GHRHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pericardium development (GO:0060039)9.63641633
2tongue development (GO:0043586)8.87570360
3positive regulation of receptor biosynthetic process (GO:0010870)8.01191704
4ventricular cardiac muscle cell development (GO:0055015)7.90893010
5activation of Rac GTPase activity (GO:0032863)7.82854813
6regulation of response to tumor cell (GO:0002834)7.60522221
7positive regulation of response to tumor cell (GO:0002836)7.60522221
8positive regulation of immune response to tumor cell (GO:0002839)7.60522221
9regulation of immune response to tumor cell (GO:0002837)7.60522221
10pharyngeal system development (GO:0060037)7.32418498
11activated T cell proliferation (GO:0050798)6.97971756
12negative regulation of erythrocyte differentiation (GO:0045647)6.87804983
13hypothalamus development (GO:0021854)6.86041827
14nitric oxide biosynthetic process (GO:0006809)6.76671097
15urea cycle (GO:0000050)6.65175006
16urea metabolic process (GO:0019627)6.65175006
17regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.32344058
18negative regulation of interleukin-10 production (GO:0032693)6.22673797
19embryonic heart tube development (GO:0035050)6.17227889
20nitrogen cycle metabolic process (GO:0071941)5.99731927
21regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.99665372
22regulation of Cdc42 GTPase activity (GO:0043088)5.74122931
23dendritic cell chemotaxis (GO:0002407)5.47914902
24cellular response to ATP (GO:0071318)5.46058461
25alkaloid metabolic process (GO:0009820)5.43838799
26arginine metabolic process (GO:0006525)5.30641133
27multicellular organism reproduction (GO:0032504)5.27134551
28dopamine biosynthetic process (GO:0042416)5.19101452
29glyoxylate metabolic process (GO:0046487)5.07369713
30regulation of dendritic cell antigen processing and presentation (GO:0002604)5.06814456
31retinal cone cell development (GO:0046549)5.01808757
32positive regulation of granulocyte chemotaxis (GO:0071624)4.99520455
33cilium or flagellum-dependent cell motility (GO:0001539)4.84016721
34behavioral response to nicotine (GO:0035095)4.82061878
35regulation of female gonad development (GO:2000194)4.79916157
36regulation of transforming growth factor beta2 production (GO:0032909)4.74842701
37germinal center formation (GO:0002467)4.63120828
38positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.62940685
39positive regulation of natural killer cell mediated immunity (GO:0002717)4.62940685
40sperm motility (GO:0030317)4.54962955
41serine family amino acid catabolic process (GO:0009071)4.54143471
42positive regulation of cell adhesion mediated by integrin (GO:0033630)4.51206009
43regulation of protein polyubiquitination (GO:1902914)4.50281690
44regulation of lipoprotein particle clearance (GO:0010984)4.49353337
45coenzyme catabolic process (GO:0009109)4.47769973
46DNA methylation involved in gamete generation (GO:0043046)4.42307312
47oxidative demethylation (GO:0070989)4.39343855
48acetyl-CoA metabolic process (GO:0006084)4.36491260
49glycine transport (GO:0015816)4.34061430
50oxygen transport (GO:0015671)4.26052614
51regulation of DNA methylation (GO:0044030)4.25871120
52head development (GO:0060322)4.24413096
53phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.23748471
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.22114156
55regulation of natural killer cell mediated immunity (GO:0002715)4.22114156
56regulation of receptor biosynthetic process (GO:0010869)4.18678436
57regulation of endothelial cell chemotaxis (GO:2001026)4.06042494
58endothelial cell chemotaxis (GO:0035767)4.03873024
59meiotic cell cycle (GO:0051321)3.97563638
60single strand break repair (GO:0000012)3.90303947
61regulation of acrosome reaction (GO:0060046)3.90119451
62glomerular visceral epithelial cell development (GO:0072015)3.81459868
63reproduction (GO:0000003)3.79908923
64dendritic cell migration (GO:0036336)3.79431504
65regulation of integrin activation (GO:0033623)3.76719555
66catechol-containing compound biosynthetic process (GO:0009713)3.74140909
67catecholamine biosynthetic process (GO:0042423)3.74140909
68regulation of dopamine secretion (GO:0014059)3.71512629
69positive regulation of T cell chemotaxis (GO:0010820)3.65424237
70regulation of T cell chemotaxis (GO:0010819)3.65424237
71mesenchymal-epithelial cell signaling (GO:0060638)3.57398363
72nonmotile primary cilium assembly (GO:0035058)3.54547547
73chaperone-mediated protein complex assembly (GO:0051131)3.54302874
74protein localization to kinetochore (GO:0034501)3.49310618
75regulation of G0 to G1 transition (GO:0070316)3.48844220
76positive regulation of gastrulation (GO:2000543)3.46132482
77T cell proliferation (GO:0042098)3.44108589
78male meiosis (GO:0007140)3.42053796
79microtubule depolymerization (GO:0007019)3.39860675
80protein import into peroxisome matrix (GO:0016558)3.36867333
81spermatid development (GO:0007286)3.36804040
82microtubule polymerization or depolymerization (GO:0031109)3.36513033
83positive regulation of monocyte chemotaxis (GO:0090026)3.35433470
84glomerular epithelial cell development (GO:0072310)3.34881601
85positive regulation of natural killer cell differentiation (GO:0032825)3.34856277
86cysteine metabolic process (GO:0006534)3.34745738
87DNA replication-dependent nucleosome organization (GO:0034723)3.33981916
88DNA replication-dependent nucleosome assembly (GO:0006335)3.33981916
89somite rostral/caudal axis specification (GO:0032525)3.33499266
90phenylpropanoid metabolic process (GO:0009698)3.28559175
91gas transport (GO:0015669)3.28026889
92positive regulation of neutrophil chemotaxis (GO:0090023)3.27488121
93positive regulation of neutrophil migration (GO:1902624)3.27488121
94drug catabolic process (GO:0042737)3.25128257
95positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.24940668
96NIK/NF-kappaB signaling (GO:0038061)3.23041951
97positive regulation of interleukin-4 production (GO:0032753)3.22307835
98piRNA metabolic process (GO:0034587)3.21937659
99positive regulation of antigen processing and presentation (GO:0002579)3.21212613
100axonemal dynein complex assembly (GO:0070286)3.20270144
101L-serine metabolic process (GO:0006563)3.20229678
102regulation of meiosis I (GO:0060631)3.18779486
103detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.18320834
104phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.17033365
105eyelid development in camera-type eye (GO:0061029)3.16749773
106histone-serine phosphorylation (GO:0035404)3.16598494
107chronic inflammatory response (GO:0002544)3.12539815
108T cell mediated immunity (GO:0002456)3.12537725
109biotin metabolic process (GO:0006768)3.11448290
110regulation of histone H3-K9 methylation (GO:0051570)3.10450312
111imidazole-containing compound metabolic process (GO:0052803)3.10294860
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.07035207
113leukocyte mediated cytotoxicity (GO:0001909)3.06279401
114sperm-egg recognition (GO:0035036)3.05754871
115regulation of granulocyte chemotaxis (GO:0071622)3.04876812
116phosphatidylserine acyl-chain remodeling (GO:0036150)3.03354815
117bile acid and bile salt transport (GO:0015721)3.02280878
118serine family amino acid metabolic process (GO:0009069)3.01661900
119regulation of female receptivity (GO:0045924)3.01372630
120single fertilization (GO:0007338)3.00517121
121protein polyglutamylation (GO:0018095)2.98220438
122activation of Ras GTPase activity (GO:0032856)2.98173426
123heart valve formation (GO:0003188)2.95664590
124transmission of nerve impulse (GO:0019226)2.93503867
125epithelial cell maturation (GO:0002070)2.93066045
126mitochondrion distribution (GO:0048311)2.92665179
127regulation of spindle checkpoint (GO:0090231)2.92525625
128hydrogen peroxide biosynthetic process (GO:0050665)2.91953278
129regulation of protein heterodimerization activity (GO:0043497)2.91551757
130phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.91535108
131neurotransmitter-gated ion channel clustering (GO:0072578)2.91235149
132cilium movement (GO:0003341)2.90977225
133respiratory tube development (GO:0030323)2.88955303
134regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86164804
135positive regulation of cell killing (GO:0031343)2.85987602
136phosphatidylinositol acyl-chain remodeling (GO:0036149)2.85216307
137binding of sperm to zona pellucida (GO:0007339)2.84706314
138cofactor catabolic process (GO:0051187)2.84152312
139regulation of hair follicle development (GO:0051797)2.83100875
140import into cell (GO:0098657)2.81896751
141dopamine metabolic process (GO:0042417)2.81313491
142cullin deneddylation (GO:0010388)2.79389850
143carnitine shuttle (GO:0006853)2.78812758
144gene silencing by RNA (GO:0031047)2.78590945
145microtubule severing (GO:0051013)2.78021922
146fertilization (GO:0009566)2.77848065
147regulation of catecholamine secretion (GO:0050433)2.77149251
148regulation of activation of Janus kinase activity (GO:0010533)2.75949867
149coenzyme A metabolic process (GO:0015936)2.75934168
150cellular response to thyroid hormone stimulus (GO:0097067)2.75791676
151activation of Rho GTPase activity (GO:0032862)2.74992131
152epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.74075369
153regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.74063747
154synaptic transmission, dopaminergic (GO:0001963)2.74047615
155SMAD protein complex assembly (GO:0007183)2.73755686
156glycine metabolic process (GO:0006544)2.72928154
157locomotory exploration behavior (GO:0035641)2.72296679
158nitric oxide metabolic process (GO:0046209)2.71274393
159fatty acid transmembrane transport (GO:1902001)2.71124880
160synapsis (GO:0007129)2.70545346
161regulation of cell maturation (GO:1903429)2.70442821
162positive regulation of prostaglandin secretion (GO:0032308)2.70386906
163regulation of actin nucleation (GO:0051125)2.70004208
164activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.68590918
165positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.68339605
166regulation of T-helper 1 cell differentiation (GO:0045625)2.68034158
167behavioral response to ethanol (GO:0048149)2.66186004
168bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65537506
169negative regulation of histone methylation (GO:0031061)2.65260396
170fatty acid elongation (GO:0030497)2.64191858
171digestive tract development (GO:0048565)2.62394735
172regulation of steroid hormone secretion (GO:2000831)2.62114823
173regulation of antigen processing and presentation (GO:0002577)2.60573021
174eye photoreceptor cell differentiation (GO:0001754)2.60016449
175photoreceptor cell differentiation (GO:0046530)2.60016449
176reactive oxygen species biosynthetic process (GO:1903409)2.59992644
177cardiac muscle cell development (GO:0055013)2.59161708
178positive regulation of T-helper 1 type immune response (GO:0002827)2.58894725
179male meiosis I (GO:0007141)2.58766978
180succinate metabolic process (GO:0006105)2.58566271
181histone exchange (GO:0043486)2.57784368
182positive regulation of interleukin-1 beta secretion (GO:0050718)2.57411391
183methionine metabolic process (GO:0006555)2.56456128
184epithelial cilium movement (GO:0003351)2.55773089
185meiotic nuclear division (GO:0007126)2.55473808
186sulfation (GO:0051923)2.55273315
187centriole replication (GO:0007099)2.54697106
188negative regulation of reproductive process (GO:2000242)2.54516666
189otic vesicle formation (GO:0030916)2.54390441
190phosphatidylcholine acyl-chain remodeling (GO:0036151)2.53685490
191basic amino acid transport (GO:0015802)2.52429958
192protein K48-linked deubiquitination (GO:0071108)2.51451016
193female mating behavior (GO:0060180)2.48661131
194cell-cell recognition (GO:0009988)2.48660291
195phenol-containing compound biosynthetic process (GO:0046189)2.48303175
196positive regulation of Cdc42 GTPase activity (GO:0043089)10.1111808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.98533973
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.64752659
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.16043929
4GBX2_23144817_ChIP-Seq_PC3_Human3.07080274
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06544617
6ZNF274_21170338_ChIP-Seq_K562_Hela2.93162508
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73354580
8EZH2_22144423_ChIP-Seq_EOC_Human2.65162354
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.62852922
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61362167
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53549270
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49009865
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48666425
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45532433
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.43552827
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41132818
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38903814
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38903814
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.21673016
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20541564
21* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15306234
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.14168950
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.10683746
24* DROSHA_22980978_ChIP-Seq_HELA_Human2.07965619
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02455296
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01577912
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98113348
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98084229
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97334052
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.93654514
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89546906
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.88444706
33VDR_22108803_ChIP-Seq_LS180_Human1.87820337
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83804849
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.81550514
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79601096
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79338284
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.75839211
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73070632
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72538239
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71412850
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70245220
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.69494872
44TP53_22573176_ChIP-Seq_HFKS_Human1.66616617
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64841111
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64673954
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.63052971
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.60955658
49GATA1_22025678_ChIP-Seq_K562_Human1.59544092
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59093823
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57722348
52RXR_22158963_ChIP-Seq_LIVER_Mouse1.54034445
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51484254
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50087726
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48817211
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48344310
57ERG_20517297_ChIP-Seq_VCAP_Human1.47298816
58AR_25329375_ChIP-Seq_VCAP_Human1.47168389
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46942030
60* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44530649
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.44141964
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43696709
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42861208
64RUNX2_22187159_ChIP-Seq_PCA_Human1.42393358
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42318725
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41863356
67OCT4_20526341_ChIP-Seq_ESCs_Human1.41778741
68VDR_24787735_ChIP-Seq_THP-1_Human1.40107661
69MYC_19829295_ChIP-Seq_ESCs_Human1.39673841
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36427663
71REST_21632747_ChIP-Seq_MESCs_Mouse1.36373579
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34210892
73CBP_20019798_ChIP-Seq_JUKART_Human1.34210892
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34181006
75STAT3_23295773_ChIP-Seq_U87_Human1.33257048
76TAF15_26573619_Chip-Seq_HEK293_Human1.33028846
77ERA_21632823_ChIP-Seq_H3396_Human1.33010711
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32009102
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32009102
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32009102
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31463924
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31244896
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28534826
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28156988
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28156988
86FUS_26573619_Chip-Seq_HEK293_Human1.25747141
87NANOG_20526341_ChIP-Seq_ESCs_Human1.24471275
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.23271330
89BCAT_22108803_ChIP-Seq_LS180_Human1.23138999
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20188587
91AR_21572438_ChIP-Seq_LNCaP_Human1.19658668
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19454835
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19042736
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18583503
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18564304
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.17672503
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.16377213
98SMAD4_21799915_ChIP-Seq_A2780_Human1.16258438
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.15079233
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14867225
101AR_20517297_ChIP-Seq_VCAP_Human1.13886083
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13853111
103P300_19829295_ChIP-Seq_ESCs_Human1.13443904
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.12753075
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.12666406
106FOXH1_21741376_ChIP-Seq_EPCs_Human1.12587669
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.12065712
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12065712
109WDR5_24793694_ChIP-Seq_LNCAP_Human1.11997273
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11316034
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08028597
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07758350
113PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07130293
114NCOR_22424771_ChIP-Seq_293T_Human1.06495768
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06340724
116SOX2_20726797_ChIP-Seq_SW620_Human1.05730356
117* TCF4_23295773_ChIP-Seq_U87_Human1.05528470
118OCT1_27270436_Chip-Seq_PROSTATE_Human1.05360076
119CBX2_27304074_Chip-Seq_ESCs_Mouse1.04875221
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04812173
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03668096
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03105091
123TCF4_22108803_ChIP-Seq_LS180_Human1.03005625
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.02903361
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.02083325
126CBP_21632823_ChIP-Seq_H3396_Human1.01935636
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01901825
128* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00877028
129SOX2_19829295_ChIP-Seq_ESCs_Human1.00601504
130NANOG_19829295_ChIP-Seq_ESCs_Human1.00601504
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99886913
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98820150
133PHF8_20622853_ChIP-Seq_HELA_Human0.97658455
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97268036
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.96501604
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95268522
137HOXB7_26014856_ChIP-Seq_BT474_Human0.95235718
138NFYB_21822215_ChIP-Seq_K562_Human0.95063133
139IRF1_19129219_ChIP-ChIP_H3396_Human0.94387718
140RAC3_21632823_ChIP-Seq_H3396_Human0.93665638
141RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93616879
142RXR_22108803_ChIP-Seq_LS180_Human0.92672980
143NFYA_21822215_ChIP-Seq_K562_Human0.91108135
144STAT1_17558387_ChIP-Seq_HELA_Human0.90530422
145CTCF_20526341_ChIP-Seq_ESCs_Human0.90398299
146TP53_16413492_ChIP-PET_HCT116_Human0.90193682
147IGF1R_20145208_ChIP-Seq_DFB_Human0.90029379
148NFE2_27457419_Chip-Seq_LIVER_Mouse0.89808164
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.89273959
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.89171936
151EWS_26573619_Chip-Seq_HEK293_Human0.88706596
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.87113076
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86829374
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85970663
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.85960724
156KDM2B_26808549_Chip-Seq_REH_Human0.85745637
157TP53_18474530_ChIP-ChIP_U2OS_Human0.85173392
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.84813633
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.84455843
160ER_23166858_ChIP-Seq_MCF-7_Human0.83698351
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83651268
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83177215
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.81433293
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81225662
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79949115
166OCT4_18555785_Chip-Seq_ESCs_Mouse0.79825594
167KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79749108
168WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78215161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat9.09441421
2MP0002876_abnormal_thyroid_physiology5.36120142
3MP0001346_abnormal_lacrimal_gland4.73399087
4MP0001348_abnormal_lacrimal_gland3.85905660
5MP0003718_maternal_effect3.83104372
6MP0005645_abnormal_hypothalamus_physiol3.81969208
7MP0008877_abnormal_DNA_methylation3.77153702
8MP0010352_gastrointestinal_tract_polyps3.64955458
9MP0002822_catalepsy3.54065564
10MP0002277_abnormal_respiratory_mucosa3.36313653
11MP0003183_abnormal_peptide_metabolism3.21576009
12MP0005410_abnormal_fertilization3.06354199
13MP0002653_abnormal_ependyma_morphology2.84347398
14MP0003705_abnormal_hypodermis_morpholog2.83797839
15MP0001835_abnormal_antigen_presentation2.75322346
16MP0002102_abnormal_ear_morphology2.65803551
17MP0004782_abnormal_surfactant_physiolog2.53549062
18MP0004270_analgesia2.45013471
19MP0008789_abnormal_olfactory_epithelium2.40750390
20MP0005551_abnormal_eye_electrophysiolog2.36760668
21MP0009697_abnormal_copulation2.35350558
22MP0000685_abnormal_immune_system2.08566089
23MP0005647_abnormal_sex_gland2.06826812
24MP0001873_stomach_inflammation2.00154924
25MP0005499_abnormal_olfactory_system1.97863192
26MP0005394_taste/olfaction_phenotype1.97863192
27MP0001529_abnormal_vocalization1.97725215
28MP0005167_abnormal_blood-brain_barrier1.89297760
29MP0005423_abnormal_somatic_nervous1.84289357
30MP0001929_abnormal_gametogenesis1.83457105
31MP0000003_abnormal_adipose_tissue1.78264349
32MP0002282_abnormal_trachea_morphology1.76961616
33MP0005395_other_phenotype1.70682298
34* MP0003698_abnormal_male_reproductive1.62513596
35MP0010030_abnormal_orbit_morphology1.59473557
36MP0005451_abnormal_body_composition1.58940944
37MP0006292_abnormal_olfactory_placode1.56677381
38MP0004510_myositis1.56639965
39MP0003890_abnormal_embryonic-extraembry1.50845980
40MP0008872_abnormal_physiological_respon1.49350236
41MP0010386_abnormal_urinary_bladder1.48453879
42MP0002210_abnormal_sex_determination1.47094848
43MP0000026_abnormal_inner_ear1.44880070
44MP0001177_atelectasis1.44153650
45MP0002909_abnormal_adrenal_gland1.43485228
46MP0003136_yellow_coat_color1.43168457
47MP0000538_abnormal_urinary_bladder1.43056505
48MP0009379_abnormal_foot_pigmentation1.42147370
49MP0008875_abnormal_xenobiotic_pharmacok1.40700951
50MP0003880_abnormal_central_pattern1.40683185
51MP0002734_abnormal_mechanical_nocicepti1.39626986
52MP0005365_abnormal_bile_salt1.38831982
53MP0005310_abnormal_salivary_gland1.38135120
54MP0003252_abnormal_bile_duct1.37568233
55MP0003868_abnormal_feces_composition1.36324428
56* MP0003959_abnormal_lean_body1.36010014
57MP0001485_abnormal_pinna_reflex1.33212275
58MP0001963_abnormal_hearing_physiology1.31554342
59MP0005332_abnormal_amino_acid1.28231188
60MP0003937_abnormal_limbs/digits/tail_de1.27830798
61MP0002234_abnormal_pharynx_morphology1.26761317
62MP0003195_calcinosis1.26704604
63MP0002736_abnormal_nociception_after1.25850922
64MP0003119_abnormal_digestive_system1.24992898
65MP0000653_abnormal_sex_gland1.22076182
66MP0006082_CNS_inflammation1.21652190
67* MP0002161_abnormal_fertility/fecundity1.21277154
68* MP0000631_abnormal_neuroendocrine_gland1.20488165
69MP0000566_synostosis1.18983604
70MP0005085_abnormal_gallbladder_physiolo1.16572140
71MP0006276_abnormal_autonomic_nervous1.16016078
72MP0004859_abnormal_synaptic_plasticity1.14023388
73MP0001905_abnormal_dopamine_level1.13599661
74MP0003699_abnormal_female_reproductive1.13223633
75MP0002138_abnormal_hepatobiliary_system1.12859574
76MP0002148_abnormal_hypersensitivity_rea1.10393458
77MP0005360_urolithiasis1.09407454
78MP0005248_abnormal_Harderian_gland1.08926109
79MP0000470_abnormal_stomach_morphology1.08846492
80MP0001145_abnormal_male_reproductive1.05028345
81MP0010155_abnormal_intestine_physiology1.04487911
82MP0004885_abnormal_endolymph1.04287329
83MP0004147_increased_porphyrin_level1.03788249
84MP0000579_abnormal_nail_morphology1.03490971
85MP0004133_heterotaxia0.98491637
86MP0008775_abnormal_heart_ventricle0.98219699
87MP0003635_abnormal_synaptic_transmissio0.97782970
88MP0002557_abnormal_social/conspecific_i0.97719297
89MP0001968_abnormal_touch/_nociception0.96901881
90MP0001324_abnormal_eye_pigmentation0.96572955
91MP0005646_abnormal_pituitary_gland0.96434044
92MP0001984_abnormal_olfaction0.95675868
93MP0002272_abnormal_nervous_system0.95152955
94MP0009384_cardiac_valve_regurgitation0.94611742
95* MP0001501_abnormal_sleep_pattern0.94545988
96MP0004145_abnormal_muscle_electrophysio0.94529735
97MP0002139_abnormal_hepatobiliary_system0.93129502
98MP0001293_anophthalmia0.93065413
99MP0002111_abnormal_tail_morphology0.90462894
100MP0002067_abnormal_sensory_capabilities0.90437147
101MP0001440_abnormal_grooming_behavior0.90344178
102MP0008874_decreased_physiological_sensi0.90138820
103MP0000613_abnormal_salivary_gland0.90117286
104MP0003567_abnormal_fetal_cardiomyocyte0.89592388
105MP0008058_abnormal_DNA_repair0.89322313
106MP0003936_abnormal_reproductive_system0.88760642
107MP0005253_abnormal_eye_physiology0.88016296
108MP0003638_abnormal_response/metabolism_0.87828138
109MP0003693_abnormal_embryo_hatching0.87327312
110MP0002971_abnormal_brown_adipose0.85340132
111MP0003453_abnormal_keratinocyte_physiol0.85025485
112MP0005386_behavior/neurological_phenoty0.83926269
113MP0004924_abnormal_behavior0.83926269
114MP0002837_dystrophic_cardiac_calcinosis0.82984185
115MP0002229_neurodegeneration0.80576174
116MP0001764_abnormal_homeostasis0.78965359
117MP0000604_amyloidosis0.78615316
118MP0005670_abnormal_white_adipose0.77509771
119MP0002233_abnormal_nose_morphology0.77122173
120MP0001188_hyperpigmentation0.77058781
121MP0003806_abnormal_nucleotide_metabolis0.76929348
122MP0001661_extended_life_span0.76418060
123MP0003950_abnormal_plasma_membrane0.75224744
124MP0000427_abnormal_hair_cycle0.74161562
125MP0009643_abnormal_urine_homeostasis0.73883370
126MP0000230_abnormal_systemic_arterial0.73298092
127MP0000049_abnormal_middle_ear0.73189644
128MP0002572_abnormal_emotion/affect_behav0.72668401
129MP0002735_abnormal_chemical_nociception0.72191243
130MP0003646_muscle_fatigue0.70920647
131MP0002752_abnormal_somatic_nervous0.69633841
132MP0009765_abnormal_xenobiotic_induced0.69436304
133MP0005334_abnormal_fat_pad0.68904768
134MP0000639_abnormal_adrenal_gland0.68199717
135MP0005195_abnormal_posterior_eye0.67311274
136MP0001119_abnormal_female_reproductive0.66115398
137MP0006035_abnormal_mitochondrial_morpho0.66002177
138MP0005000_abnormal_immune_tolerance0.65371084
139MP0003763_abnormal_thymus_physiology0.62908101
140MP0008004_abnormal_stomach_pH0.62457319
141MP0005671_abnormal_response_to0.62282210
142MP0004742_abnormal_vestibular_system0.62050792
143MP0009763_increased_sensitivity_to0.61664863
144MP0001502_abnormal_circadian_rhythm0.61324628
145MP0001663_abnormal_digestive_system0.61080149
146MP0000920_abnormal_myelination0.60855165
147MP0002133_abnormal_respiratory_system0.59761119
148MP0005388_respiratory_system_phenotype0.59761119
149MP0003879_abnormal_hair_cell0.59174972
150MP0001299_abnormal_eye_distance/0.59141868
151MP0009745_abnormal_behavioral_response0.58854892
152MP0002733_abnormal_thermal_nociception0.58473415
153MP0002295_abnormal_pulmonary_circulatio0.58376177
154MP0002184_abnormal_innervation0.57943206
155MP0000343_altered_response_to0.57913662
156MP0005025_abnormal_response_to0.56768083
157MP0004883_abnormal_blood_vessel0.56059750
158MP0002249_abnormal_larynx_morphology0.55278416
159MP0005377_hearing/vestibular/ear_phenot0.54474470
160MP0003878_abnormal_ear_physiology0.54474470
161MP0000383_abnormal_hair_follicle0.53951521
162MP0001486_abnormal_startle_reflex0.53344942
163MP0005197_abnormal_uvea_morphology0.51179236
164MP0002405_respiratory_system_inflammati0.50745184
165MP0005375_adipose_tissue_phenotype0.50320300
166MP0003283_abnormal_digestive_organ0.50222380
167MP0010329_abnormal_lipoprotein_level0.50136214

Predicted human phenotypes

RankGene SetZ-score
1Truncus arteriosus (HP:0001660)7.28022602
2Xerostomia (HP:0000217)6.65884618
3Abnormal ventriculo-arterial connection (HP:0011563)6.09331925
4Transposition of the great arteries (HP:0001669)6.09331925
5Abnormal connection of the cardiac segments (HP:0011545)6.09331925
6Eczematoid dermatitis (HP:0000976)5.40834283
7Chronic mucocutaneous candidiasis (HP:0002728)4.89076149
8Recurrent cutaneous fungal infections (HP:0011370)4.89076149
9Mucosal telangiectasiae (HP:0100579)4.30111283
10Sensory axonal neuropathy (HP:0003390)4.23007328
11Chronic hepatic failure (HP:0100626)4.08547911
12Hypertensive crisis (HP:0100735)4.08319263
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.89419692
14Colon cancer (HP:0003003)3.74228270
15Recurrent gram-negative bacterial infections (HP:0005420)3.71083570
16Abnormality of alanine metabolism (HP:0010916)3.67183259
17Hyperalaninemia (HP:0003348)3.67183259
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.67183259
19Nephronophthisis (HP:0000090)3.58044484
20Spontaneous hematomas (HP:0007420)3.50933946
21Hematochezia (HP:0002573)3.47370032
22Tubular atrophy (HP:0000092)3.44293530
23Severe visual impairment (HP:0001141)3.40296835
24Recurrent skin infections (HP:0001581)3.31457705
25Abnormal biliary tract physiology (HP:0012439)3.24462025
26Bile duct proliferation (HP:0001408)3.24462025
27Recurrent fungal infections (HP:0002841)3.24219543
28True hermaphroditism (HP:0010459)3.22379527
29Rectal prolapse (HP:0002035)3.18937858
30Pancreatic cysts (HP:0001737)3.18363332
31Aplasia/Hypoplasia of the spleen (HP:0010451)3.14509755
32Abnormality of calcium-phosphate metabolism (HP:0100530)3.13717112
33Retinal atrophy (HP:0001105)3.10496293
34Pancreatic fibrosis (HP:0100732)3.07490844
35Vertebral arch anomaly (HP:0008438)3.03115315
36Abnormality of midbrain morphology (HP:0002418)3.00428618
37Molar tooth sign on MRI (HP:0002419)3.00428618
38Impulsivity (HP:0100710)2.94795200
39Cerebral hypomyelination (HP:0006808)2.91923220
40Asplenia (HP:0001746)2.90087288
41Conjunctival telangiectasia (HP:0000524)2.88658569
42Abnormality of the renal cortex (HP:0011035)2.82511611
43Abnormal respiratory motile cilium physiology (HP:0012261)2.80439190
44Abnormal ciliary motility (HP:0012262)2.77840871
45Reduced antithrombin III activity (HP:0001976)2.75021433
46Recurrent bacterial skin infections (HP:0005406)2.74341755
47Abnormality of the renal medulla (HP:0100957)2.71211273
48Lip pit (HP:0100267)2.71175846
49Pigmentary retinal degeneration (HP:0001146)2.68725005
50Partial duplication of thumb phalanx (HP:0009944)2.66945025
51Brushfield spots (HP:0001088)2.66861986
52Abnormality of the lower motor neuron (HP:0002366)2.66555561
53Oligodactyly (hands) (HP:0001180)2.65918469
54Absent/shortened dynein arms (HP:0200106)2.63115891
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.63115891
56Abdominal situs inversus (HP:0003363)2.62787484
57Abnormality of abdominal situs (HP:0011620)2.62787484
58Stage 5 chronic kidney disease (HP:0003774)2.59542537
59Abnormality of salivation (HP:0100755)2.59023778
60Camptodactyly of toe (HP:0001836)2.58285528
61Partial duplication of the phalanx of hand (HP:0009999)2.57934086
62Hyperglycinemia (HP:0002154)2.57927990
63Acrocyanosis (HP:0001063)2.57329552
64Polydipsia (HP:0001959)2.56351271
65Abnormal drinking behavior (HP:0030082)2.56351271
66Gait imbalance (HP:0002141)2.54016799
67Sclerocornea (HP:0000647)2.53767174
68Medial flaring of the eyebrow (HP:0010747)2.51618797
69Hyperglycinuria (HP:0003108)2.50156480
70Hypercortisolism (HP:0001578)2.48025631
71Chondrocalcinosis (HP:0000934)2.47308239
72Congenital primary aphakia (HP:0007707)2.46311111
73Abnormality of glycine metabolism (HP:0010895)2.45697810
74Abnormality of serine family amino acid metabolism (HP:0010894)2.45697810
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.45512957
76Anencephaly (HP:0002323)2.45500652
77Abnormal mitochondria in muscle tissue (HP:0008316)2.44224849
78Abnormality of Sharpey fibers (HP:0100685)2.43337102
79Keratoconjunctivitis (HP:0001096)2.41058859
80Progressive muscle weakness (HP:0003323)2.37642576
81Right ventricular cardiomyopathy (HP:0011663)2.37391402
82Congenital hepatic fibrosis (HP:0002612)2.37375471
83Dyskinesia (HP:0100660)2.37209492
84Septo-optic dysplasia (HP:0100842)2.31124766
85Agammaglobulinemia (HP:0004432)2.30632120
86Nephrogenic diabetes insipidus (HP:0009806)2.30422976
87Abnormality of serum amino acid levels (HP:0003112)2.29261765
88Occipital encephalocele (HP:0002085)2.28097981
89Postaxial foot polydactyly (HP:0001830)2.24948139
90Panhypogammaglobulinemia (HP:0003139)2.24137972
91Type I diabetes mellitus (HP:0100651)2.23947841
92Broad ribs (HP:0000885)2.23272397
93Acute necrotizing encephalopathy (HP:0006965)2.22249340
94Interstitial pulmonary disease (HP:0006530)2.21914453
95Congenital stationary night blindness (HP:0007642)2.21578082
96Insidious onset (HP:0003587)2.21484082
97Termporal pattern (HP:0011008)2.21484082
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.21294011
99Retinal dysplasia (HP:0007973)2.21220126
100Tongue fasciculations (HP:0001308)2.20430596
101Pulmonary fibrosis (HP:0002206)2.20167891
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.19225666
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19225666
104Cystic liver disease (HP:0006706)2.19108466
105Amyotrophic lateral sclerosis (HP:0007354)2.16678233
106Oligodactyly (HP:0012165)2.16205886
107Tubulointerstitial fibrosis (HP:0005576)2.13885811
108Preaxial hand polydactyly (HP:0001177)2.13788144
109Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11551427
110Paraparesis (HP:0002385)2.11221836
111Lipid accumulation in hepatocytes (HP:0006561)2.09150132
112Spastic paraparesis (HP:0002313)2.09045018
113Abnormal pupillary function (HP:0007686)2.07199120
114Palpebral edema (HP:0100540)2.01979102
115Acute encephalopathy (HP:0006846)2.00610999
116Cerebral edema (HP:0002181)2.00525712
117Poor coordination (HP:0002370)2.00424225
118Osteomalacia (HP:0002749)2.00301665
119Congenital malformation of the right heart (HP:0011723)13.2671386
120Double outlet right ventricle (HP:0001719)13.2671386
121Microcytic anemia (HP:0001935)1.99698485
122Muscle fibrillation (HP:0010546)1.99104823
123Pulmonary infiltrates (HP:0002113)1.97242317
124Cholelithiasis (HP:0001081)1.97203221
125Intrahepatic cholestasis (HP:0001406)1.93986750
126Abnormality of the labia minora (HP:0012880)1.92133213
127Genital tract atresia (HP:0001827)1.91168610
128Azoospermia (HP:0000027)1.90874723
129Abnormality of the corticospinal tract (HP:0002492)1.90747938
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90515594
131Absent septum pellucidum (HP:0001331)1.89511573
132Chronic obstructive pulmonary disease (HP:0006510)1.88830420
133Obstructive lung disease (HP:0006536)1.88830420
134Tetraparesis (HP:0002273)1.87706732
135Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87341758
136Rhinitis (HP:0012384)1.86929157
137Male pseudohermaphroditism (HP:0000037)1.86094876
138Esophageal varix (HP:0002040)1.85972570
139Vaginal atresia (HP:0000148)1.84750304
140Focal motor seizures (HP:0011153)1.83702771
141Upper limb muscle weakness (HP:0003484)1.83237288
142Arterial tortuosity (HP:0005116)1.83197837
143Recurrent abscess formation (HP:0002722)1.83010099
144Flexion contracture of toe (HP:0005830)1.82881519
145Joint contractures involving the joints of the feet (HP:0100492)1.82881519
146Birth length less than 3rd percentile (HP:0003561)1.82511191
147Optic nerve hypoplasia (HP:0000609)1.82492088
148Hepatitis (HP:0012115)1.82349446
149Polyuria (HP:0000103)1.81405927
150Partial agenesis of the corpus callosum (HP:0001338)1.80970225
151Retinitis pigmentosa (HP:0000510)1.79838184
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79597481
153Gingivitis (HP:0000230)1.78866026
154Steatorrhea (HP:0002570)1.78619193
155Tubulointerstitial abnormality (HP:0001969)1.78291756
156Congenital sensorineural hearing impairment (HP:0008527)1.78009499
157Gonadotropin excess (HP:0000837)1.77438466
158Median cleft lip (HP:0000161)1.76922990
159Abnormality of the phalanges of the hallux (HP:0010057)1.76392715
160Abnormal gallbladder morphology (HP:0012437)1.76322800
161Cortical visual impairment (HP:0100704)1.75300275
162Abnormality of macrophages (HP:0004311)1.74085004
163Resting tremor (HP:0002322)1.73885180
164Furrowed tongue (HP:0000221)1.73783788
165Colitis (HP:0002583)1.73634701
166Teleangiectasia of the skin (HP:0100585)1.73526542
167Abnormal urine phosphate concentration (HP:0012599)1.73421473
168Mitral valve prolapse (HP:0001634)1.72740777
169Aplasia/Hypoplasia of the ulna (HP:0006495)1.72374656
170Type II lissencephaly (HP:0007260)1.72298073
171Congenital, generalized hypertrichosis (HP:0004540)1.71469704
172Abnormal urine output (HP:0012590)1.70701931
173Generalized aminoaciduria (HP:0002909)1.69083994
174Myokymia (HP:0002411)1.68739081
175Morphological abnormality of the pyramidal tract (HP:0002062)1.68585959
176Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67396609
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67289126
178Infertility (HP:0000789)1.66667587
179Hypoparathyroidism (HP:0000829)1.66169929
180Cellulitis (HP:0100658)1.63467541
181Agitation (HP:0000713)1.61261068
182Hypokalemia (HP:0002900)1.60651811
183Poor eye contact (HP:0000817)1.60048582
184Vascular tortuosity (HP:0004948)1.59913411
185Fat malabsorption (HP:0002630)1.58942061
186Female pseudohermaphroditism (HP:0010458)1.57750623
187Prolonged partial thromboplastin time (HP:0003645)1.56808308
188Absence seizures (HP:0002121)1.55123611
189Abnormality of the heme biosynthetic pathway (HP:0010472)1.53368006
190Inflammation of the large intestine (HP:0002037)1.53250249
191Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.52477170
192Progressive macrocephaly (HP:0004481)1.52205596
193Oral leukoplakia (HP:0002745)1.52168379
194Spondylolisthesis (HP:0003302)1.50941678
195Overlapping toe (HP:0001845)1.49505676
196Abnormality of the gastric mucosa (HP:0004295)1.49269097
197Mediastinal lymphadenopathy (HP:0100721)1.48744732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK5.26258881
2CAMK1D4.67888331
3TNIK4.67215900
4MAP4K24.13970913
5PRKD34.10812486
6EPHA33.95806389
7PRKCI3.72504096
8CAMK1G3.51786509
9NTRK13.25244021
10MAP3K143.17556439
11FLT32.94288730
12MAP3K92.93578649
13INSRR2.79724460
14PIM22.71905594
15CCNB12.68980839
16EPHB12.40142079
17ZAK2.36701405
18MET2.26758174
19MAP3K132.14194487
20MAP2K22.08038015
21MAP3K42.06215767
22PLK41.94148646
23IRAK41.91027840
24NTRK21.88673234
25TEC1.88383795
26PRKD21.87664739
27LRRK21.86274608
28MAPK151.83541229
29JAK31.81137032
30MELK1.74123404
31TYK21.72914833
32RAF11.68668150
33PNCK1.63175822
34PIK3CG1.62416327
35SIK21.62259801
36TAOK11.62080289
37PTK61.55885436
38ERBB31.54817857
39ITK1.53813037
40FGFR41.53524039
41BRSK21.52295031
42DYRK21.44861521
43PDGFRA1.33759282
44PINK11.31383514
45PBK1.27332713
46SCYL21.26322729
47CDC71.25673515
48BTK1.24270100
49CDK191.23037546
50BMPR1B1.18449976
51TESK11.13777484
52NEK61.13754016
53MAPKAPK31.10655620
54MAP4K11.10418776
55TESK21.09269625
56STK111.09026399
57KDR1.07558704
58JAK21.06466796
59STK38L1.04667771
60VRK11.01723648
61TIE11.00324669
62TNK20.93969151
63MARK10.93198492
64MAP3K110.92882851
65MAP3K120.92667410
66ACVR1B0.91095392
67STK390.90855146
68HCK0.90210248
69CDK120.87935209
70SRPK10.87777136
71ALK0.87040576
72WNK40.80651930
73BMPR20.79889507
74AURKA0.79710242
75SYK0.78527728
76MATK0.77990089
77FER0.77833359
78PTK2B0.77799673
79PRKCQ0.76789087
80TYRO30.75848061
81PRKG20.75526349
82BCKDK0.74300378
83MAP3K10.72700896
84ILK0.70570641
85MAP3K60.69666406
86DYRK1B0.69309959
87TRIM280.67441254
88EIF2AK30.65925544
89TGFBR10.65610435
90CDK30.65369435
91ARAF0.65261132
92MAP3K70.64887746
93MST1R0.63877170
94EPHA40.63695088
95TTK0.63626768
96CASK0.63119573
97CHEK20.62805341
98NTRK30.62108397
99TSSK60.59851767
100MUSK0.58010032
101UHMK10.57381361
102DAPK10.56956508
103CAMK2G0.56743710
104MAPKAPK50.56443974
105PAK60.56336363
106BRAF0.56079670
107PAK30.55747617
108PLK30.55080195
109MAPK130.54626805
110PAK20.54594878
111PRKAA10.54592288
112AKT20.53318926
113BMX0.51842691
114TLK10.50441020
115MARK20.50381552
116PRKCD0.48812897
117CAMK40.47522269
118RPS6KA40.47316560
119KIT0.47003389
120JAK10.46686621
121MKNK10.46107627
122OXSR10.46102257
123FES0.45913629
124IGF1R0.45158820
125CAMK2A0.45075055
126GRK10.44583846
127CAMKK20.43151658
128PRKACA0.42602573
129NEK20.42488034
130ATM0.41273031
131PRKAA20.40633451
132CDK90.40529680
133EEF2K0.39840982
134PRKG10.39501956
135DDR20.39372370
136TTN0.37413410
137FRK0.36555617
138PRKCG0.35983527
139CAMK2B0.35351768
140PKN10.35089789
141CDK70.34453236
142PLK20.34325241
143RPS6KA50.33814818
144SRC0.33566867
145PLK10.33296716
146BRSK10.33020523
147AURKB0.32731060
148PRKCE0.32326826
149BCR0.32232079
150GSK3A0.31996525
151CDK50.31674620
152PHKG20.31491421
153PHKG10.31491421
154ZAP700.30490293
155PRKCZ0.28954220
156DYRK30.28252558
157MAPK90.27542281
158MYLK0.27338037
159CAMK10.26327949
160FYN0.25993761
161NME10.25882980
162TRPM70.25027350
163PRKCH0.22136053
164WNK30.22063223
165HIPK20.21102284
166PTK20.21073944
167PRKCA0.20511468
168ROCK20.19989593
169PRKCB0.19958874

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002206.23831423
2Asthma_Homo sapiens_hsa053104.39451123
3Linoleic acid metabolism_Homo sapiens_hsa005914.13272580
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.95744991
5Fatty acid biosynthesis_Homo sapiens_hsa000613.81675184
6Dorso-ventral axis formation_Homo sapiens_hsa043203.45893279
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81055888
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.71934395
9Arginine and proline metabolism_Homo sapiens_hsa003302.59009373
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.47505684
11Sulfur relay system_Homo sapiens_hsa041222.36278261
12Nicotine addiction_Homo sapiens_hsa050332.20352988
13ABC transporters_Homo sapiens_hsa020102.10211274
14Basal transcription factors_Homo sapiens_hsa030222.08074124
15Oxidative phosphorylation_Homo sapiens_hsa001902.05479519
16Caffeine metabolism_Homo sapiens_hsa002322.03568990
17Steroid biosynthesis_Homo sapiens_hsa001002.02025371
18Ether lipid metabolism_Homo sapiens_hsa005651.98603435
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95035822
20Pyruvate metabolism_Homo sapiens_hsa006201.93678764
21Chemical carcinogenesis_Homo sapiens_hsa052041.79886964
22Primary immunodeficiency_Homo sapiens_hsa053401.78211718
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.76654723
24Salivary secretion_Homo sapiens_hsa049701.58625135
25Arachidonic acid metabolism_Homo sapiens_hsa005901.53781786
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36005177
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34382766
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33237523
29RNA polymerase_Homo sapiens_hsa030201.30089054
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.29719300
31Alzheimers disease_Homo sapiens_hsa050101.29426729
32Leishmaniasis_Homo sapiens_hsa051401.28845021
33Parkinsons disease_Homo sapiens_hsa050121.28636477
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.26807335
35Selenocompound metabolism_Homo sapiens_hsa004501.25109491
36Vitamin B6 metabolism_Homo sapiens_hsa007501.24815199
37Glutamatergic synapse_Homo sapiens_hsa047241.23587358
38Base excision repair_Homo sapiens_hsa034101.23261542
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23021628
40Amoebiasis_Homo sapiens_hsa051461.19042859
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.16709733
42Melanoma_Homo sapiens_hsa052181.11803054
43Nitrogen metabolism_Homo sapiens_hsa009101.10117068
44African trypanosomiasis_Homo sapiens_hsa051431.10086167
45Retinol metabolism_Homo sapiens_hsa008301.09575411
46Fat digestion and absorption_Homo sapiens_hsa049751.08462245
47Bile secretion_Homo sapiens_hsa049761.07122452
48Homologous recombination_Homo sapiens_hsa034401.06755760
49Biosynthesis of amino acids_Homo sapiens_hsa012301.05148229
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02574043
51Chronic myeloid leukemia_Homo sapiens_hsa052201.02562617
52Pancreatic cancer_Homo sapiens_hsa052121.00977577
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00547837
54Serotonergic synapse_Homo sapiens_hsa047261.00196336
55Chemokine signaling pathway_Homo sapiens_hsa040620.99817133
56Phototransduction_Homo sapiens_hsa047440.99185459
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99073579
58Calcium signaling pathway_Homo sapiens_hsa040200.97518542
59Fatty acid degradation_Homo sapiens_hsa000710.93235211
60One carbon pool by folate_Homo sapiens_hsa006700.91751132
61Histidine metabolism_Homo sapiens_hsa003400.91194399
62PPAR signaling pathway_Homo sapiens_hsa033200.90913662
63Ovarian steroidogenesis_Homo sapiens_hsa049130.88480255
64Cardiac muscle contraction_Homo sapiens_hsa042600.88470410
65Fanconi anemia pathway_Homo sapiens_hsa034600.88055128
66Taste transduction_Homo sapiens_hsa047420.86968749
67Propanoate metabolism_Homo sapiens_hsa006400.83752135
68beta-Alanine metabolism_Homo sapiens_hsa004100.82293628
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81705653
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80498213
71RNA degradation_Homo sapiens_hsa030180.79691816
72Gastric acid secretion_Homo sapiens_hsa049710.79328878
73Circadian entrainment_Homo sapiens_hsa047130.79153256
74Amphetamine addiction_Homo sapiens_hsa050310.78826221
75Peroxisome_Homo sapiens_hsa041460.78644179
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.78297615
77Complement and coagulation cascades_Homo sapiens_hsa046100.75399696
78Olfactory transduction_Homo sapiens_hsa047400.74872409
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74598382
80Inositol phosphate metabolism_Homo sapiens_hsa005620.74408044
81Osteoclast differentiation_Homo sapiens_hsa043800.74254993
82Tryptophan metabolism_Homo sapiens_hsa003800.73701327
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71092164
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.69187034
85Long-term depression_Homo sapiens_hsa047300.69041680
86GABAergic synapse_Homo sapiens_hsa047270.68940183
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68515499
88MAPK signaling pathway_Homo sapiens_hsa040100.68438022
89Starch and sucrose metabolism_Homo sapiens_hsa005000.68254466
90Dilated cardiomyopathy_Homo sapiens_hsa054140.67499908
91Oocyte meiosis_Homo sapiens_hsa041140.66836284
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66556492
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.66316371
94Malaria_Homo sapiens_hsa051440.65791352
95Antigen processing and presentation_Homo sapiens_hsa046120.64065666
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64035006
97Synaptic vesicle cycle_Homo sapiens_hsa047210.62793964
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61838108
99Metabolic pathways_Homo sapiens_hsa011000.60973940
100Cocaine addiction_Homo sapiens_hsa050300.60032563
101Pertussis_Homo sapiens_hsa051330.59890754
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59423695
103Lysine degradation_Homo sapiens_hsa003100.57611032
104Phenylalanine metabolism_Homo sapiens_hsa003600.57151873
105Vitamin digestion and absorption_Homo sapiens_hsa049770.57080537
106Purine metabolism_Homo sapiens_hsa002300.56765284
107Cell cycle_Homo sapiens_hsa041100.55308175
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54239821
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53835874
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53818410
111Sulfur metabolism_Homo sapiens_hsa009200.53618953
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53587405
113Morphine addiction_Homo sapiens_hsa050320.53308856
114Fatty acid metabolism_Homo sapiens_hsa012120.53110482
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52870350
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52430550
117Prolactin signaling pathway_Homo sapiens_hsa049170.51310821
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50807685
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.50219228
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49701204
121Rheumatoid arthritis_Homo sapiens_hsa053230.48638542
122Butanoate metabolism_Homo sapiens_hsa006500.48052140
123Pyrimidine metabolism_Homo sapiens_hsa002400.47839648
124Huntingtons disease_Homo sapiens_hsa050160.47023108
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46750332
126Mismatch repair_Homo sapiens_hsa034300.46455941
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46394617
128Renin secretion_Homo sapiens_hsa049240.46331085
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45515796
130Rap1 signaling pathway_Homo sapiens_hsa040150.45278284
131* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45210150
132Staphylococcus aureus infection_Homo sapiens_hsa051500.44894324
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44092008
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43735664
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.43508872
136Insulin secretion_Homo sapiens_hsa049110.42721640
137Non-homologous end-joining_Homo sapiens_hsa034500.42421720
138Cholinergic synapse_Homo sapiens_hsa047250.42220259
139Tyrosine metabolism_Homo sapiens_hsa003500.41233733
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40577553
141Circadian rhythm_Homo sapiens_hsa047100.37855561
142Hedgehog signaling pathway_Homo sapiens_hsa043400.37650638
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36153197
144Protein digestion and absorption_Homo sapiens_hsa049740.35807439
145RNA transport_Homo sapiens_hsa030130.35706181
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.35659081
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34637171
148ErbB signaling pathway_Homo sapiens_hsa040120.34449169
149Fatty acid elongation_Homo sapiens_hsa000620.34390643
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34030763
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33933123
152Ras signaling pathway_Homo sapiens_hsa040140.33753456
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.32789356
154Folate biosynthesis_Homo sapiens_hsa007900.31208054
155Gap junction_Homo sapiens_hsa045400.30172091

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