GIMAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.23620249
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.12599493
3negative regulation of cell killing (GO:0031342)6.12599493
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.99513065
5regulation of B cell receptor signaling pathway (GO:0050855)5.75922179
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.19924469
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.12910954
8antigen processing and presentation of endogenous antigen (GO:0019883)5.08309042
9negative T cell selection (GO:0043383)4.82496816
10regulation of gamma-delta T cell activation (GO:0046643)4.78014372
11negative thymic T cell selection (GO:0045060)4.72856159
12regulation of gamma-delta T cell differentiation (GO:0045586)4.68673821
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.67280265
14cellular response to interleukin-15 (GO:0071350)4.52763086
15positive thymic T cell selection (GO:0045059)4.45523187
16response to interleukin-15 (GO:0070672)4.42049203
17T cell migration (GO:0072678)4.25628192
18activated T cell proliferation (GO:0050798)4.19933069
19positive T cell selection (GO:0043368)4.19680639
20negative regulation of T cell mediated immunity (GO:0002710)4.10311386
21leukocyte aggregation (GO:0070486)4.02887583
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96023807
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.96023807
24modulation by symbiont of host immune response (GO:0052553)3.96023807
25positive regulation by symbiont of host defense response (GO:0052509)3.96023807
26modulation by symbiont of host defense response (GO:0052031)3.96023807
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96023807
28regulation of regulatory T cell differentiation (GO:0045589)3.93147229
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.92486820
30neutrophil activation involved in immune response (GO:0002283)3.92314125
31T cell selection (GO:0045058)3.84001392
32immunoglobulin mediated immune response (GO:0016064)3.81340501
33regulation of T cell tolerance induction (GO:0002664)3.77552195
34regulation of alpha-beta T cell proliferation (GO:0046640)3.74965734
35detection of other organism (GO:0098543)3.73327347
36regulation of T cell mediated cytotoxicity (GO:0001914)3.73074360
37positive regulation of B cell differentiation (GO:0045579)3.72394063
38regulation of B cell differentiation (GO:0045577)3.71473211
39tolerance induction (GO:0002507)3.69437623
40thymic T cell selection (GO:0045061)3.69420195
41positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68029968
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.65681111
43negative regulation of interleukin-12 production (GO:0032695)3.63167928
44mast cell activation (GO:0045576)3.62363886
45detection of bacterium (GO:0016045)3.61978951
46regulation of tolerance induction (GO:0002643)3.59433290
47cellular extravasation (GO:0045123)3.54432966
48B cell receptor signaling pathway (GO:0050853)3.53965543
49regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.52169425
50regulation of natural killer cell mediated immunity (GO:0002715)3.52169425
51positive regulation of tolerance induction (GO:0002645)3.50480362
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.49638386
53interferon-gamma production (GO:0032609)3.48569995
54negative regulation of leukocyte mediated immunity (GO:0002704)3.47902796
55positive regulation of granulocyte differentiation (GO:0030854)3.47394533
56cellular response to type I interferon (GO:0071357)3.42707831
57type I interferon signaling pathway (GO:0060337)3.42707831
58microglial cell activation (GO:0001774)3.42388146
59response to type I interferon (GO:0034340)3.42352565
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.41982960
61macrophage activation involved in immune response (GO:0002281)3.40276651
62neutrophil activation (GO:0042119)3.39811107
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.33615499
64regulation of leukocyte mediated cytotoxicity (GO:0001910)3.33169245
65antigen receptor-mediated signaling pathway (GO:0050851)3.30598713
66interferon-gamma-mediated signaling pathway (GO:0060333)3.28177823
67myeloid cell activation involved in immune response (GO:0002275)3.20707362
68T cell receptor signaling pathway (GO:0050852)3.20080192
69positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.19923088
70response to host immune response (GO:0052572)3.18930845
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18930845
72antigen processing and presentation via MHC class Ib (GO:0002475)3.14116245
73respiratory burst (GO:0045730)3.11975821
74positive regulation of antigen processing and presentation (GO:0002579)3.10780970
75regulation of antigen processing and presentation (GO:0002577)3.09750688
76regulation of interferon-beta biosynthetic process (GO:0045357)3.08840147
77granulocyte activation (GO:0036230)3.06610497
78detection of external biotic stimulus (GO:0098581)3.06553634
79negative regulation of innate immune response (GO:0045824)3.06277684
80regulation of cell killing (GO:0031341)3.04877376
81B cell mediated immunity (GO:0019724)3.04660849
82leukocyte degranulation (GO:0043299)3.03562222
83response to peptidoglycan (GO:0032494)3.01968371
84regulation of isotype switching to IgG isotypes (GO:0048302)2.99746454
85negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99552293
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97569979
87dendritic cell chemotaxis (GO:0002407)2.91125398
88positive regulation of cell killing (GO:0031343)2.89775718
89dendritic cell migration (GO:0036336)2.88897512
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86159118
91response to host (GO:0075136)2.86159118
92response to host defenses (GO:0052200)2.86159118
93T cell costimulation (GO:0031295)2.85719361
94cytidine deamination (GO:0009972)2.85311711
95cytidine metabolic process (GO:0046087)2.85311711
96cytidine catabolic process (GO:0006216)2.85311711
97detection of biotic stimulus (GO:0009595)2.85197701
98defense response to protozoan (GO:0042832)2.84873541
99regulation of alpha-beta T cell activation (GO:0046634)2.84795562
100regulation of T cell mediated immunity (GO:0002709)2.84292949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.92361900
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.37188922
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.69481602
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.22502258
5* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.21006995
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.19665849
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.47219887
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45901956
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16421934
10* MYB_26560356_Chip-Seq_TH2_Human2.96207597
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89081267
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.78923875
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57838797
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.47485102
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43621111
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39719900
17SCL_19346495_ChIP-Seq_HPC-7_Human2.36895945
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34930956
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30531482
20SPI1_23547873_ChIP-Seq_NB4_Human2.27955405
21MYB_26560356_Chip-Seq_TH1_Human2.27142004
22GATA3_27048872_Chip-Seq_THYMUS_Human2.21000584
23* MAF_26560356_Chip-Seq_TH1_Human2.07556115
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06310684
25GATA3_26560356_Chip-Seq_TH2_Human2.02387601
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95335251
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93321790
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89403786
29UTX_26944678_Chip-Seq_JUKART_Human1.86816934
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86592847
31SPI1_23127762_ChIP-Seq_K562_Human1.82148890
32VDR_24763502_ChIP-Seq_THP-1_Human1.72331363
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.63943330
34VDR_24787735_ChIP-Seq_THP-1_Human1.62778512
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61984781
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61642500
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58877108
38GATA1_22025678_ChIP-Seq_K562_Human1.53593995
39* NOTCH1_21737748_ChIP-Seq_TLL_Human1.52640271
40MAF_26560356_Chip-Seq_TH2_Human1.52565732
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.52496476
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42033735
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41525585
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38118044
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35815634
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35744163
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32917967
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31791772
49VDR_21846776_ChIP-Seq_THP-1_Human1.30898151
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29238373
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22621108
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17588370
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14552011
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13667085
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10479389
56MYC_22102868_ChIP-Seq_BL_Human1.07935935
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06419086
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05504660
59CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03287864
60PU_27001747_Chip-Seq_BMDM_Mouse1.02669326
61SMRT_27268052_Chip-Seq_Bcells_Human1.02650702
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.01346170
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00701248
64CIITA_25753668_ChIP-Seq_RAJI_Human0.97816442
65IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96896393
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96432083
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95309644
68* BCL6_27268052_Chip-Seq_Bcells_Human0.94526388
69* GATA3_26560356_Chip-Seq_TH1_Human0.93152605
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88915125
71FLI1_27457419_Chip-Seq_LIVER_Mouse0.88604298
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87113615
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86970461
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.86476014
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85210735
76* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84566284
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83133695
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82593547
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82274589
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80563080
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80388725
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79975600
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79399003
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77908779
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.77830936
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77593665
87TCF7_22412390_ChIP-Seq_EML_Mouse0.77450790
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77059563
89GATA1_19941826_ChIP-Seq_K562_Human0.76613024
90STAT1_20625510_ChIP-Seq_HELA_Human0.76010999
91* P300_27268052_Chip-Seq_Bcells_Human0.74346024
92VDR_23849224_ChIP-Seq_CD4+_Human0.74101583
93SPI1_20517297_ChIP-Seq_HL60_Human0.72773856
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69989658
95VDR_22108803_ChIP-Seq_LS180_Human0.69216604
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68516711
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68412585
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68126347
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67213199
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.66345363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.75986801
2MP0001835_abnormal_antigen_presentation4.24616040
3MP0005671_abnormal_response_to4.19530811
4MP0003436_decreased_susceptibility_to3.45171378
5MP0001800_abnormal_humoral_immune3.37043493
6MP0003763_abnormal_thymus_physiology3.28264507
7MP0005000_abnormal_immune_tolerance3.19567353
8MP0009785_altered_susceptibility_to3.12394054
9MP0000685_abnormal_immune_system2.98795906
10MP0002723_abnormal_immune_serum2.87895487
11MP0005387_immune_system_phenotype2.83686509
12MP0001790_abnormal_immune_system2.83686509
13MP0006082_CNS_inflammation2.83609828
14MP0005025_abnormal_response_to2.80085370
15MP0002419_abnormal_innate_immunity2.71559438
16MP0002420_abnormal_adaptive_immunity2.71387689
17MP0002452_abnormal_antigen_presenting2.69732885
18MP0002148_abnormal_hypersensitivity_rea2.68457144
19MP0001819_abnormal_immune_cell2.68229763
20MP0003303_peritoneal_inflammation2.42128027
21MP0002398_abnormal_bone_marrow2.14503931
22MP0002405_respiratory_system_inflammati2.13528617
23MP0000716_abnormal_immune_system2.12896307
24MP0010155_abnormal_intestine_physiology2.01878681
25MP0009333_abnormal_splenocyte_physiolog2.00440881
26MP0005464_abnormal_platelet_physiology1.95029733
27MP0003866_abnormal_defecation1.93040067
28MP0000689_abnormal_spleen_morphology1.89668429
29MP0001845_abnormal_inflammatory_respons1.84617739
30MP0002166_altered_tumor_susceptibility1.82040281
31MP0001533_abnormal_skeleton_physiology1.77953785
32MP0002722_abnormal_immune_system1.74202892
33MP0000703_abnormal_thymus_morphology1.72034392
34MP0000465_gastrointestinal_hemorrhage1.70752511
35MP0003300_gastrointestinal_ulcer1.63391543
36MP0002429_abnormal_blood_cell1.63204999
37MP0004947_skin_inflammation1.55711501
38MP0001873_stomach_inflammation1.51367593
39MP0009764_decreased_sensitivity_to1.50340043
40MP0008469_abnormal_protein_level1.44373012
41MP0002138_abnormal_hepatobiliary_system1.41157043
42MP0004381_abnormal_hair_follicle1.39830004
43MP0002277_abnormal_respiratory_mucosa1.37246814
44MP0005310_abnormal_salivary_gland1.33596250
45MP0005075_abnormal_melanosome_morpholog1.33079614
46MP0002933_joint_inflammation1.24679460
47MP0002396_abnormal_hematopoietic_system1.22064510
48MP0002006_tumorigenesis1.21272774
49MP0003172_abnormal_lysosome_physiology1.18919055
50MP0003787_abnormal_imprinting1.16715569
51MP0001986_abnormal_taste_sensitivity1.11599744
52MP0003183_abnormal_peptide_metabolism1.11522091
53MP0002009_preneoplasia1.10614169
54MP0003191_abnormal_cellular_cholesterol1.09310339
55MP0003828_pulmonary_edema1.08548761
56MP0009278_abnormal_bone_marrow1.08164263
57MP0001851_eye_inflammation1.08117053
58MP0002132_abnormal_respiratory_system1.07240947
59MP0002998_abnormal_bone_remodeling1.00758585
60MP0000858_altered_metastatic_potential0.96554855
61MP0004883_abnormal_blood_vessel0.94214453
62MP0009763_increased_sensitivity_to0.91959723
63MP0005397_hematopoietic_system_phenotyp0.89468888
64MP0001545_abnormal_hematopoietic_system0.89468888
65MP0001663_abnormal_digestive_system0.87848643
66MP0001853_heart_inflammation0.86269971
67MP0000569_abnormal_digit_pigmentation0.85404869
68MP0005166_decreased_susceptibility_to0.80951233
69MP0004130_abnormal_muscle_cell0.75460111
70MP0003448_altered_tumor_morphology0.75143357
71MP0003690_abnormal_glial_cell0.72609512
72MP0004808_abnormal_hematopoietic_stem0.72564335
73MP0008877_abnormal_DNA_methylation0.72512804
74MP0009765_abnormal_xenobiotic_induced0.72062499
75MP0008260_abnormal_autophagy0.71447821
76MP0002693_abnormal_pancreas_physiology0.70860824
77MP0000015_abnormal_ear_pigmentation0.68880347
78MP0005390_skeleton_phenotype0.67647738
79MP0003075_altered_response_to0.66499438
80MP0000343_altered_response_to0.65386134
81MP0003806_abnormal_nucleotide_metabolis0.64938003
82MP0000249_abnormal_blood_vessel0.62703307
83MP0003252_abnormal_bile_duct0.61534762
84MP0005164_abnormal_response_to0.60318186
85MP0002019_abnormal_tumor_incidence0.58886007
86MP0004484_altered_response_of0.55197782
87MP0005084_abnormal_gallbladder_morpholo0.55148472
88MP0003195_calcinosis0.54471577
89MP0002163_abnormal_gland_morphology0.53406859
90MP0005174_abnormal_tail_pigmentation0.53235077
91MP0003795_abnormal_bone_structure0.51527767
92MP0001765_abnormal_ion_homeostasis0.50902327
93MP0003045_fibrosis0.50720149
94MP0000604_amyloidosis0.49753408
95MP0000490_abnormal_crypts_of0.49693568
96MP0000372_irregular_coat_pigmentation0.49655056
97MP0002928_abnormal_bile_duct0.49325033
98MP0005085_abnormal_gallbladder_physiolo0.48975723
99MP0002136_abnormal_kidney_physiology0.48920675
100MP0008873_increased_physiological_sensi0.47253742

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.40961718
2T lymphocytopenia (HP:0005403)5.35051196
3Stomatitis (HP:0010280)5.33576029
4Abnormality of T cell number (HP:0011839)5.16492245
5Recurrent abscess formation (HP:0002722)5.05551296
6Myositis (HP:0100614)5.00618367
7Recurrent bacterial skin infections (HP:0005406)4.93966427
8Eczematoid dermatitis (HP:0000976)4.91574304
9Optic neuritis (HP:0100653)4.56342163
10Retrobulbar optic neuritis (HP:0100654)4.56342163
11Orchitis (HP:0100796)4.38602347
12Recurrent fungal infections (HP:0002841)4.31554377
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.27043872
14Gastrointestinal infarctions (HP:0005244)4.17678567
15Abnormality of T cells (HP:0002843)4.03276600
16Encephalitis (HP:0002383)3.99786132
17Panhypogammaglobulinemia (HP:0003139)3.98268579
18Abnormality of macrophages (HP:0004311)3.95799622
19Recurrent cutaneous fungal infections (HP:0011370)3.94700768
20Chronic mucocutaneous candidiasis (HP:0002728)3.94700768
21Meningitis (HP:0001287)3.90528316
22Mediastinal lymphadenopathy (HP:0100721)3.78127011
23Recurrent skin infections (HP:0001581)3.65462196
24Vasculitis (HP:0002633)3.63526834
25Severe combined immunodeficiency (HP:0004430)3.56132037
26Leukocytosis (HP:0001974)3.55032659
27Spontaneous hematomas (HP:0007420)3.52355998
28Obstructive lung disease (HP:0006536)3.49184617
29Chronic obstructive pulmonary disease (HP:0006510)3.49184617
30Recurrent gram-negative bacterial infections (HP:0005420)3.45518160
31IgG deficiency (HP:0004315)3.35996155
32Pulmonary infiltrates (HP:0002113)3.34417149
33Recurrent viral infections (HP:0004429)3.33225846
34Pustule (HP:0200039)3.30950087
35Keratoconjunctivitis sicca (HP:0001097)3.29688625
36Hemoptysis (HP:0002105)3.25560600
37Autoimmune hemolytic anemia (HP:0001890)3.23759598
38Keratoconjunctivitis (HP:0001096)3.23650984
39Abnormality of eosinophils (HP:0001879)3.22585806
40Recurrent bronchitis (HP:0002837)3.09685732
41Chest pain (HP:0100749)3.08299157
42Eosinophilia (HP:0001880)3.05458730
43Increased IgM level (HP:0003496)3.05200192
44Granulocytopenia (HP:0001913)3.04015604
45Abnormality of the prostate (HP:0008775)2.92197327
46Agammaglobulinemia (HP:0004432)2.91406982
47Abnormality of B cell number (HP:0010975)2.86516708
48Pulmonary embolism (HP:0002204)2.84758264
49Abnormality of T cell physiology (HP:0011840)2.84585928
50Prolonged bleeding time (HP:0003010)2.78327066
51Urticaria (HP:0001025)2.74646081
52Combined immunodeficiency (HP:0005387)2.73573915
53Papilledema (HP:0001085)2.72304530
54Inflammation of the large intestine (HP:0002037)2.69404092
55Arterial thrombosis (HP:0004420)2.67842682
56Chronic otitis media (HP:0000389)2.66426248
57Thyroiditis (HP:0100646)2.62966483
58Stomach cancer (HP:0012126)2.62416652
59Epistaxis (HP:0000421)2.59272123
60Chronic diarrhea (HP:0002028)2.58704934
61Lymphopenia (HP:0001888)2.56402743
62Gangrene (HP:0100758)2.52600777
63Anorexia (HP:0002039)2.51770389
64Autoimmune thrombocytopenia (HP:0001973)2.51220563
65Joint swelling (HP:0001386)2.49040714
66Gastrointestinal inflammation (HP:0004386)2.47558036
67B lymphocytopenia (HP:0010976)2.44242841
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.43873420
69Hypochromic anemia (HP:0001931)2.43007788
70Abnormality of the pleura (HP:0002103)2.42064608
71Gingivitis (HP:0000230)2.40740420
72Increased IgE level (HP:0003212)2.39841627
73Gingival bleeding (HP:0000225)2.33933514
74IgM deficiency (HP:0002850)2.33857064
75Episodic fever (HP:0001954)2.17771160
76Colitis (HP:0002583)2.17299221
77Hypoproteinemia (HP:0003075)2.15277564
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15182427
79Hypergammaglobulinemia (HP:0010702)2.12944148
80Microcytic anemia (HP:0001935)2.12443544
81Hypochromic microcytic anemia (HP:0004840)2.10545815
82Glomerulopathy (HP:0100820)2.02339426
83Acute hepatic failure (HP:0006554)2.01166045
84Polyneuropathy (HP:0001271)2.00431997
85Hypoplasia of the thymus (HP:0000778)2.00099284
86Cellulitis (HP:0100658)1.99731122
87Vertigo (HP:0002321)1.99297982
88Keratitis (HP:0000491)1.99259123
89Sepsis (HP:0100806)1.99182414
90Alveolar cell carcinoma (HP:0006519)1.96867064
91Bronchitis (HP:0012387)1.95878278
92Verrucae (HP:0200043)1.95552133
93Papilloma (HP:0012740)1.95552133
94Recurrent sinusitis (HP:0011108)1.95349118
95Hemiplegia (HP:0002301)1.91995494
96Skin rash (HP:0000988)1.91721289
97Neoplasm of the tracheobronchial system (HP:0100552)1.87657362
98Amaurosis fugax (HP:0100576)1.85944701
99Abnormality of iron homeostasis (HP:0011031)1.85326056
100Osteomyelitis (HP:0002754)1.84608678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.44316503
2TXK4.20908592
3RIPK43.93129733
4TAOK33.60284900
5FES3.08539023
6GRK62.44228725
7TYK22.42337429
8BLK2.34327243
9BTK2.31069598
10CSK2.29992475
11SYK2.29820425
12IKBKE2.23757781
13ITK2.17150498
14TEC2.09001948
15KIT2.07289228
16JAK32.00484811
17TNK21.99443714
18ZAP701.98823476
19MAP3K141.94599168
20IRAK41.92311248
21JAK11.84656474
22LCK1.66417689
23LYN1.61005633
24CAMKK21.58302727
25HCK1.57045095
26BMPR21.47947550
27IKBKB1.46050907
28TBK11.42390804
29CSF1R1.40285163
30TLK11.36782311
31MAP2K31.32803213
32PRKCQ1.22511173
33JAK21.12890881
34MARK31.09828221
35ADRBK21.07850912
36FRK1.05143193
37MATK1.00596625
38GRK70.94633746
39PRPF4B0.92973613
40NLK0.91210173
41CAMKK10.90485276
42MAP3K110.90465496
43FGR0.90419153
44PIK3CG0.87149267
45SIK20.85750339
46PASK0.83659165
47CDK190.83263033
48MAP3K130.81067578
49PIM10.78980529
50KDR0.75431350
51MAP2K20.74544595
52NUAK10.73865744
53TESK20.70718259
54FGFR30.69836796
55EPHB10.64637167
56PDK10.64502965
57IRAK10.62981415
58FYN0.62905325
59SIK30.62367733
60TGFBR20.59116480
61MAP3K10.57290186
62MAP2K60.57062558
63MUSK0.57023290
64ERN10.54517301
65HIPK20.53465781
66MAPK70.52604877
67PINK10.49857880
68RPS6KA60.49837955
69MAP3K30.49365661
70PRKCH0.47779516
71STK100.45916473
72STK110.45801025
73ZAK0.44168318
74ACVR1B0.44131507
75ABL10.44002017
76DAPK20.43553174
77MAP3K70.41482950
78MAP3K60.40953249
79MAP3K50.39938049
80RPS6KL10.39779036
81RPS6KC10.39779036
82TAOK10.39716965
83MAPK120.38627277
84YES10.37897329
85MAP4K20.37507253
86CDK40.35423350
87BCKDK0.34598091
88MARK20.34568659
89TYRO30.32491235
90FGFR40.32452718
91EPHA30.32415015
92LRRK20.31961651
93PRKCD0.31455353
94ADRBK10.31443955
95MAPK110.31271828
96PTK2B0.31125492
97CHUK0.31110576
98IGF1R0.31086537
99OXSR10.29203835
100MAPK40.28823030

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.00052410
2Graft-versus-host disease_Homo sapiens_hsa053323.51060004
3Allograft rejection_Homo sapiens_hsa053303.41674534
4Autoimmune thyroid disease_Homo sapiens_hsa053203.24569908
5Leishmaniasis_Homo sapiens_hsa051402.69770877
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.65293171
7Staphylococcus aureus infection_Homo sapiens_hsa051502.61539652
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.59676178
9Type I diabetes mellitus_Homo sapiens_hsa049402.56917664
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.55341271
11Asthma_Homo sapiens_hsa053102.42253683
12Antigen processing and presentation_Homo sapiens_hsa046122.35192848
13T cell receptor signaling pathway_Homo sapiens_hsa046602.31043853
14Osteoclast differentiation_Homo sapiens_hsa043802.28867774
15Hematopoietic cell lineage_Homo sapiens_hsa046402.20436340
16B cell receptor signaling pathway_Homo sapiens_hsa046622.03433076
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.97220010
18Measles_Homo sapiens_hsa051621.95662047
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94455638
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80011963
21Viral myocarditis_Homo sapiens_hsa054161.70968334
22Tuberculosis_Homo sapiens_hsa051521.68461610
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68225121
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64885558
25Rheumatoid arthritis_Homo sapiens_hsa053231.55627673
26Malaria_Homo sapiens_hsa051441.53565397
27Chemokine signaling pathway_Homo sapiens_hsa040621.50628688
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.49585909
29Herpes simplex infection_Homo sapiens_hsa051681.40654198
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38001808
31Influenza A_Homo sapiens_hsa051641.35221894
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34824242
33Toxoplasmosis_Homo sapiens_hsa051451.32608076
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28731338
35Legionellosis_Homo sapiens_hsa051341.15767782
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15500474
37TNF signaling pathway_Homo sapiens_hsa046681.13819171
38Platelet activation_Homo sapiens_hsa046111.08969421
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08634213
40Acute myeloid leukemia_Homo sapiens_hsa052210.93826682
41African trypanosomiasis_Homo sapiens_hsa051430.91166231
42Phagosome_Homo sapiens_hsa041450.91035486
43Pertussis_Homo sapiens_hsa051330.88742311
44Hepatitis B_Homo sapiens_hsa051610.81719906
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78855550
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75608038
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75176339
48Hepatitis C_Homo sapiens_hsa051600.72693904
49Linoleic acid metabolism_Homo sapiens_hsa005910.72211244
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.68236744
51Apoptosis_Homo sapiens_hsa042100.67594244
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64432813
53Epstein-Barr virus infection_Homo sapiens_hsa051690.59448241
54Dorso-ventral axis formation_Homo sapiens_hsa043200.57743302
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56420187
56Salmonella infection_Homo sapiens_hsa051320.55865922
57Non-small cell lung cancer_Homo sapiens_hsa052230.55848088
58Other glycan degradation_Homo sapiens_hsa005110.54303821
59Shigellosis_Homo sapiens_hsa051310.53077421
60Prolactin signaling pathway_Homo sapiens_hsa049170.52454302
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52318363
62Arachidonic acid metabolism_Homo sapiens_hsa005900.51152733
63Regulation of autophagy_Homo sapiens_hsa041400.48825376
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47260432
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46860099
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45849063
67Systemic lupus erythematosus_Homo sapiens_hsa053220.45529577
68HTLV-I infection_Homo sapiens_hsa051660.43161979
69Ether lipid metabolism_Homo sapiens_hsa005650.41407820
70MAPK signaling pathway_Homo sapiens_hsa040100.40013661
71Nitrogen metabolism_Homo sapiens_hsa009100.39875960
72Caffeine metabolism_Homo sapiens_hsa002320.39504993
73Lysosome_Homo sapiens_hsa041420.38794773
74VEGF signaling pathway_Homo sapiens_hsa043700.38073946
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36923382
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.36012312
77Pancreatic cancer_Homo sapiens_hsa052120.34939433
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33209247
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33143111
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.33116700
81Viral carcinogenesis_Homo sapiens_hsa052030.32869383
82Phototransduction_Homo sapiens_hsa047440.30764969
83Endocytosis_Homo sapiens_hsa041440.30573795
84FoxO signaling pathway_Homo sapiens_hsa040680.29904274
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28769134
86Olfactory transduction_Homo sapiens_hsa047400.27754467
87Collecting duct acid secretion_Homo sapiens_hsa049660.27549079
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26407328
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.25213074
90Morphine addiction_Homo sapiens_hsa050320.24381493
91Choline metabolism in cancer_Homo sapiens_hsa052310.24085015
92Ras signaling pathway_Homo sapiens_hsa040140.23774704
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.23019042
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.21358628
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21204864
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.20322423
97ABC transporters_Homo sapiens_hsa020100.19553473
98Type II diabetes mellitus_Homo sapiens_hsa049300.19190391
99Cholinergic synapse_Homo sapiens_hsa047250.18111674
100Glycerolipid metabolism_Homo sapiens_hsa005610.17440846

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