GIGYF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.47108385
2sperm motility (GO:0030317)7.97192520
3pattern specification involved in kidney development (GO:0061004)7.67430702
4protein targeting to Golgi (GO:0000042)7.01279690
5establishment of protein localization to Golgi (GO:0072600)6.98443017
6chromosome condensation (GO:0030261)6.79839284
7DNA packaging (GO:0006323)6.68573504
8fusion of sperm to egg plasma membrane (GO:0007342)6.67153694
9sperm capacitation (GO:0048240)5.78554641
10spermatid nucleus differentiation (GO:0007289)5.69402026
11response to pheromone (GO:0019236)5.67924545
12nuclear pore complex assembly (GO:0051292)5.67480966
13spermatid development (GO:0007286)5.63596224
14microtubule depolymerization (GO:0007019)5.56226930
15single strand break repair (GO:0000012)5.42709950
16multicellular organism reproduction (GO:0032504)5.38143504
17sperm-egg recognition (GO:0035036)5.30725500
18pre-miRNA processing (GO:0031054)5.29331178
19mitotic sister chromatid cohesion (GO:0007064)5.25860663
20protein localization to Golgi apparatus (GO:0034067)5.23716541
21nuclear pore organization (GO:0006999)5.22205930
22protein polyglutamylation (GO:0018095)5.15216912
23binding of sperm to zona pellucida (GO:0007339)5.05358729
24plasma membrane fusion (GO:0045026)4.93522243
25centriole replication (GO:0007099)4.85583042
26reproduction (GO:0000003)4.82233584
27microtubule polymerization or depolymerization (GO:0031109)4.75753512
28regulation of RNA export from nucleus (GO:0046831)4.64673187
29phosphatidylethanolamine biosynthetic process (GO:0006646)4.61704037
30negative regulation of inclusion body assembly (GO:0090084)4.59986535
31microtubule severing (GO:0051013)4.57083103
32calcium ion-dependent exocytosis (GO:0017156)4.48321632
33positive regulation of Rab GTPase activity (GO:0032851)4.41138306
34regulation of Rab GTPase activity (GO:0032313)4.41138306
35spermatogenesis (GO:0007283)4.37678960
36male gamete generation (GO:0048232)4.37427120
37cell-cell recognition (GO:0009988)4.35925923
38phosphatidylethanolamine metabolic process (GO:0046337)4.33365628
39rRNA methylation (GO:0031167)4.33228567
40nucleus organization (GO:0006997)4.28080478
41histone H3-K36 demethylation (GO:0070544)4.20356773
42sexual reproduction (GO:0019953)4.10408967
43gamete generation (GO:0007276)4.06303124
44centriole assembly (GO:0098534)4.04848076
45seminiferous tubule development (GO:0072520)4.03781923
46histone H2A monoubiquitination (GO:0035518)3.98408381
47cilium or flagellum-dependent cell motility (GO:0001539)3.97898084
48segment specification (GO:0007379)3.97478333
49monoubiquitinated protein deubiquitination (GO:0035520)3.89497861
50pore complex assembly (GO:0046931)3.88165069
51negative regulation of histone methylation (GO:0031061)3.87563910
52axonemal dynein complex assembly (GO:0070286)3.86549880
53NLS-bearing protein import into nucleus (GO:0006607)3.85400905
54cytoplasmic mRNA processing body assembly (GO:0033962)3.83912499
55histone lysine demethylation (GO:0070076)3.81272130
56regulation of protein polyubiquitination (GO:1902914)3.79112058
57RNA destabilization (GO:0050779)3.78667720
58regulation of nucleobase-containing compound transport (GO:0032239)3.66487439
59paraxial mesoderm development (GO:0048339)3.64681266
60histone demethylation (GO:0016577)3.62807472
61histone H3-K4 methylation (GO:0051568)3.61602917
62single fertilization (GO:0007338)3.59321041
63cellular ketone body metabolic process (GO:0046950)3.54183438
64histone H3-K4 trimethylation (GO:0080182)3.52938395
65peptidyl-threonine dephosphorylation (GO:0035970)3.52023410
66glucocorticoid receptor signaling pathway (GO:0042921)3.48675358
67histone H3-K9 demethylation (GO:0033169)3.44429604
68Golgi to endosome transport (GO:0006895)3.43882113
69germ cell development (GO:0007281)3.41743615
70regulation of sister chromatid cohesion (GO:0007063)3.35915141
71fertilization (GO:0009566)3.34949323
72histone H3-K9 methylation (GO:0051567)3.32388573
73motile cilium assembly (GO:0044458)3.30692290
74epithelial cilium movement (GO:0003351)3.29845425
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27465921
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27465921
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.27465921
78regulation of inclusion body assembly (GO:0090083)3.26862798
79cellular process involved in reproduction in multicellular organism (GO:0022412)3.26390602
80multicellular organismal reproductive process (GO:0048609)3.26336938
81histone H4-K12 acetylation (GO:0043983)3.26322808
82microtubule nucleation (GO:0007020)3.24382544
83intra-Golgi vesicle-mediated transport (GO:0006891)3.24180853
84peptidyl-lysine trimethylation (GO:0018023)3.23390178
85protein dealkylation (GO:0008214)3.23049692
86protein demethylation (GO:0006482)3.23049692
87regulation of mitotic spindle organization (GO:0060236)3.22424243
88mitotic chromosome condensation (GO:0007076)3.22320238
89regulation of DNA endoreduplication (GO:0032875)3.21253347
90glomerular visceral epithelial cell development (GO:0072015)3.19966967
91heterochromatin organization (GO:0070828)3.19194425
92regulation of histone H3-K9 methylation (GO:0051570)3.18202541
93negative regulation of DNA repair (GO:0045738)3.17770753
94embryonic retina morphogenesis in camera-type eye (GO:0060059)3.16974936
95rRNA modification (GO:0000154)3.16279483
96ketone body metabolic process (GO:1902224)3.15995157
97vesicle transport along microtubule (GO:0047496)3.15094733
98histone lysine methylation (GO:0034968)3.12048754
99regulation of transcription involved in cell fate commitment (GO:0060850)3.11069190
100regulation of translational fidelity (GO:0006450)3.05495826
101corticosteroid receptor signaling pathway (GO:0031958)3.04833077
102regulation of cilium movement (GO:0003352)3.04800219
103hippo signaling (GO:0035329)3.04360532
104histone H3-K9 modification (GO:0061647)3.02894441
105stress granule assembly (GO:0034063)3.01197434
106protein-DNA complex disassembly (GO:0032986)2.99044575
107nucleosome disassembly (GO:0006337)2.99044575
108mitotic nuclear envelope disassembly (GO:0007077)2.97663490
109sister chromatid segregation (GO:0000819)2.95766453
110sister chromatid cohesion (GO:0007062)2.95749415
111negative regulation of Rho protein signal transduction (GO:0035024)2.95597682
112glomerular epithelial cell development (GO:0072310)2.94931946
113regulation of spindle organization (GO:0090224)2.93965252
114cilium movement (GO:0003341)2.92977797
115DNA conformation change (GO:0071103)2.91226639
116protein localization to kinetochore (GO:0034501)2.90944991
117genitalia morphogenesis (GO:0035112)2.89153833
118membrane disassembly (GO:0030397)2.87625558
119nuclear envelope disassembly (GO:0051081)2.87625558
120chromatin assembly (GO:0031497)2.87339544
121RNA localization (GO:0006403)2.86875626
122intestinal epithelial cell development (GO:0060576)2.86572342
123DNA duplex unwinding (GO:0032508)2.85218670
124gene silencing (GO:0016458)2.83663622
125regulation of somitogenesis (GO:0014807)2.83299976
126DNA geometric change (GO:0032392)2.83104873
127RNA stabilization (GO:0043489)2.81667912
128mRNA stabilization (GO:0048255)2.81667912
129protein K48-linked deubiquitination (GO:0071108)2.80803977
130gene silencing by RNA (GO:0031047)2.80524738
131interkinetic nuclear migration (GO:0022027)2.78835926
132histone methylation (GO:0016571)2.78492886
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.77871140
134regulation of translation, ncRNA-mediated (GO:0045974)2.77871140
135negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77871140
136peptidyl-lysine dimethylation (GO:0018027)2.76886020
137positive regulation of SMAD protein import into nucleus (GO:0060391)2.76603901
138regulation of centrosome duplication (GO:0010824)2.76094510
139regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.75438398
140positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.75438398
141histone mRNA catabolic process (GO:0071044)2.72019797
142positive regulation of chromosome segregation (GO:0051984)2.71893929
143negative regulation of histone modification (GO:0031057)2.71606899
144response to UV-C (GO:0010225)2.71388815
145histone H4-K16 acetylation (GO:0043984)2.71368196
146centrosome duplication (GO:0051298)2.69919122
147* insulin-like growth factor receptor signaling pathway (GO:0048009)2.68758269
148regulation of DNA damage checkpoint (GO:2000001)2.68483268
149determination of adult lifespan (GO:0008340)2.68195250
150trophectodermal cell differentiation (GO:0001829)2.68186635
151spliceosomal tri-snRNP complex assembly (GO:0000244)2.67984444
152positive regulation of histone deacetylation (GO:0031065)2.67196220
153regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.66554779
154coronary vasculature morphogenesis (GO:0060977)2.65516741
155negative regulation of gene expression, epigenetic (GO:0045814)2.63056142
156negative regulation of chromatin modification (GO:1903309)2.62955047
157peptidyl-lysine methylation (GO:0018022)2.62656209
158epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62172605
159histone H4-K5 acetylation (GO:0043981)2.61557424
160histone H4-K8 acetylation (GO:0043982)2.61557424
161regulation of histone H3-K27 methylation (GO:0061085)2.61277559
162chromatin silencing (GO:0006342)2.61074250
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.59799071
164embryonic camera-type eye morphogenesis (GO:0048596)2.57523602
165cell wall macromolecule catabolic process (GO:0016998)2.56759329
166regulation of centriole replication (GO:0046599)2.56235659
167DNA methylation involved in gamete generation (GO:0043046)2.54038363
168spindle assembly involved in mitosis (GO:0090307)2.53732363
169mRNA splice site selection (GO:0006376)2.53204559
170macroautophagy (GO:0016236)2.53095625
171histone H2A ubiquitination (GO:0033522)2.52987206
172face development (GO:0060324)2.52688489
173regulation of gene silencing by RNA (GO:0060966)2.52513966
174regulation of posttranscriptional gene silencing (GO:0060147)2.52513966
175regulation of gene silencing by miRNA (GO:0060964)2.52513966
176protein localization to chromosome, centromeric region (GO:0071459)2.51831437
177regulation of hippo signaling (GO:0035330)2.51364281
178mitotic sister chromatid segregation (GO:0000070)2.51185943
179negative regulation of mRNA metabolic process (GO:1903312)2.49977057
180microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.49542553
181retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48956881
182protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.48057975
183cell wall macromolecule metabolic process (GO:0044036)2.47823015
184regulation of establishment of cell polarity (GO:2000114)2.45485963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40324941
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60143765
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.30422570
4* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.77523657
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.50665846
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75667720
7EZH2_22144423_ChIP-Seq_EOC_Human2.68872219
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.61930554
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60874830
10POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.60874830
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59010506
12CBP_20019798_ChIP-Seq_JUKART_Human2.50099247
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.50099247
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49755785
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28473070
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.15738912
17AR_21572438_ChIP-Seq_LNCaP_Human2.12330572
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10962670
19GBX2_23144817_ChIP-Seq_PC3_Human2.08065515
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06200324
21FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human2.05062329
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04797872
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02365998
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99964320
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96393394
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94550437
27DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.87904915
28MYC_22102868_ChIP-Seq_BL_Human1.83890522
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80739064
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77744431
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.77530499
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.74046605
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.70607088
34SMAD4_21799915_ChIP-Seq_A2780_Human1.70596992
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69711712
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67994829
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66924735
38ER_23166858_ChIP-Seq_MCF-7_Human1.65389057
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65363496
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64671826
41TBX3_20139965_ChIP-Seq_ESCs_Mouse1.63846972
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63408089
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61826744
44TBX3_20139965_ChIP-Seq_MESCs_Mouse1.61417577
45P300_19829295_ChIP-Seq_ESCs_Human1.61403521
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57685429
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57196390
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56730920
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56371032
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56195924
51TP53_16413492_ChIP-PET_HCT116_Human1.55721150
52AR_25329375_ChIP-Seq_VCAP_Human1.54028236
53TP53_18474530_ChIP-ChIP_U2OS_Human1.53488572
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53053850
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53051410
56DROSHA_22980978_ChIP-Seq_HELA_Human1.52748986
57TAF15_26573619_Chip-Seq_HEK293_Human1.52264328
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51393164
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.50344704
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49540137
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49109882
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.48736507
63AR_21909140_ChIP-Seq_LNCAP_Human1.48446114
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.44507341
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42833951
66SMAD4_21741376_ChIP-Seq_EPCs_Human1.41489049
67ZNF274_21170338_ChIP-Seq_K562_Hela1.39886236
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38629670
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38629670
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38629670
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.38386271
72RUNX2_22187159_ChIP-Seq_PCA_Human1.38361058
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38149300
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36795533
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35501004
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.35312973
77TCF7_22412390_ChIP-Seq_EML_Mouse1.34580230
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34033157
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.32811686
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32003934
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31415013
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.31204286
83TBL1_22424771_ChIP-Seq_293T_Human1.30136257
84CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29039607
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28946498
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28661129
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27287890
88BRD4_25478319_ChIP-Seq_HGPS_Human1.26512603
89KDM2B_26808549_Chip-Seq_REH_Human1.24132134
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23998132
91GF1_26923725_Chip-Seq_HPCs_Mouse1.23836010
92ETV1_20927104_ChIP-Seq_GIST48_Human1.22842739
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22143309
94NFYB_21822215_ChIP-Seq_K562_Human1.22012843
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21681579
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.21146387
97CHD1_26751641_Chip-Seq_LNCaP_Human1.19803451
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17685120
99POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17676595
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.17649067
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16977341
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16725775
103KDM2B_26808549_Chip-Seq_DND41_Human1.16198643
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16175347
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16092812
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.15993492
107TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15101187
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14984913
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14806841
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14278360
111GATA6_25053715_ChIP-Seq_YYC3_Human1.13864197
112HNFA_21074721_ChIP-Seq_CACO-2_Human1.13571015
113* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11423960
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10924886
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.10049581
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09724658
117AHR_22903824_ChIP-Seq_MCF-7_Human1.09705535
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09328793
119STAT3_23295773_ChIP-Seq_U87_Human1.09171104
120GF1B_26923725_Chip-Seq_HPCs_Mouse1.08347441
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08053460
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.07717527
123RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07652219
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07426491
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07386559
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07074243
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06977011
128SMAD4_21741376_ChIP-Seq_HESCs_Human1.06616453
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06381534
130RBPJ_21746931_ChIP-Seq_IB4_Human1.06019765
131AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05841606
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05686474
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05626194
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05564323
135ARNT_22903824_ChIP-Seq_MCF-7_Human1.04638830
136ESR1_21235772_ChIP-Seq_MCF-7_Human1.04357569
137* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03166022
138CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02379420
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02349151
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01975769
141KDM2B_26808549_Chip-Seq_JURKAT_Human1.01132267
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00950609
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00774552
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00600095
145KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00574935
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00319487
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99960144
148PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99086140
149PHF8_20622853_ChIP-Seq_HELA_Human0.99036185
150* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98780903
151SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98695335
152CIITA_25753668_ChIP-Seq_RAJI_Human0.98620843
153TP63_23658742_ChIP-Seq_EP156T_Human0.98474100
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.98117290
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97931763
156TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97929195
157KDM5A_27292631_Chip-Seq_BREAST_Human0.97659589
158SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97281140
159AR_19668381_ChIP-Seq_PC3_Human0.97159738
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96898052
161* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95120535
162NFYA_21822215_ChIP-Seq_K562_Human0.94986845
163FUS_26573619_Chip-Seq_HEK293_Human0.94864453
164RUNX1_27514584_Chip-Seq_MCF-7_Human0.90339892
165STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89241082
166TCF4_23295773_ChIP-Seq_U87_Human0.88380957
167TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88361193
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.87891691
169PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87847244
170ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85975376
171TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84413936
172NANOG_16518401_ChIP-PET_MESCs_Mouse0.84016221
173ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83624153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.62992188
2MP0003878_abnormal_ear_physiology3.78181765
3MP0005377_hearing/vestibular/ear_phenot3.78181765
4MP0003698_abnormal_male_reproductive3.55305841
5MP0000569_abnormal_digit_pigmentation3.22058899
6MP0001929_abnormal_gametogenesis3.18125194
7MP0005076_abnormal_cell_differentiation2.91965650
8MP0003705_abnormal_hypodermis_morpholog2.88750254
9MP0010352_gastrointestinal_tract_polyps2.79496043
10MP0004264_abnormal_extraembryonic_tissu2.78344838
11MP0003646_muscle_fatigue2.61829389
12MP0010234_abnormal_vibrissa_follicle2.55629268
13MP0003111_abnormal_nucleus_morphology2.55526745
14MP0003787_abnormal_imprinting2.34758120
15MP0010094_abnormal_chromosome_stability2.22141007
16MP0003890_abnormal_embryonic-extraembry2.21019126
17MP0008057_abnormal_DNA_replication2.18414213
18MP0003121_genomic_imprinting2.12215157
19MP0010307_abnormal_tumor_latency2.09739634
20MP0008877_abnormal_DNA_methylation2.06859327
21MP0002084_abnormal_developmental_patter2.05763874
22MP0004197_abnormal_fetal_growth/weight/2.03398397
23MP0002161_abnormal_fertility/fecundity1.99563282
24MP0005380_embryogenesis_phenotype1.91659910
25MP0001672_abnormal_embryogenesis/_devel1.91659910
26MP0004185_abnormal_adipocyte_glucose1.91501021
27MP0003984_embryonic_growth_retardation1.86470011
28MP0002088_abnormal_embryonic_growth/wei1.85555231
29MP0000537_abnormal_urethra_morphology1.83840123
30MP0003123_paternal_imprinting1.81337575
31MP0002877_abnormal_melanocyte_morpholog1.78889076
32MP0002086_abnormal_extraembryonic_tissu1.75639209
33* MP0003077_abnormal_cell_cycle1.75230738
34MP0001348_abnormal_lacrimal_gland1.71466765
35MP0003566_abnormal_cell_adhesion1.70853557
36MP0001730_embryonic_growth_arrest1.70382136
37MP0009703_decreased_birth_body1.70309497
38MP0002085_abnormal_embryonic_tissue1.64416125
39MP0002210_abnormal_sex_determination1.61958090
40MP0000350_abnormal_cell_proliferation1.61710325
41MP0003045_fibrosis1.58278662
42MP0003941_abnormal_skin_development1.57087226
43MP0002009_preneoplasia1.53232362
44MP0003718_maternal_effect1.53049143
45MP0003935_abnormal_craniofacial_develop1.52072452
46MP0000678_abnormal_parathyroid_gland1.51840406
47MP0000733_abnormal_muscle_development1.49719617
48MP0005409_darkened_coat_color1.48040089
49MP0004957_abnormal_blastocyst_morpholog1.46745005
50MP0001697_abnormal_embryo_size1.46545719
51MP0000428_abnormal_craniofacial_morphol1.45264676
52MP0003937_abnormal_limbs/digits/tail_de1.43987990
53MP0005666_abnormal_adipose_tissue1.42010286
54MP0000534_abnormal_ureter_morphology1.41931447
55MP0005310_abnormal_salivary_gland1.41565862
56MP0003693_abnormal_embryo_hatching1.39842371
57MP0010678_abnormal_skin_adnexa1.39040788
58MP0001849_ear_inflammation1.38376036
59MP0008058_abnormal_DNA_repair1.38294708
60MP0000432_abnormal_head_morphology1.35972473
61MP0009115_abnormal_fat_cell1.34538163
62MP0005451_abnormal_body_composition1.34273430
63MP0003119_abnormal_digestive_system1.33785593
64MP0001145_abnormal_male_reproductive1.33446311
65MP0009672_abnormal_birth_weight1.32596989
66MP0003283_abnormal_digestive_organ1.31807675
67MP0001984_abnormal_olfaction1.30588371
68MP0003091_abnormal_cell_migration1.29548783
69MP0001485_abnormal_pinna_reflex1.29299689
70MP0003567_abnormal_fetal_cardiomyocyte1.29068272
71MP0005623_abnormal_meninges_morphology1.28150071
72MP0001486_abnormal_startle_reflex1.27744982
73MP0000653_abnormal_sex_gland1.26877793
74MP0003300_gastrointestinal_ulcer1.26863511
75MP0001915_intracranial_hemorrhage1.25136221
76MP0009780_abnormal_chondrocyte_physiolo1.24325727
77MP0004808_abnormal_hematopoietic_stem1.23285627
78MP0002697_abnormal_eye_size1.19909886
79MP0000778_abnormal_nervous_system1.19518795
80MP0003252_abnormal_bile_duct1.18943487
81MP0000516_abnormal_urinary_system1.18214476
82MP0005367_renal/urinary_system_phenotyp1.18214476
83MP0002080_prenatal_lethality1.18077759
84MP0002925_abnormal_cardiovascular_devel1.17326036
85MP0004233_abnormal_muscle_weight1.15347055
86MP0003115_abnormal_respiratory_system1.11916135
87MP0002396_abnormal_hematopoietic_system1.11675150
88MP0003879_abnormal_hair_cell1.10787356
89MP0001293_anophthalmia1.10500721
90MP0005375_adipose_tissue_phenotype1.08495350
91MP0002138_abnormal_hepatobiliary_system1.07667712
92MP0008961_abnormal_basal_metabolism1.07572186
93MP0000566_synostosis1.06901789
94MP0002127_abnormal_cardiovascular_syste1.06020346
95MP0005395_other_phenotype1.05712871
96MP0003755_abnormal_palate_morphology1.05370079
97MP0000383_abnormal_hair_follicle1.04584547
98MP0005379_endocrine/exocrine_gland_phen1.03259611
99MP0000003_abnormal_adipose_tissue1.02753193
100MP0003868_abnormal_feces_composition1.02352673
101MP0010630_abnormal_cardiac_muscle1.01632703
102MP0008007_abnormal_cellular_replicative1.01369338
103MP0002092_abnormal_eye_morphology1.01284410
104MP0005187_abnormal_penis_morphology1.00245220
105MP0003011_delayed_dark_adaptation0.99202955
106MP0002234_abnormal_pharynx_morphology0.98367695
107MP0005257_abnormal_intraocular_pressure0.98294723
108MP0009384_cardiac_valve_regurgitation0.98004804
109MP0001286_abnormal_eye_development0.96758961
110MP0002928_abnormal_bile_duct0.95071069
111MP0002249_abnormal_larynx_morphology0.94592528
112MP0002557_abnormal_social/conspecific_i0.94278452
113MP0000266_abnormal_heart_morphology0.94268668
114MP0002653_abnormal_ependyma_morphology0.94239731
115MP0001299_abnormal_eye_distance/0.93095150
116MP0005023_abnormal_wound_healing0.89305752
117MP0004036_abnormal_muscle_relaxation0.86718508
118MP0003861_abnormal_nervous_system0.86301239
119* MP0000955_abnormal_spinal_cord0.86198259
120MP0002896_abnormal_bone_mineralization0.85668360
121MP0005220_abnormal_exocrine_pancreas0.85410715
122MP0005621_abnormal_cell_physiology0.84531623
123MP0005670_abnormal_white_adipose0.84100660
124MP0004272_abnormal_basement_membrane0.83904293
125MP0002168_other_aberrant_phenotype0.82574830
126MP0003385_abnormal_body_wall0.81877795
127MP0003122_maternal_imprinting0.81603428
128MP0005551_abnormal_eye_electrophysiolog0.81163725
129MP0002971_abnormal_brown_adipose0.80906793
130MP0003942_abnormal_urinary_system0.80803198
131MP0001784_abnormal_fluid_regulation0.80679148
132MP0002111_abnormal_tail_morphology0.80361775
133MP0008770_decreased_survivor_rate0.79096626
134MP0004742_abnormal_vestibular_system0.78659584
135MP0000026_abnormal_inner_ear0.78491850
136MP0005253_abnormal_eye_physiology0.77696095
137MP0002116_abnormal_craniofacial_bone0.77461776
138MP0009053_abnormal_anal_canal0.77246759
139MP0000462_abnormal_digestive_system0.77020008
140MP0005248_abnormal_Harderian_gland0.76256874
141MP0002269_muscular_atrophy0.76040025
142MP0002108_abnormal_muscle_morphology0.75420801
143MP0004084_abnormal_cardiac_muscle0.73904111
144MP0002067_abnormal_sensory_capabilities0.72962842
145MP0001879_abnormal_lymphatic_vessel0.72952578
146MP0004859_abnormal_synaptic_plasticity0.71468516
147MP0005384_cellular_phenotype0.70901586
148MP0004484_altered_response_of0.70784269
149MP0002282_abnormal_trachea_morphology0.67612184
150MP0003936_abnormal_reproductive_system0.67490059
151MP0000631_abnormal_neuroendocrine_gland0.64994136
152MP0003329_amyloid_beta_deposits0.63719040
153MP0005408_hypopigmentation0.63376168
154MP0001765_abnormal_ion_homeostasis0.63261978
155MP0001963_abnormal_hearing_physiology0.62170484
156MP0003959_abnormal_lean_body0.61781536
157MP0000427_abnormal_hair_cycle0.61492545
158MP0002184_abnormal_innervation0.61484702
159MP0003136_yellow_coat_color0.61348521
160MP0002152_abnormal_brain_morphology0.60363557
161MP0002109_abnormal_limb_morphology0.59003213

Predicted human phenotypes

RankGene SetZ-score
1Hyperkalemia (HP:0002153)4.82369796
2Severe visual impairment (HP:0001141)4.72457992
3Tubulointerstitial nephritis (HP:0001970)4.33568448
4Chronic hepatic failure (HP:0100626)4.13114788
5Volvulus (HP:0002580)3.62737801
6Abnormality of the fingertips (HP:0001211)3.61509058
7Asymmetric septal hypertrophy (HP:0001670)3.22974189
8Bony spicule pigmentary retinopathy (HP:0007737)3.13898214
9Attenuation of retinal blood vessels (HP:0007843)2.99996273
10Bell-shaped thorax (HP:0001591)2.99775086
11Urethral obstruction (HP:0000796)2.99380746
12Nephronophthisis (HP:0000090)2.89078916
13Macroorchidism (HP:0000053)2.88519394
14Abnormality of the astrocytes (HP:0100707)2.88473005
15Astrocytoma (HP:0009592)2.88473005
16Hypoplastic ischia (HP:0003175)2.87079649
17Absent/shortened dynein arms (HP:0200106)2.85247232
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.85247232
19Heterotopia (HP:0002282)2.83612029
20Aplasia/Hypoplasia of the earlobes (HP:0009906)2.82367882
21Ependymoma (HP:0002888)2.82008176
22Cone-rod dystrophy (HP:0000548)2.80250680
23Abnormality of macular pigmentation (HP:0008002)2.79012378
24Congenital malformation of the right heart (HP:0011723)2.78230867
25Double outlet right ventricle (HP:0001719)2.78230867
26Long eyelashes (HP:0000527)2.72975484
27Abnormality of the renal medulla (HP:0100957)2.62398061
28Progressive sensorineural hearing impairment (HP:0000408)2.57635946
29Neoplasm of the oral cavity (HP:0100649)2.57320490
30Abnormality of potassium homeostasis (HP:0011042)2.51645429
31Abnormality of the ischium (HP:0003174)2.49963767
32Menstrual irregularities (HP:0000858)2.49062431
33Abnormality of the labia minora (HP:0012880)2.45344352
34Anal stenosis (HP:0002025)2.44546331
35Prominent nose (HP:0000448)2.42683366
36Shallow orbits (HP:0000586)2.41464984
37Progressive cerebellar ataxia (HP:0002073)2.41019625
38Abnormality of the aortic arch (HP:0012303)2.39139223
39Papillary thyroid carcinoma (HP:0002895)2.38785821
40Infertility (HP:0000789)2.38172272
41Truncal obesity (HP:0001956)2.36412250
42Deviation of the thumb (HP:0009603)2.32113275
43Glioma (HP:0009733)2.31782660
44Narrow palate (HP:0000189)2.30016119
45Increased nuchal translucency (HP:0010880)2.28819912
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28259377
47Tubulointerstitial abnormality (HP:0001969)2.26428632
48Obsessive-compulsive behavior (HP:0000722)2.25833174
49Hypoplasia of the thymus (HP:0000778)2.25073231
50Genetic anticipation (HP:0003743)2.23416815
51Midline defect of the nose (HP:0004122)2.21923996
52Potter facies (HP:0002009)2.20141698
53Facial shape deformation (HP:0011334)2.20141698
54Abnormal respiratory motile cilium physiology (HP:0012261)2.19998787
55Hypoplastic labia majora (HP:0000059)2.19109092
56Stage 5 chronic kidney disease (HP:0003774)2.18011316
57Abnormal ciliary motility (HP:0012262)2.17720820
58Neoplasm of the heart (HP:0100544)2.16699622
59Short 4th metacarpal (HP:0010044)2.16481774
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16481774
61Broad thumb (HP:0011304)2.16008195
62Abnormality of the parathyroid morphology (HP:0011766)2.13575528
63Cerebral aneurysm (HP:0004944)2.13275652
64Absent frontal sinuses (HP:0002688)2.12889226
65Tubular atrophy (HP:0000092)2.12298191
66Biliary tract neoplasm (HP:0100574)2.11667694
67Male infertility (HP:0003251)2.10736846
68Abnormal drinking behavior (HP:0030082)2.07516998
69Polydipsia (HP:0001959)2.07516998
70Proximal placement of thumb (HP:0009623)2.07515226
71Lip pit (HP:0100267)2.05370638
72Medulloblastoma (HP:0002885)2.03756483
73Hypoalphalipoproteinemia (HP:0003233)2.01553218
74Smooth philtrum (HP:0000319)2.01510729
75Gastrointestinal carcinoma (HP:0002672)2.00935093
76Malignant gastrointestinal tract tumors (HP:0006749)2.00935093
77Osteomalacia (HP:0002749)2.00831552
78Supernumerary ribs (HP:0005815)2.00464978
79Abnormality of the labia majora (HP:0012881)1.99114727
80Termporal pattern (HP:0011008)1.98806985
81Insidious onset (HP:0003587)1.98806985
82Portal hypertension (HP:0001409)1.97503327
83Intellectual disability, moderate (HP:0002342)1.95443571
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94265212
85Enlarged epiphyses (HP:0010580)1.93793851
86Abnormal rod and cone electroretinograms (HP:0008323)1.92581147
87Hyperacusis (HP:0010780)1.91892929
88Sparse lateral eyebrow (HP:0005338)1.91131049
89Trigonocephaly (HP:0000243)1.90789412
90Renovascular hypertension (HP:0100817)1.90190379
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89101387
92Low anterior hairline (HP:0000294)1.88662938
93Ulnar bowing (HP:0003031)1.88614037
94Renal dysplasia (HP:0000110)1.88041182
95Limited elbow extension (HP:0001377)1.87574711
96Vertebral arch anomaly (HP:0008438)1.87006284
97Subacute progressive viral hepatitis (HP:0006572)1.86718895
98Transitional cell carcinoma of the bladder (HP:0006740)1.85014683
99Chromsome breakage (HP:0040012)1.84178525
100Ectopic kidney (HP:0000086)1.83879677
101Abnormality of the lower motor neuron (HP:0002366)1.82946415
102Azoospermia (HP:0000027)1.82306413
103Sandal gap (HP:0001852)1.81381031
104Intestinal atresia (HP:0011100)1.80242986
105Abnormality of the hepatic vasculature (HP:0006707)1.79929737
106Gastrointestinal atresia (HP:0002589)1.78682179
107Impulsivity (HP:0100710)1.78555088
108Abnormal respiratory motile cilium morphology (HP:0005938)1.78252217
109Abnormal respiratory epithelium morphology (HP:0012253)1.78252217
110Abnormal spermatogenesis (HP:0008669)1.78135721
111Abnormal urine output (HP:0012590)1.77669973
112Leiomyosarcoma (HP:0100243)1.77486415
113Uterine leiomyosarcoma (HP:0002891)1.77486415
114Skin tags (HP:0010609)1.76694457
115Mixed hearing impairment (HP:0000410)1.76596731
116Esophageal atresia (HP:0002032)1.76305610
117Broad phalanges of the hand (HP:0009768)1.75566472
118Abnormality of the nasal septum (HP:0000419)1.75109155
119Abnormality of chromosome segregation (HP:0002916)1.74894633
120Aqueductal stenosis (HP:0002410)1.73840819
121Omphalocele (HP:0001539)1.73641865
122Progressive hearing impairment (HP:0001730)1.73225239
123Facial hemangioma (HP:0000329)1.71351456
124Metaphyseal cupping (HP:0003021)1.70922844
125Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70908879
126Drooling (HP:0002307)1.70362997
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70089108
128Elfin facies (HP:0004428)1.69851337
129Broad finger (HP:0001500)1.68226706
130Hypopigmentation of the fundus (HP:0007894)1.67734062
131Hypoplastic nipples (HP:0002557)1.67532701
132Exotropia (HP:0000577)1.67434425
133Abnormality of the epiphyses of the hand (HP:0005924)1.67431291
134Broad phalanx (HP:0006009)1.67181434
135Acute myeloid leukemia (HP:0004808)1.67027730
136Oligodontia (HP:0000677)1.66887740
137Deep philtrum (HP:0002002)1.66104281
138Shawl scrotum (HP:0000049)1.65981888
139Skull defect (HP:0001362)1.65869205
140Optic nerve hypoplasia (HP:0000609)1.65112625
141Broad long bones (HP:0005622)1.64512345
142Broad palm (HP:0001169)1.64449416
143Genu recurvatum (HP:0002816)1.64280193
144Short ribs (HP:0000773)1.63959959
145Vitreoretinal degeneration (HP:0000655)1.63525609
146Supernumerary bones of the axial skeleton (HP:0009144)1.63238356
147Pseudobulbar signs (HP:0002200)1.63154136
148Abnormality of the pubic bones (HP:0003172)1.62653312
149Tapered finger (HP:0001182)1.62357105
150Rib fusion (HP:0000902)1.61703291
151Short palm (HP:0004279)1.61173841
152Abnormality of chloride homeostasis (HP:0011422)1.61069058
153Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.60346938
154Selective tooth agenesis (HP:0001592)1.60178337
155Hypoplasia of the maxilla (HP:0000327)1.59924537
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.58151476
157Bowel incontinence (HP:0002607)1.57681809
158Hepatoblastoma (HP:0002884)1.57498736
159Abnormality of the antihelix (HP:0009738)1.57086758
160Vertebral clefting (HP:0008428)1.56937889
161Abnormality of the epiphysis of the femoral head (HP:0010574)1.56904504
162Abnormality of the 4th metacarpal (HP:0010012)1.56896311
163Neoplasm of striated muscle (HP:0009728)1.56582833
164Bladder carcinoma (HP:0002862)1.56514593
165Bladder neoplasm (HP:0009725)1.56514593
166Oligodactyly (hands) (HP:0001180)1.56084165
167Attention deficit hyperactivity disorder (HP:0007018)1.55473371
168Underdeveloped nasal alae (HP:0000430)1.54564431
169Laryngomalacia (HP:0001601)1.54529953
170Short humerus (HP:0005792)1.54007187
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.53891724
172Ankle contracture (HP:0006466)1.53872423
173Polycystic kidney dysplasia (HP:0000113)1.52872390
174Abnormality of renal excretion (HP:0011036)1.52845294
175Polyuria (HP:0000103)1.52510382
176Poor coordination (HP:0002370)1.50792917
177Scotoma (HP:0000575)1.50247120
178Abnormality of the renal cortex (HP:0011035)1.50143088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.85853142
2PLK45.49812241
3LATS14.52841171
4CAMK1D2.85594331
5CAMK1G2.58530406
6BRD42.53775729
7CDC72.44424255
8DYRK1B2.22019097
9STK32.14511382
10PLK22.10437737
11EEF2K2.09010923
12BMPR1B2.01360610
13STK38L2.00884016
14MTOR1.81534788
15SIK11.71068833
16NEK21.70087741
17LATS21.65833699
18FRK1.58883956
19PKN21.52190941
20PRKD31.51712787
21TTK1.51036619
22DDR21.48365292
23STK391.46075122
24PIK3CG1.45297040
25PDGFRA1.40646834
26NEK61.39121759
27CDK61.37126136
28PTK61.36272583
29ALK1.28394846
30PDGFRB1.25935105
31MAP4K21.25574756
32FGFR21.25266916
33MAP3K101.25155984
34CHEK11.22640033
35MAPK151.20650731
36STK101.16897408
37ATR1.16683615
38ATM1.15365611
39TAOK31.15206002
40STK381.12254777
41WNK41.11448750
42PDK11.10257411
43TRIB31.10115733
44CHEK21.09559339
45MST1R1.08533073
46TESK11.07798400
47AKT31.07637949
48TTN1.06764902
49ICK1.06480761
50PDPK11.05762868
51SGK31.05134463
52EPHA21.05105434
53WNK11.01835415
54MAP3K91.00475043
55TYRO31.00466143
56RPS6KB20.99872867
57PNCK0.99727652
58MET0.96936810
59PIM20.95873639
60SGK4940.93430331
61SGK2230.93430331
62OBSCN0.93384183
63DMPK0.92764593
64MAP3K40.92011960
65SIK20.90579278
66MKNK20.89814384
67CDK70.89616511
68CDK90.87972240
69* CDK20.87917181
70PTK2B0.87348079
71ACVR1B0.87022846
72CDK40.86349784
73NTRK30.84521029
74MAP3K20.84496998
75PIK3CA0.83823259
76CASK0.81119848
77FGFR30.80146752
78CSNK1D0.79535735
79FGFR10.79096884
80RIPK10.77637494
81SGK20.75771455
82CSNK1E0.75013327
83TGFBR10.74242159
84MAPK100.74090910
85PLK30.74000299
86* MAPK140.73119275
87* CDK10.71850971
88PTK20.71196207
89NEK10.70547230
90MARK20.70122922
91CDK30.68244725
92PRKDC0.68140147
93AURKB0.67482857
94PAK20.65918057
95PRKAA10.65311311
96ERBB40.65190672
97* GSK3B0.64783166
98PLK10.63583884
99MAP3K70.62853919
100STK40.62516555
101FER0.62356004
102MELK0.61782695
103MARK10.60660889
104RET0.60508098
105SGK10.60481908
106BMX0.60334723
107NUAK10.60127381
108PRKAA20.59398746
109SRPK10.59085283
110CAMK10.58803401
111AKT20.56535202
112NLK0.55503260
113TNIK0.54360450
114INSRR0.54057190
115TRPM70.51901513
116FLT30.51443083
117* MAPK10.51420699
118RPS6KA20.49871473
119PRKG10.49694804
120PASK0.47728740
121CDC42BPA0.47096026
122MAPK80.47062271
123CAMK40.46814023
124FGFR40.46652241
125KSR20.45687194
126ZAK0.45422457
127RPS6KB10.45419278
128TAOK10.45218559
129MAP3K80.44118745
130AKT10.44017359
131NEK90.43945463
132CDK80.43794978
133PRKD20.43574512
134MARK30.42803475
135MAP3K60.42310895
136BRSK20.42131909
137RPS6KA30.41363404
138PINK10.41186554
139CHUK0.39956219
140RPS6KA10.38813927
141MKNK10.38566895
142ROCK10.38219170
143RPS6KA60.32457425
144RPS6KC10.31406282

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.69116076
2Lysine degradation_Homo sapiens_hsa003102.94468636
3mTOR signaling pathway_Homo sapiens_hsa041501.90190991
4Adherens junction_Homo sapiens_hsa045201.85460996
5Olfactory transduction_Homo sapiens_hsa047401.84338772
6MicroRNAs in cancer_Homo sapiens_hsa052061.77216789
7mRNA surveillance pathway_Homo sapiens_hsa030151.74531826
8RNA transport_Homo sapiens_hsa030131.55922222
9One carbon pool by folate_Homo sapiens_hsa006701.53738434
10Cell cycle_Homo sapiens_hsa041101.52676618
11Thyroid hormone signaling pathway_Homo sapiens_hsa049191.51243986
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46159094
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45767284
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42748926
15Type II diabetes mellitus_Homo sapiens_hsa049301.36084156
16Small cell lung cancer_Homo sapiens_hsa052221.35939839
17Butanoate metabolism_Homo sapiens_hsa006501.33248564
18Non-homologous end-joining_Homo sapiens_hsa034501.32250123
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26967837
20Hippo signaling pathway_Homo sapiens_hsa043901.25123643
21Fatty acid metabolism_Homo sapiens_hsa012121.22072493
22ECM-receptor interaction_Homo sapiens_hsa045121.21680133
23Notch signaling pathway_Homo sapiens_hsa043301.21616312
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19719058
25Basal cell carcinoma_Homo sapiens_hsa052171.19567327
26Chronic myeloid leukemia_Homo sapiens_hsa052201.18850131
27Focal adhesion_Homo sapiens_hsa045101.17710681
28Dorso-ventral axis formation_Homo sapiens_hsa043201.17399866
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16019433
30Proteoglycans in cancer_Homo sapiens_hsa052051.15889024
31Prostate cancer_Homo sapiens_hsa052151.15754161
32Fanconi anemia pathway_Homo sapiens_hsa034601.13877178
33Taste transduction_Homo sapiens_hsa047421.13764799
34TGF-beta signaling pathway_Homo sapiens_hsa043501.13115428
35Endometrial cancer_Homo sapiens_hsa052131.12892711
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.12179881
37Glucagon signaling pathway_Homo sapiens_hsa049221.10258820
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08210538
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08169647
40Insulin resistance_Homo sapiens_hsa049311.07546168
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.06979352
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03654085
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03173744
44Nitrogen metabolism_Homo sapiens_hsa009101.01747067
45Colorectal cancer_Homo sapiens_hsa052101.01447937
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00958481
47Protein digestion and absorption_Homo sapiens_hsa049741.00008755
48AMPK signaling pathway_Homo sapiens_hsa041520.98088237
49Inositol phosphate metabolism_Homo sapiens_hsa005620.97589686
50Fatty acid degradation_Homo sapiens_hsa000710.97195612
51Glioma_Homo sapiens_hsa052140.96884418
52Wnt signaling pathway_Homo sapiens_hsa043100.95056591
53FoxO signaling pathway_Homo sapiens_hsa040680.94162015
54ABC transporters_Homo sapiens_hsa020100.94097616
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94046922
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93546033
57Non-small cell lung cancer_Homo sapiens_hsa052230.93059243
58Viral carcinogenesis_Homo sapiens_hsa052030.92802915
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92764577
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92375163
61p53 signaling pathway_Homo sapiens_hsa041150.90620899
62Tight junction_Homo sapiens_hsa045300.89893935
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.89771656
64Caffeine metabolism_Homo sapiens_hsa002320.89462007
65Calcium signaling pathway_Homo sapiens_hsa040200.88325475
66Selenocompound metabolism_Homo sapiens_hsa004500.87630001
67ErbB signaling pathway_Homo sapiens_hsa040120.87352876
68Pancreatic cancer_Homo sapiens_hsa052120.86206221
69cAMP signaling pathway_Homo sapiens_hsa040240.83934003
70Cholinergic synapse_Homo sapiens_hsa047250.82320966
71Estrogen signaling pathway_Homo sapiens_hsa049150.82023130
72Phototransduction_Homo sapiens_hsa047440.81566156
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80999256
74Vitamin B6 metabolism_Homo sapiens_hsa007500.80659667
75Prolactin signaling pathway_Homo sapiens_hsa049170.80639752
76Renin secretion_Homo sapiens_hsa049240.77121501
77Fatty acid biosynthesis_Homo sapiens_hsa000610.76724116
78RNA degradation_Homo sapiens_hsa030180.76367508
79Oocyte meiosis_Homo sapiens_hsa041140.75976850
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75466611
81HTLV-I infection_Homo sapiens_hsa051660.74836816
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.74611055
83Pathways in cancer_Homo sapiens_hsa052000.74431906
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73555975
85Choline metabolism in cancer_Homo sapiens_hsa052310.73246909
86VEGF signaling pathway_Homo sapiens_hsa043700.72174079
87Insulin signaling pathway_Homo sapiens_hsa049100.70869723
88Oxytocin signaling pathway_Homo sapiens_hsa049210.70000949
89PPAR signaling pathway_Homo sapiens_hsa033200.69871595
90Dilated cardiomyopathy_Homo sapiens_hsa054140.68234397
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67233510
92Melanoma_Homo sapiens_hsa052180.66560480
93Hedgehog signaling pathway_Homo sapiens_hsa043400.66380090
94Thyroid cancer_Homo sapiens_hsa052160.66282402
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65862636
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63894108
97Rap1 signaling pathway_Homo sapiens_hsa040150.63754064
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63552775
99Renal cell carcinoma_Homo sapiens_hsa052110.63417659
100Long-term potentiation_Homo sapiens_hsa047200.63088421
101Circadian entrainment_Homo sapiens_hsa047130.61403136
102Spliceosome_Homo sapiens_hsa030400.60641463
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60024472
104Thyroid hormone synthesis_Homo sapiens_hsa049180.59825539
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59385815
106Glutamatergic synapse_Homo sapiens_hsa047240.59248888
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.58988426
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57749789
109Salivary secretion_Homo sapiens_hsa049700.56782052
110Insulin secretion_Homo sapiens_hsa049110.56718267
111Propanoate metabolism_Homo sapiens_hsa006400.55006702
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54939602
113Basal transcription factors_Homo sapiens_hsa030220.54157940
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54028506
115Systemic lupus erythematosus_Homo sapiens_hsa053220.53813290
116Vitamin digestion and absorption_Homo sapiens_hsa049770.53624556
117Renin-angiotensin system_Homo sapiens_hsa046140.53495492
118Bladder cancer_Homo sapiens_hsa052190.52926132
119Circadian rhythm_Homo sapiens_hsa047100.52752168
120MAPK signaling pathway_Homo sapiens_hsa040100.51536198
121Acute myeloid leukemia_Homo sapiens_hsa052210.51360192
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.51005170
123Axon guidance_Homo sapiens_hsa043600.50977076
124HIF-1 signaling pathway_Homo sapiens_hsa040660.50899217
125Nicotine addiction_Homo sapiens_hsa050330.49511588
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49218809
127Long-term depression_Homo sapiens_hsa047300.49170106
128Gastric acid secretion_Homo sapiens_hsa049710.48808134
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47100897
130Pancreatic secretion_Homo sapiens_hsa049720.46774806
131Melanogenesis_Homo sapiens_hsa049160.46481791
132Amoebiasis_Homo sapiens_hsa051460.45423365
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.44845934
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44808212

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