GIMAP3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.33912093
2negative T cell selection (GO:0043383)6.65534140
3positive regulation of gamma-delta T cell activation (GO:0046645)6.52059254
4negative thymic T cell selection (GO:0045060)5.72571177
5positive T cell selection (GO:0043368)5.67550775
6negative regulation of cell killing (GO:0031342)5.49994820
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.49994820
8regulation of isotype switching to IgG isotypes (GO:0048302)5.48958446
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44567825
10regulation of gamma-delta T cell differentiation (GO:0045586)5.12335776
11cellular response to interleukin-15 (GO:0071350)4.95339602
12regulation of gamma-delta T cell activation (GO:0046643)4.91173198
13alpha-beta T cell differentiation (GO:0046632)4.85721209
14T cell selection (GO:0045058)4.81214746
15regulation of regulatory T cell differentiation (GO:0045589)4.75909610
16regulation of T cell receptor signaling pathway (GO:0050856)4.71101856
17response to interleukin-15 (GO:0070672)4.63504734
18thymic T cell selection (GO:0045061)4.62862196
19positive thymic T cell selection (GO:0045059)4.52519220
20regulation of T cell tolerance induction (GO:0002664)4.50330995
21regulation of interleukin-12 biosynthetic process (GO:0045075)4.49670306
22positive regulation of humoral immune response (GO:0002922)4.45255709
23regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.44281190
24positive regulation of tolerance induction (GO:0002645)4.43479342
25alpha-beta T cell activation (GO:0046631)4.23302918
26tolerance induction (GO:0002507)4.19515060
27interferon-gamma production (GO:0032609)4.15231237
28regulation of alpha-beta T cell proliferation (GO:0046640)4.12093913
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06147698
30response to muramyl dipeptide (GO:0032495)3.89249784
31T cell differentiation involved in immune response (GO:0002292)3.86593963
32alpha-beta T cell differentiation involved in immune response (GO:0002293)3.86593963
33alpha-beta T cell activation involved in immune response (GO:0002287)3.86593963
34antigen processing and presentation of endogenous antigen (GO:0019883)3.86139021
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.82850119
36regulation of tolerance induction (GO:0002643)3.81352672
37regulation of B cell receptor signaling pathway (GO:0050855)3.80776332
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.79995805
39regulation of interleukin-1 beta secretion (GO:0050706)3.73516091
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.70565039
41negative regulation of thymocyte apoptotic process (GO:0070244)3.69497811
42positive regulation of T cell differentiation in thymus (GO:0033089)3.69079608
43regulation of cellular extravasation (GO:0002691)3.60139107
44defense response to protozoan (GO:0042832)3.59631500
45myeloid dendritic cell differentiation (GO:0043011)3.58734935
46positive regulation of antigen processing and presentation (GO:0002579)3.52638719
47myeloid dendritic cell activation (GO:0001773)3.46246679
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45837800
49positive regulation of isotype switching (GO:0045830)3.44100298
50positive regulation of DNA recombination (GO:0045911)3.39694928
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.37023314
52regulation of germinal center formation (GO:0002634)3.35895807
53T cell migration (GO:0072678)3.34976312
54regulation of interleukin-1 secretion (GO:0050704)3.28384779
55regulation of hypersensitivity (GO:0002883)3.25597200
56positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.20118151
57regulation of interleukin-6 biosynthetic process (GO:0045408)3.19341102
58T cell differentiation (GO:0030217)3.18630174
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.18122531
60regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.16766005
61negative regulation of T cell receptor signaling pathway (GO:0050860)3.16743529
62regulation of response to interferon-gamma (GO:0060330)3.15276405
63T cell receptor signaling pathway (GO:0050852)3.14544526
64leukocyte aggregation (GO:0070486)3.13401130
65regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.12322297
66antigen processing and presentation via MHC class Ib (GO:0002475)3.09826532
67response to protozoan (GO:0001562)3.08658001
68regulation of T cell mediated cytotoxicity (GO:0001914)3.07709708
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06038794
70activated T cell proliferation (GO:0050798)3.04787957
71negative regulation of bone resorption (GO:0045779)3.02110873
72negative regulation of T cell apoptotic process (GO:0070233)3.02012085
73regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.01587862
74positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.01587862
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99514852
76mature B cell differentiation involved in immune response (GO:0002313)2.98745173
77positive regulation of B cell mediated immunity (GO:0002714)2.98607411
78positive regulation of immunoglobulin mediated immune response (GO:0002891)2.98607411
79antigen receptor-mediated signaling pathway (GO:0050851)2.98575698
80negative regulation of T cell mediated immunity (GO:0002710)2.98275487
81histone H3-K36 demethylation (GO:0070544)2.97435262
82regulation of B cell differentiation (GO:0045577)2.95640153
83positive regulation of interleukin-12 production (GO:0032735)2.94853776
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.94839284
85adaptation of signaling pathway (GO:0023058)2.90702847
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.90121997
87T-helper cell differentiation (GO:0042093)2.90121997
88regulation of interleukin-1 beta production (GO:0032651)2.89680216
89negative regulation of lymphocyte mediated immunity (GO:0002707)2.89576824
90regulation of thymocyte apoptotic process (GO:0070243)2.88213422
91dendritic cell differentiation (GO:0097028)2.87774581
92regulation of antigen processing and presentation (GO:0002577)2.87339593
93immunoglobulin mediated immune response (GO:0016064)2.85368150
94regulation of natural killer cell mediated immunity (GO:0002715)2.85152818
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85152818
96lymphocyte migration (GO:0072676)2.84042126
97CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.82067043
98negative regulation of interleukin-1 beta production (GO:0032691)2.80739710
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.80151038
100cellular response to exogenous dsRNA (GO:0071360)2.80025660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.59333561
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.06384756
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.08228489
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.34321781
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.84274051
6RUNX_20019798_ChIP-Seq_JUKART_Human3.70947543
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.29888555
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80166552
9MYB_26560356_Chip-Seq_TH2_Human2.65647214
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.63985296
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60859909
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.58090437
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41107646
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31998311
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21720495
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.18090254
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16150880
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15306415
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.12913691
20MAF_26560356_Chip-Seq_TH1_Human2.11813602
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05545393
22GATA3_27048872_Chip-Seq_THYMUS_Human2.05002057
23GATA1_22025678_ChIP-Seq_K562_Human1.99166321
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97728879
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.97050235
26MYB_26560356_Chip-Seq_TH1_Human1.95215074
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93217943
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92686218
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87665576
30GATA3_26560356_Chip-Seq_TH2_Human1.82427112
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79651712
32UTX_26944678_Chip-Seq_JUKART_Human1.73183695
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.70964206
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.67087868
35SCL_19346495_ChIP-Seq_HPC-7_Human1.65283553
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59825228
37MAF_26560356_Chip-Seq_TH2_Human1.59503630
38SPI1_23547873_ChIP-Seq_NB4_Human1.59215793
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52798602
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49003671
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48933168
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41110745
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39167825
44CIITA_25753668_ChIP-Seq_RAJI_Human1.37986848
45SPI1_23127762_ChIP-Seq_K562_Human1.37979495
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.32633985
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31042293
48VDR_24787735_ChIP-Seq_THP-1_Human1.30008363
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29973499
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26603742
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24323792
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15964362
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14529140
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13258041
55VDR_23849224_ChIP-Seq_CD4+_Human1.12564191
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09590623
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08216565
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07912375
59PU_27001747_Chip-Seq_BMDM_Mouse1.07793082
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.06695231
61VDR_24763502_ChIP-Seq_THP-1_Human1.03382127
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02929277
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02776707
64BCL6_27268052_Chip-Seq_Bcells_Human1.02663320
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02169314
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00983018
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93232454
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92819105
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92353328
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88757478
71TCF7_22412390_ChIP-Seq_EML_Mouse0.88469087
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87938351
73P300_27268052_Chip-Seq_Bcells_Human0.86147529
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85091312
75IGF1R_20145208_ChIP-Seq_DFB_Human0.83844035
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82872821
77PRDM14_20953172_ChIP-Seq_ESCs_Human0.79632507
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77818831
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76346887
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76206592
81FOXP3_21729870_ChIP-Seq_TREG_Human0.75101201
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74508297
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73245447
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72711640
85GATA3_26560356_Chip-Seq_TH1_Human0.70860855
86SPI1_20517297_ChIP-Seq_HL60_Human0.70238728
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.70184205
88IRF1_19129219_ChIP-ChIP_H3396_Human0.69795665
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67800985
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.67243298
91MYC_22102868_ChIP-Seq_BL_Human0.67212856
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.66754690
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66300720
94YY1_22570637_ChIP-Seq_MALME-3M_Human0.65672185
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65337401
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64853965
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.62772356
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.62425363
99SMRT_27268052_Chip-Seq_Bcells_Human0.61827797
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61684873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.75185612
2MP0003724_increased_susceptibility_to4.35865163
3MP0001835_abnormal_antigen_presentation4.03642794
4MP0003763_abnormal_thymus_physiology3.66707563
5MP0002166_altered_tumor_susceptibility3.61168090
6MP0003436_decreased_susceptibility_to3.54550403
7MP0001873_stomach_inflammation3.25373019
8MP0005000_abnormal_immune_tolerance3.06498696
9MP0001800_abnormal_humoral_immune2.81666447
10MP0001348_abnormal_lacrimal_gland2.80289742
11MP0000685_abnormal_immune_system2.75115729
12MP0002009_preneoplasia2.72610851
13MP0005167_abnormal_blood-brain_barrier2.71120078
14MP0009785_altered_susceptibility_to2.54282401
15MP0002006_tumorigenesis2.53996022
16MP0009333_abnormal_splenocyte_physiolog2.53842913
17MP0002933_joint_inflammation2.50541954
18MP0002723_abnormal_immune_serum2.45973329
19MP0002420_abnormal_adaptive_immunity2.39631265
20MP0002148_abnormal_hypersensitivity_rea2.36735918
21MP0001790_abnormal_immune_system2.36676919
22MP0005387_immune_system_phenotype2.36676919
23MP0001819_abnormal_immune_cell2.35441969
24MP0002452_abnormal_antigen_presenting2.26092471
25MP0002419_abnormal_innate_immunity2.23774616
26MP0010155_abnormal_intestine_physiology2.13888174
27MP0002405_respiratory_system_inflammati2.11817922
28MP0003866_abnormal_defecation2.05410495
29MP0005025_abnormal_response_to2.05110763
30MP0001533_abnormal_skeleton_physiology1.88567002
31MP0000703_abnormal_thymus_morphology1.85207051
32MP0000465_gastrointestinal_hemorrhage1.82848566
33MP0002163_abnormal_gland_morphology1.80894202
34MP0003172_abnormal_lysosome_physiology1.80643639
35MP0002398_abnormal_bone_marrow1.78139477
36MP0006082_CNS_inflammation1.73479694
37MP0000716_abnormal_immune_system1.71709206
38MP0000569_abnormal_digit_pigmentation1.70291824
39MP0000689_abnormal_spleen_morphology1.64853966
40MP0002722_abnormal_immune_system1.62008506
41MP0003828_pulmonary_edema1.61787589
42MP0005310_abnormal_salivary_gland1.58762346
43MP0001346_abnormal_lacrimal_gland1.54826549
44MP0000015_abnormal_ear_pigmentation1.48982061
45MP0001845_abnormal_inflammatory_respons1.41946567
46MP0002429_abnormal_blood_cell1.38405626
47MP0003656_abnormal_erythrocyte_physiolo1.38263071
48MP0003252_abnormal_bile_duct1.34746306
49MP0004782_abnormal_surfactant_physiolog1.34240967
50MP0003303_peritoneal_inflammation1.27753611
51MP0004947_skin_inflammation1.20854829
52MP0008872_abnormal_physiological_respon1.16455477
53MP0009840_abnormal_foam_cell1.13261236
54MP0009764_decreased_sensitivity_to1.04620885
55MP0001663_abnormal_digestive_system1.04557987
56MP0005464_abnormal_platelet_physiology1.03150746
57MP0002254_reproductive_system_inflammat1.00163027
58MP0008469_abnormal_protein_level0.99928116
59MP0002138_abnormal_hepatobiliary_system0.97923863
60MP0009278_abnormal_bone_marrow0.92699242
61MP0002332_abnormal_exercise_endurance0.89764654
62MP0001958_emphysema0.88392078
63MP0002998_abnormal_bone_remodeling0.88048935
64MP0000249_abnormal_blood_vessel0.84643495
65MP0001851_eye_inflammation0.84151430
66MP0003690_abnormal_glial_cell0.83862944
67MP0004381_abnormal_hair_follicle0.81629171
68MP0004130_abnormal_muscle_cell0.78536592
69MP0005379_endocrine/exocrine_gland_phen0.74895826
70MP0002693_abnormal_pancreas_physiology0.73274497
71MP0001879_abnormal_lymphatic_vessel0.72938748
72MP0003646_muscle_fatigue0.72358467
73MP0002876_abnormal_thyroid_physiology0.72103028
74MP0010307_abnormal_tumor_latency0.71342404
75MP0005390_skeleton_phenotype0.70903777
76MP0002133_abnormal_respiratory_system0.65220819
77MP0005388_respiratory_system_phenotype0.65220819
78MP0001765_abnormal_ion_homeostasis0.64336783
79MP0003191_abnormal_cellular_cholesterol0.64274208
80MP0005645_abnormal_hypothalamus_physiol0.63644452
81MP0005381_digestive/alimentary_phenotyp0.61440348
82MP0003950_abnormal_plasma_membrane0.61237762
83MP0004883_abnormal_blood_vessel0.60862895
84MP0002928_abnormal_bile_duct0.60681351
85MP0005075_abnormal_melanosome_morpholog0.60535001
86MP0001501_abnormal_sleep_pattern0.60436328
87MP0003300_gastrointestinal_ulcer0.60083176
88MP0001661_extended_life_span0.58847308
89MP0005174_abnormal_tail_pigmentation0.58132503
90MP0003795_abnormal_bone_structure0.57936166
91MP0006072_abnormal_retinal_apoptosis0.56207891
92MP0005166_decreased_susceptibility_to0.52951222
93MP0008789_abnormal_olfactory_epithelium0.51919448
94MP0003448_altered_tumor_morphology0.50694114
95MP0001919_abnormal_reproductive_system0.49387495
96MP0000613_abnormal_salivary_gland0.48769470
97MP0004036_abnormal_muscle_relaxation0.48279368
98MP0002019_abnormal_tumor_incidence0.46469141
99MP0000470_abnormal_stomach_morphology0.45478166
100MP0002136_abnormal_kidney_physiology0.44955855

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.83795774
2Abnormality of T cell number (HP:0011839)5.38620599
3Stomatitis (HP:0010280)5.17793342
4Elevated erythrocyte sedimentation rate (HP:0003565)5.05546573
5Congenital, generalized hypertrichosis (HP:0004540)5.05325632
6Renal cortical cysts (HP:0000803)4.52457718
7Chronic mucocutaneous candidiasis (HP:0002728)4.26273763
8Recurrent cutaneous fungal infections (HP:0011370)4.26273763
9Abnormality of secondary sexual hair (HP:0009888)4.18479698
10Abnormality of the axillary hair (HP:0100134)4.18479698
11Abnormality of T cells (HP:0002843)4.16547716
12Fair hair (HP:0002286)4.09689690
13Dry hair (HP:0011359)4.05790564
14Recurrent fungal infections (HP:0002841)4.01704407
15Pustule (HP:0200039)3.85845680
16Myositis (HP:0100614)3.81238710
17Mesangial abnormality (HP:0001966)3.70242676
18IgG deficiency (HP:0004315)3.67178515
19Gastrointestinal infarctions (HP:0005244)3.54201281
20Generalized hypopigmentation of hair (HP:0011358)3.40976659
21Severe combined immunodeficiency (HP:0004430)3.33351563
22Papilledema (HP:0001085)3.32504014
23Asplenia (HP:0001746)3.06720146
24Joint swelling (HP:0001386)3.05525560
25IgA deficiency (HP:0002720)3.01897513
26Optic neuritis (HP:0100653)2.99679888
27Retrobulbar optic neuritis (HP:0100654)2.99679888
28Abnormality of the fingertips (HP:0001211)2.99653200
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.99470803
30Hemoptysis (HP:0002105)2.98225403
31Abnormality of the renal cortex (HP:0011035)2.91089139
32Chronic diarrhea (HP:0002028)2.91025837
33Eosinophilia (HP:0001880)2.88500740
34Abnormality of eosinophils (HP:0001879)2.88366012
35Increased IgM level (HP:0003496)2.83103186
36Spontaneous hematomas (HP:0007420)2.80921323
37Leukocytosis (HP:0001974)2.80217180
38Abnormality of T cell physiology (HP:0011840)2.80159963
39Granulocytopenia (HP:0001913)2.79329729
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.77879780
41Autoimmune hemolytic anemia (HP:0001890)2.76853166
42Orchitis (HP:0100796)2.73977843
43Thyroiditis (HP:0100646)2.72744823
44Stomach cancer (HP:0012126)2.64647262
45Autoimmune thrombocytopenia (HP:0001973)2.63236428
46Recurrent viral infections (HP:0004429)2.61082709
47Pulmonary infiltrates (HP:0002113)2.56719697
48Ridged nail (HP:0001807)2.56497382
49Chest pain (HP:0100749)2.54137052
50Keratoconjunctivitis (HP:0001096)2.50100182
51Abnormality of the prostate (HP:0008775)2.47928378
52Meningitis (HP:0001287)2.47747164
53Obstructive lung disease (HP:0006536)2.46807701
54Chronic obstructive pulmonary disease (HP:0006510)2.46807701
55Combined immunodeficiency (HP:0005387)2.46222931
56Lymphopenia (HP:0001888)2.40284996
57Hematochezia (HP:0002573)2.39120467
58Prolonged bleeding time (HP:0003010)2.37576511
59Hypoplasia of the thymus (HP:0000778)2.37228687
60IgM deficiency (HP:0002850)2.35365093
61Recurrent skin infections (HP:0001581)2.32664353
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.21375996
63Cheilitis (HP:0100825)2.19311165
64Eczematoid dermatitis (HP:0000976)2.17765255
65Abnormality of B cell number (HP:0010975)2.16865881
66Pulmonary embolism (HP:0002204)2.16842914
67Hypergammaglobulinemia (HP:0010702)2.15564630
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15219687
69Metaphyseal dysplasia (HP:0100255)2.14209230
70Woolly hair (HP:0002224)2.13528617
71Panhypogammaglobulinemia (HP:0003139)2.13421710
72Vasculitis (HP:0002633)2.13392757
73Recurrent bronchitis (HP:0002837)2.11639614
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.11520718
75Concave nail (HP:0001598)2.07737380
76Hypotrichosis (HP:0001006)2.07240451
77Microcytic anemia (HP:0001935)2.07183054
78Prominent nose (HP:0000448)2.06335743
79Epistaxis (HP:0000421)2.05164954
80Methylmalonic acidemia (HP:0002912)2.02401393
81Abnormality of macrophages (HP:0004311)1.95869815
82Prostate neoplasm (HP:0100787)1.94713752
83Hypochromic anemia (HP:0001931)1.94586600
84Tinnitus (HP:0000360)1.93782125
85Anorexia (HP:0002039)1.91979074
86Clumsiness (HP:0002312)1.89537238
87Keratoconjunctivitis sicca (HP:0001097)1.88003441
88Hyperlipoproteinemia (HP:0010980)1.86022959
89Mediastinal lymphadenopathy (HP:0100721)1.84791098
90Gingival bleeding (HP:0000225)1.84527568
91Increased IgE level (HP:0003212)1.84514905
92Increased cerebral lipofuscin (HP:0011813)1.84442805
93Recurrent abscess formation (HP:0002722)1.82395676
94Arterial thrombosis (HP:0004420)1.82382913
95Fatigue (HP:0012378)1.81139252
96Encephalitis (HP:0002383)1.78750238
97Polydipsia (HP:0001959)1.78378332
98Abnormal drinking behavior (HP:0030082)1.78378332
99Gangrene (HP:0100758)1.78338567
100Glomerulopathy (HP:0100820)1.77402938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.91998574
2TIE14.59846984
3RIPK13.01485768
4MAP2K23.00991044
5TGFBR22.99627914
6RIPK42.89160057
7MAP4K12.62687655
8GRK72.32417701
9STK102.25461178
10IKBKE2.23485830
11FES2.19037221
12CAMKK22.10550635
13TEC1.86682838
14MAP3K141.79436461
15MOS1.78248554
16KIT1.70584375
17CDK121.66609180
18FRK1.65767306
19GRK61.57689773
20EIF2AK21.56422005
21BRD41.55949290
22ITK1.55000120
23TLK11.53518306
24IKBKB1.51689111
25BMPR1B1.51197068
26JAK31.47685405
27TBK11.36318407
28SYK1.35502153
29LCK1.34107800
30CSK1.31991016
31CAMK1D1.30533253
32GRK11.29422683
33HCK1.13365677
34BTK1.13232384
35ZAP701.13219554
36BMX1.12666220
37GRK51.12216378
38MAP3K131.10426041
39MAP3K121.07665968
40TNK21.06050689
41FLT31.01829434
42TESK21.01324531
43NTRK20.99738461
44CAMKK10.99494377
45JAK10.96094159
46BLK0.95639211
47LYN0.95108574
48BMPR20.94319617
49FGFR20.92482091
50FGFR30.88268152
51JAK20.86038425
52ACVR1B0.85552242
53ERN10.84867314
54AKT30.79323378
55TYK20.76697791
56MAP3K70.75493071
57PIM10.71247261
58MAPK110.68998004
59CDK80.65710933
60PRKCQ0.64616974
61TRPM70.60068591
62MAP2K10.58289467
63ADRBK10.58135702
64KDR0.57266655
65DYRK1A0.56274585
66CDK90.55314488
67NEK60.53857674
68PRKD20.53555148
69TGFBR10.52735055
70TAOK30.51535852
71EIF2AK30.50685391
72NME10.50348875
73PDK10.49007464
74CSF1R0.47573566
75EGFR0.45732767
76IGF1R0.45527909
77FYN0.45215169
78MARK30.45019461
79PTK2B0.43627603
80MAPK120.42460323
81LMTK20.41847869
82MAPK70.40890311
83NUAK10.40577809
84MST40.40493807
85PRKAA20.40472726
86RPS6KA40.40055689
87IRAK40.37636796
88CDK60.36550002
89ABL10.35384537
90WNK10.33673075
91TYRO30.27919876
92CAMK1G0.27454713
93PASK0.25172847
94ADRBK20.24756677
95CDK40.24674947
96WNK40.22312801
97ERBB30.22247483
98EIF2AK10.21511871
99MAPK40.21450393
100INSR0.21199595

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.07690333
2Allograft rejection_Homo sapiens_hsa053303.75505615
3Graft-versus-host disease_Homo sapiens_hsa053323.40313953
4Autoimmune thyroid disease_Homo sapiens_hsa053203.07334540
5T cell receptor signaling pathway_Homo sapiens_hsa046602.97349019
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.85389747
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74286304
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.62815123
9Type I diabetes mellitus_Homo sapiens_hsa049402.57397869
10Leishmaniasis_Homo sapiens_hsa051402.48157485
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.38108103
12Measles_Homo sapiens_hsa051622.24960641
13Hematopoietic cell lineage_Homo sapiens_hsa046402.23982166
14Rheumatoid arthritis_Homo sapiens_hsa053232.23154736
15Asthma_Homo sapiens_hsa053102.10332670
16Antigen processing and presentation_Homo sapiens_hsa046122.03467928
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97470903
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.95921019
19Osteoclast differentiation_Homo sapiens_hsa043801.94378630
20Viral myocarditis_Homo sapiens_hsa054161.86473207
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80590589
22Malaria_Homo sapiens_hsa051441.68733136
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.65398735
24B cell receptor signaling pathway_Homo sapiens_hsa046621.64734044
25Herpes simplex infection_Homo sapiens_hsa051681.61741984
26Staphylococcus aureus infection_Homo sapiens_hsa051501.53125461
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47449097
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44276791
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41677342
30Tuberculosis_Homo sapiens_hsa051521.39888681
31African trypanosomiasis_Homo sapiens_hsa051431.38453360
32TNF signaling pathway_Homo sapiens_hsa046681.12488749
33Toxoplasmosis_Homo sapiens_hsa051451.10443608
34Influenza A_Homo sapiens_hsa051641.07753099
35Acute myeloid leukemia_Homo sapiens_hsa052211.07545272
36RNA polymerase_Homo sapiens_hsa030201.01247823
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00724841
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98889445
39Legionellosis_Homo sapiens_hsa051340.96535478
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96190731
41Chemokine signaling pathway_Homo sapiens_hsa040620.91086195
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.90485977
43ABC transporters_Homo sapiens_hsa020100.87973112
44Epstein-Barr virus infection_Homo sapiens_hsa051690.80551208
45HTLV-I infection_Homo sapiens_hsa051660.80375063
46Hepatitis B_Homo sapiens_hsa051610.70917357
47Caffeine metabolism_Homo sapiens_hsa002320.68861560
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67909308
49Regulation of autophagy_Homo sapiens_hsa041400.67816464
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67044382
51Platelet activation_Homo sapiens_hsa046110.66983178
52Apoptosis_Homo sapiens_hsa042100.66292673
53Glycerolipid metabolism_Homo sapiens_hsa005610.65075595
54Proteasome_Homo sapiens_hsa030500.58043734
55Non-small cell lung cancer_Homo sapiens_hsa052230.56721351
56Hepatitis C_Homo sapiens_hsa051600.56040793
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.55153829
58Renin secretion_Homo sapiens_hsa049240.53696299
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53489092
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52794885
61Salmonella infection_Homo sapiens_hsa051320.52357499
62N-Glycan biosynthesis_Homo sapiens_hsa005100.52008756
63Colorectal cancer_Homo sapiens_hsa052100.51740769
64Phagosome_Homo sapiens_hsa041450.50549544
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50214966
66Linoleic acid metabolism_Homo sapiens_hsa005910.47546670
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45826098
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44821428
69Endocytosis_Homo sapiens_hsa041440.44375712
70Phototransduction_Homo sapiens_hsa047440.43760720
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.41051216
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38446050
73Inositol phosphate metabolism_Homo sapiens_hsa005620.36557888
74Pancreatic cancer_Homo sapiens_hsa052120.36004465
75FoxO signaling pathway_Homo sapiens_hsa040680.34495031
76Endometrial cancer_Homo sapiens_hsa052130.34431415
77Systemic lupus erythematosus_Homo sapiens_hsa053220.33237792
78HIF-1 signaling pathway_Homo sapiens_hsa040660.32464231
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31751879
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30990888
81Lysosome_Homo sapiens_hsa041420.30779253
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30135528
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29907212
84Shigellosis_Homo sapiens_hsa051310.26604503
85Other glycan degradation_Homo sapiens_hsa005110.26097877
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25798025
87Pertussis_Homo sapiens_hsa051330.25785015
88VEGF signaling pathway_Homo sapiens_hsa043700.24826549
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20522656
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.20030002
91Arachidonic acid metabolism_Homo sapiens_hsa005900.18961884
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.18091112
93Dorso-ventral axis formation_Homo sapiens_hsa043200.17679363
94mTOR signaling pathway_Homo sapiens_hsa041500.16888280
95Nitrogen metabolism_Homo sapiens_hsa009100.15610369
96Insulin resistance_Homo sapiens_hsa049310.15081167
97Salivary secretion_Homo sapiens_hsa049700.14511161
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14084161
99Basal transcription factors_Homo sapiens_hsa030220.13807817
100Vitamin digestion and absorption_Homo sapiens_hsa049770.13449113

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