GIMAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.87446434
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.55926234
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.55926234
4ribosomal small subunit assembly (GO:0000028)6.21645384
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.08631296
6antigen processing and presentation of endogenous antigen (GO:0019883)5.90982399
7regulation of gamma-delta T cell differentiation (GO:0045586)5.66262727
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.37164923
9regulation of gamma-delta T cell activation (GO:0046643)5.16193748
10antigen processing and presentation via MHC class Ib (GO:0002475)4.91513086
11negative T cell selection (GO:0043383)4.65081113
12negative thymic T cell selection (GO:0045060)4.62147002
13negative regulation of lymphocyte mediated immunity (GO:0002707)4.51855444
14activated T cell proliferation (GO:0050798)4.47442899
15viral transcription (GO:0019083)4.46642916
16response to interleukin-15 (GO:0070672)4.43434569
17positive thymic T cell selection (GO:0045059)4.34855379
18regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.33799810
19negative regulation of T cell mediated immunity (GO:0002710)4.28680202
20regulation of regulatory T cell differentiation (GO:0045589)4.26385584
21interferon-gamma production (GO:0032609)4.25439265
22translational termination (GO:0006415)4.23037504
23cellular response to interleukin-15 (GO:0071350)4.20934655
24positive regulation by symbiont of host defense response (GO:0052509)4.20533986
25modulation by symbiont of host defense response (GO:0052031)4.20533986
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.20533986
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.20533986
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.20533986
29modulation by symbiont of host immune response (GO:0052553)4.20533986
30tolerance induction (GO:0002507)4.16750037
31regulation of B cell receptor signaling pathway (GO:0050855)4.13598881
32neutrophil activation involved in immune response (GO:0002283)4.13277668
33regulation of T cell tolerance induction (GO:0002664)4.11669156
34T cell migration (GO:0072678)4.07873526
35detection of other organism (GO:0098543)4.05930658
36negative regulation of leukocyte mediated immunity (GO:0002704)4.00178522
37regulation of isotype switching to IgG isotypes (GO:0048302)4.00165154
38detection of bacterium (GO:0016045)3.98808662
39thymic T cell selection (GO:0045061)3.85786368
40mature B cell differentiation involved in immune response (GO:0002313)3.85337279
41B cell receptor signaling pathway (GO:0050853)3.84998881
42leukocyte aggregation (GO:0070486)3.83575692
43definitive hemopoiesis (GO:0060216)3.81570043
44T cell homeostasis (GO:0043029)3.76696518
45mast cell activation (GO:0045576)3.75491483
46negative regulation of interleukin-12 production (GO:0032695)3.75186110
47lymph node development (GO:0048535)3.74729232
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.74004564
49translational elongation (GO:0006414)3.73035821
50response to interferon-beta (GO:0035456)3.72349915
51defense response to protozoan (GO:0042832)3.71249979
52regulation of B cell differentiation (GO:0045577)3.69857838
53mature B cell differentiation (GO:0002335)3.65592927
54positive T cell selection (GO:0043368)3.65230299
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.64087128
56T cell selection (GO:0045058)3.63546184
57negative regulation of erythrocyte differentiation (GO:0045647)3.63420288
58macrophage activation involved in immune response (GO:0002281)3.61947370
59positive regulation of B cell differentiation (GO:0045579)3.61095697
60ribosomal small subunit biogenesis (GO:0042274)3.60903981
61response to protozoan (GO:0001562)3.60578377
62immunoglobulin mediated immune response (GO:0016064)3.59557458
63cellular extravasation (GO:0045123)3.58838538
64antigen receptor-mediated signaling pathway (GO:0050851)3.58348320
65maturation of SSU-rRNA (GO:0030490)3.58049288
66positive regulation of T cell mediated cytotoxicity (GO:0001916)3.57536829
67neutrophil activation (GO:0042119)3.56381029
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53013478
69T cell receptor signaling pathway (GO:0050852)3.52092168
70cotranslational protein targeting to membrane (GO:0006613)3.44053031
71mucosal-associated lymphoid tissue development (GO:0048537)3.43406564
72Peyers patch development (GO:0048541)3.43406564
73protein targeting to ER (GO:0045047)3.42261229
74response to type I interferon (GO:0034340)3.42203940
75positive regulation of tolerance induction (GO:0002645)3.41873097
76regulation of T cell receptor signaling pathway (GO:0050856)3.39782520
77dendritic cell chemotaxis (GO:0002407)3.39755808
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.39359897
79type I interferon signaling pathway (GO:0060337)3.36558710
80cellular response to type I interferon (GO:0071357)3.36558710
81regulation of leukocyte mediated cytotoxicity (GO:0001910)3.36306140
82regulation of alpha-beta T cell proliferation (GO:0046640)3.35273013
83respiratory burst (GO:0045730)3.33313166
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30662511
85DNA deamination (GO:0045006)3.30522544
86dendritic cell migration (GO:0036336)3.30096959
87lymphocyte costimulation (GO:0031294)3.29195848
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27717268
89viral life cycle (GO:0019058)3.27594900
90Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25776248
91protein localization to endoplasmic reticulum (GO:0070972)3.25516116
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24767253
93positive regulation of granulocyte differentiation (GO:0030854)3.24609676
94platelet dense granule organization (GO:0060155)3.23504047
95T cell costimulation (GO:0031295)3.23310140
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23065614
97detection of external biotic stimulus (GO:0098581)3.22966139
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20789798
99negative regulation of cell killing (GO:0031342)3.20789798
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20776310
101microglial cell activation (GO:0001774)3.19934546
102granulocyte activation (GO:0036230)3.19603115
103myeloid cell activation involved in immune response (GO:0002275)3.19017425
104CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17382898
105NIK/NF-kappaB signaling (GO:0038061)3.17016827
106mast cell activation involved in immune response (GO:0002279)3.15357993
107mast cell degranulation (GO:0043303)3.15357993
108positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.14706684
109negative regulation of innate immune response (GO:0045824)3.14323211
110negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14124693
111regulation of interferon-beta biosynthetic process (GO:0045357)3.12666996
112positive regulation of isotype switching (GO:0045830)3.12554522
113cellular protein complex disassembly (GO:0043624)3.11867408
114negative regulation of phagocytosis (GO:0050765)3.10131767
115response to peptidoglycan (GO:0032494)3.08851238
116lymphocyte homeostasis (GO:0002260)3.03042354
117regulation of cell killing (GO:0031341)3.02906336
118regulation of T cell mediated cytotoxicity (GO:0001914)3.02779265
119myeloid dendritic cell activation (GO:0001773)3.01227781
120megakaryocyte development (GO:0035855)3.00996814
121regulation of tolerance induction (GO:0002643)3.00316469
122interferon-gamma-mediated signaling pathway (GO:0060333)2.98863881
123leukocyte degranulation (GO:0043299)2.98744763
124positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97960034
125* T cell differentiation (GO:0030217)2.93146292
126leukocyte homeostasis (GO:0001776)2.92207756
127positive regulation of humoral immune response (GO:0002922)2.92118985
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91508814
129response to host immune response (GO:0052572)2.91508814
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90507405
131negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90418116
132negative regulation of T-helper cell differentiation (GO:0045623)2.90418116
133positive regulation of T cell differentiation in thymus (GO:0033089)2.90192491
134regulation of T cell mediated immunity (GO:0002709)2.89991302
135positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.89557450
136positive regulation of natural killer cell mediated immunity (GO:0002717)2.89557450
137production of molecular mediator involved in inflammatory response (GO:0002532)2.89432474
138regulation of response to interferon-gamma (GO:0060330)2.89138138
139negative regulation of adaptive immune response (GO:0002820)2.88502367
140cellular response to interferon-beta (GO:0035458)2.88020698
141positive regulation of mast cell activation (GO:0033005)2.87600466
142negative regulation of type 2 immune response (GO:0002829)2.87346645
143positive regulation of DNA recombination (GO:0045911)2.87185592
144positive regulation of interleukin-2 production (GO:0032743)2.87039970
145regulation of natural killer cell mediated immunity (GO:0002715)2.86851514
146regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86851514
147regulation of interleukin-2 biosynthetic process (GO:0045076)2.86165594
148regulation of necroptotic process (GO:0060544)2.85202412
149translational initiation (GO:0006413)2.84936843
150regulation of alpha-beta T cell activation (GO:0046634)2.84420918
151natural killer cell activation (GO:0030101)2.83765732
152regulation of granulocyte differentiation (GO:0030852)2.82169871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.82054109
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.53694934
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.17754046
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.13091980
5SCL_19346495_ChIP-Seq_HPC-7_Human3.59841940
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49197306
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.34606235
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.24193323
9MYC_22102868_ChIP-Seq_BL_Human3.24164883
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.20420135
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.96117034
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80650709
13E2F7_22180533_ChIP-Seq_HELA_Human2.79557095
14RUNX_20019798_ChIP-Seq_JUKART_Human2.67692087
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65467455
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.63597931
17MYB_26560356_Chip-Seq_TH2_Human2.59562290
18* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.59472216
19* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.50280546
20* NOTCH1_21737748_ChIP-Seq_TLL_Human2.48064336
21MAF_26560356_Chip-Seq_TH1_Human2.46688337
22VDR_21846776_ChIP-Seq_THP-1_Human2.45500488
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43747702
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28329444
25SPI1_23547873_ChIP-Seq_NB4_Human2.28130562
26MYB_26560356_Chip-Seq_TH1_Human2.27448784
27UTX_26944678_Chip-Seq_JUKART_Human2.24901451
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.24487874
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17243838
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.07334007
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.06717281
32* RUNX1_22412390_ChIP-Seq_EML_Mouse2.01360021
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94158395
34* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.90281422
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87318973
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87282778
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.87124390
38VDR_24763502_ChIP-Seq_THP-1_Human1.86900176
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86327186
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86189181
41* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82856409
42* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82329408
43TCF7_22412390_ChIP-Seq_EML_Mouse1.78876359
44MAF_26560356_Chip-Seq_TH2_Human1.76264418
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74961192
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.72857892
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.71839722
48* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70997104
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70331290
50CIITA_25753668_ChIP-Seq_RAJI_Human1.70145536
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69905475
52VDR_23849224_ChIP-Seq_CD4+_Human1.69769825
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.66192156
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.64537946
55VDR_24787735_ChIP-Seq_THP-1_Human1.56251621
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54581653
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53465573
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52074576
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48383262
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.44982265
61GATA3_27048872_Chip-Seq_THYMUS_Human1.44467478
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38142190
63SPI1_23127762_ChIP-Seq_K562_Human1.37905256
64GATA1_22025678_ChIP-Seq_K562_Human1.36938859
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.36524042
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.34084251
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32453541
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31605185
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30095200
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27229076
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27108067
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24240781
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23798609
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20725601
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18236278
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18211648
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17366231
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.17055030
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16865241
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16137612
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.16106479
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14029302
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13843082
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.12820146
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12051246
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11971124
87XRN2_22483619_ChIP-Seq_HELA_Human1.09512651
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09439792
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09369707
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08724988
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.08114270
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06793450
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06201363
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04348262
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03780524
96PU_27001747_Chip-Seq_BMDM_Mouse1.03222119
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02295178
98E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01716191
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00167543
100GATA1_19941826_ChIP-Seq_K562_Human0.99923875
101GATA3_26560356_Chip-Seq_TH2_Human0.99620558
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99376149
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98630706
104ELK1_19687146_ChIP-ChIP_HELA_Human0.97444980
105KDM2B_26808549_Chip-Seq_DND41_Human0.97371315
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.95551472
107RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95451102
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94976556
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94711304
110MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93039191
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92820882
112MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92532253
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91371927
114SMRT_27268052_Chip-Seq_Bcells_Human0.90350046
115KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90229098
116GABP_19822575_ChIP-Seq_HepG2_Human0.88491860
117* BCOR_27268052_Chip-Seq_Bcells_Human0.88120655
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86642928
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85038517
120* BCL6_27268052_Chip-Seq_Bcells_Human0.83659278
121GATA3_26560356_Chip-Seq_TH1_Human0.83272304
122SPI1_20517297_ChIP-Seq_HL60_Human0.83164911
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.81440471
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.81341860
125TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80716423
126DCP1A_22483619_ChIP-Seq_HELA_Human0.79682088
127RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78223730
128* P300_27268052_Chip-Seq_Bcells_Human0.77209810
129GATA2_19941826_ChIP-Seq_K562_Human0.76871705
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74208595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.20340090
2MP0000685_abnormal_immune_system4.20236540
3MP0001835_abnormal_antigen_presentation4.10843012
4MP0003763_abnormal_thymus_physiology4.09487647
5MP0001800_abnormal_humoral_immune3.29940524
6MP0002396_abnormal_hematopoietic_system3.22734894
7MP0009785_altered_susceptibility_to3.07272034
8MP0001873_stomach_inflammation2.99805546
9MP0005387_immune_system_phenotype2.99779340
10MP0001790_abnormal_immune_system2.99779340
11* MP0002398_abnormal_bone_marrow2.79939487
12MP0002723_abnormal_immune_serum2.79732935
13* MP0002420_abnormal_adaptive_immunity2.77577172
14MP0002452_abnormal_antigen_presenting2.75298119
15* MP0001819_abnormal_immune_cell2.73492616
16MP0005000_abnormal_immune_tolerance2.64693838
17MP0005025_abnormal_response_to2.60580789
18MP0004808_abnormal_hematopoietic_stem2.52847175
19* MP0000716_abnormal_immune_system2.43434811
20MP0003724_increased_susceptibility_to2.42056048
21MP0003866_abnormal_defecation2.40338410
22* MP0000689_abnormal_spleen_morphology2.32851386
23MP0010155_abnormal_intestine_physiology2.32022831
24MP0002722_abnormal_immune_system2.30356407
25MP0002166_altered_tumor_susceptibility2.29083792
26MP0003436_decreased_susceptibility_to2.25946275
27MP0005464_abnormal_platelet_physiology2.25926667
28MP0004510_myositis2.19366953
29MP0009333_abnormal_splenocyte_physiolog2.19266524
30MP0002148_abnormal_hypersensitivity_rea2.18007600
31* MP0002429_abnormal_blood_cell2.08947342
32MP0006082_CNS_inflammation2.04749641
33* MP0000703_abnormal_thymus_morphology2.03250850
34MP0002405_respiratory_system_inflammati1.99707823
35MP0005075_abnormal_melanosome_morpholog1.99153375
36MP0002419_abnormal_innate_immunity1.91305539
37MP0000465_gastrointestinal_hemorrhage1.89256824
38MP0005397_hematopoietic_system_phenotyp1.78166432
39MP0001545_abnormal_hematopoietic_system1.78166432
40MP0002006_tumorigenesis1.75888992
41MP0002933_joint_inflammation1.70951182
42MP0000490_abnormal_crypts_of1.70277699
43MP0001853_heart_inflammation1.69037318
44MP0004947_skin_inflammation1.66789857
45MP0001845_abnormal_inflammatory_respons1.65208977
46MP0005174_abnormal_tail_pigmentation1.61635704
47MP0003300_gastrointestinal_ulcer1.41109558
48MP0009278_abnormal_bone_marrow1.33683992
49MP0003172_abnormal_lysosome_physiology1.27739529
50MP0008469_abnormal_protein_level1.25076252
51MP0002277_abnormal_respiratory_mucosa1.22573181
52MP0001851_eye_inflammation1.20217419
53MP0005310_abnormal_salivary_gland1.20011279
54MP0002095_abnormal_skin_pigmentation1.19111181
55MP0004883_abnormal_blood_vessel1.18933712
56MP0008058_abnormal_DNA_repair1.18433139
57MP0001986_abnormal_taste_sensitivity1.17045238
58MP0008260_abnormal_autophagy1.12135507
59MP0003690_abnormal_glial_cell1.11693578
60MP0002019_abnormal_tumor_incidence1.09784985
61MP0004130_abnormal_muscle_cell1.06343718
62MP0003943_abnormal_hepatobiliary_system1.06024827
63MP0002132_abnormal_respiratory_system1.04530668
64MP0002009_preneoplasia1.02606033
65MP0002138_abnormal_hepatobiliary_system0.99001853
66MP0001533_abnormal_skeleton_physiology0.98349502
67MP0009379_abnormal_foot_pigmentation0.94563804
68MP0009764_decreased_sensitivity_to0.91945577
69MP0004381_abnormal_hair_follicle0.84286539
70MP0010368_abnormal_lymphatic_system0.83555518
71MP0003303_peritoneal_inflammation0.83344026
72MP0000604_amyloidosis0.83220165
73MP0001663_abnormal_digestive_system0.82735967
74MP0004147_increased_porphyrin_level0.81442463
75MP0008007_abnormal_cellular_replicative0.80908064
76MP0000858_altered_metastatic_potential0.80661322
77MP0003183_abnormal_peptide_metabolism0.79238473
78MP0003077_abnormal_cell_cycle0.77660912
79MP0005164_abnormal_response_to0.76969689
80MP0005390_skeleton_phenotype0.76661212
81MP0000477_abnormal_intestine_morphology0.76202288
82MP0010094_abnormal_chromosome_stability0.74810861
83MP0001879_abnormal_lymphatic_vessel0.74154238
84MP0003828_pulmonary_edema0.72889745
85MP0003075_altered_response_to0.72841516
86MP0009763_increased_sensitivity_to0.72269869
87MP0003693_abnormal_embryo_hatching0.72212562
88MP0009765_abnormal_xenobiotic_induced0.69839784
89MP0005058_abnormal_lysosome_morphology0.67040059
90MP0003191_abnormal_cellular_cholesterol0.66855319
91MP0006054_spinal_hemorrhage0.66480172
92MP0002998_abnormal_bone_remodeling0.66210375
93MP0000015_abnormal_ear_pigmentation0.65778996
94MP0000313_abnormal_cell_death0.64873524
95MP0001348_abnormal_lacrimal_gland0.63473664
96MP0003011_delayed_dark_adaptation0.62472977
97MP0008057_abnormal_DNA_replication0.62108020
98MP0000343_altered_response_to0.60711327
99MP0003448_altered_tumor_morphology0.60523973
100MP0005409_darkened_coat_color0.57720727
101MP0005166_decreased_susceptibility_to0.57434144
102MP0008874_decreased_physiological_sensi0.56535035
103MP0005167_abnormal_blood-brain_barrier0.54726730
104MP0008004_abnormal_stomach_pH0.53656248
105MP0004957_abnormal_blastocyst_morpholog0.53154854
106MP0004484_altered_response_of0.52165531
107MP0005023_abnormal_wound_healing0.52140323
108MP0002928_abnormal_bile_duct0.51978135
109MP0005451_abnormal_body_composition0.51262735
110MP0003252_abnormal_bile_duct0.50677671
111MP0003868_abnormal_feces_composition0.50070421
112MP0001191_abnormal_skin_condition0.49737949
113MP0000249_abnormal_blood_vessel0.48759460
114MP0002075_abnormal_coat/hair_pigmentati0.48540375
115MP0002136_abnormal_kidney_physiology0.47692876
116MP0003786_premature_aging0.47447393
117MP0005381_digestive/alimentary_phenotyp0.46392582
118MP0005535_abnormal_body_temperature0.46313521
119MP0003795_abnormal_bone_structure0.45324735
120MP0002693_abnormal_pancreas_physiology0.44936071
121MP0008877_abnormal_DNA_methylation0.43406802
122MP0000598_abnormal_liver_morphology0.43341842
123MP0010352_gastrointestinal_tract_polyps0.43222896
124MP0003806_abnormal_nucleotide_metabolis0.42225484
125MP0009115_abnormal_fat_cell0.41574823
126MP0005334_abnormal_fat_pad0.41560453
127MP0001765_abnormal_ion_homeostasis0.40685477
128MP0002083_premature_death0.39096524
129MP0003045_fibrosis0.37877829

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.52711262
2Recurrent bronchitis (HP:0002837)5.02327348
3Thrombocytosis (HP:0001894)4.80912945
4Elevated erythrocyte sedimentation rate (HP:0003565)4.78591678
5Chronic otitis media (HP:0000389)4.77739940
6Abnormality of macrophages (HP:0004311)4.67774959
7Panhypogammaglobulinemia (HP:0003139)4.56994639
8Agammaglobulinemia (HP:0004432)4.41909285
9Abnormality of the nasal mucosa (HP:0000433)4.29581259
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.26563324
11Nasal polyposis (HP:0100582)4.24052911
12Abnormality of T cells (HP:0002843)4.19047104
13Myositis (HP:0100614)4.17870781
14Recurrent gram-negative bacterial infections (HP:0005420)4.12700937
15T lymphocytopenia (HP:0005403)4.02329508
16IgG deficiency (HP:0004315)4.00155834
17Abnormality of T cell physiology (HP:0011840)3.93130092
18Gastrointestinal infarctions (HP:0005244)3.89343651
19Abnormality of T cell number (HP:0011839)3.86071992
20Chronic obstructive pulmonary disease (HP:0006510)3.63985870
21Obstructive lung disease (HP:0006536)3.63985870
22Recurrent viral infections (HP:0004429)3.63032359
23Prolonged bleeding time (HP:0003010)3.57335228
24Severe combined immunodeficiency (HP:0004430)3.56424990
25Lymphopenia (HP:0001888)3.54628785
26Recurrent fungal infections (HP:0002841)3.47006266
27Abnormality of cells of the erythroid lineage (HP:0012130)3.44070532
28Gastrointestinal stroma tumor (HP:0100723)3.41451362
29Meningitis (HP:0001287)3.39021970
30Abnormality of B cell number (HP:0010975)3.38261958
31B lymphocytopenia (HP:0010976)3.38261958
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.35498321
33Keratoconjunctivitis sicca (HP:0001097)3.29243771
34Inflammation of the large intestine (HP:0002037)3.28437172
35Aplastic anemia (HP:0001915)3.27694860
36Abnormal number of erythroid precursors (HP:0012131)3.27503882
37Gastrointestinal inflammation (HP:0004386)3.27385876
38Keratoconjunctivitis (HP:0001096)3.26723530
39Combined immunodeficiency (HP:0005387)3.18742236
40Thyroiditis (HP:0100646)3.16275116
41Stomatitis (HP:0010280)3.12043218
42Petechiae (HP:0000967)3.11868659
43Chronic mucocutaneous candidiasis (HP:0002728)3.11651739
44Recurrent cutaneous fungal infections (HP:0011370)3.11651739
45Spontaneous hematomas (HP:0007420)3.10974351
46Cellulitis (HP:0100658)3.10541634
47Recurrent sinusitis (HP:0011108)3.10394988
48Chronic diarrhea (HP:0002028)3.06522285
49Gingivitis (HP:0000230)2.96487713
50Chronic sinusitis (HP:0011109)2.95992019
51Eczematoid dermatitis (HP:0000976)2.91694016
52IgA deficiency (HP:0002720)2.90764088
53Epistaxis (HP:0000421)2.89857104
54Urticaria (HP:0001025)2.88469372
55Abnormality of the fingertips (HP:0001211)2.88450477
56Poikiloderma (HP:0001029)2.86085595
57Colitis (HP:0002583)2.84756220
58Type 2 muscle fiber atrophy (HP:0003554)2.84104382
59Vasculitis (HP:0002633)2.84048314
60Bronchitis (HP:0012387)2.83675441
61Muscle fiber atrophy (HP:0100295)2.80246266
62Hypochromic anemia (HP:0001931)2.80172041
63Hypochromic microcytic anemia (HP:0004840)2.77358224
64Recurrent abscess formation (HP:0002722)2.73544810
65Lymphoma (HP:0002665)2.71830945
66Episodic fever (HP:0001954)2.71216174
67Encephalitis (HP:0002383)2.70430631
68Reticulocytopenia (HP:0001896)2.64339512
69Pulmonary embolism (HP:0002204)2.63718749
70Autoimmune hemolytic anemia (HP:0001890)2.62598944
71Increased IgM level (HP:0003496)2.54348344
72Hematochezia (HP:0002573)2.52498007
73Abnormality of eosinophils (HP:0001879)2.51404636
74Amaurosis fugax (HP:0100576)2.50302254
75Orchitis (HP:0100796)2.47369642
76Anorexia (HP:0002039)2.45730494
77Optic neuritis (HP:0100653)2.45359713
78Retrobulbar optic neuritis (HP:0100654)2.45359713
79Impaired platelet aggregation (HP:0003540)2.40190631
80Abnormal platelet function (HP:0011869)2.40190631
81Microcytic anemia (HP:0001935)2.40023708
82Increased IgE level (HP:0003212)2.40015175
83Recurrent skin infections (HP:0001581)2.38407621
84Hypergammaglobulinemia (HP:0010702)2.34762723
85Hypoproteinemia (HP:0003075)2.31971338
86Granulocytopenia (HP:0001913)2.30930240
87Stomach cancer (HP:0012126)2.30773616
88Abnormality of the pleura (HP:0002103)2.29098568
89Emphysema (HP:0002097)2.28839201
90Interstitial pulmonary disease (HP:0006530)2.28405711
91Pustule (HP:0200039)2.27923130
92Autoimmune thrombocytopenia (HP:0001973)2.27047867
93Entropion (HP:0000621)2.26203291
94Leukocytosis (HP:0001974)2.26182519
95Recurrent bacterial skin infections (HP:0005406)2.26024152
96Papilloma (HP:0012740)2.20762760
97Verrucae (HP:0200043)2.20762760
98Hemoptysis (HP:0002105)2.17189308
99Papilledema (HP:0001085)2.17019632
100Sepsis (HP:0100806)2.15048499
101Hypoplasia of the thymus (HP:0000778)2.14579497
102Pallor (HP:0000980)2.13342585
103Gingival bleeding (HP:0000225)2.13288017
104Arterial thrombosis (HP:0004420)2.12864479
105Hemiplegia (HP:0002301)2.12425365
106Chest pain (HP:0100749)2.12069616
107Joint swelling (HP:0001386)2.11759744
108Gangrene (HP:0100758)2.11349510
109Eosinophilia (HP:0001880)2.10526565
110Purpura (HP:0000979)2.09134546
111Basal cell carcinoma (HP:0002671)2.08678452
112Osteomyelitis (HP:0002754)2.06818671
113Mediastinal lymphadenopathy (HP:0100721)2.06754673
114Neutropenia (HP:0001875)2.04345592
115Abnormality of the prostate (HP:0008775)2.00632239
116Macrocytic anemia (HP:0001972)1.99498109
117Keratitis (HP:0000491)1.99291508
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95542256
119Acute hepatic failure (HP:0006554)1.94713724
120Nonprogressive disorder (HP:0003680)1.94562003
121Skin rash (HP:0000988)1.94379102
122Glomerulopathy (HP:0100820)1.93405691
123Vertigo (HP:0002321)1.92739168
124Recurrent otitis media (HP:0000403)1.89614983
125Pulmonary infiltrates (HP:0002113)1.89536862
126Weak cry (HP:0001612)1.88821493
127Premature loss of primary teeth (HP:0006323)1.87573441
128Abnormality of the endocardium (HP:0004306)1.83110687
129Skin ulcer (HP:0200042)1.82753471
130Polyneuropathy (HP:0001271)1.80941904
131Acne (HP:0001061)1.80208809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.42629044
2TXK3.94816487
3KIT2.97725714
4ZAP702.66877187
5NME22.51103510
6JAK32.46379982
7KDR2.43455019
8TEC2.36403594
9BTK2.30896732
10IKBKE2.30620015
11MAP2K32.29982964
12TGFBR12.09385636
13TGFBR22.04065756
14TBK11.94474579
15NLK1.90806417
16SYK1.85427507
17MUSK1.84847060
18EEF2K1.79896417
19MAP3K121.77324837
20PRPF4B1.72827666
21TIE11.72691689
22BLK1.69405779
23CSF1R1.64039562
24MAP3K141.61324843
25TYK21.60161171
26ITK1.58524266
27LCK1.50870266
28FGR1.49100436
29CDK191.46438894
30FLT31.44824526
31EPHB11.42908151
32MAP3K101.42688840
33GRK61.39169199
34IRAK41.31632333
35IKBKB1.30630276
36FGFR41.29110420
37STK101.28447573
38ERN11.21117856
39HCK1.13968984
40PRKD21.12780860
41LYN1.12094862
42TNIK1.10270759
43STK161.07868499
44LRRK21.07206905
45CAMKK11.06849576
46ACVR1B1.05418359
47JAK11.02385944
48MAP3K30.96140877
49RPS6KB20.95960767
50CSK0.95159437
51TNK20.92403402
52MAP3K130.89891750
53FES0.89095799
54RPS6KA40.86890124
55TAOK10.86387157
56FGFR30.85474492
57PIM10.85352211
58PKN20.84881417
59MYLK0.84554735
60SIK30.83732482
61PRKCH0.81525104
62MAPK120.77217528
63MAP3K10.75197317
64MAP2K60.73295692
65MAP2K20.73259187
66MST40.70717463
67TESK20.70451260
68MAPK70.69774739
69YES10.69313569
70CLK10.68809403
71GRK70.68346690
72FYN0.67843293
73SIK20.67579538
74ADRBK20.64540640
75MAP3K70.64501439
76MATK0.63400106
77CHUK0.63229638
78BMPR20.61168276
79TRIB30.59831646
80CDK90.59629460
81HIPK20.58889957
82CAMKK20.57668107
83IRAK30.56468408
84PRKG20.55531632
85PASK0.55487038
86PIK3CG0.55328798
87MKNK10.53563404
88IRAK10.52111569
89PTK2B0.51955135
90EIF2AK30.51161057
91CDK80.51010480
92SRPK10.50912090
93ILK0.49269857
94CDC42BPA0.48257976
95CDK40.47449015
96PTK60.46072570
97TAOK30.44752935
98PRKCQ0.44643164
99STK110.44061469
100RPS6KA50.43019622
101GRK50.42502776
102MAPKAPK50.41796582
103MAPK40.39919923
104JAK20.39064987
105MAP2K70.38868353
106VRK10.38595607
107CAMK10.38577174
108KSR20.38325890
109PDK10.38199995
110BRD40.38041579
111PDPK10.36526283
112DYRK1B0.36096411
113CDK30.35322405
114TYRO30.34947134
115MAPK110.34776638
116MARK20.33531464
117ABL10.32219928
118MARK30.31407135
119FRK0.30851876
120MAP3K110.30550473
121SGK30.30155380
122RET0.29261396
123GRK10.29127381
124EPHA30.28929604
125RIPK40.28388814
126RPS6KA60.28051706
127SGK20.27888322
128STK380.27350019
129EGFR0.27059450
130MAPKAPK20.26727122
131RPS6KL10.26357428
132RPS6KC10.26357428
133EIF2AK10.26254027
134BCKDK0.26225923
135INSR0.25600854
136CAMK40.25307411
137PIM20.24992344

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.40805787
2Ribosome_Homo sapiens_hsa030103.51068888
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.76849374
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.62219263
5B cell receptor signaling pathway_Homo sapiens_hsa046622.59703509
6T cell receptor signaling pathway_Homo sapiens_hsa046602.49740717
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43292312
8Measles_Homo sapiens_hsa051622.36715335
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.33013011
10Allograft rejection_Homo sapiens_hsa053302.30830608
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30518193
12Hematopoietic cell lineage_Homo sapiens_hsa046402.28673054
13Antigen processing and presentation_Homo sapiens_hsa046122.24397697
14DNA replication_Homo sapiens_hsa030302.14641186
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92142659
16Mismatch repair_Homo sapiens_hsa034301.74020889
17Leishmaniasis_Homo sapiens_hsa051401.73463737
18Herpes simplex infection_Homo sapiens_hsa051681.71861469
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.71857166
20Base excision repair_Homo sapiens_hsa034101.63220888
21Osteoclast differentiation_Homo sapiens_hsa043801.56431953
22Graft-versus-host disease_Homo sapiens_hsa053321.52709639
23Acute myeloid leukemia_Homo sapiens_hsa052211.45601186
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43618452
25Autoimmune thyroid disease_Homo sapiens_hsa053201.42616123
26Asthma_Homo sapiens_hsa053101.39900287
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37984531
28Platelet activation_Homo sapiens_hsa046111.31155358
29Spliceosome_Homo sapiens_hsa030401.27979954
30Shigellosis_Homo sapiens_hsa051311.25904594
31RNA polymerase_Homo sapiens_hsa030201.24975489
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22403383
33Rheumatoid arthritis_Homo sapiens_hsa053231.18818191
34Caffeine metabolism_Homo sapiens_hsa002321.15984128
35Non-homologous end-joining_Homo sapiens_hsa034501.15301560
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14560976
37Viral myocarditis_Homo sapiens_hsa054161.14038602
38Homologous recombination_Homo sapiens_hsa034401.13373899
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10951283
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09478091
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09100351
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.08423731
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07801729
44Hepatitis B_Homo sapiens_hsa051611.07184607
45Nucleotide excision repair_Homo sapiens_hsa034201.06204092
46Toxoplasmosis_Homo sapiens_hsa051451.05622619
47Pyrimidine metabolism_Homo sapiens_hsa002401.03545586
48Malaria_Homo sapiens_hsa051441.03240617
49Influenza A_Homo sapiens_hsa051641.03185144
50Phagosome_Homo sapiens_hsa041450.98565776
51Epstein-Barr virus infection_Homo sapiens_hsa051690.93195579
52Chemokine signaling pathway_Homo sapiens_hsa040620.92405101
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91571006
54TNF signaling pathway_Homo sapiens_hsa046680.87297264
55RNA degradation_Homo sapiens_hsa030180.84944396
56Apoptosis_Homo sapiens_hsa042100.82899357
57HTLV-I infection_Homo sapiens_hsa051660.80383628
58Proteasome_Homo sapiens_hsa030500.77306236
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76254592
60Legionellosis_Homo sapiens_hsa051340.75269066
61p53 signaling pathway_Homo sapiens_hsa041150.75161058
62Pertussis_Homo sapiens_hsa051330.74136547
63Pancreatic cancer_Homo sapiens_hsa052120.70313564
64Prolactin signaling pathway_Homo sapiens_hsa049170.68286872
65Chronic myeloid leukemia_Homo sapiens_hsa052200.67891743
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65855199
67Endocytosis_Homo sapiens_hsa041440.64713823
68Hepatitis C_Homo sapiens_hsa051600.64392233
69Salmonella infection_Homo sapiens_hsa051320.63431347
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62835077
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.62605817
72FoxO signaling pathway_Homo sapiens_hsa040680.62059560
73Regulation of autophagy_Homo sapiens_hsa041400.60592251
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.59705395
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59615172
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58509318
77Basal transcription factors_Homo sapiens_hsa030220.57933446
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57200994
79Other glycan degradation_Homo sapiens_hsa005110.57093612
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56738071
81Fanconi anemia pathway_Homo sapiens_hsa034600.56684477
82Colorectal cancer_Homo sapiens_hsa052100.56639394
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56473411
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56425062
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55620049
86Lysosome_Homo sapiens_hsa041420.54538497
87Viral carcinogenesis_Homo sapiens_hsa052030.54038575
88Cell cycle_Homo sapiens_hsa041100.53924702
89Tuberculosis_Homo sapiens_hsa051520.53789763
90Dorso-ventral axis formation_Homo sapiens_hsa043200.53002981
91N-Glycan biosynthesis_Homo sapiens_hsa005100.52625641
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51916672
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51747744
94Purine metabolism_Homo sapiens_hsa002300.49333435
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.48287761
96Choline metabolism in cancer_Homo sapiens_hsa052310.47363772
97Sulfur relay system_Homo sapiens_hsa041220.46861912
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46197858
99MAPK signaling pathway_Homo sapiens_hsa040100.45961052
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.45532283
101Non-small cell lung cancer_Homo sapiens_hsa052230.45378316
102VEGF signaling pathway_Homo sapiens_hsa043700.44995981
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44794933
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42897468
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42215078
106Renal cell carcinoma_Homo sapiens_hsa052110.41834568
107Type I diabetes mellitus_Homo sapiens_hsa049400.40628164
108African trypanosomiasis_Homo sapiens_hsa051430.38853775
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38210936
110Notch signaling pathway_Homo sapiens_hsa043300.37636417
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.37320615
112Insulin resistance_Homo sapiens_hsa049310.36769703
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35778063
114Inositol phosphate metabolism_Homo sapiens_hsa005620.35760976
115mTOR signaling pathway_Homo sapiens_hsa041500.33134470
116Ras signaling pathway_Homo sapiens_hsa040140.29815750
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29579993
118Endometrial cancer_Homo sapiens_hsa052130.29290135
119Rap1 signaling pathway_Homo sapiens_hsa040150.29210418
120GnRH signaling pathway_Homo sapiens_hsa049120.29178382
121Small cell lung cancer_Homo sapiens_hsa052220.26583510
122Selenocompound metabolism_Homo sapiens_hsa004500.25979158
123Staphylococcus aureus infection_Homo sapiens_hsa051500.25943928
124Pentose phosphate pathway_Homo sapiens_hsa000300.25646267
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25444040
126Renin secretion_Homo sapiens_hsa049240.25229001
127Arachidonic acid metabolism_Homo sapiens_hsa005900.24096190
128Protein export_Homo sapiens_hsa030600.23621769
129Type II diabetes mellitus_Homo sapiens_hsa049300.23405941
130ABC transporters_Homo sapiens_hsa020100.23369009
131Thyroid cancer_Homo sapiens_hsa052160.23331699
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23125932
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.22912841

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