GIMAP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.00409629
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.95717608
3negative regulation of cell killing (GO:0031342)7.95717608
4positive regulation of gamma-delta T cell activation (GO:0046645)7.80192767
5negative thymic T cell selection (GO:0045060)7.77824620
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.43820077
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.43820077
8antigen processing and presentation of endogenous antigen (GO:0019883)6.88699936
9positive thymic T cell selection (GO:0045059)6.66811026
10regulation of isotype switching to IgG isotypes (GO:0048302)6.54874882
11thymic T cell selection (GO:0045061)6.35269081
12cellular response to interleukin-15 (GO:0071350)6.26348903
13regulation of gamma-delta T cell differentiation (GO:0045586)6.18449934
14positive T cell selection (GO:0043368)6.14155538
15response to interleukin-15 (GO:0070672)6.06380204
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.98214850
17T cell migration (GO:0072678)5.91698900
18interferon-gamma production (GO:0032609)5.89928547
19T cell selection (GO:0045058)5.79454282
20regulation of B cell receptor signaling pathway (GO:0050855)5.74936803
21regulation of gamma-delta T cell activation (GO:0046643)5.58640778
22regulation of T cell tolerance induction (GO:0002664)5.41992484
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.17199250
24positive regulation of natural killer cell mediated immunity (GO:0002717)5.11525365
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.11525365
26regulation of natural killer cell mediated immunity (GO:0002715)5.05928085
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.05928085
28leukocyte aggregation (GO:0070486)5.03487073
29T cell costimulation (GO:0031295)4.97078513
30lymphocyte costimulation (GO:0031294)4.90140786
31T cell receptor signaling pathway (GO:0050852)4.89399900
32regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.68615471
33regulation of alpha-beta T cell proliferation (GO:0046640)4.67580192
34antigen receptor-mediated signaling pathway (GO:0050851)4.53267518
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.44377312
36positive regulation of alpha-beta T cell proliferation (GO:0046641)4.43995886
37positive regulation of tolerance induction (GO:0002645)4.41997798
38B cell receptor signaling pathway (GO:0050853)4.29727891
39positive regulation of isotype switching (GO:0045830)4.20562867
40mast cell activation (GO:0045576)4.19002712
41regulation of T cell receptor signaling pathway (GO:0050856)4.15760406
42regulation of leukocyte mediated cytotoxicity (GO:0001910)4.15072204
43activated T cell proliferation (GO:0050798)4.12329058
44cytidine metabolic process (GO:0046087)4.11562390
45cytidine catabolic process (GO:0006216)4.11562390
46cytidine deamination (GO:0009972)4.11562390
47tolerance induction (GO:0002507)4.10952876
48positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.04491122
49regulation of response to tumor cell (GO:0002834)4.01898195
50positive regulation of response to tumor cell (GO:0002836)4.01898195
51positive regulation of immune response to tumor cell (GO:0002839)4.01898195
52regulation of immune response to tumor cell (GO:0002837)4.01898195
53negative regulation of T cell mediated immunity (GO:0002710)3.99896598
54regulation of activation of Janus kinase activity (GO:0010533)3.97690165
55regulation of regulatory T cell differentiation (GO:0045589)3.97564961
56regulation of tolerance induction (GO:0002643)3.97116930
57positive regulation of T cell mediated cytotoxicity (GO:0001916)3.94656409
58regulation of interleukin-2 biosynthetic process (GO:0045076)3.90130607
59regulation of cell killing (GO:0031341)3.89268923
60positive regulation of immunoglobulin mediated immune response (GO:0002891)3.87431455
61positive regulation of B cell mediated immunity (GO:0002714)3.87431455
62regulation of interleukin-12 biosynthetic process (GO:0045075)3.83018882
63regulation of isotype switching (GO:0045191)3.80768327
64pyrimidine ribonucleoside catabolic process (GO:0046133)3.79496946
65negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.77095970
66positive regulation of immunoglobulin production (GO:0002639)3.76990898
67positive regulation of cell killing (GO:0031343)3.76458016
68regulation of B cell differentiation (GO:0045577)3.73559523
69positive regulation of DNA recombination (GO:0045911)3.71370716
70positive regulation of interleukin-2 production (GO:0032743)3.66192202
71negative regulation of leukocyte mediated immunity (GO:0002704)3.66174966
72regulation of immunoglobulin mediated immune response (GO:0002889)3.65751155
73immunoglobulin mediated immune response (GO:0016064)3.64632958
74regulation of response to interferon-gamma (GO:0060330)3.64354813
75regulation of B cell mediated immunity (GO:0002712)3.60636803
76positive regulation of humoral immune response (GO:0002922)3.59452681
77regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.56914147
78positive regulation of B cell differentiation (GO:0045579)3.56705796
79type I interferon signaling pathway (GO:0060337)3.56297188
80cellular response to type I interferon (GO:0071357)3.56297188
81negative regulation of T cell receptor signaling pathway (GO:0050860)3.50795248
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.50379923
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49714772
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45457365
85DNA deamination (GO:0045006)3.45015174
86antigen processing and presentation via MHC class Ib (GO:0002475)3.44365360
87T cell differentiation (GO:0030217)3.44129554
88sequestering of actin monomers (GO:0042989)3.43560984
89lymphocyte migration (GO:0072676)3.41528576
90regulation of immunoglobulin production (GO:0002637)3.40235154
91dendritic cell chemotaxis (GO:0002407)3.38391867
92Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38190596
93immune response-activating cell surface receptor signaling pathway (GO:0002429)3.36691388
94negative regulation of phagocytosis (GO:0050765)3.36498915
95leukocyte cell-cell adhesion (GO:0007159)3.36257080
96positive regulation of calcium-mediated signaling (GO:0050850)3.36227385
97negative regulation of lymphocyte mediated immunity (GO:0002707)3.32343271
98cellular defense response (GO:0006968)3.28289468
99natural killer cell activation (GO:0030101)3.26238085
100T cell activation (GO:0042110)3.24964289
101T cell homeostasis (GO:0043029)3.23789677
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23348489
103response to interferon-beta (GO:0035456)3.22930534
104neutrophil activation involved in immune response (GO:0002283)3.21221925
105regulation of T cell mediated cytotoxicity (GO:0001914)3.21057109
106positive regulation of granulocyte differentiation (GO:0030854)3.18456217
107neutrophil activation (GO:0042119)3.17193150
108heterotypic cell-cell adhesion (GO:0034113)3.16985919
109mast cell degranulation (GO:0043303)3.16788521
110mast cell activation involved in immune response (GO:0002279)3.16788521
111leukocyte degranulation (GO:0043299)3.16270736
112negative regulation of T cell apoptotic process (GO:0070233)3.15829241
113negative regulation of B cell proliferation (GO:0030889)3.10538149
114detection of bacterium (GO:0016045)3.10023824
115negative regulation of viral genome replication (GO:0045071)3.09960236
116alpha-beta T cell activation (GO:0046631)3.09631523
117detection of other organism (GO:0098543)3.08751915
118regulation of lymphocyte mediated immunity (GO:0002706)3.08711722
119granulocyte activation (GO:0036230)3.07903417
120positive regulation of T cell mediated immunity (GO:0002711)3.06758974
121myeloid cell activation involved in immune response (GO:0002275)3.06003183
122regulation of T cell mediated immunity (GO:0002709)3.05716276
123dendritic cell migration (GO:0036336)3.04657518
124B cell mediated immunity (GO:0019724)3.03791013
125lymphocyte chemotaxis (GO:0048247)3.03457497
126positive regulation of lymphocyte mediated immunity (GO:0002708)3.02973578
127alpha-beta T cell differentiation (GO:0046632)3.01482410
128regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00191597
129T cell proliferation (GO:0042098)2.99525872
130positive regulation of T cell activation (GO:0050870)2.97299212
131regulation of defense response to virus by virus (GO:0050690)2.97129693
132ribosomal small subunit assembly (GO:0000028)2.94120634
133interferon-gamma-mediated signaling pathway (GO:0060333)2.90726561
134response to type I interferon (GO:0034340)2.89772457
135lymphocyte homeostasis (GO:0002260)2.89160957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.73842519
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.94068112
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.59498775
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.43430248
5E2F7_22180533_ChIP-Seq_HELA_Human4.02518214
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.75066349
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.64094037
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63390527
9RUNX_20019798_ChIP-Seq_JUKART_Human3.60121827
10MYB_26560356_Chip-Seq_TH2_Human3.36677303
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.36567670
12MYC_22102868_ChIP-Seq_BL_Human3.28461955
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.20289045
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19519659
15MAF_26560356_Chip-Seq_TH1_Human2.93434209
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.86647554
17MYB_26560356_Chip-Seq_TH1_Human2.74695379
18UTX_26944678_Chip-Seq_JUKART_Human2.59008115
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45115132
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34529709
21VDR_21846776_ChIP-Seq_THP-1_Human2.12838734
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09466090
23MAF_26560356_Chip-Seq_TH2_Human2.08094003
24SPI1_23547873_ChIP-Seq_NB4_Human2.07669567
25GATA3_27048872_Chip-Seq_THYMUS_Human2.07584352
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00940701
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00079550
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.97210193
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.95372245
30* NOTCH1_21737748_ChIP-Seq_TLL_Human1.91188820
31SCL_19346495_ChIP-Seq_HPC-7_Human1.84495486
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79881791
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76035398
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75391857
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69051347
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68616775
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67171654
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66960647
39TCF7_22412390_ChIP-Seq_EML_Mouse1.61895030
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.61733734
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61299719
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60414798
43VDR_24763502_ChIP-Seq_THP-1_Human1.59860893
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.51987318
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48466524
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47338781
47CIITA_25753668_ChIP-Seq_RAJI_Human1.47299514
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42144473
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41639479
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40623453
51VDR_23849224_ChIP-Seq_CD4+_Human1.40370031
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38701842
53GATA3_26560356_Chip-Seq_TH2_Human1.36648704
54FOXP3_21729870_ChIP-Seq_TREG_Human1.35141709
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34649167
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32873505
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32364676
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.31520898
59SPI1_23127762_ChIP-Seq_K562_Human1.29639758
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28908710
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26218898
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25940100
63KDM2B_26808549_Chip-Seq_DND41_Human1.24148288
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20385803
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19733752
66BCL6_27268052_Chip-Seq_Bcells_Human1.15724016
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13304062
68PU_27001747_Chip-Seq_BMDM_Mouse1.13241470
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12564303
70VDR_24787735_ChIP-Seq_THP-1_Human1.11872538
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07635606
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06397564
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05817018
74GATA1_22025678_ChIP-Seq_K562_Human1.05569580
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05085043
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02746934
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.01320245
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99960373
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99326935
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98241102
81GABP_17652178_ChIP-ChIP_JURKAT_Human0.97549885
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96206088
83ELK1_19687146_ChIP-ChIP_HELA_Human0.95523214
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95038026
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93066607
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92565493
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91977497
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91000823
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90614901
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.89620857
91* GATA3_26560356_Chip-Seq_TH1_Human0.86550331
92* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86525364
93GATA1_19941826_ChIP-Seq_K562_Human0.86212956
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84115528
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.83741781
96EST1_17652178_ChIP-ChIP_JURKAT_Human0.83619362
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83354474
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82521843
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82477516
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.80943556
101BCOR_27268052_Chip-Seq_Bcells_Human0.80880882
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80826490
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80578037
104SPI1_20517297_ChIP-Seq_HL60_Human0.80453237
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80214587
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79129033
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78697945
108* P300_27268052_Chip-Seq_Bcells_Human0.78652980
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78202811
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77495412
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.77018452
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76987272
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76375773
114XRN2_22483619_ChIP-Seq_HELA_Human0.76339643
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76315272
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.74538072
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74074535
118SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74051178
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73428175
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.73137531
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.72822608
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72486014
123SMRT_27268052_Chip-Seq_Bcells_Human0.72235255
124EGR1_19032775_ChIP-ChIP_M12_Human0.71905690
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71427545
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.70924015
127NCOR1_26117541_ChIP-Seq_K562_Human0.66218533
128RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65810086
129ETS1_22383799_ChIP-Seq_G1ME_Mouse0.64526739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.43930982
2MP0003763_abnormal_thymus_physiology5.27021196
3MP0001835_abnormal_antigen_presentation3.95260487
4MP0001800_abnormal_humoral_immune3.66373495
5MP0000685_abnormal_immune_system3.53671531
6MP0001790_abnormal_immune_system3.30152799
7MP0005387_immune_system_phenotype3.30152799
8MP0002420_abnormal_adaptive_immunity3.18598653
9MP0005000_abnormal_immune_tolerance3.13190551
10MP0001819_abnormal_immune_cell3.12635245
11MP0002166_altered_tumor_susceptibility3.05568047
12MP0009785_altered_susceptibility_to3.04599666
13MP0009333_abnormal_splenocyte_physiolog3.04082806
14MP0002723_abnormal_immune_serum3.02217257
15MP0002398_abnormal_bone_marrow2.99868442
16MP0002452_abnormal_antigen_presenting2.91765088
17MP0006082_CNS_inflammation2.75320815
18MP0005025_abnormal_response_to2.66752122
19MP0000716_abnormal_immune_system2.66146669
20MP0002006_tumorigenesis2.50936967
21MP0000703_abnormal_thymus_morphology2.50136315
22MP0001873_stomach_inflammation2.45477922
23MP0002405_respiratory_system_inflammati2.41938412
24MP0000689_abnormal_spleen_morphology2.41828095
25MP0002722_abnormal_immune_system2.40690509
26MP0002429_abnormal_blood_cell2.18175846
27MP0002148_abnormal_hypersensitivity_rea2.13210353
28MP0010155_abnormal_intestine_physiology2.08187783
29MP0002396_abnormal_hematopoietic_system2.07264354
30MP0003724_increased_susceptibility_to2.05220540
31MP0003436_decreased_susceptibility_to2.02691989
32MP0004947_skin_inflammation2.01735391
33MP0003866_abnormal_defecation2.00545984
34MP0002933_joint_inflammation2.00042024
35MP0002419_abnormal_innate_immunity1.95263580
36MP0003300_gastrointestinal_ulcer1.87020990
37MP0000858_altered_metastatic_potential1.81782988
38MP0001845_abnormal_inflammatory_respons1.78076320
39MP0005464_abnormal_platelet_physiology1.69501265
40MP0003448_altered_tumor_morphology1.54947625
41MP0003303_peritoneal_inflammation1.41217124
42MP0001853_heart_inflammation1.36142650
43MP0002009_preneoplasia1.32201063
44MP0004808_abnormal_hematopoietic_stem1.30603744
45MP0003045_fibrosis1.28561765
46MP0002019_abnormal_tumor_incidence1.23261108
47MP0004381_abnormal_hair_follicle1.21764730
48MP0005075_abnormal_melanosome_morpholog1.21677787
49MP0004510_myositis1.19291127
50MP0008469_abnormal_protein_level1.19044013
51MP0003828_pulmonary_edema1.18293979
52MP0000490_abnormal_crypts_of1.15956980
53MP0000465_gastrointestinal_hemorrhage1.12873092
54MP0005310_abnormal_salivary_gland1.10437154
55MP0004883_abnormal_blood_vessel1.07532454
56MP0003646_muscle_fatigue1.05995002
57MP0004130_abnormal_muscle_cell1.00468382
58MP0002132_abnormal_respiratory_system0.99801994
59MP0002277_abnormal_respiratory_mucosa0.98271296
60MP0008057_abnormal_DNA_replication0.93098333
61MP0001533_abnormal_skeleton_physiology0.92978802
62MP0002998_abnormal_bone_remodeling0.87749288
63MP0003077_abnormal_cell_cycle0.84011897
64MP0001851_eye_inflammation0.83503950
65MP0003690_abnormal_glial_cell0.81930710
66MP0006054_spinal_hemorrhage0.81440579
67MP0003693_abnormal_embryo_hatching0.81163494
68MP0009763_increased_sensitivity_to0.80875500
69MP0001545_abnormal_hematopoietic_system0.80486830
70MP0005397_hematopoietic_system_phenotyp0.80486830
71MP0003191_abnormal_cellular_cholesterol0.77687769
72MP0010094_abnormal_chromosome_stability0.76466964
73MP0000604_amyloidosis0.73353891
74MP0003075_altered_response_to0.73262302
75MP0004957_abnormal_blastocyst_morpholog0.72328498
76MP0002136_abnormal_kidney_physiology0.68498764
77MP0005164_abnormal_response_to0.67276760
78MP0009765_abnormal_xenobiotic_induced0.66418474
79MP0005023_abnormal_wound_healing0.66355869
80MP0010352_gastrointestinal_tract_polyps0.65632869
81MP0000343_altered_response_to0.65244207
82MP0001986_abnormal_taste_sensitivity0.64690098
83MP0005174_abnormal_tail_pigmentation0.63973752
84MP0005166_decreased_susceptibility_to0.62446431
85MP0002163_abnormal_gland_morphology0.59707439
86MP0008007_abnormal_cellular_replicative0.58169633
87MP0000477_abnormal_intestine_morphology0.57863476
88MP0005167_abnormal_blood-brain_barrier0.57712427
89MP0001919_abnormal_reproductive_system0.57416037
90MP0010234_abnormal_vibrissa_follicle0.57260245
91MP0008260_abnormal_autophagy0.56383744
92MP0009764_decreased_sensitivity_to0.55880472
93MP0005390_skeleton_phenotype0.54834237
94MP0001765_abnormal_ion_homeostasis0.54243123
95MP0000609_abnormal_liver_physiology0.51869005
96MP0003183_abnormal_peptide_metabolism0.51385878
97MP0008058_abnormal_DNA_repair0.51292465
98MP0008874_decreased_physiological_sensi0.51264400
99MP0008873_increased_physiological_sensi0.51238057
100MP0003795_abnormal_bone_structure0.49399281
101MP0001191_abnormal_skin_condition0.49371621
102MP0003252_abnormal_bile_duct0.49145688
103MP0002693_abnormal_pancreas_physiology0.48704784
104MP0001663_abnormal_digestive_system0.46823520
105MP0002822_catalepsy0.46748238
106MP0000249_abnormal_blood_vessel0.45653158
107MP0000920_abnormal_myelination0.45184784
108MP0005381_digestive/alimentary_phenotyp0.44714482
109MP0002095_abnormal_skin_pigmentation0.44697927
110MP0001243_abnormal_dermal_layer0.44083027
111MP0000015_abnormal_ear_pigmentation0.42575559
112MP0000313_abnormal_cell_death0.41927495
113MP0002083_premature_death0.40854619
114MP0009642_abnormal_blood_homeostasis0.40363419
115MP0001348_abnormal_lacrimal_gland0.40225838
116MP0008872_abnormal_physiological_respon0.38670101
117MP0003172_abnormal_lysosome_physiology0.37554501
118MP0003638_abnormal_response/metabolism_0.37224344
119MP0003111_abnormal_nucleus_morphology0.37007563
120MP0003453_abnormal_keratinocyte_physiol0.36632945
121MP0009278_abnormal_bone_marrow0.36629146
122MP0002138_abnormal_hepatobiliary_system0.35673469
123MP0009643_abnormal_urine_homeostasis0.35090133
124MP0005584_abnormal_enzyme/coenzyme_acti0.34781905
125MP0003787_abnormal_imprinting0.34164094
126MP0000367_abnormal_coat/_hair0.33961683
127MP0000598_abnormal_liver_morphology0.33395994
128MP0000350_abnormal_cell_proliferation0.33321005

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.28524833
2Abnormality of T cell number (HP:0011839)7.05768499
3Recurrent bronchitis (HP:0002837)6.09715634
4Abnormality of T cells (HP:0002843)5.34477282
5Chronic otitis media (HP:0000389)5.32334111
6IgM deficiency (HP:0002850)5.14336358
7Nasal polyposis (HP:0100582)5.09811096
8Elevated erythrocyte sedimentation rate (HP:0003565)5.03943487
9Severe combined immunodeficiency (HP:0004430)5.00178997
10Combined immunodeficiency (HP:0005387)4.99457169
11Myositis (HP:0100614)4.95369755
12IgG deficiency (HP:0004315)4.32337093
13Recurrent viral infections (HP:0004429)4.26252394
14Abnormality of the nasal mucosa (HP:0000433)4.21153317
15Lymphopenia (HP:0001888)4.15084256
16Agammaglobulinemia (HP:0004432)4.00886219
17Recurrent sinusitis (HP:0011108)4.00619794
18Panhypogammaglobulinemia (HP:0003139)4.00483570
19Abnormality of cells of the lymphoid lineage (HP:0012140)4.00124744
20Meningitis (HP:0001287)3.99812820
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.98322886
22Recurrent fungal infections (HP:0002841)3.82833580
23Encephalitis (HP:0002383)3.65113435
24Thyroiditis (HP:0100646)3.62956279
25Recurrent abscess formation (HP:0002722)3.61764680
26Abnormality of B cell number (HP:0010975)3.57794355
27B lymphocytopenia (HP:0010976)3.57794355
28Abnormality of T cell physiology (HP:0011840)3.57729275
29Optic neuritis (HP:0100653)3.54812403
30Retrobulbar optic neuritis (HP:0100654)3.54812403
31Pustule (HP:0200039)3.54002506
32Bronchitis (HP:0012387)3.52486304
33Vasculitis (HP:0002633)3.52310093
34Abnormality of eosinophils (HP:0001879)3.46587248
35Autoimmune hemolytic anemia (HP:0001890)3.44249987
36Chronic sinusitis (HP:0011109)3.42769513
37Stomatitis (HP:0010280)3.41307359
38Eczematoid dermatitis (HP:0000976)3.40719580
39Joint swelling (HP:0001386)3.37025438
40Recurrent cutaneous fungal infections (HP:0011370)3.34689747
41Chronic mucocutaneous candidiasis (HP:0002728)3.34689747
42Inflammation of the large intestine (HP:0002037)3.28283410
43Increased IgM level (HP:0003496)3.27500772
44Chronic diarrhea (HP:0002028)3.19253901
45Gastrointestinal inflammation (HP:0004386)3.18878803
46Recurrent gram-negative bacterial infections (HP:0005420)3.15373124
47Gastrointestinal stroma tumor (HP:0100723)3.12285918
48Orchitis (HP:0100796)3.10943690
49Leukocytosis (HP:0001974)3.04241325
50Autoimmune thrombocytopenia (HP:0001973)3.02444466
51Pulmonary infiltrates (HP:0002113)3.00026738
52IgA deficiency (HP:0002720)2.99142325
53Chronic obstructive pulmonary disease (HP:0006510)2.95920895
54Obstructive lung disease (HP:0006536)2.95920895
55Eosinophilia (HP:0001880)2.95881354
56Keratoconjunctivitis sicca (HP:0001097)2.94843165
57Abnormality of the fingertips (HP:0001211)2.94185251
58Lymphoma (HP:0002665)2.93627413
59Recurrent otitis media (HP:0000403)2.88769025
60Hypoproteinemia (HP:0003075)2.87217672
61Hemoptysis (HP:0002105)2.86248551
62Mediastinal lymphadenopathy (HP:0100721)2.83860260
63Thrombocytosis (HP:0001894)2.78846146
64Gastrointestinal infarctions (HP:0005244)2.77982602
65Recurrent bacterial skin infections (HP:0005406)2.77689659
66Verrucae (HP:0200043)2.75918711
67Papilloma (HP:0012740)2.75918711
68Stomach cancer (HP:0012126)2.75161935
69Colitis (HP:0002583)2.70491306
70Granulocytopenia (HP:0001913)2.68895303
71Spontaneous hematomas (HP:0007420)2.68820300
72Keratoconjunctivitis (HP:0001096)2.66602367
73Hypergammaglobulinemia (HP:0010702)2.64263809
74Recurrent skin infections (HP:0001581)2.61469463
75Emphysema (HP:0002097)2.60479164
76Abnormality of the prostate (HP:0008775)2.57547324
77Hemiplegia (HP:0002301)2.54507564
78Prolonged bleeding time (HP:0003010)2.54147293
79Arterial thrombosis (HP:0004420)2.54007396
80Hypochromic anemia (HP:0001931)2.52555548
81Urticaria (HP:0001025)2.51377225
82Pulmonary embolism (HP:0002204)2.45485983
83Gingivitis (HP:0000230)2.44756440
84Basal cell carcinoma (HP:0002671)2.43971456
85Increased IgE level (HP:0003212)2.37440279
86Chest pain (HP:0100749)2.26782044
87Anorexia (HP:0002039)2.25279694
88Cellulitis (HP:0100658)2.21507654
89Ureteral stenosis (HP:0000071)2.17226305
90Gangrene (HP:0100758)2.13666212
91Acute hepatic failure (HP:0006554)2.11306023
92Petechiae (HP:0000967)2.10871728
93Epistaxis (HP:0000421)2.10440706
94Glomerulopathy (HP:0100820)2.09988853
95Bronchiectasis (HP:0002110)2.08031871
96Restrictive lung disease (HP:0002091)2.07652967
97Skin rash (HP:0000988)2.02163315
98Aplastic anemia (HP:0001915)2.01722975
99Amaurosis fugax (HP:0100576)2.00946151
100Skin ulcer (HP:0200042)2.00789284
101Arthralgia (HP:0002829)1.97402885
102Abnormal platelet volume (HP:0011876)1.96589109
103Ureteral obstruction (HP:0006000)1.94751549
1043-Methylglutaconic aciduria (HP:0003535)1.93708212
105Polyneuropathy (HP:0001271)1.91671661
106Periodontitis (HP:0000704)1.91477958
107Sepsis (HP:0100806)1.91001198
108Keratitis (HP:0000491)1.90733495
109Increased serum ferritin (HP:0003281)1.85700616
110Hypoplasia of the thymus (HP:0000778)1.85281712
111Abnormality of the pleura (HP:0002103)1.83524313
112Abnormality of oral frenula (HP:0000190)1.82999289
113Abnormality of macrophages (HP:0004311)1.82418288
114Gingival bleeding (HP:0000225)1.81991717
115Microcytic anemia (HP:0001935)1.80679192
116Prostate neoplasm (HP:0100787)1.80231817
117Hepatitis (HP:0012115)1.79731990
118Pulmonary fibrosis (HP:0002206)1.79676038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.80840326
2MAP4K16.06574067
3ITK3.32883122
4RIPK42.93098527
5JAK32.90130939
6ZAP702.80615743
7STK102.67022154
8JAK12.64224889
9IKBKE2.58508790
10TYK22.48188321
11FGFR42.43380211
12GRK62.34573746
13MST42.33074850
14MAP3K142.21814563
15LCK2.06084594
16NLK1.93968968
17BLK1.91025402
18SYK1.87118990
19CAMKK21.83439169
20CSK1.82193707
21TBK11.81420414
22TEC1.74720176
23KIT1.69267548
24BTK1.68296463
25FGFR31.57544749
26IRAK41.52153332
27CLK11.45660332
28CAMKK11.40356211
29LRRK21.39487628
30NME21.37843837
31GRK71.35085028
32CSF1R1.34941225
33MAP3K131.34742673
34PRKCH1.28204655
35TESK21.24105560
36PRKCQ1.22550499
37HCK1.21673201
38IKBKB1.17023948
39MAP3K111.11774061
40LYN1.10624094
41FES1.07717323
42EEF2K1.02216281
43KDR1.00680926
44MARK30.98506266
45PIM10.95623183
46FGR0.94589383
47PTK2B0.86849302
48MAP3K100.86541239
49TNK20.78664170
50RPS6KA40.77230173
51MAP2K30.75708592
52LIMK10.75610768
53SIK20.73215752
54TGFBR20.69522710
55JAK20.68206192
56PIK3CG0.65638027
57MELK0.63707611
58CHUK0.63191319
59CDC42BPA0.62019799
60CDK40.61825215
61MAP3K120.58581569
62MAP2K60.56732527
63SIK30.56140951
64IRAK30.55047725
65MAPK110.53253888
66FLT30.52954887
67TESK10.51351790
68SCYL20.51325380
69TAOK30.51107865
70GRK50.49890336
71FYN0.49425984
72MAP3K30.49370183
73PKN20.47563939
74BMPR20.46512501
75PTK60.46030070
76MAPKAPK30.45840784
77EPHA30.45447345
78MAP3K70.45422762
79MAP3K10.43261494
80ALK0.42912416
81STK40.42889077
82PDK10.40827484
83IGF1R0.40661330
84INSR0.40535791
85PRKD20.38575091
86PASK0.38419462
87EPHB10.38082960
88ERN10.36318488
89MATK0.35840437
90PIK3CA0.35075016
91NUAK10.34993061
92HIPK20.33693972
93CDK80.32430898
94TLK10.32124309
95MAP2K20.31672976
96BCKDK0.31473360
97MAPK70.31424474
98ADRBK10.31093231
99IRAK10.30041066
100CDK60.29373013
101PRKCD0.28900981
102PDPK10.28714785
103CDC70.28697564
104MOS0.27978092
105TAOK10.26650452
106TSSK60.26169992
107STK240.25842924
108MAPK40.24838573
109NEK20.24040334
110ACVR1B0.23310955
111PDGFRB0.22155658
112CDK90.22147931
113MAPK30.21922420
114TGFBR10.21235530
115NEK90.21152898
116TTN0.21138429
117ADRBK20.20392431
118RPS6KA60.20300475
119ABL10.19816370
120MAP3K80.19308087
121RAF10.18744416
122MAPKAPK20.18237664
123MAPK120.18190914
124RPS6KA50.17895206
125TYRO30.16756303
126TRIB30.15304987
127CDK120.14583130
128PRPF4B0.14529206
129RPS6KB20.14416283

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.34412734
2Graft-versus-host disease_Homo sapiens_hsa053324.20897948
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.61437655
4T cell receptor signaling pathway_Homo sapiens_hsa046603.52738363
5Antigen processing and presentation_Homo sapiens_hsa046123.25550775
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.08591760
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.01649019
8Allograft rejection_Homo sapiens_hsa053302.97609183
9Measles_Homo sapiens_hsa051622.72238477
10Hematopoietic cell lineage_Homo sapiens_hsa046402.41816955
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.31610678
12Autoimmune thyroid disease_Homo sapiens_hsa053202.12947767
13B cell receptor signaling pathway_Homo sapiens_hsa046622.11468295
14Viral myocarditis_Homo sapiens_hsa054161.89876648
15Leishmaniasis_Homo sapiens_hsa051401.84335200
16Ribosome_Homo sapiens_hsa030101.79206135
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66609520
18Osteoclast differentiation_Homo sapiens_hsa043801.65274613
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.64621271
20Herpes simplex infection_Homo sapiens_hsa051681.51543768
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47739271
22Type I diabetes mellitus_Homo sapiens_hsa049401.44729016
23DNA replication_Homo sapiens_hsa030301.38304176
24Mismatch repair_Homo sapiens_hsa034301.36971761
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.30216162
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28527799
27Chemokine signaling pathway_Homo sapiens_hsa040621.22548798
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21353956
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19806412
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19008014
31Shigellosis_Homo sapiens_hsa051311.17244555
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10748957
33Non-homologous end-joining_Homo sapiens_hsa034501.10551668
34Toxoplasmosis_Homo sapiens_hsa051451.09245016
35Hepatitis B_Homo sapiens_hsa051611.05656890
36Influenza A_Homo sapiens_hsa051641.04714571
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03155110
38Base excision repair_Homo sapiens_hsa034101.01256421
39Apoptosis_Homo sapiens_hsa042100.95665351
40HTLV-I infection_Homo sapiens_hsa051660.91929733
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89773478
42Epstein-Barr virus infection_Homo sapiens_hsa051690.89687596
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87553946
44Malaria_Homo sapiens_hsa051440.85324763
45Acute myeloid leukemia_Homo sapiens_hsa052210.82169915
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82136411
47TNF signaling pathway_Homo sapiens_hsa046680.80299014
48Pancreatic cancer_Homo sapiens_hsa052120.79042781
49Platelet activation_Homo sapiens_hsa046110.77120812
50Legionellosis_Homo sapiens_hsa051340.76937230
51Proteasome_Homo sapiens_hsa030500.74745112
52Spliceosome_Homo sapiens_hsa030400.74328697
53Tuberculosis_Homo sapiens_hsa051520.73961601
54p53 signaling pathway_Homo sapiens_hsa041150.70344197
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68083027
56Colorectal cancer_Homo sapiens_hsa052100.66973106
57Nucleotide excision repair_Homo sapiens_hsa034200.65783247
58Phagosome_Homo sapiens_hsa041450.65580492
59Staphylococcus aureus infection_Homo sapiens_hsa051500.65325012
60Hepatitis C_Homo sapiens_hsa051600.64122739
61Asthma_Homo sapiens_hsa053100.63936474
62Regulation of autophagy_Homo sapiens_hsa041400.62955272
63Viral carcinogenesis_Homo sapiens_hsa052030.60777140
64Pertussis_Homo sapiens_hsa051330.60154712
65Salmonella infection_Homo sapiens_hsa051320.59801134
66VEGF signaling pathway_Homo sapiens_hsa043700.55462021
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55061939
68Homologous recombination_Homo sapiens_hsa034400.49257838
69RNA degradation_Homo sapiens_hsa030180.47051412
70Chronic myeloid leukemia_Homo sapiens_hsa052200.46534087
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45567643
72Linoleic acid metabolism_Homo sapiens_hsa005910.45290069
73Non-small cell lung cancer_Homo sapiens_hsa052230.43929855
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43794664
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41966449
76Rheumatoid arthritis_Homo sapiens_hsa053230.41913785
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.40937489
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39923421
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.39647934
80Caffeine metabolism_Homo sapiens_hsa002320.39636073
81Prolactin signaling pathway_Homo sapiens_hsa049170.38651102
82Endocytosis_Homo sapiens_hsa041440.37761655
83Arachidonic acid metabolism_Homo sapiens_hsa005900.36883960
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.36242711
85Small cell lung cancer_Homo sapiens_hsa052220.35847903
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35386021
87Systemic lupus erythematosus_Homo sapiens_hsa053220.35301679
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32792738
89Pentose phosphate pathway_Homo sapiens_hsa000300.31984685
90Notch signaling pathway_Homo sapiens_hsa043300.31698817
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31529291
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30891715
93African trypanosomiasis_Homo sapiens_hsa051430.29747324
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28876155
95Fanconi anemia pathway_Homo sapiens_hsa034600.28413581
96Cell cycle_Homo sapiens_hsa041100.27073022
97Insulin resistance_Homo sapiens_hsa049310.26170606
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25783865
99FoxO signaling pathway_Homo sapiens_hsa040680.25736098
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25130951
101Pyrimidine metabolism_Homo sapiens_hsa002400.22335965
102Ras signaling pathway_Homo sapiens_hsa040140.21705069
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.21365389
104Lysosome_Homo sapiens_hsa041420.21287335
105Other glycan degradation_Homo sapiens_hsa005110.20671588
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19992014
107mRNA surveillance pathway_Homo sapiens_hsa030150.18770655
108Inositol phosphate metabolism_Homo sapiens_hsa005620.17210865
109Choline metabolism in cancer_Homo sapiens_hsa052310.16266234
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15678341
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.14655998
112Protein export_Homo sapiens_hsa030600.14647680
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.13961583
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13889678
115Renin secretion_Homo sapiens_hsa049240.13817041
116Rap1 signaling pathway_Homo sapiens_hsa040150.13483915
117MAPK signaling pathway_Homo sapiens_hsa040100.13479338
118ABC transporters_Homo sapiens_hsa020100.11601239
119RNA transport_Homo sapiens_hsa030130.11475023
120Dorso-ventral axis formation_Homo sapiens_hsa043200.11024985
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.10922513
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10753251
123Phototransduction_Homo sapiens_hsa047440.10272073
124Glycerolipid metabolism_Homo sapiens_hsa005610.10168842
125Thyroid cancer_Homo sapiens_hsa052160.08185607
126Adherens junction_Homo sapiens_hsa045200.07879002
127RNA polymerase_Homo sapiens_hsa030200.07506942
128Prostate cancer_Homo sapiens_hsa052150.07189484

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