GHITM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.87401501
2NADH metabolic process (GO:0006734)5.81367043
3tricarboxylic acid cycle (GO:0006099)5.63288566
4succinate metabolic process (GO:0006105)5.22839169
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.86165358
6regulation of cellular amino acid metabolic process (GO:0006521)4.76066186
7oxaloacetate metabolic process (GO:0006107)4.68821034
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.64366712
9regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.58506459
10negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.46916964
11negative regulation of ligase activity (GO:0051352)4.46916964
12regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.36784000
13regulation of acyl-CoA biosynthetic process (GO:0050812)4.34696323
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.34557995
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.27093110
16cullin deneddylation (GO:0010388)4.25828934
17synaptic vesicle exocytosis (GO:0016079)4.23208419
18signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.20079986
19intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.20079986
20regulation of coenzyme metabolic process (GO:0051196)4.16644628
21regulation of cofactor metabolic process (GO:0051193)4.16644628
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.16056697
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.16056697
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.16056697
25positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.15880818
26ribosome assembly (GO:0042255)4.13432259
27protein deneddylation (GO:0000338)4.11811232
28signal transduction involved in DNA damage checkpoint (GO:0072422)4.04866118
29signal transduction involved in DNA integrity checkpoint (GO:0072401)4.04866118
30Golgi transport vesicle coating (GO:0048200)4.02339941
31COPI coating of Golgi vesicle (GO:0048205)4.02339941
32glutamate secretion (GO:0014047)3.98223072
33positive regulation of ligase activity (GO:0051351)3.97992243
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.96882398
35neuronal action potential propagation (GO:0019227)3.96478540
36regulation of ubiquitin-protein transferase activity (GO:0051438)3.76659700
37ATP hydrolysis coupled proton transport (GO:0015991)3.75765387
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.75765387
39tRNA aminoacylation for protein translation (GO:0006418)3.75497909
40regulation of synaptic vesicle exocytosis (GO:2000300)3.67147969
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.66570882
42amino acid activation (GO:0043038)3.66069035
43tRNA aminoacylation (GO:0043039)3.66069035
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.63660821
45regulation of ligase activity (GO:0051340)3.63278816
46regulation of cellular amine metabolic process (GO:0033238)3.62972636
47neurotransmitter secretion (GO:0007269)3.61976971
48establishment of integrated proviral latency (GO:0075713)3.59285773
49regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55838593
50lysine metabolic process (GO:0006553)3.51771899
51lysine catabolic process (GO:0006554)3.51771899
52aspartate family amino acid catabolic process (GO:0009068)3.50753451
53synaptic vesicle maturation (GO:0016188)3.49574584
54dicarboxylic acid catabolic process (GO:0043649)3.48272440
55nucleobase-containing small molecule interconversion (GO:0015949)3.45908523
56vocalization behavior (GO:0071625)3.44699538
57protein maturation by protein folding (GO:0022417)3.41885907
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39833666
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.39631120
60deoxyribonucleotide biosynthetic process (GO:0009263)3.38718907
61formation of translation preinitiation complex (GO:0001731)3.37963731
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33331874
63regulation of synaptic vesicle transport (GO:1902803)3.31017234
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30871138
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28675281
66respiratory electron transport chain (GO:0022904)3.27018842
67transferrin transport (GO:0033572)3.24863989
68gamma-aminobutyric acid transport (GO:0015812)3.23688188
69regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22712854
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18163676
71electron transport chain (GO:0022900)3.17280535
72regulation of mitochondrial translation (GO:0070129)3.14742417
73positive regulation of cell cycle arrest (GO:0071158)3.14235674
742-deoxyribonucleotide biosynthetic process (GO:0009265)3.13416568
75deoxyribose phosphate biosynthetic process (GO:0046385)3.13416568
76regulation of sulfur metabolic process (GO:0042762)3.11364580
77ferric iron transport (GO:0015682)3.11143479
78trivalent inorganic cation transport (GO:0072512)3.11143479
792-oxoglutarate metabolic process (GO:0006103)3.10337949
80protein targeting to mitochondrion (GO:0006626)3.10045219
81striatum development (GO:0021756)3.09774812
82gluconeogenesis (GO:0006094)3.09016698
83negative regulation of protein ubiquitination (GO:0031397)3.08555637
84chaperone-mediated protein transport (GO:0072321)3.06244061
85DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01092500
86neurotransmitter-gated ion channel clustering (GO:0072578)3.00043936
87negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.99160269
88aerobic respiration (GO:0009060)2.98363729
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98098418
90establishment of viral latency (GO:0019043)2.96715576
91positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96083805
92neuromuscular process controlling posture (GO:0050884)2.95883309
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.94523409
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94096913
95dicarboxylic acid biosynthetic process (GO:0043650)2.92883130
96hexose biosynthetic process (GO:0019319)2.92310739
97activation of protein kinase A activity (GO:0034199)2.91771234
98locomotory exploration behavior (GO:0035641)2.91541446
99cellular potassium ion homeostasis (GO:0030007)2.91522223
100ATP synthesis coupled proton transport (GO:0015986)2.91408417
101energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91408417
102neuron-neuron synaptic transmission (GO:0007270)2.91394938
103protein localization to mitochondrion (GO:0070585)2.90432277
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90325322
105regulation of glutamate receptor signaling pathway (GO:1900449)2.90179104
106neurotransmitter transport (GO:0006836)2.89651695
107ribonucleoprotein complex disassembly (GO:0032988)2.89444969
108positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89390194
109pteridine-containing compound biosynthetic process (GO:0042559)2.89267015
110de novo protein folding (GO:0006458)2.86423856
111antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.86333539
112glutamate metabolic process (GO:0006536)2.82639711
113proline transport (GO:0015824)2.82596570
114regulation of cellular respiration (GO:0043457)2.81641248
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.81571336
116establishment of protein localization to mitochondrion (GO:0072655)2.81324792
117regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80697478
118IMP biosynthetic process (GO:0006188)2.80635119
119cellular respiration (GO:0045333)2.80489926
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79394558
121behavioral response to cocaine (GO:0048148)2.79360996
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.78920973
123de novo posttranslational protein folding (GO:0051084)2.77892749
124purine nucleobase biosynthetic process (GO:0009113)2.77241671
125L-methionine salvage (GO:0071267)2.76885244
126L-methionine biosynthetic process (GO:0071265)2.76885244
127amino acid salvage (GO:0043102)2.76885244
128regulation of neurotransmitter levels (GO:0001505)2.76785927
129cell cycle G1/S phase transition (GO:0044843)2.76670277
130G1/S transition of mitotic cell cycle (GO:0000082)2.76670277
131cellular ketone body metabolic process (GO:0046950)2.75639250
132negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.74745414
133negative regulation of cell cycle G1/S phase transition (GO:1902807)2.74745414
134respiratory chain complex IV assembly (GO:0008535)2.72163620
135branched-chain amino acid catabolic process (GO:0009083)2.71612706
136oxidative phosphorylation (GO:0006119)2.71577681
137positive regulation of protein ubiquitination (GO:0031398)2.69924659
138glycolytic process (GO:0006096)2.69754602
139IMP metabolic process (GO:0046040)2.69646306
140inner mitochondrial membrane organization (GO:0007007)2.68409454
141regulation of synapse structural plasticity (GO:0051823)2.68254950
142purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.67854557
143purine nucleoside monophosphate biosynthetic process (GO:0009127)2.67854557
144monosaccharide biosynthetic process (GO:0046364)2.67668211
145NAD metabolic process (GO:0019674)2.67187676
146mitochondrial transport (GO:0006839)2.67183110
147positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65908299
148signal transduction in response to DNA damage (GO:0042770)2.65406500
149organelle disassembly (GO:1903008)2.64743837
150tricarboxylic acid metabolic process (GO:0072350)2.62163721
151regulation of cell communication by electrical coupling (GO:0010649)2.58464424
152protein localization to synapse (GO:0035418)2.56084674
153regulation of sodium ion transmembrane transporter activity (GO:2000649)2.55935106
154long-term synaptic potentiation (GO:0060291)2.55280213
155regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53459225
156regulation of voltage-gated calcium channel activity (GO:1901385)2.51590716
157acetyl-CoA metabolic process (GO:0006084)2.50166228
158female mating behavior (GO:0060180)2.49808150
159negative regulation of dendrite morphogenesis (GO:0050774)2.49778067
160negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48831342
161sodium ion export (GO:0071436)2.48120489
162regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46967982
163synaptic transmission, glutamatergic (GO:0035249)2.46674009
164fatty acid beta-oxidation (GO:0006635)2.46034369
165regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.45403829
166regulation of female receptivity (GO:0045924)2.44949358
167ionotropic glutamate receptor signaling pathway (GO:0035235)2.44294108
168branched-chain amino acid metabolic process (GO:0009081)2.43709344
169cell communication by electrical coupling (GO:0010644)2.43629617
170regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.43487961
171regulation of neuronal synaptic plasticity (GO:0048168)2.40676922
172regulation of glutamate secretion (GO:0014048)2.40215029
173mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.40153542
174detection of calcium ion (GO:0005513)2.40070374
175regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.39988556
176thioester biosynthetic process (GO:0035384)2.39940960
177acyl-CoA biosynthetic process (GO:0071616)2.39940960
178neuron cell-cell adhesion (GO:0007158)2.37580053
179short-chain fatty acid metabolic process (GO:0046459)2.36122518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.31289298
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.16560739
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.09965978
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.85658044
5E2F7_22180533_ChIP-Seq_HELA_Human3.83938844
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.81319599
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80014204
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.78765637
9* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.71694011
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69496704
11EZH2_22144423_ChIP-Seq_EOC_Human3.60521379
12* EST1_17652178_ChIP-ChIP_JURKAT_Human3.53756091
13GBX2_23144817_ChIP-Seq_PC3_Human3.53610614
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.41154520
15ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14457776
16* ETS1_20019798_ChIP-Seq_JURKAT_Human3.11450152
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.10742806
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.02491593
19DCP1A_22483619_ChIP-Seq_HELA_Human2.73533064
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69114847
21TAF15_26573619_Chip-Seq_HEK293_Human2.69000018
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63926847
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62976372
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53692460
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52254171
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.50975356
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.45187407
28* ELK1_19687146_ChIP-ChIP_HELA_Human2.42122258
29VDR_23849224_ChIP-Seq_CD4+_Human2.40399130
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40296627
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38546472
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35650312
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34975025
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28887351
35RARB_27405468_Chip-Seq_BRAIN_Mouse2.27400818
36* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25333919
37* REST_21632747_ChIP-Seq_MESCs_Mouse2.23200688
38MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16450378
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16417048
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15224006
41FOXP3_21729870_ChIP-Seq_TREG_Human2.11946241
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04676588
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01836183
44MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01470534
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99688271
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99323271
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99094974
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98093720
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97411380
50* GABP_19822575_ChIP-Seq_HepG2_Human1.95244638
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94450762
52XRN2_22483619_ChIP-Seq_HELA_Human1.90558157
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.88082933
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85958016
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85958016
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85804775
57AR_21909140_ChIP-Seq_LNCAP_Human1.84657120
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.83789724
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80053959
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78365279
61* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77842919
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77730664
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76739342
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73532640
65SMAD4_21799915_ChIP-Seq_A2780_Human1.73489714
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73438983
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72761529
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68402051
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67207361
70* TTF2_22483619_ChIP-Seq_HELA_Human1.65115320
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62061594
72DROSHA_22980978_ChIP-Seq_HELA_Human1.58263072
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57697115
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55601560
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55248307
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.54358398
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54319637
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53318340
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52634691
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51235734
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50776281
82TFEB_21752829_ChIP-Seq_HELA_Human1.47683982
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.46721291
84* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44778058
85* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44507039
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.42370860
87VDR_22108803_ChIP-Seq_LS180_Human1.41561025
88* P300_19829295_ChIP-Seq_ESCs_Human1.41286562
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39914874
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39500621
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.39305908
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38841590
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38468798
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38074177
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38074177
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.35159781
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34168093
98AR_25329375_ChIP-Seq_VCAP_Human1.33427382
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32029661
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31671020
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.29797568
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29660699
103HTT_18923047_ChIP-ChIP_STHdh_Human1.27308163
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26084992
105ER_23166858_ChIP-Seq_MCF-7_Human1.25991257
106AR_21572438_ChIP-Seq_LNCaP_Human1.25802808
107* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25583549
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25434456
109EZH2_27304074_Chip-Seq_ESCs_Mouse1.23885312
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23669990
111* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23102656
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22934914
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21210029
114* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20838598
115KDM5A_27292631_Chip-Seq_BREAST_Human1.20589498
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.18057639
117ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17934546
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17619640
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16429809
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16342219
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.16004044
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15616980
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09224207
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08988996
125CBP_20019798_ChIP-Seq_JUKART_Human1.08958209
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08958209
127ELK1_22589737_ChIP-Seq_MCF10A_Human1.08176263
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08145278
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.07811227
130STAT3_23295773_ChIP-Seq_U87_Human1.06098842
131JUN_21703547_ChIP-Seq_K562_Human1.05597910
132SOX17_20123909_ChIP-Seq_XEN_Mouse1.04888227
133STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04522181
134* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02841241
135DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02390987
136ESR1_20079471_ChIP-ChIP_T-47D_Human1.02364656
137IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01643587
138TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00868786
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00366119
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99894507
141* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99726048
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.99295248
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.98781187
144MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98750520
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98589733
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98570795
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98501764
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98320807
149ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97962698
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.97149473
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96790693
152* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96168744
153ZNF274_21170338_ChIP-Seq_K562_Hela0.96105750
154* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95120878
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94471346
156FOXM1_23109430_ChIP-Seq_U2OS_Human0.94146261
157RXR_22108803_ChIP-Seq_LS180_Human0.93132086
158NANOG_19829295_ChIP-Seq_ESCs_Human0.92193219
159SOX2_19829295_ChIP-Seq_ESCs_Human0.92193219
160* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92095813
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.91407350
162TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90586038
163TCF4_23295773_ChIP-Seq_U87_Human0.89723546
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89316499
165ZNF263_19887448_ChIP-Seq_K562_Human0.88886060
166KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88126613
167* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87922516
168* BCAT_22108803_ChIP-Seq_LS180_Human0.87302163
169DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87127250
170MYC_18940864_ChIP-ChIP_HL60_Human0.86438398
171GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85979003
172KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85972730
173ELF5_23300383_ChIP-Seq_T47D_Human0.85939475
174TCF4_22108803_ChIP-Seq_LS180_Human0.85580970
175RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84885657
176CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84704189
177EOMES_21245162_ChIP-Seq_HESCs_Human0.84205093
178AR_19668381_ChIP-Seq_PC3_Human0.83324477
179SMAD_19615063_ChIP-ChIP_OVARY_Human0.82908871
180ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81981170
181TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80694724
182CLOCK_20551151_ChIP-Seq_293T_Human0.80659549
183CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80546108
184CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79945478
185RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79498705
186TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.76300350
187SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74539243
188DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74236410
189SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72069193
190EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70859470
191* CIITA_25753668_ChIP-Seq_RAJI_Human0.70241988
192SALL4_22934838_ChIP-ChIP_CD34+_Human0.70053335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.04457259
2MP0003880_abnormal_central_pattern3.54056779
3MP0002837_dystrophic_cardiac_calcinosis3.16469386
4MP0002822_catalepsy3.13378667
5MP0008058_abnormal_DNA_repair3.08182593
6MP0009046_muscle_twitch3.01692046
7MP0004957_abnormal_blastocyst_morpholog3.01683005
8MP0003186_abnormal_redox_activity2.93845932
9MP0003635_abnormal_synaptic_transmissio2.88132286
10MP0003693_abnormal_embryo_hatching2.87454322
11MP0003646_muscle_fatigue2.72732465
12MP0010234_abnormal_vibrissa_follicle2.71570816
13MP0009745_abnormal_behavioral_response2.69978507
14MP0002064_seizures2.68395652
15MP0000372_irregular_coat_pigmentation2.46776324
16MP0010094_abnormal_chromosome_stability2.43203788
17MP0001968_abnormal_touch/_nociception2.42416281
18MP0004270_analgesia2.41436451
19MP0003786_premature_aging2.27338218
20MP0002063_abnormal_learning/memory/cond2.26818253
21MP0002736_abnormal_nociception_after2.21974088
22MP0008007_abnormal_cellular_replicative2.20706050
23MP0002272_abnormal_nervous_system2.17498362
24MP0009697_abnormal_copulation2.14392010
25MP0002139_abnormal_hepatobiliary_system2.13473859
26MP0005451_abnormal_body_composition2.11880221
27MP0003111_abnormal_nucleus_morphology2.11844052
28MP0004130_abnormal_muscle_cell2.09434058
29MP0000751_myopathy2.08672104
30MP0004043_abnormal_pH_regulation2.05870880
31MP0003329_amyloid_beta_deposits2.03100498
32MP0006036_abnormal_mitochondrial_physio2.00272486
33MP0005408_hypopigmentation1.98527490
34MP0002735_abnormal_chemical_nociception1.94857086
35MP0005360_urolithiasis1.92269408
36MP0000013_abnormal_adipose_tissue1.89317420
37MP0002734_abnormal_mechanical_nocicepti1.87612334
38MP0002572_abnormal_emotion/affect_behav1.87544011
39MP0001501_abnormal_sleep_pattern1.82512948
40MP0002909_abnormal_adrenal_gland1.81570913
41MP0004215_abnormal_myocardial_fiber1.79793252
42MP0004036_abnormal_muscle_relaxation1.79430565
43MP0003195_calcinosis1.79088182
44MP0002877_abnormal_melanocyte_morpholog1.78455123
45MP0003077_abnormal_cell_cycle1.77947167
46MP0003718_maternal_effect1.77900300
47MP0001440_abnormal_grooming_behavior1.77378325
48MP0008932_abnormal_embryonic_tissue1.73178202
49MP0002876_abnormal_thyroid_physiology1.71313017
50MP0005085_abnormal_gallbladder_physiolo1.70841177
51MP0003806_abnormal_nucleotide_metabolis1.66837423
52MP0002067_abnormal_sensory_capabilities1.66173223
53MP0006035_abnormal_mitochondrial_morpho1.65826747
54MP0004084_abnormal_cardiac_muscle1.62177542
55MP0005332_abnormal_amino_acid1.61784192
56MP0005535_abnormal_body_temperature1.61256148
57MP0001486_abnormal_startle_reflex1.59839436
58MP0001727_abnormal_embryo_implantation1.58617766
59MP0008875_abnormal_xenobiotic_pharmacok1.57629833
60MP0004924_abnormal_behavior1.56075739
61MP0005386_behavior/neurological_phenoty1.56075739
62MP0000358_abnormal_cell_content/1.55810355
63MP0005636_abnormal_mineral_homeostasis1.51560607
64MP0004147_increased_porphyrin_level1.46229546
65MP0000749_muscle_degeneration1.42264774
66MP0001529_abnormal_vocalization1.42177599
67MP0004142_abnormal_muscle_tone1.41219293
68MP0001970_abnormal_pain_threshold1.41078390
69MP0009780_abnormal_chondrocyte_physiolo1.39770483
70MP0002733_abnormal_thermal_nociception1.38562797
71MP0008569_lethality_at_weaning1.37113607
72MP0010329_abnormal_lipoprotein_level1.35770968
73MP0006276_abnormal_autonomic_nervous1.33210863
74MP0005584_abnormal_enzyme/coenzyme_acti1.33135431
75MP0008872_abnormal_physiological_respon1.32015930
76MP0005365_abnormal_bile_salt1.31769987
77MP0005165_increased_susceptibility_to1.30204478
78MP0004484_altered_response_of1.27905378
79MP0003879_abnormal_hair_cell1.27263626
80MP0000604_amyloidosis1.27128097
81MP0001730_embryonic_growth_arrest1.25378922
82MP0004233_abnormal_muscle_weight1.24153704
83MP0005646_abnormal_pituitary_gland1.22503003
84MP0001661_extended_life_span1.20579564
85MP0002102_abnormal_ear_morphology1.18194999
86MP0005620_abnormal_muscle_contractility1.18110907
87MP0000747_muscle_weakness1.17198328
88MP0005330_cardiomyopathy1.16892838
89MP0003633_abnormal_nervous_system1.15753736
90MP0001984_abnormal_olfaction1.14829708
91MP0002972_abnormal_cardiac_muscle1.13816076
92MP0004145_abnormal_muscle_electrophysio1.13350255
93MP0002066_abnormal_motor_capabilities/c1.11947615
94MP0005075_abnormal_melanosome_morpholog1.11338374
95MP0002332_abnormal_exercise_endurance1.11262770
96MP0005058_abnormal_lysosome_morphology1.07580226
97MP0001905_abnormal_dopamine_level1.03354830
98MP0002118_abnormal_lipid_homeostasis1.02487505
99MP0003690_abnormal_glial_cell1.00714703
100MP0003011_delayed_dark_adaptation1.00165891
101MP0003631_nervous_system_phenotype0.98837869
102MP0004085_abnormal_heartbeat0.98161928
103MP0002269_muscular_atrophy0.97971393
104MP0004811_abnormal_neuron_physiology0.96319185
105MP0004858_abnormal_nervous_system0.95825654
106MP0008775_abnormal_heart_ventricle0.95715594
107MP0005501_abnormal_skin_physiology0.95249586
108MP0008874_decreased_physiological_sensi0.93180695
109MP0002229_neurodegeneration0.91430880
110MP0001765_abnormal_ion_homeostasis0.91322249
111MP0002090_abnormal_vision0.91175273
112MP0001853_heart_inflammation0.90478224
113MP0001666_abnormal_nutrient_absorption0.89928674
114MP0002971_abnormal_brown_adipose0.89232259
115MP0002078_abnormal_glucose_homeostasis0.88333936
116MP0005319_abnormal_enzyme/_coenzyme0.88248952
117MP0004087_abnormal_muscle_fiber0.87976023
118MP0003656_abnormal_erythrocyte_physiolo0.87805266
119MP0000343_altered_response_to0.86798949
120MP0008873_increased_physiological_sensi0.86679267
121MP0000313_abnormal_cell_death0.86527169
122MP0003221_abnormal_cardiomyocyte_apopto0.85533309
123MP0000230_abnormal_systemic_arterial0.85274078
124MP0004782_abnormal_surfactant_physiolog0.84951850
125MP0001881_abnormal_mammary_gland0.84734943
126MP0005670_abnormal_white_adipose0.84375255
127MP0002106_abnormal_muscle_physiology0.82951365
128MP0008260_abnormal_autophagy0.81675722
129MP0003137_abnormal_impulse_conducting0.81091633
130MP0003191_abnormal_cellular_cholesterol0.80869041
131MP0002184_abnormal_innervation0.80217093
132MP0002796_impaired_skin_barrier0.79986873
133MP0002557_abnormal_social/conspecific_i0.79636029
134MP0002080_prenatal_lethality0.78563738
135MP0006138_congestive_heart_failure0.78553591
136MP0005266_abnormal_metabolism0.77951860
137MP0002069_abnormal_eating/drinking_beha0.77390577
138MP0000609_abnormal_liver_physiology0.76694842
139MP0000350_abnormal_cell_proliferation0.76573760
140MP0005083_abnormal_biliary_tract0.76335683
141MP0005666_abnormal_adipose_tissue0.74124011
142MP0001764_abnormal_homeostasis0.73731708
143MP0001544_abnormal_cardiovascular_syste0.73625595
144MP0005385_cardiovascular_system_phenoty0.73625595
145MP0009643_abnormal_urine_homeostasis0.69503359
146MP0001697_abnormal_embryo_size0.66456778
147MP0009333_abnormal_splenocyte_physiolog0.66317625
148MP0003941_abnormal_skin_development0.60493567
149MP0005376_homeostasis/metabolism_phenot0.59597372
150MP0005253_abnormal_eye_physiology0.59440818
151MP0005166_decreased_susceptibility_to0.58734995
152MP0006072_abnormal_retinal_apoptosis0.56839496
153MP0005384_cellular_phenotype0.56694264
154MP0003950_abnormal_plasma_membrane0.56669564
155MP0002019_abnormal_tumor_incidence0.55460093
156MP0001929_abnormal_gametogenesis0.55292878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.28913810
2Pheochromocytoma (HP:0002666)4.12941465
3Neuroendocrine neoplasm (HP:0100634)3.97032094
4Atonic seizures (HP:0010819)3.83799973
5Abnormal mitochondria in muscle tissue (HP:0008316)3.83731707
6Myokymia (HP:0002411)3.75817794
7Increased serum pyruvate (HP:0003542)3.70059968
8Abnormality of glycolysis (HP:0004366)3.70059968
9Acute necrotizing encephalopathy (HP:0006965)3.59974939
10Acute encephalopathy (HP:0006846)3.45255440
11Focal seizures (HP:0007359)3.33728961
12Degeneration of anterior horn cells (HP:0002398)3.29086348
13Abnormality of the anterior horn cell (HP:0006802)3.29086348
14Hepatic necrosis (HP:0002605)3.27521768
15Hyperventilation (HP:0002883)3.26369478
16Hepatocellular necrosis (HP:0001404)3.20376782
17Absence seizures (HP:0002121)3.19698634
18Progressive macrocephaly (HP:0004481)3.16576270
19Increased hepatocellular lipid droplets (HP:0006565)3.13965488
20Epileptic encephalopathy (HP:0200134)3.13095345
21Abnormality of alanine metabolism (HP:0010916)3.10947171
22Hyperalaninemia (HP:0003348)3.10947171
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10947171
24Cerebral edema (HP:0002181)3.03377621
25Exercise-induced myalgia (HP:0003738)3.02396969
26Myoglobinuria (HP:0002913)3.02215844
27Mitochondrial inheritance (HP:0001427)2.99468580
28Lipid accumulation in hepatocytes (HP:0006561)2.98556993
29Increased CSF lactate (HP:0002490)2.93059474
30Generalized tonic-clonic seizures (HP:0002069)2.89758402
31Dialeptic seizures (HP:0011146)2.89260535
32Visual hallucinations (HP:0002367)2.86294741
33Microvesicular hepatic steatosis (HP:0001414)2.84207079
34Febrile seizures (HP:0002373)2.84071622
35Exercise-induced muscle cramps (HP:0003710)2.76737323
36Oligomenorrhea (HP:0000876)2.75636495
37Gout (HP:0001997)2.73932659
38Lactic acidosis (HP:0003128)2.68560091
39Type I transferrin isoform profile (HP:0003642)2.66524144
40Abnormality of fatty-acid metabolism (HP:0004359)2.66387237
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63289774
42Ketoacidosis (HP:0001993)2.57941303
43Progressive inability to walk (HP:0002505)2.57331596
44Increased muscle lipid content (HP:0009058)2.55923512
45Hypokinesia (HP:0002375)2.53736296
46Resting tremor (HP:0002322)2.49092685
47Abnormality of methionine metabolism (HP:0010901)2.48771178
48Cholecystitis (HP:0001082)2.48520305
49Abnormal gallbladder physiology (HP:0012438)2.48520305
50Dysmetric saccades (HP:0000641)2.47244011
51Neoplasm of the peripheral nervous system (HP:0100007)2.45782799
52Cerebral hypomyelination (HP:0006808)2.40633817
53Renal Fanconi syndrome (HP:0001994)2.40161530
54Ketosis (HP:0001946)2.39193863
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38182403
56Hyperammonemia (HP:0001987)2.35956380
57Hyperglycinuria (HP:0003108)2.35656011
58Reduced antithrombin III activity (HP:0001976)2.35563058
59Increased intramyocellular lipid droplets (HP:0012240)2.34833002
60Nemaline bodies (HP:0003798)2.34390090
61Anxiety (HP:0000739)2.32281580
62Palpitations (HP:0001962)2.31606685
63Dysdiadochokinesis (HP:0002075)2.30951327
64Impaired social interactions (HP:0000735)2.30588064
65Abnormal social behavior (HP:0012433)2.30588064
66Cholelithiasis (HP:0001081)2.29714872
67Respiratory failure (HP:0002878)2.27507909
68Abnormal eating behavior (HP:0100738)2.27471979
69Lethargy (HP:0001254)2.27199757
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.26407232
71Ragged-red muscle fibers (HP:0003200)2.25803728
72Abnormality of glycine metabolism (HP:0010895)2.25556488
73Abnormality of serine family amino acid metabolism (HP:0010894)2.25556488
74Poor eye contact (HP:0000817)2.25091513
75Muscle fiber inclusion bodies (HP:0100299)2.23564887
76Cerebral hemorrhage (HP:0001342)2.22984209
77Nausea (HP:0002018)2.22199961
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20780247
79Aplastic anemia (HP:0001915)2.19793115
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17219602
81Abnormal protein N-linked glycosylation (HP:0012347)2.17219602
82Abnormal protein glycosylation (HP:0012346)2.17219602
83Abnormal glycosylation (HP:0012345)2.17219602
84Status epilepticus (HP:0002133)2.16077025
85Rhabdomyolysis (HP:0003201)2.16044863
86Abnormal gallbladder morphology (HP:0012437)2.15974929
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15194351
88Dicarboxylic aciduria (HP:0003215)2.15194351
893-Methylglutaconic aciduria (HP:0003535)2.15035639
90Muscle stiffness (HP:0003552)2.14699813
91Abnormality of serum amino acid levels (HP:0003112)2.11799214
92Impaired vibration sensation in the lower limbs (HP:0002166)2.11180820
93CNS demyelination (HP:0007305)2.09868646
94Exercise intolerance (HP:0003546)2.09580613
95Hypobetalipoproteinemia (HP:0003563)2.09259745
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08664936
97Sudden death (HP:0001699)2.08459491
98Hypoglycemic coma (HP:0001325)2.07094155
99Progressive cerebellar ataxia (HP:0002073)2.06948870
100Truncal ataxia (HP:0002078)2.06006161
101Gaze-evoked nystagmus (HP:0000640)2.05815739
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05661419
103Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05661419
104Conjunctival hamartoma (HP:0100780)2.03228791
105Increased purine levels (HP:0004368)2.03053721
106Hyperuricemia (HP:0002149)2.03053721
107Methylmalonic aciduria (HP:0012120)2.01889232
108Upper limb muscle weakness (HP:0003484)2.01431332
109Myotonia (HP:0002486)2.01342441
110Tongue fasciculations (HP:0001308)2.01211222
111Action tremor (HP:0002345)2.00806268
112Athetosis (HP:0002305)1.99344925
113Multiple enchondromatosis (HP:0005701)1.99123733
114Leukodystrophy (HP:0002415)1.98975120
115Sensorimotor neuropathy (HP:0007141)1.98883043
116Hyperglycinemia (HP:0002154)1.97923167
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97250426
118Metabolic acidosis (HP:0001942)1.94519378
119Depression (HP:0000716)1.93893097
120Increased serum lactate (HP:0002151)1.91503902
121Vomiting (HP:0002013)1.91387606
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88708721
123Hyperbilirubinemia (HP:0002904)1.88015897
124Hyperinsulinemic hypoglycemia (HP:0000825)1.86056268
125Scanning speech (HP:0002168)1.86043217
126Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85625590
127Progressive muscle weakness (HP:0003323)1.85432639
128Abnormality of the vocal cords (HP:0008777)1.84930012
129Abnormality of the gallbladder (HP:0005264)1.84757278
130Urinary urgency (HP:0000012)1.83846874
131Neoplasm of the adrenal gland (HP:0100631)1.83553093
132Emotional lability (HP:0000712)1.83019898
133Esophageal neoplasm (HP:0100751)1.81962669
134Dysmetria (HP:0001310)1.81764533
135Inability to walk (HP:0002540)1.81703779
136Generalized aminoaciduria (HP:0002909)1.81560936
137X-linked dominant inheritance (HP:0001423)1.80690683
138Methylmalonic acidemia (HP:0002912)1.79953321
139Neoplasm of head and neck (HP:0012288)1.79357758
140CNS hypomyelination (HP:0003429)1.78634778
141Abnormality of placental membranes (HP:0011409)1.78583107
142Amniotic constriction ring (HP:0009775)1.78583107
143Autoamputation (HP:0001218)1.77792259
144Spastic paraparesis (HP:0002313)1.77338419
145Posterior subcapsular cataract (HP:0007787)1.76918594
146Abnormality of the motor neurons (HP:0002450)1.76762005
147Abnormal neuron morphology (HP:0012757)1.76762005
148Delusions (HP:0000746)1.76084964
149Delayed CNS myelination (HP:0002188)1.75387011
150Muscular hypotonia of the trunk (HP:0008936)1.75096054
151Tetraparesis (HP:0002273)1.74724711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.85108838
2PDK43.44786359
3PDK33.44786359
4MAP3K123.41231693
5EIF2AK33.34879263
6MST43.29638868
7PBK3.14566791
8NTRK33.09223577
9SRPK12.80140422
10MAP3K42.74021059
11EPHA42.68104880
12NEK12.54130152
13MAP3K92.48992834
14MAP2K72.47016682
15MAP2K42.36068907
16TRIM282.35105023
17MINK12.33431200
18CASK2.31422069
19PDK22.27327405
20STK162.25472700
21OXSR12.18508751
22BCKDK2.17656636
23ARAF2.15882845
24DAPK21.92517904
25LMTK21.91036626
26NME21.84058638
27TTK1.74167587
28PINK11.66716742
29TESK11.65332079
30CAMKK21.65127878
31PLK21.60020001
32KSR21.59314462
33ERBB31.56606039
34CDK191.55976712
35DAPK11.54346435
36VRK21.52922880
37PLK31.47317251
38NME11.46753118
39TSSK61.38767847
40PHKG21.38669573
41PHKG11.38669573
42WEE11.33763773
43TESK21.33678846
44WNK41.31572476
45NTRK11.30977300
46CAMKK11.30459087
47MAP4K21.26877313
48PAK61.24489788
49RIPK41.23243490
50SGK2231.20618767
51SGK4941.20618767
52PAK41.20412076
53GRK51.15706228
54PRKCG1.14425271
55MYLK1.13989454
56KSR11.10239028
57AKT31.08937750
58CDK51.06455313
59OBSCN1.03257759
60SIK31.02115426
61PRKD31.01755749
62CCNB11.01140608
63MST1R1.01101655
64BCR1.01092235
65CSNK1G31.00900514
66STK381.00827358
67STK390.95736201
68BRSK20.92627834
69WNK30.92446175
70CAMK2A0.92134784
71CLK10.90914164
72SGK20.90380076
73PDPK10.85954942
74CAMK2G0.85468838
75FER0.85352480
76MAPKAPK30.82758454
77MAP2K10.80131335
78CAMK2B0.79992891
79BRAF0.79592969
80PLK10.78575592
81PDK10.78016574
82MAP3K130.75543087
83CSNK1G20.74947791
84PTK2B0.73876480
85VRK10.73440844
86PAK30.72574500
87PRKCE0.72547135
88CAMK2D0.72044444
89SGK30.71617637
90CDK140.71116120
91PRPF4B0.70926423
92MAPKAPK50.69764039
93EIF2AK20.68443371
94CDK180.67904626
95PLK40.67833689
96SCYL20.66675853
97LIMK10.66084937
98CSNK1A1L0.66018521
99WNK10.65848127
100EIF2AK10.65813240
101ERBB40.63518208
102MAP2K60.63383060
103PRKCH0.63340894
104CDC70.62226447
105ALK0.61913520
106EPHA20.61701745
107DAPK30.61518228
108CSNK1G10.59486219
109PNCK0.59222960
110MAP3K20.59061972
111CDK150.58955265
112KDR0.58322446
113RET0.57060000
114RPS6KA40.56525939
115TRIB30.55264677
116LATS20.54886099
117BMPR20.54366260
118NTRK20.54295955
119BRSK10.52267180
120ZAK0.51059482
121AURKB0.50612552
122IRAK30.50001529
123PIM20.48478466
124ILK0.47781400
125AKT20.45321184
126ATR0.45320862
127SGK10.45233918
128FES0.45112397
129MAP3K10.44196833
130MARK10.44164957
131MAPK120.43989069
132CSNK2A20.43451831
133CDK11A0.43076740
134CSNK2A10.42689310
135RAF10.41872303
136PRKACA0.41238125
137MAP3K50.41050197
138PRKACG0.40333632
139ACVR1B0.39021580
140ROCK20.38845744
141ABL20.38251537
142PAK10.37886795
143CAMK10.36676623
144NUAK10.36187374
145TTN0.36001002
146NEK90.35569535
147NEK60.34528823
148STK100.33445579
149STK110.33304897
150STK40.32666719
151MAP3K80.32465805
152GRK70.32086722
153RPS6KA30.31283013
154PRKCA0.31096214
155TXK0.30324159

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.57579346
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40069155
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.32188069
4Synaptic vesicle cycle_Homo sapiens_hsa047212.79402103
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57608144
6Propanoate metabolism_Homo sapiens_hsa006402.53025219
7Collecting duct acid secretion_Homo sapiens_hsa049662.51004612
8Protein export_Homo sapiens_hsa030602.39178244
9Oxidative phosphorylation_Homo sapiens_hsa001902.34658949
10Pyruvate metabolism_Homo sapiens_hsa006202.33168513
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23681202
12Nicotine addiction_Homo sapiens_hsa050332.15676374
13Mismatch repair_Homo sapiens_hsa034302.03629243
14Carbon metabolism_Homo sapiens_hsa012002.01140999
15Butanoate metabolism_Homo sapiens_hsa006501.95849036
16Parkinsons disease_Homo sapiens_hsa050121.92984963
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92165833
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90019459
19DNA replication_Homo sapiens_hsa030301.76827272
20Fatty acid degradation_Homo sapiens_hsa000711.74593737
21GABAergic synapse_Homo sapiens_hsa047271.69870266
22Nitrogen metabolism_Homo sapiens_hsa009101.68647147
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68271067
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66949380
25Fatty acid metabolism_Homo sapiens_hsa012121.60292660
26Arginine biosynthesis_Homo sapiens_hsa002201.54012146
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52399204
28Alzheimers disease_Homo sapiens_hsa050101.47286488
29Cardiac muscle contraction_Homo sapiens_hsa042601.44813272
30Olfactory transduction_Homo sapiens_hsa047401.43709784
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40769705
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39364634
33Vibrio cholerae infection_Homo sapiens_hsa051101.38953753
34RNA polymerase_Homo sapiens_hsa030201.38279885
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36105700
36Biosynthesis of amino acids_Homo sapiens_hsa012301.34836720
37Morphine addiction_Homo sapiens_hsa050321.31810074
38One carbon pool by folate_Homo sapiens_hsa006701.31617559
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29920444
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28783269
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28131911
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26704886
43Long-term potentiation_Homo sapiens_hsa047201.26651025
44Folate biosynthesis_Homo sapiens_hsa007901.25516586
45Circadian entrainment_Homo sapiens_hsa047131.24506281
46Non-homologous end-joining_Homo sapiens_hsa034501.24185624
47Nucleotide excision repair_Homo sapiens_hsa034201.21579121
48Amphetamine addiction_Homo sapiens_hsa050311.21472725
49Fatty acid elongation_Homo sapiens_hsa000621.20033761
50Glutathione metabolism_Homo sapiens_hsa004801.16573500
51Pyrimidine metabolism_Homo sapiens_hsa002401.09104359
52RNA transport_Homo sapiens_hsa030131.08699535
53Dopaminergic synapse_Homo sapiens_hsa047281.07467213
54Spliceosome_Homo sapiens_hsa030401.05745645
55Salivary secretion_Homo sapiens_hsa049701.04300687
56Huntingtons disease_Homo sapiens_hsa050161.04075709
57PPAR signaling pathway_Homo sapiens_hsa033201.03430968
58Base excision repair_Homo sapiens_hsa034101.02323498
59Glutamatergic synapse_Homo sapiens_hsa047241.01913565
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.99978792
61Homologous recombination_Homo sapiens_hsa034400.99665404
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99298092
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.98749529
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95964257
65Gastric acid secretion_Homo sapiens_hsa049710.95820303
66beta-Alanine metabolism_Homo sapiens_hsa004100.95666207
67Peroxisome_Homo sapiens_hsa041460.91604422
68Insulin secretion_Homo sapiens_hsa049110.91128966
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87995315
70Ribosome_Homo sapiens_hsa030100.86376785
71Renin secretion_Homo sapiens_hsa049240.85765783
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85032859
73Tryptophan metabolism_Homo sapiens_hsa003800.84542653
74Vitamin B6 metabolism_Homo sapiens_hsa007500.84021736
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83054307
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80843566
77Fructose and mannose metabolism_Homo sapiens_hsa000510.80275885
78Taste transduction_Homo sapiens_hsa047420.80116461
79Phenylalanine metabolism_Homo sapiens_hsa003600.79500464
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79472288
81RNA degradation_Homo sapiens_hsa030180.79381439
82Purine metabolism_Homo sapiens_hsa002300.79129025
83Calcium signaling pathway_Homo sapiens_hsa040200.78695828
84Steroid biosynthesis_Homo sapiens_hsa001000.77221407
85Bile secretion_Homo sapiens_hsa049760.77104772
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74982240
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69834389
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.69073238
89Oxytocin signaling pathway_Homo sapiens_hsa049210.67979533
90Cholinergic synapse_Homo sapiens_hsa047250.67750903
91Glucagon signaling pathway_Homo sapiens_hsa049220.67616224
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65594813
93Galactose metabolism_Homo sapiens_hsa000520.64672212
94Oocyte meiosis_Homo sapiens_hsa041140.64250931
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62595043
96Long-term depression_Homo sapiens_hsa047300.60937706
97Regulation of autophagy_Homo sapiens_hsa041400.60138181
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58610299
99Type I diabetes mellitus_Homo sapiens_hsa049400.58275478
100Fatty acid biosynthesis_Homo sapiens_hsa000610.56335234
101Rheumatoid arthritis_Homo sapiens_hsa053230.56128192
102Serotonergic synapse_Homo sapiens_hsa047260.55394228
103Glycerolipid metabolism_Homo sapiens_hsa005610.54309538
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.53866263
105Basal transcription factors_Homo sapiens_hsa030220.53691610
106Cocaine addiction_Homo sapiens_hsa050300.53060558
107Sulfur metabolism_Homo sapiens_hsa009200.52674758
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52214431
109Fanconi anemia pathway_Homo sapiens_hsa034600.52189421
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50958725
111N-Glycan biosynthesis_Homo sapiens_hsa005100.50897229
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49789669
113Cell cycle_Homo sapiens_hsa041100.49331306
114Dilated cardiomyopathy_Homo sapiens_hsa054140.45899684
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43334801
116Tyrosine metabolism_Homo sapiens_hsa003500.43323281
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43285576
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43056072
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42211330
120Sulfur relay system_Homo sapiens_hsa041220.41922496
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41346469
122Proteasome_Homo sapiens_hsa030500.40592093
123Starch and sucrose metabolism_Homo sapiens_hsa005000.39945849
124Mineral absorption_Homo sapiens_hsa049780.39704312
125Pentose phosphate pathway_Homo sapiens_hsa000300.39692256
126Gap junction_Homo sapiens_hsa045400.38708363
127cAMP signaling pathway_Homo sapiens_hsa040240.37464004
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.36846003
129Thyroid hormone synthesis_Homo sapiens_hsa049180.36156848
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35875803
131Caffeine metabolism_Homo sapiens_hsa002320.35820350
132Metabolic pathways_Homo sapiens_hsa011000.34238954
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33898543
134Legionellosis_Homo sapiens_hsa051340.32294203
135Chemical carcinogenesis_Homo sapiens_hsa052040.31110464
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30461579
137Insulin signaling pathway_Homo sapiens_hsa049100.30365988
138Arginine and proline metabolism_Homo sapiens_hsa003300.29906878
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29454841
140GnRH signaling pathway_Homo sapiens_hsa049120.29209196
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28458577
142Phagosome_Homo sapiens_hsa041450.28361406
143Selenocompound metabolism_Homo sapiens_hsa004500.28073296
144Type II diabetes mellitus_Homo sapiens_hsa049300.27666040
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.27527136
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27288872
147Fat digestion and absorption_Homo sapiens_hsa049750.25237260
148Retinol metabolism_Homo sapiens_hsa008300.22698037
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.18505752
150mRNA surveillance pathway_Homo sapiens_hsa030150.16825614
151Epstein-Barr virus infection_Homo sapiens_hsa051690.16098190

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