GIMAP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.63647298
2regulation of gamma-delta T cell differentiation (GO:0045586)6.67001450
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.30367071
4regulation of gamma-delta T cell activation (GO:0046643)6.05977359
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.01634357
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.01634357
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.62128612
8positive thymic T cell selection (GO:0045059)5.51930187
9negative T cell selection (GO:0043383)5.49084670
10antigen processing and presentation of endogenous antigen (GO:0019883)5.44256827
11negative thymic T cell selection (GO:0045060)5.37649479
12response to interleukin-15 (GO:0070672)5.03873921
13regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.91693673
14cellular response to interleukin-15 (GO:0071350)4.82639474
15thymic T cell selection (GO:0045061)4.79419726
16positive T cell selection (GO:0043368)4.77434557
17regulation of regulatory T cell differentiation (GO:0045589)4.76123643
18antigen processing and presentation via MHC class Ib (GO:0002475)4.73352527
19negative regulation of cell killing (GO:0031342)4.69633649
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.69633649
21regulation of B cell receptor signaling pathway (GO:0050855)4.66354607
22regulation of isotype switching to IgG isotypes (GO:0048302)4.57879885
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.54026136
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.47404939
25interferon-gamma production (GO:0032609)4.47064845
26T cell selection (GO:0045058)4.44084207
27negative regulation of T cell mediated immunity (GO:0002710)4.32505769
28T cell migration (GO:0072678)4.21261615
29regulation of interleukin-12 biosynthetic process (GO:0045075)4.14642190
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.13380866
31ribosomal small subunit assembly (GO:0000028)4.10058627
32positive regulation by symbiont of host defense response (GO:0052509)4.08629565
33modulation by symbiont of host defense response (GO:0052031)4.08629565
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.08629565
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.08629565
36positive regulation by organism of defense response of other organism involved in symbiotic interact4.08629565
37modulation by symbiont of host immune response (GO:0052553)4.08629565
38detection of other organism (GO:0098543)4.03555143
39regulation of B cell differentiation (GO:0045577)4.00155718
40negative regulation of leukocyte mediated immunity (GO:0002704)3.97707841
41detection of bacterium (GO:0016045)3.94778045
42tolerance induction (GO:0002507)3.93052286
43B cell receptor signaling pathway (GO:0050853)3.89128246
44mature B cell differentiation involved in immune response (GO:0002313)3.88346447
45T cell receptor signaling pathway (GO:0050852)3.87683043
46response to type I interferon (GO:0034340)3.87551973
47antigen receptor-mediated signaling pathway (GO:0050851)3.84483223
48positive regulation of B cell differentiation (GO:0045579)3.81781345
49regulation of T cell tolerance induction (GO:0002664)3.81206425
50cellular response to type I interferon (GO:0071357)3.81086397
51type I interferon signaling pathway (GO:0060337)3.81086397
52regulation of alpha-beta T cell proliferation (GO:0046640)3.79223059
53positive regulation of natural killer cell mediated immunity (GO:0002717)3.76888941
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.76888941
55neutrophil activation involved in immune response (GO:0002283)3.72739912
56mature B cell differentiation (GO:0002335)3.72449863
57mast cell activation (GO:0045576)3.69912472
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69729732
59T cell homeostasis (GO:0043029)3.64881245
60lymph node development (GO:0048535)3.63706817
61leukocyte aggregation (GO:0070486)3.61345105
62negative regulation of interleukin-12 production (GO:0032695)3.60407132
63regulation of natural killer cell mediated immunity (GO:0002715)3.59809225
64regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.59809225
65negative regulation of erythrocyte differentiation (GO:0045647)3.57543872
66definitive hemopoiesis (GO:0060216)3.56928334
67regulation of T cell receptor signaling pathway (GO:0050856)3.56561065
68viral transcription (GO:0019083)3.56419958
69activated T cell proliferation (GO:0050798)3.55759855
70positive regulation of humoral immune response (GO:0002922)3.51541767
71response to interferon-beta (GO:0035456)3.51525610
72lymphocyte costimulation (GO:0031294)3.50030794
73T cell costimulation (GO:0031295)3.49796342
74positive regulation of tolerance induction (GO:0002645)3.48506273
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.47842452
76regulation of T cell mediated cytotoxicity (GO:0001914)3.45397104
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.44167586
78regulation of leukocyte mediated cytotoxicity (GO:0001910)3.43972051
79positive regulation of interleukin-2 production (GO:0032743)3.40990117
80macrophage activation involved in immune response (GO:0002281)3.40856387
81cellular extravasation (GO:0045123)3.39458117
82negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.39413408
83positive regulation of T cell mediated cytotoxicity (GO:0001916)3.38967643
84translational termination (GO:0006415)3.37316066
85positive regulation of isotype switching (GO:0045830)3.36717946
86immunoglobulin mediated immune response (GO:0016064)3.35435508
87T cell differentiation (GO:0030217)3.35230900
88myeloid dendritic cell activation (GO:0001773)3.34142216
89megakaryocyte development (GO:0035855)3.33858332
90interferon-gamma-mediated signaling pathway (GO:0060333)3.33412492
91regulation of response to interferon-gamma (GO:0060330)3.32348429
92regulation of type I interferon-mediated signaling pathway (GO:0060338)3.31868048
93detection of external biotic stimulus (GO:0098581)3.27225298
94regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.25023967
95NIK/NF-kappaB signaling (GO:0038061)3.24731170
96response to muramyl dipeptide (GO:0032495)3.23011033
97negative regulation of innate immune response (GO:0045824)3.22978276
98positive regulation of B cell mediated immunity (GO:0002714)3.22606927
99positive regulation of immunoglobulin mediated immune response (GO:0002891)3.22606927
100negative regulation of nitric oxide biosynthetic process (GO:0045019)3.21850039
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19394734
102regulation of interferon-beta biosynthetic process (GO:0045357)3.17358813
103neutrophil activation (GO:0042119)3.16155359
104regulation of B cell mediated immunity (GO:0002712)3.16009143
105lymphocyte homeostasis (GO:0002260)3.15548807
106regulation of tolerance induction (GO:0002643)3.15330229
107response to protozoan (GO:0001562)3.13458586
108regulation of immunoglobulin mediated immune response (GO:0002889)3.12602755
109cellular response to interferon-beta (GO:0035458)3.11942695
110positive regulation of DNA recombination (GO:0045911)3.11673519
111regulation of cell killing (GO:0031341)3.10637056
112positive regulation of cell killing (GO:0031343)3.09982740
113defense response to protozoan (GO:0042832)3.09960421
114platelet dense granule organization (GO:0060155)3.09814935
115regulation of isotype switching (GO:0045191)3.08253117
116response to peptidoglycan (GO:0032494)3.06421322
117Peyers patch development (GO:0048541)3.05684506
118mucosal-associated lymphoid tissue development (GO:0048537)3.05684506
119leukocyte homeostasis (GO:0001776)3.05465925
120positive regulation of granulocyte differentiation (GO:0030854)3.04390095
121negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04277549
122mast cell activation involved in immune response (GO:0002279)3.03843888
123mast cell degranulation (GO:0043303)3.03843888
124CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.03283954
125myeloid cell activation involved in immune response (GO:0002275)3.03123795
126ribosomal small subunit biogenesis (GO:0042274)3.02414971
127myeloid dendritic cell differentiation (GO:0043011)3.01164269
128respiratory burst (GO:0045730)2.95899847
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93216219
130dendritic cell chemotaxis (GO:0002407)2.93211654
131leukocyte degranulation (GO:0043299)2.92843385
132regulation of T cell mediated immunity (GO:0002709)2.90806501
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86882165
134dendritic cell migration (GO:0036336)2.86216328
135response to host immune response (GO:0052572)2.85224212
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85224212
137germinal center formation (GO:0002467)2.84421256
138regulation of interleukin-2 biosynthetic process (GO:0045076)2.83707142
139detection of biotic stimulus (GO:0009595)2.83434908
140detection of molecule of bacterial origin (GO:0032490)2.82322852
141granulocyte activation (GO:0036230)2.82175671
142negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80910214
143negative regulation of T-helper cell differentiation (GO:0045623)2.80910214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.60328046
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.53469207
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.23606984
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.64748535
5SCL_19346495_ChIP-Seq_HPC-7_Human3.71014953
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64204624
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60324891
8RUNX_20019798_ChIP-Seq_JUKART_Human3.49212954
9STAT4_19710469_ChIP-ChIP_TH1__Mouse3.29893412
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.29118655
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.24586199
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23892120
13MYC_22102868_ChIP-Seq_BL_Human3.07428374
14* NOTCH1_21737748_ChIP-Seq_TLL_Human3.03697041
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02930260
16MYB_26560356_Chip-Seq_TH2_Human2.98945343
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74907826
18* MAF_26560356_Chip-Seq_TH1_Human2.72093851
19MYB_26560356_Chip-Seq_TH1_Human2.62442242
20* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.44524081
21UTX_26944678_Chip-Seq_JUKART_Human2.39653437
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37141671
23* IRF8_21731497_ChIP-ChIP_J774_Mouse2.36596022
24* SPI1_23547873_ChIP-Seq_NB4_Human2.24336420
25* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18476779
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.17412461
27VDR_21846776_ChIP-Seq_THP-1_Human2.14927719
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11152955
29* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.07969425
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.04624597
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02808082
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.99831266
33* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97612111
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95979416
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89194292
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.85914279
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83611523
38TCF7_22412390_ChIP-Seq_EML_Mouse1.82741443
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76316161
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75671046
41MAF_26560356_Chip-Seq_TH2_Human1.74864359
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.74580635
43VDR_24763502_ChIP-Seq_THP-1_Human1.73021032
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70919362
45E2F7_22180533_ChIP-Seq_HELA_Human1.68293392
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67472247
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.55386116
48VDR_24787735_ChIP-Seq_THP-1_Human1.51228984
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50182501
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48887591
51* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48670430
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47654245
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46460482
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45029783
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39961264
56SPI1_23127762_ChIP-Seq_K562_Human1.39372889
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38153785
58* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37752699
59CIITA_25753668_ChIP-Seq_RAJI_Human1.36622040
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.33352288
61VDR_23849224_ChIP-Seq_CD4+_Human1.32087375
62FOXP3_21729870_ChIP-Seq_TREG_Human1.28933114
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28099356
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26866628
65GATA3_26560356_Chip-Seq_TH2_Human1.23418594
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23204278
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.20996615
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20958401
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.20813463
70GATA1_22025678_ChIP-Seq_K562_Human1.18692046
71PU_27001747_Chip-Seq_BMDM_Mouse1.17491187
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16825969
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15704401
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13786624
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13624615
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11757051
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09748919
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07116432
79KDM2B_26808549_Chip-Seq_DND41_Human1.06310217
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05917902
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05716084
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05678089
83ELK1_19687146_ChIP-ChIP_HELA_Human1.03514569
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.99272076
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99188497
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99133500
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98572036
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97930679
89LXR_22292898_ChIP-Seq_THP-1_Human0.92457217
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92128731
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.91387381
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91175534
93BCOR_27268052_Chip-Seq_Bcells_Human0.87403406
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87334300
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83129740
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82841253
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82304684
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81430959
99NCOR1_26117541_ChIP-Seq_K562_Human0.80318893
100GATA1_19941826_ChIP-Seq_K562_Human0.80076816
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79668205
102ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79647035
103EST1_17652178_ChIP-ChIP_JURKAT_Human0.79509198
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78977453
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78847869
106PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77968808
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77914775
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77546038
109* SPI1_20517297_ChIP-Seq_HL60_Human0.77448299
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77283246
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76329950
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.76110841
113MYC_18555785_ChIP-Seq_MESCs_Mouse0.73984666
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72159247
115GATA2_19941826_ChIP-Seq_K562_Human0.71138812
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70535614
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.68791076
118BCL6_27268052_Chip-Seq_Bcells_Human0.67095414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.44440488
2MP0005671_abnormal_response_to4.35891770
3MP0000685_abnormal_immune_system3.86341489
4MP0001835_abnormal_antigen_presentation3.77064438
5MP0009785_altered_susceptibility_to3.31554196
6MP0001800_abnormal_humoral_immune3.25351158
7MP0003724_increased_susceptibility_to2.99666108
8MP0005387_immune_system_phenotype2.93369603
9MP0001790_abnormal_immune_system2.93369603
10MP0002166_altered_tumor_susceptibility2.84224590
11MP0002420_abnormal_adaptive_immunity2.77569843
12MP0002723_abnormal_immune_serum2.76571709
13MP0002398_abnormal_bone_marrow2.73757431
14MP0001819_abnormal_immune_cell2.73125506
15MP0002396_abnormal_hematopoietic_system2.72053106
16MP0005000_abnormal_immune_tolerance2.71586513
17MP0002452_abnormal_antigen_presenting2.70621089
18MP0005025_abnormal_response_to2.53998500
19MP0004808_abnormal_hematopoietic_stem2.40680967
20MP0000716_abnormal_immune_system2.38660677
21MP0001873_stomach_inflammation2.37883265
22MP0000689_abnormal_spleen_morphology2.28076544
23MP0009333_abnormal_splenocyte_physiolog2.25448872
24MP0002722_abnormal_immune_system2.21843151
25MP0010155_abnormal_intestine_physiology2.18348790
26MP0002405_respiratory_system_inflammati2.15549190
27MP0002006_tumorigenesis2.13749585
28MP0000703_abnormal_thymus_morphology2.13555648
29MP0003866_abnormal_defecation2.12465525
30MP0002148_abnormal_hypersensitivity_rea2.10227124
31MP0005464_abnormal_platelet_physiology2.05865878
32MP0003436_decreased_susceptibility_to2.04859686
33MP0002429_abnormal_blood_cell2.02660312
34MP0006082_CNS_inflammation1.98683376
35MP0002419_abnormal_innate_immunity1.89785168
36MP0004947_skin_inflammation1.82471794
37MP0001879_abnormal_lymphatic_vessel1.78450832
38MP0001853_heart_inflammation1.75455461
39MP0005075_abnormal_melanosome_morpholog1.75305027
40MP0010368_abnormal_lymphatic_system1.66815675
41MP0003300_gastrointestinal_ulcer1.64983458
42MP0001545_abnormal_hematopoietic_system1.61423444
43MP0005397_hematopoietic_system_phenotyp1.61423444
44MP0001845_abnormal_inflammatory_respons1.60499469
45MP0004510_myositis1.57942740
46MP0000465_gastrointestinal_hemorrhage1.57458518
47MP0004147_increased_porphyrin_level1.50919764
48MP0002933_joint_inflammation1.49902319
49MP0005174_abnormal_tail_pigmentation1.40455135
50MP0000490_abnormal_crypts_of1.30691215
51MP0009278_abnormal_bone_marrow1.27141281
52MP0008260_abnormal_autophagy1.24378659
53MP0008469_abnormal_protein_level1.21211941
54MP0006054_spinal_hemorrhage1.18672220
55MP0004130_abnormal_muscle_cell1.17796232
56MP0009379_abnormal_foot_pigmentation1.15494972
57MP0003828_pulmonary_edema1.13260939
58MP0003943_abnormal_hepatobiliary_system1.12897447
59MP0002009_preneoplasia1.10158825
60MP0004883_abnormal_blood_vessel1.09971611
61MP0001851_eye_inflammation1.07191747
62MP0002095_abnormal_skin_pigmentation1.07040426
63MP0003690_abnormal_glial_cell1.00007585
64MP0001533_abnormal_skeleton_physiology0.99271862
65MP0002019_abnormal_tumor_incidence0.97426997
66MP0005310_abnormal_salivary_gland0.95147195
67MP0000858_altered_metastatic_potential0.92362259
68MP0003183_abnormal_peptide_metabolism0.92231203
69MP0002277_abnormal_respiratory_mucosa0.91367425
70MP0003303_peritoneal_inflammation0.90573549
71MP0008995_early_reproductive_senescence0.90486958
72MP0000015_abnormal_ear_pigmentation0.88868959
73MP0003172_abnormal_lysosome_physiology0.88532283
74MP0005166_decreased_susceptibility_to0.88406150
75MP0004381_abnormal_hair_follicle0.87642391
76MP0003448_altered_tumor_morphology0.87451313
77MP0002132_abnormal_respiratory_system0.87041108
78MP0003075_altered_response_to0.84954103
79MP0008058_abnormal_DNA_repair0.81285587
80MP0005164_abnormal_response_to0.78678294
81MP0005390_skeleton_phenotype0.77773812
82MP0005451_abnormal_body_composition0.76546091
83MP0000249_abnormal_blood_vessel0.74943736
84MP0002138_abnormal_hepatobiliary_system0.71490052
85MP0005409_darkened_coat_color0.71206370
86MP0002998_abnormal_bone_remodeling0.70601318
87MP0009763_increased_sensitivity_to0.70479324
88MP0004484_altered_response_of0.68486293
89MP0005058_abnormal_lysosome_morphology0.66824675
90MP0003045_fibrosis0.66388393
91MP0008007_abnormal_cellular_replicative0.66036501
92MP0009764_decreased_sensitivity_to0.65733904
93MP0000604_amyloidosis0.64171060
94MP0001191_abnormal_skin_condition0.62522156
95MP0005167_abnormal_blood-brain_barrier0.62231996
96MP0009765_abnormal_xenobiotic_induced0.61440025
97MP0008057_abnormal_DNA_replication0.60880203
98MP0000343_altered_response_to0.60436261
99MP0008874_decreased_physiological_sensi0.60184488
100MP0003191_abnormal_cellular_cholesterol0.59464066
101MP0002136_abnormal_kidney_physiology0.58698683
102MP0000477_abnormal_intestine_morphology0.57766374
103MP0005023_abnormal_wound_healing0.57745717
104MP0001986_abnormal_taste_sensitivity0.57277309
105MP0003786_premature_aging0.53697705
106MP0009115_abnormal_fat_cell0.53579843
107MP0003077_abnormal_cell_cycle0.52852350
108MP0003279_aneurysm0.52518134
109MP0000767_abnormal_smooth_muscle0.52202906
110MP0003091_abnormal_cell_migration0.49893302
111MP0001663_abnormal_digestive_system0.49307981
112MP0005388_respiratory_system_phenotype0.49199855
113MP0002133_abnormal_respiratory_system0.49199855
114MP0000313_abnormal_cell_death0.48704886
115MP0000372_irregular_coat_pigmentation0.48412362
116MP0003656_abnormal_erythrocyte_physiolo0.47799537
117MP0000609_abnormal_liver_physiology0.46756579
118MP0009697_abnormal_copulation0.46007634
119MP0008004_abnormal_stomach_pH0.45760902
120MP0000598_abnormal_liver_morphology0.44442025
121MP0003795_abnormal_bone_structure0.43297371
122MP0005084_abnormal_gallbladder_morpholo0.43125312
123MP0005334_abnormal_fat_pad0.42988137
124MP0003638_abnormal_response/metabolism_0.42180187
125MP0002928_abnormal_bile_duct0.41979894

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.28961018
2IgM deficiency (HP:0002850)5.21787982
3T lymphocytopenia (HP:0005403)5.12046606
4Abnormality of T cell number (HP:0011839)5.02588430
5Recurrent bronchitis (HP:0002837)4.98574161
6Myositis (HP:0100614)4.70125134
7Chronic otitis media (HP:0000389)4.52544034
8Abnormality of T cells (HP:0002843)4.45416212
9Panhypogammaglobulinemia (HP:0003139)4.42634054
10IgG deficiency (HP:0004315)4.23254319
11Abnormality of macrophages (HP:0004311)4.17834993
12Agammaglobulinemia (HP:0004432)4.10170371
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.08935607
14Gastrointestinal infarctions (HP:0005244)4.03522174
15Abnormality of the nasal mucosa (HP:0000433)3.98249116
16Thrombocytosis (HP:0001894)3.92435418
17Recurrent viral infections (HP:0004429)3.90734615
18Severe combined immunodeficiency (HP:0004430)3.89737067
19Lymphopenia (HP:0001888)3.86698643
20Spontaneous hematomas (HP:0007420)3.84277029
21Abnormality of B cell number (HP:0010975)3.83594665
22B lymphocytopenia (HP:0010976)3.83594665
23Recurrent gram-negative bacterial infections (HP:0005420)3.76380946
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.68695407
25Abnormality of T cell physiology (HP:0011840)3.67879032
26Thyroiditis (HP:0100646)3.60848158
27Nasal polyposis (HP:0100582)3.59528847
28Recurrent fungal infections (HP:0002841)3.52306426
29Combined immunodeficiency (HP:0005387)3.47635091
30Prolonged bleeding time (HP:0003010)3.47333228
31Stomatitis (HP:0010280)3.42690169
32Inflammation of the large intestine (HP:0002037)3.39023288
33Obstructive lung disease (HP:0006536)3.37434135
34Chronic obstructive pulmonary disease (HP:0006510)3.37434135
35Gastrointestinal inflammation (HP:0004386)3.32750656
36Meningitis (HP:0001287)3.29322343
37Colitis (HP:0002583)3.24603445
38Retrobulbar optic neuritis (HP:0100654)3.22738757
39Optic neuritis (HP:0100653)3.22738757
40Recurrent cutaneous fungal infections (HP:0011370)3.21762577
41Chronic mucocutaneous candidiasis (HP:0002728)3.21762577
42Autoimmune hemolytic anemia (HP:0001890)3.16146813
43Recurrent sinusitis (HP:0011108)3.13598246
44Orchitis (HP:0100796)3.11546910
45Recurrent abscess formation (HP:0002722)3.11292148
46Vasculitis (HP:0002633)3.10697963
47Abnormality of eosinophils (HP:0001879)3.06139258
48Gastrointestinal stroma tumor (HP:0100723)3.02976627
49Epistaxis (HP:0000421)2.98684187
50Autoimmune thrombocytopenia (HP:0001973)2.97646264
51Chronic diarrhea (HP:0002028)2.93509195
52Gingivitis (HP:0000230)2.90226255
53Encephalitis (HP:0002383)2.89574788
54Hypoproteinemia (HP:0003075)2.89206713
55Bronchitis (HP:0012387)2.82947760
56Urticaria (HP:0001025)2.82665974
57Lymphoma (HP:0002665)2.82138741
58Abnormality of the fingertips (HP:0001211)2.81222939
59IgA deficiency (HP:0002720)2.74107169
60Chronic sinusitis (HP:0011109)2.73737518
61Hemoptysis (HP:0002105)2.72026524
62Aplastic anemia (HP:0001915)2.71951060
63Leukocytosis (HP:0001974)2.71599564
64Joint swelling (HP:0001386)2.70516988
65Eczematoid dermatitis (HP:0000976)2.70082997
66Increased IgM level (HP:0003496)2.68331207
67Petechiae (HP:0000967)2.64877651
68Granulocytopenia (HP:0001913)2.61175956
69Eosinophilia (HP:0001880)2.59437967
70Pustule (HP:0200039)2.58951206
71Arterial thrombosis (HP:0004420)2.58527192
72Hypoplasia of the thymus (HP:0000778)2.55137004
73Cellulitis (HP:0100658)2.53760910
74Microcytic anemia (HP:0001935)2.50444013
75Hypochromic anemia (HP:0001931)2.48654393
76Reticulocytopenia (HP:0001896)2.45301103
77Amaurosis fugax (HP:0100576)2.44148162
78Pulmonary infiltrates (HP:0002113)2.43753773
79Anorexia (HP:0002039)2.43238538
80Poikiloderma (HP:0001029)2.43004657
81Recurrent skin infections (HP:0001581)2.40860134
82Osteomyelitis (HP:0002754)2.39098415
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37911630
84Abnormality of cells of the erythroid lineage (HP:0012130)2.34260338
85Keratoconjunctivitis sicca (HP:0001097)2.33154849
86Entropion (HP:0000621)2.27414640
87Abnormality of the pleura (HP:0002103)2.27087018
88Gangrene (HP:0100758)2.27040577
89Type 2 muscle fiber atrophy (HP:0003554)2.26537706
90Muscle fiber atrophy (HP:0100295)2.23830339
91Hypochromic microcytic anemia (HP:0004840)2.23413812
92Chest pain (HP:0100749)2.22905578
93Increased IgE level (HP:0003212)2.22469261
94Emphysema (HP:0002097)2.22115858
95Mediastinal lymphadenopathy (HP:0100721)2.21531866
96Pulmonary embolism (HP:0002204)2.21517431
97Hypergammaglobulinemia (HP:0010702)2.21047511
98Recurrent bacterial skin infections (HP:0005406)2.19790335
99Basal cell carcinoma (HP:0002671)2.19349970
100Purpura (HP:0000979)2.18103778
101Abnormal number of erythroid precursors (HP:0012131)2.17784856
102Sepsis (HP:0100806)2.16379238
103Abnormality of the prostate (HP:0008775)2.14090129
104Abnormal platelet function (HP:0011869)2.13448035
105Impaired platelet aggregation (HP:0003540)2.13448035
106Abnormality of DNA repair (HP:0003254)2.11044165
107Keratoconjunctivitis (HP:0001096)2.10876757
108Glomerulopathy (HP:0100820)2.10746853
109Premature loss of primary teeth (HP:0006323)2.09136855
110Episodic fever (HP:0001954)2.09125727
111Acute myeloid leukemia (HP:0004808)2.07327399
112Interstitial pulmonary disease (HP:0006530)2.06993436
113Hematochezia (HP:0002573)2.04486841
114Papilledema (HP:0001085)2.03309025
115Papilloma (HP:0012740)2.03203747
116Verrucae (HP:0200043)2.03203747
117Vertigo (HP:0002321)2.02457397
118Recurrent otitis media (HP:0000403)1.99811593
119Abnormality of the endocardium (HP:0004306)1.99679334
120Fatigue (HP:0012378)1.98912238
121Gingival bleeding (HP:0000225)1.96922507
122Hemiplegia (HP:0002301)1.96850127
123Keratitis (HP:0000491)1.96065699
124Skin ulcer (HP:0200042)1.94794657
125Viral hepatitis (HP:0006562)1.92067583
126Acute hepatic failure (HP:0006554)1.88121576
127Stomach cancer (HP:0012126)1.86355444
128Abnormality of the peritoneum (HP:0002585)1.86273278
129Arthralgia (HP:0002829)1.85716021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.21402698
2TXK4.50906549
3RIPK43.54836171
4IKBKE2.97978274
5KDR2.75268081
6JAK32.71624633
7KIT2.52528616
8ZAP702.51021707
9NLK2.46534033
10PRPF4B2.46255937
11TIE12.45574486
12TEC2.44864061
13TGFBR22.43898851
14ITK2.41273017
15FGFR42.34213770
16TYK22.25698774
17TBK12.25440706
18TGFBR12.24521622
19MAP3K142.16947860
20BTK2.06452280
21LCK1.72384443
22FLT31.70275256
23STK101.68232991
24JAK11.66507567
25SYK1.56481364
26FGFR31.48825978
27IKBKB1.46707930
28FGR1.45875183
29TNIK1.45867847
30GRK61.43992257
31NME21.40332528
32CSF1R1.38697241
33MAP2K31.34941130
34MAP3K131.27201943
35HCK1.23448586
36BLK1.22955188
37MAP3K101.21178392
38CSK1.13735449
39MST41.09732790
40LRRK21.08182125
41MAP3K121.06950453
42TESK21.05417439
43EEF2K1.02813784
44LYN1.02574112
45MAP2K61.01095347
46CAMKK21.00131343
47MAP3K110.99488515
48FES0.98633360
49PIM10.96830456
50MAP3K30.95943924
51IRAK40.94992389
52BMPR20.92748469
53CLK10.91278554
54SIK20.88029190
55CHUK0.86810098
56ACVR1B0.86618596
57SIK30.84926297
58MUSK0.84661238
59CAMKK10.83805484
60PRKCH0.83123141
61MARK30.80652326
62MAP3K10.76801929
63MAP2K20.76572161
64RPS6KA40.75749102
65PRKCQ0.72330623
66PKN20.71543089
67TAOK10.71301441
68TNK20.68302790
69STK160.67619353
70FYN0.66932152
71EPHA30.66655700
72YES10.66124704
73ADRBK20.65256484
74MAPK120.63694305
75TRIB30.63379751
76CDC42BPA0.62925640
77PRKG20.61727812
78MAP3K70.61573695
79JAK20.60248807
80EPHB10.58531731
81HIPK20.58290358
82MAPKAPK30.56284553
83SMG10.55296184
84MYLK0.53599391
85ERN10.52842578
86MAPK70.52704326
87PTK2B0.52107952
88PASK0.52013325
89IRAK30.51887425
90KSR20.51003913
91PDPK10.50735583
92RPS6KA50.49797871
93PRKD20.49282515
94GRK70.46493853
95TLK10.46127234
96PIK3CG0.44790937
97CDK90.44400563
98MAPK40.44048154
99MATK0.43871058
100GRK10.43805429
101RPS6KB20.43220124
102MAP3K60.42682981
103CDK60.40093079
104IGF1R0.38531659
105MARK20.38310521
106RET0.38181122
107PIM20.36890063
108STK110.35899135
109TTN0.35779065
110NUAK10.35144794
111MAPKAPK20.34715614
112MAPK110.34132693
113TAOK20.32567913
114TRPM70.32230696
115PDK10.32090031
116RPS6KL10.30790252
117RPS6KC10.30790252
118MAPK30.30158566
119SGK30.29911493
120STK380.29623244
121RIPK10.28867285
122CAMK10.27723132
123NEK90.27465421
124STK40.27121820
125RPS6KA60.25856422
126ABL10.25557859
127PRKD10.24880080
128INSR0.24614974
129DYRK1B0.22381741
130CDK40.22330531
131VRK10.22189120
132PTK60.21921953
133MKNK10.21402219
134IRAK10.21175131
135TAOK30.20910953
136BRD40.20412785
137CDK190.20268152

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.46410436
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.84621027
3T cell receptor signaling pathway_Homo sapiens_hsa046602.77802636
4Ribosome_Homo sapiens_hsa030102.74334864
5Measles_Homo sapiens_hsa051622.70831656
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.69456406
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.66892359
8Hematopoietic cell lineage_Homo sapiens_hsa046402.54835512
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53301695
10B cell receptor signaling pathway_Homo sapiens_hsa046622.45730407
11Allograft rejection_Homo sapiens_hsa053302.38172045
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35557940
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.19052094
14Antigen processing and presentation_Homo sapiens_hsa046122.16905138
15Graft-versus-host disease_Homo sapiens_hsa053322.02168127
16Leishmaniasis_Homo sapiens_hsa051401.96490939
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.90043715
18Osteoclast differentiation_Homo sapiens_hsa043801.89890554
19Herpes simplex infection_Homo sapiens_hsa051681.83684312
20Autoimmune thyroid disease_Homo sapiens_hsa053201.57098190
21Viral myocarditis_Homo sapiens_hsa054161.51776230
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.40815157
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38899966
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33404966
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31308410
26Platelet activation_Homo sapiens_hsa046111.31027497
27Malaria_Homo sapiens_hsa051441.30036270
28Shigellosis_Homo sapiens_hsa051311.29282959
29Hepatitis B_Homo sapiens_hsa051611.28978881
30Toxoplasmosis_Homo sapiens_hsa051451.27836265
31Acute myeloid leukemia_Homo sapiens_hsa052211.26175262
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25697405
33Influenza A_Homo sapiens_hsa051641.24446691
34Chemokine signaling pathway_Homo sapiens_hsa040621.17257617
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15951224
36Non-homologous end-joining_Homo sapiens_hsa034501.13708350
37TNF signaling pathway_Homo sapiens_hsa046681.12028137
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10335527
39Base excision repair_Homo sapiens_hsa034101.09406378
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07382485
41DNA replication_Homo sapiens_hsa030301.00860221
42Apoptosis_Homo sapiens_hsa042100.96118901
43HTLV-I infection_Homo sapiens_hsa051660.96096537
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95741622
45Epstein-Barr virus infection_Homo sapiens_hsa051690.91429995
46Hepatitis C_Homo sapiens_hsa051600.90700022
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90247784
48Spliceosome_Homo sapiens_hsa030400.88831541
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87515369
50Phagosome_Homo sapiens_hsa041450.87301758
51Legionellosis_Homo sapiens_hsa051340.87110830
52RNA degradation_Homo sapiens_hsa030180.84027521
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83421267
54Asthma_Homo sapiens_hsa053100.81296409
55Mismatch repair_Homo sapiens_hsa034300.79854402
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.78618257
57Notch signaling pathway_Homo sapiens_hsa043300.73992459
58Pertussis_Homo sapiens_hsa051330.73355595
59Type I diabetes mellitus_Homo sapiens_hsa049400.70705365
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69988768
61African trypanosomiasis_Homo sapiens_hsa051430.69377499
62Pancreatic cancer_Homo sapiens_hsa052120.69352876
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69317615
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67614254
65Chronic myeloid leukemia_Homo sapiens_hsa052200.67504897
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67428542
67Nucleotide excision repair_Homo sapiens_hsa034200.66167815
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65362465
69Prolactin signaling pathway_Homo sapiens_hsa049170.64832667
70Salmonella infection_Homo sapiens_hsa051320.63944929
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.62244814
72Viral carcinogenesis_Homo sapiens_hsa052030.61970308
73Staphylococcus aureus infection_Homo sapiens_hsa051500.61220635
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60138587
75p53 signaling pathway_Homo sapiens_hsa041150.59823379
76Renal cell carcinoma_Homo sapiens_hsa052110.58602563
77Fanconi anemia pathway_Homo sapiens_hsa034600.58127022
78Insulin resistance_Homo sapiens_hsa049310.57733117
79Pyrimidine metabolism_Homo sapiens_hsa002400.57611486
80Homologous recombination_Homo sapiens_hsa034400.57400824
81RNA polymerase_Homo sapiens_hsa030200.57393365
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56522190
83Dorso-ventral axis formation_Homo sapiens_hsa043200.55655083
84Tuberculosis_Homo sapiens_hsa051520.55286808
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55069400
86Choline metabolism in cancer_Homo sapiens_hsa052310.54933780
87VEGF signaling pathway_Homo sapiens_hsa043700.52908591
88Thyroid cancer_Homo sapiens_hsa052160.52156983
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51854757
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50808378
91Rheumatoid arthritis_Homo sapiens_hsa053230.50730532
92Colorectal cancer_Homo sapiens_hsa052100.50677732
93Other glycan degradation_Homo sapiens_hsa005110.50500479
94Small cell lung cancer_Homo sapiens_hsa052220.50112002
95Basal transcription factors_Homo sapiens_hsa030220.49313475
96Endometrial cancer_Homo sapiens_hsa052130.49151062
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.47366428
98GnRH signaling pathway_Homo sapiens_hsa049120.47013845
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46630376
100Inositol phosphate metabolism_Homo sapiens_hsa005620.46364348
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.45745878
102Regulation of autophagy_Homo sapiens_hsa041400.44824344
103mTOR signaling pathway_Homo sapiens_hsa041500.41875730
104Caffeine metabolism_Homo sapiens_hsa002320.40568689
105Lysosome_Homo sapiens_hsa041420.40041241
106Ras signaling pathway_Homo sapiens_hsa040140.39009747
107Rap1 signaling pathway_Homo sapiens_hsa040150.37696013
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.37355441
109Long-term potentiation_Homo sapiens_hsa047200.35067227
110Prostate cancer_Homo sapiens_hsa052150.34697369
111Pathways in cancer_Homo sapiens_hsa052000.33634340
112ABC transporters_Homo sapiens_hsa020100.33583117
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33200027
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32595635
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32449722
116HIF-1 signaling pathway_Homo sapiens_hsa040660.29962570
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29601197
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29542677
119Amoebiasis_Homo sapiens_hsa051460.28599136
120FoxO signaling pathway_Homo sapiens_hsa040680.28343301
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27910825
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27216054
123Purine metabolism_Homo sapiens_hsa002300.25892816
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.21024164
125Endocytosis_Homo sapiens_hsa041440.20934364
126Non-small cell lung cancer_Homo sapiens_hsa052230.20893011
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20820500
128MAPK signaling pathway_Homo sapiens_hsa040100.19178398

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »