GID4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.37726373
2regulation of meiosis I (GO:0060631)5.19571101
3mitotic metaphase plate congression (GO:0007080)4.72098203
4monoubiquitinated protein deubiquitination (GO:0035520)4.71260062
5regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.58921571
6nuclear pore organization (GO:0006999)4.50690491
7IMP biosynthetic process (GO:0006188)4.49353682
8DNA methylation involved in gamete generation (GO:0043046)4.39760914
9IMP metabolic process (GO:0046040)4.24839536
10cranial nerve morphogenesis (GO:0021602)4.24014273
11purine nucleobase biosynthetic process (GO:0009113)4.19109682
12neural tube formation (GO:0001841)4.18079371
13tricarboxylic acid cycle (GO:0006099)4.13940132
14ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043164.06127590
15nuclear pore complex assembly (GO:0051292)4.00237444
16biotin metabolic process (GO:0006768)3.99760242
17response to pheromone (GO:0019236)3.97813571
18cornea development in camera-type eye (GO:0061303)3.96328159
19regulation of G0 to G1 transition (GO:0070316)3.95825549
20regulation of acyl-CoA biosynthetic process (GO:0050812)3.86451605
21establishment of protein localization to Golgi (GO:0072600)3.82075310
22actin-myosin filament sliding (GO:0033275)3.82060768
23muscle filament sliding (GO:0030049)3.82060768
24glucocorticoid receptor signaling pathway (GO:0042921)3.81707951
25ubiquinone biosynthetic process (GO:0006744)3.81202271
26metaphase plate congression (GO:0051310)3.79865766
27protein localization to microtubule cytoskeleton (GO:0072698)3.77529719
28interkinetic nuclear migration (GO:0022027)3.76039311
29protein localization to cytoskeleton (GO:0044380)3.75018038
30valine metabolic process (GO:0006573)3.73476631
31attachment of spindle microtubules to kinetochore (GO:0008608)3.72974362
32male meiosis I (GO:0007141)3.70066429
33protein targeting to Golgi (GO:0000042)3.63738413
34NADH metabolic process (GO:0006734)3.61510618
35regulation of glycogen (starch) synthase activity (GO:2000465)3.55254200
36replication fork processing (GO:0031297)3.54299317
37carnitine shuttle (GO:0006853)3.53826310
38nucleobase biosynthetic process (GO:0046112)3.53631462
39protein localization to Golgi apparatus (GO:0034067)3.49039844
40regulation of translational termination (GO:0006449)3.47866272
41protein localization to kinetochore (GO:0034501)3.47791414
42retrograde transport, vesicle recycling within Golgi (GO:0000301)3.47659495
43behavioral response to nicotine (GO:0035095)3.46990288
44misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.46431793
45regulation of coenzyme metabolic process (GO:0051196)3.45161834
46regulation of cofactor metabolic process (GO:0051193)3.45161834
47negative regulation of cAMP-mediated signaling (GO:0043951)3.40874424
48somite development (GO:0061053)3.40810143
49muscle cell fate commitment (GO:0042693)3.39525515
50corticosteroid receptor signaling pathway (GO:0031958)3.39327687
51sarcoplasmic reticulum calcium ion transport (GO:0070296)3.37720979
52regulation of acrosome reaction (GO:0060046)3.36067167
53cellular protein complex localization (GO:0034629)3.32829820
54protein K11-linked deubiquitination (GO:0035871)3.32503379
55establishment of chromosome localization (GO:0051303)3.32302222
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.31606004
57negative regulation of dendrite morphogenesis (GO:0050774)3.27237367
58negative regulation of transcription regulatory region DNA binding (GO:2000678)3.23623824
59ubiquinone metabolic process (GO:0006743)3.23416180
60branched-chain amino acid catabolic process (GO:0009083)3.21615326
61negative regulation of muscle hypertrophy (GO:0014741)3.19508211
62fatty acid transmembrane transport (GO:1902001)3.18331142
63positive regulation of meiosis (GO:0045836)3.17745969
64DNA replication checkpoint (GO:0000076)3.14556761
65regulation of cell maturation (GO:1903429)3.13435682
66negative regulation of DNA-dependent DNA replication (GO:2000104)3.12858213
67pore complex assembly (GO:0046931)3.12146595
68negative regulation of cardiac muscle hypertrophy (GO:0010614)3.11365591
69mitotic sister chromatid cohesion (GO:0007064)3.11088012
70parturition (GO:0007567)3.10218713
71inner mitochondrial membrane organization (GO:0007007)3.09449603
72protein localization to cilium (GO:0061512)3.09099316
73protein complex localization (GO:0031503)3.08929682
74cellular response to ATP (GO:0071318)3.08389495
75muscle organ morphogenesis (GO:0048644)3.08360341
76negative regulation of fatty acid biosynthetic process (GO:0045717)3.04591891
77actin-mediated cell contraction (GO:0070252)3.03207488
78regulation of skeletal muscle contraction (GO:0014819)3.01415610
79regulation of gene expression by genetic imprinting (GO:0006349)3.01240619
80protein deneddylation (GO:0000338)3.00846067
81oxaloacetate metabolic process (GO:0006107)3.00243436
82positive regulation of meiotic cell cycle (GO:0051446)2.99470749
83polyketide metabolic process (GO:0030638)2.96988747
84doxorubicin metabolic process (GO:0044598)2.96988747
85daunorubicin metabolic process (GO:0044597)2.96988747
86multicellular organism reproduction (GO:0032504)2.96458800
87carnitine transmembrane transport (GO:1902603)2.95277228
88ribosome biogenesis (GO:0042254)2.94711937
89acrosome reaction (GO:0007340)2.94226374
90CENP-A containing nucleosome assembly (GO:0034080)2.90755715
91branched-chain amino acid metabolic process (GO:0009081)2.90482655
92cellular ketone body metabolic process (GO:0046950)2.89434301
93protein polyglutamylation (GO:0018095)2.89110013
94outer ear morphogenesis (GO:0042473)2.86861896
95metanephric mesenchyme development (GO:0072075)2.85357819
96oxidative demethylation (GO:0070989)2.85261577
97embryonic epithelial tube formation (GO:0001838)2.85138983
98mitotic nuclear envelope disassembly (GO:0007077)2.84738406
99mitotic sister chromatid segregation (GO:0000070)2.84021769
100protein localization to chromosome, centromeric region (GO:0071459)2.82710381
101lymph vessel development (GO:0001945)2.81673679
102inositol metabolic process (GO:0006020)2.80978604
103regulation of DNA-templated transcription, initiation (GO:2000142)2.80099396
104synaptonemal complex organization (GO:0070193)2.78422475
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.78152440
106myofibril assembly (GO:0030239)2.78014058
107meiosis I (GO:0007127)2.77682852
108chromatin remodeling at centromere (GO:0031055)2.77147798
109lysine catabolic process (GO:0006554)2.76905314
110lysine metabolic process (GO:0006553)2.76905314
111male meiosis (GO:0007140)2.76209727
112inositol phosphate catabolic process (GO:0071545)2.75506435
113oxidative phosphorylation (GO:0006119)2.75360058
114maturation of 5.8S rRNA (GO:0000460)2.75323264
115positive regulation of T cell cytokine production (GO:0002726)2.74986179
116regulation of exit from mitosis (GO:0007096)2.74097721
117regulation of sequestering of triglyceride (GO:0010889)2.71947132
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71859032
119synaptonemal complex assembly (GO:0007130)2.71084287
120spinal cord motor neuron differentiation (GO:0021522)2.70933678
121quinone biosynthetic process (GO:1901663)2.70712776
122detection of light stimulus involved in visual perception (GO:0050908)2.70055924
123detection of light stimulus involved in sensory perception (GO:0050962)2.70055924
124intracellular lipid transport (GO:0032365)2.69497920
1252-oxoglutarate metabolic process (GO:0006103)2.69072293
126regulation of sulfur metabolic process (GO:0042762)2.68123800
127regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.67808667
128response to inactivity (GO:0014854)2.67161417
129spindle checkpoint (GO:0031577)2.67132084
130reciprocal meiotic recombination (GO:0007131)2.65958068
131reciprocal DNA recombination (GO:0035825)2.65958068
132nuclear envelope disassembly (GO:0051081)2.65563447
133membrane disassembly (GO:0030397)2.65563447
134amino-acid betaine transport (GO:0015838)2.65134218
135carnitine transport (GO:0015879)2.65134218
136negative regulation of cell aging (GO:0090344)2.64291104
137histone exchange (GO:0043486)2.63837954
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.63550781
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63550781
140regulation of spindle organization (GO:0090224)2.63371636
141calcium ion import (GO:0070509)2.62392745
142epithelial tube formation (GO:0072175)2.62284642
143DNA deamination (GO:0045006)2.61540676
144DNA integrity checkpoint (GO:0031570)2.61277619
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60630243
146folic acid-containing compound biosynthetic process (GO:0009396)2.60380074
147regulation of mitotic spindle checkpoint (GO:1903504)2.60312593
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60312593
149transcription from mitochondrial promoter (GO:0006390)2.60128588
150succinate metabolic process (GO:0006105)2.59950375
151microtubule severing (GO:0051013)2.59301199
152DNA damage checkpoint (GO:0000077)2.59289993
153inositol phosphate dephosphorylation (GO:0046855)2.59268397
154phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59268397
155G2 DNA damage checkpoint (GO:0031572)2.58000361
156regulation of DNA endoreduplication (GO:0032875)2.57660267
157kidney mesenchyme development (GO:0072074)2.56097224
158meiotic chromosome segregation (GO:0045132)2.55527369
159sister chromatid cohesion (GO:0007062)2.54986450
160negative regulation of necroptotic process (GO:0060546)2.54173535
161negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.53586884
162ketone body metabolic process (GO:1902224)2.53281529
163cardiovascular system development (GO:0072358)2.53231461
164regulation of action potential (GO:0098900)2.52692019
165lens fiber cell differentiation (GO:0070306)2.51977938
166positive regulation of DNA-dependent DNA replication (GO:2000105)2.50266558
167N-terminal protein amino acid acetylation (GO:0006474)2.50224020
168positive regulation of mitotic sister chromatid separation (GO:1901970)2.50079840
169positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50079840
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50079840
171regulation of female gonad development (GO:2000194)2.49693961
172nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.48901423
173cellular response to gamma radiation (GO:0071480)2.48667442
174positive regulation of mitochondrial fission (GO:0090141)2.48546034
175response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.47813270
176heart process (GO:0003015)2.47000528
177heart contraction (GO:0060047)2.47000528
178serine family amino acid catabolic process (GO:0009071)2.46592040
179negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46247636
180protein K6-linked ubiquitination (GO:0085020)2.46059293
181histone H2A acetylation (GO:0043968)2.45798593
182sister chromatid segregation (GO:0000819)2.45638770
183DNA double-strand break processing (GO:0000729)2.45600807
184chromosome organization involved in meiosis (GO:0070192)2.45074630
185protein localization to synapse (GO:0035418)2.44996676
186regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44577372
187regulation of DNA methylation (GO:0044030)2.44184386
188thyroid gland development (GO:0030878)2.43405546
189rRNA catabolic process (GO:0016075)2.43185157
190sperm motility (GO:0030317)2.42047428
191neuromuscular synaptic transmission (GO:0007274)2.40630010
192aspartate family amino acid catabolic process (GO:0009068)2.40125025
193cardiac myofibril assembly (GO:0055003)2.39003761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.29789857
2EZH2_22144423_ChIP-Seq_EOC_Human3.91015527
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.70279320
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.69486130
5ZNF274_21170338_ChIP-Seq_K562_Hela3.62278115
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.61752483
7PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse3.47065056
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13126083
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09326433
10AR_21909140_ChIP-Seq_LNCAP_Human2.97345208
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97103513
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94455101
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.86765787
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.75360104
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74278396
16IGF1R_20145208_ChIP-Seq_DFB_Human2.58517132
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54546445
18GBX2_23144817_ChIP-Seq_PC3_Human2.54424379
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.52249838
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45991869
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.41769161
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.38545086
23VDR_22108803_ChIP-Seq_LS180_Human2.33600760
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25272599
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13200460
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.11295793
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05100694
28FUS_26573619_Chip-Seq_HEK293_Human2.03392690
29GATA1_22025678_ChIP-Seq_K562_Human1.98736304
30CIITA_25753668_ChIP-Seq_RAJI_Human1.96257191
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94659734
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93897684
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.93822214
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93200781
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88823765
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87070155
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85409634
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82746124
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77543868
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76671740
41P300_19829295_ChIP-Seq_ESCs_Human1.76439375
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73086136
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.72789890
44GATA4_21415370_ChIP-Seq_HL-1_Mouse1.72478355
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72269490
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71343598
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71212041
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70598054
49KDM5A_27292631_Chip-Seq_BREAST_Human1.70211113
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68289394
51RNF2_27304074_Chip-Seq_NSC_Mouse1.67590724
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64292986
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63746900
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62544285
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62408990
56GABP_19822575_ChIP-Seq_HepG2_Human1.59838126
57SMAD4_21799915_ChIP-Seq_A2780_Human1.59175708
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58226647
59CBP_20019798_ChIP-Seq_JUKART_Human1.56454314
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56454314
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55556669
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55234602
63STAT3_23295773_ChIP-Seq_U87_Human1.53234071
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53157817
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.53136413
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.52667424
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51699775
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51268227
69TAF15_26573619_Chip-Seq_HEK293_Human1.51044547
70EWS_26573619_Chip-Seq_HEK293_Human1.50945826
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50646435
72TCF4_23295773_ChIP-Seq_U87_Human1.49144012
73AR_21572438_ChIP-Seq_LNCaP_Human1.48496765
74ER_23166858_ChIP-Seq_MCF-7_Human1.47141648
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46581528
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46283118
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.46246033
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45769638
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44070357
80FOXP3_21729870_ChIP-Seq_TREG_Human1.44024264
81ZNF263_19887448_ChIP-Seq_K562_Human1.42219477
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.42048940
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41474827
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40546985
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39590067
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39414589
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39408059
88AR_25329375_ChIP-Seq_VCAP_Human1.38919956
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38746897
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38603060
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38603060
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38120606
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.37053435
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.36673642
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36464276
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36259266
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33072112
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32433468
99VDR_23849224_ChIP-Seq_CD4+_Human1.31560517
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31553640
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.29415811
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29167854
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27932479
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26836212
105SOX2_19829295_ChIP-Seq_ESCs_Human1.26616577
106NANOG_19829295_ChIP-Seq_ESCs_Human1.26616577
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25164852
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24886904
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24533025
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.24121259
111TP53_22573176_ChIP-Seq_HFKS_Human1.23751863
112MYC_22102868_ChIP-Seq_BL_Human1.23628412
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.21764838
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20424430
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.19684001
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18197104
117E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17749669
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17708200
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.17426105
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17426105
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.16439482
122GABP_17652178_ChIP-ChIP_JURKAT_Human1.16190973
123TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15985793
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15696038
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.15474719
126ESR1_20079471_ChIP-ChIP_T-47D_Human1.15350733
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14303367
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13461199
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12962913
130XRN2_22483619_ChIP-Seq_HELA_Human1.12500489
131PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11231223
132NCOR_22424771_ChIP-Seq_293T_Human1.10734879
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10612213
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10215150
135ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09832083
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09789674
137REST_21632747_ChIP-Seq_MESCs_Mouse1.09766931
138TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09593285
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09367128
140GATA3_21878914_ChIP-Seq_MCF-7_Human1.09023683
141YY1_21170310_ChIP-Seq_MESCs_Mouse1.08624351
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07996694
143ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07883879
144SMAD3_21741376_ChIP-Seq_EPCs_Human1.05783765
145TP53_20018659_ChIP-ChIP_R1E_Mouse1.04991966
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04536159
147NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04400184
148MYC_18940864_ChIP-ChIP_HL60_Human1.04134202
149NANOG_20526341_ChIP-Seq_ESCs_Human1.03434467
150RUNX2_22187159_ChIP-Seq_PCA_Human1.02908558
151FOXH1_21741376_ChIP-Seq_EPCs_Human1.02658578
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01938644
153TCF4_22108803_ChIP-Seq_LS180_Human1.01480556
154BCAT_22108803_ChIP-Seq_LS180_Human1.00064575
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99509220
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98868787
157MYC_19829295_ChIP-Seq_ESCs_Human0.98510922
158JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97206669
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.97202151
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97175746
161RXR_22158963_ChIP-Seq_LIVER_Mouse0.96401463
162DCP1A_22483619_ChIP-Seq_HELA_Human0.96278725
163TBL1_22424771_ChIP-Seq_293T_Human0.95654068
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.95471962
165CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95303026
166FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95137257
167CHD1_26751641_Chip-Seq_LNCaP_Human0.95012778
168ETV1_20927104_ChIP-Seq_GIST48_Human0.94175191
169PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94118943
170ERA_21632823_ChIP-Seq_H3396_Human0.93762968
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93759720
172SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93445692
173SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92067337
174PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91802861
175SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91670060
176ELK1_19687146_ChIP-ChIP_HELA_Human0.91011100
177EGR1_19374776_ChIP-ChIP_THP-1_Human0.90921146
178SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89391595
179SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88600698
180DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88467152
181POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86300508
182NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82666704
183ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82529928
184ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81287982
185ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79781733
186HOXB7_26014856_ChIP-Seq_BT474_Human0.78801390
187SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75036276
188DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74946434
189STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74408679
190RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72651399
191TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.70663844

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.76780672
2MP0002139_abnormal_hepatobiliary_system3.17991672
3MP0008057_abnormal_DNA_replication2.96690428
4MP0002877_abnormal_melanocyte_morpholog2.66459774
5MP0002396_abnormal_hematopoietic_system2.59551312
6MP0010094_abnormal_chromosome_stability2.49597827
7MP0003950_abnormal_plasma_membrane2.45990176
8MP0008007_abnormal_cellular_replicative2.41223019
9MP0009697_abnormal_copulation2.36632315
10MP0002234_abnormal_pharynx_morphology2.35099488
11MP0004147_increased_porphyrin_level2.31275485
12MP0005085_abnormal_gallbladder_physiolo2.31179309
13MP0003077_abnormal_cell_cycle2.29643718
14MP0005365_abnormal_bile_salt2.29618982
15MP0005410_abnormal_fertilization2.29412059
16MP0002837_dystrophic_cardiac_calcinosis2.27251564
17MP0004084_abnormal_cardiac_muscle2.13716740
18MP0003111_abnormal_nucleus_morphology2.13697085
19MP0003195_calcinosis2.12101300
20MP0002102_abnormal_ear_morphology2.10791848
21MP0001188_hyperpigmentation2.09300061
22MP0005551_abnormal_eye_electrophysiolog2.07324554
23MP0003693_abnormal_embryo_hatching2.02234424
24MP0004130_abnormal_muscle_cell1.98798650
25MP0008877_abnormal_DNA_methylation1.96422371
26MP0003123_paternal_imprinting1.95777092
27MP0006036_abnormal_mitochondrial_physio1.90165171
28MP0004957_abnormal_blastocyst_morpholog1.83242329
29MP0004036_abnormal_muscle_relaxation1.81225639
30MP0002009_preneoplasia1.80616971
31MP0008058_abnormal_DNA_repair1.72541340
32MP0000749_muscle_degeneration1.72172008
33MP0003698_abnormal_male_reproductive1.58769051
34MP0002269_muscular_atrophy1.58185316
35MP0002277_abnormal_respiratory_mucosa1.57002096
36MP0003221_abnormal_cardiomyocyte_apopto1.56800519
37MP0003011_delayed_dark_adaptation1.56512548
38MP0005646_abnormal_pituitary_gland1.56123468
39MP0003806_abnormal_nucleotide_metabolis1.54697924
40MP0000631_abnormal_neuroendocrine_gland1.52463424
41MP0004142_abnormal_muscle_tone1.50681680
42MP0006292_abnormal_olfactory_placode1.50399544
43MP0004782_abnormal_surfactant_physiolog1.50152320
44MP0002106_abnormal_muscle_physiology1.43705991
45MP0004087_abnormal_muscle_fiber1.43384739
46MP0001968_abnormal_touch/_nociception1.43078091
47MP0006138_congestive_heart_failure1.42233961
48MP0003787_abnormal_imprinting1.42092771
49MP0004233_abnormal_muscle_weight1.41954991
50MP0004264_abnormal_extraembryonic_tissu1.41926096
51MP0003943_abnormal_hepatobiliary_system1.40508168
52MP0002876_abnormal_thyroid_physiology1.39684786
53MP0005385_cardiovascular_system_phenoty1.38207077
54MP0001544_abnormal_cardiovascular_syste1.38207077
55MP0003567_abnormal_fetal_cardiomyocyte1.37731977
56MP0005389_reproductive_system_phenotype1.37607220
57MP0000681_abnormal_thyroid_gland1.35636365
58MP0002332_abnormal_exercise_endurance1.33667963
59MP0005666_abnormal_adipose_tissue1.32762468
60MP0001764_abnormal_homeostasis1.32323685
61MP0009780_abnormal_chondrocyte_physiolo1.31955247
62MP0005670_abnormal_white_adipose1.31838849
63MP0005620_abnormal_muscle_contractility1.31764237
64MP0003984_embryonic_growth_retardation1.30568388
65MP0001672_abnormal_embryogenesis/_devel1.28698013
66MP0005380_embryogenesis_phenotype1.28698013
67MP0004185_abnormal_adipocyte_glucose1.28055541
68MP0000751_myopathy1.27768918
69MP0001666_abnormal_nutrient_absorption1.27102071
70MP0009250_abnormal_appendicular_skeleto1.24814426
71MP0002088_abnormal_embryonic_growth/wei1.24439570
72MP0004215_abnormal_myocardial_fiber1.24392477
73MP0003656_abnormal_erythrocyte_physiolo1.22433501
74MP0010307_abnormal_tumor_latency1.21671178
75MP0001119_abnormal_female_reproductive1.21429356
76MP0004145_abnormal_muscle_electrophysio1.21051928
77MP0002163_abnormal_gland_morphology1.20858503
78MP0002108_abnormal_muscle_morphology1.18559799
79MP0003718_maternal_effect1.17715192
80MP0002132_abnormal_respiratory_system1.17130786
81MP0010630_abnormal_cardiac_muscle1.14776326
82MP0002972_abnormal_cardiac_muscle1.14101241
83MP0000049_abnormal_middle_ear1.13951696
84MP0005369_muscle_phenotype1.13680171
85MP0001730_embryonic_growth_arrest1.12669571
86MP0009672_abnormal_birth_weight1.11870439
87MP0000427_abnormal_hair_cycle1.11279108
88MP0000350_abnormal_cell_proliferation1.10329765
89MP0002249_abnormal_larynx_morphology1.09832286
90MP0009046_muscle_twitch1.08268969
91MP0001986_abnormal_taste_sensitivity1.07863556
92MP0005408_hypopigmentation1.07182666
93MP0001270_distended_abdomen1.06323669
94MP0000013_abnormal_adipose_tissue1.05937740
95MP0006276_abnormal_autonomic_nervous1.05328578
96MP0005330_cardiomyopathy1.04637094
97MP0001145_abnormal_male_reproductive1.03974418
98MP0005645_abnormal_hypothalamus_physiol1.03492240
99MP0001545_abnormal_hematopoietic_system1.01463692
100MP0005397_hematopoietic_system_phenotyp1.01463692
101MP0010329_abnormal_lipoprotein_level0.98487503
102MP0000372_irregular_coat_pigmentation0.95558608
103MP0002138_abnormal_hepatobiliary_system0.94829325
104MP0004484_altered_response_of0.94689644
105MP0000569_abnormal_digit_pigmentation0.92041067
106MP0002272_abnormal_nervous_system0.91686227
107MP0005386_behavior/neurological_phenoty0.90840985
108MP0004924_abnormal_behavior0.90840985
109MP0001697_abnormal_embryo_size0.90575281
110MP0003186_abnormal_redox_activity0.90175551
111MP0000750_abnormal_muscle_regeneration0.90162835
112MP0002127_abnormal_cardiovascular_syste0.89873861
113MP0001501_abnormal_sleep_pattern0.89849878
114MP0003252_abnormal_bile_duct0.88430646
115MP0000003_abnormal_adipose_tissue0.88162914
116MP0005220_abnormal_exocrine_pancreas0.87600002
117MP0004270_analgesia0.86341615
118MP0000566_synostosis0.85494520
119MP0005647_abnormal_sex_gland0.85022427
120MP0008775_abnormal_heart_ventricle0.84626436
121MP0003699_abnormal_female_reproductive0.84174163
122MP0000747_muscle_weakness0.83554434
123MP0000759_abnormal_skeletal_muscle0.83003705
124MP0003121_genomic_imprinting0.82728105
125MP0002210_abnormal_sex_determination0.82468774
126MP0005266_abnormal_metabolism0.82442953
127MP0001929_abnormal_gametogenesis0.82369145
128MP0002733_abnormal_thermal_nociception0.81948277
129MP0005332_abnormal_amino_acid0.80661515
130MP0001502_abnormal_circadian_rhythm0.80314856
131MP0004808_abnormal_hematopoietic_stem0.80219404
132MP0003959_abnormal_lean_body0.80129299
133MP0004885_abnormal_endolymph0.79834950
134MP0002086_abnormal_extraembryonic_tissu0.79694699
135MP0000733_abnormal_muscle_development0.79679103
136MP0000015_abnormal_ear_pigmentation0.79520112
137MP0005253_abnormal_eye_physiology0.79155949
138MP0002736_abnormal_nociception_after0.78906228
139MP0000266_abnormal_heart_morphology0.78320686
140MP0000653_abnormal_sex_gland0.78215174
141MP0003705_abnormal_hypodermis_morpholog0.76800617
142MP0008995_early_reproductive_senescence0.76450522
143MP0000778_abnormal_nervous_system0.76321961
144MP0000678_abnormal_parathyroid_gland0.75479835
145MP0006035_abnormal_mitochondrial_morpho0.75210939
146MP0002160_abnormal_reproductive_system0.74287564
147MP0003786_premature_aging0.74218289
148MP0009703_decreased_birth_body0.72884070
149MP0002161_abnormal_fertility/fecundity0.72653635
150MP0000516_abnormal_urinary_system0.72271394
151MP0005367_renal/urinary_system_phenotyp0.72271394
152MP0000313_abnormal_cell_death0.72240529
153MP0003137_abnormal_impulse_conducting0.72096051
154MP0006072_abnormal_retinal_apoptosis0.71263219
155MP0001919_abnormal_reproductive_system0.70867974
156MP0005379_endocrine/exocrine_gland_phen0.70763307
157MP0000955_abnormal_spinal_cord0.70707885
158MP0009745_abnormal_behavioral_response0.70212093
159MP0002067_abnormal_sensory_capabilities0.69476948
160MP0002752_abnormal_somatic_nervous0.67002634

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.57542047
2Exercise-induced muscle cramps (HP:0003710)4.38507528
3Hyperglycinuria (HP:0003108)3.92530454
4Papillary thyroid carcinoma (HP:0002895)3.81004373
5Type 1 muscle fiber predominance (HP:0003803)3.68158544
6Myoglobinuria (HP:0002913)3.57810670
7Birth length less than 3rd percentile (HP:0003561)3.55133999
8Hyperkalemia (HP:0002153)3.50256516
9Hyperglycinemia (HP:0002154)3.23407162
10Rhabdomyolysis (HP:0003201)3.05229502
11Abnormality of glycine metabolism (HP:0010895)2.97684226
12Abnormality of serine family amino acid metabolism (HP:0010894)2.97684226
13Hypoglycemic coma (HP:0001325)2.94176465
14Spinal cord lesions (HP:0100561)2.91919819
15Syringomyelia (HP:0003396)2.91919819
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90840178
17Limb hypertonia (HP:0002509)2.90803456
18Progressive inability to walk (HP:0002505)2.89596797
19Irregular epiphyses (HP:0010582)2.87950679
20Pancreatic cysts (HP:0001737)2.81443076
21Thyroid carcinoma (HP:0002890)2.80614470
22Distal arthrogryposis (HP:0005684)2.79950909
23Abnormality of the fingertips (HP:0001211)2.77425744
24Myotonia (HP:0002486)2.76689518
25Neoplasm of the adrenal gland (HP:0100631)2.70909173
26Round ear (HP:0100830)2.67925829
27Molar tooth sign on MRI (HP:0002419)2.66061096
28Abnormality of midbrain morphology (HP:0002418)2.66061096
29Abnormality of the renal collecting system (HP:0004742)2.63039961
30Renal cortical cysts (HP:0000803)2.62189808
31Duplicated collecting system (HP:0000081)2.60645296
32Rimmed vacuoles (HP:0003805)2.59511555
33Nephronophthisis (HP:0000090)2.58270266
34Hyperglycemia (HP:0003074)2.57281626
35Meningioma (HP:0002858)2.56954562
36Pancreatic fibrosis (HP:0100732)2.55491275
37Tetany (HP:0001281)2.54930810
38Abnormality of the anterior horn cell (HP:0006802)2.53656695
39Degeneration of anterior horn cells (HP:0002398)2.53656695
40Attenuation of retinal blood vessels (HP:0007843)2.52287172
41Neonatal hypoglycemia (HP:0001998)2.50923223
42Medial flaring of the eyebrow (HP:0010747)2.49014790
43True hermaphroditism (HP:0010459)2.49013442
44Genetic anticipation (HP:0003743)2.49002838
45Type II lissencephaly (HP:0007260)2.47049885
46Malignant hyperthermia (HP:0002047)2.43024671
47Abnormality of the left ventricular outflow tract (HP:0011103)2.42657119
48Subaortic stenosis (HP:0001682)2.42657119
49Neoplasm of the peripheral nervous system (HP:0100007)2.42213028
50Hyperammonemia (HP:0001987)2.41077904
51Hypoplastic ischia (HP:0003175)2.39830257
52Absent phalangeal crease (HP:0006109)2.39310294
53Cystic hygroma (HP:0000476)2.36990220
54Abnormal rod and cone electroretinograms (HP:0008323)2.36776277
55EMG: myopathic abnormalities (HP:0003458)2.36630213
56Abnormality of the ischium (HP:0003174)2.36318224
57Chromsome breakage (HP:0040012)2.35645637
58Muscle fiber inclusion bodies (HP:0100299)2.30923622
59Polydipsia (HP:0001959)2.30008401
60Abnormal drinking behavior (HP:0030082)2.30008401
61Ectopic kidney (HP:0000086)2.29716401
62Areflexia of lower limbs (HP:0002522)2.27669119
63Ketoacidosis (HP:0001993)2.26913303
64Congenital stationary night blindness (HP:0007642)2.25686935
65Muscle stiffness (HP:0003552)2.25243549
66Gout (HP:0001997)2.24339642
67Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24206520
68Abnormal number of incisors (HP:0011064)2.24083904
69Urinary bladder sphincter dysfunction (HP:0002839)2.23992200
70Truncal obesity (HP:0001956)2.23370687
71Volvulus (HP:0002580)2.23188619
72Constricted visual fields (HP:0001133)2.22325109
73Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.22036574
74Double outlet right ventricle (HP:0001719)2.21412360
75Congenital malformation of the right heart (HP:0011723)2.21412360
76Abnormality of fatty-acid metabolism (HP:0004359)2.20981750
77Lissencephaly (HP:0001339)2.20883648
78Hypoplastic left heart (HP:0004383)2.20688112
79Abnormality of DNA repair (HP:0003254)2.20671143
80Abnormality of the phalanges of the 5th finger (HP:0004213)2.18151898
81Hypoplastic heart (HP:0001961)2.16273849
82Hyperventilation (HP:0002883)2.15666495
83Long clavicles (HP:0000890)2.15570757
84Nemaline bodies (HP:0003798)2.14299884
85Impulsivity (HP:0100710)2.14114806
86Carpal bone hypoplasia (HP:0001498)2.13051993
87Small hand (HP:0200055)2.11698996
88Abnormality of the renal medulla (HP:0100957)2.08593263
89Mesangial abnormality (HP:0001966)2.07192701
90Decreased central vision (HP:0007663)2.06040619
91Neoplasm of the adrenal cortex (HP:0100641)2.05887016
92Deep philtrum (HP:0002002)2.05867835
93Anterior segment dysgenesis (HP:0007700)2.05721948
94Anhidrosis (HP:0000970)2.05302479
95Bony spicule pigmentary retinopathy (HP:0007737)2.03051777
96Calf muscle hypertrophy (HP:0008981)2.02033659
97Toxemia of pregnancy (HP:0100603)2.01635420
98Azoospermia (HP:0000027)2.01620460
99Tinnitus (HP:0000360)2.00726606
100Abnormality of lateral ventricle (HP:0030047)2.00474602
101Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99652747
102Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.98912916
103Inability to walk (HP:0002540)1.98840099
104Insulin-resistant diabetes mellitus (HP:0000831)1.98835289
105Abnormality of the calf musculature (HP:0001430)1.98408628
106Abnormal spermatogenesis (HP:0008669)1.98402525
107Acute myeloid leukemia (HP:0004808)1.98301834
108Abnormality of the renal cortex (HP:0011035)1.97162967
109Hyperuricemia (HP:0002149)1.94204107
110Increased purine levels (HP:0004368)1.94204107
111Decreased circulating renin level (HP:0003351)1.92209118
112Ketosis (HP:0001946)1.91997010
113Ulnar deviation of the wrist (HP:0003049)1.91668746
114Bundle branch block (HP:0011710)1.90740118
115Fetal akinesia sequence (HP:0001989)1.90187433
116Tubular atrophy (HP:0000092)1.89777942
117Sclerocornea (HP:0000647)1.89601683
118Abnormality of the aortic arch (HP:0012303)1.89596830
119Cerebellar dysplasia (HP:0007033)1.87236844
120Asymmetric septal hypertrophy (HP:0001670)1.86347686
121Abnormality of serum amino acid levels (HP:0003112)1.85914826
122Type 2 muscle fiber atrophy (HP:0003554)1.85366613
123Amblyopia (HP:0000646)1.84372734
124Tetraplegia (HP:0002445)1.83906493
125Muscle fibrillation (HP:0010546)1.82760686
126Abnormality of chromosome stability (HP:0003220)1.82490058
127Tongue fasciculations (HP:0001308)1.82090101
128Abnormality of the nasal septum (HP:0000419)1.81958142
129Abnormality of potassium homeostasis (HP:0011042)1.81867477
130Bulbous nose (HP:0000414)1.81597385
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81045999
132Abnormality of alanine metabolism (HP:0010916)1.81045999
133Hyperalaninemia (HP:0003348)1.81045999
134Increased connective tissue (HP:0009025)1.80848141
135Atrial fibrillation (HP:0005110)1.80194266
136Prominent metopic ridge (HP:0005487)1.79686092
137Preauricular pit (HP:0004467)1.79382965
138Periauricular skin pits (HP:0100277)1.79382965
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79262923
140Abnormality of the metopic suture (HP:0005556)1.78176361
141Muscle fiber splitting (HP:0003555)1.77295046
142Broad-based gait (HP:0002136)1.76976181
143Heart block (HP:0012722)1.76635285
144Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76520291
145Muscle hypertrophy of the lower extremities (HP:0008968)1.76498494
146Cutaneous melanoma (HP:0012056)1.76253468
147Atrioventricular block (HP:0001678)1.75458688
148Nausea (HP:0002018)1.75207818
149Supraventricular tachycardia (HP:0004755)1.75116046
150Selective tooth agenesis (HP:0001592)1.74920112
151Colon cancer (HP:0003003)1.74117294
152Pancreatic islet-cell hyperplasia (HP:0004510)1.73949255
153Benign neoplasm of the central nervous system (HP:0100835)1.73785883
154Abnormal finger flexion creases (HP:0006143)1.73102130
155Large hands (HP:0001176)1.72399134
156Dicarboxylic aciduria (HP:0003215)1.71298460
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71298460
158Lipoatrophy (HP:0100578)1.70800566
159Progressive cerebellar ataxia (HP:0002073)1.70531984
160Left ventricular hypertrophy (HP:0001712)1.70369115
161Primary atrial arrhythmia (HP:0001692)1.70323579
162Broad palm (HP:0001169)1.69066121
163Aplasia/Hypoplasia of the patella (HP:0006498)1.68299565
164Hip contracture (HP:0003273)1.67751190
165Generalized aminoaciduria (HP:0002909)1.67370323
166Polyuria (HP:0000103)1.67054122
167Hypoplastic iliac wings (HP:0002866)1.65591456
168Medulloblastoma (HP:0002885)1.65090470
169Supraventricular arrhythmia (HP:0005115)1.64620804
170Neoplasm of the small intestine (HP:0100833)1.64448711
171Patellar aplasia (HP:0006443)1.64045235
172Poor speech (HP:0002465)1.62768168
173Osteomalacia (HP:0002749)1.62759172
174Oligomenorrhea (HP:0000876)1.62639331
175Multiple enchondromatosis (HP:0005701)1.60855872
176Dilated cardiomyopathy (HP:0001644)1.60500441
177Abnormality of chromosome segregation (HP:0002916)1.60078088
178Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.59967620
179Hypochromic microcytic anemia (HP:0004840)1.59351622
180Aplastic anemia (HP:0001915)1.58855406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.54014119
2STK244.13458331
3STK38L3.30422210
4TAF13.18603980
5PNCK3.08428203
6STK32.92723713
7MARK12.83995013
8AKT32.73194781
9PRKD32.61656068
10NEK12.60982141
11STK162.51662835
12NUAK12.47512208
13BCKDK2.41535425
14PRPF4B2.34148087
15TAOK32.32136491
16BRSK22.27015187
17SGK22.20453906
18PINK12.14044487
19ERBB32.09779629
20BRSK12.01962031
21CDC71.97888444
22CDK81.95368100
23WNK41.94030525
24CAMK1G1.93669448
25PDK41.92002187
26PDK31.92002187
27MAPK131.88863787
28PLK41.86387508
29ZAK1.74891664
30SGK31.72847564
31PLK31.70373803
32BMPR21.70309476
33NEK91.67242336
34LATS11.60518012
35ACVR1B1.53921656
36LATS21.53838645
37EIF2AK11.48383348
38SIK31.46848357
39GRK11.46329883
40OBSCN1.42165386
41TTK1.40097977
42TNIK1.39162876
43MAP2K31.34765720
44TXK1.32562222
45ADRBK21.27549340
46MAP3K61.21481797
47MUSK1.21081241
48MAP3K111.16591280
49PKN21.16071527
50NEK21.13761414
51RPS6KB11.11729115
52DAPK21.10776105
53MAP3K41.10337761
54SRPK11.09076598
55NEK61.08596389
56SGK2231.06675763
57SGK4941.06675763
58PLK11.04848723
59MAP3K31.02009858
60PDK21.01029600
61PLK21.00751180
62PIK3CG0.96869524
63VRK20.95704702
64CAMK10.93860179
65MKNK20.93821531
66MAPK120.93419453
67MAP3K130.91624435
68MAP2K70.90774832
69WNK10.90685048
70FRK0.90115707
71ATR0.90080947
72STK390.90052071
73MAPK110.88083318
74WNK30.86756965
75PRKAA10.86692418
76TRIB30.86367645
77MAP2K40.85383542
78BRAF0.85063444
79MKNK10.84930847
80IRAK10.84861621
81NLK0.82870872
82EEF2K0.82769841
83MAPKAPK50.82468836
84FLT30.80659607
85TIE10.78041382
86YES10.77541282
87PIM10.76224176
88CDK40.73726829
89MAP4K20.73158301
90CAMK1D0.71631835
91CCNB10.71232354
92BMPR1B0.71166784
93RPS6KA60.68400350
94EPHB20.67622327
95EIF2AK30.67297147
96PIK3CA0.67054167
97RPS6KC10.66977130
98RPS6KL10.66977130
99MARK30.66462142
100ATM0.65161884
101WEE10.64853845
102TAOK10.64484533
103ADRBK10.64422859
104CAMK40.64277105
105CHEK10.64043047
106BUB10.62260788
107MAPK70.61062740
108PHKG20.58629684
109PHKG10.58629684
110TAOK20.57383959
111OXSR10.57189003
112VRK10.56526675
113CSNK1G10.55282261
114TEC0.55094612
115TRPM70.53967759
116MAP3K70.53396340
117MAP3K140.53258266
118MAP2K60.52521985
119CDK190.51904455
120STK380.51337994
121MAP3K50.50352575
122CDK70.49412164
123CDK20.47989596
124DYRK20.47318886
125AURKA0.47018987
126CHUK0.46503885
127AURKB0.46095929
128CHEK20.45805560
129TRIM280.44629483
130INSRR0.44423699
131PRKAA20.44385213
132DAPK10.44286146
133TSSK60.44278260
134PAK30.44084816
135RPS6KA20.43427066
136NTRK20.43326522
137PRKCZ0.43294989
138RPS6KA40.42303640
139KSR20.42061979
140PRKACA0.39331214
141CDK60.39268360
142DYRK30.39131881
143DMPK0.37697827
144FGFR30.36500836
145STK110.36072564
146RAF10.35985980
147MAP2K10.35893708
148TNK20.35090379
149RPS6KA10.34704125
150PRKG10.34688948
151KSR10.34052176
152BCR0.33421427
153CSNK1A1L0.32665479
154PRKCE0.32411663
155MAPKAPK30.32138064
156MELK0.31949420
157PRKCH0.31944314
158CSNK1G20.30989321
159CDK30.29250896

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.03663481
2Sulfur relay system_Homo sapiens_hsa041223.98638856
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.27739642
4Phototransduction_Homo sapiens_hsa047443.22646663
5Propanoate metabolism_Homo sapiens_hsa006402.93851051
6Vitamin B6 metabolism_Homo sapiens_hsa007502.92036528
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49987644
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38660952
9Fatty acid degradation_Homo sapiens_hsa000712.27176593
10Cell cycle_Homo sapiens_hsa041102.26735942
11Cardiac muscle contraction_Homo sapiens_hsa042602.25283984
12DNA replication_Homo sapiens_hsa030302.22850628
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16364264
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14407477
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11956318
16Dorso-ventral axis formation_Homo sapiens_hsa043202.04414186
17RNA polymerase_Homo sapiens_hsa030202.03734189
18RNA degradation_Homo sapiens_hsa030182.01680179
19Base excision repair_Homo sapiens_hsa034101.96612429
20Fatty acid metabolism_Homo sapiens_hsa012121.90934395
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.88476796
22Mismatch repair_Homo sapiens_hsa034301.87644142
23Carbon metabolism_Homo sapiens_hsa012001.84973732
24One carbon pool by folate_Homo sapiens_hsa006701.82080181
25RNA transport_Homo sapiens_hsa030131.74705223
26Nitrogen metabolism_Homo sapiens_hsa009101.73937875
27Biosynthesis of amino acids_Homo sapiens_hsa012301.73234488
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68714707
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67972595
30Linoleic acid metabolism_Homo sapiens_hsa005911.64750133
31Homologous recombination_Homo sapiens_hsa034401.61070368
32Morphine addiction_Homo sapiens_hsa050321.55876752
33Ether lipid metabolism_Homo sapiens_hsa005651.55084255
34Basal transcription factors_Homo sapiens_hsa030221.54448668
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49363774
36Parkinsons disease_Homo sapiens_hsa050121.46489528
37mRNA surveillance pathway_Homo sapiens_hsa030151.41491433
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.39953497
39Thyroid cancer_Homo sapiens_hsa052161.38113929
40Pyruvate metabolism_Homo sapiens_hsa006201.35510775
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.29482654
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28223564
43Long-term depression_Homo sapiens_hsa047301.27277231
44Fatty acid biosynthesis_Homo sapiens_hsa000611.27077580
45Oxidative phosphorylation_Homo sapiens_hsa001901.26828639
46Insulin secretion_Homo sapiens_hsa049111.23538250
47Oxytocin signaling pathway_Homo sapiens_hsa049211.23003075
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22452757
49Ovarian steroidogenesis_Homo sapiens_hsa049131.21330451
50beta-Alanine metabolism_Homo sapiens_hsa004101.20928175
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17072212
52Circadian rhythm_Homo sapiens_hsa047101.16272380
53Calcium signaling pathway_Homo sapiens_hsa040201.15159537
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13723005
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13197739
56Purine metabolism_Homo sapiens_hsa002301.12808230
57Hedgehog signaling pathway_Homo sapiens_hsa043401.11868108
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09995885
59Nucleotide excision repair_Homo sapiens_hsa034201.09410589
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07861275
61Glucagon signaling pathway_Homo sapiens_hsa049221.06468248
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.05698235
63Nicotine addiction_Homo sapiens_hsa050331.03628581
64Arginine biosynthesis_Homo sapiens_hsa002201.02653377
65Oocyte meiosis_Homo sapiens_hsa041141.02461326
66Selenocompound metabolism_Homo sapiens_hsa004501.02166359
67PPAR signaling pathway_Homo sapiens_hsa033200.99318155
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98601389
69Serotonergic synapse_Homo sapiens_hsa047260.97496072
70Pyrimidine metabolism_Homo sapiens_hsa002400.97140927
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97067555
72Fructose and mannose metabolism_Homo sapiens_hsa000510.97061686
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.96098803
74GABAergic synapse_Homo sapiens_hsa047270.95921979
75Taste transduction_Homo sapiens_hsa047420.95679979
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95113995
77Circadian entrainment_Homo sapiens_hsa047130.94367968
78Starch and sucrose metabolism_Homo sapiens_hsa005000.93919328
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92892409
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90911677
81Peroxisome_Homo sapiens_hsa041460.89645332
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.89299115
83Non-homologous end-joining_Homo sapiens_hsa034500.89002599
84Huntingtons disease_Homo sapiens_hsa050160.88729625
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88080411
86Lysine degradation_Homo sapiens_hsa003100.84826611
87Insulin resistance_Homo sapiens_hsa049310.83925325
88Insulin signaling pathway_Homo sapiens_hsa049100.83854782
89MAPK signaling pathway_Homo sapiens_hsa040100.83235709
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83113744
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82830979
92cAMP signaling pathway_Homo sapiens_hsa040240.80140080
93Endometrial cancer_Homo sapiens_hsa052130.79623093
94Pentose phosphate pathway_Homo sapiens_hsa000300.75683982
95Mineral absorption_Homo sapiens_hsa049780.75432217
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73664686
97Tryptophan metabolism_Homo sapiens_hsa003800.70651012
98Galactose metabolism_Homo sapiens_hsa000520.70151547
99AMPK signaling pathway_Homo sapiens_hsa041520.69873699
100Alzheimers disease_Homo sapiens_hsa050100.69223613
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65527247
102Dopaminergic synapse_Homo sapiens_hsa047280.65328626
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65243828
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63763640
105mTOR signaling pathway_Homo sapiens_hsa041500.63000626
106Fanconi anemia pathway_Homo sapiens_hsa034600.60779075
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60143426
108Cholinergic synapse_Homo sapiens_hsa047250.59895424
109Gastric acid secretion_Homo sapiens_hsa049710.59568147
110Hippo signaling pathway_Homo sapiens_hsa043900.58953192
111Glutamatergic synapse_Homo sapiens_hsa047240.58839628
112FoxO signaling pathway_Homo sapiens_hsa040680.58729064
113Caffeine metabolism_Homo sapiens_hsa002320.58186331
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57938603
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.56339767
116Glycerolipid metabolism_Homo sapiens_hsa005610.55722495
117Spliceosome_Homo sapiens_hsa030400.53869531
118TGF-beta signaling pathway_Homo sapiens_hsa043500.53357600
119Sulfur metabolism_Homo sapiens_hsa009200.52947533
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52468827
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.51111014
122Basal cell carcinoma_Homo sapiens_hsa052170.50785603
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50640117
124Non-small cell lung cancer_Homo sapiens_hsa052230.50550664
125Butanoate metabolism_Homo sapiens_hsa006500.48137577
126p53 signaling pathway_Homo sapiens_hsa041150.46446480
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44617917
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.43699854
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42217886
130Olfactory transduction_Homo sapiens_hsa047400.41557989
131Herpes simplex infection_Homo sapiens_hsa051680.41077554
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41018972
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39621516
134Salivary secretion_Homo sapiens_hsa049700.39451327
135Inositol phosphate metabolism_Homo sapiens_hsa005620.39071635
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37991427
137Cocaine addiction_Homo sapiens_hsa050300.36281779
138Arginine and proline metabolism_Homo sapiens_hsa003300.34642998
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34015256
140Small cell lung cancer_Homo sapiens_hsa052220.33300749
141Dilated cardiomyopathy_Homo sapiens_hsa054140.33216143
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.32793321
143Melanoma_Homo sapiens_hsa052180.32378617
144ABC transporters_Homo sapiens_hsa020100.32148118
145HTLV-I infection_Homo sapiens_hsa051660.31671096
146Folate biosynthesis_Homo sapiens_hsa007900.31453577
147Platelet activation_Homo sapiens_hsa046110.29818093
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29587412
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29529676
150Melanogenesis_Homo sapiens_hsa049160.28849096
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28648086
152Colorectal cancer_Homo sapiens_hsa052100.27936933
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27187839
154Prolactin signaling pathway_Homo sapiens_hsa049170.27117216
155Phenylalanine metabolism_Homo sapiens_hsa003600.26008903
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.25722005
157Regulation of autophagy_Homo sapiens_hsa041400.25502249

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