GIMAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.32205512
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.32205512
3* positive regulation of gamma-delta T cell activation (GO:0046645)5.77286793
4antigen processing and presentation of endogenous antigen (GO:0019883)5.67642084
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.54169752
6negative T cell selection (GO:0043383)5.46243936
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45413558
8positive thymic T cell selection (GO:0045059)5.43478906
9negative thymic T cell selection (GO:0045060)5.35344140
10ribosomal small subunit assembly (GO:0000028)5.05533498
11* regulation of gamma-delta T cell differentiation (GO:0045586)4.99821099
12response to interleukin-15 (GO:0070672)4.96556450
13interferon-gamma production (GO:0032609)4.86964073
14cellular response to interleukin-15 (GO:0071350)4.81131680
15positive T cell selection (GO:0043368)4.62686224
16thymic T cell selection (GO:0045061)4.59619637
17regulation of B cell receptor signaling pathway (GO:0050855)4.50519884
18regulation of isotype switching to IgG isotypes (GO:0048302)4.46941629
19antigen processing and presentation via MHC class Ib (GO:0002475)4.46227531
20* regulation of gamma-delta T cell activation (GO:0046643)4.42137786
21regulation of interleukin-12 biosynthetic process (GO:0045075)4.38276166
22negative regulation of T cell mediated immunity (GO:0002710)4.33594453
23tolerance induction (GO:0002507)4.23512671
24activated T cell proliferation (GO:0050798)4.21778365
25T cell selection (GO:0045058)4.21610546
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.19885020
27T cell migration (GO:0072678)4.11646023
28leukocyte aggregation (GO:0070486)3.99225618
29viral transcription (GO:0019083)3.93185991
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.84631774
31T cell receptor signaling pathway (GO:0050852)3.84373041
32positive regulation of tolerance induction (GO:0002645)3.84236401
33detection of other organism (GO:0098543)3.80901794
34response to type I interferon (GO:0034340)3.80054474
35mast cell activation (GO:0045576)3.77013170
36detection of bacterium (GO:0016045)3.76625715
37antigen receptor-mediated signaling pathway (GO:0050851)3.75346869
38mature B cell differentiation (GO:0002335)3.74552009
39response to interferon-beta (GO:0035456)3.74127202
40modulation by symbiont of host immune response (GO:0052553)3.73832524
41positive regulation by symbiont of host defense response (GO:0052509)3.73832524
42modulation by symbiont of host defense response (GO:0052031)3.73832524
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73832524
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73832524
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.73832524
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73817014
47translational termination (GO:0006415)3.72454427
48type I interferon signaling pathway (GO:0060337)3.72150412
49cellular response to type I interferon (GO:0071357)3.72150412
50negative regulation of leukocyte mediated immunity (GO:0002704)3.70103388
51mature B cell differentiation involved in immune response (GO:0002313)3.69185615
52negative regulation of interleukin-12 production (GO:0032695)3.68177147
53B cell receptor signaling pathway (GO:0050853)3.66808112
54negative regulation of cell killing (GO:0031342)3.66482372
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.66482372
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.63677961
57megakaryocyte development (GO:0035855)3.63034571
58regulation of B cell differentiation (GO:0045577)3.61903174
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.60350673
60definitive hemopoiesis (GO:0060216)3.58318474
61regulation of alpha-beta T cell proliferation (GO:0046640)3.57216693
62T cell costimulation (GO:0031295)3.53403091
63regulation of T cell receptor signaling pathway (GO:0050856)3.52946295
64lymphocyte costimulation (GO:0031294)3.52451657
65regulation of response to interferon-gamma (GO:0060330)3.50929222
66positive regulation of B cell differentiation (GO:0045579)3.50693294
67defense response to protozoan (GO:0042832)3.49522111
68negative regulation of erythrocyte differentiation (GO:0045647)3.47766709
69response to protozoan (GO:0001562)3.47535057
70regulation of T cell tolerance induction (GO:0002664)3.45533361
71lymph node development (GO:0048535)3.43753761
72positive regulation of isotype switching (GO:0045830)3.42022009
73regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.42003941
74neutrophil activation involved in immune response (GO:0002283)3.39337086
75regulation of tolerance induction (GO:0002643)3.37363995
76dendritic cell chemotaxis (GO:0002407)3.33333522
77immunoglobulin mediated immune response (GO:0016064)3.32892218
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.28052775
79cellular extravasation (GO:0045123)3.27413470
80positive regulation of granulocyte differentiation (GO:0030854)3.25809809
81CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.25272925
82natural killer cell activation (GO:0030101)3.24778673
83translational elongation (GO:0006414)3.24756898
84macrophage activation involved in immune response (GO:0002281)3.22579805
85Peyers patch development (GO:0048541)3.21257193
86mucosal-associated lymphoid tissue development (GO:0048537)3.21257193
87ribosomal small subunit biogenesis (GO:0042274)3.21145871
88interferon-gamma-mediated signaling pathway (GO:0060333)3.18322828
89regulation of type I interferon-mediated signaling pathway (GO:0060338)3.17591937
90positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17183179
91* T cell differentiation (GO:0030217)3.16135289
92dendritic cell migration (GO:0036336)3.14332385
93positive regulation of DNA recombination (GO:0045911)3.11976379
94negative regulation of innate immune response (GO:0045824)3.11311213
95* regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11007604
96detection of external biotic stimulus (GO:0098581)3.10944158
97lymphocyte migration (GO:0072676)3.10847803
98positive regulation of interleukin-2 production (GO:0032743)3.10502947
99* regulation of cell killing (GO:0031341)3.09932507
100Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09687071
101positive regulation of immunoglobulin production (GO:0002639)3.08833481
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08681686
103* regulation of regulatory T cell differentiation (GO:0045589)3.08255744
104positive regulation of T cell mediated cytotoxicity (GO:0001916)3.07038828
105NIK/NF-kappaB signaling (GO:0038061)3.06107535
106neutrophil activation (GO:0042119)3.04651520
107alpha-beta T cell activation (GO:0046631)3.01460787
108* T cell homeostasis (GO:0043029)3.01130006
109alpha-beta T cell differentiation (GO:0046632)3.00888722
110germinal center formation (GO:0002467)2.99754967
111cotranslational protein targeting to membrane (GO:0006613)2.99703331
112regulation of T cell mediated cytotoxicity (GO:0001914)2.99413156
113negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99290592
114respiratory burst (GO:0045730)2.99254881
115protein targeting to ER (GO:0045047)2.99223987
116regulation of isotype switching (GO:0045191)2.98927025
117mast cell activation involved in immune response (GO:0002279)2.97305246
118mast cell degranulation (GO:0043303)2.97305246
119nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95837719
120cellular response to interferon-beta (GO:0035458)2.95522057
121lymphocyte chemotaxis (GO:0048247)2.94732429
122negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94330195
123viral life cycle (GO:0019058)2.93138496
124regulation of T cell mediated immunity (GO:0002709)2.92665981
125myeloid cell activation involved in immune response (GO:0002275)2.91895396
126* regulation of leukocyte mediated cytotoxicity (GO:0001910)2.91819582
127* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.91734676
128leukocyte cell-cell adhesion (GO:0007159)2.89857778
129* positive regulation of cell killing (GO:0031343)2.89808687
130* T cell activation (GO:0042110)2.89372194
131regulation of interferon-beta biosynthetic process (GO:0045357)2.85284925
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84211203
133granulocyte activation (GO:0036230)2.84002552
134* regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83988759
135* regulation of natural killer cell mediated immunity (GO:0002715)2.83988759
136negative regulation of adaptive immune response (GO:0002820)2.83346735
137protein localization to endoplasmic reticulum (GO:0070972)2.83204591
138regulation of immunoglobulin production (GO:0002637)2.83165663
139* regulation of alpha-beta T cell activation (GO:0046634)2.80352447
140cytidine catabolic process (GO:0006216)2.80132429
141cytidine deamination (GO:0009972)2.80132429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.72479197
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.90595066
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.52790505
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.10908667
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49731455
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.47457809
7SCL_19346495_ChIP-Seq_HPC-7_Human3.39587287
8MYC_22102868_ChIP-Seq_BL_Human3.32993388
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.12880280
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.10436446
11RUNX_20019798_ChIP-Seq_JUKART_Human3.07995917
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.96336140
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.93875155
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.93440025
15MYB_26560356_Chip-Seq_TH2_Human2.82465764
16* NOTCH1_21737748_ChIP-Seq_TLL_Human2.77917824
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.76751536
18* MAF_26560356_Chip-Seq_TH1_Human2.61863682
19MYB_26560356_Chip-Seq_TH1_Human2.50338651
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.46681341
21E2F7_22180533_ChIP-Seq_HELA_Human2.39444085
22UTX_26944678_Chip-Seq_JUKART_Human2.39311127
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37965825
24* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.35618446
25VDR_21846776_ChIP-Seq_THP-1_Human2.34296861
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.24859314
27* SPI1_23547873_ChIP-Seq_NB4_Human2.23146945
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.22403820
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06920536
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.03691285
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.99665187
32TCF7_22412390_ChIP-Seq_EML_Mouse1.94623393
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88950773
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.87396898
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85301805
36MAF_26560356_Chip-Seq_TH2_Human1.83783731
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82999377
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81896181
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80793300
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80137342
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.78564212
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76917220
43VDR_24763502_ChIP-Seq_THP-1_Human1.75915995
44GATA3_27048872_Chip-Seq_THYMUS_Human1.67050688
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65359164
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63094901
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62105054
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59568395
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50852586
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50425360
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46904037
52CIITA_25753668_ChIP-Seq_RAJI_Human1.46507861
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45557334
54* VDR_23849224_ChIP-Seq_CD4+_Human1.45462181
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43689693
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43021076
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37807109
58VDR_24787735_ChIP-Seq_THP-1_Human1.37510561
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36758492
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36306784
61* FOXP3_21729870_ChIP-Seq_TREG_Human1.35633869
62SPI1_23127762_ChIP-Seq_K562_Human1.35222034
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34655102
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.34435889
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32528770
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.31480798
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30614586
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27926016
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.24912864
70KDM2B_26808549_Chip-Seq_DND41_Human1.19357742
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18558425
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18422782
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17872592
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15410156
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15182597
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13325674
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12461928
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11139881
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.10231671
80PU_27001747_Chip-Seq_BMDM_Mouse1.07462330
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07239791
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.07143833
83GATA3_26560356_Chip-Seq_TH2_Human1.07009959
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05683981
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04535501
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01988345
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.01797885
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.00428785
89GATA1_22025678_ChIP-Seq_K562_Human1.00063358
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00008144
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98720196
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97686886
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97402402
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95635256
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94944000
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93744752
97XRN2_22483619_ChIP-Seq_HELA_Human0.91126717
98NCOR1_26117541_ChIP-Seq_K562_Human0.90827965
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90764033
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90502587
101ELK1_19687146_ChIP-ChIP_HELA_Human0.89419526
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88436906
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81753594
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80105517
105RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79951379
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79859279
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79458565
108MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79420685
109BCOR_27268052_Chip-Seq_Bcells_Human0.79212429
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79085570
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78237238
112* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.77827943
113GATA2_19941826_ChIP-Seq_K562_Human0.77259414
114GATA1_19941826_ChIP-Seq_K562_Human0.76915711
115* BCL6_27268052_Chip-Seq_Bcells_Human0.76197651
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75440157
117SMRT_27268052_Chip-Seq_Bcells_Human0.75093112
118ETS1_20019798_ChIP-Seq_JURKAT_Human0.74891094
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.74490101
120RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73441049
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.73021071
122* LXR_22292898_ChIP-Seq_THP-1_Human0.71990554
123GATA3_26560356_Chip-Seq_TH1_Human0.71969597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.18599801
2* MP0005671_abnormal_response_to4.03038237
3MP0000685_abnormal_immune_system3.79372272
4MP0001835_abnormal_antigen_presentation3.73067906
5* MP0001800_abnormal_humoral_immune3.23343650
6MP0009785_altered_susceptibility_to3.01507906
7MP0003724_increased_susceptibility_to3.00372775
8MP0005387_immune_system_phenotype2.91302860
9MP0001790_abnormal_immune_system2.91302860
10MP0002396_abnormal_hematopoietic_system2.90498547
11* MP0002398_abnormal_bone_marrow2.77348342
12* MP0002420_abnormal_adaptive_immunity2.76264511
13* MP0002723_abnormal_immune_serum2.71976662
14* MP0001819_abnormal_immune_cell2.70958439
15MP0005000_abnormal_immune_tolerance2.69589345
16MP0002166_altered_tumor_susceptibility2.66084625
17* MP0002452_abnormal_antigen_presenting2.65748159
18MP0005025_abnormal_response_to2.53016728
19MP0001873_stomach_inflammation2.42478980
20* MP0000716_abnormal_immune_system2.37900056
21MP0003436_decreased_susceptibility_to2.30234671
22* MP0000689_abnormal_spleen_morphology2.23844855
23* MP0002722_abnormal_immune_system2.23556783
24MP0005464_abnormal_platelet_physiology2.19698101
25* MP0004808_abnormal_hematopoietic_stem2.19493893
26MP0002405_respiratory_system_inflammati2.15788798
27MP0009333_abnormal_splenocyte_physiolog2.15068438
28* MP0000703_abnormal_thymus_morphology2.13160688
29* MP0010155_abnormal_intestine_physiology2.10836431
30MP0002006_tumorigenesis2.06264789
31* MP0002429_abnormal_blood_cell2.05437566
32MP0002148_abnormal_hypersensitivity_rea2.00082148
33MP0006082_CNS_inflammation1.97170605
34MP0000465_gastrointestinal_hemorrhage1.92490867
35MP0003300_gastrointestinal_ulcer1.90431944
36MP0001853_heart_inflammation1.86899036
37MP0002419_abnormal_innate_immunity1.86207976
38MP0001545_abnormal_hematopoietic_system1.86052580
39MP0005397_hematopoietic_system_phenotyp1.86052580
40* MP0003866_abnormal_defecation1.78853154
41MP0010368_abnormal_lymphatic_system1.77372661
42MP0005075_abnormal_melanosome_morpholog1.67422614
43MP0004947_skin_inflammation1.66303742
44* MP0001845_abnormal_inflammatory_respons1.60015875
45MP0004510_myositis1.48914037
46MP0002933_joint_inflammation1.42579264
47MP0001879_abnormal_lymphatic_vessel1.42283578
48MP0006054_spinal_hemorrhage1.36243055
49MP0005174_abnormal_tail_pigmentation1.33738890
50MP0009278_abnormal_bone_marrow1.32508286
51MP0008260_abnormal_autophagy1.30227895
52MP0003172_abnormal_lysosome_physiology1.29625247
53MP0003303_peritoneal_inflammation1.20844588
54* MP0008469_abnormal_protein_level1.14536187
55* MP0000490_abnormal_crypts_of1.14231029
56MP0002277_abnormal_respiratory_mucosa1.14033179
57MP0005451_abnormal_body_composition1.11800358
58MP0003828_pulmonary_edema1.07354097
59MP0004147_increased_porphyrin_level1.06765575
60MP0004883_abnormal_blood_vessel1.06149852
61MP0002019_abnormal_tumor_incidence1.06087273
62MP0001533_abnormal_skeleton_physiology1.04958094
63MP0002132_abnormal_respiratory_system1.04330462
64MP0003448_altered_tumor_morphology1.03452792
65MP0001986_abnormal_taste_sensitivity1.02870725
66MP0000858_altered_metastatic_potential1.01374857
67MP0001851_eye_inflammation1.01252997
68MP0002009_preneoplasia0.96989694
69MP0005310_abnormal_salivary_gland0.95129339
70MP0003690_abnormal_glial_cell0.95025778
71MP0000604_amyloidosis0.93528894
72MP0009379_abnormal_foot_pigmentation0.92604538
73MP0004130_abnormal_muscle_cell0.91596254
74MP0002095_abnormal_skin_pigmentation0.91539920
75* MP0003943_abnormal_hepatobiliary_system0.90807394
76MP0008058_abnormal_DNA_repair0.86803352
77MP0003183_abnormal_peptide_metabolism0.85752478
78MP0009763_increased_sensitivity_to0.81943640
79MP0008007_abnormal_cellular_replicative0.79324740
80MP0005164_abnormal_response_to0.78895591
81MP0009764_decreased_sensitivity_to0.77788922
82MP0003075_altered_response_to0.76836312
83MP0009765_abnormal_xenobiotic_induced0.75481609
84MP0003077_abnormal_cell_cycle0.74141040
85MP0000249_abnormal_blood_vessel0.73361365
86MP0005390_skeleton_phenotype0.70781409
87MP0004381_abnormal_hair_follicle0.70203642
88MP0005023_abnormal_wound_healing0.69777688
89MP0001663_abnormal_digestive_system0.68691917
90MP0008057_abnormal_DNA_replication0.67798836
91MP0003279_aneurysm0.67387837
92MP0001348_abnormal_lacrimal_gland0.67192635
93MP0005167_abnormal_blood-brain_barrier0.66841122
94MP0000343_altered_response_to0.66758207
95MP0003191_abnormal_cellular_cholesterol0.66201302
96MP0002998_abnormal_bone_remodeling0.63633679
97MP0003045_fibrosis0.63174144
98MP0002138_abnormal_hepatobiliary_system0.62762780
99MP0005058_abnormal_lysosome_morphology0.62318924
100MP0009840_abnormal_foam_cell0.61774504
101MP0000015_abnormal_ear_pigmentation0.60951480
102MP0002693_abnormal_pancreas_physiology0.59916991
103MP0010094_abnormal_chromosome_stability0.59401693
104MP0008004_abnormal_stomach_pH0.58842675
105MP0000313_abnormal_cell_death0.57932606
106MP0001191_abnormal_skin_condition0.57687648
107MP0008874_decreased_physiological_sensi0.57446323
108* MP0000477_abnormal_intestine_morphology0.56975125
109MP0002136_abnormal_kidney_physiology0.55420873
110MP0005381_digestive/alimentary_phenotyp0.53874229
111MP0003693_abnormal_embryo_hatching0.52944022
112MP0000767_abnormal_smooth_muscle0.51758646
113MP0003091_abnormal_cell_migration0.50101591
114* MP0000598_abnormal_liver_morphology0.49605439
115MP0002163_abnormal_gland_morphology0.49347573
116MP0010352_gastrointestinal_tract_polyps0.48997503
117MP0008961_abnormal_basal_metabolism0.48484703
118MP0002128_abnormal_blood_circulation0.47408643
119MP0009115_abnormal_fat_cell0.46761202
120MP0003795_abnormal_bone_structure0.46580724
121MP0000609_abnormal_liver_physiology0.45832710
122MP0003646_muscle_fatigue0.45092666
123MP0002254_reproductive_system_inflammat0.43471996
124MP0008873_increased_physiological_sensi0.43244371
125MP0004957_abnormal_blastocyst_morpholog0.42880827
126MP0005166_decreased_susceptibility_to0.42842956

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.31692405
2Recurrent bronchitis (HP:0002837)4.92030642
3IgM deficiency (HP:0002850)4.87809681
4T lymphocytopenia (HP:0005403)4.77234909
5Myositis (HP:0100614)4.68112111
6Abnormality of T cell number (HP:0011839)4.58237620
7Abnormality of the nasal mucosa (HP:0000433)4.54987693
8Thrombocytosis (HP:0001894)4.45245092
9Abnormality of macrophages (HP:0004311)4.43865538
10Chronic otitis media (HP:0000389)4.34008388
11Abnormality of T cells (HP:0002843)4.16846368
12Agammaglobulinemia (HP:0004432)4.10922896
13Panhypogammaglobulinemia (HP:0003139)4.04477826
14Spontaneous hematomas (HP:0007420)4.00553998
15Nasal polyposis (HP:0100582)3.94770765
16Recurrent gram-negative bacterial infections (HP:0005420)3.83569763
17IgG deficiency (HP:0004315)3.83055730
18Recurrent viral infections (HP:0004429)3.70766281
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.67258230
20Lymphopenia (HP:0001888)3.65117524
21Inflammation of the large intestine (HP:0002037)3.60810767
22Recurrent fungal infections (HP:0002841)3.56638385
23Gastrointestinal inflammation (HP:0004386)3.56430464
24Severe combined immunodeficiency (HP:0004430)3.53575785
25Abnormality of cells of the lymphoid lineage (HP:0012140)3.48811927
26Obstructive lung disease (HP:0006536)3.45314143
27Chronic obstructive pulmonary disease (HP:0006510)3.45314143
28B lymphocytopenia (HP:0010976)3.39602059
29Abnormality of B cell number (HP:0010975)3.39602059
30Abnormality of T cell physiology (HP:0011840)3.37879686
31Prolonged bleeding time (HP:0003010)3.37307496
32Abnormality of the fingertips (HP:0001211)3.31895755
33Gastrointestinal stroma tumor (HP:0100723)3.30354612
34Meningitis (HP:0001287)3.30325659
35Petechiae (HP:0000967)3.26039036
36Recurrent cutaneous fungal infections (HP:0011370)3.24057740
37Chronic mucocutaneous candidiasis (HP:0002728)3.24057740
38Combined immunodeficiency (HP:0005387)3.22863832
39Colitis (HP:0002583)3.22400925
40Epistaxis (HP:0000421)3.19559745
41Retrobulbar optic neuritis (HP:0100654)3.12397105
42Optic neuritis (HP:0100653)3.12397105
43Vasculitis (HP:0002633)3.12042563
44Pustule (HP:0200039)3.10956377
45Orchitis (HP:0100796)3.10067605
46Stomatitis (HP:0010280)3.04005933
47Gingivitis (HP:0000230)2.99586882
48Encephalitis (HP:0002383)2.95257154
49IgA deficiency (HP:0002720)2.92335844
50Autoimmune hemolytic anemia (HP:0001890)2.91950514
51Chronic diarrhea (HP:0002028)2.89846890
52Hemoptysis (HP:0002105)2.85324959
53Thyroiditis (HP:0100646)2.84737526
54Lymphoma (HP:0002665)2.84165599
55Aplastic anemia (HP:0001915)2.83240157
56Bronchitis (HP:0012387)2.81351175
57Recurrent abscess formation (HP:0002722)2.78873587
58Amaurosis fugax (HP:0100576)2.77196210
59Eczematoid dermatitis (HP:0000976)2.76793362
60Cellulitis (HP:0100658)2.74865175
61Abnormality of eosinophils (HP:0001879)2.72175652
62Microcytic anemia (HP:0001935)2.68236925
63Recurrent sinusitis (HP:0011108)2.68196429
64Arterial thrombosis (HP:0004420)2.59350175
65Urticaria (HP:0001025)2.58472401
66Autoimmune thrombocytopenia (HP:0001973)2.56508734
67Leukocytosis (HP:0001974)2.56171965
68Hematochezia (HP:0002573)2.54135210
69Hypochromic anemia (HP:0001931)2.52119106
70Abnormality of cells of the erythroid lineage (HP:0012130)2.51475544
71Anorexia (HP:0002039)2.50487989
72Chronic sinusitis (HP:0011109)2.50458128
73Mediastinal lymphadenopathy (HP:0100721)2.48685829
74Abnormal platelet function (HP:0011869)2.45389602
75Impaired platelet aggregation (HP:0003540)2.45389602
76Basal cell carcinoma (HP:0002671)2.45235118
77Pulmonary infiltrates (HP:0002113)2.44965464
78Joint swelling (HP:0001386)2.44787749
79Recurrent skin infections (HP:0001581)2.44364358
80Chest pain (HP:0100749)2.42369813
81Abnormal number of erythroid precursors (HP:0012131)2.41764120
82Papilledema (HP:0001085)2.40194132
83Pulmonary embolism (HP:0002204)2.39140062
84Muscle fiber atrophy (HP:0100295)2.36465657
85Gangrene (HP:0100758)2.35900061
86Type 2 muscle fiber atrophy (HP:0003554)2.33693011
87Granulocytopenia (HP:0001913)2.32781789
88Increased IgE level (HP:0003212)2.29873767
89Keratoconjunctivitis sicca (HP:0001097)2.26570718
90Papilloma (HP:0012740)2.25886706
91Verrucae (HP:0200043)2.25886706
92Purpura (HP:0000979)2.25075265
93Reticulocytopenia (HP:0001896)2.24846393
94Emphysema (HP:0002097)2.23010890
95Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22665029
96Gingival bleeding (HP:0000225)2.22323216
97Hypochromic microcytic anemia (HP:0004840)2.21915747
98Abnormality of the pleura (HP:0002103)2.21675436
99Eosinophilia (HP:0001880)2.20712206
100Increased IgM level (HP:0003496)2.18667178
101Hypoproteinemia (HP:0003075)2.15598593
102Abnormality of the prostate (HP:0008775)2.15369010
103Fatigue (HP:0012378)2.12340253
104Slow saccadic eye movements (HP:0000514)2.11442794
105Recurrent bacterial skin infections (HP:0005406)2.09457309
106Interstitial pulmonary disease (HP:0006530)2.07905724
107Hypergammaglobulinemia (HP:0010702)2.06569149
108Episodic fever (HP:0001954)2.05859065
109Acute hepatic failure (HP:0006554)2.05359409
110Acute myeloid leukemia (HP:0004808)2.03840570
111Hypoplasia of the thymus (HP:0000778)2.03217101
112Keratoconjunctivitis (HP:0001096)2.02949086
113Sepsis (HP:0100806)2.02201025
114Glomerulopathy (HP:0100820)2.00560586
115Gastrointestinal infarctions (HP:0005244)1.96695449
116Pallor (HP:0000980)1.92422204
117Acne (HP:0001061)1.92356263
118Skin rash (HP:0000988)1.91711695
119Stomach cancer (HP:0012126)1.91701817
120Polycythemia (HP:0001901)1.90783218
121Abnormality of the endocardium (HP:0004306)1.89732520
122Polyneuropathy (HP:0001271)1.89233240
123Arthralgia (HP:0002829)1.87226709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.46344610
2TXK4.82934034
3TIE13.40005309
4RIPK43.30629205
5TGFBR12.82882722
6ZAP702.81080246
7TGFBR22.77065635
8KDR2.72536532
9JAK32.71703525
10FGFR42.45724694
11IKBKE2.43997894
12ITK2.24567110
13KIT2.23435269
14TEC2.16367858
15STK102.12785510
16NME22.10679099
17TBK12.00838072
18PRPF4B1.97949965
19MAP3K141.96009709
20NLK1.95347872
21BTK1.90394204
22TYK21.86425071
23EEF2K1.73870296
24SYK1.62597903
25LCK1.59094143
26FGFR31.58180283
27MAP2K31.56481902
28CAMKK21.46504610
29JAK11.45508216
30IKBKB1.43654262
31LRRK21.41631860
32MAP3K131.31601444
33GRK61.29712796
34FGR1.26339429
35CAMKK11.22853756
36IRAK41.19234204
37HCK1.11875409
38CSK1.08850988
39FLT31.08624944
40BLK1.03323023
41CSF1R1.02718886
42MAP2K61.01914946
43MAP3K31.01590697
44PIM10.99530876
45LYN0.98492164
46MAP3K100.98446870
47ERN10.94702959
48RPS6KA40.92888252
49CLK10.91717516
50CHUK0.89048648
51FES0.88741672
52MUSK0.87732533
53PRKD20.85662965
54MAP3K10.81683934
55GRK70.81390083
56MAP3K120.80395793
57TYRO30.78217515
58MAP3K70.77617155
59PRKCH0.75623765
60PRKCQ0.71420655
61PKN20.68729323
62FYN0.68574522
63MST40.65103569
64IRAK30.63794111
65PASK0.63442868
66TAOK20.63224828
67RPS6KB20.63151575
68PRKG20.62021140
69BMPR20.60916014
70MARK30.60264158
71MATK0.57090188
72EPHA30.56762834
73CDC42BPA0.56381074
74SIK30.56170675
75TNK20.53478297
76JAK20.53372569
77PIM20.53146447
78HIPK20.52536532
79YES10.52133544
80SIK20.51913231
81TNIK0.51139412
82ACVR1B0.50167992
83TSSK60.48300129
84RIPK10.46291511
85PTK60.45306624
86PTK2B0.44331134
87EPHB10.44151559
88KSR20.42871990
89PDGFRB0.42780477
90CDK80.41622710
91CDK90.41418069
92MAPK120.40881440
93TAOK30.40596904
94MAPK110.40416058
95MARK20.40234657
96PDPK10.38248813
97STK380.37320403
98MAPK70.35772666
99TLK10.35319964
100PLK40.35122738
101SRPK10.34916073
102MAP3K110.34805931
103MYLK0.33369702
104MAP2K20.32899416
105RPS6KA50.32731649
106CDK40.32186316
107STK110.31465604
108MAPK40.31371174
109EGFR0.30254812
110MAP3K50.30042038
111PDK10.29788376
112MAPKAPK20.29468117
113RET0.29227546
114MAP3K60.28530958
115IGF1R0.28086091
116DYRK1B0.26122527
117PIK3CG0.24826332
118IRAK10.24386121
119CAMK10.24130149
120SIK10.23962124
121MAPK30.23866092
122GRK10.23409771
123CDK60.23222836
124ADRBK20.23180906
125ABL10.21420396
126ATR0.20770753
127RAF10.20057968
128TRIB30.20032945
129TAOK10.19192699
130INSR0.18707316
131TESK20.18485276

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.97797041
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.94356653
3Ribosome_Homo sapiens_hsa030102.82228897
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.80940240
5T cell receptor signaling pathway_Homo sapiens_hsa046602.78996591
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.66454069
7Measles_Homo sapiens_hsa051622.59204151
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.54009007
9Graft-versus-host disease_Homo sapiens_hsa053322.42123990
10Allograft rejection_Homo sapiens_hsa053302.42094859
11B cell receptor signaling pathway_Homo sapiens_hsa046622.41253939
12Antigen processing and presentation_Homo sapiens_hsa046122.37823124
13Hematopoietic cell lineage_Homo sapiens_hsa046402.30563357
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16373882
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02515254
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.99749893
17Leishmaniasis_Homo sapiens_hsa051401.96665339
18Autoimmune thyroid disease_Homo sapiens_hsa053201.71528783
19Herpes simplex infection_Homo sapiens_hsa051681.70374756
20Osteoclast differentiation_Homo sapiens_hsa043801.68104501
21Shigellosis_Homo sapiens_hsa051311.45642200
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43872712
23Viral myocarditis_Homo sapiens_hsa054161.41321203
24Acute myeloid leukemia_Homo sapiens_hsa052211.38953230
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36933804
26Platelet activation_Homo sapiens_hsa046111.36754635
27Toxoplasmosis_Homo sapiens_hsa051451.34419626
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.32991553
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30607107
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23637684
31Malaria_Homo sapiens_hsa051441.23258537
32Base excision repair_Homo sapiens_hsa034101.23016379
33DNA replication_Homo sapiens_hsa030301.20474723
34Influenza A_Homo sapiens_hsa051641.19691027
35Hepatitis B_Homo sapiens_hsa051611.19000018
36TNF signaling pathway_Homo sapiens_hsa046681.15297205
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13697409
38Mismatch repair_Homo sapiens_hsa034301.08116560
39Spliceosome_Homo sapiens_hsa030401.07855722
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05988208
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05570805
42Apoptosis_Homo sapiens_hsa042101.04361642
43Chemokine signaling pathway_Homo sapiens_hsa040621.02797767
44Epstein-Barr virus infection_Homo sapiens_hsa051690.99642938
45Caffeine metabolism_Homo sapiens_hsa002320.98387358
46HTLV-I infection_Homo sapiens_hsa051660.98041139
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96000962
48Asthma_Homo sapiens_hsa053100.95667861
49Prolactin signaling pathway_Homo sapiens_hsa049170.89751868
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87980779
51Type I diabetes mellitus_Homo sapiens_hsa049400.87400856
52Hepatitis C_Homo sapiens_hsa051600.86582300
53Pertussis_Homo sapiens_hsa051330.85180989
54Chronic myeloid leukemia_Homo sapiens_hsa052200.85131602
55Non-homologous end-joining_Homo sapiens_hsa034500.83054052
56RNA degradation_Homo sapiens_hsa030180.82984748
57Legionellosis_Homo sapiens_hsa051340.82866842
58Phagosome_Homo sapiens_hsa041450.81784680
59Pancreatic cancer_Homo sapiens_hsa052120.77187136
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70727138
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69695378
62Viral carcinogenesis_Homo sapiens_hsa052030.69234131
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69055574
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66160520
65Salmonella infection_Homo sapiens_hsa051320.65997175
66Colorectal cancer_Homo sapiens_hsa052100.65618261
67African trypanosomiasis_Homo sapiens_hsa051430.64658149
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.64469816
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.64114680
70VEGF signaling pathway_Homo sapiens_hsa043700.64028777
71Notch signaling pathway_Homo sapiens_hsa043300.61187927
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59448729
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59383758
74Endocytosis_Homo sapiens_hsa041440.59374856
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57750649
76RNA polymerase_Homo sapiens_hsa030200.57714181
77Thyroid cancer_Homo sapiens_hsa052160.57162378
78Regulation of autophagy_Homo sapiens_hsa041400.55443248
79p53 signaling pathway_Homo sapiens_hsa041150.55303288
80Small cell lung cancer_Homo sapiens_hsa052220.54237175
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54188805
82Pyrimidine metabolism_Homo sapiens_hsa002400.54081430
83Tuberculosis_Homo sapiens_hsa051520.53450032
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53269364
85Nucleotide excision repair_Homo sapiens_hsa034200.53085536
86Non-small cell lung cancer_Homo sapiens_hsa052230.47678920
87Homologous recombination_Homo sapiens_hsa034400.47284203
88Renal cell carcinoma_Homo sapiens_hsa052110.45401057
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.45275212
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45139636
91Lysosome_Homo sapiens_hsa041420.44636119
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42300937
93Choline metabolism in cancer_Homo sapiens_hsa052310.41814525
94Staphylococcus aureus infection_Homo sapiens_hsa051500.41379223
95Proteasome_Homo sapiens_hsa030500.40410479
96Sulfur relay system_Homo sapiens_hsa041220.39899660
97MAPK signaling pathway_Homo sapiens_hsa040100.38148797
98Inositol phosphate metabolism_Homo sapiens_hsa005620.38135331
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37394778
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36755689
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.36503475
102Endometrial cancer_Homo sapiens_hsa052130.35779412
103Insulin resistance_Homo sapiens_hsa049310.34896014
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33310117
105Ras signaling pathway_Homo sapiens_hsa040140.32642429
106Fanconi anemia pathway_Homo sapiens_hsa034600.32055117
107Other glycan degradation_Homo sapiens_hsa005110.31967205
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31774496
109Dorso-ventral axis formation_Homo sapiens_hsa043200.31541295
110Basal transcription factors_Homo sapiens_hsa030220.31303418
111Rap1 signaling pathway_Homo sapiens_hsa040150.31206218
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30534355
113HIF-1 signaling pathway_Homo sapiens_hsa040660.29361229
114FoxO signaling pathway_Homo sapiens_hsa040680.28659741
115mTOR signaling pathway_Homo sapiens_hsa041500.28463962
116RNA transport_Homo sapiens_hsa030130.27077254
117Pathways in cancer_Homo sapiens_hsa052000.26751761
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25901907
119Amoebiasis_Homo sapiens_hsa051460.24662064
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.24064533
121GnRH signaling pathway_Homo sapiens_hsa049120.22473630
122Rheumatoid arthritis_Homo sapiens_hsa053230.21873146
123Cell cycle_Homo sapiens_hsa041100.21519699
124N-Glycan biosynthesis_Homo sapiens_hsa005100.20818902
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20769032
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.19953672
127Protein export_Homo sapiens_hsa030600.18716909
128Linoleic acid metabolism_Homo sapiens_hsa005910.18702300

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