GIF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)8.37750439
2epithelial structure maintenance (GO:0010669)8.01675765
3tongue development (GO:0043586)7.48784686
4protein retention in ER lumen (GO:0006621)7.36116060
5pH reduction (GO:0045851)6.96391137
6leukotriene biosynthetic process (GO:0019370)6.88434164
7phosphatidylserine acyl-chain remodeling (GO:0036150)6.77394379
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.75314187
9arachidonic acid secretion (GO:0050482)6.65689095
10icosanoid secretion (GO:0032309)6.65689095
11lung secretory cell differentiation (GO:0061140)6.65550542
12myeloid leukocyte mediated immunity (GO:0002444)6.53694634
13phosphatidylinositol acyl-chain remodeling (GO:0036149)6.31624110
14sulfation (GO:0051923)6.30792599
15digestive system process (GO:0022600)6.10940169
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.07362908
17icosanoid transport (GO:0071715)5.93314240
18fatty acid derivative transport (GO:1901571)5.93314240
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.93074586
20extracellular fibril organization (GO:0043206)5.79651154
21antibacterial humoral response (GO:0019731)5.77466340
22protein autoprocessing (GO:0016540)5.62772759
23peptidyl-proline hydroxylation (GO:0019511)5.51371521
24antimicrobial humoral response (GO:0019730)5.40785580
25innate immune response in mucosa (GO:0002227)5.37127675
26leukotriene metabolic process (GO:0006691)5.35170058
27glutathione derivative metabolic process (GO:1901685)5.19817507
28glutathione derivative biosynthetic process (GO:1901687)5.19817507
29O-glycan processing (GO:0016266)5.19341895
30purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.18548091
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.18548091
32regulation of pH (GO:0006885)5.18229709
33growth hormone secretion (GO:0030252)5.12441385
34phosphatidylserine metabolic process (GO:0006658)5.11278056
35calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.92649089
36regulation of transforming growth factor beta2 production (GO:0032909)4.89815400
37fibril organization (GO:0097435)4.89092575
38phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.79999594
39extracellular matrix assembly (GO:0085029)4.74138750
40positive regulation of growth hormone secretion (GO:0060124)4.70871118
41chondrocyte proliferation (GO:0035988)4.70013079
42valine metabolic process (GO:0006573)4.63638715
43negative regulation of digestive system process (GO:0060457)4.58509567
44acid secretion (GO:0046717)4.53922050
45central nervous system myelination (GO:0022010)4.52432438
46axon ensheathment in central nervous system (GO:0032291)4.52432438
47lung vasculature development (GO:0060426)4.44354539
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.40830532
49ATP hydrolysis coupled proton transport (GO:0015991)4.40830532
50protein hydroxylation (GO:0018126)4.35304276
51keratan sulfate catabolic process (GO:0042340)4.32792188
52mucosal immune response (GO:0002385)4.29583600
53regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.28533785
54branched-chain amino acid catabolic process (GO:0009083)4.25933023
55intestinal cholesterol absorption (GO:0030299)4.24165389
56diacylglycerol metabolic process (GO:0046339)4.20775526
57regulation of cardioblast differentiation (GO:0051890)4.11980094
58organ or tissue specific immune response (GO:0002251)4.07412556
59alditol phosphate metabolic process (GO:0052646)4.06954412
60ventricular cardiac muscle cell action potential (GO:0086005)3.98037977
61negative regulation of interleukin-1 beta production (GO:0032691)3.96382987
62bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95214550
63response to BMP (GO:0071772)3.93483854
64cellular response to BMP stimulus (GO:0071773)3.93483854
65membrane repolarization during action potential (GO:0086011)3.91715938
66organ formation (GO:0048645)3.89000759
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.85918958
68lung epithelial cell differentiation (GO:0060487)3.82661648
69thyroid hormone metabolic process (GO:0042403)3.82261471
70protein O-linked glycosylation (GO:0006493)3.81780792
71sulfate transmembrane transport (GO:1902358)3.81669790
72branched-chain amino acid metabolic process (GO:0009081)3.80912308
73sequestering of extracellular ligand from receptor (GO:0035581)3.80276960
74embryonic foregut morphogenesis (GO:0048617)3.79505903
75outflow tract septum morphogenesis (GO:0003148)3.78642335
76lung cell differentiation (GO:0060479)3.78509621
77intestinal absorption (GO:0050892)3.77954357
78phosphatidylcholine acyl-chain remodeling (GO:0036151)3.75197380
79somite development (GO:0061053)3.74244949
80thyroid hormone generation (GO:0006590)3.72859676
81negative regulation of interleukin-1 production (GO:0032692)3.70885415
82respiratory tube development (GO:0030323)3.66701839
83tight junction assembly (GO:0070830)3.65308450
84potassium ion transport (GO:0006813)3.64988237
85cell differentiation involved in metanephros development (GO:0072202)3.63540380
86ATP biosynthetic process (GO:0006754)3.63236589
87ethanol oxidation (GO:0006069)3.55343593
88positive regulation of neurological system process (GO:0031646)3.52118762
89phosphatidic acid metabolic process (GO:0046473)3.50034209
90phosphatidic acid biosynthetic process (GO:0006654)3.50034209
91myelin maintenance (GO:0043217)3.46709472
92smooth muscle tissue development (GO:0048745)3.44691321
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.44504498
94embryonic camera-type eye morphogenesis (GO:0048596)3.38455170
95potassium ion export (GO:0071435)3.37982165
96hydrogen ion transmembrane transport (GO:1902600)3.37419041
97monovalent inorganic cation homeostasis (GO:0055067)3.37026321
98regulation of growth hormone secretion (GO:0060123)3.36063452
99purine nucleoside triphosphate biosynthetic process (GO:0009145)3.32031099
100adult feeding behavior (GO:0008343)3.27021854
101regulation of heart rate by cardiac conduction (GO:0086091)3.24142798
102embryonic digestive tract morphogenesis (GO:0048557)3.22318393
103regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.20658024
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.19816517
105glandular epithelial cell differentiation (GO:0002067)3.16980830
106transcytosis (GO:0045056)3.16669195
107basement membrane organization (GO:0071711)3.16449177
108phosphatidylglycerol metabolic process (GO:0046471)3.14021895
109heart morphogenesis (GO:0003007)3.11351089
110lung epithelium development (GO:0060428)3.09049162
111regulation of glucocorticoid secretion (GO:2000849)3.05853850
112regulation of cardiac muscle cell differentiation (GO:2000725)3.05250172
113sulfate transport (GO:0008272)3.04991122
114regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.04722129
115regulation of transforming growth factor beta1 production (GO:0032908)3.03859837
116fucose catabolic process (GO:0019317)3.03792098
117L-fucose metabolic process (GO:0042354)3.03792098
118L-fucose catabolic process (GO:0042355)3.03792098
119positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.03002073
120ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01406772
121endocrine hormone secretion (GO:0060986)2.97829827
122glomerulus development (GO:0032835)2.96818588
123extracellular negative regulation of signal transduction (GO:1900116)2.96046872
124extracellular regulation of signal transduction (GO:1900115)2.96046872
125diaphragm development (GO:0060539)2.95305495
126mesenchymal cell differentiation involved in kidney development (GO:0072161)2.95088814
127mesenchymal cell differentiation involved in renal system development (GO:2001012)2.95088814
128phosphatidylinositol phosphorylation (GO:0046854)2.94755889
129skeletal muscle organ development (GO:0060538)2.93355670
130long-chain fatty acid transport (GO:0015909)2.92655878
131phospholipid scrambling (GO:0017121)2.92526414
132positive regulation of calcium ion transport into cytosol (GO:0010524)2.92430948
133purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.86492684
134purine nucleoside monophosphate biosynthetic process (GO:0009127)2.86492684
135potassium ion import (GO:0010107)2.85949619
136fatty acid derivative biosynthetic process (GO:1901570)2.85224852
137icosanoid biosynthetic process (GO:0046456)2.85224852
138proton transport (GO:0015992)2.84869741
139regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.83866817
140sodium ion export (GO:0071436)2.83055142
141membrane repolarization (GO:0086009)2.82837994
142intestinal epithelial cell development (GO:0060576)2.82087189
143hydrogen transport (GO:0006818)2.81212063
144sulfur amino acid catabolic process (GO:0000098)2.80681845
145endocardial cushion development (GO:0003197)2.78948909
146response to iron ion (GO:0010039)2.78934206
147cardiac conduction (GO:0061337)2.76740714
148cellular response to gonadotropin stimulus (GO:0071371)2.75283819
149xenobiotic metabolic process (GO:0006805)2.73310544
150L-serine transport (GO:0015825)2.73253428
151glycerol metabolic process (GO:0006071)2.70822508
152cell proliferation involved in kidney development (GO:0072111)2.70057505
153collagen fibril organization (GO:0030199)2.69895491
154regulation of metanephros development (GO:0072215)2.69246817
155hematopoietic stem cell proliferation (GO:0071425)2.66842069
156regulation of acrosome reaction (GO:0060046)2.66827390
157positive regulation of vasculogenesis (GO:2001214)2.65764753
158negative regulation of fatty acid transport (GO:2000192)2.64962584
159regulation of membrane repolarization (GO:0060306)2.61951323
160muscle hypertrophy in response to stress (GO:0003299)2.61814334
161cardiac muscle adaptation (GO:0014887)2.61814334
162cardiac muscle hypertrophy in response to stress (GO:0014898)2.61814334
163galactose catabolic process (GO:0019388)2.57458851
164positive regulation of chemokine secretion (GO:0090197)2.55032346
165lung lobe morphogenesis (GO:0060463)2.54988267
166epithelial cell-cell adhesion (GO:0090136)2.53724976
167positive regulation of pseudopodium assembly (GO:0031274)2.53392784
168triglyceride metabolic process (GO:0006641)2.53163928
169smooth muscle cell differentiation (GO:0051145)2.53064936
170regulation of phospholipase A2 activity (GO:0032429)12.4888865
171digestion (GO:0007586)11.5985732
172regulation of proton transport (GO:0010155)10.5636837
173maintenance of gastrointestinal epithelium (GO:0030277)10.4986768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human5.19103562
2SOX2_27498859_Chip-Seq_STOMACH_Mouse5.00115926
3ESR1_15608294_ChIP-ChIP_MCF-7_Human4.13739516
4EGR1_19032775_ChIP-ChIP_M12_Human3.84716455
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.74689420
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65064830
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.41883753
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.06739596
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93958202
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93958202
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93958202
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.90848575
13GATA4_25053715_ChIP-Seq_YYC3_Human2.90181053
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.83662700
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.71061156
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.49975991
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46859418
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.30711990
19GBX2_23144817_ChIP-Seq_PC3_Human2.26643546
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.20433715
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.19456928
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17676444
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.10633278
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08571808
25LXR_22158963_ChIP-Seq_LIVER_Mouse2.01849348
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.99095626
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.98480855
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92774838
29SOX2_20726797_ChIP-Seq_SW620_Human1.88458199
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87516268
31* GATA6_25053715_ChIP-Seq_YYC3_Human1.83330707
32AHR_22903824_ChIP-Seq_MCF-7_Human1.82430042
33KLF5_25053715_ChIP-Seq_YYC3_Human1.77498778
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64086044
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61806479
36CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.56948251
37* LXR_22292898_ChIP-Seq_THP-1_Human1.56511353
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.56171810
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51957192
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51342860
41EZH2_22144423_ChIP-Seq_EOC_Human1.50853928
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.50707010
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50240546
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50068635
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50068635
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49349547
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.47267837
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.45097395
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.44601698
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44370081
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43712580
52CJUN_26792858_Chip-Seq_BT549_Human1.43641228
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.42298827
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41386191
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41255836
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.38531788
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38289895
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.35080099
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34292748
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.34249198
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.32762635
62VDR_22108803_ChIP-Seq_LS180_Human1.31921720
63KDM2B_26808549_Chip-Seq_REH_Human1.31874589
64FUS_26573619_Chip-Seq_HEK293_Human1.31027326
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29394224
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28489161
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28189174
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27751853
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27201928
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26889304
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26488617
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.26482386
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25331561
74STAT1_20625510_ChIP-Seq_HELA_Human1.24879248
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.23638868
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23396349
77BCAT_22108803_ChIP-Seq_LS180_Human1.23132579
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20830660
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18842702
80AR_21572438_ChIP-Seq_LNCaP_Human1.18429261
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.17995888
82RNF2_27304074_Chip-Seq_NSC_Mouse1.17125852
83ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16709704
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.16015498
85RACK7_27058665_Chip-Seq_MCF-7_Human1.15701274
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15508971
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.15246899
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13006828
89ZNF274_21170338_ChIP-Seq_K562_Hela1.12738299
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.12493800
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11381465
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11145579
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11092158
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.10325116
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10040201
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09715022
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.09362641
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08938605
99KDM2B_26808549_Chip-Seq_K562_Human1.08428651
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.08371765
101FOXA1_25552417_ChIP-Seq_VCAP_Human1.06584073
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05447329
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04070427
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03977873
105TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03526426
106SMAD4_21799915_ChIP-Seq_A2780_Human1.03509545
107CLOCK_20551151_ChIP-Seq_293T_Human1.02672496
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.02072571
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01951603
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00510315
111EWS_26573619_Chip-Seq_HEK293_Human1.00378406
112BCOR_27268052_Chip-Seq_Bcells_Human0.99752377
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99594234
114CDX2_22108803_ChIP-Seq_LS180_Human0.99111128
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98868628
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98843783
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.98833589
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.98833589
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97939969
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97640981
121RXR_22108803_ChIP-Seq_LS180_Human0.97489544
122MYC_19829295_ChIP-Seq_ESCs_Human0.96785833
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96397412
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.95539553
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95428446
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95046456
127CREB1_26743006_Chip-Seq_LNCaP_Human0.94773139
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94739649
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94662397
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94357642
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93099307
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.92976689
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92250949
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91802340
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.91189158
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91180627
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90904859
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.90841597
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89046063
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87880708
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85749291
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84945689
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84723632
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84140679
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84140679
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84045794
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83098520
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82941548
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81981958
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81544402
151GATA1_19941826_ChIP-Seq_K562_Human0.80675238
152CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80663856
153GATA1_22025678_ChIP-Seq_K562_Human0.80549997
154DROSHA_22980978_ChIP-Seq_HELA_Human0.79513873
155NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79466257
156NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79466257
157SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79400273
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.79360365
159TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79142161
160P53_21459846_ChIP-Seq_SAOS-2_Human0.78637721
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.77903378
162SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77313822
163ATF3_27146783_Chip-Seq_COLON_Human0.77114992
164PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76422316
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75789029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption5.25668886
2MP0001664_abnormal_digestion4.93434556
3MP0005083_abnormal_biliary_tract4.26157344
4MP0000470_abnormal_stomach_morphology4.13047749
5MP0001873_stomach_inflammation3.41008441
6MP0003868_abnormal_feces_composition3.18666471
7MP0003806_abnormal_nucleotide_metabolis2.83713264
8MP0005275_abnormal_skin_tensile2.78534339
9MP0005085_abnormal_gallbladder_physiolo2.23687705
10MP0005503_abnormal_tendon_morphology2.04511753
11MP0008004_abnormal_stomach_pH16.6797959
12MP0005365_abnormal_bile_salt1.95013646
13MP0005165_increased_susceptibility_to1.52429513
14MP0010234_abnormal_vibrissa_follicle1.50908397
15MP0001663_abnormal_digestive_system1.35953371
16MP0005381_digestive/alimentary_phenotyp1.19456887
17MP0010329_abnormal_lipoprotein_level1.13811232
18MP0004264_abnormal_extraembryonic_tissu1.10627265
19MP0006054_spinal_hemorrhage1.03851095
20MP0001958_emphysema1.02017536
21MP0000566_synostosis0.99113963
22MP0009384_cardiac_valve_regurgitation0.95325409
23MP0004272_abnormal_basement_membrane0.91249672
24MP0008875_abnormal_xenobiotic_pharmacok0.89067112
25MP0002909_abnormal_adrenal_gland0.87463286
26MP0003705_abnormal_hypodermis_morpholog0.87395939
27MP0002139_abnormal_hepatobiliary_system0.86235282
28MP0002118_abnormal_lipid_homeostasis0.83768848
29MP0002108_abnormal_muscle_morphology0.78257666
30MP0005084_abnormal_gallbladder_morpholo0.77834466
31MP0000477_abnormal_intestine_morphology0.76333535
32MP0000534_abnormal_ureter_morphology0.71550552
33MP0003186_abnormal_redox_activity0.71152534
34MP0003953_abnormal_hormone_level0.66791985
35MP0005220_abnormal_exocrine_pancreas0.64280787
36MP0005266_abnormal_metabolism0.63766290
37MP0004185_abnormal_adipocyte_glucose0.63744307
38MP0005670_abnormal_white_adipose0.62242443
39MP0002837_dystrophic_cardiac_calcinosis0.61794559
40MP0004134_abnormal_chest_morphology0.60140340
41MP0003283_abnormal_digestive_organ0.59047227
42MP0000538_abnormal_urinary_bladder0.58142818
43MP0005452_abnormal_adipose_tissue0.55995895
44MP0000467_abnormal_esophagus_morphology0.55629078
45MP0003943_abnormal_hepatobiliary_system0.54308228
46MP0010368_abnormal_lymphatic_system0.54231162
47MP0000462_abnormal_digestive_system0.53594030
48MP0000767_abnormal_smooth_muscle0.53435737
49MP0005508_abnormal_skeleton_morphology0.53156058
50MP0002970_abnormal_white_adipose0.52390472
51MP0002009_preneoplasia0.51601859
52MP0004130_abnormal_muscle_cell0.51144217
53MP0003959_abnormal_lean_body0.49619620
54MP0002078_abnormal_glucose_homeostasis0.49535581
55MP0003075_altered_response_to0.49006532
56MP0000490_abnormal_crypts_of0.48678593
57MP0004484_altered_response_of0.48254495
58MP0001879_abnormal_lymphatic_vessel0.48027406
59MP0005334_abnormal_fat_pad0.47706858
60MP0003252_abnormal_bile_duct0.47561490
61MP0002127_abnormal_cardiovascular_syste0.47475209
62MP0002876_abnormal_thyroid_physiology0.46755850
63MP0003191_abnormal_cellular_cholesterol0.45860697
64MP0002796_impaired_skin_barrier0.44059026
65MP0003942_abnormal_urinary_system0.43896109
66MP0002896_abnormal_bone_mineralization0.43091341
67MP0003119_abnormal_digestive_system0.43013958
68MP0005409_darkened_coat_color0.42802898
69MP0005595_abnormal_vascular_smooth0.42705369
70MP0002693_abnormal_pancreas_physiology0.42264547
71MP0008438_abnormal_cutaneous_collagen0.41931623
72MP0000537_abnormal_urethra_morphology0.41637666
73MP0001243_abnormal_dermal_layer0.41329031
74MP0003115_abnormal_respiratory_system0.39498277
75MP0005448_abnormal_energy_balance0.37262641
76MP0003656_abnormal_erythrocyte_physiolo0.37261567
77MP0000516_abnormal_urinary_system0.37047918
78MP0005367_renal/urinary_system_phenotyp0.37047918
79MP0003329_amyloid_beta_deposits0.36782498
80MP0005319_abnormal_enzyme/_coenzyme0.36626967
81MP0009642_abnormal_blood_homeostasis0.36607904
82MP0004858_abnormal_nervous_system0.35788622
83MP0010155_abnormal_intestine_physiology0.35746780
84MP0001485_abnormal_pinna_reflex0.34690370
85MP0005620_abnormal_muscle_contractility0.34416825
86MP0000598_abnormal_liver_morphology0.32856455
87MP0005166_decreased_susceptibility_to0.32581312
88MP0003941_abnormal_skin_development0.32434961
89MP0005332_abnormal_amino_acid0.32396737
90MP0009379_abnormal_foot_pigmentation0.32289766
91MP0000762_abnormal_tongue_morphology0.32162153
92MP0004859_abnormal_synaptic_plasticity0.32126215
93MP0008961_abnormal_basal_metabolism0.32103598
94MP0009703_decreased_birth_body0.31020444
95MP0009780_abnormal_chondrocyte_physiolo0.30446296
96MP0003279_aneurysm0.30399342
97MP0005360_urolithiasis0.30078889
98MP0003566_abnormal_cell_adhesion0.29887229
99MP0002060_abnormal_skin_morphology0.29406608
100MP0004215_abnormal_myocardial_fiber0.29171339
101MP0000049_abnormal_middle_ear0.29028072
102MP0000230_abnormal_systemic_arterial0.28998734
103MP0000733_abnormal_muscle_development0.28055797
104MP0000751_myopathy0.27886361
105MP0000367_abnormal_coat/_hair0.27863198
106MP0008770_decreased_survivor_rate0.27781831
107MP0004947_skin_inflammation0.27273158
108MP0004043_abnormal_pH_regulation0.26571812
109MP0002069_abnormal_eating/drinking_beha0.26297897
110MP0009643_abnormal_urine_homeostasis0.26231114
111MP0010030_abnormal_orbit_morphology0.25534736
112MP0005375_adipose_tissue_phenotype0.25486598
113MP0003937_abnormal_limbs/digits/tail_de0.25264752
114MP0000609_abnormal_liver_physiology0.24785512
115MP0005310_abnormal_salivary_gland0.24551294
116MP0005584_abnormal_enzyme/coenzyme_acti0.24538803
117MP0001756_abnormal_urination0.24527618
118MP0006276_abnormal_autonomic_nervous0.24431406
119MP0005376_homeostasis/metabolism_phenot0.24355728
120MP0005408_hypopigmentation0.24060557
121MP0009250_abnormal_appendicular_skeleto0.23692513
122MP0006138_congestive_heart_failure0.23388452
123MP0003137_abnormal_impulse_conducting0.23324158
124MP0000428_abnormal_craniofacial_morphol0.23278100
125MP0003935_abnormal_craniofacial_develop0.22573842
126MP0002938_white_spotting0.22328675
127MP0002234_abnormal_pharynx_morphology0.21919162
128MP0005369_muscle_phenotype0.21899359
129MP0002128_abnormal_blood_circulation0.21549783
130MP0002925_abnormal_cardiovascular_devel0.21296952
131MP0000003_abnormal_adipose_tissue0.21126403
132MP0000613_abnormal_salivary_gland0.20904877
133MP0010678_abnormal_skin_adnexa0.20628445
134MP0001614_abnormal_blood_vessel0.20574877
135MP0003690_abnormal_glial_cell0.20537132
136MP0001299_abnormal_eye_distance/0.20472155
137MP0001270_distended_abdomen0.20167678
138MP0000465_gastrointestinal_hemorrhage0.20011700
139MP0001944_abnormal_pancreas_morphology0.19815038
140MP0000266_abnormal_heart_morphology0.19386787
141MP0000163_abnormal_cartilage_morphology0.19198010
142MP0003221_abnormal_cardiomyocyte_apopto0.19062982
143MP0002932_abnormal_joint_morphology0.18921078
144MP0001849_ear_inflammation0.18890565
145MP0003950_abnormal_plasma_membrane0.18441817
146MP0010352_gastrointestinal_tract_polyps0.18440591
147MP0001216_abnormal_epidermal_layer0.18240024
148MP0003183_abnormal_peptide_metabolism0.18198777
149MP0000604_amyloidosis0.18027163
150MP0004808_abnormal_hematopoietic_stem0.17837351
151MP0000013_abnormal_adipose_tissue0.17776337
152MP0002751_abnormal_autonomic_nervous0.17695562
153MP0010630_abnormal_cardiac_muscle0.17488116
154MP0004197_abnormal_fetal_growth/weight/0.17384251
155MP0000432_abnormal_head_morphology0.17232881
156MP0001188_hyperpigmentation0.17066157
157MP0003866_abnormal_defecation0.16681300
158MP0010386_abnormal_urinary_bladder0.16090896
159MP0002877_abnormal_melanocyte_morpholog0.15927559
160MP0001845_abnormal_inflammatory_respons0.15879907
161MP0002972_abnormal_cardiac_muscle0.15087951
162MP0003638_abnormal_response/metabolism_0.14550043
163MP0005666_abnormal_adipose_tissue0.14455683
164MP0001440_abnormal_grooming_behavior0.14124589
165MP0000920_abnormal_myelination0.13869592

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)7.93395096
2Right ventricular cardiomyopathy (HP:0011663)7.13664538
3Ventricular fibrillation (HP:0001663)6.68564051
4Short 4th metacarpal (HP:0010044)5.69093707
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.69093707
6Syncope (HP:0001279)4.93708989
7Tubulointerstitial nephritis (HP:0001970)4.83178555
8Hyperuricemia (HP:0002149)4.44510719
9Increased purine levels (HP:0004368)4.44510719
10Goiter (HP:0000853)4.40949255
11Cerebral aneurysm (HP:0004944)4.31398294
12Abnormality of the aortic arch (HP:0012303)4.27982451
13Abnormality of the 4th metacarpal (HP:0010012)3.92660488
14Tubulointerstitial fibrosis (HP:0005576)3.87808815
15Patent foramen ovale (HP:0001655)3.81023671
16Ketoacidosis (HP:0001993)3.73642732
17Prolonged QT interval (HP:0001657)3.60142790
18Ketosis (HP:0001946)3.54812893
19Malnutrition (HP:0004395)3.49172623
20Abnormality of purine metabolism (HP:0004352)3.47571252
21Lymphangioma (HP:0100764)3.40584553
22Neonatal short-limb short stature (HP:0008921)3.38876692
23Ventricular arrhythmia (HP:0004308)3.37929037
24Renal salt wasting (HP:0000127)3.34496221
25Intrahepatic cholestasis (HP:0001406)3.28309405
26Glomerulosclerosis (HP:0000096)3.24717954
27Congenital sensorineural hearing impairment (HP:0008527)3.14304361
28Aortic dissection (HP:0002647)3.14128013
29Palpitations (HP:0001962)3.13026628
30Aortic aneurysm (HP:0004942)3.04077729
31Double outlet right ventricle (HP:0001719)3.02556340
32Congenital malformation of the right heart (HP:0011723)3.02556340
33Cutaneous finger syndactyly (HP:0010554)2.95684979
34Hyperglycinemia (HP:0002154)2.94180989
35Hyperglycinuria (HP:0003108)2.93444917
36Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.91577815
37Tubular atrophy (HP:0000092)2.91275576
38Abnormality of the fetal cardiovascular system (HP:0010948)2.86681407
39Abnormal umbilical cord blood vessels (HP:0011403)2.86681407
40Single umbilical artery (HP:0001195)2.86681407
41Bladder diverticulum (HP:0000015)2.80576348
42Premature rupture of membranes (HP:0001788)2.76559418
43Abnormality of the distal phalanx of the thumb (HP:0009617)2.71863067
44Neoplasm of the heart (HP:0100544)2.67772048
45Abnormality of the middle phalanges of the toes (HP:0010183)2.67073242
46Broad palm (HP:0001169)2.66609740
47Hyperammonemia (HP:0001987)2.65496564
48Dilatation of the ascending aorta (HP:0005111)2.59403096
49Pulmonary artery stenosis (HP:0004415)2.54963969
50Cupped ribs (HP:0000887)2.53536233
51Woolly hair (HP:0002224)2.51034293
52Abnormality of glycine metabolism (HP:0010895)2.50593620
53Abnormality of serine family amino acid metabolism (HP:0010894)2.50593620
54Arterial tortuosity (HP:0005116)2.48529310
55Pancreatitis (HP:0001733)2.48360337
56Cutaneous syndactyly (HP:0012725)2.47565491
57Wide anterior fontanel (HP:0000260)2.45886914
58Mitral valve prolapse (HP:0001634)2.44525162
59Ankyloglossia (HP:0010296)2.43408059
60Abnormality of the renal cortex (HP:0011035)2.43356159
61Conjugated hyperbilirubinemia (HP:0002908)2.42105144
62Short tibia (HP:0005736)2.40125822
63Cortical dysplasia (HP:0002539)2.38642593
64Frequent falls (HP:0002359)2.37346432
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36496519
66Abnormality of the 2nd finger (HP:0004100)2.35955512
67Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.33966658
68Back pain (HP:0003418)2.33691476
69Deep venous thrombosis (HP:0002625)2.32946210
70Hypoglycemic coma (HP:0001325)2.32778979
71Soft skin (HP:0000977)2.30194062
72Protrusio acetabuli (HP:0003179)2.29599361
73Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.28653575
74Abnormality of abdominal situs (HP:0011620)2.24795464
75Abdominal situs inversus (HP:0003363)2.24795464
76Visceral angiomatosis (HP:0100761)2.24632911
77Abnormality of the proximal phalanges of the hand (HP:0009834)2.24005442
78Cervical subluxation (HP:0003308)2.23549047
79Abnormal tarsal ossification (HP:0008369)2.23526194
80Hyperglycemia (HP:0003074)2.23261906
81Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.22183030
82Sudden cardiac death (HP:0001645)2.22038143
83Abnormal biliary tract morphology (HP:0012440)2.21525678
84Abnormality of fatty-acid metabolism (HP:0004359)2.20398342
85Infantile muscular hypotonia (HP:0008947)2.19715623
86Vascular tortuosity (HP:0004948)2.19632617
87Fat malabsorption (HP:0002630)2.16883006
88Flared iliac wings (HP:0002869)2.16760693
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.15800894
90Relative macrocephaly (HP:0004482)2.15217723
91Abnormality of the phalanges of the hallux (HP:0010057)2.14042882
92Lethargy (HP:0001254)2.13866062
93Abnormality of the epiphyses of the hand (HP:0005924)2.12847088
94Aneurysm (HP:0002617)2.10308838
95Aplasia involving bones of the extremities (HP:0009825)2.10167616
96Aplasia involving bones of the upper limbs (HP:0009823)2.10167616
97Aplasia of the phalanges of the hand (HP:0009802)2.10167616
98Sensorimotor neuropathy (HP:0007141)2.09561426
99Hemangiomatosis (HP:0007461)2.08663623
100Annular pancreas (HP:0001734)2.07851034
101Abnormal pancreas size (HP:0012094)2.06667758
102Abnormality of the ischium (HP:0003174)2.04548858
103Renal hypoplasia (HP:0000089)2.04197953
104Abnormality of oral frenula (HP:0000190)2.03918980
105Abnormality of the dental root (HP:0006486)2.03056061
106Taurodontia (HP:0000679)2.03056061
107Abnormality of permanent molar morphology (HP:0011071)2.03056061
108Peritonitis (HP:0002586)2.02504851
109Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.01757511
110Atrophic scars (HP:0001075)2.01155673
111Abnormal cartilage morphology (HP:0002763)2.00855407
112Abnormality of molar (HP:0011077)1.98150419
113Abnormality of molar morphology (HP:0011070)1.98150419
114Conjunctival hamartoma (HP:0100780)1.97229235
115Abnormality of the gastric mucosa (HP:0004295)1.96898172
116Abnormal EKG (HP:0003115)1.96586094
117Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96509916
118Abnormality of nucleobase metabolism (HP:0010932)1.95549739
119Tubulointerstitial abnormality (HP:0001969)1.94260033
120Abnormal hand bone ossification (HP:0010660)1.93383082
121Hypoalphalipoproteinemia (HP:0003233)1.92946847
122Testicular neoplasm (HP:0010788)1.92539602
123Gastrointestinal dysmotility (HP:0002579)1.92497504
124Germ cell neoplasia (HP:0100728)1.92408742
125Ventricular tachycardia (HP:0004756)1.91725468
126Joint laxity (HP:0001388)1.89703894
127Broad face (HP:0000283)1.89469480
128Striae distensae (HP:0001065)1.88753323
129Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.88057631
130Short clavicles (HP:0000894)1.87776489
131Limited hip movement (HP:0008800)1.87691876
132Turricephaly (HP:0000262)1.87660010
133Midline defect of the nose (HP:0004122)1.87288590
134Abnormal ossification of hand bones (HP:0005921)1.86982348
135Hypotension (HP:0002615)1.85177457
136Wide cranial sutures (HP:0010537)1.85121167
137Facial diplegia (HP:0001349)1.84655341
138Broad forehead (HP:0000337)1.83729960
139Abnormality of the dental pulp (HP:0006479)1.82736150
140Rectal prolapse (HP:0002035)1.82442121
141Hemorrhage of the eye (HP:0011885)1.81587368
142Overgrowth (HP:0001548)1.81469726
143Osteolytic defects of the hand bones (HP:0009699)1.80180503
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.80180503
145Abnormal foot bone ossification (HP:0010675)1.79739524
146Short humerus (HP:0005792)1.79629414
147Pulmonic stenosis (HP:0001642)1.79177339
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78360252
149Long foot (HP:0001833)1.78034940
150Bronchomalacia (HP:0002780)1.77299514
151Aortic regurgitation (HP:0001659)1.76578124
152Spastic diplegia (HP:0001264)1.75463914
153Vascular calcification (HP:0004934)1.75408576
154Short phalanx of the thumb (HP:0009660)1.74685195
155Periodontitis (HP:0000704)1.73278595
156Increased number of teeth (HP:0011069)1.73110743
157Atrial fibrillation (HP:0005110)1.73020214
158Bilateral microphthalmos (HP:0007633)1.71782570
159Aplasia/Hypoplasia of the clavicles (HP:0006710)1.71516919
160Abnormality of incisor morphology (HP:0011063)1.70109313
161Cardiovascular calcification (HP:0011915)1.69938765
162Short middle phalanx of finger (HP:0005819)1.68948727
163Metabolic acidosis (HP:0001942)1.68137836
164Fragile skin (HP:0001030)1.66800587
165Abnormality of the intrinsic pathway (HP:0010989)1.64925541
166Tachypnea (HP:0002789)1.64226090
167Stroke (HP:0001297)1.63694720
168Milia (HP:0001056)1.60053917
169Xanthomatosis (HP:0000991)1.59721451
170Hypoplasia of the pons (HP:0012110)1.59274229
171Primary atrial arrhythmia (HP:0001692)1.58434583
172Esophageal varix (HP:0002040)1.58406326
173Curly hair (HP:0002212)1.58036983
174Vacuolated lymphocytes (HP:0001922)1.57798978
175Increased variability in muscle fiber diameter (HP:0003557)1.55276842
176Growth hormone excess (HP:0000845)1.54693799
177Broad metatarsal (HP:0001783)1.52268405
178Mucopolysacchariduria (HP:0008155)1.52174800
179Urinary glycosaminoglycan excretion (HP:0003541)1.52174800
180Supraventricular tachycardia (HP:0004755)1.51908856
181Cardiomegaly (HP:0001640)1.50766132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.14709002
2MST45.02742452
3MST1R4.82282783
4TRIB33.83346379
5MYLK3.12360891
6PKN22.70483304
7OXSR12.67068774
8LRRK22.59698729
9ERBB42.45108738
10PIK3CG2.41866682
11KSR22.38812233
12MAPK152.33859822
13ZAP702.11484976
14ERN12.10135590
15MET2.02222272
16PDGFRB1.98968242
17RIPK41.93442509
18WNK41.91660761
19FRK1.91168686
20AKT31.88375098
21PDK21.79692513
22MAP3K21.67263733
23STK391.61395885
24NUAK11.56729233
25PTK61.47023635
26LMTK21.46835116
27GRK71.45877748
28STK101.44790572
29MAP3K91.44337533
30PAK31.34692093
31EIF2AK31.27726578
32PIK3CA1.25729939
33MAP2K11.20417112
34FER1.08681153
35ROCK21.08629983
36TTN1.06788112
37MAP2K21.06463868
38TGFBR21.04757615
39DDR21.00977590
40PRKCI0.99172730
41FGFR30.99025826
42PDK30.97447530
43PDK40.97447530
44EEF2K0.95702577
45PAK20.91950781
46TESK10.91881295
47LATS10.91369565
48PDPK10.90599418
49TIE10.89345746
50RET0.87995547
51RPS6KA20.83357731
52EPHB10.82318196
53STK38L0.81032568
54ROCK10.78432529
55BRD40.77760349
56SGK20.75292368
57FGFR40.73907384
58PRKG20.72687503
59NME10.69934860
60PDK10.69782882
61SIK30.69432195
62SIK10.69045336
63PAK60.68636084
64EPHA30.66059262
65CDC42BPA0.64927071
66CAMK1D0.64701733
67MAP3K100.63969167
68WNK10.61752210
69CASK0.61526701
70PTK20.61378668
71NLK0.61229483
72CAMKK20.60719730
73MAP3K60.60683165
74SGK4940.60312926
75SGK2230.60312926
76ERBB20.58535339
77TAOK30.55147810
78MAP2K60.54788041
79FYN0.54304934
80EGFR0.53984240
81NTRK10.53504470
82ICK0.53027309
83SGK30.50694212
84JAK20.49989266
85RIPK10.49658581
86BRSK20.47356095
87MAP2K40.46913003
88MATK0.46135018
89PDGFRA0.45649361
90RPS6KA60.45531910
91CAMKK10.45200322
92MAP3K80.45030298
93DAPK30.44136642
94CDK30.41958797
95NEK10.40435324
96CDK90.40432547
97FGFR10.39949301
98CDK190.39119281
99STK110.37926496
100EPHB20.37839913
101STK30.37105051
102KSR10.37033870
103PRKAA20.36985495
104SRC0.35497511
105PAK40.35356332
106IGF1R0.35320782
107MINK10.34934848
108LIMK10.33906228
109SCYL20.33438829
110PHKG20.33155706
111PHKG10.33155706
112NTRK30.32864482
113RPS6KB20.32752034
114GSK3A0.32392606
115RPS6KC10.31877694
116RPS6KL10.31877694
117DYRK1B0.31875690
118BMX0.31282335
119SMG10.30786566
120INSRR0.30618029
121GRK60.30587592
122MAPKAPK30.30173510
123DMPK0.29463092
124CSK0.29405140
125RPS6KA10.28752009
126MAP3K70.28083725
127ADRBK10.27942109
128CAMK1G0.27816632
129LATS20.27602449
130PTK2B0.27561423
131CLK10.27401229
132ILK0.26626944
133MTOR0.26511629
134MAP3K40.26210587
135PRKD10.26119859
136PRKACB0.25819991
137PRKCE0.24619056
138MAP3K130.24512186
139MAPK10.24392858
140BCR0.24024260
141TYRO30.23990525
142MAPK30.23073484
143EPHA40.23048633
144CAMK10.22954839
145CDK50.21862206
146FGFR20.21359853
147GRK10.19093910
148AKT20.18794383
149MAPK40.18196906
150CAMK40.17533033
151TRPM70.15594205
152AKT10.15402281
153TAF10.15361217
154MARK20.15024328

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049667.43065755
2Fat digestion and absorption_Homo sapiens_hsa049755.34625946
3Gastric acid secretion_Homo sapiens_hsa049715.12039485
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.43833223
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.35612127
6Pancreatic secretion_Homo sapiens_hsa049723.25794040
7Linoleic acid metabolism_Homo sapiens_hsa005913.16815653
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.63998818
9Chemical carcinogenesis_Homo sapiens_hsa052042.35341371
10Sulfur metabolism_Homo sapiens_hsa009202.10110896
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03141139
12Ether lipid metabolism_Homo sapiens_hsa005651.95885096
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.90604819
14Glutathione metabolism_Homo sapiens_hsa004801.81301799
15Glycerolipid metabolism_Homo sapiens_hsa005611.61160023
16Propanoate metabolism_Homo sapiens_hsa006401.60652553
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50184390
18Fatty acid degradation_Homo sapiens_hsa000711.42210311
19Oxidative phosphorylation_Homo sapiens_hsa001901.36889921
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31873990
21Nitrogen metabolism_Homo sapiens_hsa009101.18366246
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17942509
23Arachidonic acid metabolism_Homo sapiens_hsa005901.14556303
24ECM-receptor interaction_Homo sapiens_hsa045121.01253790
25Vascular smooth muscle contraction_Homo sapiens_hsa042700.96752029
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94599465
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94089588
28Focal adhesion_Homo sapiens_hsa045100.89597483
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88890055
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88316894
31Thyroid hormone synthesis_Homo sapiens_hsa049180.87840966
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86994666
33Protein digestion and absorption_Homo sapiens_hsa049740.85514101
34Bile secretion_Homo sapiens_hsa049760.83746245
35Hepatitis C_Homo sapiens_hsa051600.78484000
36Hedgehog signaling pathway_Homo sapiens_hsa043400.78429089
37beta-Alanine metabolism_Homo sapiens_hsa004100.76490874
38Retinol metabolism_Homo sapiens_hsa008300.75703484
39Glycerophospholipid metabolism_Homo sapiens_hsa005640.74954770
40Inositol phosphate metabolism_Homo sapiens_hsa005620.74483787
41Butanoate metabolism_Homo sapiens_hsa006500.70711286
42Histidine metabolism_Homo sapiens_hsa003400.69894147
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68139626
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68029586
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67446240
46Phenylalanine metabolism_Homo sapiens_hsa003600.67346888
47Pyruvate metabolism_Homo sapiens_hsa006200.66279016
48Fatty acid metabolism_Homo sapiens_hsa012120.65382060
49Adherens junction_Homo sapiens_hsa045200.63464453
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.63404077
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60024426
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59986721
53Carbon metabolism_Homo sapiens_hsa012000.58562132
54Chronic myeloid leukemia_Homo sapiens_hsa052200.57763588
55Amoebiasis_Homo sapiens_hsa051460.56466125
56Arginine biosynthesis_Homo sapiens_hsa002200.54936687
57Renal cell carcinoma_Homo sapiens_hsa052110.53330333
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47574295
59Salivary secretion_Homo sapiens_hsa049700.45966225
60Starch and sucrose metabolism_Homo sapiens_hsa005000.45314772
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45247793
62Tryptophan metabolism_Homo sapiens_hsa003800.45134176
63TGF-beta signaling pathway_Homo sapiens_hsa043500.45119319
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45044317
65Basal cell carcinoma_Homo sapiens_hsa052170.44445432
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42212302
67Platelet activation_Homo sapiens_hsa046110.41955536
68Choline metabolism in cancer_Homo sapiens_hsa052310.40165576
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40060353
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39488073
71Tyrosine metabolism_Homo sapiens_hsa003500.38813485
72Notch signaling pathway_Homo sapiens_hsa043300.38785793
73Fatty acid biosynthesis_Homo sapiens_hsa000610.37329475
74Endometrial cancer_Homo sapiens_hsa052130.36991385
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.36093128
76ErbB signaling pathway_Homo sapiens_hsa040120.34968105
77Insulin secretion_Homo sapiens_hsa049110.34521029
78Pathways in cancer_Homo sapiens_hsa052000.34022576
79Prolactin signaling pathway_Homo sapiens_hsa049170.32845943
80Biosynthesis of amino acids_Homo sapiens_hsa012300.32579480
81Gap junction_Homo sapiens_hsa045400.32271674
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32034188
83Circadian rhythm_Homo sapiens_hsa047100.31520863
84Prostate cancer_Homo sapiens_hsa052150.31188581
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30798035
86Mineral absorption_Homo sapiens_hsa049780.30774781
87Dorso-ventral axis formation_Homo sapiens_hsa043200.30739039
88Rap1 signaling pathway_Homo sapiens_hsa040150.30470171
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30464761
90Bladder cancer_Homo sapiens_hsa052190.29807646
91Small cell lung cancer_Homo sapiens_hsa052220.29630638
92Axon guidance_Homo sapiens_hsa043600.29543294
93Colorectal cancer_Homo sapiens_hsa052100.27331450
94PPAR signaling pathway_Homo sapiens_hsa033200.27232259
95Cocaine addiction_Homo sapiens_hsa050300.27177475
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.27079397
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.26859663
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26801422
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26186058
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25785987
101Cholinergic synapse_Homo sapiens_hsa047250.25551511
102Tight junction_Homo sapiens_hsa045300.25534364
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25254941
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24658613
105Insulin signaling pathway_Homo sapiens_hsa049100.24602879
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24580961
107Estrogen signaling pathway_Homo sapiens_hsa049150.24064824
108Lysosome_Homo sapiens_hsa041420.23761608
109Vibrio cholerae infection_Homo sapiens_hsa051100.23516359
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.23240748
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23096308
112Taste transduction_Homo sapiens_hsa047420.22875528
113Hippo signaling pathway_Homo sapiens_hsa043900.22351358
114Calcium signaling pathway_Homo sapiens_hsa040200.19311951
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19184255
116Pancreatic cancer_Homo sapiens_hsa052120.18841413
117Lysine degradation_Homo sapiens_hsa003100.18320039
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17761534
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17619998
120Melanoma_Homo sapiens_hsa052180.17247083
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16924826
122Melanogenesis_Homo sapiens_hsa049160.16363469
123MicroRNAs in cancer_Homo sapiens_hsa052060.15945036
124Peroxisome_Homo sapiens_hsa041460.14495504
125Steroid biosynthesis_Homo sapiens_hsa001000.14334879
126TNF signaling pathway_Homo sapiens_hsa046680.14091832
127Insulin resistance_Homo sapiens_hsa049310.13309363
128MAPK signaling pathway_Homo sapiens_hsa040100.13041623
129Non-small cell lung cancer_Homo sapiens_hsa052230.13041164
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.12107886
131mTOR signaling pathway_Homo sapiens_hsa041500.11963333
132VEGF signaling pathway_Homo sapiens_hsa043700.11755385
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.09975376
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08864824
135Fatty acid elongation_Homo sapiens_hsa000620.08515028
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08391933
137cAMP signaling pathway_Homo sapiens_hsa040240.08133869
138Cardiac muscle contraction_Homo sapiens_hsa042600.07987457
139Long-term potentiation_Homo sapiens_hsa047200.07939229
140GnRH signaling pathway_Homo sapiens_hsa049120.06958181
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.06565757
142Renin secretion_Homo sapiens_hsa049240.06150988
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05186277
144Thyroid cancer_Homo sapiens_hsa052160.04914754
145Other glycan degradation_Homo sapiens_hsa005110.04010417
146Folate biosynthesis_Homo sapiens_hsa007900.03977911
147ABC transporters_Homo sapiens_hsa020100.03909902
148* Vitamin digestion and absorption_Homo sapiens_hsa049770.03716388
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.03586417
150Metabolic pathways_Homo sapiens_hsa011000.03383607
151Ras signaling pathway_Homo sapiens_hsa040140.03300025
152Proteoglycans in cancer_Homo sapiens_hsa052050.03236274
153Fructose and mannose metabolism_Homo sapiens_hsa000510.02144087
154Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02033429
155Glucagon signaling pathway_Homo sapiens_hsa049220.00710131
156Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0024356

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