GIMAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.27975019
2negative thymic T cell selection (GO:0045060)8.14754497
3positive regulation of gamma-delta T cell activation (GO:0046645)7.83344165
4positive thymic T cell selection (GO:0045059)7.60820043
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.54186027
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.54186027
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.06138042
8negative regulation of cell killing (GO:0031342)7.06138042
9thymic T cell selection (GO:0045061)6.98160867
10regulation of isotype switching to IgG isotypes (GO:0048302)6.87639274
11positive T cell selection (GO:0043368)6.82991196
12antigen processing and presentation of endogenous antigen (GO:0019883)6.67955873
13regulation of gamma-delta T cell differentiation (GO:0045586)6.56359730
14response to interleukin-15 (GO:0070672)6.41911963
15interferon-gamma production (GO:0032609)6.36723738
16cellular response to interleukin-15 (GO:0071350)6.34038707
17T cell selection (GO:0045058)6.29791078
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.17253996
19T cell migration (GO:0072678)6.01328767
20regulation of gamma-delta T cell activation (GO:0046643)5.91189977
21leukocyte aggregation (GO:0070486)5.79394331
22regulation of T cell tolerance induction (GO:0002664)5.65175692
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.50838169
24regulation of B cell receptor signaling pathway (GO:0050855)5.39403884
25T cell costimulation (GO:0031295)5.30099818
26T cell receptor signaling pathway (GO:0050852)5.28298810
27lymphocyte costimulation (GO:0031294)5.24149681
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93978782
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.81762494
30regulation of alpha-beta T cell proliferation (GO:0046640)4.72610443
31antigen receptor-mediated signaling pathway (GO:0050851)4.68981330
32positive regulation of tolerance induction (GO:0002645)4.65646054
33regulation of natural killer cell mediated immunity (GO:0002715)4.62235468
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.62235468
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.54051516
36positive regulation by organism of defense response of other organism involved in symbiotic interact4.54051516
37modulation by symbiont of host immune response (GO:0052553)4.54051516
38positive regulation by symbiont of host defense response (GO:0052509)4.54051516
39modulation by symbiont of host defense response (GO:0052031)4.54051516
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.54051516
41positive regulation of natural killer cell mediated immunity (GO:0002717)4.45412128
42positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.45412128
43positive regulation of alpha-beta T cell proliferation (GO:0046641)4.42511496
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.40853346
45activated T cell proliferation (GO:0050798)4.38096736
46macrophage activation involved in immune response (GO:0002281)4.35934424
47positive regulation of isotype switching (GO:0045830)4.34556822
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.24474187
49detection of other organism (GO:0098543)4.16220113
50regulation of regulatory T cell differentiation (GO:0045589)4.10341094
51tolerance induction (GO:0002507)4.09201373
52regulation of tolerance induction (GO:0002643)4.07998848
53neutrophil activation involved in immune response (GO:0002283)4.05241095
54regulation of isotype switching (GO:0045191)4.04154059
55regulation of interleukin-2 biosynthetic process (GO:0045076)4.02449623
56sequestering of actin monomers (GO:0042989)4.00362496
57regulation of response to interferon-gamma (GO:0060330)3.99955317
58microglial cell activation (GO:0001774)3.99604120
59detection of bacterium (GO:0016045)3.97010729
60regulation of T cell receptor signaling pathway (GO:0050856)3.96762907
61regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.93845641
62positive regulation of interleukin-2 production (GO:0032743)3.91897415
63positive regulation of B cell mediated immunity (GO:0002714)3.89441493
64positive regulation of immunoglobulin mediated immune response (GO:0002891)3.89441493
65negative regulation of interleukin-12 production (GO:0032695)3.87005931
66leukocyte cell-cell adhesion (GO:0007159)3.84959560
67regulation of leukocyte mediated cytotoxicity (GO:0001910)3.81983841
68positive regulation of humoral immune response (GO:0002922)3.81598504
69regulation of T cell mediated cytotoxicity (GO:0001914)3.81127210
70negative regulation of leukocyte mediated immunity (GO:0002704)3.79627050
71regulation of interleukin-12 biosynthetic process (GO:0045075)3.77687852
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.76915575
73regulation of immunoglobulin mediated immune response (GO:0002889)3.75954501
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.75385171
75positive regulation of DNA recombination (GO:0045911)3.75151589
76antigen processing and presentation via MHC class Ib (GO:0002475)3.75025348
77negative regulation of T cell mediated immunity (GO:0002710)3.74755827
78regulation of type I interferon-mediated signaling pathway (GO:0060338)3.72040640
79B cell receptor signaling pathway (GO:0050853)3.71170393
80cellular extravasation (GO:0045123)3.67830926
81regulation of B cell differentiation (GO:0045577)3.67382818
82regulation of B cell mediated immunity (GO:0002712)3.66231516
83natural killer cell activation (GO:0030101)3.61469292
84detection of external biotic stimulus (GO:0098581)3.57808765
85respiratory burst (GO:0045730)3.57778499
86immunoglobulin mediated immune response (GO:0016064)3.55495833
87neutrophil activation (GO:0042119)3.54077714
88regulation of immunoglobulin production (GO:0002637)3.53238715
89regulation of cell killing (GO:0031341)3.50781340
90myeloid cell activation involved in immune response (GO:0002275)3.49020158
91positive regulation of immunoglobulin production (GO:0002639)3.48598920
92T cell differentiation (GO:0030217)3.47325718
93positive regulation of lamellipodium assembly (GO:0010592)3.44064894
94positive regulation of cell killing (GO:0031343)3.42845884
95dendritic cell chemotaxis (GO:0002407)3.42224335
96lymphocyte migration (GO:0072676)3.41650285
97detection of molecule of bacterial origin (GO:0032490)3.40198415
98immune response-activating cell surface receptor signaling pathway (GO:0002429)3.37845117
99mast cell activation (GO:0045576)3.37763219
100heterotypic cell-cell adhesion (GO:0034113)3.36749731
101negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.36054644
102regulation of interferon-beta biosynthetic process (GO:0045357)3.31093279
103positive regulation of B cell differentiation (GO:0045579)3.28753912
104T cell homeostasis (GO:0043029)3.28016269
105alpha-beta T cell activation (GO:0046631)3.27823137
106T cell activation (GO:0042110)3.27585420
107granulocyte activation (GO:0036230)3.26514103
108dendritic cell migration (GO:0036336)3.25790358
109negative regulation of lymphocyte mediated immunity (GO:0002707)3.25579091
110macrophage activation (GO:0042116)3.24682874
111response to type I interferon (GO:0034340)3.23326408
112regulation of defense response to virus by virus (GO:0050690)3.21505447
113negative regulation of T cell receptor signaling pathway (GO:0050860)3.20346446
114alpha-beta T cell differentiation (GO:0046632)3.19483841
115cytidine metabolic process (GO:0046087)3.16509072
116cytidine catabolic process (GO:0006216)3.16509072
117cytidine deamination (GO:0009972)3.16509072
118Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16494500
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15784506
120type I interferon signaling pathway (GO:0060337)3.15012210
121cellular response to type I interferon (GO:0071357)3.15012210
122positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.12838734
123detection of biotic stimulus (GO:0009595)3.10334385
124production of molecular mediator involved in inflammatory response (GO:0002532)3.09770018
125positive regulation of T cell activation (GO:0050870)3.09171968
126response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08242139
127response to host immune response (GO:0052572)3.08242139
128positive regulation of granulocyte differentiation (GO:0030854)3.07347741
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.04050842
130positive regulation of immune response to tumor cell (GO:0002839)3.03991241
131regulation of immune response to tumor cell (GO:0002837)3.03991241
132regulation of response to tumor cell (GO:0002834)3.03991241
133positive regulation of response to tumor cell (GO:0002836)3.03991241
134regulation of lymphocyte mediated immunity (GO:0002706)3.02664485
135cellular defense response (GO:0006968)3.02555163
136T cell proliferation (GO:0042098)3.01925681
137response to peptidoglycan (GO:0032494)3.00746779
138leukocyte degranulation (GO:0043299)2.98015036
139interferon-gamma-mediated signaling pathway (GO:0060333)2.97116467
140pyrimidine ribonucleoside catabolic process (GO:0046133)2.96881104
141positive regulation of lymphocyte mediated immunity (GO:0002708)2.95162644
142negative regulation of innate immune response (GO:0045824)2.94326241
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90781316
144neutrophil mediated immunity (GO:0002446)2.88560917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.20418997
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.46403991
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.49631355
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.18664735
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.04391022
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.00332727
7RUNX_20019798_ChIP-Seq_JUKART_Human3.93766586
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.69257253
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.64745246
10MYC_22102868_ChIP-Seq_BL_Human3.46221320
11* MYB_26560356_Chip-Seq_TH2_Human3.35286602
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12862328
13* MAF_26560356_Chip-Seq_TH1_Human3.11144017
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89409371
15* MYB_26560356_Chip-Seq_TH1_Human2.85197572
16* UTX_26944678_Chip-Seq_JUKART_Human2.76899769
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.65349976
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44080562
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40689782
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.21925930
21GATA3_27048872_Chip-Seq_THYMUS_Human2.16219861
22MAF_26560356_Chip-Seq_TH2_Human2.14794961
23VDR_21846776_ChIP-Seq_THP-1_Human2.12941172
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08159105
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05382654
26E2F7_22180533_ChIP-Seq_HELA_Human1.98576205
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98131327
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.97674044
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95252323
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93181637
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.90689427
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90206310
33TCF7_22412390_ChIP-Seq_EML_Mouse1.86883069
34* SPI1_23547873_ChIP-Seq_NB4_Human1.86572442
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.85989601
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79341480
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.78115032
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73731987
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73544383
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70291753
41SCL_19346495_ChIP-Seq_HPC-7_Human1.68072018
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66010606
43KDM2B_26808549_Chip-Seq_DND41_Human1.64410560
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.64283769
45VDR_24763502_ChIP-Seq_THP-1_Human1.60688671
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54671790
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54324979
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51154783
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50158927
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49003968
51SPI1_23127762_ChIP-Seq_K562_Human1.43903192
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40795604
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40599756
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38051964
55CIITA_25753668_ChIP-Seq_RAJI_Human1.37127447
56GATA3_26560356_Chip-Seq_TH2_Human1.33442068
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.30808497
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28350229
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22949664
60PU_27001747_Chip-Seq_BMDM_Mouse1.20746387
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19702138
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19227673
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14855983
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10543771
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.09891857
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08996205
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07771632
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07722056
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07261058
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06350625
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05691456
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04898643
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03477324
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02187013
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00028756
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97588648
77PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96555582
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94843263
79* BCL6_27268052_Chip-Seq_Bcells_Human0.93348458
80FOXP3_21729870_ChIP-Seq_TREG_Human0.93184529
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92222427
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91860517
83VDR_23849224_ChIP-Seq_CD4+_Human0.91107789
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90481808
85ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90094305
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90034662
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89331353
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85900977
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85180236
90NCOR1_26117541_ChIP-Seq_K562_Human0.84909777
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84354406
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82958676
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82397214
94GATA1_22025678_ChIP-Seq_K562_Human0.81285384
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79183772
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.78814102
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77095979
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76945615
99* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75872476
100SMRT_27268052_Chip-Seq_Bcells_Human0.75182972
101SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.74759042
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74455264
103BCOR_27268052_Chip-Seq_Bcells_Human0.74212441
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73962298
105SPI1_20517297_ChIP-Seq_HL60_Human0.73585405
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73331277
107GATA3_26560356_Chip-Seq_TH1_Human0.71839982
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70924006
109LXR_22292898_ChIP-Seq_THP-1_Human0.70065268
110* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69934975
111GATA1_19941826_ChIP-Seq_K562_Human0.66805178
112GATA2_19941826_ChIP-Seq_K562_Human0.66053671
113ELK1_19687146_ChIP-ChIP_HELA_Human0.65253823
114FOXM1_23109430_ChIP-Seq_U2OS_Human0.63182817
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.61544525
116* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.60529614
117VDR_24787735_ChIP-Seq_THP-1_Human0.59984449
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.59022428
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.58839570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.33831134
2MP0005671_abnormal_response_to5.06911923
3MP0001835_abnormal_antigen_presentation3.81259406
4MP0000685_abnormal_immune_system3.78522220
5MP0001800_abnormal_humoral_immune3.44147031
6MP0005387_immune_system_phenotype3.26324189
7MP0001790_abnormal_immune_system3.26324189
8MP0002166_altered_tumor_susceptibility3.10174376
9* MP0002420_abnormal_adaptive_immunity2.97016563
10MP0006082_CNS_inflammation2.96849837
11* MP0001819_abnormal_immune_cell2.91880431
12MP0005000_abnormal_immune_tolerance2.91880358
13MP0009785_altered_susceptibility_to2.91562764
14MP0002723_abnormal_immune_serum2.90061660
15MP0002398_abnormal_bone_marrow2.85702733
16MP0009333_abnormal_splenocyte_physiolog2.76954590
17MP0002452_abnormal_antigen_presenting2.72422564
18MP0005025_abnormal_response_to2.61255107
19MP0003724_increased_susceptibility_to2.59805175
20MP0000716_abnormal_immune_system2.52459293
21MP0002006_tumorigenesis2.51388501
22MP0000703_abnormal_thymus_morphology2.43479752
23MP0002405_respiratory_system_inflammati2.40071636
24MP0003300_gastrointestinal_ulcer2.33947166
25MP0002722_abnormal_immune_system2.30969203
26MP0000689_abnormal_spleen_morphology2.27436249
27MP0001873_stomach_inflammation2.26183536
28MP0003866_abnormal_defecation2.20824998
29MP0004947_skin_inflammation2.16224841
30MP0010155_abnormal_intestine_physiology2.13861808
31MP0002396_abnormal_hematopoietic_system2.12748819
32MP0002429_abnormal_blood_cell2.05277160
33MP0003436_decreased_susceptibility_to2.04128177
34MP0002933_joint_inflammation1.87839181
35MP0002419_abnormal_innate_immunity1.81627994
36MP0002148_abnormal_hypersensitivity_rea1.79251798
37MP0001845_abnormal_inflammatory_respons1.70184938
38MP0005464_abnormal_platelet_physiology1.65307176
39MP0008260_abnormal_autophagy1.63384578
40MP0004510_myositis1.62211487
41MP0003303_peritoneal_inflammation1.62198733
42MP0000858_altered_metastatic_potential1.61519145
43MP0001853_heart_inflammation1.56463926
44MP0003690_abnormal_glial_cell1.54656708
45MP0004883_abnormal_blood_vessel1.53180689
46MP0003448_altered_tumor_morphology1.50705841
47MP0002277_abnormal_respiratory_mucosa1.35845630
48MP0004808_abnormal_hematopoietic_stem1.29217428
49MP0003045_fibrosis1.26055672
50MP0008469_abnormal_protein_level1.25019003
51MP0005310_abnormal_salivary_gland1.13479192
52MP0001851_eye_inflammation1.12070929
53MP0000465_gastrointestinal_hemorrhage1.09241253
54MP0005164_abnormal_response_to1.08257015
55MP0010352_gastrointestinal_tract_polyps1.07808737
56MP0002009_preneoplasia1.06959153
57MP0002019_abnormal_tumor_incidence1.04690062
58MP0001533_abnormal_skeleton_physiology1.02617882
59MP0003172_abnormal_lysosome_physiology1.01249061
60MP0002138_abnormal_hepatobiliary_system1.00972613
61MP0003183_abnormal_peptide_metabolism0.96797217
62MP0002132_abnormal_respiratory_system0.95960513
63MP0004381_abnormal_hair_follicle0.91981823
64MP0003075_altered_response_to0.91440746
65MP0005023_abnormal_wound_healing0.90689429
66MP0004130_abnormal_muscle_cell0.88051590
67MP0009763_increased_sensitivity_to0.87732317
68MP0002998_abnormal_bone_remodeling0.87094514
69MP0000490_abnormal_crypts_of0.86216383
70MP0005397_hematopoietic_system_phenotyp0.73317819
71MP0001545_abnormal_hematopoietic_system0.73317819
72MP0003828_pulmonary_edema0.72634290
73MP0002136_abnormal_kidney_physiology0.71621268
74MP0008961_abnormal_basal_metabolism0.71561742
75MP0005075_abnormal_melanosome_morpholog0.70840876
76MP0010368_abnormal_lymphatic_system0.69130053
77MP0005390_skeleton_phenotype0.69077817
78MP0009764_decreased_sensitivity_to0.67382190
79MP0006054_spinal_hemorrhage0.66509949
80MP0001879_abnormal_lymphatic_vessel0.65903230
81MP0000609_abnormal_liver_physiology0.65164656
82MP0009765_abnormal_xenobiotic_induced0.62776163
83MP0008004_abnormal_stomach_pH0.62596517
84MP0002254_reproductive_system_inflammat0.62325310
85MP0000249_abnormal_blood_vessel0.61278664
86MP0000477_abnormal_intestine_morphology0.59745609
87MP0001986_abnormal_taste_sensitivity0.58959405
88MP0001191_abnormal_skin_condition0.58125819
89MP0004484_altered_response_of0.57463016
90MP0000920_abnormal_myelination0.57010997
91MP0003453_abnormal_keratinocyte_physiol0.56898258
92MP0002822_catalepsy0.55924712
93MP0001348_abnormal_lacrimal_gland0.55437045
94MP0003091_abnormal_cell_migration0.54700628
95MP0005166_decreased_susceptibility_to0.54273839
96MP0008874_decreased_physiological_sensi0.53454044
97MP0005167_abnormal_blood-brain_barrier0.53234350
98MP0003077_abnormal_cell_cycle0.50756712
99MP0003795_abnormal_bone_structure0.50579350
100MP0000569_abnormal_digit_pigmentation0.49331777
101MP0005076_abnormal_cell_differentiation0.48873447
102MP0010234_abnormal_vibrissa_follicle0.48402289
103MP0009278_abnormal_bone_marrow0.47214347
104MP0000343_altered_response_to0.46531286
105MP0008873_increased_physiological_sensi0.46114810
106MP0000604_amyloidosis0.45855509
107MP0001243_abnormal_dermal_layer0.44815440
108MP0005381_digestive/alimentary_phenotyp0.44003954
109MP0003279_aneurysm0.43917006
110MP0009643_abnormal_urine_homeostasis0.43613368
111MP0005388_respiratory_system_phenotype0.42667155
112MP0002133_abnormal_respiratory_system0.42667155
113MP0003943_abnormal_hepatobiliary_system0.42399740
114MP0008057_abnormal_DNA_replication0.41998129
115MP0003252_abnormal_bile_duct0.41706315
116MP0003566_abnormal_cell_adhesion0.41546816
117MP0000598_abnormal_liver_morphology0.40339160
118MP0002693_abnormal_pancreas_physiology0.38975250
119MP0002168_other_aberrant_phenotype0.38248337
120MP0001663_abnormal_digestive_system0.38199085
121MP0001216_abnormal_epidermal_layer0.35303225
122MP0003191_abnormal_cellular_cholesterol0.34951114
123MP0005451_abnormal_body_composition0.33730964

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.13656881
2Abnormality of T cell number (HP:0011839)6.92015471
3Recurrent bronchitis (HP:0002837)5.77972697
4Abnormality of T cells (HP:0002843)5.42128129
5Nasal polyposis (HP:0100582)5.21333090
6Elevated erythrocyte sedimentation rate (HP:0003565)5.12343770
7Severe combined immunodeficiency (HP:0004430)5.03480701
8Chronic otitis media (HP:0000389)5.02629859
9Stomatitis (HP:0010280)4.92672262
10Abnormality of macrophages (HP:0004311)4.87309609
11IgM deficiency (HP:0002850)4.85238229
12Abnormality of the nasal mucosa (HP:0000433)4.82921896
13Combined immunodeficiency (HP:0005387)4.82673102
14IgG deficiency (HP:0004315)4.64460985
15Recurrent gram-negative bacterial infections (HP:0005420)4.24090043
16Recurrent fungal infections (HP:0002841)4.23081023
17Panhypogammaglobulinemia (HP:0003139)4.21218816
18Recurrent viral infections (HP:0004429)4.21070200
19Increased IgM level (HP:0003496)4.15667109
20Myositis (HP:0100614)4.07907849
21Lymphopenia (HP:0001888)3.92803467
22Recurrent cutaneous fungal infections (HP:0011370)3.92208216
23Chronic mucocutaneous candidiasis (HP:0002728)3.92208216
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.89929073
25Abnormality of T cell physiology (HP:0011840)3.88095170
26Eczematoid dermatitis (HP:0000976)3.83199001
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.77839845
28Abnormality of the fingertips (HP:0001211)3.72009044
29Autoimmune hemolytic anemia (HP:0001890)3.70680623
30Chronic diarrhea (HP:0002028)3.58297127
31Pustule (HP:0200039)3.57112097
32Joint swelling (HP:0001386)3.54078928
33Agammaglobulinemia (HP:0004432)3.51128076
34Spontaneous hematomas (HP:0007420)3.44835178
35Abnormality of eosinophils (HP:0001879)3.43110578
36Meningitis (HP:0001287)3.37314737
37Recurrent sinusitis (HP:0011108)3.35764039
38Bronchitis (HP:0012387)3.33390114
39IgA deficiency (HP:0002720)3.33063213
40Thyroiditis (HP:0100646)3.24894567
41Vasculitis (HP:0002633)3.21244767
42Encephalitis (HP:0002383)3.17852578
43Abnormality of B cell number (HP:0010975)3.17479795
44B lymphocytopenia (HP:0010976)3.17479795
45Inflammation of the large intestine (HP:0002037)3.13077319
46Retrobulbar optic neuritis (HP:0100654)3.12002175
47Optic neuritis (HP:0100653)3.12002175
48Eosinophilia (HP:0001880)3.11596895
49Hemoptysis (HP:0002105)3.10617628
50Leukocytosis (HP:0001974)3.07825132
51Gastrointestinal inflammation (HP:0004386)3.05747985
52Chronic sinusitis (HP:0011109)3.04442459
53Autoimmune thrombocytopenia (HP:0001973)2.97216448
54Urticaria (HP:0001025)2.89889146
55Hypochromic anemia (HP:0001931)2.84705701
56Orchitis (HP:0100796)2.84372418
57Gastrointestinal infarctions (HP:0005244)2.84308948
58Recurrent abscess formation (HP:0002722)2.81893874
59Gingival bleeding (HP:0000225)2.78574402
60Granulocytopenia (HP:0001913)2.77260938
61Hypergammaglobulinemia (HP:0010702)2.75252530
62Pulmonary infiltrates (HP:0002113)2.74932388
63Papilloma (HP:0012740)2.73476197
64Verrucae (HP:0200043)2.73476197
65Hypochromic microcytic anemia (HP:0004840)2.64860140
66Lymphoma (HP:0002665)2.64113642
67Colitis (HP:0002583)2.63462480
68Recurrent otitis media (HP:0000403)2.56852252
69Basal cell carcinoma (HP:0002671)2.56180861
70Mediastinal lymphadenopathy (HP:0100721)2.54786228
71Gastrointestinal stroma tumor (HP:0100723)2.50504570
72Pulmonary embolism (HP:0002204)2.49987882
73Recurrent skin infections (HP:0001581)2.47239329
74Episodic fever (HP:0001954)2.46930622
75Arterial thrombosis (HP:0004420)2.46058436
76Keratoconjunctivitis sicca (HP:0001097)2.45980538
77Hemiplegia (HP:0002301)2.44582792
78Emphysema (HP:0002097)2.43537390
79Chronic obstructive pulmonary disease (HP:0006510)2.40808337
80Obstructive lung disease (HP:0006536)2.40808337
81Increased IgE level (HP:0003212)2.38507645
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34308517
83Stomach cancer (HP:0012126)2.31584360
84Peritonitis (HP:0002586)2.28798671
85Chest pain (HP:0100749)2.27533408
86Hypoplasia of the thymus (HP:0000778)2.26933406
87Thrombocytosis (HP:0001894)2.26155175
88Abnormality of the pleura (HP:0002103)2.25861155
89Epistaxis (HP:0000421)2.22818809
90Hepatitis (HP:0012115)2.21581115
91Acute hepatic failure (HP:0006554)2.21423830
92Keratoconjunctivitis (HP:0001096)2.20373363
93Sepsis (HP:0100806)2.15503174
94Hypoproteinemia (HP:0003075)2.13923960
95Ureteral stenosis (HP:0000071)2.13288704
96Osteomyelitis (HP:0002754)2.12421127
97Hematochezia (HP:0002573)2.12403732
98Purpura (HP:0000979)2.11832791
99Petechiae (HP:0000967)2.09748523
100Abnormal platelet volume (HP:0011876)2.08915526
101Keratitis (HP:0000491)2.07506647
102Glomerulopathy (HP:0100820)2.07091368
103Prolonged bleeding time (HP:0003010)2.03457925
104Vertigo (HP:0002321)1.98397841
105Skin ulcer (HP:0200042)1.96833824
106Microcytic anemia (HP:0001935)1.96438945
107Bronchiectasis (HP:0002110)1.95114632
108Cheilitis (HP:0100825)1.93135881
109Ureteral obstruction (HP:0006000)1.93073014
110Abnormality of the prostate (HP:0008775)1.91990773
111Gingivitis (HP:0000230)1.91427164
112Abnormality of the peritoneum (HP:0002585)1.91267220
113Recurrent bacterial skin infections (HP:0005406)1.90458930
114Papilledema (HP:0001085)1.90235678
115Cellulitis (HP:0100658)1.88942343
116Gangrene (HP:0100758)1.87169671
117Acne (HP:0001061)1.86622388
118Increased density of long bones (HP:0006392)1.85687041
119Amaurosis fugax (HP:0100576)1.84422532
120Arthralgia (HP:0002829)1.78350124
121Restrictive lung disease (HP:0002091)1.75309333
122Anorexia (HP:0002039)1.75188028
123Abnormality of the endocardium (HP:0004306)1.74810588
124Skin rash (HP:0000988)1.74002277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.04568203
2MAP4K15.83222803
3RIPK43.85038935
4FGFR43.54139073
5ITK3.38665102
6JAK33.30300856
7ZAP702.93375534
8TYK22.80329510
9IKBKE2.80004942
10STK102.75307845
11KDR2.63570969
12JAK12.61362061
13FGFR32.20320424
14GRK62.12979321
15TAOK32.05242929
16LCK1.95317663
17MAP3K141.89090494
18TBK11.73710334
19FGR1.72795756
20NLK1.70468974
21CSK1.67948826
22TEC1.64914743
23PRPF4B1.60106443
24TESK21.55069149
25MAP3K111.48931858
26PRKCH1.44471771
27BTK1.41191477
28MST41.39427113
29PRKCQ1.38260012
30SYK1.37797981
31MAP3K101.36798170
32BLK1.35651785
33MAP3K131.33693163
34LRRK21.32796358
35KIT1.31884052
36TGFBR21.28644454
37HCK1.27176726
38MARK31.22090285
39MAP3K31.16917412
40SIK21.15436771
41PKN21.07905713
42CAMKK21.06959195
43PIK3CG1.01540020
44CLK10.99175169
45CAMKK10.96686210
46MAP3K120.95780846
47IKBKB0.92923530
48EEF2K0.90513846
49JAK20.90274904
50IRAK40.90114757
51FES0.89199054
52MAP3K10.87595064
53PIM10.84325740
54GRK70.83924076
55BMPR20.83664812
56LYN0.83444840
57YES10.81117299
58SIK30.80555600
59TTN0.75579069
60EPHB10.75366329
61TIE10.71652277
62CSF1R0.70947271
63RPS6KA40.69529889
64EPHA30.68168349
65TGFBR10.67368488
66PTK2B0.66684682
67TYRO30.64727571
68NME20.64391191
69TNK20.63645181
70MATK0.63542693
71MAP3K70.62264056
72TRIB30.61458079
73ERN10.54841770
74CHUK0.53924743
75PDK10.51843732
76MAPK110.50569555
77MAPK120.49330730
78MAPK70.49303901
79INSR0.48515828
80PDPK10.48231503
81IGF1R0.48147520
82CDK40.48053510
83MAP2K30.47723045
84KSR20.47326661
85MELK0.46809939
86FGFR10.46722167
87PDGFRB0.46487534
88PRKD20.45948771
89SGK30.43611058
90FYN0.42547036
91CDK120.42478806
92PTK60.42125545
93DMPK0.42045577
94STK110.41240815
95SGK20.40829498
96MAP2K60.39838520
97GRK50.39756297
98MAP3K50.37718724
99MARK20.37567686
100TAOK20.37540554
101DYRK1B0.36841483
102SIK10.35767469
103MAP3K20.35683408
104FLT30.35297488
105HIPK20.34318569
106CDC42BPA0.34295882
107ALK0.33994703
108MAPKAPK20.31278962
109FGFR20.30353508
110MYLK0.29879609
111STK40.27571001
112TAOK10.26449814
113RET0.25659687
114IRAK20.25633277
115CDK90.25599534
116TESK10.25464992
117CDK190.24908250
118PRKD10.24705352
119IRAK10.24566779
120STK380.23683523
121STK240.22799859
122EGFR0.20762365
123MAP3K80.20675399
124MAPK30.20229310
125ABL10.20091448
126PASK0.19160049
127MAPK40.18716398
128RAF10.17771535
129NUAK10.17705923
130RIPK10.17209490
131SRC0.17152040
132CDK60.16364615

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.15311401
2T cell receptor signaling pathway_Homo sapiens_hsa046603.75652641
3Graft-versus-host disease_Homo sapiens_hsa053323.62767646
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.52090940
5Allograft rejection_Homo sapiens_hsa053303.21693584
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.00005164
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.96651956
8Antigen processing and presentation_Homo sapiens_hsa046122.87321593
9Measles_Homo sapiens_hsa051622.80614556
10Autoimmune thyroid disease_Homo sapiens_hsa053202.51562101
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.49122864
12Viral myocarditis_Homo sapiens_hsa054162.49019144
13Hematopoietic cell lineage_Homo sapiens_hsa046402.23146934
14B cell receptor signaling pathway_Homo sapiens_hsa046622.10110818
15Leishmaniasis_Homo sapiens_hsa051401.83529186
16Osteoclast differentiation_Homo sapiens_hsa043801.79132534
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.71282216
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58333611
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.55637309
20Herpes simplex infection_Homo sapiens_hsa051681.49633564
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43781284
22Toxoplasmosis_Homo sapiens_hsa051451.40129379
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37844582
24Chemokine signaling pathway_Homo sapiens_hsa040621.32765045
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32255263
26Type I diabetes mellitus_Homo sapiens_hsa049401.24851787
27Hepatitis B_Homo sapiens_hsa051611.21371505
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20745417
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19498547
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12638556
31Shigellosis_Homo sapiens_hsa051311.12342886
32Malaria_Homo sapiens_hsa051441.09488901
33Pancreatic cancer_Homo sapiens_hsa052121.08046276
34Asthma_Homo sapiens_hsa053101.06017955
35Phagosome_Homo sapiens_hsa041451.05281453
36HTLV-I infection_Homo sapiens_hsa051661.05108663
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04450430
38Acute myeloid leukemia_Homo sapiens_hsa052211.04027274
39Apoptosis_Homo sapiens_hsa042101.03721674
40Influenza A_Homo sapiens_hsa051641.03614830
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02332474
42Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97642914
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94774161
44TNF signaling pathway_Homo sapiens_hsa046680.94621406
45Platelet activation_Homo sapiens_hsa046110.94005495
46VEGF signaling pathway_Homo sapiens_hsa043700.89485891
47Staphylococcus aureus infection_Homo sapiens_hsa051500.83658755
48Hepatitis C_Homo sapiens_hsa051600.83019239
49Ribosome_Homo sapiens_hsa030100.78907598
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78871368
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77582269
52Colorectal cancer_Homo sapiens_hsa052100.77260517
53Epstein-Barr virus infection_Homo sapiens_hsa051690.75494372
54Chronic myeloid leukemia_Homo sapiens_hsa052200.67066410
55Legionellosis_Homo sapiens_hsa051340.66561123
56Tuberculosis_Homo sapiens_hsa051520.66165356
57Prolactin signaling pathway_Homo sapiens_hsa049170.63418435
58Viral carcinogenesis_Homo sapiens_hsa052030.63015612
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58426986
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57255438
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56390729
62Dorso-ventral axis formation_Homo sapiens_hsa043200.56186489
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55229811
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54327208
65Salmonella infection_Homo sapiens_hsa051320.54141856
66Small cell lung cancer_Homo sapiens_hsa052220.54136997
67p53 signaling pathway_Homo sapiens_hsa041150.53913405
68Regulation of autophagy_Homo sapiens_hsa041400.53074628
69Pertussis_Homo sapiens_hsa051330.52797404
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52128552
71Endocytosis_Homo sapiens_hsa041440.50761633
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47544332
73Non-small cell lung cancer_Homo sapiens_hsa052230.46943463
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45768239
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45293319
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45240043
77Rap1 signaling pathway_Homo sapiens_hsa040150.45209805
78Other glycan degradation_Homo sapiens_hsa005110.44616046
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.44245159
80Notch signaling pathway_Homo sapiens_hsa043300.44173357
81Spliceosome_Homo sapiens_hsa030400.42488793
82Insulin resistance_Homo sapiens_hsa049310.37676358
83FoxO signaling pathway_Homo sapiens_hsa040680.36449557
84Adherens junction_Homo sapiens_hsa045200.35579213
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34519741
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34232197
87Caffeine metabolism_Homo sapiens_hsa002320.33454100
88Amoebiasis_Homo sapiens_hsa051460.33072559
89Focal adhesion_Homo sapiens_hsa045100.31343030
90Lysosome_Homo sapiens_hsa041420.31316659
91Rheumatoid arthritis_Homo sapiens_hsa053230.31283852
92Renal cell carcinoma_Homo sapiens_hsa052110.30493730
93MAPK signaling pathway_Homo sapiens_hsa040100.29893484
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.29241012
95Base excision repair_Homo sapiens_hsa034100.28782571
96Inositol phosphate metabolism_Homo sapiens_hsa005620.27849197
97GnRH signaling pathway_Homo sapiens_hsa049120.27071177
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26380198
99Complement and coagulation cascades_Homo sapiens_hsa046100.25483211
100Type II diabetes mellitus_Homo sapiens_hsa049300.24655120
101Long-term potentiation_Homo sapiens_hsa047200.24498425
102mTOR signaling pathway_Homo sapiens_hsa041500.24127346
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22828132
104Pathways in cancer_Homo sapiens_hsa052000.22643973
105RNA degradation_Homo sapiens_hsa030180.22610918
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.21668148
107Non-homologous end-joining_Homo sapiens_hsa034500.20099530
108Choline metabolism in cancer_Homo sapiens_hsa052310.19832303
109ABC transporters_Homo sapiens_hsa020100.19147091
110HIF-1 signaling pathway_Homo sapiens_hsa040660.18177255
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17958008
112Prostate cancer_Homo sapiens_hsa052150.17736579
113Proteoglycans in cancer_Homo sapiens_hsa052050.15647678
114African trypanosomiasis_Homo sapiens_hsa051430.14529563
115Ras signaling pathway_Homo sapiens_hsa040140.12422876
116Endometrial cancer_Homo sapiens_hsa052130.12052731
117mRNA surveillance pathway_Homo sapiens_hsa030150.11958509
118Thyroid cancer_Homo sapiens_hsa052160.11584996
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.08895063

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