_Chip-Seq_REH_Human0.93093666
80SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92706483
81AR_20517297_ChIP-Seq_VCAP_Human0.92521166
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.92264635
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92053896
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91250067
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90957212
86NFYB_21822215_ChIP-Seq_K562_Human0.90813213
87ETV1_20927104_ChIP-Seq_GIST48_Human0.90467979
88KDM2B_26808549_Chip-Seq_JURKAT_Human0.90020730
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89431148
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89431148
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88754168
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88244169
93TCF4_22108803_ChIP-Seq_LS180_Human0.86368567
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86104035
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.84633771
96VDR_24763502_ChIP-Seq_THP-1_Human0.84521402
97SMRT_27268052_Chip-Seq_Bcells_Human0.84427810
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.82824872
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82739164
100GF1_26923725_Chip-Seq_HPCs_Mouse0.82147870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.51666212
2MP0002139_abnormal_hepatobiliary_system4.40258160
3MP0003195_calcinosis2.70356894
4MP0000767_abnormal_smooth_muscle2.65156060
5MP0000678_abnormal_parathyroid_gland2.58010514
6MP0001666_abnormal_nutrient_absorption2.34548436
7MP0004782_abnormal_surfactant_physiolog2.23662922
8MP0003950_abnormal_plasma_membrane2.14626096
9MP0003828_pulmonary_edema2.12397242
10MP0008961_abnormal_basal_metabolism2.12384978
11MP0003724_increased_susceptibility_to2.06922174
12MP0003300_gastrointestinal_ulcer2.00625442
13MP0005451_abnormal_body_composition13.2971625
14MP0004130_abnormal_muscle_cell1.99822727
15MP0003183_abnormal_peptide_metabolism1.96614652
16MP0003303_peritoneal_inflammation1.81414977
17MP0001849_ear_inflammation1.76952267
18MP0010234_abnormal_vibrissa_follicle1.64502913
19MP0003011_delayed_dark_adaptation1.41383556
20MP0008875_abnormal_xenobiotic_pharmacok1.35858597
21MP0009115_abnormal_fat_cell1.33791052
22MP0004381_abnormal_hair_follicle1.32675075
23MP0001177_atelectasis1.27319544
24MP0001835_abnormal_antigen_presentation1.26192397
25MP0005423_abnormal_somatic_nervous1.26128099
26MP0001800_abnormal_humoral_immune1.25750860
27MP0002723_abnormal_immune_serum1.21121527
28MP0002249_abnormal_larynx_morphology1.15301181
29MP0005595_abnormal_vascular_smooth1.14867919
30MP0002127_abnormal_cardiovascular_syste1.14127864
31MP0002933_joint_inflammation1.12835847
32MP0005085_abnormal_gallbladder_physiolo1.08454596
33MP0002133_abnormal_respiratory_system1.08363870
34MP0005388_respiratory_system_phenotype1.08363870
35MP0002419_abnormal_innate_immunity1.04243442
36MP0000428_abnormal_craniofacial_morphol1.04127377
37MP0002452_abnormal_antigen_presenting1.03381148
38MP0003115_abnormal_respiratory_system0.99293010
39MP0002928_abnormal_bile_duct0.97816171
40MP0005025_abnormal_response_to0.96954394
41MP0002420_abnormal_adaptive_immunity0.96673344
42MP0001819_abnormal_immune_cell0.94376506
43MP0006292_abnormal_olfactory_placode0.94293716
44MP0002148_abnormal_hypersensitivity_rea0.90494811
45MP0008872_abnormal_physiological_respon0.90452958
46MP0004883_abnormal_blood_vessel0.89980109
47MP0005310_abnormal_salivary_gland0.89478063
48MP0003045_fibrosis0.88949103
49MP0003943_abnormal_hepatobiliary_system0.88158480
50MP0009785_altered_susceptibility_to0.87331398
51MP0004185_abnormal_adipocyte_glucose0.87142672
52MP0004134_abnormal_chest_morphology0.86269048
53MP0008057_abnormal_DNA_replication0.85975628
54MP0002909_abnormal_adrenal_gland0.85800204
55MP0006138_congestive_heart_failure0.85503897
56MP0000049_abnormal_middle_ear0.80305460
57MP0002160_abnormal_reproductive_system0.74899170
58MP0000427_abnormal_hair_cycle0.73207837
59MP0003221_abnormal_cardiomyocyte_apopto0.73069093
60MP0009053_abnormal_anal_canal0.72893760
61MP0010678_abnormal_skin_adnexa0.72271454
62MP0005464_abnormal_platelet_physiology0.71928550
63MP0001765_abnormal_ion_homeostasis0.71364466
64MP0003283_abnormal_digestive_organ0.70983419
65MP0002398_abnormal_bone_marrow0.69907733
66MP0001529_abnormal_vocalization0.66072548
67MP0005377_hearing/vestibular/ear_phenot0.64914483
68MP0003878_abnormal_ear_physiology0.64914483
69MP0005248_abnormal_Harderian_gland0.64854436
70MP0002998_abnormal_bone_remodeling0.64508945
71MP0003436_decreased_susceptibility_to0.64336838
72MP0004947_skin_inflammation0.64217384
73MP0002168_other_aberrant_phenotype0.63082932
74MP0005410_abnormal_fertilization0.62094325
75MP0002405_respiratory_system_inflammati0.61783834
76MP0005164_abnormal_response_to0.61141524
77MP0004145_abnormal_muscle_electrophysio0.60025675
78MP0002722_abnormal_immune_system0.59992834
79MP0005647_abnormal_sex_gland0.59174054
80MP0000716_abnormal_immune_system0.57624310
81MP0000858_altered_metastatic_potential0.56928473
82MP0009764_decreased_sensitivity_to0.54824661
83MP0003866_abnormal_defecation0.54615656
84MP0002184_abnormal_innervation0.53335718
85MP0000371_diluted_coat_color0.52636129
86MP0000569_abnormal_digit_pigmentation0.51001726
87MP0001663_abnormal_digestive_system0.49244115
88MP0000703_abnormal_thymus_morphology0.47673194
89MP0003806_abnormal_nucleotide_metabolis0.47612443
90MP0005000_abnormal_immune_tolerance0.47256157
91MP0005075_abnormal_melanosome_morpholog0.46995776
92MP0004043_abnormal_pH_regulation0.46501429
93MP0002282_abnormal_trachea_morphology0.46306725
94MP0003948_abnormal_gas_homeostasis0.44919639
95MP0000470_abnormal_stomach_morphology0.44853032
96MP0001968_abnormal_touch/_nociception0.44605945
97MP0001873_stomach_inflammation0.44038612
98MP0000538_abnormal_urinary_bladder0.43729264
99MP0005671_abnormal_response_to0.43392070
100MP0000689_abnormal_spleen_morphology0.42618235

Predicted human phenotypes

RankGene SetZ-score
1Deep palmar crease (HP:0006191)4.96417438
2Constricted visual fields (HP:0001133)4.77453274
3Eczematoid dermatitis (HP:0000976)4.56320483
4Hypobetalipoproteinemia (HP:0003563)4.32854934
5Premature skin wrinkling (HP:0100678)4.24745744
6Selective tooth agenesis (HP:0001592)4.19037652
7Mitral stenosis (HP:0001718)4.14035170
8Recurrent gram-negative bacterial infections (HP:0005420)3.94144125
9Obstructive sleep apnea (HP:0002870)3.89418077
10Gastrointestinal stroma tumor (HP:0100723)3.88203943
11Oligodontia (HP:0000677)3.85310892
12Recurrent bacterial skin infections (HP:0005406)3.80088450
13Impaired platelet aggregation (HP:0003540)3.61237876
14Abnormal platelet function (HP:0011869)3.61237876
15Stomatitis (HP:0010280)3.52244093
16Pustule (HP:0200039)3.51783579
17Recurrent fungal infections (HP:0002841)3.50486574
18Vertebral arch anomaly (HP:0008438)3.41701046
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.28601050
20Increased mean platelet volume (HP:0011877)3.27748245
21Aplasia involving bones of the extremities (HP:0009825)3.17288181
22Aplasia involving bones of the upper limbs (HP:0009823)3.17288181
23Aplasia of the phalanges of the hand (HP:0009802)3.17288181
24Recurrent abscess formation (HP:0002722)3.15394844
25Abnormal platelet volume (HP:0011876)3.01998596
26Hemiplegia (HP:0002301)2.83104803
27Striae distensae (HP:0001065)2.79415702
28Genetic anticipation (HP:0003743)2.76915179
29Eosinophilia (HP:0001880)2.69210170
30Anosmia (HP:0000458)2.64264587
31Polygenic inheritance (HP:0010982)2.54446955
32Lymphopenia (HP:0001888)2.52955005
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51919681
34Recurrent viral infections (HP:0004429)2.50964500
35Agitation (HP:0000713)2.50858235
36Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.50161067
37Muscle fiber splitting (HP:0003555)2.49658343
38B lymphocytopenia (HP:0010976)2.48439407
39Vasculitis (HP:0002633)2.48014863
40Bony spicule pigmentary retinopathy (HP:0007737)2.42964890
41Subacute progressive viral hepatitis (HP:0006572)2.41911315
42Blue irides (HP:0000635)2.39273638
43Conjunctival hamartoma (HP:0100780)2.38277027
44T lymphocytopenia (HP:0005403)2.37441764
45Abnormality of B cell number (HP:0010975)2.36928714
46Areflexia of lower limbs (HP:0002522)2.33399139
47Prolonged bleeding time (HP:0003010)2.32774731
48Menstrual irregularities (HP:0000858)2.32664748
49Papilloma (HP:0012740)2.32210790
50Verrucae (HP:0200043)2.32210790
51Leukocytosis (HP:0001974)2.31647223
52Lack of skin elasticity (HP:0100679)2.27919814
53Large earlobe (HP:0009748)2.23647929
54Poikilocytosis (HP:0004447)2.23498176
55Gynecomastia (HP:0000771)2.19733969
56Coarse hair (HP:0002208)2.19344146
57Recurrent bronchitis (HP:0002837)2.15750345
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.15725255
59Granulocytopenia (HP:0001913)2.14193809
60Recurrent pneumonia (HP:0006532)2.12951764
61Hyporeflexia of lower limbs (HP:0002600)2.12520594
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.11477325
63Difficulty running (HP:0009046)2.05498289
64Erectile abnormalities (HP:0100639)2.04985821
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04894975
66Breast aplasia (HP:0100783)2.01026778
67Abnormality of T cell number (HP:0011839)1.98475054
68Resting tremor (HP:0002322)1.98060647
69Testicular neoplasm (HP:0010788)1.96723658
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94679219
71Abnormal protein N-linked glycosylation (HP:0012347)1.94679219
72Abnormal protein glycosylation (HP:0012346)1.94679219
73Abnormal glycosylation (HP:0012345)1.94679219
74Hematochezia (HP:0002573)1.94165001
75Gonadotropin excess (HP:0000837)1.94072618
76Myositis (HP:0100614)1.93688606
77Epistaxis (HP:0000421)1.93550395
78Fibular aplasia (HP:0002990)1.93414764
79Abnormality of eosinophils (HP:0001879)1.91043859
80Acanthocytosis (HP:0001927)1.88575274
81Abnormality of the heme biosynthetic pathway (HP:0010472)1.88535471
82Pathologic fracture (HP:0002756)1.87445959
83Recurrent skin infections (HP:0001581)1.87263270
84Emphysema (HP:0002097)1.86942209
85Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83954894
86Neoplasm of the heart (HP:0100544)1.83193251
87Abnormality of the proximal phalanges of the hand (HP:0009834)1.82814609
88Long nose (HP:0003189)1.82219235
89Postural instability (HP:0002172)1.82147866
90Periodontitis (HP:0000704)1.81364638
91Chronic obstructive pulmonary disease (HP:0006510)1.81263442
92Obstructive lung disease (HP:0006536)1.81263442
93Increased variability in muscle fiber diameter (HP:0003557)1.81173182
94Melanocytic nevus (HP:0000995)1.80306137
95Facial diplegia (HP:0001349)1.79923016
96Abnormality of the columella (HP:0009929)1.77658126
97Clumsiness (HP:0002312)1.75168960
98Muscle fibrillation (HP:0010546)1.74117344
99Aortic aneurysm (HP:0004942)1.73777310
100Gingivitis (HP:0000230)1.71061938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.54619699
2MAP3K114.54099967
3MAP4K14.12855159
4CDK193.71350883
5MAP3K13.52241961
6FRK3.31398024
7JAK32.75475921
8KSR22.51511447
9MAP3K122.47628983
10PIK3CG2.37118737
11MAP3K22.19468860
12OXSR12.13575539
13GRK62.03564243
14RIPK41.97712482
15ACVR1B1.70191083
16STK41.63813908
17TYK21.63578272
18MAP2K41.63431072
19MAP3K91.60367844
20TAOK11.55278468
21PAK31.52419920
22HIPK21.47269931
23MAP3K131.45803632
24IRAK41.44844228
25BTK1.31268887
26ARAF1.30498525
27CSK1.29080537
28LATS11.28612892
29KSR11.24108684
30JAK21.24036609
31TEC1.22711412
32CAMK1D1.21453826
33BRAF1.20162155
34CDC71.19303855
35STK111.17320607
36PRKD21.13497352
37RAF11.11255291
38SYK1.10296938
39IRAK11.09031190
40ZAP701.08525354
41FES1.06804867
42EPHB21.03149387
43ITK0.98648714
44ERBB20.94748285
45NTRK30.94294380
46PTK2B0.93626672
47HCK0.93206109
48PLK20.91430772
49CAMK1G0.89627963
50CAMKK10.88484511
51CSF1R0.88253559
52PIM10.87585161
53SGK20.84329596
54YES10.83351001
55MARK20.80856912
56PRKAA20.79860024
57IRAK20.76041120
58EPHA30.75408462
59MATK0.74022035
60LYN0.73769042
61IKBKE0.72081902
62MAP3K70.70459931
63BRD40.69682477
64TGFBR20.69432685
65TXK0.69198384
66MOS0.68819338
67CAMKK20.68581725
68PDGFRB0.67200766
69LCK0.64628146
70TAOK30.61038668
71PDK10.59229731
72EPHB10.58665292
73SGK2230.55974168
74SGK4940.55974168
75AKT30.55318293
76FER0.54907631
77PDPK10.53310961
78JAK10.52446481
79SGK30.52391267
80LRRK20.48787074
81DYRK30.47582182
82FYN0.46690569
83FGFR30.44205968
84MAPK70.42956013
85CAMK40.41329976
86MARK30.35567078
87TRIB30.29832481
88CDK40.28194215
89MAP3K30.26104303
90MAP2K20.25444361
91MAP3K50.21977945
92INSR0.21364027
93EIF2AK20.19358669
94KIT0.19052476
95PRKD10.17987571
96EGFR0.15075578
97CAMK10.14886687
98PRKCZ0.13391987
99STK100.12405473
100PAK60.12251246

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.68402883
2Leishmaniasis_Homo sapiens_hsa051402.29564126
3Dorso-ventral axis formation_Homo sapiens_hsa043202.18240245
4Osteoclast differentiation_Homo sapiens_hsa043802.11596940
5Non-small cell lung cancer_Homo sapiens_hsa052232.09583305
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95508798
7Pancreatic cancer_Homo sapiens_hsa052121.85046988
8Platelet activation_Homo sapiens_hsa046111.83713675
9Tuberculosis_Homo sapiens_hsa051521.79720704
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74779143
11Melanoma_Homo sapiens_hsa052181.67721752
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.60670372
13Staphylococcus aureus infection_Homo sapiens_hsa051501.55063878
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48591179
15ABC transporters_Homo sapiens_hsa020101.44857670
16Glioma_Homo sapiens_hsa052141.41384419
17GnRH signaling pathway_Homo sapiens_hsa049121.35850913
18Notch signaling pathway_Homo sapiens_hsa043301.35291172
19Bile secretion_Homo sapiens_hsa049761.34436387
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32767311
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31622672
22Chronic myeloid leukemia_Homo sapiens_hsa052201.29592363
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.29347206
24Estrogen signaling pathway_Homo sapiens_hsa049151.29171756
25Oxytocin signaling pathway_Homo sapiens_hsa049211.28994860
26ErbB signaling pathway_Homo sapiens_hsa040121.25573352
27Renal cell carcinoma_Homo sapiens_hsa052111.24203361
28Morphine addiction_Homo sapiens_hsa050321.21157494
29MAPK signaling pathway_Homo sapiens_hsa040101.20284295
30B cell receptor signaling pathway_Homo sapiens_hsa046621.20042720
31Glutamatergic synapse_Homo sapiens_hsa047241.18852044
32Chemokine signaling pathway_Homo sapiens_hsa040621.17823911
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.17331278
34Dilated cardiomyopathy_Homo sapiens_hsa054141.17066420
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.12375202
36Cholinergic synapse_Homo sapiens_hsa047251.11918445
37Gap junction_Homo sapiens_hsa045401.07111296
38Fatty acid biosynthesis_Homo sapiens_hsa000611.04878243
39Gastric acid secretion_Homo sapiens_hsa049711.03235855
40Salivary secretion_Homo sapiens_hsa049701.02674878
41Hepatitis B_Homo sapiens_hsa051611.02091396
42Ras signaling pathway_Homo sapiens_hsa040141.01960959
43Hematopoietic cell lineage_Homo sapiens_hsa046400.98205830
44Rap1 signaling pathway_Homo sapiens_hsa040150.95315103
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95060622
46Phagosome_Homo sapiens_hsa041450.91073790
47cAMP signaling pathway_Homo sapiens_hsa040240.89871756
48T cell receptor signaling pathway_Homo sapiens_hsa046600.88281458
49Linoleic acid metabolism_Homo sapiens_hsa005910.86097023
50Ovarian steroidogenesis_Homo sapiens_hsa049130.86089317
51Acute myeloid leukemia_Homo sapiens_hsa052210.84534723
52* Jak-STAT signaling pathway_Homo sapiens_hsa046300.80790417
53Circadian entrainment_Homo sapiens_hsa047130.80023207
54Prolactin signaling pathway_Homo sapiens_hsa049170.79935505
55Prostate cancer_Homo sapiens_hsa052150.79421843
56Retinol metabolism_Homo sapiens_hsa008300.78499034
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78259623
58GABAergic synapse_Homo sapiens_hsa047270.77752421
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74623307
60Malaria_Homo sapiens_hsa051440.74622643
61Tryptophan metabolism_Homo sapiens_hsa003800.72248999
62Hepatitis C_Homo sapiens_hsa051600.72121275
63FoxO signaling pathway_Homo sapiens_hsa040680.68798707
64Endometrial cancer_Homo sapiens_hsa052130.68033540
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.65833254
66Toxoplasmosis_Homo sapiens_hsa051450.64724642
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64673171
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63974686
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.62215396
70Choline metabolism in cancer_Homo sapiens_hsa052310.61653821
71Starch and sucrose metabolism_Homo sapiens_hsa005000.61521196
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59912629
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57821065
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57718003
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57644915
76Influenza A_Homo sapiens_hsa051640.57390014
77Chemical carcinogenesis_Homo sapiens_hsa052040.57249641
78Basal transcription factors_Homo sapiens_hsa030220.56945458
79Measles_Homo sapiens_hsa051620.56852533
80* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56476059
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55488214
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54221070
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53709531
84Pancreatic secretion_Homo sapiens_hsa049720.51539733
85Olfactory transduction_Homo sapiens_hsa047400.51463357
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.51244305
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46748452
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.45772530
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.45564503
90MicroRNAs in cancer_Homo sapiens_hsa052060.43611039
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42764296
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42619697
93TNF signaling pathway_Homo sapiens_hsa046680.41647237
94N-Glycan biosynthesis_Homo sapiens_hsa005100.41582066
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41100539
96PPAR signaling pathway_Homo sapiens_hsa033200.40536292
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39548431
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.38553029
99TGF-beta signaling pathway_Homo sapiens_hsa043500.37969520
100Pathways in cancer_Homo sapiens_hsa052000.36081800

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