GHDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.09201007
2axon ensheathment in central nervous system (GO:0032291)6.09201007
3fatty acid elongation (GO:0030497)5.50246444
4negative regulation of erythrocyte differentiation (GO:0045647)5.02048544
5positive regulation of gamma-delta T cell activation (GO:0046645)4.62608090
6long-chain fatty acid biosynthetic process (GO:0042759)4.37771408
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36468533
8antigen processing and presentation of endogenous antigen (GO:0019883)4.33519318
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.15912317
10response to peptidoglycan (GO:0032494)4.09337659
11mannose metabolic process (GO:0006013)4.02776389
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98347525
13negative regulation of cell killing (GO:0031342)3.98347525
14nucleotide transmembrane transport (GO:1901679)3.92108591
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.83216301
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.83216301
17modulation by symbiont of host immune response (GO:0052553)3.83216301
18positive regulation by symbiont of host defense response (GO:0052509)3.83216301
19modulation by symbiont of host defense response (GO:0052031)3.83216301
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.83216301
21neutrophil activation involved in immune response (GO:0002283)3.82077138
22polyol transport (GO:0015791)3.69804980
23limb bud formation (GO:0060174)3.68326396
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67787831
25macrophage activation involved in immune response (GO:0002281)3.66056352
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62132936
27regulation of gamma-delta T cell activation (GO:0046643)3.55307773
28detection of bacterium (GO:0016045)3.54444587
29negative regulation of execution phase of apoptosis (GO:1900118)3.53900416
30immunoglobulin mediated immune response (GO:0016064)3.53848311
31detection of other organism (GO:0098543)3.51873598
32response to muramyl dipeptide (GO:0032495)3.41761318
33positive regulation of cellular amine metabolic process (GO:0033240)3.39843906
34negative regulation of interleukin-12 production (GO:0032695)3.30192714
35germinal center formation (GO:0002467)3.29379117
36myelination (GO:0042552)3.28863567
37axon ensheathment (GO:0008366)3.27663349
38ensheathment of neurons (GO:0007272)3.27663349
39glycerophospholipid catabolic process (GO:0046475)3.26106198
40regulation of mast cell degranulation (GO:0043304)3.26005960
41regulation of gamma-delta T cell differentiation (GO:0045586)3.25951810
42regulation of leukocyte degranulation (GO:0043300)3.25862208
43positive regulation of B cell differentiation (GO:0045579)3.24837632
44NIK/NF-kappaB signaling (GO:0038061)3.24771019
45GPI anchor biosynthetic process (GO:0006506)3.23056793
46glycosphingolipid catabolic process (GO:0046479)3.22990669
47positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.21876583
48presynaptic membrane assembly (GO:0097105)3.21408894
49dopamine biosynthetic process (GO:0042416)3.20888565
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18276715
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.17809101
52L-phenylalanine catabolic process (GO:0006559)3.17809101
53keratinocyte development (GO:0003334)3.14954703
54cholesterol biosynthetic process (GO:0006695)3.14251099
55presynaptic membrane organization (GO:0097090)3.14091860
56GPI anchor metabolic process (GO:0006505)3.13414726
57detection of external biotic stimulus (GO:0098581)3.08514608
58isoprenoid biosynthetic process (GO:0008299)3.07451796
59response to type I interferon (GO:0034340)3.07024710
60type I interferon signaling pathway (GO:0060337)3.06591408
61cellular response to type I interferon (GO:0071357)3.06591408
62pinocytosis (GO:0006907)3.04585626
63photoreceptor cell differentiation (GO:0046530)3.04583222
64eye photoreceptor cell differentiation (GO:0001754)3.04583222
65positive thymic T cell selection (GO:0045059)3.01092883
66regulation of interferon-beta biosynthetic process (GO:0045357)3.01000196
67pyrimidine-containing compound transmembrane transport (GO:0072531)3.00080546
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97110624
69response to redox state (GO:0051775)2.95832418
70negative regulation of neurotransmitter transport (GO:0051589)2.95428931
71B cell receptor signaling pathway (GO:0050853)2.92854372
72regulation of mast cell activation involved in immune response (GO:0033006)2.92085966
73glycolipid catabolic process (GO:0019377)2.89818545
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87296545
75positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86179739
76preassembly of GPI anchor in ER membrane (GO:0016254)2.85675251
77superoxide anion generation (GO:0042554)2.83011716
78import into cell (GO:0098657)2.81223941
79nonribosomal peptide biosynthetic process (GO:0019184)2.81149218
80oligosaccharide catabolic process (GO:0009313)2.80841563
81regulation of superoxide anion generation (GO:0032928)2.79522576
82defense response to protozoan (GO:0042832)2.79370612
83very long-chain fatty acid metabolic process (GO:0000038)2.79018627
84sterol biosynthetic process (GO:0016126)2.78370468
85L-phenylalanine metabolic process (GO:0006558)2.78029727
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.78029727
87nucleotide transport (GO:0006862)2.77597256
88detection of molecule of bacterial origin (GO:0032490)2.77387390
89oligodendrocyte differentiation (GO:0048709)2.77331730
90negative regulation of neurotransmitter secretion (GO:0046929)2.77107369
91response to protozoan (GO:0001562)2.76777382
92interferon-gamma-mediated signaling pathway (GO:0060333)2.76527410
93detection of biotic stimulus (GO:0009595)2.75847390
94negative regulation of protein localization to cell surface (GO:2000009)2.75828814
95regulation of antigen processing and presentation (GO:0002577)2.74901562
96negative regulation of innate immune response (GO:0045824)2.74496267
97cranial nerve development (GO:0021545)2.73595109
98aromatic amino acid family catabolic process (GO:0009074)2.72610181
99peptide catabolic process (GO:0043171)2.71221944
100regulation of necroptotic process (GO:0060544)2.70563221
101neuron remodeling (GO:0016322)2.70028892
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69481113
103cellular response to thyroid hormone stimulus (GO:0097067)2.69364109
104mannosylation (GO:0097502)2.69335673
105response to thyroid hormone (GO:0097066)2.67127329
106regulation of B cell receptor signaling pathway (GO:0050855)2.64774017
107regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64696346
108positive regulation of action potential (GO:0045760)2.64586461
109purine ribonucleotide transport (GO:0015868)2.64543628
110peptide biosynthetic process (GO:0043043)2.64463054
111cellular extravasation (GO:0045123)2.63470174
112myeloid cell activation involved in immune response (GO:0002275)2.62835955
113glutathione biosynthetic process (GO:0006750)2.62750323
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60920926
115response to host immune response (GO:0052572)2.60920926
116ATP synthesis coupled proton transport (GO:0015986)2.60100515
117energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60100515
118positive regulation of antigen processing and presentation (GO:0002579)2.59895198
119negative regulation of cytokine production involved in immune response (GO:0002719)2.58962692
120myeloid dendritic cell differentiation (GO:0043011)2.58509046
121regulation of B cell differentiation (GO:0045577)2.58138969
122catecholamine biosynthetic process (GO:0042423)2.57912910
123catechol-containing compound biosynthetic process (GO:0009713)2.57912910
124regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57864694
125regulation of regulated secretory pathway (GO:1903305)2.57719061
126respiratory electron transport chain (GO:0022904)2.57711159
127negative regulation of myoblast differentiation (GO:0045662)2.57674996
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57357320
129mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55607768
130regulation of necrotic cell death (GO:0010939)2.55585026
131positive regulation of histone deacetylation (GO:0031065)2.53202517
132regulation of T-helper 2 cell differentiation (GO:0045628)2.52825931
133negative regulation of leukocyte mediated immunity (GO:0002704)2.51752035
134N-acetylneuraminate metabolic process (GO:0006054)2.50890216
135sphingoid metabolic process (GO:0046519)2.50403994
136cellular copper ion homeostasis (GO:0006878)2.50231883
137negative regulation of granulocyte differentiation (GO:0030853)2.49948553
138retina layer formation (GO:0010842)2.49713265
139modulation by symbiont of host cellular process (GO:0044068)2.49223797
140negative regulation of interleukin-6 production (GO:0032715)2.49206949
141electron transport chain (GO:0022900)2.49086268
142negative regulation of necroptotic process (GO:0060546)2.48284376
143leukocyte aggregation (GO:0070486)2.47710658
144positive regulation of protein kinase C signaling (GO:0090037)2.47422222
145response to host (GO:0075136)2.46906572
146response to host defenses (GO:0052200)2.46906572
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46906572
148thymic T cell selection (GO:0045061)2.45029364
149macrophage activation (GO:0042116)2.44855549
150amine catabolic process (GO:0009310)2.44794284
151cellular biogenic amine catabolic process (GO:0042402)2.44794284
152mesenchymal cell differentiation involved in kidney development (GO:0072161)2.43744022
153mesenchymal cell differentiation involved in renal system development (GO:2001012)2.43744022
154positive regulation of type 2 immune response (GO:0002830)2.43361858
155positive regulation of cellular amide metabolic process (GO:0034250)2.42678083
156L-amino acid import (GO:0043092)2.42084558
157barbed-end actin filament capping (GO:0051016)2.41759166
158granulocyte activation (GO:0036230)2.41164486
159myeloid dendritic cell activation (GO:0001773)2.40857029
160positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.40781731
161neutrophil activation (GO:0042119)2.39885585
162modulation by virus of host process (GO:0019054)2.39830202
163water-soluble vitamin biosynthetic process (GO:0042364)2.39618210
164B cell mediated immunity (GO:0019724)2.39474337
165negative regulation of lymphocyte mediated immunity (GO:0002707)2.39164049
166positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.39023650
167long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.38566909
168T cell selection (GO:0045058)2.38307481
169amino sugar catabolic process (GO:0046348)2.36642397
170regulation of inositol phosphate biosynthetic process (GO:0010919)2.36279556
171response to lipoprotein particle (GO:0055094)2.35547572
172organ growth (GO:0035265)2.34831297
173glutathione derivative metabolic process (GO:1901685)2.34266587
174glutathione derivative biosynthetic process (GO:1901687)2.34266587
175amyloid precursor protein metabolic process (GO:0042982)2.34097534
176negative regulation of transcription by competitive promoter binding (GO:0010944)2.32742791
177aldehyde catabolic process (GO:0046185)2.28198438
178proteasome assembly (GO:0043248)2.28027625
179sphingosine metabolic process (GO:0006670)2.26857539
180regulation of timing of cell differentiation (GO:0048505)2.26828449
181phosphatidylserine acyl-chain remodeling (GO:0036150)2.26325243
182indole-containing compound catabolic process (GO:0042436)2.25044780
183indolalkylamine catabolic process (GO:0046218)2.25044780
184tryptophan catabolic process (GO:0006569)2.25044780
185protein neddylation (GO:0045116)2.23016235
186purine nucleotide transport (GO:0015865)2.21979654
187magnesium ion transport (GO:0015693)2.21842717
188aromatic amino acid family metabolic process (GO:0009072)2.21366472
189calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.21018194
190regulation of collateral sprouting (GO:0048670)2.20814271
191dopamine transport (GO:0015872)2.20112894
192alkaloid metabolic process (GO:0009820)2.19944081
193androgen biosynthetic process (GO:0006702)2.19050738
194long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.18824450
195ceramide catabolic process (GO:0046514)2.18765254
196tryptophan metabolic process (GO:0006568)2.18698294
197copper ion homeostasis (GO:0055070)2.18594405
198fatty-acyl-CoA biosynthetic process (GO:0046949)2.18412560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.82365328
2VDR_21846776_ChIP-Seq_THP-1_Human3.29781339
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19601113
4GBX2_23144817_ChIP-Seq_PC3_Human3.16326093
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.87199989
6LXR_22292898_ChIP-Seq_THP-1_Human2.76161682
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.65167057
8MYC_22102868_ChIP-Seq_BL_Human2.64796737
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55997215
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52846414
11TAF15_26573619_Chip-Seq_HEK293_Human2.43145524
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37910790
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36755617
14VDR_24763502_ChIP-Seq_THP-1_Human2.35469074
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34694609
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.27913970
17VDR_22108803_ChIP-Seq_LS180_Human2.26826839
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19062091
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.17800648
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15224935
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.13703250
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10665283
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07697864
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05902824
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.05701093
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.03183793
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00848108
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00507435
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99931434
30TCF7_22412390_ChIP-Seq_EML_Mouse1.98136418
31MAF_26560356_Chip-Seq_TH1_Human1.94258693
32KDM2B_26808549_Chip-Seq_DND41_Human1.93620738
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.92458201
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91488233
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.90379820
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90379695
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89509233
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89187422
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.88853650
40EZH2_22144423_ChIP-Seq_EOC_Human1.83441803
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81182422
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.80616566
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.79517435
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78965481
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78740394
46RACK7_27058665_Chip-Seq_MCF-7_Human1.77567413
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76275499
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75886671
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.72885325
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72341037
51UTX_26944678_Chip-Seq_JUKART_Human1.70248458
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.69995149
53SPI1_23127762_ChIP-Seq_K562_Human1.69803177
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69563026
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68860257
56SCL_19346495_ChIP-Seq_HPC-7_Human1.68606779
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68536082
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66851652
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65815532
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65123414
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63745789
62* MAF_26560356_Chip-Seq_TH2_Human1.63503147
63P300_19829295_ChIP-Seq_ESCs_Human1.63471267
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.61812935
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.61677210
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61058006
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60823139
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59925208
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58850437
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57950331
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57384728
72ER_23166858_ChIP-Seq_MCF-7_Human1.56952553
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56854017
74SPI1_23547873_ChIP-Seq_NB4_Human1.56785229
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56506358
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55620573
77P68_20966046_ChIP-Seq_HELA_Human1.55346433
78IGF1R_20145208_ChIP-Seq_DFB_Human1.55086529
79BCOR_27268052_Chip-Seq_Bcells_Human1.54861262
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.54675725
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.54598858
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54587579
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54547121
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53260191
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.52467160
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50189380
87BCL6_27268052_Chip-Seq_Bcells_Human1.49800078
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49368561
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44875377
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44532860
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.43674636
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42251147
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42073185
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41907013
95P53_22387025_ChIP-Seq_ESCs_Mouse1.40847527
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40843932
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.40755018
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.40453488
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.40246589
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39986318
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39982260
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38063492
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36903333
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.36522453
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.36470922
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35851383
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.35544770
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.34889121
109EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34740841
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34740841
111FUS_26573619_Chip-Seq_HEK293_Human1.34227276
112RNF2_27304074_Chip-Seq_NSC_Mouse1.34035049
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33626855
114P300_18555785_Chip-Seq_ESCs_Mouse1.32677641
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.32404705
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31868680
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.30794371
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.29403198
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29059671
120KDM2B_26808549_Chip-Seq_K562_Human1.28480584
121RXR_22158963_ChIP-Seq_LIVER_Mouse1.27905439
122NCOR1_26117541_ChIP-Seq_K562_Human1.27432564
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27123375
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26589158
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26387405
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26109930
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.25697459
128SMAD1_18555785_Chip-Seq_ESCs_Mouse1.25549706
129SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25387333
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24854498
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24527965
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24449572
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24422299
134SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24203940
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24147055
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.23532486
137GATA1_19941826_ChIP-Seq_K562_Human1.23510605
138OCT4_18555785_Chip-Seq_ESCs_Mouse1.23395494
139KDM2B_26808549_Chip-Seq_JURKAT_Human1.22525936
140GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21982197
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21904310
142CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21312011
143HTT_18923047_ChIP-ChIP_STHdh_Human1.21299259
144* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21192614
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20949895
146IRF1_19129219_ChIP-ChIP_H3396_Human1.20680605
147* SMC4_20622854_ChIP-Seq_HELA_Human1.19890418
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19762602
149MYB_26560356_Chip-Seq_TH1_Human1.19745616
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19576300
151CRX_20693478_ChIP-Seq_RETINA_Mouse1.19379582
152ZFX_18555785_Chip-Seq_ESCs_Mouse1.19294050
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19212290
154AR_21572438_ChIP-Seq_LNCaP_Human1.17749287
155* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17175924
156ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15995698
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15948109
158PU1_27457419_Chip-Seq_LIVER_Mouse1.15747138
159FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14537593
160TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14411106
161EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13496898
162FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13335749
163GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13027292
164OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12787159
165* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12498882
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12072426
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11876592
168MYB_26560356_Chip-Seq_TH2_Human1.11424513
169CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11151386
170LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10470731
171UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09621523
172SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09021364
173SMAD4_21799915_ChIP-Seq_A2780_Human1.08308670
174SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07278632
175KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06893991
176CTCF_18555785_Chip-Seq_ESCs_Mouse1.06333727
177WT1_19549856_ChIP-ChIP_CCG9911_Human1.06227893
178SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05984106
179CTCF_26484167_Chip-Seq_Bcells_Mouse1.05591698
180MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05002173
181TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04985529
182RNF2_27304074_Chip-Seq_ESCs_Mouse1.04953954
183KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04324321
184KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04324321
185KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04324321
186CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04009751
187VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03987265
188ESR2_21235772_ChIP-Seq_MCF-7_Human1.03943115
189TP53_18474530_ChIP-ChIP_U2OS_Human1.03659592
190EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03253177
191STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02222763
192MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02135842
193E2F1_20622854_ChIP-Seq_HELA_Human1.01230380
194IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00792621
195RUNX_20019798_ChIP-Seq_JUKART_Human1.00723859
196NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00616296
197NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00616296
198CREB1_26743006_Chip-Seq_LNCaP_Human1.00484227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.50618076
2MP0003436_decreased_susceptibility_to3.50169759
3MP0003136_yellow_coat_color3.39306537
4MP0003195_calcinosis3.28582795
5MP0005451_abnormal_body_composition3.01409024
6MP0000566_synostosis2.97439429
7MP0001835_abnormal_antigen_presentation2.96717501
8MP0000920_abnormal_myelination2.77610550
9MP0004381_abnormal_hair_follicle2.68781194
10MP0002419_abnormal_innate_immunity2.57450181
11MP0003300_gastrointestinal_ulcer2.55708205
12MP0008260_abnormal_autophagy2.50597430
13MP0001790_abnormal_immune_system2.47337999
14MP0005387_immune_system_phenotype2.47337999
15MP0005025_abnormal_response_to2.44053214
16MP0000685_abnormal_immune_system2.43777334
17MP0005000_abnormal_immune_tolerance2.41255616
18MP0003191_abnormal_cellular_cholesterol2.32362991
19MP0001188_hyperpigmentation2.24100878
20MP0001800_abnormal_humoral_immune2.21241024
21MP0002148_abnormal_hypersensitivity_rea2.18122282
22MP0006292_abnormal_olfactory_placode2.16881186
23MP0009278_abnormal_bone_marrow2.16783802
24MP0009785_altered_susceptibility_to2.16120347
25MP0004742_abnormal_vestibular_system2.10071706
26MP0002723_abnormal_immune_serum2.08804142
27MP0005171_absent_coat_pigmentation2.08585289
28MP0005464_abnormal_platelet_physiology2.07046299
29MP0002452_abnormal_antigen_presenting2.07006033
30MP0005409_darkened_coat_color2.06018778
31MP0001905_abnormal_dopamine_level2.05019455
32MP0002102_abnormal_ear_morphology2.03371996
33MP0005671_abnormal_response_to2.02151043
34MP0003718_maternal_effect2.00765987
35MP0002420_abnormal_adaptive_immunity1.97346346
36MP0001819_abnormal_immune_cell1.95191360
37MP0004043_abnormal_pH_regulation1.94715680
38MP0005670_abnormal_white_adipose1.93460738
39MP0005360_urolithiasis1.89590837
40MP0003183_abnormal_peptide_metabolism1.88413537
41MP0002139_abnormal_hepatobiliary_system1.85546675
42MP0002277_abnormal_respiratory_mucosa1.82862376
43MP0001986_abnormal_taste_sensitivity1.80078304
44MP0001661_extended_life_span1.78485848
45MP0001533_abnormal_skeleton_physiology1.78127992
46MP0002876_abnormal_thyroid_physiology1.77629025
47MP0009333_abnormal_splenocyte_physiolog1.77286181
48MP0005332_abnormal_amino_acid1.75994506
49MP0003763_abnormal_thymus_physiology1.75236917
50MP0005408_hypopigmentation1.72854987
51MP0010155_abnormal_intestine_physiology1.67985305
52MP0003075_altered_response_to1.66085343
53MP0004947_skin_inflammation1.65582285
54MP0010386_abnormal_urinary_bladder1.64382391
55MP0003950_abnormal_plasma_membrane1.63442879
56MP0004142_abnormal_muscle_tone1.61896276
57MP0003880_abnormal_central_pattern1.60976021
58MP0001845_abnormal_inflammatory_respons1.58316105
59MP0002405_respiratory_system_inflammati1.57882721
60MP0000604_amyloidosis1.51627408
61MP0000716_abnormal_immune_system1.51308173
62MP0003690_abnormal_glial_cell1.50765915
63MP0001545_abnormal_hematopoietic_system1.49192590
64MP0005397_hematopoietic_system_phenotyp1.49192590
65MP0005058_abnormal_lysosome_morphology1.49178645
66MP0002396_abnormal_hematopoietic_system1.48983435
67MP0002398_abnormal_bone_marrow1.48098233
68MP0008469_abnormal_protein_level1.47541431
69MP0002998_abnormal_bone_remodeling1.47072443
70MP0009840_abnormal_foam_cell1.46582138
71MP0006276_abnormal_autonomic_nervous1.46346029
72MP0003724_increased_susceptibility_to1.45624437
73MP0005645_abnormal_hypothalamus_physiol1.45512552
74MP0002638_abnormal_pupillary_reflex1.45437927
75MP0000858_altered_metastatic_potential1.38950775
76MP0001486_abnormal_startle_reflex1.36549870
77MP0005085_abnormal_gallbladder_physiolo1.35064782
78MP0001346_abnormal_lacrimal_gland1.35064185
79MP0004019_abnormal_vitamin_homeostasis1.33256330
80MP0001963_abnormal_hearing_physiology1.30882850
81MP0000026_abnormal_inner_ear1.30712620
82MP0001529_abnormal_vocalization1.27858973
83MP0002429_abnormal_blood_cell1.27179734
84MP0001485_abnormal_pinna_reflex1.27039667
85MP0004510_myositis1.25942926
86MP0000689_abnormal_spleen_morphology1.25749176
87MP0000343_altered_response_to1.23451617
88MP0003329_amyloid_beta_deposits1.21834119
89MP0000015_abnormal_ear_pigmentation1.21795178
90MP0002722_abnormal_immune_system1.20907765
91MP0001873_stomach_inflammation1.18505232
92MP0005379_endocrine/exocrine_gland_phen1.18170004
93MP0001853_heart_inflammation1.17444611
94MP0005084_abnormal_gallbladder_morpholo1.16125581
95MP0002272_abnormal_nervous_system1.15178420
96MP0008875_abnormal_xenobiotic_pharmacok1.14689072
97MP0001849_ear_inflammation1.14201508
98MP0000462_abnormal_digestive_system1.13527749
99MP0002735_abnormal_chemical_nociception1.12190730
100MP0005365_abnormal_bile_salt1.10199062
101MP0009764_decreased_sensitivity_to1.10100581
102MP0002295_abnormal_pulmonary_circulatio1.09179832
103MP0000538_abnormal_urinary_bladder1.08880098
104MP0005166_decreased_susceptibility_to1.06749313
105MP0003866_abnormal_defecation1.04795596
106MP0002132_abnormal_respiratory_system1.04749157
107MP0002933_joint_inflammation1.04031558
108MP0003938_abnormal_ear_development1.03574402
109MP0005551_abnormal_eye_electrophysiolog1.02391441
110MP0000383_abnormal_hair_follicle1.01746073
111MP0002098_abnormal_vibrissa_morphology1.01313161
112MP0000465_gastrointestinal_hemorrhage1.00775300
113MP0003186_abnormal_redox_activity0.99637174
114MP0003172_abnormal_lysosome_physiology0.99168994
115MP0009379_abnormal_foot_pigmentation0.98559751
116MP0001502_abnormal_circadian_rhythm0.98177213
117MP0002229_neurodegeneration0.98018365
118MP0001727_abnormal_embryo_implantation0.97491898
119MP0004782_abnormal_surfactant_physiolog0.95668486
120MP0000681_abnormal_thyroid_gland0.95493066
121MP0003634_abnormal_glial_cell0.94333968
122MP0001851_eye_inflammation0.93932193
123MP0005666_abnormal_adipose_tissue0.93569219
124MP0002138_abnormal_hepatobiliary_system0.93065416
125MP0009643_abnormal_urine_homeostasis0.92931860
126MP0005075_abnormal_melanosome_morpholog0.92774967
127MP0005395_other_phenotype0.91551877
128MP0000703_abnormal_thymus_morphology0.91207475
129MP0000613_abnormal_salivary_gland0.89386949
130MP0000778_abnormal_nervous_system0.88707797
131MP0003705_abnormal_hypodermis_morpholog0.88560247
132MP0003453_abnormal_keratinocyte_physiol0.87550203
133MP0008004_abnormal_stomach_pH0.87436604
134MP0004134_abnormal_chest_morphology0.87387026
135MP0002938_white_spotting0.86494753
136MP0001663_abnormal_digestive_system0.86150592
137MP0005076_abnormal_cell_differentiation0.85757002
138MP0006082_CNS_inflammation0.85490429
139MP0000609_abnormal_liver_physiology0.85434230
140MP0003941_abnormal_skin_development0.84917179
141MP0004808_abnormal_hematopoietic_stem0.83465359
142MP0005390_skeleton_phenotype0.82101931
143MP0005164_abnormal_response_to0.81683452
144MP0001542_abnormal_bone_strength0.80964006
145MP0002118_abnormal_lipid_homeostasis0.80802554
146MP0010678_abnormal_skin_adnexa0.80258676
147MP0009250_abnormal_appendicular_skeleto0.80138411
148MP0004185_abnormal_adipocyte_glucose0.79728882
149MP0000049_abnormal_middle_ear0.79373878
150MP0003656_abnormal_erythrocyte_physiolo0.79278274
151MP0001664_abnormal_digestion0.78754695
152MP0003878_abnormal_ear_physiology0.78388537
153MP0005377_hearing/vestibular/ear_phenot0.78388537
154MP0004885_abnormal_endolymph0.78368232
155MP0000647_abnormal_sebaceous_gland0.78208925
156MP0009384_cardiac_valve_regurgitation0.78157178
157MP0002752_abnormal_somatic_nervous0.77884904
158MP0001440_abnormal_grooming_behavior0.77694227
159MP0002254_reproductive_system_inflammat0.77634376
160MP0003091_abnormal_cell_migration0.77278233
161MP0003828_pulmonary_edema0.76220404
162MP0002249_abnormal_larynx_morphology0.76128040
163MP0000249_abnormal_blood_vessel0.75687015
164MP0004858_abnormal_nervous_system0.75245793
165MP0003045_fibrosis0.75203532
166MP0000762_abnormal_tongue_morphology0.73161629
167MP0003795_abnormal_bone_structure0.73045841
168MP0005375_adipose_tissue_phenotype0.73001491
169MP0005310_abnormal_salivary_gland0.72964619
170MP0000490_abnormal_crypts_of0.72689297
171MP0005595_abnormal_vascular_smooth0.72637160
172MP0005319_abnormal_enzyme/_coenzyme0.72612840
173MP0005423_abnormal_somatic_nervous0.72557502
174MP0004883_abnormal_blood_vessel0.71989046
175MP0008874_decreased_physiological_sensi0.71852445
176MP0002064_seizures0.70765330
177MP0003632_abnormal_nervous_system0.70203914
178MP0009763_increased_sensitivity_to0.70144452
179MP0002067_abnormal_sensory_capabilities0.69840233
180MP0005535_abnormal_body_temperature0.68121681
181MP0009046_muscle_twitch0.67963819

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.08820031
2Abnormality of liposaccharide metabolism (HP:0010968)4.67370124
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.67370124
4Abnormality of glycolipid metabolism (HP:0010969)4.67370124
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.29823532
6Eczematoid dermatitis (HP:0000976)4.17408176
7Dysostosis multiplex (HP:0000943)4.16547972
8Increased cerebral lipofuscin (HP:0011813)4.15341868
9Abnormality of macrophages (HP:0004311)3.98666998
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.74971888
11Recurrent abscess formation (HP:0002722)3.70975188
12Systemic lupus erythematosus (HP:0002725)3.67287882
13Recurrent bacterial skin infections (HP:0005406)3.60710647
14Myositis (HP:0100614)3.58058811
15Abnormality of polysaccharide metabolism (HP:0011012)3.36583615
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.36583615
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.36583615
18Loss of speech (HP:0002371)3.33551058
19Urinary glycosaminoglycan excretion (HP:0003541)3.23068499
20Mucopolysacchariduria (HP:0008155)3.23068499
21Congenital ichthyosiform erythroderma (HP:0007431)3.22547910
22Elevated erythrocyte sedimentation rate (HP:0003565)3.18469257
23Orchitis (HP:0100796)3.17430198
24Prolonged neonatal jaundice (HP:0006579)3.14360594
25Hypomagnesemia (HP:0002917)3.12873645
26Prolonged partial thromboplastin time (HP:0003645)3.04524596
27Mediastinal lymphadenopathy (HP:0100721)3.03919275
28Recurrent gram-negative bacterial infections (HP:0005420)3.03844991
29Chronic obstructive pulmonary disease (HP:0006510)2.99260466
30Obstructive lung disease (HP:0006536)2.99260466
31Cellulitis (HP:0100658)2.94763402
32Renal Fanconi syndrome (HP:0001994)2.89698080
33Purpura (HP:0000979)2.88303225
34Meningitis (HP:0001287)2.79607289
35Septo-optic dysplasia (HP:0100842)2.78674336
363-Methylglutaconic aciduria (HP:0003535)2.74604546
37Osteomalacia (HP:0002749)2.74063750
38Abnormality of the axillary hair (HP:0100134)2.73060011
39Abnormality of secondary sexual hair (HP:0009888)2.73060011
40Metabolic alkalosis (HP:0200114)2.70398300
41Petechiae (HP:0000967)2.69149357
42Acute necrotizing encephalopathy (HP:0006965)2.67596916
43Recurrent fungal infections (HP:0002841)2.67517012
44Colitis (HP:0002583)2.62828064
45Optic neuritis (HP:0100653)2.62602254
46Retrobulbar optic neuritis (HP:0100654)2.62602254
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61810052
48Gastrointestinal stroma tumor (HP:0100723)2.60087387
49Abnormality of magnesium homeostasis (HP:0004921)2.59239104
50Hypophosphatemic rickets (HP:0004912)2.55969495
51Increased IgE level (HP:0003212)2.55189505
52Acute encephalopathy (HP:0006846)2.54325557
53Patchy hypopigmentation of hair (HP:0011365)2.53560318
54Amyloidosis (HP:0011034)2.53378202
55Glycosuria (HP:0003076)2.52107751
56Abnormality of urine glucose concentration (HP:0011016)2.52107751
57Spontaneous hematomas (HP:0007420)2.51432957
58Abnormality of renal resorption (HP:0011038)2.51352723
59J-shaped sella turcica (HP:0002680)2.49714450
60Recurrent viral infections (HP:0004429)2.49631764
61Generalized aminoaciduria (HP:0002909)2.48303481
62Proximal tubulopathy (HP:0000114)2.47740266
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47608313
64Gastrointestinal inflammation (HP:0004386)2.47600829
65Vacuolated lymphocytes (HP:0001922)2.44835296
66Erythroderma (HP:0001019)2.44259447
67Recurrent skin infections (HP:0001581)2.43974586
68Increased serum ferritin (HP:0003281)2.43830642
69Agammaglobulinemia (HP:0004432)2.41794345
70Split foot (HP:0001839)2.41134765
71Vasculitis (HP:0002633)2.40700857
72Conjugated hyperbilirubinemia (HP:0002908)2.39527547
73Neurofibrillary tangles (HP:0002185)2.39419808
74Gingivitis (HP:0000230)2.38057618
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37157275
76Inflammation of the large intestine (HP:0002037)2.36632855
77Stomatitis (HP:0010280)2.29326897
78White forelock (HP:0002211)2.28413969
79Vertebral compression fractures (HP:0002953)2.27164055
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.25004737
81Glomerulonephritis (HP:0000099)2.24962725
82Abnormality of complement system (HP:0005339)2.24900658
83Epistaxis (HP:0000421)2.24687540
84Prolonged bleeding time (HP:0003010)2.24617363
85Pulmonary infiltrates (HP:0002113)2.23483229
86Interstitial pulmonary disease (HP:0006530)2.23458815
87Nuclear cataract (HP:0100018)2.22179924
88Hypokalemic alkalosis (HP:0001949)2.20352330
89Axonal loss (HP:0003447)2.20184857
90Mitochondrial inheritance (HP:0001427)2.19038723
91Urticaria (HP:0001025)2.17938545
92Progressive macrocephaly (HP:0004481)2.16540445
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.15937036
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15937036
95Pustule (HP:0200039)2.15122162
96Emphysema (HP:0002097)2.14476107
97Spastic paraparesis (HP:0002313)2.12382750
98Complement deficiency (HP:0004431)2.11887434
99Hypertensive crisis (HP:0100735)2.11624381
100Hypothermia (HP:0002045)2.10424336
101Abnormal mitochondria in muscle tissue (HP:0008316)2.10155431
102Thoracic kyphosis (HP:0002942)2.10149265
103Aplasia cutis congenita (HP:0001057)2.09519148
104Chronic mucocutaneous candidiasis (HP:0002728)2.09171707
105Recurrent cutaneous fungal infections (HP:0011370)2.09171707
106Conical tooth (HP:0000698)2.08970806
107Methylmalonic acidemia (HP:0002912)2.08762404
108Abnormality of iron homeostasis (HP:0011031)2.08589756
109Rickets (HP:0002748)2.06930988
110Intrahepatic cholestasis (HP:0001406)2.06839183
111Increased hepatocellular lipid droplets (HP:0006565)2.06090573
112Optic disc pallor (HP:0000543)2.04166405
113Synostosis involving the elbow (HP:0003938)2.04047982
114Humeroradial synostosis (HP:0003041)2.04047982
115Increased circulating renin level (HP:0000848)2.03955333
116Metaphyseal irregularity (HP:0003025)2.03892794
117Hemorrhage of the eye (HP:0011885)2.02700363
118Neuronal loss in central nervous system (HP:0002529)2.00310394
119Cerebral aneurysm (HP:0004944)2.00276732
120Symptomatic seizures (HP:0011145)2.00225264
121Cerebral edema (HP:0002181)1.98980673
122Encephalitis (HP:0002383)1.98887092
123Polygenic inheritance (HP:0010982)1.97026459
124Asymmetric septal hypertrophy (HP:0001670)1.96842677
125Osteomyelitis (HP:0002754)1.96603173
126Nasolacrimal duct obstruction (HP:0000579)1.95682312
127Lipid accumulation in hepatocytes (HP:0006561)1.95399582
128Renal tubular dysfunction (HP:0000124)1.95398189
129Gingival bleeding (HP:0000225)1.95336599
130Restrictive lung disease (HP:0002091)1.94153944
131Gastrointestinal infarctions (HP:0005244)1.92879149
132Abnormal urine phosphate concentration (HP:0012599)1.92206219
133Optic nerve hypoplasia (HP:0000609)1.90047427
134Chest pain (HP:0100749)1.90044098
135Aplasia/hypoplasia of the uterus (HP:0008684)1.89667561
136Progressive neurologic deterioration (HP:0002344)1.89536243
137Hemoptysis (HP:0002105)1.88523373
138Joint hemorrhage (HP:0005261)1.87442856
139Hepatosplenomegaly (HP:0001433)1.86676549
140Absent septum pellucidum (HP:0001331)1.85972893
141Abnormality of the thoracic spine (HP:0100711)1.84957354
142Congenital sensorineural hearing impairment (HP:0008527)1.83277248
143Hypertriglyceridemia (HP:0002155)1.82905228
144Hyperinsulinemic hypoglycemia (HP:0000825)1.82807294
145Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82651666
146Panhypogammaglobulinemia (HP:0003139)1.82211623
147Granulocytopenia (HP:0001913)1.82115206
148Duplication of thumb phalanx (HP:0009942)1.81401756
149Methylmalonic aciduria (HP:0012120)1.81113666
150Lymphopenia (HP:0001888)1.80592050
151Pulmonary embolism (HP:0002204)1.80272569
152Keratoconjunctivitis sicca (HP:0001097)1.80015360
153Alkalosis (HP:0001948)1.79313637
154Adrenal hypoplasia (HP:0000835)1.79234705
155Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79198361
156Fatigue (HP:0012378)1.79009077
157Abnormality of calcium-phosphate metabolism (HP:0100530)1.78725393
158Fibular aplasia (HP:0002990)1.78086217
159Leukodystrophy (HP:0002415)1.76884294
160Myocardial infarction (HP:0001658)1.76746697
161Lethargy (HP:0001254)1.76633339
162Joint stiffness (HP:0001387)1.76603074
163Arthralgia (HP:0002829)1.76141424
164Cardiomegaly (HP:0001640)1.76089288
165Deep venous thrombosis (HP:0002625)1.75940995
166Episodic fever (HP:0001954)1.75605959
167Premature loss of primary teeth (HP:0006323)1.75559063
168Thrombocytosis (HP:0001894)1.75473532
169Hypophosphatemia (HP:0002148)1.75292586
170Autoimmune thrombocytopenia (HP:0001973)1.74606285
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.74594874
172Short tibia (HP:0005736)1.73747165
173Retinal dysplasia (HP:0007973)1.73617779
174Renal cortical cysts (HP:0000803)1.73416187
175Hyperaldosteronism (HP:0000859)1.73153059
176Tetany (HP:0001281)1.73119841
177Hyperventilation (HP:0002883)1.72978698
178Dynein arm defect of respiratory motile cilia (HP:0012255)1.70939367
179Absent/shortened dynein arms (HP:0200106)1.70939367
180Abnormality of the septum pellucidum (HP:0007375)1.70767907
181Aplasia of the musculature (HP:0100854)1.70728117
182Abnormality of renin-angiotensin system (HP:0000847)1.70468861
183Dicarboxylic aciduria (HP:0003215)1.70296559
184Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70296559
185Abnormality of methionine metabolism (HP:0010901)1.70052543
186Hyperlipoproteinemia (HP:0010980)1.69980870
187Abnormality of chloride homeostasis (HP:0011422)1.69766045
188Hyperactive renin-angiotensin system (HP:0000841)1.69110015
189Abnormality of glycine metabolism (HP:0010895)1.67898718
190Abnormality of serine family amino acid metabolism (HP:0010894)1.67898718
191Limb dystonia (HP:0002451)1.66455994
192Polyuria (HP:0000103)1.66298763
193Anomalous pulmonary venous return (HP:0010772)1.64429042
194Widely patent fontanelles and sutures (HP:0004492)1.64393070
195Hypoplastic pelvis (HP:0008839)1.63729767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.34752919
2CASK3.72755078
3MAP4K13.40381509
4STK393.19207942
5TRIB32.86676707
6INSRR2.84835585
7RIPK42.83629763
8OXSR12.80678469
9IRAK32.59128546
10MAP2K32.47437140
11IRAK22.36983441
12BLK2.35406543
13STK162.31520019
14IRAK42.30463083
15TYK22.19495638
16SIK12.16166135
17IRAK12.09128445
18TNK22.08059699
19TNIK2.07272057
20PKN12.04997095
21WNK42.03451725
22EPHB12.02717906
23PBK2.01293602
24NME21.94204040
25TBK11.88679062
26MAP3K111.87348915
27MUSK1.83222359
28PNCK1.77678493
29PRPF4B1.75375554
30SMG11.74853036
31MAPK151.72157621
32ADRBK21.70480121
33ICK1.70346412
34MKNK21.68491154
35MAP3K31.68235214
36NEK61.61712789
37ZAP701.58650168
38MAP3K141.52019408
39WNK31.51770759
40MAPKAPK51.47005175
41TAOK21.46246584
42AKT31.43418750
43MAP3K11.41411731
44BMPR1B1.39759784
45GRK11.36612138
46JAK31.33443422
47PRKD21.31086179
48TAOK11.31004697
49GRK71.30161461
50RIPK11.29614156
51ERBB41.29408184
52EPHA21.27824440
53BTK1.25994859
54BMPR21.23918421
55ZAK1.23714899
56GRK61.22782094
57EEF2K1.21787551
58MARK21.20019257
59KIT1.18760856
60CSK1.18176743
61CSF1R1.16780202
62MET1.16697139
63FGFR41.14757415
64PTK61.14446729
65SIK21.14273066
66FGR1.11376138
67SYK1.10909962
68CDC42BPA1.09483566
69STK38L1.08053845
70EPHA31.04410875
71BCR1.03658520
72MAP2K61.02331494
73PRKCE1.00136807
74MKNK10.99015219
75DYRK20.98157574
76PDPK10.97753783
77MST40.97711471
78PINK10.96967212
79CAMK2B0.96824078
80JAK10.96530811
81TESK20.95620342
82EIF2AK20.95584270
83TGFBR20.94944646
84CAMK2D0.94632522
85YES10.94343241
86MATK0.91899738
87HCK0.90835515
88SIK30.85290634
89CLK10.84772844
90NLK0.84622600
91TXK0.83658638
92MAPK120.82453816
93CSNK1G30.81910527
94MAP3K70.81586625
95PDK10.80815121
96MAPK110.79753042
97WNK10.78680691
98JAK20.78554484
99PLK40.78309190
100CAMK2G0.78110437
101CSNK1A1L0.76725727
102SGK2230.75766731
103SGK4940.75766731
104TRPM70.75745834
105MARK30.74994851
106CDK120.73967896
107CSNK1G10.73732039
108KSR20.73160350
109TESK10.72856477
110PKN20.70901612
111CAMK2A0.68700160
112NME10.67963639
113MAP3K130.67711162
114ITK0.66608584
115LCK0.66135424
116ROCK20.65549576
117DAPK20.65411730
118RPS6KL10.63513007
119RPS6KC10.63513007
120BMX0.62408026
121MARK10.62352896
122PIK3CG0.62065066
123DDR20.60679930
124RPS6KA20.60659956
125LRRK20.60364129
126CDK30.59351010
127MST1R0.59254561
128TIE10.57537027
129PRKD30.56015540
130IKBKB0.55077488
131TAOK30.54151682
132RPS6KA50.53966413
133STK100.50899986
134VRK10.50855403
135BCKDK0.50416995
136RPS6KA60.50197431
137CSNK1G20.50179471
138BRAF0.50087001
139ABL20.49950794
140IKBKE0.49660700
141PRKCQ0.48294762
142PRKG10.47343555
143PRKG20.46181489
144PIK3CA0.46166786
145PIM20.46080346
146STK380.45849560
147DYRK1B0.45666730
148ARAF0.45309070
149MAP2K20.44014282
150FGFR30.43776962
151HIPK20.42337581
152CDK40.41925583
153PRKACA0.41394445
154MAP3K80.39068215
155MOS0.38989601
156MAPKAPK20.37802474
157TEC0.37683001
158PRKAA20.37629942
159LYN0.37409489
160CSNK1A10.36963935
161PAK30.36658083
162PAK40.36567977
163LMTK20.36220891
164FGFR20.36164987
165FES0.35851626
166MYLK0.35823443
167RET0.35641591
168MAPK40.35045459
169EPHA40.34891444
170MTOR0.34581168
171CAMKK10.33967453
172MAPK70.33500830
173ADRBK10.32973031
174MAP3K60.32440527
175FER0.32361191
176GRK50.31185626
177SRPK10.29698772

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.38147834
2Steroid biosynthesis_Homo sapiens_hsa001003.31853980
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01747764
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.95644503
5Oxidative phosphorylation_Homo sapiens_hsa001902.69983369
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54143396
7Leishmaniasis_Homo sapiens_hsa051402.43509330
8Osteoclast differentiation_Homo sapiens_hsa043802.39100130
9Sulfur metabolism_Homo sapiens_hsa009202.33681994
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31589608
11Protein export_Homo sapiens_hsa030602.26653157
12Histidine metabolism_Homo sapiens_hsa003402.20777908
13Sphingolipid metabolism_Homo sapiens_hsa006002.18204560
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12344560
15B cell receptor signaling pathway_Homo sapiens_hsa046622.11580883
16Butanoate metabolism_Homo sapiens_hsa006502.02755237
17Ether lipid metabolism_Homo sapiens_hsa005652.02133306
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.96558616
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85991103
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84979965
21Parkinsons disease_Homo sapiens_hsa050121.81008520
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79627032
23Acute myeloid leukemia_Homo sapiens_hsa052211.79170388
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77085311
25Linoleic acid metabolism_Homo sapiens_hsa005911.77072679
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76246111
27Tuberculosis_Homo sapiens_hsa051521.75769457
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70714552
29Arachidonic acid metabolism_Homo sapiens_hsa005901.67797161
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.67545153
31Folate biosynthesis_Homo sapiens_hsa007901.63591985
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61612829
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.60122067
34Type I diabetes mellitus_Homo sapiens_hsa049401.60115035
35Other glycan degradation_Homo sapiens_hsa005111.59169796
36Peroxisome_Homo sapiens_hsa041461.58646168
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58002651
38Primary immunodeficiency_Homo sapiens_hsa053401.55077803
39Vitamin digestion and absorption_Homo sapiens_hsa049771.53160752
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51895866
41Alzheimers disease_Homo sapiens_hsa050101.51809848
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51432611
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.51075494
44Retinol metabolism_Homo sapiens_hsa008301.50555096
45Toxoplasmosis_Homo sapiens_hsa051451.47544922
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46564154
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46421084
48Arginine and proline metabolism_Homo sapiens_hsa003301.46181421
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45770001
50Antigen processing and presentation_Homo sapiens_hsa046121.40912761
51RNA polymerase_Homo sapiens_hsa030201.37510697
52TNF signaling pathway_Homo sapiens_hsa046681.37344765
53Influenza A_Homo sapiens_hsa051641.34974858
54Pertussis_Homo sapiens_hsa051331.30846172
55beta-Alanine metabolism_Homo sapiens_hsa004101.29902925
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26652368
57Tryptophan metabolism_Homo sapiens_hsa003801.23999657
58Propanoate metabolism_Homo sapiens_hsa006401.23579705
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23493771
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20535308
61Chemical carcinogenesis_Homo sapiens_hsa052041.19832832
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.19281872
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18023716
64Herpes simplex infection_Homo sapiens_hsa051681.16655432
65Viral myocarditis_Homo sapiens_hsa054161.14235356
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13321074
67Huntingtons disease_Homo sapiens_hsa050161.13096660
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11113099
69Tyrosine metabolism_Homo sapiens_hsa003501.11055144
70Glutathione metabolism_Homo sapiens_hsa004801.09918789
71VEGF signaling pathway_Homo sapiens_hsa043701.07927484
72Staphylococcus aureus infection_Homo sapiens_hsa051501.07171539
73Galactose metabolism_Homo sapiens_hsa000521.06864188
74Hepatitis C_Homo sapiens_hsa051601.02449058
75Chronic myeloid leukemia_Homo sapiens_hsa052201.01922284
76Fatty acid metabolism_Homo sapiens_hsa012121.01815040
77Collecting duct acid secretion_Homo sapiens_hsa049661.01596479
78Fructose and mannose metabolism_Homo sapiens_hsa000511.00290184
79NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00067644
80Measles_Homo sapiens_hsa051620.99498694
81Notch signaling pathway_Homo sapiens_hsa043300.99231719
82Regulation of autophagy_Homo sapiens_hsa041400.98935846
83Hepatitis B_Homo sapiens_hsa051610.96070931
84ABC transporters_Homo sapiens_hsa020100.95347667
85Vitamin B6 metabolism_Homo sapiens_hsa007500.95120296
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92476955
87Metabolic pathways_Homo sapiens_hsa011000.92225293
88T cell receptor signaling pathway_Homo sapiens_hsa046600.92152833
89Complement and coagulation cascades_Homo sapiens_hsa046100.91964180
90Chemokine signaling pathway_Homo sapiens_hsa040620.91700980
91Rheumatoid arthritis_Homo sapiens_hsa053230.91530365
92Non-small cell lung cancer_Homo sapiens_hsa052230.87709115
93Pentose phosphate pathway_Homo sapiens_hsa000300.87367231
94Prion diseases_Homo sapiens_hsa050200.87319812
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86108735
96Fatty acid degradation_Homo sapiens_hsa000710.83903772
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83529590
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.83499209
99Apoptosis_Homo sapiens_hsa042100.83314882
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82899277
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81989356
102Pancreatic cancer_Homo sapiens_hsa052120.80189690
103Lysosome_Homo sapiens_hsa041420.78817590
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.78247299
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77867251
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77611715
107Serotonergic synapse_Homo sapiens_hsa047260.76518680
108African trypanosomiasis_Homo sapiens_hsa051430.76507269
109Phenylalanine metabolism_Homo sapiens_hsa003600.76441374
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.76182171
111Bladder cancer_Homo sapiens_hsa052190.75549739
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74868102
113Platelet activation_Homo sapiens_hsa046110.73501868
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.72895040
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72502305
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.71262103
117Autoimmune thyroid disease_Homo sapiens_hsa053200.71197409
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70903001
119Salmonella infection_Homo sapiens_hsa051320.69486085
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68566748
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.68105910
122GnRH signaling pathway_Homo sapiens_hsa049120.65991877
123Taste transduction_Homo sapiens_hsa047420.65279432
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64042773
125Mineral absorption_Homo sapiens_hsa049780.62727216
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.62314484
127Endocytosis_Homo sapiens_hsa041440.60443873
128Legionellosis_Homo sapiens_hsa051340.60359360
129Prolactin signaling pathway_Homo sapiens_hsa049170.59760220
130PPAR signaling pathway_Homo sapiens_hsa033200.59615608
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59032493
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58891089
133Phototransduction_Homo sapiens_hsa047440.57823754
134Cardiac muscle contraction_Homo sapiens_hsa042600.56716751
135Insulin resistance_Homo sapiens_hsa049310.56231410
136Shigellosis_Homo sapiens_hsa051310.55965154
137Graft-versus-host disease_Homo sapiens_hsa053320.55606713
138Ovarian steroidogenesis_Homo sapiens_hsa049130.55154363
139Amoebiasis_Homo sapiens_hsa051460.53525349
140Epstein-Barr virus infection_Homo sapiens_hsa051690.52673742
141Renin-angiotensin system_Homo sapiens_hsa046140.52502978
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52256407
143HTLV-I infection_Homo sapiens_hsa051660.51963259
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51184571
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48642086
146Inositol phosphate metabolism_Homo sapiens_hsa005620.48628331
147Viral carcinogenesis_Homo sapiens_hsa052030.46672878
148Phagosome_Homo sapiens_hsa041450.46164765
149mTOR signaling pathway_Homo sapiens_hsa041500.45198646
150Proteasome_Homo sapiens_hsa030500.45112392
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44056304
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41859396
153Malaria_Homo sapiens_hsa051440.40831027
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40611452
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39713123
156Starch and sucrose metabolism_Homo sapiens_hsa005000.39660292
157Nicotine addiction_Homo sapiens_hsa050330.37181167
158Systemic lupus erythematosus_Homo sapiens_hsa053220.36700835
159Glycerolipid metabolism_Homo sapiens_hsa005610.36299981
160Renal cell carcinoma_Homo sapiens_hsa052110.35123447
161HIF-1 signaling pathway_Homo sapiens_hsa040660.34882703
162Axon guidance_Homo sapiens_hsa043600.34010805
163Fat digestion and absorption_Homo sapiens_hsa049750.33862032
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.32376347
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.32326185
166Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32200856
167Allograft rejection_Homo sapiens_hsa053300.30888900
168Pyruvate metabolism_Homo sapiens_hsa006200.30345392
169Drug metabolism - other enzymes_Homo sapiens_hsa009830.29212263
170Sulfur relay system_Homo sapiens_hsa041220.28138252
171Vibrio cholerae infection_Homo sapiens_hsa051100.28013733
172Purine metabolism_Homo sapiens_hsa002300.23936264
173Hematopoietic cell lineage_Homo sapiens_hsa046400.22382943
174Asthma_Homo sapiens_hsa053100.20708305
175Non-homologous end-joining_Homo sapiens_hsa034500.20070950

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