Rank | Gene Set | Z-score |
---|---|---|
1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.23620249 |
2 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.12599493 |
3 | negative regulation of cell killing (GO:0031342) | 6.12599493 |
4 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.99513065 |
5 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.75922179 |
6 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.19924469 |
7 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.12910954 |
8 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.08309042 |
9 | negative T cell selection (GO:0043383) | 4.82496816 |
10 | regulation of gamma-delta T cell activation (GO:0046643) | 4.78014372 |
11 | negative thymic T cell selection (GO:0045060) | 4.72856159 |
12 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.68673821 |
13 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.67280265 |
14 | cellular response to interleukin-15 (GO:0071350) | 4.52763086 |
15 | positive thymic T cell selection (GO:0045059) | 4.45523187 |
16 | response to interleukin-15 (GO:0070672) | 4.42049203 |
17 | T cell migration (GO:0072678) | 4.25628192 |
18 | activated T cell proliferation (GO:0050798) | 4.19933069 |
19 | positive T cell selection (GO:0043368) | 4.19680639 |
20 | negative regulation of T cell mediated immunity (GO:0002710) | 4.10311386 |
21 | leukocyte aggregation (GO:0070486) | 4.02887583 |
22 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.96023807 |
23 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.96023807 |
24 | modulation by symbiont of host immune response (GO:0052553) | 3.96023807 |
25 | positive regulation by symbiont of host defense response (GO:0052509) | 3.96023807 |
26 | modulation by symbiont of host defense response (GO:0052031) | 3.96023807 |
27 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.96023807 |
28 | regulation of regulatory T cell differentiation (GO:0045589) | 3.93147229 |
29 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.92486820 |
30 | neutrophil activation involved in immune response (GO:0002283) | 3.92314125 |
31 | T cell selection (GO:0045058) | 3.84001392 |
32 | immunoglobulin mediated immune response (GO:0016064) | 3.81340501 |
33 | regulation of T cell tolerance induction (GO:0002664) | 3.77552195 |
34 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.74965734 |
35 | detection of other organism (GO:0098543) | 3.73327347 |
36 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.73074360 |
37 | positive regulation of B cell differentiation (GO:0045579) | 3.72394063 |
38 | regulation of B cell differentiation (GO:0045577) | 3.71473211 |
39 | tolerance induction (GO:0002507) | 3.69437623 |
40 | thymic T cell selection (GO:0045061) | 3.69420195 |
41 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.68029968 |
42 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.65681111 |
43 | negative regulation of interleukin-12 production (GO:0032695) | 3.63167928 |
44 | mast cell activation (GO:0045576) | 3.62363886 |
45 | detection of bacterium (GO:0016045) | 3.61978951 |
46 | regulation of tolerance induction (GO:0002643) | 3.59433290 |
47 | cellular extravasation (GO:0045123) | 3.54432966 |
48 | B cell receptor signaling pathway (GO:0050853) | 3.53965543 |
49 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.52169425 |
50 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.52169425 |
51 | positive regulation of tolerance induction (GO:0002645) | 3.50480362 |
52 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.49638386 |
53 | interferon-gamma production (GO:0032609) | 3.48569995 |
54 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.47902796 |
55 | positive regulation of granulocyte differentiation (GO:0030854) | 3.47394533 |
56 | cellular response to type I interferon (GO:0071357) | 3.42707831 |
57 | type I interferon signaling pathway (GO:0060337) | 3.42707831 |
58 | microglial cell activation (GO:0001774) | 3.42388146 |
59 | response to type I interferon (GO:0034340) | 3.42352565 |
60 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.41982960 |
61 | macrophage activation involved in immune response (GO:0002281) | 3.40276651 |
62 | neutrophil activation (GO:0042119) | 3.39811107 |
63 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.33615499 |
64 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.33169245 |
65 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.30598713 |
66 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.28177823 |
67 | myeloid cell activation involved in immune response (GO:0002275) | 3.20707362 |
68 | T cell receptor signaling pathway (GO:0050852) | 3.20080192 |
69 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.19923088 |
70 | response to host immune response (GO:0052572) | 3.18930845 |
71 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.18930845 |
72 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.14116245 |
73 | respiratory burst (GO:0045730) | 3.11975821 |
74 | positive regulation of antigen processing and presentation (GO:0002579) | 3.10780970 |
75 | regulation of antigen processing and presentation (GO:0002577) | 3.09750688 |
76 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.08840147 |
77 | granulocyte activation (GO:0036230) | 3.06610497 |
78 | detection of external biotic stimulus (GO:0098581) | 3.06553634 |
79 | negative regulation of innate immune response (GO:0045824) | 3.06277684 |
80 | regulation of cell killing (GO:0031341) | 3.04877376 |
81 | B cell mediated immunity (GO:0019724) | 3.04660849 |
82 | leukocyte degranulation (GO:0043299) | 3.03562222 |
83 | response to peptidoglycan (GO:0032494) | 3.01968371 |
84 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.99746454 |
85 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.99552293 |
86 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.97569979 |
87 | dendritic cell chemotaxis (GO:0002407) | 2.91125398 |
88 | positive regulation of cell killing (GO:0031343) | 2.89775718 |
89 | dendritic cell migration (GO:0036336) | 2.88897512 |
90 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.86159118 |
91 | response to host (GO:0075136) | 2.86159118 |
92 | response to host defenses (GO:0052200) | 2.86159118 |
93 | T cell costimulation (GO:0031295) | 2.85719361 |
94 | cytidine deamination (GO:0009972) | 2.85311711 |
95 | cytidine metabolic process (GO:0046087) | 2.85311711 |
96 | cytidine catabolic process (GO:0006216) | 2.85311711 |
97 | detection of biotic stimulus (GO:0009595) | 2.85197701 |
98 | defense response to protozoan (GO:0042832) | 2.84873541 |
99 | regulation of alpha-beta T cell activation (GO:0046634) | 2.84795562 |
100 | regulation of T cell mediated immunity (GO:0002709) | 2.84292949 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.92361900 |
2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.37188922 |
3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.69481602 |
4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.22502258 |
5 | * IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.21006995 |
6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.19665849 |
7 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 3.47219887 |
8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.45901956 |
9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.16421934 |
10 | * MYB_26560356_Chip-Seq_TH2_Human | 2.96207597 |
11 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.89081267 |
12 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.78923875 |
13 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.57838797 |
14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.47485102 |
15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.43621111 |
16 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.39719900 |
17 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.36895945 |
18 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.34930956 |
19 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.30531482 |
20 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.27955405 |
21 | MYB_26560356_Chip-Seq_TH1_Human | 2.27142004 |
22 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.21000584 |
23 | * MAF_26560356_Chip-Seq_TH1_Human | 2.07556115 |
24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.06310684 |
25 | GATA3_26560356_Chip-Seq_TH2_Human | 2.02387601 |
26 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.95335251 |
27 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.93321790 |
28 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.89403786 |
29 | UTX_26944678_Chip-Seq_JUKART_Human | 1.86816934 |
30 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.86592847 |
31 | SPI1_23127762_ChIP-Seq_K562_Human | 1.82148890 |
32 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.72331363 |
33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.63943330 |
34 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.62778512 |
35 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.61984781 |
36 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61642500 |
37 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.58877108 |
38 | GATA1_22025678_ChIP-Seq_K562_Human | 1.53593995 |
39 | * NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.52640271 |
40 | MAF_26560356_Chip-Seq_TH2_Human | 1.52565732 |
41 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.52496476 |
42 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.42033735 |
43 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.41525585 |
44 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38118044 |
45 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.35815634 |
46 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.35744163 |
47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.32917967 |
48 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.31791772 |
49 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.30898151 |
50 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.29238373 |
51 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.22621108 |
52 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.17588370 |
53 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.14552011 |
54 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.13667085 |
55 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.10479389 |
56 | MYC_22102868_ChIP-Seq_BL_Human | 1.07935935 |
57 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.06419086 |
58 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.05504660 |
59 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.03287864 |
60 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.02669326 |
61 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.02650702 |
62 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.01346170 |
63 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.00701248 |
64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.97816442 |
65 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.96896393 |
66 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.96432083 |
67 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.95309644 |
68 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.94526388 |
69 | * GATA3_26560356_Chip-Seq_TH1_Human | 0.93152605 |
70 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.88915125 |
71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.88604298 |
72 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87113615 |
73 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.86970461 |
74 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.86476014 |
75 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.85210735 |
76 | * RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84566284 |
77 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.83133695 |
78 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82593547 |
79 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.82274589 |
80 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.80563080 |
81 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.80388725 |
82 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.79975600 |
83 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.79399003 |
84 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.77908779 |
85 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.77830936 |
86 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.77593665 |
87 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.77450790 |
88 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.77059563 |
89 | GATA1_19941826_ChIP-Seq_K562_Human | 0.76613024 |
90 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.76010999 |
91 | * P300_27268052_Chip-Seq_Bcells_Human | 0.74346024 |
92 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.74101583 |
93 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.72773856 |
94 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.69989658 |
95 | VDR_22108803_ChIP-Seq_LS180_Human | 0.69216604 |
96 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.68516711 |
97 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.68412585 |
98 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.68126347 |
99 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.67213199 |
100 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.66345363 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003724_increased_susceptibility_to | 4.75986801 |
2 | MP0001835_abnormal_antigen_presentation | 4.24616040 |
3 | MP0005671_abnormal_response_to | 4.19530811 |
4 | MP0003436_decreased_susceptibility_to | 3.45171378 |
5 | MP0001800_abnormal_humoral_immune | 3.37043493 |
6 | MP0003763_abnormal_thymus_physiology | 3.28264507 |
7 | MP0005000_abnormal_immune_tolerance | 3.19567353 |
8 | MP0009785_altered_susceptibility_to | 3.12394054 |
9 | MP0000685_abnormal_immune_system | 2.98795906 |
10 | MP0002723_abnormal_immune_serum | 2.87895487 |
11 | MP0005387_immune_system_phenotype | 2.83686509 |
12 | MP0001790_abnormal_immune_system | 2.83686509 |
13 | MP0006082_CNS_inflammation | 2.83609828 |
14 | MP0005025_abnormal_response_to | 2.80085370 |
15 | MP0002419_abnormal_innate_immunity | 2.71559438 |
16 | MP0002420_abnormal_adaptive_immunity | 2.71387689 |
17 | MP0002452_abnormal_antigen_presenting | 2.69732885 |
18 | MP0002148_abnormal_hypersensitivity_rea | 2.68457144 |
19 | MP0001819_abnormal_immune_cell | 2.68229763 |
20 | MP0003303_peritoneal_inflammation | 2.42128027 |
21 | MP0002398_abnormal_bone_marrow | 2.14503931 |
22 | MP0002405_respiratory_system_inflammati | 2.13528617 |
23 | MP0000716_abnormal_immune_system | 2.12896307 |
24 | MP0010155_abnormal_intestine_physiology | 2.01878681 |
25 | MP0009333_abnormal_splenocyte_physiolog | 2.00440881 |
26 | MP0005464_abnormal_platelet_physiology | 1.95029733 |
27 | MP0003866_abnormal_defecation | 1.93040067 |
28 | MP0000689_abnormal_spleen_morphology | 1.89668429 |
29 | MP0001845_abnormal_inflammatory_respons | 1.84617739 |
30 | MP0002166_altered_tumor_susceptibility | 1.82040281 |
31 | MP0001533_abnormal_skeleton_physiology | 1.77953785 |
32 | MP0002722_abnormal_immune_system | 1.74202892 |
33 | MP0000703_abnormal_thymus_morphology | 1.72034392 |
34 | MP0000465_gastrointestinal_hemorrhage | 1.70752511 |
35 | MP0003300_gastrointestinal_ulcer | 1.63391543 |
36 | MP0002429_abnormal_blood_cell | 1.63204999 |
37 | MP0004947_skin_inflammation | 1.55711501 |
38 | MP0001873_stomach_inflammation | 1.51367593 |
39 | MP0009764_decreased_sensitivity_to | 1.50340043 |
40 | MP0008469_abnormal_protein_level | 1.44373012 |
41 | MP0002138_abnormal_hepatobiliary_system | 1.41157043 |
42 | MP0004381_abnormal_hair_follicle | 1.39830004 |
43 | MP0002277_abnormal_respiratory_mucosa | 1.37246814 |
44 | MP0005310_abnormal_salivary_gland | 1.33596250 |
45 | MP0005075_abnormal_melanosome_morpholog | 1.33079614 |
46 | MP0002933_joint_inflammation | 1.24679460 |
47 | MP0002396_abnormal_hematopoietic_system | 1.22064510 |
48 | MP0002006_tumorigenesis | 1.21272774 |
49 | MP0003172_abnormal_lysosome_physiology | 1.18919055 |
50 | MP0003787_abnormal_imprinting | 1.16715569 |
51 | MP0001986_abnormal_taste_sensitivity | 1.11599744 |
52 | MP0003183_abnormal_peptide_metabolism | 1.11522091 |
53 | MP0002009_preneoplasia | 1.10614169 |
54 | MP0003191_abnormal_cellular_cholesterol | 1.09310339 |
55 | MP0003828_pulmonary_edema | 1.08548761 |
56 | MP0009278_abnormal_bone_marrow | 1.08164263 |
57 | MP0001851_eye_inflammation | 1.08117053 |
58 | MP0002132_abnormal_respiratory_system | 1.07240947 |
59 | MP0002998_abnormal_bone_remodeling | 1.00758585 |
60 | MP0000858_altered_metastatic_potential | 0.96554855 |
61 | MP0004883_abnormal_blood_vessel | 0.94214453 |
62 | MP0009763_increased_sensitivity_to | 0.91959723 |
63 | MP0001545_abnormal_hematopoietic_system | 0.89468888 |
64 | MP0005397_hematopoietic_system_phenotyp | 0.89468888 |
65 | MP0001663_abnormal_digestive_system | 0.87848643 |
66 | MP0001853_heart_inflammation | 0.86269971 |
67 | MP0000569_abnormal_digit_pigmentation | 0.85404869 |
68 | MP0005166_decreased_susceptibility_to | 0.80951233 |
69 | MP0004130_abnormal_muscle_cell | 0.75460111 |
70 | MP0003448_altered_tumor_morphology | 0.75143357 |
71 | MP0003690_abnormal_glial_cell | 0.72609512 |
72 | MP0004808_abnormal_hematopoietic_stem | 0.72564335 |
73 | MP0008877_abnormal_DNA_methylation | 0.72512804 |
74 | MP0009765_abnormal_xenobiotic_induced | 0.72062499 |
75 | MP0008260_abnormal_autophagy | 0.71447821 |
76 | MP0002693_abnormal_pancreas_physiology | 0.70860824 |
77 | MP0000015_abnormal_ear_pigmentation | 0.68880347 |
78 | MP0005390_skeleton_phenotype | 0.67647738 |
79 | MP0003075_altered_response_to | 0.66499438 |
80 | MP0000343_altered_response_to | 0.65386134 |
81 | MP0003806_abnormal_nucleotide_metabolis | 0.64938003 |
82 | MP0000249_abnormal_blood_vessel | 0.62703307 |
83 | MP0003252_abnormal_bile_duct | 0.61534762 |
84 | MP0005164_abnormal_response_to | 0.60318186 |
85 | MP0002019_abnormal_tumor_incidence | 0.58886007 |
86 | MP0004484_altered_response_of | 0.55197782 |
87 | MP0005084_abnormal_gallbladder_morpholo | 0.55148472 |
88 | MP0003195_calcinosis | 0.54471577 |
89 | MP0002163_abnormal_gland_morphology | 0.53406859 |
90 | MP0005174_abnormal_tail_pigmentation | 0.53235077 |
91 | MP0003795_abnormal_bone_structure | 0.51527767 |
92 | MP0001765_abnormal_ion_homeostasis | 0.50902327 |
93 | MP0003045_fibrosis | 0.50720149 |
94 | MP0000604_amyloidosis | 0.49753408 |
95 | MP0000490_abnormal_crypts_of | 0.49693568 |
96 | MP0000372_irregular_coat_pigmentation | 0.49655056 |
97 | MP0002928_abnormal_bile_duct | 0.49325033 |
98 | MP0005085_abnormal_gallbladder_physiolo | 0.48975723 |
99 | MP0002136_abnormal_kidney_physiology | 0.48920675 |
100 | MP0008873_increased_physiological_sensi | 0.47253742 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.40961718 |
2 | T lymphocytopenia (HP:0005403) | 5.35051196 |
3 | Stomatitis (HP:0010280) | 5.33576029 |
4 | Abnormality of T cell number (HP:0011839) | 5.16492245 |
5 | Recurrent abscess formation (HP:0002722) | 5.05551296 |
6 | Myositis (HP:0100614) | 5.00618367 |
7 | Recurrent bacterial skin infections (HP:0005406) | 4.93966427 |
8 | Eczematoid dermatitis (HP:0000976) | 4.91574304 |
9 | Retrobulbar optic neuritis (HP:0100654) | 4.56342163 |
10 | Optic neuritis (HP:0100653) | 4.56342163 |
11 | Orchitis (HP:0100796) | 4.38602347 |
12 | Recurrent fungal infections (HP:0002841) | 4.31554377 |
13 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.27043872 |
14 | Gastrointestinal infarctions (HP:0005244) | 4.17678567 |
15 | Abnormality of T cells (HP:0002843) | 4.03276600 |
16 | Encephalitis (HP:0002383) | 3.99786132 |
17 | Panhypogammaglobulinemia (HP:0003139) | 3.98268579 |
18 | Abnormality of macrophages (HP:0004311) | 3.95799622 |
19 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.94700768 |
20 | Recurrent cutaneous fungal infections (HP:0011370) | 3.94700768 |
21 | Meningitis (HP:0001287) | 3.90528316 |
22 | Mediastinal lymphadenopathy (HP:0100721) | 3.78127011 |
23 | Recurrent skin infections (HP:0001581) | 3.65462196 |
24 | Vasculitis (HP:0002633) | 3.63526834 |
25 | Severe combined immunodeficiency (HP:0004430) | 3.56132037 |
26 | Leukocytosis (HP:0001974) | 3.55032659 |
27 | Spontaneous hematomas (HP:0007420) | 3.52355998 |
28 | Obstructive lung disease (HP:0006536) | 3.49184617 |
29 | Chronic obstructive pulmonary disease (HP:0006510) | 3.49184617 |
30 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.45518160 |
31 | IgG deficiency (HP:0004315) | 3.35996155 |
32 | Pulmonary infiltrates (HP:0002113) | 3.34417149 |
33 | Recurrent viral infections (HP:0004429) | 3.33225846 |
34 | Pustule (HP:0200039) | 3.30950087 |
35 | Keratoconjunctivitis sicca (HP:0001097) | 3.29688625 |
36 | Hemoptysis (HP:0002105) | 3.25560600 |
37 | Autoimmune hemolytic anemia (HP:0001890) | 3.23759598 |
38 | Keratoconjunctivitis (HP:0001096) | 3.23650984 |
39 | Abnormality of eosinophils (HP:0001879) | 3.22585806 |
40 | Recurrent bronchitis (HP:0002837) | 3.09685732 |
41 | Chest pain (HP:0100749) | 3.08299157 |
42 | Eosinophilia (HP:0001880) | 3.05458730 |
43 | Increased IgM level (HP:0003496) | 3.05200192 |
44 | Granulocytopenia (HP:0001913) | 3.04015604 |
45 | Abnormality of the prostate (HP:0008775) | 2.92197327 |
46 | Agammaglobulinemia (HP:0004432) | 2.91406982 |
47 | Abnormality of B cell number (HP:0010975) | 2.86516708 |
48 | Pulmonary embolism (HP:0002204) | 2.84758264 |
49 | Abnormality of T cell physiology (HP:0011840) | 2.84585928 |
50 | Prolonged bleeding time (HP:0003010) | 2.78327066 |
51 | Urticaria (HP:0001025) | 2.74646081 |
52 | Combined immunodeficiency (HP:0005387) | 2.73573915 |
53 | Papilledema (HP:0001085) | 2.72304530 |
54 | Inflammation of the large intestine (HP:0002037) | 2.69404092 |
55 | Arterial thrombosis (HP:0004420) | 2.67842682 |
56 | Chronic otitis media (HP:0000389) | 2.66426248 |
57 | Thyroiditis (HP:0100646) | 2.62966483 |
58 | Stomach cancer (HP:0012126) | 2.62416652 |
59 | Epistaxis (HP:0000421) | 2.59272123 |
60 | Chronic diarrhea (HP:0002028) | 2.58704934 |
61 | Lymphopenia (HP:0001888) | 2.56402743 |
62 | Gangrene (HP:0100758) | 2.52600777 |
63 | Anorexia (HP:0002039) | 2.51770389 |
64 | Autoimmune thrombocytopenia (HP:0001973) | 2.51220563 |
65 | Joint swelling (HP:0001386) | 2.49040714 |
66 | Gastrointestinal inflammation (HP:0004386) | 2.47558036 |
67 | B lymphocytopenia (HP:0010976) | 2.44242841 |
68 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.43873420 |
69 | Hypochromic anemia (HP:0001931) | 2.43007788 |
70 | Abnormality of the pleura (HP:0002103) | 2.42064608 |
71 | Gingivitis (HP:0000230) | 2.40740420 |
72 | Increased IgE level (HP:0003212) | 2.39841627 |
73 | Gingival bleeding (HP:0000225) | 2.33933514 |
74 | IgM deficiency (HP:0002850) | 2.33857064 |
75 | Episodic fever (HP:0001954) | 2.17771160 |
76 | Colitis (HP:0002583) | 2.17299221 |
77 | Hypoproteinemia (HP:0003075) | 2.15277564 |
78 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.15182427 |
79 | Hypergammaglobulinemia (HP:0010702) | 2.12944148 |
80 | Microcytic anemia (HP:0001935) | 2.12443544 |
81 | Hypochromic microcytic anemia (HP:0004840) | 2.10545815 |
82 | Glomerulopathy (HP:0100820) | 2.02339426 |
83 | Acute hepatic failure (HP:0006554) | 2.01166045 |
84 | Polyneuropathy (HP:0001271) | 2.00431997 |
85 | Hypoplasia of the thymus (HP:0000778) | 2.00099284 |
86 | Cellulitis (HP:0100658) | 1.99731122 |
87 | Vertigo (HP:0002321) | 1.99297982 |
88 | Keratitis (HP:0000491) | 1.99259123 |
89 | Sepsis (HP:0100806) | 1.99182414 |
90 | Alveolar cell carcinoma (HP:0006519) | 1.96867064 |
91 | Bronchitis (HP:0012387) | 1.95878278 |
92 | Verrucae (HP:0200043) | 1.95552133 |
93 | Papilloma (HP:0012740) | 1.95552133 |
94 | Recurrent sinusitis (HP:0011108) | 1.95349118 |
95 | Hemiplegia (HP:0002301) | 1.91995494 |
96 | Skin rash (HP:0000988) | 1.91721289 |
97 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.87657362 |
98 | Amaurosis fugax (HP:0100576) | 1.85944701 |
99 | Abnormality of iron homeostasis (HP:0011031) | 1.85326056 |
100 | Osteomyelitis (HP:0002754) | 1.84608678 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP4K1 | 4.44316503 |
2 | TXK | 4.20908592 |
3 | RIPK4 | 3.93129733 |
4 | TAOK3 | 3.60284900 |
5 | FES | 3.08539023 |
6 | GRK6 | 2.44228725 |
7 | TYK2 | 2.42337429 |
8 | BLK | 2.34327243 |
9 | BTK | 2.31069598 |
10 | CSK | 2.29992475 |
11 | SYK | 2.29820425 |
12 | IKBKE | 2.23757781 |
13 | ITK | 2.17150498 |
14 | TEC | 2.09001948 |
15 | KIT | 2.07289228 |
16 | JAK3 | 2.00484811 |
17 | TNK2 | 1.99443714 |
18 | ZAP70 | 1.98823476 |
19 | MAP3K14 | 1.94599168 |
20 | IRAK4 | 1.92311248 |
21 | JAK1 | 1.84656474 |
22 | LCK | 1.66417689 |
23 | LYN | 1.61005633 |
24 | CAMKK2 | 1.58302727 |
25 | HCK | 1.57045095 |
26 | BMPR2 | 1.47947550 |
27 | IKBKB | 1.46050907 |
28 | TBK1 | 1.42390804 |
29 | CSF1R | 1.40285163 |
30 | TLK1 | 1.36782311 |
31 | MAP2K3 | 1.32803213 |
32 | PRKCQ | 1.22511173 |
33 | JAK2 | 1.12890881 |
34 | MARK3 | 1.09828221 |
35 | ADRBK2 | 1.07850912 |
36 | FRK | 1.05143193 |
37 | MATK | 1.00596625 |
38 | GRK7 | 0.94633746 |
39 | PRPF4B | 0.92973613 |
40 | NLK | 0.91210173 |
41 | CAMKK1 | 0.90485276 |
42 | MAP3K11 | 0.90465496 |
43 | FGR | 0.90419153 |
44 | PIK3CG | 0.87149267 |
45 | SIK2 | 0.85750339 |
46 | PASK | 0.83659165 |
47 | CDK19 | 0.83263033 |
48 | MAP3K13 | 0.81067578 |
49 | PIM1 | 0.78980529 |
50 | KDR | 0.75431350 |
51 | MAP2K2 | 0.74544595 |
52 | NUAK1 | 0.73865744 |
53 | TESK2 | 0.70718259 |
54 | FGFR3 | 0.69836796 |
55 | EPHB1 | 0.64637167 |
56 | PDK1 | 0.64502965 |
57 | IRAK1 | 0.62981415 |
58 | FYN | 0.62905325 |
59 | SIK3 | 0.62367733 |
60 | TGFBR2 | 0.59116480 |
61 | MAP3K1 | 0.57290186 |
62 | MAP2K6 | 0.57062558 |
63 | MUSK | 0.57023290 |
64 | ERN1 | 0.54517301 |
65 | HIPK2 | 0.53465781 |
66 | MAPK7 | 0.52604877 |
67 | PINK1 | 0.49857880 |
68 | RPS6KA6 | 0.49837955 |
69 | MAP3K3 | 0.49365661 |
70 | PRKCH | 0.47779516 |
71 | STK10 | 0.45916473 |
72 | STK11 | 0.45801025 |
73 | ZAK | 0.44168318 |
74 | ACVR1B | 0.44131507 |
75 | ABL1 | 0.44002017 |
76 | DAPK2 | 0.43553174 |
77 | MAP3K7 | 0.41482950 |
78 | MAP3K6 | 0.40953249 |
79 | MAP3K5 | 0.39938049 |
80 | RPS6KL1 | 0.39779036 |
81 | RPS6KC1 | 0.39779036 |
82 | TAOK1 | 0.39716965 |
83 | MAPK12 | 0.38627277 |
84 | YES1 | 0.37897329 |
85 | MAP4K2 | 0.37507253 |
86 | CDK4 | 0.35423350 |
87 | BCKDK | 0.34598091 |
88 | MARK2 | 0.34568659 |
89 | TYRO3 | 0.32491235 |
90 | FGFR4 | 0.32452718 |
91 | EPHA3 | 0.32415015 |
92 | LRRK2 | 0.31961651 |
93 | PRKCD | 0.31455353 |
94 | ADRBK1 | 0.31443955 |
95 | MAPK11 | 0.31271828 |
96 | PTK2B | 0.31125492 |
97 | CHUK | 0.31110576 |
98 | IGF1R | 0.31086537 |
99 | OXSR1 | 0.29203835 |
100 | MAPK4 | 0.28823030 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.00052410 |
2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.51060004 |
3 | Allograft rejection_Homo sapiens_hsa05330 | 3.41674534 |
4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.24569908 |
5 | Leishmaniasis_Homo sapiens_hsa05140 | 2.69770877 |
6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.65293171 |
7 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.61539652 |
8 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.59676178 |
9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.56917664 |
10 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.55341271 |
11 | Asthma_Homo sapiens_hsa05310 | 2.42253683 |
12 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.35192848 |
13 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.31043853 |
14 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.28867774 |
15 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.20436340 |
16 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.03433076 |
17 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.97220010 |
18 | Measles_Homo sapiens_hsa05162 | 1.95662047 |
19 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.94455638 |
20 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.80011963 |
21 | Viral myocarditis_Homo sapiens_hsa05416 | 1.70968334 |
22 | Tuberculosis_Homo sapiens_hsa05152 | 1.68461610 |
23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.68225121 |
24 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.64885558 |
25 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.55627673 |
26 | Malaria_Homo sapiens_hsa05144 | 1.53565397 |
27 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.50628688 |
28 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.49585909 |
29 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.40654198 |
30 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.38001808 |
31 | Influenza A_Homo sapiens_hsa05164 | 1.35221894 |
32 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.34824242 |
33 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.32608076 |
34 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.28731338 |
35 | Legionellosis_Homo sapiens_hsa05134 | 1.15767782 |
36 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.15500474 |
37 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.13819171 |
38 | Platelet activation_Homo sapiens_hsa04611 | 1.08969421 |
39 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.08634213 |
40 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.93826682 |
41 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.91166231 |
42 | Phagosome_Homo sapiens_hsa04145 | 0.91035486 |
43 | Pertussis_Homo sapiens_hsa05133 | 0.88742311 |
44 | Hepatitis B_Homo sapiens_hsa05161 | 0.81719906 |
45 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.78855550 |
46 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.75608038 |
47 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.75176339 |
48 | Hepatitis C_Homo sapiens_hsa05160 | 0.72693904 |
49 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.72211244 |
50 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.68236744 |
51 | Apoptosis_Homo sapiens_hsa04210 | 0.67594244 |
52 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.64432813 |
53 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.59448241 |
54 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.57743302 |
55 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.56420187 |
56 | Salmonella infection_Homo sapiens_hsa05132 | 0.55865922 |
57 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.55848088 |
58 | Other glycan degradation_Homo sapiens_hsa00511 | 0.54303821 |
59 | Shigellosis_Homo sapiens_hsa05131 | 0.53077421 |
60 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.52454302 |
61 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.52318363 |
62 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.51152733 |
63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.48825376 |
64 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.47260432 |
65 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.46860099 |
66 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.45849063 |
67 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.45529577 |
68 | HTLV-I infection_Homo sapiens_hsa05166 | 0.43161979 |
69 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.41407820 |
70 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.40013661 |
71 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.39875960 |
72 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.39504993 |
73 | Lysosome_Homo sapiens_hsa04142 | 0.38794773 |
74 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.38073946 |
75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36923382 |
76 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.36012312 |
77 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.34939433 |
78 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.33209247 |
79 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.33143111 |
80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.33116700 |
81 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.32869383 |
82 | Phototransduction_Homo sapiens_hsa04744 | 0.30764969 |
83 | Endocytosis_Homo sapiens_hsa04144 | 0.30573795 |
84 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.29904274 |
85 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.28769134 |
86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.27754467 |
87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.27549079 |
88 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.26407328 |
89 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.25213074 |
90 | Morphine addiction_Homo sapiens_hsa05032 | 0.24381493 |
91 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.24085015 |
92 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.23774704 |
93 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.23019042 |
94 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.21358628 |
95 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.21204864 |
96 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.20322423 |
97 | ABC transporters_Homo sapiens_hsa02010 | 0.19553473 |
98 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.19190391 |
99 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.18111674 |
100 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.17440846 |