GIGYF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the gyf family of adaptor proteins. The encoded protein contains a gyf protein interaction domain. It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and insulin receptors and regulates receptor signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)5.43225963
2N-acetylneuraminate metabolic process (GO:0006054)5.26297874
3negative regulation of erythrocyte differentiation (GO:0045647)4.95826070
4negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.95223095
5histone H3-K4 trimethylation (GO:0080182)4.94199812
6protoporphyrinogen IX biosynthetic process (GO:0006782)4.68909746
7mannose metabolic process (GO:0006013)4.48868742
8histone H3-K4 methylation (GO:0051568)4.40629535
9positive regulation of gamma-delta T cell activation (GO:0046645)4.21837491
10negative regulation of phagocytosis (GO:0050765)4.19989677
11positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.17477788
12pre-miRNA processing (GO:0031054)4.11613704
13protoporphyrinogen IX metabolic process (GO:0046501)4.02248600
14amino sugar catabolic process (GO:0046348)4.00839963
15positive regulation of gene expression, epigenetic (GO:0045815)3.92695870
16histone H4-K12 acetylation (GO:0043983)3.92332427
17regulation of gamma-delta T cell differentiation (GO:0045586)3.88198220
18positive thymic T cell selection (GO:0045059)3.85545058
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.83819540
20positive regulation of histone deacetylation (GO:0031065)3.82345769
21negative regulation of interleukin-2 production (GO:0032703)3.75041258
22signal complex assembly (GO:0007172)3.74710624
23regulation of gamma-delta T cell activation (GO:0046643)3.68525204
24negative regulation of translation, ncRNA-mediated (GO:0040033)3.58108211
25regulation of translation, ncRNA-mediated (GO:0045974)3.58108211
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.58108211
27positive T cell selection (GO:0043368)3.54015895
28apoptotic process involved in morphogenesis (GO:0060561)3.52902276
29negative regulation of cell killing (GO:0031342)3.41761785
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41761785
31thymic T cell selection (GO:0045061)3.41674477
32T cell selection (GO:0045058)3.37067013
33histone lysine methylation (GO:0034968)3.34139178
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33405093
35histone H4-K16 acetylation (GO:0043984)3.32330869
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28975398
37mRNA splice site selection (GO:0006376)3.27641373
38histone H4-K8 acetylation (GO:0043982)3.27463910
39histone H4-K5 acetylation (GO:0043981)3.27463910
40microglial cell activation (GO:0001774)3.26398180
41response to muramyl dipeptide (GO:0032495)3.25543688
42negative regulation of cell size (GO:0045792)3.21118251
43regulation of MHC class II biosynthetic process (GO:0045346)3.20400602
44B cell receptor signaling pathway (GO:0050853)3.18858968
45purine deoxyribonucleotide catabolic process (GO:0009155)3.18561095
46antigen processing and presentation of endogenous antigen (GO:0019883)3.18210336
47intracellular estrogen receptor signaling pathway (GO:0030520)3.11258671
48negative regulation of histone methylation (GO:0031061)3.11088394
49peptidyl-lysine trimethylation (GO:0018023)3.09127486
50regulation of protein deacetylation (GO:0090311)3.07940933
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04535612
52positive regulation of CREB transcription factor activity (GO:0032793)2.99659487
53leukocyte aggregation (GO:0070486)2.99382686
54positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.98635206
55megakaryocyte development (GO:0035855)2.97010998
56positive regulation of Rap GTPase activity (GO:0032854)2.96496967
57regulation of histone H3-K4 methylation (GO:0051569)2.96495386
58modulation by symbiont of host cellular process (GO:0044068)2.96399122
59Peyers patch development (GO:0048541)2.95978130
60mucosal-associated lymphoid tissue development (GO:0048537)2.95978130
61negative regulation of mRNA processing (GO:0050686)2.95221471
62positive regulation of RNA splicing (GO:0033120)2.94611325
63negative regulation of histone acetylation (GO:0035067)2.93569700
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91678931
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91440508
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91440508
67positive regulation by organism of defense response of other organism involved in symbiotic interact2.91440508
68modulation by symbiont of host immune response (GO:0052553)2.91440508
69positive regulation by symbiont of host defense response (GO:0052509)2.91440508
70modulation by symbiont of host defense response (GO:0052031)2.91440508
71histone methylation (GO:0016571)2.90160991
72negative thymic T cell selection (GO:0045060)2.88875707
73retinoic acid receptor signaling pathway (GO:0048384)2.87180778
743-UTR-mediated mRNA stabilization (GO:0070935)2.87174758
75negative T cell selection (GO:0043383)2.84838879
76regulation of ARF GTPase activity (GO:0032312)2.84073242
77regulation of protein polyubiquitination (GO:1902914)2.82963534
78poly(A)+ mRNA export from nucleus (GO:0016973)2.82773346
79regulation of protein import into nucleus, translocation (GO:0033158)2.82645786
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81395186
81regulation of fatty acid transport (GO:2000191)2.79331491
82RNA stabilization (GO:0043489)2.79129047
83mRNA stabilization (GO:0048255)2.79129047
84regulation of chromatin binding (GO:0035561)2.78836684
85positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.78546210
86regulation of chemokine biosynthetic process (GO:0045073)2.76974973
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74849237
88histone H3 deacetylation (GO:0070932)2.73933898
89neutrophil mediated immunity (GO:0002446)2.71519709
90negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71100256
91regulation of posttranscriptional gene silencing (GO:0060147)2.69649044
92regulation of gene silencing by miRNA (GO:0060964)2.69649044
93regulation of gene silencing by RNA (GO:0060966)2.69649044
94regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.69457129
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68915326
96regulation of NFAT protein import into nucleus (GO:0051532)2.66856388
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65872567
98positive regulation of protein deacetylation (GO:0090312)2.65665830
99negative regulation of Ras GTPase activity (GO:0034261)2.63466617
100negative regulation of stress fiber assembly (GO:0051497)2.63339276
101negative regulation of actin filament bundle assembly (GO:0032232)2.63153374
102nucleosome disassembly (GO:0006337)2.62284430
103protein-DNA complex disassembly (GO:0032986)2.62284430
104tolerance induction (GO:0002507)2.60119699
105negative regulation of gene expression, epigenetic (GO:0045814)2.59598001
106histone H3-K36 demethylation (GO:0070544)2.58537493
107reactive oxygen species biosynthetic process (GO:1903409)2.58510376
108negative regulation of RNA splicing (GO:0033119)2.58188281
109killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.57782930
110disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.57782930
111regulation of histone H3-K27 methylation (GO:0061085)2.57690391
112histone H3-K9 modification (GO:0061647)2.57307698
113head development (GO:0060322)2.56377845
114negative regulation of peptidyl-lysine acetylation (GO:2000757)2.55938817
115histone deacetylation (GO:0016575)2.54950225
116positive regulation by host of viral transcription (GO:0043923)2.54846036
117positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.54654503
118histone lysine demethylation (GO:0070076)2.52100729
119DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.50927657
120positive regulation of chemokine biosynthetic process (GO:0045080)2.50270992
121regulation of histone deacetylation (GO:0031063)2.50175058
122natural killer cell differentiation (GO:0001779)2.49831812
123positive regulation of protein homooligomerization (GO:0032464)2.49226946
124cytokinetic process (GO:0032506)2.48668727
125positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.47876778
126cellular response to virus (GO:0098586)2.47320456
127regulation of Rap GTPase activity (GO:0032317)2.46272676
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45760437
129histone H4 deacetylation (GO:0070933)2.45522113
130negative regulation of viral release from host cell (GO:1902187)2.45230606
131response to misfolded protein (GO:0051788)2.44893051
132negative regulation of histone modification (GO:0031057)2.44869068
133negative regulation of mRNA metabolic process (GO:1903312)2.44798301
134apoptotic process involved in development (GO:1902742)2.44135738
135chromatin silencing (GO:0006342)2.43784331
136stress granule assembly (GO:0034063)2.42725614
137embryonic placenta development (GO:0001892)2.42650178
138regulation of regulatory T cell differentiation (GO:0045589)2.41591431
139peptidyl-lysine methylation (GO:0018022)2.41424151
140regulation of histone methylation (GO:0031060)2.41269007
141antigen receptor-mediated signaling pathway (GO:0050851)2.41192723
142negative regulation of chromatin modification (GO:1903309)2.41078100
143negative regulation of myotube differentiation (GO:0010832)2.40385259
144regulation of growth of symbiont in host (GO:0044126)2.39836261
145negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.39836261
146activation of JUN kinase activity (GO:0007257)2.39783541
147modulation by virus of host process (GO:0019054)2.39419217
148histone demethylation (GO:0016577)2.39200253
149histone H3-K9 methylation (GO:0051567)2.36375298
150regulation of B cell differentiation (GO:0045577)2.35510315
151cerebellar Purkinje cell differentiation (GO:0021702)2.34720630
152regulation of erythrocyte differentiation (GO:0045646)2.34497040
153protein deacetylation (GO:0006476)2.33804405
154regulation of integrin activation (GO:0033623)2.33383368
155determination of adult lifespan (GO:0008340)2.32568568
156cellular response to zinc ion (GO:0071294)2.32054235
157negative regulation of nucleotide catabolic process (GO:0030812)2.31404725
158cytoplasmic mRNA processing body assembly (GO:0033962)2.30197264
159positive regulation of B cell differentiation (GO:0045579)2.29358262
160cell-substrate adherens junction assembly (GO:0007045)2.28477225
161focal adhesion assembly (GO:0048041)2.28477225
162histone H4 acetylation (GO:0043967)2.26117250
163regulation of B cell receptor signaling pathway (GO:0050855)2.25639102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.69649542
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.15846815
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.13268386
4VDR_21846776_ChIP-Seq_THP-1_Human3.08922377
5KDM2B_26808549_Chip-Seq_SUP-B15_Human3.06825304
6* KDM2B_26808549_Chip-Seq_DND41_Human2.90325141
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88315331
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.83471754
9TCF7_22412390_ChIP-Seq_EML_Mouse2.82113195
10SCL_19346495_ChIP-Seq_HPC-7_Human2.63892280
11* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.56957248
12* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.46671656
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.44492745
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40920392
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40920392
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40920392
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22198875
18KDM2B_26808549_Chip-Seq_JURKAT_Human2.17941933
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.15171932
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08571501
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06096191
22* KDM2B_26808549_Chip-Seq_K562_Human2.02201003
23UTX_26944678_Chip-Seq_JUKART_Human1.98840208
24MAF_26560356_Chip-Seq_TH1_Human1.93900694
25* LXR_22292898_ChIP-Seq_THP-1_Human1.91399783
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91159047
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.85149427
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82551142
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79551007
30CIITA_25753668_ChIP-Seq_RAJI_Human1.77170969
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71658865
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67876313
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66899104
34SPI1_23127762_ChIP-Seq_K562_Human1.61080545
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60966361
36VDR_24763502_ChIP-Seq_THP-1_Human1.59716655
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58996537
38RUNX_20019798_ChIP-Seq_JUKART_Human1.57196274
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.56906711
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56639501
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.53321392
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52989101
43DROSHA_22980978_ChIP-Seq_HELA_Human1.51468738
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51034584
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.50775076
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50618066
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49969382
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49894034
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48861488
50* TET1_21451524_ChIP-Seq_MESCs_Mouse1.45803626
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44949783
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43962586
53MAF_26560356_Chip-Seq_TH2_Human1.43129690
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41917904
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41669489
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41095791
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.39216571
58MYB_26560356_Chip-Seq_TH1_Human1.37599905
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36816279
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36212696
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35162280
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34584062
63NCOR1_26117541_ChIP-Seq_K562_Human1.32075414
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.31507795
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.29127653
66RACK7_27058665_Chip-Seq_MCF-7_Human1.28711435
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28284984
68* BCL6_27268052_Chip-Seq_Bcells_Human1.27643437
69EZH2_22144423_ChIP-Seq_EOC_Human1.26953065
70* BCOR_27268052_Chip-Seq_Bcells_Human1.23693277
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22977303
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22830090
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22668329
74* CREB1_26743006_Chip-Seq_LNCaP_Human1.22017150
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21767065
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21440143
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21307300
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.20528809
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20091459
80* P68_20966046_ChIP-Seq_HELA_Human1.19347851
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19221438
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.18625528
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15638142
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15494841
85* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15076213
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11848012
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.09681133
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09281489
89SA1_27219007_Chip-Seq_Bcells_Human1.08354761
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07865212
91GATA1_19941826_ChIP-Seq_K562_Human1.07566890
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07552298
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06740971
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06592013
95TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06024152
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05358999
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05343960
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05228554
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05004612
100TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04439108
101MYB_26560356_Chip-Seq_TH2_Human1.04335518
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03230209
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02699796
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02160870
105CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01846641
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.01181370
107OCT4_19829295_ChIP-Seq_ESCs_Human1.00550482
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98912684
109RARB_24833708_ChIP-Seq_LIVER_Mouse0.98421411
110RUNX1_27514584_Chip-Seq_MCF-7_Human0.97729211
111JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97639638
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97232774
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97092354
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96778004
115TP63_22573176_ChIP-Seq_HFKS_Human0.96020371
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95706941
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.95363822
118SMC4_20622854_ChIP-Seq_HELA_Human0.94653546
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94639358
120CTCF_27219007_Chip-Seq_Bcells_Human0.93122943
121RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93082356
122E2F1_20622854_ChIP-Seq_HELA_Human0.92759874
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91778979
124PHF8_20622854_ChIP-Seq_HELA_Human0.91293071
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90982159
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.89465362
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88810506
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88620999
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88389666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract5.05464135
2MP0009278_abnormal_bone_marrow3.90709500
3MP0003787_abnormal_imprinting3.15926212
4MP0003436_decreased_susceptibility_to3.11976592
5MP0002653_abnormal_ependyma_morphology2.78017561
6MP0005174_abnormal_tail_pigmentation2.53673297
7MP0008961_abnormal_basal_metabolism2.50012733
8MP0003705_abnormal_hypodermis_morpholog2.47245047
9MP0006292_abnormal_olfactory_placode2.40591705
10MP0003763_abnormal_thymus_physiology2.39668012
11MP0005451_abnormal_body_composition2.32073408
12MP0004510_myositis2.17508012
13MP0000003_abnormal_adipose_tissue2.16120595
14MP0004381_abnormal_hair_follicle2.11167612
15MP0001800_abnormal_humoral_immune2.07242610
16MP0005076_abnormal_cell_differentiation2.02387113
17MP0002254_reproductive_system_inflammat2.02282696
18MP0005387_immune_system_phenotype1.98287320
19MP0001790_abnormal_immune_system1.98287320
20MP0005670_abnormal_white_adipose1.96335117
21MP0004185_abnormal_adipocyte_glucose1.93649781
22MP0000685_abnormal_immune_system1.92227860
23MP0004947_skin_inflammation1.86052563
24MP0005666_abnormal_adipose_tissue1.81273255
25MP0002419_abnormal_innate_immunity1.81205995
26MP0000703_abnormal_thymus_morphology1.77037887
27MP0000569_abnormal_digit_pigmentation1.76368246
28MP0002398_abnormal_bone_marrow1.74461015
29MP0001835_abnormal_antigen_presentation1.71054677
30MP0008995_early_reproductive_senescence1.69405027
31MP0004808_abnormal_hematopoietic_stem1.67515762
32MP0003045_fibrosis1.66213805
33MP0003123_paternal_imprinting1.65355567
34MP0005671_abnormal_response_to1.64696542
35MP0005397_hematopoietic_system_phenotyp1.61153999
36MP0001545_abnormal_hematopoietic_system1.61153999
37MP0008260_abnormal_autophagy1.60333812
38MP0004145_abnormal_muscle_electrophysio1.57923742
39MP0002396_abnormal_hematopoietic_system1.56278149
40MP0003172_abnormal_lysosome_physiology1.56161118
41MP0000015_abnormal_ear_pigmentation1.54542421
42MP0002166_altered_tumor_susceptibility1.53130908
43MP0005075_abnormal_melanosome_morpholog1.52924796
44MP0002009_preneoplasia1.50144600
45MP0000689_abnormal_spleen_morphology1.47180513
46MP0009115_abnormal_fat_cell1.45568678
47MP0005409_darkened_coat_color1.44449777
48MP0003303_peritoneal_inflammation1.40018782
49MP0003283_abnormal_digestive_organ1.38864682
50MP0008569_lethality_at_weaning1.38647872
51MP0002722_abnormal_immune_system1.37917091
52MP0008057_abnormal_DNA_replication1.37118823
53MP0005058_abnormal_lysosome_morphology1.36463200
54MP0000716_abnormal_immune_system1.36308440
55MP0002420_abnormal_adaptive_immunity1.35481228
56MP0002452_abnormal_antigen_presenting1.34811744
57MP0003300_gastrointestinal_ulcer1.33756875
58MP0005365_abnormal_bile_salt1.32081422
59MP0001819_abnormal_immune_cell1.31959540
60MP0002089_abnormal_postnatal_growth/wei1.31578967
61MP0005377_hearing/vestibular/ear_phenot1.31162932
62MP0003878_abnormal_ear_physiology1.31162932
63MP0010630_abnormal_cardiac_muscle1.30519850
64MP0002249_abnormal_larynx_morphology1.28108010
65MP0000678_abnormal_parathyroid_gland1.27309237
66MP0001502_abnormal_circadian_rhythm1.27244416
67MP0002970_abnormal_white_adipose1.26627890
68MP0002723_abnormal_immune_serum1.22115208
69MP0002933_joint_inflammation1.20560928
70MP0000751_myopathy1.20064390
71MP0004859_abnormal_synaptic_plasticity1.19671509
72MP0001533_abnormal_skeleton_physiology1.19372109
73MP0008874_decreased_physiological_sensi1.17555854
74MP0002822_catalepsy1.14430725
75MP0003724_increased_susceptibility_to1.06021526
76MP0002429_abnormal_blood_cell1.05840003
77MP0002998_abnormal_bone_remodeling1.04809341
78MP0002405_respiratory_system_inflammati1.02867701
79MP0009672_abnormal_birth_weight1.02750370
80MP0005464_abnormal_platelet_physiology1.01312137
81MP0003567_abnormal_fetal_cardiomyocyte1.00791225
82MP0000371_diluted_coat_color1.00509682
83MP0005000_abnormal_immune_tolerance0.99742371
84MP0003119_abnormal_digestive_system0.97279046
85MP0005310_abnormal_salivary_gland0.97005668
86MP0003252_abnormal_bile_duct0.95381106
87MP0001853_heart_inflammation0.94302519
88MP0004197_abnormal_fetal_growth/weight/0.93466079
89MP0004043_abnormal_pH_regulation0.93392033
90MP0002075_abnormal_coat/hair_pigmentati0.92996828
91MP0003866_abnormal_defecation0.91292567
92MP0004130_abnormal_muscle_cell0.90870354
93MP0002925_abnormal_cardiovascular_devel0.90291182
94MP0004885_abnormal_endolymph0.90092514
95MP0001784_abnormal_fluid_regulation0.88168080
96MP0009046_muscle_twitch0.87189702
97MP0002106_abnormal_muscle_physiology0.86415300
98MP0002127_abnormal_cardiovascular_syste0.85798559
99MP0010155_abnormal_intestine_physiology0.85787096
100MP0000733_abnormal_muscle_development0.84354948
101MP0009333_abnormal_splenocyte_physiolog0.83810555
102MP0003690_abnormal_glial_cell0.82586289
103MP0003137_abnormal_impulse_conducting0.82291864
104MP0004133_heterotaxia0.82177516
105MP0005025_abnormal_response_to0.80944546
106MP0004858_abnormal_nervous_system0.80938759
107MP0009931_abnormal_skin_appearance0.80460023
108MP0000858_altered_metastatic_potential0.80268724
109MP0004087_abnormal_muscle_fiber0.78097675
110MP0000266_abnormal_heart_morphology0.77054635
111MP0002928_abnormal_bile_duct0.76390151
112MP0003935_abnormal_craniofacial_develop0.76092373
113MP0003121_genomic_imprinting0.75783833
114MP0003453_abnormal_keratinocyte_physiol0.75118909
115MP0003191_abnormal_cellular_cholesterol0.74768800
116MP0003115_abnormal_respiratory_system0.74068903
117MP0008770_decreased_survivor_rate0.73846152
118MP0003828_pulmonary_edema0.73784613
119MP0000470_abnormal_stomach_morphology0.73589233
120MP0001845_abnormal_inflammatory_respons0.72954744
121MP0001730_embryonic_growth_arrest0.71552008
122MP0001348_abnormal_lacrimal_gland0.70912858
123MP0003111_abnormal_nucleus_morphology0.70742780
124MP0002019_abnormal_tumor_incidence0.70521403
125MP0002006_tumorigenesis0.70255308
126MP0003091_abnormal_cell_migration0.70116067
127MP0005375_adipose_tissue_phenotype0.70004165
128MP0010769_abnormal_survival0.69965292
129MP0010768_mortality/aging0.69856978
130MP0005334_abnormal_fat_pad0.69792384
131MP0000428_abnormal_craniofacial_morphol0.69607836
132MP0001849_ear_inflammation0.69592452
133MP0005394_taste/olfaction_phenotype0.68481275
134MP0005499_abnormal_olfactory_system0.68481275
135MP0003861_abnormal_nervous_system0.68126601
136MP0001873_stomach_inflammation0.67297672
137MP0002084_abnormal_developmental_patter0.67110800
138MP0003635_abnormal_synaptic_transmissio0.66446153
139MP0000049_abnormal_middle_ear0.66307159
140MP0005380_embryogenesis_phenotype0.64634751
141MP0001672_abnormal_embryogenesis/_devel0.64634751
142MP0003329_amyloid_beta_deposits0.64181121
143MP0000313_abnormal_cell_death0.61093345
144MP0002971_abnormal_brown_adipose0.60030502
145MP0003566_abnormal_cell_adhesion0.59943280
146MP0008058_abnormal_DNA_repair0.58858568
147MP0010329_abnormal_lipoprotein_level0.56990316

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.33739823
2Eczematoid dermatitis (HP:0000976)3.74515275
3Intestinal fistula (HP:0100819)3.57831895
4Rib fusion (HP:0000902)3.39809071
5Hyperacusis (HP:0010780)3.37431769
6Agammaglobulinemia (HP:0004432)3.15369422
7Supernumerary ribs (HP:0005815)2.99946226
8Panhypogammaglobulinemia (HP:0003139)2.84085435
9Abnormal delayed hypersensitivity skin test (HP:0002963)2.80438304
10Broad face (HP:0000283)2.79274868
11Colitis (HP:0002583)2.78955024
12Obstructive lung disease (HP:0006536)2.78256021
13Chronic obstructive pulmonary disease (HP:0006510)2.78256021
14Depressed nasal tip (HP:0000437)2.77348373
15Supernumerary bones of the axial skeleton (HP:0009144)2.74619596
16Annular pancreas (HP:0001734)2.62613882
17Increased IgE level (HP:0003212)2.60450124
18Dislocated radial head (HP:0003083)2.57715484
19Macroorchidism (HP:0000053)2.54739035
20Turricephaly (HP:0000262)2.48021536
21Prolonged bleeding time (HP:0003010)2.43120077
22Abnormality of the radial head (HP:0003995)2.42380196
23Urethral obstruction (HP:0000796)2.41136740
24Tented upper lip vermilion (HP:0010804)2.39747722
25Polygenic inheritance (HP:0010982)2.39418392
26Elfin facies (HP:0004428)2.39033851
27Disproportionate tall stature (HP:0001519)2.37805494
28Ureteral stenosis (HP:0000071)2.37721865
29Inflammation of the large intestine (HP:0002037)2.37415933
30Stridor (HP:0010307)2.37371343
31Metaphyseal cupping (HP:0003021)2.35594887
32Cellulitis (HP:0100658)2.34401494
33Gastrointestinal inflammation (HP:0004386)2.33182564
34Long eyelashes (HP:0000527)2.32449735
35Recurrent bacterial skin infections (HP:0005406)2.27691866
36Vertebral arch anomaly (HP:0008438)2.27457355
37Myositis (HP:0100614)2.27198264
38Anal stenosis (HP:0002025)2.25592588
39Volvulus (HP:0002580)2.25101092
40Recurrent abscess formation (HP:0002722)2.22613520
41J-shaped sella turcica (HP:0002680)2.22241109
42Cerebral aneurysm (HP:0004944)2.22214907
43Distal lower limb amyotrophy (HP:0008944)2.17922408
44Lip pit (HP:0100267)2.16310195
45Ependymoma (HP:0002888)2.13119706
46Germ cell neoplasia (HP:0100728)2.11340327
47Neonatal hypoglycemia (HP:0001998)2.10304970
48Persistence of primary teeth (HP:0006335)2.10107573
49Generalized hyperpigmentation (HP:0007440)2.09607806
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09465449
51Recurrent fungal infections (HP:0002841)2.09162699
52Dysmetric saccades (HP:0000641)2.08117425
53Ureteral obstruction (HP:0006000)2.08000055
54Recurrent viral infections (HP:0004429)2.06935724
55Abnormal number of incisors (HP:0011064)2.06715139
56Mediastinal lymphadenopathy (HP:0100721)2.05260084
57Acute lymphatic leukemia (HP:0006721)2.04770883
58Neoplasm of the heart (HP:0100544)2.04538940
59Lymphangioma (HP:0100764)2.03215927
60Hemorrhage of the eye (HP:0011885)2.02561968
61Genetic anticipation (HP:0003743)2.01376473
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00545812
63Intestinal atresia (HP:0011100)1.98975418
64Rectovaginal fistula (HP:0000143)1.98232397
65Rectal fistula (HP:0100590)1.98232397
66Pseudobulbar signs (HP:0002200)1.97571111
67Easy fatigability (HP:0003388)1.96940452
68Hemiplegia (HP:0002301)1.96924071
69Abnormality of the columella (HP:0009929)1.96579521
70Viral hepatitis (HP:0006562)1.96408188
71Papilloma (HP:0012740)1.96080759
72Verrucae (HP:0200043)1.96080759
73Astrocytoma (HP:0009592)1.94956138
74Abnormality of the astrocytes (HP:0100707)1.94956138
75Renovascular hypertension (HP:0100817)1.94632128
76Hypochromic anemia (HP:0001931)1.94559209
77Subacute progressive viral hepatitis (HP:0006572)1.94263806
78Renal duplication (HP:0000075)1.93195017
79Diplopia (HP:0000651)1.92656862
80Abnormality of binocular vision (HP:0011514)1.92656862
81Centrally nucleated skeletal muscle fibers (HP:0003687)1.92210931
82Meningitis (HP:0001287)1.91891202
83Abnormality of the left ventricular outflow tract (HP:0011103)1.91654778
84Subaortic stenosis (HP:0001682)1.91654778
85Biconcave vertebral bodies (HP:0004586)1.91310535
86Febrile seizures (HP:0002373)1.91294633
87Abnormality of the lower motor neuron (HP:0002366)1.90533642
88Skull defect (HP:0001362)1.90077757
89Rectal prolapse (HP:0002035)1.89482698
90Pointed chin (HP:0000307)1.89050295
91Basal cell carcinoma (HP:0002671)1.89050032
92Shallow orbits (HP:0000586)1.87935973
93Hamartoma (HP:0010566)1.87858691
94Bronchomalacia (HP:0002780)1.87215444
95Spina bifida occulta (HP:0003298)1.86139020
96Heterotopia (HP:0002282)1.85983398
97Lower limb amyotrophy (HP:0007210)1.85227496
98Narrow nasal bridge (HP:0000446)1.85069878
99Insomnia (HP:0100785)1.82985818
100Obstructive sleep apnea (HP:0002870)1.82474859
101Renal cell carcinoma (HP:0005584)1.82414271
102Reticulocytosis (HP:0001923)1.81721029
103Obsessive-compulsive behavior (HP:0000722)1.79753546
104Recurrent cutaneous fungal infections (HP:0011370)1.79496052
105Chronic mucocutaneous candidiasis (HP:0002728)1.79496052
106Recurrent gram-negative bacterial infections (HP:0005420)1.78766174
107Mask-like facies (HP:0000298)1.78283085
108Increased cerebral lipofuscin (HP:0011813)1.77121071
109Restrictive lung disease (HP:0002091)1.76173715
110Gingivitis (HP:0000230)1.76036214
111High anterior hairline (HP:0009890)1.75992471
112Autoimmune thrombocytopenia (HP:0001973)1.75641366
113T lymphocytopenia (HP:0005403)1.74941197
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.74755408
115Generalized hypotonia (HP:0001290)1.73252975
116Abnormality of the nasal septum (HP:0000419)1.72759760
117Thrombocytosis (HP:0001894)1.72501406
118Nasal polyposis (HP:0100582)1.72394404
119Emphysema (HP:0002097)1.72212303
120Broad distal phalanx of finger (HP:0009836)1.72205012
121Skin tags (HP:0010609)1.71483965
122Ectopic kidney (HP:0000086)1.71292990
123Oligodontia (HP:0000677)1.70976999
124Abnormality of the humeroradial joint (HP:0100744)1.70708215
125Ulnar bowing (HP:0003031)1.70118459
126Slow saccadic eye movements (HP:0000514)1.69243584
127Hypochromic microcytic anemia (HP:0004840)1.68992209
128Sporadic (HP:0003745)1.68606265
129Flat cornea (HP:0007720)1.68341519
130Shawl scrotum (HP:0000049)1.68080860
131Clumsiness (HP:0002312)1.67883113
132Protruding tongue (HP:0010808)1.67773021
133Gastrointestinal infarctions (HP:0005244)1.67677585
134Deep palmar crease (HP:0006191)1.66656328
135Pustule (HP:0200039)1.66643248
136Chest pain (HP:0100749)1.66523593
137Thin bony cortex (HP:0002753)1.66361613
138Broad palm (HP:0001169)1.66081070
139Spinal cord lesions (HP:0100561)1.65798731
140Syringomyelia (HP:0003396)1.65798731
141Granulocytopenia (HP:0001913)1.65685588
142Arterial thrombosis (HP:0004420)1.65142438
143Abnormality of the prostate (HP:0008775)1.65044704
144Vaginal fistula (HP:0004320)1.65002095
145Seborrheic dermatitis (HP:0001051)1.64808125
146Hemoptysis (HP:0002105)1.64762805
147Asymmetry of the thorax (HP:0001555)1.64138086
148Abnormality of the thoracic spine (HP:0100711)1.63870834
149Plagiocephaly (HP:0001357)1.63472089
150Pulmonary infiltrates (HP:0002113)1.62992428
151Segmental peripheral demyelination/remyelination (HP:0003481)1.62126648
152Long palpebral fissure (HP:0000637)1.61941285
153Increased connective tissue (HP:0009025)1.61176832
154Narrow palate (HP:0000189)1.60738316
155Overriding aorta (HP:0002623)1.59918310
156Difficulty running (HP:0009046)1.59885330
157Recurrent skin infections (HP:0001581)1.58846519
158Abnormal vertebral ossification (HP:0100569)1.58393424
159Dysostosis multiplex (HP:0000943)1.57856137
160Neoplasm of the oral cavity (HP:0100649)1.57550285
161Neoplasm of striated muscle (HP:0009728)1.57507975
162Abnormality of chromosome segregation (HP:0002916)1.57441935
163Abnormality of the intervertebral disk (HP:0005108)1.56927637
164Absent frontal sinuses (HP:0002688)1.55744758
165Abnormality of T cell number (HP:0011839)1.55591355
166Dysphonia (HP:0001618)1.54518423
167Supernumerary nipples (HP:0002558)1.54314794
168Abnormality of the nasal mucosa (HP:0000433)1.53405700
169Thyroiditis (HP:0100646)1.52763892
170EMG: neuropathic changes (HP:0003445)1.52750116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.35816087
2CDK124.03033128
3MAP3K103.08309596
4SIK23.01269533
5ICK2.91499140
6NEK22.87975050
7MAP4K12.68950131
8PRPF4B2.38512112
9BRD42.36325398
10CCNB12.35216527
11EEF2K2.20090715
12PRKD21.86948416
13MKNK21.73016181
14CAMKK11.66853315
15TNK21.62825070
16GRK61.58167791
17YES11.48352381
18CAMK1G1.46265020
19UHMK11.42706605
20ALK1.39562686
21TYRO31.36942015
22CAMKK21.36536624
23SGK31.35155407
24MAP2K31.33104992
25TTN1.32060455
26HIPK21.28612045
27MAP3K71.27397847
28TRIB31.25569386
29MAP3K141.23854064
30MARK21.22218484
31CDC42BPA1.21525407
32SIK11.17949646
33PDGFRA1.16849049
34HCK1.16308041
35MAPK151.15379819
36BTK1.13140753
37PTK61.11100117
38CAMK41.10734168
39CSF1R1.09278326
40LRRK21.09190570
41FGFR31.08628040
42CSK1.07445824
43SGK21.07273228
44CAMK1D1.04406812
45TESK21.03604167
46TYK21.03073787
47PRKCH0.99742332
48CDK60.99402101
49IKBKE0.97440302
50NTRK20.96543841
51FES0.94077465
52CHUK0.93747218
53MTOR0.93053957
54FGFR20.92175230
55ERN10.91863701
56JAK10.90239225
57RPS6KL10.89819535
58RPS6KC10.89819535
59PIM10.89345186
60MKNK10.88855628
61MATK0.86649248
62RPS6KA60.86404197
63MAPK70.86185291
64MAP2K20.85425060
65DYRK1B0.84812288
66EPHB10.84656928
67BMX0.84499799
68SIK30.83830535
69WNK10.83519766
70TAF10.81545805
71IKBKB0.80718772
72RIPK10.78440110
73RPS6KB20.77543438
74TBK10.76125663
75LCK0.74689718
76CLK10.74574644
77IRAK30.73635514
78IRAK40.73614227
79RIPK40.72457161
80SYK0.72283766
81CDK40.71661350
82MAPK120.70900303
83PKN20.70730344
84TXK0.70134359
85PHKG20.69955982
86PHKG10.69955982
87STK380.69814628
88VRK20.67238782
89MAP3K130.67012798
90DAPK20.66834069
91FGFR40.65645805
92ZAP700.65411997
93TAOK10.65141356
94TRPM70.63775018
95TGFBR20.62615127
96RPS6KA20.61679438
97CDK70.61620702
98ITK0.60994459
99STK40.59410250
100DAPK10.59226506
101PDGFRB0.58825783
102SGK10.58568708
103AKT30.57783034
104KIT0.57564873
105PDPK10.57132066
106KSR20.56991404
107JAK30.56985250
108MAP3K110.56681514
109FGR0.56438331
110MAP3K10.56431271
111GRK10.54507732
112BLK0.54044756
113MAPK110.53762662
114CAMK10.52964325
115PRKD10.52377046
116JAK20.52242040
117TAOK30.51406847
118STK110.49729853
119MAPK140.48975426
120PASK0.48602979
121RPS6KA10.47971020
122RET0.46613699
123PDK10.45349128
124MAPK40.42680883
125MAP3K60.38987820
126PRKAA20.38113627
127CDK90.37810141
128MELK0.35146585
129MAPK100.33276335
130MAPK80.33051848
131LYN0.31711069
132PRKD30.31344939

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.57807000
2Notch signaling pathway_Homo sapiens_hsa043302.55838026
3Lysine degradation_Homo sapiens_hsa003102.29580178
4Other glycan degradation_Homo sapiens_hsa005112.29015261
5B cell receptor signaling pathway_Homo sapiens_hsa046622.22529967
6Acute myeloid leukemia_Homo sapiens_hsa052211.65408407
7Cyanoamino acid metabolism_Homo sapiens_hsa004601.52744523
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52696154
9Chronic myeloid leukemia_Homo sapiens_hsa052201.49407203
10T cell receptor signaling pathway_Homo sapiens_hsa046601.49221570
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49019597
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44811483
13Thyroid cancer_Homo sapiens_hsa052161.37285630
14Basal cell carcinoma_Homo sapiens_hsa052171.37089511
15mTOR signaling pathway_Homo sapiens_hsa041501.27944693
16Chemokine signaling pathway_Homo sapiens_hsa040621.27082540
17Dorso-ventral axis formation_Homo sapiens_hsa043201.26990913
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24932743
19Type II diabetes mellitus_Homo sapiens_hsa049301.24428711
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23929080
21Non-small cell lung cancer_Homo sapiens_hsa052231.22704132
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21715170
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21570751
24Olfactory transduction_Homo sapiens_hsa047401.21145192
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.20540702
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19777677
27mRNA surveillance pathway_Homo sapiens_hsa030151.19449021
28Osteoclast differentiation_Homo sapiens_hsa043801.17962864
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.17297349
30Renal cell carcinoma_Homo sapiens_hsa052111.17223913
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13324032
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12610665
33Endometrial cancer_Homo sapiens_hsa052131.12357832
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12350817
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11023957
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09602082
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.05921347
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05000498
39Platelet activation_Homo sapiens_hsa046111.03959015
40Hepatitis C_Homo sapiens_hsa051601.03401881
41Measles_Homo sapiens_hsa051621.02426566
42ErbB signaling pathway_Homo sapiens_hsa040121.01631283
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.00826048
44MAPK signaling pathway_Homo sapiens_hsa040100.98865281
45Bladder cancer_Homo sapiens_hsa052190.96829622
46MicroRNAs in cancer_Homo sapiens_hsa052060.96772849
47Glutamatergic synapse_Homo sapiens_hsa047240.96645142
48Hepatitis B_Homo sapiens_hsa051610.96518404
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95039150
50Morphine addiction_Homo sapiens_hsa050320.94642423
51Renin-angiotensin system_Homo sapiens_hsa046140.92082934
52Inositol phosphate metabolism_Homo sapiens_hsa005620.91826333
53Choline metabolism in cancer_Homo sapiens_hsa052310.91690184
54Gastric acid secretion_Homo sapiens_hsa049710.91185241
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.91144092
56GnRH signaling pathway_Homo sapiens_hsa049120.91017858
57Circadian entrainment_Homo sapiens_hsa047130.90678240
58Estrogen signaling pathway_Homo sapiens_hsa049150.90296846
59Wnt signaling pathway_Homo sapiens_hsa043100.89458607
60Glioma_Homo sapiens_hsa052140.89439739
61Staphylococcus aureus infection_Homo sapiens_hsa051500.89400183
62AMPK signaling pathway_Homo sapiens_hsa041520.88887725
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88517411
64Taste transduction_Homo sapiens_hsa047420.88334097
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.87496409
66Prolactin signaling pathway_Homo sapiens_hsa049170.86397922
67Dilated cardiomyopathy_Homo sapiens_hsa054140.86347089
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86229127
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.85234020
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85213483
71Long-term potentiation_Homo sapiens_hsa047200.85162798
72Viral carcinogenesis_Homo sapiens_hsa052030.84821947
73Hedgehog signaling pathway_Homo sapiens_hsa043400.84740831
74Insulin resistance_Homo sapiens_hsa049310.84552511
75Herpes simplex infection_Homo sapiens_hsa051680.84426015
76Rap1 signaling pathway_Homo sapiens_hsa040150.84371052
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83952290
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82386894
79Melanogenesis_Homo sapiens_hsa049160.81978020
80Salivary secretion_Homo sapiens_hsa049700.81889855
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81291673
82Oxytocin signaling pathway_Homo sapiens_hsa049210.80833785
83Long-term depression_Homo sapiens_hsa047300.80434302
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80299050
85Calcium signaling pathway_Homo sapiens_hsa040200.80160023
86Hematopoietic cell lineage_Homo sapiens_hsa046400.80005405
87Tuberculosis_Homo sapiens_hsa051520.78261004
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.78208925
89Pathways in cancer_Homo sapiens_hsa052000.77536735
90Insulin signaling pathway_Homo sapiens_hsa049100.75594085
91FoxO signaling pathway_Homo sapiens_hsa040680.75537041
92Toxoplasmosis_Homo sapiens_hsa051450.75096429
93Colorectal cancer_Homo sapiens_hsa052100.74785137
94VEGF signaling pathway_Homo sapiens_hsa043700.74397370
95Proteoglycans in cancer_Homo sapiens_hsa052050.74170884
96Prostate cancer_Homo sapiens_hsa052150.73670287
97HIF-1 signaling pathway_Homo sapiens_hsa040660.71598741
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71576411
99Small cell lung cancer_Homo sapiens_hsa052220.70933694
100HTLV-I infection_Homo sapiens_hsa051660.70382052
101Leishmaniasis_Homo sapiens_hsa051400.69831559
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69466737
103TNF signaling pathway_Homo sapiens_hsa046680.68093929
104ABC transporters_Homo sapiens_hsa020100.67833410
105Viral myocarditis_Homo sapiens_hsa054160.67599335
106Cholinergic synapse_Homo sapiens_hsa047250.67251705
107Renin secretion_Homo sapiens_hsa049240.66889074
108Apoptosis_Homo sapiens_hsa042100.66194594
109cAMP signaling pathway_Homo sapiens_hsa040240.66028695
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65957321
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65829675
112Epstein-Barr virus infection_Homo sapiens_hsa051690.65277192
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64750609
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64574395
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64522081
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.63121704
117Graft-versus-host disease_Homo sapiens_hsa053320.62651268
118Influenza A_Homo sapiens_hsa051640.61682585
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.60929211
120Base excision repair_Homo sapiens_hsa034100.60381109
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.60336081
122Pancreatic cancer_Homo sapiens_hsa052120.59582568
123Ras signaling pathway_Homo sapiens_hsa040140.59475628
124Focal adhesion_Homo sapiens_hsa045100.59144715
125Insulin secretion_Homo sapiens_hsa049110.58747311
126Spliceosome_Homo sapiens_hsa030400.58525038
127Fatty acid biosynthesis_Homo sapiens_hsa000610.57958433
128Amoebiasis_Homo sapiens_hsa051460.57049319
129Lysosome_Homo sapiens_hsa041420.52124578
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51542721
131Allograft rejection_Homo sapiens_hsa053300.51506225
132Prion diseases_Homo sapiens_hsa050200.51454834
133Fructose and mannose metabolism_Homo sapiens_hsa000510.50776871
134Endocytosis_Homo sapiens_hsa041440.50416985
135Autoimmune thyroid disease_Homo sapiens_hsa053200.50209437

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