GID8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.82018156
2protoporphyrinogen IX biosynthetic process (GO:0006782)5.26599778
3viral transcription (GO:0019083)4.96304891
4translational termination (GO:0006415)4.83565298
5folic acid-containing compound biosynthetic process (GO:0009396)4.81956346
6heme biosynthetic process (GO:0006783)4.58045179
7porphyrin-containing compound biosynthetic process (GO:0006779)4.45924094
8mitotic sister chromatid cohesion (GO:0007064)4.43798527
9mitotic chromosome condensation (GO:0007076)4.36974977
10translational elongation (GO:0006414)4.30646767
11protein complex localization (GO:0031503)4.11716262
12nuclear pore complex assembly (GO:0051292)4.06634492
13ribosomal small subunit biogenesis (GO:0042274)4.05780445
14establishment of integrated proviral latency (GO:0075713)3.96987922
15maturation of SSU-rRNA (GO:0030490)3.93553176
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86518737
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.86029556
18tetrapyrrole biosynthetic process (GO:0033014)3.85490444
19cellular protein complex localization (GO:0034629)3.82105543
20heme metabolic process (GO:0042168)3.81713577
21DNA strand elongation involved in DNA replication (GO:0006271)3.81083525
22protein targeting to ER (GO:0045047)3.78194623
23porphyrin-containing compound metabolic process (GO:0006778)3.77450767
24translational initiation (GO:0006413)3.75839604
25telomere maintenance via semi-conservative replication (GO:0032201)3.74485669
26cotranslational protein targeting to membrane (GO:0006613)3.73830718
27heterochromatin organization (GO:0070828)3.73470487
28viral life cycle (GO:0019058)3.70933606
29regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.64881334
30DNA strand elongation (GO:0022616)3.63440422
31cellular protein complex disassembly (GO:0043624)3.63432468
32glycine metabolic process (GO:0006544)3.62666231
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60959456
34DNA synthesis involved in DNA repair (GO:0000731)3.60888904
35DNA topological change (GO:0006265)3.58761636
36ribosomal small subunit assembly (GO:0000028)3.58692092
37DNA replication initiation (GO:0006270)3.57940515
38DNA unwinding involved in DNA replication (GO:0006268)3.56049474
39protein localization to endoplasmic reticulum (GO:0070972)3.52027558
40DNA replication checkpoint (GO:0000076)3.49318503
41lysine catabolic process (GO:0006554)3.45754313
42lysine metabolic process (GO:0006553)3.45754313
43protein localization to chromosome, centromeric region (GO:0071459)3.45699419
44tetrahydrofolate metabolic process (GO:0046653)3.40376028
45pre-miRNA processing (GO:0031054)3.39918396
46pteridine-containing compound biosynthetic process (GO:0042559)3.35119151
47regulation of histone H3-K27 methylation (GO:0061085)3.34652635
48maternal placenta development (GO:0001893)3.32450688
49regulation of RNA export from nucleus (GO:0046831)3.32175627
50folic acid metabolic process (GO:0046655)3.30652737
51regulation of gene silencing by miRNA (GO:0060964)3.30263483
52regulation of gene silencing by RNA (GO:0060966)3.30263483
53regulation of posttranscriptional gene silencing (GO:0060147)3.30263483
54COPI coating of Golgi vesicle (GO:0048205)3.26116845
55Golgi transport vesicle coating (GO:0048200)3.26116845
56protein complex disassembly (GO:0043241)3.25225043
57mitotic metaphase plate congression (GO:0007080)3.20071067
58cysteine metabolic process (GO:0006534)3.18746866
59mRNA stabilization (GO:0048255)3.18227399
60RNA stabilization (GO:0043489)3.18227399
61protein localization to microtubule (GO:0035372)3.15398794
62DNA deamination (GO:0045006)3.13805800
63negative regulation of fatty acid biosynthetic process (GO:0045717)3.09334672
64regulation of centriole replication (GO:0046599)3.09287497
65formation of translation preinitiation complex (GO:0001731)3.08866741
66ribosomal large subunit biogenesis (GO:0042273)3.08643607
67telomere maintenance via recombination (GO:0000722)3.07362419
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04374575
69macromolecular complex disassembly (GO:0032984)3.03535440
70regulation of transcription from RNA polymerase I promoter (GO:0006356)3.03513010
71imidazole-containing compound metabolic process (GO:0052803)3.02652178
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.00991482
73mitotic sister chromatid segregation (GO:0000070)3.00737875
74hepatocyte apoptotic process (GO:0097284)2.99488579
75DNA duplex unwinding (GO:0032508)2.98422061
76regulation of nucleobase-containing compound transport (GO:0032239)2.97346124
77sister chromatid segregation (GO:0000819)2.95964972
78spliceosomal tri-snRNP complex assembly (GO:0000244)2.95110422
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94273381
80DNA replication-dependent nucleosome organization (GO:0034723)2.93206153
81DNA replication-dependent nucleosome assembly (GO:0006335)2.93206153
82regulation of water loss via skin (GO:0033561)2.91797266
83protein-DNA complex disassembly (GO:0032986)2.90269277
84nucleosome disassembly (GO:0006337)2.90269277
85mitotic nuclear envelope disassembly (GO:0007077)2.89773785
86ear development (GO:0043583)2.89275419
87serine family amino acid metabolic process (GO:0009069)2.89036787
88positive regulation of keratinocyte differentiation (GO:0045618)2.88769022
89mitotic recombination (GO:0006312)2.88662793
90telomere maintenance via telomere lengthening (GO:0010833)2.87059882
91establishment of viral latency (GO:0019043)2.84237896
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84194987
93L-phenylalanine metabolic process (GO:0006558)2.84194987
94NADPH regeneration (GO:0006740)2.83614800
95kynurenine metabolic process (GO:0070189)2.83309607
96desmosome organization (GO:0002934)2.83281639
97L-serine metabolic process (GO:0006563)2.82949804
98positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.82803958
99positive regulation of cell cycle G2/M phase transition (GO:1902751)2.82803958
100DNA geometric change (GO:0032392)2.81070081
101positive regulation of chromosome segregation (GO:0051984)2.80942349
102nuclear-transcribed mRNA catabolic process (GO:0000956)2.80868382
103membrane disassembly (GO:0030397)2.80387437
104nuclear envelope disassembly (GO:0051081)2.80387437
105ribonucleoprotein complex biogenesis (GO:0022613)2.80095893
106glyoxylate metabolic process (GO:0046487)2.79836255
107pentose-phosphate shunt (GO:0006098)2.78429022
108planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78265481
109negative regulation of histone methylation (GO:0031061)2.77944911
110histone H3-K36 demethylation (GO:0070544)2.76601510
111serine family amino acid catabolic process (GO:0009071)2.73958377
112folic acid-containing compound metabolic process (GO:0006760)2.73895079
113erythrocyte maturation (GO:0043249)2.73416626
114regulation of translational initiation (GO:0006446)2.72086063
115ATP-dependent chromatin remodeling (GO:0043044)2.70628732
116pore complex assembly (GO:0046931)2.70202645
117amino-acid betaine metabolic process (GO:0006577)2.69826096
118pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.69536816
119translation (GO:0006412)2.69397893
120negative regulation of fibrinolysis (GO:0051918)2.68849715
121regulation of histone H3-K9 methylation (GO:0051570)2.68280163
122serine family amino acid biosynthetic process (GO:0009070)2.67358843
123regulation of translational fidelity (GO:0006450)2.66598684
124one-carbon metabolic process (GO:0006730)2.66563195
125regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66399706
126protein localization to kinetochore (GO:0034501)2.65400991
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64138974
128mRNA catabolic process (GO:0006402)2.63548204
129carnitine metabolic process (GO:0009437)2.62921254
130RNA catabolic process (GO:0006401)2.62875720
131regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62578367
132chromosome condensation (GO:0030261)2.61982874
133paraxial mesoderm development (GO:0048339)2.61232085
134proline biosynthetic process (GO:0006561)2.60774076
135oxidative phosphorylation (GO:0006119)2.58975523
136L-phenylalanine catabolic process (GO:0006559)2.58618118
137erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.58618118
138negative regulation of mRNA metabolic process (GO:1903312)2.58599383
139DNA conformation change (GO:0071103)2.57740248
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.57637438
141peptidyl-glutamic acid carboxylation (GO:0017187)2.57251709
142protein carboxylation (GO:0018214)2.57251709
143negative regulation of DNA repair (GO:0045738)2.55907081
144deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55651325
145regulation of sister chromatid cohesion (GO:0007063)2.55096559
146positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54908371
147regulation of chromatin binding (GO:0035561)2.53131336
148epithelial cell differentiation involved in prostate gland development (GO:0060742)2.52637431
149primary alcohol catabolic process (GO:0034310)2.52366556
150IMP biosynthetic process (GO:0006188)2.51976699
151DNA ligation (GO:0006266)2.51539100
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.51284692
153protein localization to chromosome (GO:0034502)2.51267744
154aromatic amino acid family catabolic process (GO:0009074)2.49872823
155protein targeting to membrane (GO:0006612)2.49646190
156peptidyl-arginine N-methylation (GO:0035246)2.49421163
157peptidyl-arginine methylation (GO:0018216)2.49421163
158ribosome assembly (GO:0042255)2.49370225
159tryptophan catabolic process (GO:0006569)2.49132735
160indole-containing compound catabolic process (GO:0042436)2.49132735
161indolalkylamine catabolic process (GO:0046218)2.49132735
162protein export from nucleus (GO:0006611)2.48923833
163peptidyl-arginine omega-N-methylation (GO:0035247)2.48485798
164IMP metabolic process (GO:0046040)2.48230379
165pigment biosynthetic process (GO:0046148)2.47557099
166metaphase plate congression (GO:0051310)2.47512477
167bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47275869
168nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.47204465
169positive regulation of epidermal cell differentiation (GO:0045606)2.46926739
170nucleoside salvage (GO:0043174)2.46550304
171regulation of cytokine secretion involved in immune response (GO:0002739)2.45666393
172sulfur amino acid catabolic process (GO:0000098)2.45549134
173nuclear pore organization (GO:0006999)2.45411877
174DNA replication-independent nucleosome assembly (GO:0006336)2.45255987
175DNA replication-independent nucleosome organization (GO:0034724)2.45255987
176regulation of stem cell maintenance (GO:2000036)2.44915448
177rRNA transcription (GO:0009303)2.44497793
178tetrapyrrole metabolic process (GO:0033013)2.43936143
179pyrimidine nucleoside salvage (GO:0043097)2.43856070
180regulation of mRNA stability (GO:0043488)2.43803158
181regulation of translational termination (GO:0006449)2.43390809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51928326
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.21394604
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67997746
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.60448203
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.30089832
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71996065
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66364372
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48022476
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.44508172
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39608315
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27932915
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25735787
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.18446104
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.12199690
15ZNF263_19887448_ChIP-Seq_K562_Human2.02558356
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97681251
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96945664
18GATA1_22025678_ChIP-Seq_K562_Human1.94635255
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90805428
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.86251562
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85561623
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84252135
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84245627
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81545180
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81499598
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.80160424
27XRN2_22483619_ChIP-Seq_HELA_Human1.79134635
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.78535512
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.76830717
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75567803
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.74622174
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73572433
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73397103
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70295776
35MYC_22102868_ChIP-Seq_BL_Human1.66634866
36DCP1A_22483619_ChIP-Seq_HELA_Human1.63582756
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60666303
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.58851339
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58359821
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57935763
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56406107
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.54988512
43AR_21909140_ChIP-Seq_LNCAP_Human1.54168167
44CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53073412
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.49884868
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49884270
47RACK7_27058665_Chip-Seq_MCF-7_Human1.47590789
48CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46333667
49TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44349918
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41705258
51VDR_23849224_ChIP-Seq_CD4+_Human1.41458457
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41389523
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40635276
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39498099
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38472840
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38113224
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.38099928
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.38009230
59CHD1_26751641_Chip-Seq_LNCaP_Human1.37419549
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36678002
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35921839
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34278936
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33923083
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32721761
65CLOCK_20551151_ChIP-Seq_293T_Human1.32236460
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30653278
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30233719
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29624364
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29461055
70TTF2_22483619_ChIP-Seq_HELA_Human1.28573258
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28459675
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25222416
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25202667
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25097606
75FOXP3_21729870_ChIP-Seq_TREG_Human1.22613689
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21816719
77GABP_19822575_ChIP-Seq_HepG2_Human1.21615888
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21223878
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20397512
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.19756148
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19490926
82TCF7_22412390_ChIP-Seq_EML_Mouse1.19429452
83VDR_21846776_ChIP-Seq_THP-1_Human1.17802872
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17235519
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15698017
86PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15172480
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.14802500
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14265245
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12809835
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11230063
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10710735
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10293222
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10213097
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10182837
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09733100
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09733100
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09733100
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08413137
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.07545449
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07101357
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05400693
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05193393
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04456320
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03379727
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03066826
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02246863
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01781502
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01466855
109KDM5A_27292631_Chip-Seq_BREAST_Human1.01344499
110SOX17_20123909_ChIP-Seq_XEN_Mouse1.00902749
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00146028
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99329753
113CIITA_25753668_ChIP-Seq_RAJI_Human0.99261158
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99255803
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.98584768
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98010160
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96441410
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96260762
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96007711
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95720204
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95294605
122TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95207609
123ATF3_27146783_Chip-Seq_COLON_Human0.94508969
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93299728
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93021513
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92648755
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91159339
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89448174
129TFEB_21752829_ChIP-Seq_HELA_Human0.87202970
130TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86828298
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84091037
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83549865
133SRF_21415370_ChIP-Seq_HL-1_Mouse0.82734738
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81914272
135ELK1_19687146_ChIP-ChIP_HELA_Human0.81608919
136FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81227005
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81103944
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80318149
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79721552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.88792575
2MP0003656_abnormal_erythrocyte_physiolo3.80767050
3MP0002139_abnormal_hepatobiliary_system3.66367222
4MP0003693_abnormal_embryo_hatching3.24263423
5MP0005085_abnormal_gallbladder_physiolo3.13207860
6MP0004957_abnormal_blastocyst_morpholog2.99493561
7MP0005360_urolithiasis2.97717955
8MP0004264_abnormal_extraembryonic_tissu2.95682542
9MP0003111_abnormal_nucleus_morphology2.93719773
10MP0002796_impaired_skin_barrier2.83214138
11MP0010352_gastrointestinal_tract_polyps2.58679653
12MP0010094_abnormal_chromosome_stability2.39668825
13MP0005365_abnormal_bile_salt2.32830889
14MP0000537_abnormal_urethra_morphology2.31422067
15MP0008057_abnormal_DNA_replication2.28526670
16MP0005501_abnormal_skin_physiology2.26470923
17MP0003705_abnormal_hypodermis_morpholog2.25856464
18MP0004147_increased_porphyrin_level2.11241054
19MP0003077_abnormal_cell_cycle2.09124933
20MP0005083_abnormal_biliary_tract1.85198525
21MP0000579_abnormal_nail_morphology1.78862242
22MP0003941_abnormal_skin_development1.75391627
23MP0010030_abnormal_orbit_morphology1.70261615
24MP0008875_abnormal_xenobiotic_pharmacok1.65082226
25MP0000566_synostosis1.59739149
26MP0003186_abnormal_redox_activity1.59414743
27MP0009840_abnormal_foam_cell1.58131244
28MP0009703_decreased_birth_body1.56781698
29MP0003252_abnormal_bile_duct1.54227304
30MP0003566_abnormal_cell_adhesion1.54003338
31MP0010678_abnormal_skin_adnexa1.53395300
32MP0001849_ear_inflammation1.51437446
33MP0010234_abnormal_vibrissa_follicle1.48006010
34MP0005451_abnormal_body_composition1.47728190
35MP0000490_abnormal_crypts_of1.47391124
36MP0002837_dystrophic_cardiac_calcinosis1.45282228
37MP0008260_abnormal_autophagy1.41965730
38MP0006036_abnormal_mitochondrial_physio1.40632779
39MP0006054_spinal_hemorrhage1.39076634
40MP0005076_abnormal_cell_differentiation1.38692680
41MP0003890_abnormal_embryonic-extraembry1.37026934
42MP0002877_abnormal_melanocyte_morpholog1.35239026
43MP0004185_abnormal_adipocyte_glucose1.35121060
44MP0003878_abnormal_ear_physiology1.34839864
45MP0005377_hearing/vestibular/ear_phenot1.34839864
46MP0001545_abnormal_hematopoietic_system1.34546836
47MP0005397_hematopoietic_system_phenotyp1.34546836
48MP0001730_embryonic_growth_arrest1.33918527
49MP0003943_abnormal_hepatobiliary_system1.32896608
50MP0000350_abnormal_cell_proliferation1.32150979
51MP0003453_abnormal_keratinocyte_physiol1.30965680
52MP0003191_abnormal_cellular_cholesterol1.29359575
53MP0009379_abnormal_foot_pigmentation1.29211209
54MP0000609_abnormal_liver_physiology1.29126929
55MP0004233_abnormal_muscle_weight1.27745727
56MP0002009_preneoplasia1.27693143
57MP0003646_muscle_fatigue1.26402787
58MP0002396_abnormal_hematopoietic_system1.25751735
59MP0003315_abnormal_perineum_morphology1.24914582
60MP0010329_abnormal_lipoprotein_level1.24663176
61MP0008932_abnormal_embryonic_tissue1.23654796
62MP0005409_darkened_coat_color1.21969549
63MP0003567_abnormal_fetal_cardiomyocyte1.21161328
64MP0001216_abnormal_epidermal_layer1.20473290
65MP0005319_abnormal_enzyme/_coenzyme1.19362124
66MP0000383_abnormal_hair_follicle1.18581395
67MP0001666_abnormal_nutrient_absorption1.16098952
68MP0004197_abnormal_fetal_growth/weight/1.14372907
69MP0002089_abnormal_postnatal_growth/wei1.12805941
70MP0002060_abnormal_skin_morphology1.12583327
71MP0008877_abnormal_DNA_methylation1.12325976
72MP0003122_maternal_imprinting1.11537557
73MP0005330_cardiomyopathy1.11090664
74MP0001188_hyperpigmentation1.10322880
75MP0009931_abnormal_skin_appearance1.09761179
76MP0002138_abnormal_hepatobiliary_system1.08031231
77MP0000627_abnormal_mammary_gland1.06238320
78MP0004808_abnormal_hematopoietic_stem1.05468238
79MP0009053_abnormal_anal_canal1.05126652
80MP0004782_abnormal_surfactant_physiolog1.04948035
81MP0003221_abnormal_cardiomyocyte_apopto1.04903148
82MP0002019_abnormal_tumor_incidence1.03459468
83MP0005332_abnormal_amino_acid1.02595637
84MP0008058_abnormal_DNA_repair1.02358540
85MP0002086_abnormal_extraembryonic_tissu1.02035973
86MP0001697_abnormal_embryo_size1.01533153
87MP0002080_prenatal_lethality1.00714018
88MP0008007_abnormal_cellular_replicative0.99127663
89MP0002697_abnormal_eye_size0.98856561
90MP0001346_abnormal_lacrimal_gland0.98720024
91MP0003115_abnormal_respiratory_system0.98465359
92MP0003942_abnormal_urinary_system0.97078519
93MP0002132_abnormal_respiratory_system0.95987118
94MP0000462_abnormal_digestive_system0.94988097
95MP0003436_decreased_susceptibility_to0.94887027
96MP0004947_skin_inflammation0.94782787
97MP0003718_maternal_effect0.93593898
98MP0001672_abnormal_embryogenesis/_devel0.93556115
99MP0005380_embryogenesis_phenotype0.93556115
100MP0010307_abnormal_tumor_latency0.93315701
101MP0003937_abnormal_limbs/digits/tail_de0.93052967
102MP0002098_abnormal_vibrissa_morphology0.90412490
103MP0006035_abnormal_mitochondrial_morpho0.90160023
104MP0002111_abnormal_tail_morphology0.90141266
105MP0000678_abnormal_parathyroid_gland0.89755841
106MP0005384_cellular_phenotype0.88584139
107MP0005621_abnormal_cell_physiology0.86582927
108MP0000762_abnormal_tongue_morphology0.84407324
109MP0010771_integument_phenotype0.83844302
110MP0000598_abnormal_liver_morphology0.83747821
111MP0000467_abnormal_esophagus_morphology0.83600711
112MP0005647_abnormal_sex_gland0.83419515
113MP0003121_genomic_imprinting0.83235711
114MP0005666_abnormal_adipose_tissue0.83019306
115MP0005266_abnormal_metabolism0.82239278
116MP0005636_abnormal_mineral_homeostasis0.81229216
117MP0004381_abnormal_hair_follicle0.80899919
118MP0002254_reproductive_system_inflammat0.80640369
119MP0003786_premature_aging0.80096039
120MP0001881_abnormal_mammary_gland0.79057879
121MP0001853_heart_inflammation0.79007747
122MP0004215_abnormal_myocardial_fiber0.78834359
123MP0003984_embryonic_growth_retardation0.78808999
124MP0005275_abnormal_skin_tensile0.78777368
125MP0002088_abnormal_embryonic_growth/wei0.78599659
126MP0004019_abnormal_vitamin_homeostasis0.78362018
127MP0002085_abnormal_embryonic_tissue0.78140676
128MP0005023_abnormal_wound_healing0.76823550
129MP0001764_abnormal_homeostasis0.76184082
130MP0009697_abnormal_copulation0.75545905
131MP0000358_abnormal_cell_content/0.75152243
132MP0000313_abnormal_cell_death0.75017381
133MP0002084_abnormal_developmental_patter0.74041849
134MP0003123_paternal_imprinting0.73610866
135MP0008775_abnormal_heart_ventricle0.73265160
136MP0003195_calcinosis0.73132351
137MP0009643_abnormal_urine_homeostasis0.72765097
138MP0000377_abnormal_hair_follicle0.72034976
139MP0002092_abnormal_eye_morphology0.71604192
140MP0001286_abnormal_eye_development0.71511887
141MP0002118_abnormal_lipid_homeostasis0.71166062
142MP0009763_increased_sensitivity_to0.70939521
143MP0002210_abnormal_sex_determination0.70789329
144MP0009672_abnormal_birth_weight0.70673361
145MP0003119_abnormal_digestive_system0.69481200
146MP0010630_abnormal_cardiac_muscle0.69195426

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.60195754
2Poikilocytosis (HP:0004447)5.27664556
3Abnormality of cells of the erythroid lineage (HP:0012130)4.39474746
4Reticulocytosis (HP:0001923)4.22823950
5Abnormal number of erythroid precursors (HP:0012131)4.17380624
6Abnormality of reticulocytes (HP:0004312)4.15660368
7Reticulocytopenia (HP:0001896)4.02925110
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90812141
9Acanthocytosis (HP:0001927)3.85160372
10Hypochromic microcytic anemia (HP:0004840)3.80933262
11Intrahepatic cholestasis (HP:0001406)3.74190563
12Abnormality of pyrimidine metabolism (HP:0004353)3.46482997
13Asymmetry of the thorax (HP:0001555)3.45527868
14Hypobetalipoproteinemia (HP:0003563)3.42243198
15Hyperbilirubinemia (HP:0002904)3.39122385
16Nephroblastoma (Wilms tumor) (HP:0002667)3.36446607
17Micronodular cirrhosis (HP:0001413)3.28979334
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28875818
19Macrocytic anemia (HP:0001972)3.25065575
20Microglossia (HP:0000171)3.24205614
21Deep venous thrombosis (HP:0002625)3.10132138
22Embryonal renal neoplasm (HP:0011794)3.09099308
23Pallor (HP:0000980)3.06756202
24Chromsome breakage (HP:0040012)3.04469118
25Hypochromic anemia (HP:0001931)2.93009655
26Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90378021
27Xanthomatosis (HP:0000991)2.87230054
28Cholelithiasis (HP:0001081)2.82980091
29Hyperammonemia (HP:0001987)2.74010961
30Oral leukoplakia (HP:0002745)2.73180841
31Curly hair (HP:0002212)2.70647132
32Birth length less than 3rd percentile (HP:0003561)2.68516150
33Hypoglycemic coma (HP:0001325)2.67238520
34Pili torti (HP:0003777)2.66321895
35Uterine leiomyosarcoma (HP:0002891)2.63729161
36Leiomyosarcoma (HP:0100243)2.63729161
37Malignant gastrointestinal tract tumors (HP:0006749)2.63632474
38Gastrointestinal carcinoma (HP:0002672)2.63632474
39Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.62983930
40Septate vagina (HP:0001153)2.62088380
41Nausea (HP:0002018)2.60400657
42Abnormal gallbladder morphology (HP:0012437)2.55431361
43Hypolipoproteinemia (HP:0010981)2.53143471
44Increased nuchal translucency (HP:0010880)2.51948200
45Diaphragmatic weakness (HP:0009113)2.51694170
46Progressive external ophthalmoplegia (HP:0000590)2.50198413
47Prolonged partial thromboplastin time (HP:0003645)2.48318051
48Ankyloglossia (HP:0010296)2.47687555
49Abnormality of the salivary glands (HP:0010286)2.45937611
50Abnormality of iron homeostasis (HP:0011031)2.44846829
51Multiple enchondromatosis (HP:0005701)2.44713186
52Abnormality of methionine metabolism (HP:0010901)2.44319384
53Germ cell neoplasia (HP:0100728)2.43753058
54Woolly hair (HP:0002224)2.42455077
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.42385877
56Back pain (HP:0003418)2.41126916
57Abnormality of nail color (HP:0100643)2.36251650
58Deviation of the thumb (HP:0009603)2.36141464
59Increased serum ferritin (HP:0003281)2.34620094
60Transitional cell carcinoma of the bladder (HP:0006740)2.34211476
61Abnormal hemoglobin (HP:0011902)2.31729389
62Breast carcinoma (HP:0003002)2.31581222
63Ependymoma (HP:0002888)2.31101866
64Enlarged penis (HP:0000040)2.30631580
65Shoulder girdle muscle weakness (HP:0003547)2.29976355
66Microcytic anemia (HP:0001935)2.28958308
67Abnormality of transition element cation homeostasis (HP:0011030)2.27481683
68Termporal pattern (HP:0011008)2.26174624
69Insidious onset (HP:0003587)2.26174624
70Cerebral edema (HP:0002181)2.24505548
71Cortical dysplasia (HP:0002539)2.23966952
72Epidermoid cyst (HP:0200040)2.23218150
73Ketosis (HP:0001946)2.20451712
74Hyperacusis (HP:0010780)2.20187108
75Hepatocellular carcinoma (HP:0001402)2.19656757
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18796373
77Spastic diplegia (HP:0001264)2.16792557
78Proximal placement of thumb (HP:0009623)2.16489145
79Right ventricular cardiomyopathy (HP:0011663)2.15590514
80Deep philtrum (HP:0002002)2.14659614
81Embryonal neoplasm (HP:0002898)2.13412749
82Ventricular tachycardia (HP:0004756)2.12911145
83Flat acetabular roof (HP:0003180)2.12880376
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12837892
85Bladder neoplasm (HP:0009725)2.12503221
86Bladder carcinoma (HP:0002862)2.12503221
87Polycythemia (HP:0001901)2.09266146
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08377392
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08377392
90Hypoalphalipoproteinemia (HP:0003233)2.07137146
91Paralysis (HP:0003470)2.06405717
92Rhabdomyolysis (HP:0003201)2.05877198
93Hypotrichosis (HP:0001006)2.05541409
94Sparse lateral eyebrow (HP:0005338)2.03514100
95Overlapping toe (HP:0001845)2.02576892
96Progressive hearing impairment (HP:0001730)2.01682548
97Basal cell carcinoma (HP:0002671)2.00789409
98Progressive muscle weakness (HP:0003323)1.99812434
99Abnormality of complement system (HP:0005339)1.99773362
100Absent thumb (HP:0009777)1.99641144
101Sparse eyelashes (HP:0000653)1.99187535
102Uterine neoplasm (HP:0010784)1.98263517
103Pustule (HP:0200039)1.98136984
104Breast hypoplasia (HP:0003187)1.96797397
105Abnormality of oral frenula (HP:0000190)1.95813645
106Abnormality of the common coagulation pathway (HP:0010990)1.95809425
107Joint hemorrhage (HP:0005261)1.94447198
108Cutaneous photosensitivity (HP:0000992)1.93613270
109Hyperglycinuria (HP:0003108)1.93595780
110Delayed CNS myelination (HP:0002188)1.92784438
111Abnormality of the preputium (HP:0100587)1.92132264
112Adenoma sebaceum (HP:0009720)1.91850844
113Angiofibromas (HP:0010615)1.91850844
114Pterygium (HP:0001059)1.91261727
115Abnormality of nucleobase metabolism (HP:0010932)1.91131072
116Abnormality of the lacrimal duct (HP:0011481)1.90298710
117Atresia of the external auditory canal (HP:0000413)1.90090611
118Choanal stenosis (HP:0000452)1.88620092
119Congenital ichthyosiform erythroderma (HP:0007431)1.87964620
120Renal cell carcinoma (HP:0005584)1.87534725
121Ragged-red muscle fibers (HP:0003200)1.87386879
122Abnormal lung lobation (HP:0002101)1.85751355
123Macroorchidism (HP:0000053)1.84296067
124Abnormality of the Achilles tendon (HP:0005109)1.83258660
125Myoglobinuria (HP:0002913)1.82986291
126Advanced eruption of teeth (HP:0006288)1.82896648
127Complement deficiency (HP:0004431)1.82709910
128Selective tooth agenesis (HP:0001592)1.82598135
129Choanal atresia (HP:0000453)1.82590150
130Long palpebral fissure (HP:0000637)1.81993609
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.81615463
132Metabolic acidosis (HP:0001942)1.80603858
133Abnormality of fatty-acid metabolism (HP:0004359)1.80575110
134Spinal cord lesions (HP:0100561)1.79932022
135Syringomyelia (HP:0003396)1.79932022
136Dicarboxylic aciduria (HP:0003215)1.79927935
137Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79927935
138Carpal bone hypoplasia (HP:0001498)1.78676622
139Abnormality of the gastric mucosa (HP:0004295)1.77835054
140Abnormal cartilage morphology (HP:0002763)1.77573130
141Colon cancer (HP:0003003)1.75953817
142Partial duplication of thumb phalanx (HP:0009944)1.75767616
143Ketoacidosis (HP:0001993)1.75756441
144Increased muscle lipid content (HP:0009058)1.75387143
145Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.75378265
146Abnormality of glycine metabolism (HP:0010895)1.75300883
147Abnormality of serine family amino acid metabolism (HP:0010894)1.75300883
148Abnormality of serum amino acid levels (HP:0003112)1.75245745
149Urticaria (HP:0001025)1.74824465
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74396229
151Ileus (HP:0002595)1.74213353
152Abnormal blistering of the skin (HP:0008066)1.74213041
153Hyperlipoproteinemia (HP:0010980)1.73651125
154Lethargy (HP:0001254)1.73321110
155Acute lymphatic leukemia (HP:0006721)1.72246538
156Distal lower limb muscle weakness (HP:0009053)1.72110037
157Esophageal varix (HP:0002040)1.71512646
158Abnormality of the gallbladder (HP:0005264)1.71023867
159Hyperglycinemia (HP:0002154)1.69610089
160Cafe-au-lait spot (HP:0000957)1.69592695
161Trismus (HP:0000211)1.68980179
162Abnormality of lateral ventricle (HP:0030047)1.68575019
163Absent eyelashes (HP:0000561)1.68540339
164Nasolacrimal duct obstruction (HP:0000579)1.67587107
165Papillary thyroid carcinoma (HP:0002895)1.63414149
166Duplication of thumb phalanx (HP:0009942)1.62330677
167Anal stenosis (HP:0002025)1.61111899
168Missing ribs (HP:0000921)1.60753172
169Aplasia/Hypoplasia of the sacrum (HP:0008517)1.60666370
170Generalized hypotonia (HP:0001290)1.59463425
171High anterior hairline (HP:0009890)1.56500962
172Arnold-Chiari malformation (HP:0002308)1.55941044
173Abnormality of the nasolacrimal system (HP:0000614)1.53265261
174Volvulus (HP:0002580)1.53142087
175Subacute progressive viral hepatitis (HP:0006572)1.51154355
176Medulloblastoma (HP:0002885)1.50614567
177Horseshoe kidney (HP:0000085)1.50471068
178Abnormality of permanent molar morphology (HP:0011071)1.49034655
179Abnormality of the dental root (HP:0006486)1.49034655
180Taurodontia (HP:0000679)1.49034655
181Thin bony cortex (HP:0002753)1.48323162
182Neoplasm of the pancreas (HP:0002894)1.48208328
183Pelvic girdle muscle weakness (HP:0003749)1.47262375
184Abdominal distention (HP:0003270)1.46543519
185Hyperparathyroidism (HP:0000843)1.45260592
186Rhabdomyosarcoma (HP:0002859)1.45110355
187Broad face (HP:0000283)1.44601266
188Overriding aorta (HP:0002623)1.44358473
189Testicular neoplasm (HP:0010788)1.44179521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.72456406
2SMG13.69812121
3NME23.27082175
4BCKDK3.05884141
5TLK12.92669888
6CDC72.77679568
7BUB12.66266958
8WEE12.58417377
9CDK122.41807479
10DYRK32.35718366
11PKN22.31383221
12MAP3K102.21812428
13RPS6KB22.03861145
14TTK1.89655170
15MAP3K91.84747686
16CDK41.81067892
17NEK11.79298776
18TSSK61.77670870
19STK101.77067066
20MAP3K31.76052004
21TRIB31.75091530
22CDK61.70954064
23BRD41.57669640
24TAF11.56980629
25MAPKAPK31.54156498
26NEK21.53229331
27PASK1.52201962
28FLT31.51715271
29STK41.51445837
30ERN11.50365420
31MAP3K111.49650360
32FGFR41.49232080
33VRK21.48525105
34AURKB1.46356874
35CDK71.44591597
36LRRK21.42175027
37MAP2K31.37129299
38MAP3K81.31553996
39EEF2K1.28076821
40PLK11.27220750
41PAK41.24163983
42BRSK21.23327680
43PIM21.21751377
44BLK1.20505671
45AURKA1.17110234
46IRAK31.15064983
47PIM11.11167214
48MST41.09399467
49RPS6KA41.08323476
50DYRK1B1.04876223
51PBK1.02672622
52TYK21.02065973
53GRK61.01810048
54ATR0.99807566
55TTN0.99233634
56PNCK0.97948110
57EPHA20.96191123
58MAPK110.95631421
59STK160.93967415
60FGFR10.92234484
61SRPK10.89133344
62MST1R0.89043421
63RIPK10.87703123
64PLK30.86514370
65TAOK10.85305348
66PRPF4B0.85157723
67MET0.83678111
68CHEK20.82780145
69MAP2K20.82706432
70FGFR30.82567242
71MUSK0.82122664
72CHEK10.80407697
73NLK0.80175489
74STK240.77764341
75BRSK10.77358934
76RET0.76871568
77ABL20.73748004
78YES10.72851911
79PTK20.72783247
80SGK30.72297446
81EIF2AK20.71327199
82ICK0.70114090
83CLK10.69744645
84CSK0.68462030
85MAP3K20.68044750
86HIPK20.65457824
87SCYL20.63180835
88MAP3K50.62255259
89ATM0.61835739
90RPS6KA50.61610602
91TESK20.61565453
92BMX0.61195866
93CSNK1D0.60305754
94CAMK1G0.59757899
95CDK20.58987381
96RPS6KB10.58330479
97CSNK2A20.58247914
98MKNK10.57065127
99FGFR20.56922414
100PDGFRA0.56613949
101KSR20.56071768
102VRK10.55765217
103CSNK2A10.55745776
104NEK60.55537297
105AKT20.55103954
106ALK0.55071624
107EIF2AK30.54004710
108RPS6KA10.53992697
109BRAF0.53942278
110JAK20.53941333
111STK38L0.53825434
112MELK0.53047497
113FGR0.52973806
114STK30.52580197
115KDR0.52076063
116NEK90.51688338
117ILK0.51008193
118LATS20.50785732
119TGFBR10.50537682
120PTK60.46333071
121PRKD30.45930534
122MKNK20.43431685
123LMTK20.42319704
124MTOR0.42057024
125ZAK0.42005560
126SIK30.40982454
127DYRK20.39781162
128NME10.38427076
129RPS6KL10.37707415
130RPS6KC10.37707415
131TBK10.37428360
132TYRO30.36809116
133BTK0.35112587
134AKT10.34759804
135CDK10.33368021
136PRKCI0.33353994
137ZAP700.32995078
138PRKAA10.32065610
139ERBB40.31284033
140SIK10.30974200
141CSNK1E0.30866158
142MAP3K60.30741661
143LATS10.29256699

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.49895705
2Ribosome_Homo sapiens_hsa030103.42063747
3Mismatch repair_Homo sapiens_hsa034302.77928859
4Thyroid cancer_Homo sapiens_hsa052162.75612095
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67922142
6One carbon pool by folate_Homo sapiens_hsa006702.67645967
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.61219239
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.26094378
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06161526
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00458605
11Chronic myeloid leukemia_Homo sapiens_hsa052201.86197813
12Selenocompound metabolism_Homo sapiens_hsa004501.85551338
13Endometrial cancer_Homo sapiens_hsa052131.83803570
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.81010264
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80797165
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.79304922
17Fatty acid degradation_Homo sapiens_hsa000711.76035472
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75190031
19Arginine biosynthesis_Homo sapiens_hsa002201.75097187
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74304056
21Folate biosynthesis_Homo sapiens_hsa007901.73527186
22Spliceosome_Homo sapiens_hsa030401.70546152
23Nucleotide excision repair_Homo sapiens_hsa034201.68762395
24Proteasome_Homo sapiens_hsa030501.62558924
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.59395344
26Non-small cell lung cancer_Homo sapiens_hsa052231.58693982
27Adherens junction_Homo sapiens_hsa045201.55808761
28Tryptophan metabolism_Homo sapiens_hsa003801.55709832
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55563390
30Base excision repair_Homo sapiens_hsa034101.55108665
31RNA transport_Homo sapiens_hsa030131.53447858
32Acute myeloid leukemia_Homo sapiens_hsa052211.53242196
33Homologous recombination_Homo sapiens_hsa034401.49200184
34Phenylalanine metabolism_Homo sapiens_hsa003601.48745132
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48310904
36Pyrimidine metabolism_Homo sapiens_hsa002401.47495393
37Sulfur relay system_Homo sapiens_hsa041221.46115596
38Biosynthesis of amino acids_Homo sapiens_hsa012301.43274567
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43247944
40Pancreatic cancer_Homo sapiens_hsa052121.43085914
41Prostate cancer_Homo sapiens_hsa052151.41666672
42Systemic lupus erythematosus_Homo sapiens_hsa053221.39075972
43Colorectal cancer_Homo sapiens_hsa052101.39041860
44Carbon metabolism_Homo sapiens_hsa012001.38261588
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35717653
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34356194
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33833072
48beta-Alanine metabolism_Homo sapiens_hsa004101.33069678
49Propanoate metabolism_Homo sapiens_hsa006401.31739498
50Nitrogen metabolism_Homo sapiens_hsa009101.30241739
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.26950063
52Steroid biosynthesis_Homo sapiens_hsa001001.26081475
53Complement and coagulation cascades_Homo sapiens_hsa046101.23942608
54Cell cycle_Homo sapiens_hsa041101.23478575
55Caffeine metabolism_Homo sapiens_hsa002321.21853823
56RNA polymerase_Homo sapiens_hsa030201.14817204
57Renal cell carcinoma_Homo sapiens_hsa052111.12938020
58Fatty acid metabolism_Homo sapiens_hsa012121.12697784
59Hippo signaling pathway_Homo sapiens_hsa043901.09876442
60MicroRNAs in cancer_Homo sapiens_hsa052061.09728604
61p53 signaling pathway_Homo sapiens_hsa041151.08991553
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08910093
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05413451
64Chemical carcinogenesis_Homo sapiens_hsa052041.05336923
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01698566
66Peroxisome_Homo sapiens_hsa041461.01474739
67Basal cell carcinoma_Homo sapiens_hsa052171.01225283
68ErbB signaling pathway_Homo sapiens_hsa040121.00835744
69Small cell lung cancer_Homo sapiens_hsa052221.00421837
70mTOR signaling pathway_Homo sapiens_hsa041501.00328044
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99887598
72Pyruvate metabolism_Homo sapiens_hsa006200.98022324
73Tight junction_Homo sapiens_hsa045300.97362048
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96269131
75Tyrosine metabolism_Homo sapiens_hsa003500.95990081
76PPAR signaling pathway_Homo sapiens_hsa033200.95740773
77Histidine metabolism_Homo sapiens_hsa003400.94319650
78Fanconi anemia pathway_Homo sapiens_hsa034600.93446401
79Pentose phosphate pathway_Homo sapiens_hsa000300.93276589
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92434529
81Insulin signaling pathway_Homo sapiens_hsa049100.92083094
82Proteoglycans in cancer_Homo sapiens_hsa052050.91798326
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91757764
84Galactose metabolism_Homo sapiens_hsa000520.91686140
85VEGF signaling pathway_Homo sapiens_hsa043700.91389085
86Glutathione metabolism_Homo sapiens_hsa004800.90978027
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88410685
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85486032
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85410285
90Vibrio cholerae infection_Homo sapiens_hsa051100.85079897
91Lysine degradation_Homo sapiens_hsa003100.84066051
92N-Glycan biosynthesis_Homo sapiens_hsa005100.83848418
93Retinol metabolism_Homo sapiens_hsa008300.83646806
94Wnt signaling pathway_Homo sapiens_hsa043100.83468448
95Vitamin B6 metabolism_Homo sapiens_hsa007500.83143707
96Staphylococcus aureus infection_Homo sapiens_hsa051500.79660772
97Glioma_Homo sapiens_hsa052140.79216698
98Fat digestion and absorption_Homo sapiens_hsa049750.76854199
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75791305
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75461724
101ABC transporters_Homo sapiens_hsa020100.75230798
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74769896
103Prolactin signaling pathway_Homo sapiens_hsa049170.74189459
104Fructose and mannose metabolism_Homo sapiens_hsa000510.73404008
105Shigellosis_Homo sapiens_hsa051310.72882963
106Arginine and proline metabolism_Homo sapiens_hsa003300.72452411
107Parkinsons disease_Homo sapiens_hsa050120.70568830
108Notch signaling pathway_Homo sapiens_hsa043300.70412859
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.70200191
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70045468
111Hepatitis C_Homo sapiens_hsa051600.69305483
112mRNA surveillance pathway_Homo sapiens_hsa030150.67194759
113Melanoma_Homo sapiens_hsa052180.65874210
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64770907
115HIF-1 signaling pathway_Homo sapiens_hsa040660.64664830
116RNA degradation_Homo sapiens_hsa030180.63175824
117Bladder cancer_Homo sapiens_hsa052190.62522813
118Fatty acid biosynthesis_Homo sapiens_hsa000610.62490993
119Oocyte meiosis_Homo sapiens_hsa041140.62437096
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61843383
121Fatty acid elongation_Homo sapiens_hsa000620.60013264
122Starch and sucrose metabolism_Homo sapiens_hsa005000.59223185
123AMPK signaling pathway_Homo sapiens_hsa041520.57120244
124HTLV-I infection_Homo sapiens_hsa051660.56481869
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.56458012
126Choline metabolism in cancer_Homo sapiens_hsa052310.56176596
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.56151042
128Herpes simplex infection_Homo sapiens_hsa051680.55497353
129Non-homologous end-joining_Homo sapiens_hsa034500.54789833
130Hepatitis B_Homo sapiens_hsa051610.54365829
131Butanoate metabolism_Homo sapiens_hsa006500.54288532
132Viral carcinogenesis_Homo sapiens_hsa052030.53041550
133Apoptosis_Homo sapiens_hsa042100.52824181
134Huntingtons disease_Homo sapiens_hsa050160.51995030
135B cell receptor signaling pathway_Homo sapiens_hsa046620.51750677
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.51060933
137Pathways in cancer_Homo sapiens_hsa052000.50621521
138Oxidative phosphorylation_Homo sapiens_hsa001900.50616606
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50540970
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50148625
141Hedgehog signaling pathway_Homo sapiens_hsa043400.49368437
142Metabolic pathways_Homo sapiens_hsa011000.48301774
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.48150584
144Basal transcription factors_Homo sapiens_hsa030220.47467725
145Sulfur metabolism_Homo sapiens_hsa009200.47384222
146TGF-beta signaling pathway_Homo sapiens_hsa043500.47185030
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46264599
148Inositol phosphate metabolism_Homo sapiens_hsa005620.45101282
149Antigen processing and presentation_Homo sapiens_hsa046120.41812702
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39713437
151Estrogen signaling pathway_Homo sapiens_hsa049150.38657967
152Epstein-Barr virus infection_Homo sapiens_hsa051690.32297820
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27120203
154Linoleic acid metabolism_Homo sapiens_hsa005910.26670222
155Bile secretion_Homo sapiens_hsa049760.25621662
156Purine metabolism_Homo sapiens_hsa002300.24438285
157Viral myocarditis_Homo sapiens_hsa054160.22115082
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21982006
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21092568
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21020616

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