GIMAP1-GIMAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring readthrough transcription between the neighboring GIMAP1 (GTPase, IMAP family member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on chromosome 7. Alternative splicing results in multiple readthrough transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.29463749
2negative regulation of cell killing (GO:0031342)7.29463749
3positive regulation of gamma-delta T cell activation (GO:0046645)6.94413991
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.85493482
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.39596767
6antigen processing and presentation of endogenous antigen (GO:0019883)6.10935041
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.83556908
8leukocyte aggregation (GO:0070486)5.26117367
9regulation of gamma-delta T cell activation (GO:0046643)5.17240000
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.13703492
11regulation of B cell receptor signaling pathway (GO:0050855)5.02530703
12regulation of gamma-delta T cell differentiation (GO:0045586)4.95927698
13negative thymic T cell selection (GO:0045060)4.78731734
14negative T cell selection (GO:0043383)4.75335709
15detection of other organism (GO:0098543)4.69711307
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.68356140
17modulation by symbiont of host immune response (GO:0052553)4.68356140
18positive regulation by symbiont of host defense response (GO:0052509)4.68356140
19modulation by symbiont of host defense response (GO:0052031)4.68356140
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.68356140
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.68356140
22detection of bacterium (GO:0016045)4.67848501
23response to interleukin-15 (GO:0070672)4.57918372
24regulation of T cell tolerance induction (GO:0002664)4.40262964
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.38782038
26T cell migration (GO:0072678)4.34726103
27neutrophil activation involved in immune response (GO:0002283)4.31296257
28cellular response to interleukin-15 (GO:0071350)4.26487643
29positive thymic T cell selection (GO:0045059)4.19255156
30negative regulation of interleukin-12 production (GO:0032695)4.11840860
31negative regulation of T cell mediated immunity (GO:0002710)4.08616346
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.08112610
33macrophage activation involved in immune response (GO:0002281)3.97872487
34thymic T cell selection (GO:0045061)3.97326286
35negative regulation of leukocyte mediated immunity (GO:0002704)3.95649414
36T cell selection (GO:0045058)3.95169087
37regulation of tolerance induction (GO:0002643)3.90991076
38cellular response to type I interferon (GO:0071357)3.83406929
39type I interferon signaling pathway (GO:0060337)3.83406929
40immunoglobulin mediated immune response (GO:0016064)3.81116742
41response to type I interferon (GO:0034340)3.80282821
42positive T cell selection (GO:0043368)3.79783277
43activated T cell proliferation (GO:0050798)3.72813992
44respiratory burst (GO:0045730)3.69491475
45regulation of natural killer cell mediated immunity (GO:0002715)3.66631076
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.66631076
47regulation of regulatory T cell differentiation (GO:0045589)3.64999479
48cellular extravasation (GO:0045123)3.64400968
49detection of external biotic stimulus (GO:0098581)3.63553154
50antigen processing and presentation via MHC class Ib (GO:0002475)3.63201928
51negative regulation of phagocytosis (GO:0050765)3.57356554
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.54906671
53tolerance induction (GO:0002507)3.54316332
54response to peptidoglycan (GO:0032494)3.54155958
55regulation of T cell mediated cytotoxicity (GO:0001914)3.52154571
56regulation of alpha-beta T cell proliferation (GO:0046640)3.50244560
57positive regulation of tolerance induction (GO:0002645)3.48924947
58regulation of B cell differentiation (GO:0045577)3.47279035
59negative regulation of erythrocyte differentiation (GO:0045647)3.46778853
60neutrophil activation (GO:0042119)3.38377600
61B cell receptor signaling pathway (GO:0050853)3.36956804
62regulation of interferon-beta biosynthetic process (GO:0045357)3.35800740
63positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34954561
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33712550
65positive regulation of B cell differentiation (GO:0045579)3.30271123
66myeloid cell activation involved in immune response (GO:0002275)3.26105027
67leukocyte migration involved in inflammatory response (GO:0002523)3.25661102
68regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23939852
69interferon-gamma-mediated signaling pathway (GO:0060333)3.21540246
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20998873
71granulocyte activation (GO:0036230)3.13837363
72negative regulation of innate immune response (GO:0045824)3.12942895
73detection of biotic stimulus (GO:0009595)3.12719593
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09110814
75response to host immune response (GO:0052572)3.09110814
76positive regulation of granulocyte differentiation (GO:0030854)3.07889829
77T cell homeostasis (GO:0043029)3.07795588
78regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07704854
79regulation of interleukin-2 biosynthetic process (GO:0045076)3.04853998
80myeloid dendritic cell differentiation (GO:0043011)3.01799617
81regulation of mast cell degranulation (GO:0043304)3.01085701
82production of molecular mediator involved in inflammatory response (GO:0002532)3.00555571
83leukocyte degranulation (GO:0043299)2.99688026
84B cell mediated immunity (GO:0019724)2.99422462
85myeloid dendritic cell activation (GO:0001773)2.98917709
86antigen receptor-mediated signaling pathway (GO:0050851)2.95602803
87interferon-gamma production (GO:0032609)2.95165723
88T cell receptor signaling pathway (GO:0050852)2.92893835
89negative regulation of type 2 immune response (GO:0002829)2.91989875
90response to muramyl dipeptide (GO:0032495)2.91147572
91negative regulation of cytokine production involved in immune response (GO:0002719)2.90921752
92response to host (GO:0075136)2.89167193
93response to host defenses (GO:0052200)2.89167193
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89167193
95microglial cell activation (GO:0001774)2.89154427
96dendritic cell chemotaxis (GO:0002407)2.88835141
97defense response to protozoan (GO:0042832)2.86962454
98negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86733969
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84865517
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84742737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.61641116
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.60216128
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.17726742
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.01595868
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.81463823
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46978605
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.24757023
8RUNX_20019798_ChIP-Seq_JUKART_Human3.07943077
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96852607
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90515478
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.82438789
12VDR_21846776_ChIP-Seq_THP-1_Human2.75187801
13MAF_26560356_Chip-Seq_TH1_Human2.72092869
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71467099
15MYB_26560356_Chip-Seq_TH2_Human2.64955711
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61418195
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55624213
18MYC_22102868_ChIP-Seq_BL_Human2.54867949
19SPI1_23547873_ChIP-Seq_NB4_Human2.52382870
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.50537062
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50110809
22UTX_26944678_Chip-Seq_JUKART_Human2.47900803
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46863344
24VDR_24763502_ChIP-Seq_THP-1_Human2.38318668
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.31158545
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28301167
27SPI1_23127762_ChIP-Seq_K562_Human2.27277164
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.26225184
29MYB_26560356_Chip-Seq_TH1_Human2.25711659
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18811408
31MAF_26560356_Chip-Seq_TH2_Human2.14842634
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13337646
33KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03360158
34TCF7_22412390_ChIP-Seq_EML_Mouse2.02392199
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01093696
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00639799
37SCL_19346495_ChIP-Seq_HPC-7_Human1.98712100
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92210617
39GATA3_27048872_Chip-Seq_THYMUS_Human1.87059760
40KDM2B_26808549_Chip-Seq_DND41_Human1.85447628
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80831772
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74293823
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74123128
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67030607
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64510326
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61788704
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58141365
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56020860
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.55960292
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.55049954
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51493495
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50135539
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47723292
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.44506300
55LXR_22292898_ChIP-Seq_THP-1_Human1.44340325
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41383830
57VDR_24787735_ChIP-Seq_THP-1_Human1.38228325
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36353493
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35937253
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.35847963
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34378360
62GATA3_26560356_Chip-Seq_TH2_Human1.33629626
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.33361451
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33111396
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32669563
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30485176
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26493562
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25538539
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25493184
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23806985
71BCL6_27268052_Chip-Seq_Bcells_Human1.22697392
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21441216
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21033233
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21004554
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20150059
76PU_27001747_Chip-Seq_BMDM_Mouse1.17475991
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17086572
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15794150
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15310408
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11281494
81BCOR_27268052_Chip-Seq_Bcells_Human1.11191340
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06523867
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04494605
84GATA1_19941826_ChIP-Seq_K562_Human1.01052204
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00951433
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00728813
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00073557
88CIITA_25753668_ChIP-Seq_RAJI_Human0.96191767
89SA1_27219007_Chip-Seq_ERYTHROID_Human0.95741269
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.92473606
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.91114719
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89844572
93NCOR1_26117541_ChIP-Seq_K562_Human0.88597247
94GATA1_22025678_ChIP-Seq_K562_Human0.88512627
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86396788
96SPI1_20517297_ChIP-Seq_HL60_Human0.85528155
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84495163
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83402981
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80850860
100P68_20966046_ChIP-Seq_HELA_Human0.79414143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.50584368
2MP0003436_decreased_susceptibility_to4.08632018
3MP0005671_abnormal_response_to3.78847598
4MP0001835_abnormal_antigen_presentation3.64442342
5MP0003763_abnormal_thymus_physiology3.44958731
6MP0003303_peritoneal_inflammation3.28778494
7MP0006082_CNS_inflammation3.24505292
8MP0001800_abnormal_humoral_immune3.14021111
9MP0005000_abnormal_immune_tolerance3.02111812
10MP0001790_abnormal_immune_system2.96253142
11MP0005387_immune_system_phenotype2.96253142
12MP0009785_altered_susceptibility_to2.96250953
13MP0002419_abnormal_innate_immunity2.94839266
14MP0005025_abnormal_response_to2.92123359
15MP0000685_abnormal_immune_system2.89635711
16MP0002723_abnormal_immune_serum2.70477256
17MP0002420_abnormal_adaptive_immunity2.69721961
18MP0001819_abnormal_immune_cell2.66378079
19MP0002452_abnormal_antigen_presenting2.60458376
20MP0003300_gastrointestinal_ulcer2.50644940
21MP0009333_abnormal_splenocyte_physiolog2.36078654
22MP0002148_abnormal_hypersensitivity_rea2.32135700
23MP0002405_respiratory_system_inflammati2.18287695
24MP0002398_abnormal_bone_marrow2.12820696
25MP0001533_abnormal_skeleton_physiology2.12468059
26MP0010155_abnormal_intestine_physiology2.09204747
27MP0000716_abnormal_immune_system2.05164977
28MP0003866_abnormal_defecation1.98906446
29MP0003191_abnormal_cellular_cholesterol1.98087402
30MP0000703_abnormal_thymus_morphology1.86343244
31MP0004947_skin_inflammation1.84554051
32MP0005464_abnormal_platelet_physiology1.79999151
33MP0000689_abnormal_spleen_morphology1.79270384
34MP0001845_abnormal_inflammatory_respons1.79191646
35MP0004510_myositis1.78801720
36MP0002722_abnormal_immune_system1.74952099
37MP0001873_stomach_inflammation1.73284758
38MP0000465_gastrointestinal_hemorrhage1.63556506
39MP0002429_abnormal_blood_cell1.60769722
40MP0003172_abnormal_lysosome_physiology1.56890829
41MP0003828_pulmonary_edema1.55609318
42MP0008260_abnormal_autophagy1.54022692
43MP0008469_abnormal_protein_level1.50218781
44MP0005310_abnormal_salivary_gland1.48460280
45MP0002132_abnormal_respiratory_system1.40376806
46MP0002396_abnormal_hematopoietic_system1.40288803
47MP0009278_abnormal_bone_marrow1.39652355
48MP0004381_abnormal_hair_follicle1.37383842
49MP0001851_eye_inflammation1.36023807
50MP0002998_abnormal_bone_remodeling1.30589709
51MP0000858_altered_metastatic_potential1.29560208
52MP0005058_abnormal_lysosome_morphology1.25512894
53MP0002933_joint_inflammation1.22115023
54MP0009764_decreased_sensitivity_to1.20715804
55MP0005451_abnormal_body_composition1.18522643
56MP0002277_abnormal_respiratory_mucosa1.17970312
57MP0002166_altered_tumor_susceptibility1.16227072
58MP0003690_abnormal_glial_cell1.15820789
59MP0003183_abnormal_peptide_metabolism1.12367496
60MP0004883_abnormal_blood_vessel1.11438431
61MP0000490_abnormal_crypts_of1.04524413
62MP0003448_altered_tumor_morphology0.97121912
63MP0001663_abnormal_digestive_system0.97120973
64MP0005166_decreased_susceptibility_to0.95948243
65MP0003075_altered_response_to0.95049730
66MP0005075_abnormal_melanosome_morpholog0.94167527
67MP0001853_heart_inflammation0.93115012
68MP0005397_hematopoietic_system_phenotyp0.92934919
69MP0001545_abnormal_hematopoietic_system0.92934919
70MP0002138_abnormal_hepatobiliary_system0.90687814
71MP0000604_amyloidosis0.87300490
72MP0000343_altered_response_to0.87048043
73MP0009763_increased_sensitivity_to0.85494343
74MP0004130_abnormal_muscle_cell0.83977046
75MP0005390_skeleton_phenotype0.82280899
76MP0005164_abnormal_response_to0.77722683
77MP0003045_fibrosis0.75542781
78MP0009840_abnormal_foam_cell0.74493146
79MP0004808_abnormal_hematopoietic_stem0.67725820
80MP0002006_tumorigenesis0.67286855
81MP0003795_abnormal_bone_structure0.66054211
82MP0001986_abnormal_taste_sensitivity0.64123395
83MP0009765_abnormal_xenobiotic_induced0.63407053
84MP0003806_abnormal_nucleotide_metabolis0.62073390
85MP0000249_abnormal_blood_vessel0.61742346
86MP0008004_abnormal_stomach_pH0.61692480
87MP0008874_decreased_physiological_sensi0.58392038
88MP0005381_digestive/alimentary_phenotyp0.54876398
89MP0002009_preneoplasia0.54554141
90MP0003091_abnormal_cell_migration0.53578263
91MP0002693_abnormal_pancreas_physiology0.53083695
92MP0002019_abnormal_tumor_incidence0.51550365
93MP0005167_abnormal_blood-brain_barrier0.48015308
94MP0009115_abnormal_fat_cell0.47398320
95MP0001348_abnormal_lacrimal_gland0.45997749
96MP0000015_abnormal_ear_pigmentation0.45435196
97MP0005319_abnormal_enzyme/_coenzyme0.45163748
98MP0000609_abnormal_liver_physiology0.44086443
99MP0000920_abnormal_myelination0.43877164
100MP0003221_abnormal_cardiomyocyte_apopto0.41610552

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.02784165
2Recurrent abscess formation (HP:0002722)5.56408252
3Myositis (HP:0100614)5.52718120
4Recurrent bacterial skin infections (HP:0005406)5.42244473
5Abnormality of macrophages (HP:0004311)5.22356191
6Stomatitis (HP:0010280)5.03548657
7Elevated erythrocyte sedimentation rate (HP:0003565)4.93606382
8Orchitis (HP:0100796)4.88473055
9Optic neuritis (HP:0100653)4.62086785
10Retrobulbar optic neuritis (HP:0100654)4.62086785
11Recurrent gram-negative bacterial infections (HP:0005420)4.54695259
12Recurrent fungal infections (HP:0002841)4.30657205
13T lymphocytopenia (HP:0005403)4.26032852
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.19265894
15Mediastinal lymphadenopathy (HP:0100721)3.99810735
16Meningitis (HP:0001287)3.98304349
17Obstructive lung disease (HP:0006536)3.97943728
18Chronic obstructive pulmonary disease (HP:0006510)3.97943728
19Abnormality of T cell number (HP:0011839)3.94190474
20Gastrointestinal infarctions (HP:0005244)3.93877656
21Spontaneous hematomas (HP:0007420)3.89934254
22Encephalitis (HP:0002383)3.75321386
23Recurrent skin infections (HP:0001581)3.69981526
24Increased IgE level (HP:0003212)3.67068337
25Recurrent cutaneous fungal infections (HP:0011370)3.53886720
26Chronic mucocutaneous candidiasis (HP:0002728)3.53886720
27Vasculitis (HP:0002633)3.49845394
28Panhypogammaglobulinemia (HP:0003139)3.47505225
29Pustule (HP:0200039)3.43224737
30Abnormality of T cells (HP:0002843)3.35719743
31Keratoconjunctivitis sicca (HP:0001097)3.34654321
32Recurrent viral infections (HP:0004429)3.31070006
33Gingivitis (HP:0000230)3.25760581
34Inflammation of the large intestine (HP:0002037)3.24455601
35Gastrointestinal inflammation (HP:0004386)3.16558191
36Prolonged bleeding time (HP:0003010)3.13715740
37Increased IgM level (HP:0003496)3.10187806
38Keratoconjunctivitis (HP:0001096)3.09155199
39Urticaria (HP:0001025)3.05850461
40Pulmonary infiltrates (HP:0002113)3.03752134
41Leukocytosis (HP:0001974)3.00028141
42Cellulitis (HP:0100658)2.99914002
43Chest pain (HP:0100749)2.98636123
44Lymphopenia (HP:0001888)2.91143064
45Hemoptysis (HP:0002105)2.86821777
46Hypochromic microcytic anemia (HP:0004840)2.86290012
47Granulocytopenia (HP:0001913)2.84071831
48Hypochromic anemia (HP:0001931)2.83418028
49IgM deficiency (HP:0002850)2.73847856
50Colitis (HP:0002583)2.73592900
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.69304020
52Abnormality of T cell physiology (HP:0011840)2.60801171
53Episodic fever (HP:0001954)2.56746493
54Epistaxis (HP:0000421)2.55908841
55Severe combined immunodeficiency (HP:0004430)2.54579977
56Pulmonary embolism (HP:0002204)2.54076383
57Petechiae (HP:0000967)2.51986905
58Hypergammaglobulinemia (HP:0010702)2.49945321
59Autoimmune hemolytic anemia (HP:0001890)2.46574882
60Gingival bleeding (HP:0000225)2.44305125
61Anorexia (HP:0002039)2.44205334
62Eosinophilia (HP:0001880)2.40404039
63Agammaglobulinemia (HP:0004432)2.37918934
64Recurrent bronchitis (HP:0002837)2.37088288
65Osteomyelitis (HP:0002754)2.36090710
66Arterial thrombosis (HP:0004420)2.34040624
67Microcytic anemia (HP:0001935)2.26678999
68Sepsis (HP:0100806)2.25953813
69Abnormality of eosinophils (HP:0001879)2.24620507
70Purpura (HP:0000979)2.24523687
71Abnormality of the pleura (HP:0002103)2.21323323
72Hematochezia (HP:0002573)2.19756780
73Hepatosplenomegaly (HP:0001433)2.19086314
74Combined immunodeficiency (HP:0005387)2.18200094
75Gastrointestinal stroma tumor (HP:0100723)2.15351570
76IgG deficiency (HP:0004315)2.14531698
77Chronic diarrhea (HP:0002028)2.13063804
78Premature loss of primary teeth (HP:0006323)2.09271782
79Verrucae (HP:0200043)2.09098156
80Papilloma (HP:0012740)2.09098156
81Abnormality of liposaccharide metabolism (HP:0010968)2.08916238
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.08916238
83Abnormality of glycolipid metabolism (HP:0010969)2.08916238
84Increased cerebral lipofuscin (HP:0011813)2.07896764
85Loss of speech (HP:0002371)2.05750697
86Autoimmune thrombocytopenia (HP:0001973)2.04908389
87Gangrene (HP:0100758)2.03445448
88Acne (HP:0001061)2.03035012
89Skin ulcer (HP:0200042)2.02013400
90Amyloidosis (HP:0011034)2.01338430
91Acute hepatic failure (HP:0006554)2.00509281
92Glomerulopathy (HP:0100820)1.99801733
93Joint swelling (HP:0001386)1.97437052
94Increased serum ferritin (HP:0003281)1.96574838
95Metaphyseal cupping (HP:0003021)1.93613896
96Chronic otitis media (HP:0000389)1.90539668
97Peritonitis (HP:0002586)1.90265704
98Papilledema (HP:0001085)1.88673236
99Restrictive lung disease (HP:0002091)1.88575126
100Recurrent sinusitis (HP:0011108)1.88101248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.53944857
2RIPK43.94907035
3FES3.13860686
4TYK23.00567951
5PRPF4B2.87383077
6CSK2.78115031
7BLK2.54826566
8ERN12.52885973
9TXK2.35467754
10ZAP702.34911796
11TNK22.33261006
12IRAK42.26616018
13MAP2K32.22147646
14GRK62.07843403
15JAK32.00701087
16BTK2.00199370
17EPHB11.82648922
18MAP3K131.81281589
19SYK1.77512454
20HCK1.73164224
21ITK1.68845876
22JAK11.67557503
23IKBKE1.66116184
24KIT1.58145832
25TESK21.57825954
26MAP3K111.56814751
27MAP3K141.55265974
28LCK1.49924669
29FGR1.47511122
30TBK11.44601011
31TEC1.43286230
32MAP3K31.43174969
33TAOK11.43107323
34SIK31.43026067
35LYN1.37537618
36FGFR41.33981363
37CSF1R1.31674800
38SIK21.24144109
39JAK21.20581359
40TAOK31.12834256
41MARK31.10136398
42TRIB31.08396596
43TGFBR21.05964763
44MAP3K11.04894615
45SMG10.99067312
46IKBKB0.96511721
47NLK0.95681922
48STK100.95609661
49MAP3K100.93670720
50CAMKK20.93389305
51CAMKK10.91267824
52KDR0.89819254
53FGFR30.88553273
54MARK20.85655721
55PASK0.85337211
56PTK60.84231775
57KSR20.83804758
58PDK10.81787745
59YES10.80782102
60PRKCQ0.78364797
61MAPK120.78192168
62TAOK20.77772335
63CDC42BPA0.75381298
64PRKD20.69985330
65FYN0.68662796
66MAP3K70.68015425
67CDK190.64828052
68LRRK20.61217486
69SIK10.60700155
70HIPK20.60204263
71MAPK70.59788482
72PDPK10.56211902
73EPHA30.55536621
74RET0.52904798
75GRK70.52609530
76TYRO30.50701277
77CDK40.47475013
78MAPK110.46335130
79PIM10.44967083
80DYRK1B0.43930627
81MATK0.42506184
82RPS6KL10.41758098
83RPS6KC10.41758098
84PRKCH0.40953085
85IRAK10.38628865
86STK110.37289672
87BMPR20.33680407
88RPS6KA60.33513074
89STK380.33356235
90MAP3K50.29129006
91TTN0.28897854
92MAPKAPK20.28583614
93MAP2K60.28253025
94PTK2B0.27136426
95CDK60.25590560
96SGK30.25336810
97PDGFRB0.25169268
98INSR0.24468828
99MAP2K20.24280565
100MAPK40.23349061

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.31887320
2Graft-versus-host disease_Homo sapiens_hsa053322.93749245
3Osteoclast differentiation_Homo sapiens_hsa043802.88558300
4Allograft rejection_Homo sapiens_hsa053302.82394448
5Autoimmune thyroid disease_Homo sapiens_hsa053202.68025652
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.66904448
7Leishmaniasis_Homo sapiens_hsa051402.63117956
8Staphylococcus aureus infection_Homo sapiens_hsa051502.47649098
9T cell receptor signaling pathway_Homo sapiens_hsa046602.26508515
10B cell receptor signaling pathway_Homo sapiens_hsa046622.19506862
11Antigen processing and presentation_Homo sapiens_hsa046122.14491511
12Type I diabetes mellitus_Homo sapiens_hsa049402.04981496
13Measles_Homo sapiens_hsa051622.02361208
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00245135
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91020064
16Hematopoietic cell lineage_Homo sapiens_hsa046401.90613702
17Viral myocarditis_Homo sapiens_hsa054161.87674343
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86545336
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.86412546
20Tuberculosis_Homo sapiens_hsa051521.84654454
21Acute myeloid leukemia_Homo sapiens_hsa052211.84027245
22Malaria_Homo sapiens_hsa051441.70227494
23Chemokine signaling pathway_Homo sapiens_hsa040621.65635064
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.60249075
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57363921
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57321109
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55768043
28Other glycan degradation_Homo sapiens_hsa005111.50455428
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48006359
30Herpes simplex infection_Homo sapiens_hsa051681.47469490
31Toxoplasmosis_Homo sapiens_hsa051451.44913967
32Influenza A_Homo sapiens_hsa051641.40134510
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.38722219
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33074219
35Asthma_Homo sapiens_hsa053101.29084110
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.23999178
37TNF signaling pathway_Homo sapiens_hsa046681.21164501
38Legionellosis_Homo sapiens_hsa051341.17040806
39Non-small cell lung cancer_Homo sapiens_hsa052231.15642825
40Hepatitis B_Homo sapiens_hsa051611.14853438
41Phagosome_Homo sapiens_hsa041451.14718795
42Rheumatoid arthritis_Homo sapiens_hsa053231.10639922
43Hepatitis C_Homo sapiens_hsa051601.10437884
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06317174
45Platelet activation_Homo sapiens_hsa046111.01773344
46Pertussis_Homo sapiens_hsa051331.01236545
47Shigellosis_Homo sapiens_hsa051311.01132761
48Pancreatic cancer_Homo sapiens_hsa052121.00844837
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99414569
50African trypanosomiasis_Homo sapiens_hsa051430.97720821
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95450895
52VEGF signaling pathway_Homo sapiens_hsa043700.92197294
53Chronic myeloid leukemia_Homo sapiens_hsa052200.91890016
54Apoptosis_Homo sapiens_hsa042100.88042340
55Salmonella infection_Homo sapiens_hsa051320.86307674
56Lysosome_Homo sapiens_hsa041420.79808459
57Endocytosis_Homo sapiens_hsa041440.78014763
58Epstein-Barr virus infection_Homo sapiens_hsa051690.77710554
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75734991
60Prolactin signaling pathway_Homo sapiens_hsa049170.74249474
61Renal cell carcinoma_Homo sapiens_hsa052110.73918819
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71918031
63HTLV-I infection_Homo sapiens_hsa051660.71260421
64Colorectal cancer_Homo sapiens_hsa052100.68346583
65Viral carcinogenesis_Homo sapiens_hsa052030.68024810
66FoxO signaling pathway_Homo sapiens_hsa040680.67005534
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.66952358
68Notch signaling pathway_Homo sapiens_hsa043300.66235736
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.65748635
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.63849158
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63814358
72Endometrial cancer_Homo sapiens_hsa052130.62685277
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62439272
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.60402594
75Choline metabolism in cancer_Homo sapiens_hsa052310.58264845
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57518829
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53738836
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51378616
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49172029
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48777231
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.48006076
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47093182
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46272687
84HIF-1 signaling pathway_Homo sapiens_hsa040660.45226338
85MAPK signaling pathway_Homo sapiens_hsa040100.44024727
86GnRH signaling pathway_Homo sapiens_hsa049120.43763804
87Inositol phosphate metabolism_Homo sapiens_hsa005620.43616136
88mTOR signaling pathway_Homo sapiens_hsa041500.43133269
89Insulin resistance_Homo sapiens_hsa049310.42581604
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.40761719
91Rap1 signaling pathway_Homo sapiens_hsa040150.40554223
92Amoebiasis_Homo sapiens_hsa051460.39664241
93Dorso-ventral axis formation_Homo sapiens_hsa043200.33152333
94Type II diabetes mellitus_Homo sapiens_hsa049300.33140455
95Long-term potentiation_Homo sapiens_hsa047200.32849570
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32553114
97Regulation of autophagy_Homo sapiens_hsa041400.32021140
98Prostate cancer_Homo sapiens_hsa052150.31103592
99Ras signaling pathway_Homo sapiens_hsa040140.29429133
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28811102

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