GIMAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.96376721
2negative T cell selection (GO:0043383)7.17842057
3negative thymic T cell selection (GO:0045060)7.02992141
4negative regulation of cell killing (GO:0031342)6.89388886
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.89388886
6positive thymic T cell selection (GO:0045059)6.79906198
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.76143635
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.76143635
9regulation of gamma-delta T cell differentiation (GO:0045586)6.60889934
10antigen processing and presentation of endogenous antigen (GO:0019883)6.47813548
11response to interleukin-15 (GO:0070672)6.40253625
12interferon-gamma production (GO:0032609)6.28312708
13positive T cell selection (GO:0043368)6.22504304
14cellular response to interleukin-15 (GO:0071350)6.15737276
15thymic T cell selection (GO:0045061)6.08629743
16regulation of gamma-delta T cell activation (GO:0046643)6.04865214
17regulation of isotype switching to IgG isotypes (GO:0048302)5.86663004
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.83672646
19T cell selection (GO:0045058)5.83240970
20T cell migration (GO:0072678)5.35995657
21regulation of T cell tolerance induction (GO:0002664)5.16190318
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.15695262
23regulation of B cell receptor signaling pathway (GO:0050855)5.10363924
24regulation of regulatory T cell differentiation (GO:0045589)4.96722146
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89824080
26positive regulation by organism of defense response of other organism involved in symbiotic interact4.89824080
27modulation by symbiont of host immune response (GO:0052553)4.89824080
28positive regulation by symbiont of host defense response (GO:0052509)4.89824080
29modulation by symbiont of host defense response (GO:0052031)4.89824080
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89824080
31regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.66076278
32detection of other organism (GO:0098543)4.63370493
33T cell receptor signaling pathway (GO:0050852)4.58094831
34leukocyte aggregation (GO:0070486)4.46499031
35T cell costimulation (GO:0031295)4.46420350
36negative regulation of T cell mediated immunity (GO:0002710)4.42665662
37lymphocyte costimulation (GO:0031294)4.40331378
38detection of bacterium (GO:0016045)4.37216933
39regulation of alpha-beta T cell proliferation (GO:0046640)4.36839727
40B cell receptor signaling pathway (GO:0050853)4.35370043
41antigen receptor-mediated signaling pathway (GO:0050851)4.34480347
42macrophage activation involved in immune response (GO:0002281)4.34121431
43positive regulation of tolerance induction (GO:0002645)4.30867182
44tolerance induction (GO:0002507)4.27181628
45neutrophil activation involved in immune response (GO:0002283)4.21056360
46regulation of B cell differentiation (GO:0045577)4.20651463
47negative regulation of interleukin-12 production (GO:0032695)4.19495937
48regulation of interleukin-12 biosynthetic process (GO:0045075)4.13116741
49positive regulation of interleukin-2 production (GO:0032743)4.12775179
50activated T cell proliferation (GO:0050798)4.03247854
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.02372720
52positive regulation of isotype switching (GO:0045830)3.95418157
53detection of external biotic stimulus (GO:0098581)3.94786426
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92332701
55regulation of tolerance induction (GO:0002643)3.87500423
56regulation of interleukin-2 biosynthetic process (GO:0045076)3.86492174
57cellular extravasation (GO:0045123)3.84486118
58detection of molecule of bacterial origin (GO:0032490)3.81581755
59immunoglobulin mediated immune response (GO:0016064)3.80359753
60regulation of isotype switching (GO:0045191)3.79978990
61positive regulation of humoral immune response (GO:0002922)3.77592490
62response to peptidoglycan (GO:0032494)3.75145887
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.68362536
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.66986386
65regulation of interferon-beta biosynthetic process (GO:0045357)3.63190164
66regulation of T cell receptor signaling pathway (GO:0050856)3.62565344
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.60709079
68regulation of natural killer cell mediated immunity (GO:0002715)3.60709079
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.60114620
70microglial cell activation (GO:0001774)3.58611678
71antigen processing and presentation via MHC class Ib (GO:0002475)3.57950647
72negative regulation of leukocyte mediated immunity (GO:0002704)3.54311757
73cellular response to type I interferon (GO:0071357)3.51784926
74type I interferon signaling pathway (GO:0060337)3.51784926
75positive regulation of DNA recombination (GO:0045911)3.50720362
76T cell homeostasis (GO:0043029)3.50634562
77macrophage activation (GO:0042116)3.48501027
78alpha-beta T cell activation (GO:0046631)3.48039716
79negative regulation of lymphocyte mediated immunity (GO:0002707)3.47445812
80NIK/NF-kappaB signaling (GO:0038061)3.42531247
81detection of biotic stimulus (GO:0009595)3.41022645
82positive regulation of B cell differentiation (GO:0045579)3.40487829
83positive regulation of immunoglobulin production (GO:0002639)3.40272482
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39021441
85response to host immune response (GO:0052572)3.39021441
86positive regulation of B cell mediated immunity (GO:0002714)3.36369646
87positive regulation of immunoglobulin mediated immune response (GO:0002891)3.36369646
88regulation of immunoglobulin mediated immune response (GO:0002889)3.35984352
89regulation of response to interferon-gamma (GO:0060330)3.34405404
90alpha-beta T cell differentiation (GO:0046632)3.34166377
91leukocyte cell-cell adhesion (GO:0007159)3.33562986
92positive regulation of natural killer cell mediated immunity (GO:0002717)3.32915711
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.32915711
94regulation of B cell mediated immunity (GO:0002712)3.32766401
95natural killer cell activation (GO:0030101)3.31055736
96respiratory burst (GO:0045730)3.30555658
97T cell differentiation (GO:0030217)3.30545912
98B cell proliferation (GO:0042100)3.28740129
99regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.27660523
100regulation of immunoglobulin production (GO:0002637)3.27353763
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27224076
102neutrophil activation (GO:0042119)3.26126288
103negative regulation of erythrocyte differentiation (GO:0045647)3.22486335
104lymphocyte homeostasis (GO:0002260)3.22377522
105regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21165716
106myeloid cell activation involved in immune response (GO:0002275)3.17970504
107mature B cell differentiation (GO:0002335)3.17950854
108response to host (GO:0075136)3.16738743
109response to host defenses (GO:0052200)3.16738743
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16738743
111interferon-gamma-mediated signaling pathway (GO:0060333)3.15999803
112regulation of leukocyte mediated cytotoxicity (GO:0001910)3.14548025
113immune response-activating cell surface receptor signaling pathway (GO:0002429)3.14166885
114regulation of interleukin-2 production (GO:0032663)3.13556185
115negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11408026
116regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09998802
117mast cell activation (GO:0045576)3.09891477
118regulation of B cell proliferation (GO:0030888)3.06604150
119T cell proliferation (GO:0042098)3.05444383
120positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.05157355
121positive regulation of B cell proliferation (GO:0030890)3.04062909
122leukocyte migration involved in inflammatory response (GO:0002523)3.03924493
123regulation of T cell mediated cytotoxicity (GO:0001914)3.02577146
124heterotypic cell-cell adhesion (GO:0034113)3.02272399
125negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.01865759
126lymph node development (GO:0048535)3.00666862
127regulation of alpha-beta T cell activation (GO:0046634)3.00500349
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.99746407
129granulocyte activation (GO:0036230)2.98247748
130cellular response to zinc ion (GO:0071294)2.97084355
131positive regulation of granulocyte differentiation (GO:0030854)2.96993773
132response to type I interferon (GO:0034340)2.96806947
133T-helper cell differentiation (GO:0042093)2.96673916
134CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.96673916
135B cell mediated immunity (GO:0019724)2.95904362
136response to muramyl dipeptide (GO:0032495)2.94061998
137production of molecular mediator involved in inflammatory response (GO:0002532)2.93039557
138regulation of cell killing (GO:0031341)2.92247165
139negative regulation of innate immune response (GO:0045824)2.90642839
140regulation of mast cell degranulation (GO:0043304)2.90476157
141T cell activation (GO:0042110)2.90391466
142positive regulation of B cell activation (GO:0050871)2.89792504
143lymphocyte migration (GO:0072676)2.88287700
144negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87946496
145positive regulation of T cell activation (GO:0050870)2.84593336
146myeloid dendritic cell activation (GO:0001773)2.84419489
147dendritic cell chemotaxis (GO:0002407)2.82930152
148neutrophil mediated immunity (GO:0002446)2.82560546
149positive regulation of mast cell activation (GO:0033005)2.82182632
150regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81341170
151positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81196224
152dendritic cell migration (GO:0036336)2.81032308
153negative regulation of type 2 immune response (GO:0002829)2.76526337
154germinal center formation (GO:0002467)2.76237896
155regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75031455
156regulation of antigen processing and presentation (GO:0002577)2.72846049
157myeloid leukocyte activation (GO:0002274)2.72009014
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70176010
159defense response to protozoan (GO:0042832)2.68651276
160positive regulation of interferon-alpha production (GO:0032727)2.67985419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.27878286
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.44351281
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.17803495
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.24687040
5RUNX_20019798_ChIP-Seq_JUKART_Human4.16599111
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.94638987
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.89790577
8MYC_22102868_ChIP-Seq_BL_Human3.64417215
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.62957338
10MYB_26560356_Chip-Seq_TH2_Human3.31222202
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30700219
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.24484962
13MYB_26560356_Chip-Seq_TH1_Human2.93815903
14MAF_26560356_Chip-Seq_TH1_Human2.93326458
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86904933
16UTX_26944678_Chip-Seq_JUKART_Human2.64560465
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.56421225
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.51323046
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45204358
20VDR_21846776_ChIP-Seq_THP-1_Human2.34309152
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.33055821
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27738060
23SCL_19346495_ChIP-Seq_HPC-7_Human2.23777618
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22547912
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.19371675
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15987377
27GATA3_27048872_Chip-Seq_THYMUS_Human2.09699094
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09333164
29TCF7_22412390_ChIP-Seq_EML_Mouse2.08077149
30MAF_26560356_Chip-Seq_TH2_Human2.01726916
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01570085
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93587410
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.88250844
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84772506
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82210424
36* SPI1_23547873_ChIP-Seq_NB4_Human1.80195597
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77667864
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77445952
39VDR_24763502_ChIP-Seq_THP-1_Human1.74094466
40E2F7_22180533_ChIP-Seq_HELA_Human1.72924317
41KDM2B_26808549_Chip-Seq_DND41_Human1.70085087
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.65125208
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63554528
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.62597582
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60752324
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55422693
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55205553
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54275806
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50047860
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49333134
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47832317
52SPI1_23127762_ChIP-Seq_K562_Human1.42411397
53GATA3_26560356_Chip-Seq_TH2_Human1.36664832
54PU_27001747_Chip-Seq_BMDM_Mouse1.35225587
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33876392
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33476179
57CIITA_25753668_ChIP-Seq_RAJI_Human1.32376392
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31422803
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25238747
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21421983
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17371921
62* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16078208
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.15584534
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12228283
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11586574
66GATA1_22025678_ChIP-Seq_K562_Human1.10704270
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10640181
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08977059
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06873290
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05728829
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04711582
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01064030
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99854520
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99627814
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97936577
76* LXR_22292898_ChIP-Seq_THP-1_Human0.97915008
77PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96957880
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.95153960
79IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94339346
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.94142591
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93506034
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93185420
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92403259
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91551411
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91095735
86NCOR1_26117541_ChIP-Seq_K562_Human0.90853347
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89333016
88GATA2_19941826_ChIP-Seq_K562_Human0.88512952
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86708536
90GATA1_19941826_ChIP-Seq_K562_Human0.83313715
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82412397
92BCL6_27268052_Chip-Seq_Bcells_Human0.81342861
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80413136
94VDR_24787735_ChIP-Seq_THP-1_Human0.79213661
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77785689
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77677535
97GATA3_26560356_Chip-Seq_TH1_Human0.76452881
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.76059186
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75419089
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71604420
101SPI1_20517297_ChIP-Seq_HL60_Human0.71276271
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71119697
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70254163
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69796736
105TBX20_22080862_ChIP-Seq_HEART_Mouse0.69572027
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.69572027
107BCOR_27268052_Chip-Seq_Bcells_Human0.69429170
108RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68473140
109HOXB4_20404135_ChIP-ChIP_EML_Mouse0.65963971
110SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65869870
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65311562
112FOXP3_21729870_ChIP-Seq_TREG_Human0.61828095
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60046022
114RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.59471845
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.58428081
116SMRT_27268052_Chip-Seq_Bcells_Human0.57588542
117* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.57151529
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.56479382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.93782855
2MP0005671_abnormal_response_to4.46720306
3MP0001835_abnormal_antigen_presentation4.01566532
4MP0001800_abnormal_humoral_immune3.73812522
5MP0005387_immune_system_phenotype3.62110237
6MP0001790_abnormal_immune_system3.62110237
7MP0000685_abnormal_immune_system3.56100202
8MP0001873_stomach_inflammation2.99126554
9MP0005000_abnormal_immune_tolerance2.97110387
10MP0002420_abnormal_adaptive_immunity2.94546077
11MP0002723_abnormal_immune_serum2.92930866
12MP0002452_abnormal_antigen_presenting2.89803732
13MP0001819_abnormal_immune_cell2.88843957
14MP0002398_abnormal_bone_marrow2.80825002
15MP0002166_altered_tumor_susceptibility2.66828024
16MP0000716_abnormal_immune_system2.50068508
17MP0009785_altered_susceptibility_to2.46283324
18MP0005025_abnormal_response_to2.38244000
19MP0003300_gastrointestinal_ulcer2.34804153
20MP0002396_abnormal_hematopoietic_system2.34548808
21MP0009333_abnormal_splenocyte_physiolog2.34165866
22MP0000689_abnormal_spleen_morphology2.30573834
23MP0000703_abnormal_thymus_morphology2.29721422
24MP0002405_respiratory_system_inflammati2.22929019
25MP0002722_abnormal_immune_system2.22627235
26MP0010155_abnormal_intestine_physiology2.17646131
27MP0002006_tumorigenesis2.17313642
28MP0006082_CNS_inflammation2.15808143
29MP0003724_increased_susceptibility_to2.13785484
30MP0003866_abnormal_defecation2.11441473
31MP0003436_decreased_susceptibility_to2.09862015
32MP0003303_peritoneal_inflammation2.03383167
33MP0002429_abnormal_blood_cell2.03208253
34MP0002148_abnormal_hypersensitivity_rea1.98521832
35MP0002419_abnormal_innate_immunity1.86713813
36MP0004947_skin_inflammation1.81220051
37MP0004808_abnormal_hematopoietic_stem1.81037177
38MP0008260_abnormal_autophagy1.75877658
39MP0001845_abnormal_inflammatory_respons1.73273193
40MP0005464_abnormal_platelet_physiology1.72370434
41MP0004510_myositis1.63315770
42MP0001853_heart_inflammation1.58053565
43MP0002933_joint_inflammation1.57373022
44MP0002009_preneoplasia1.52846990
45MP0000465_gastrointestinal_hemorrhage1.51926586
46MP0004883_abnormal_blood_vessel1.44545258
47MP0003690_abnormal_glial_cell1.38684544
48MP0003172_abnormal_lysosome_physiology1.38495180
49MP0005310_abnormal_salivary_gland1.21651895
50MP0003448_altered_tumor_morphology1.21232096
51MP0002138_abnormal_hepatobiliary_system1.20741644
52MP0000858_altered_metastatic_potential1.20318062
53MP0008469_abnormal_protein_level1.15980692
54MP0005058_abnormal_lysosome_morphology1.13832877
55MP0000490_abnormal_crypts_of1.12584813
56MP0001545_abnormal_hematopoietic_system1.10593143
57MP0005397_hematopoietic_system_phenotyp1.10593143
58MP0005167_abnormal_blood-brain_barrier1.10303713
59MP0003075_altered_response_to1.09473435
60MP0005164_abnormal_response_to1.08673471
61MP0008961_abnormal_basal_metabolism1.06285503
62MP0004130_abnormal_muscle_cell1.01122517
63MP0009278_abnormal_bone_marrow1.00992439
64MP0004484_altered_response_of0.98300021
65MP0008004_abnormal_stomach_pH0.96230986
66MP0004381_abnormal_hair_follicle0.96153928
67MP0003045_fibrosis0.95277824
68MP0005075_abnormal_melanosome_morpholog0.93184527
69MP0001879_abnormal_lymphatic_vessel0.92928526
70MP0001533_abnormal_skeleton_physiology0.92225231
71MP0002019_abnormal_tumor_incidence0.90435501
72MP0000604_amyloidosis0.89755592
73MP0010352_gastrointestinal_tract_polyps0.87564972
74MP0001851_eye_inflammation0.87476689
75MP0003828_pulmonary_edema0.84848969
76MP0002132_abnormal_respiratory_system0.82184029
77MP0008057_abnormal_DNA_replication0.81626541
78MP0009764_decreased_sensitivity_to0.80489814
79MP0002136_abnormal_kidney_physiology0.79575976
80MP0002332_abnormal_exercise_endurance0.79454870
81MP0002998_abnormal_bone_remodeling0.78477149
82MP0003091_abnormal_cell_migration0.78381428
83MP0005390_skeleton_phenotype0.73621327
84MP0009763_increased_sensitivity_to0.73331485
85MP0001958_emphysema0.70616539
86MP0005174_abnormal_tail_pigmentation0.69348469
87MP0003221_abnormal_cardiomyocyte_apopto0.68398796
88MP0009115_abnormal_fat_cell0.65400747
89MP0005388_respiratory_system_phenotype0.64558056
90MP0002133_abnormal_respiratory_system0.64558056
91MP0000249_abnormal_blood_vessel0.64018467
92MP0009840_abnormal_foam_cell0.63537615
93MP0003787_abnormal_imprinting0.63455930
94MP0001663_abnormal_digestive_system0.63448671
95MP0000609_abnormal_liver_physiology0.62834852
96MP0010368_abnormal_lymphatic_system0.60834160
97MP0005023_abnormal_wound_healing0.59856856
98MP0009765_abnormal_xenobiotic_induced0.57536987
99MP0005670_abnormal_white_adipose0.55987413
100MP0005165_increased_susceptibility_to0.53253449
101MP0003453_abnormal_keratinocyte_physiol0.53071710
102MP0003943_abnormal_hepatobiliary_system0.52035955
103MP0006054_spinal_hemorrhage0.51860294
104MP0003183_abnormal_peptide_metabolism0.50533028
105MP0003566_abnormal_cell_adhesion0.50396337
106MP0002928_abnormal_bile_duct0.49243684
107MP0000477_abnormal_intestine_morphology0.48331587
108MP0005451_abnormal_body_composition0.47969103
109MP0003279_aneurysm0.47526757
110MP0008874_decreased_physiological_sensi0.46332237
111MP0001191_abnormal_skin_condition0.44981739
112MP0000767_abnormal_smooth_muscle0.43911930
113MP0003795_abnormal_bone_structure0.43810657
114MP0000343_altered_response_to0.43077994
115MP0002277_abnormal_respiratory_mucosa0.42229962
116MP0002168_other_aberrant_phenotype0.41883913
117MP0003191_abnormal_cellular_cholesterol0.41833887
118MP0000015_abnormal_ear_pigmentation0.40379471
119MP0005166_decreased_susceptibility_to0.39350722
120MP0004185_abnormal_adipocyte_glucose0.39187357
121MP0003868_abnormal_feces_composition0.38650001

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.25330276
2Abnormality of T cell number (HP:0011839)6.02774825
3Recurrent bronchitis (HP:0002837)5.27167394
4Abnormality of macrophages (HP:0004311)4.97587862
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.89077451
6Agammaglobulinemia (HP:0004432)4.80542557
7IgM deficiency (HP:0002850)4.80128522
8Abnormality of T cells (HP:0002843)4.73673082
9Recurrent viral infections (HP:0004429)4.72627423
10Panhypogammaglobulinemia (HP:0003139)4.64656796
11Chronic otitis media (HP:0000389)4.56666418
12Recurrent gram-negative bacterial infections (HP:0005420)4.54633830
13Abnormality of the fingertips (HP:0001211)4.35511198
14Recurrent fungal infections (HP:0002841)4.15955153
15Nasal polyposis (HP:0100582)4.11987510
16Inflammation of the large intestine (HP:0002037)4.01394029
17Myositis (HP:0100614)3.97061684
18Elevated erythrocyte sedimentation rate (HP:0003565)3.93546819
19Recurrent cutaneous fungal infections (HP:0011370)3.92529664
20Chronic mucocutaneous candidiasis (HP:0002728)3.92529664
21Abnormality of the nasal mucosa (HP:0000433)3.86118524
22Gastrointestinal inflammation (HP:0004386)3.82052124
23Meningitis (HP:0001287)3.81906452
24Lymphopenia (HP:0001888)3.77697537
25Gastrointestinal stroma tumor (HP:0100723)3.73135000
26Colitis (HP:0002583)3.71573981
27Autoimmune thrombocytopenia (HP:0001973)3.70190730
28Pustule (HP:0200039)3.68753381
29Spontaneous hematomas (HP:0007420)3.65248058
30Recurrent sinusitis (HP:0011108)3.61937504
31Vasculitis (HP:0002633)3.59478041
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.58419915
33Severe combined immunodeficiency (HP:0004430)3.51874138
34Encephalitis (HP:0002383)3.48031933
35Chronic diarrhea (HP:0002028)3.46486594
36IgG deficiency (HP:0004315)3.42262763
37Combined immunodeficiency (HP:0005387)3.41971386
38Verrucae (HP:0200043)3.39952462
39Papilloma (HP:0012740)3.39952462
40Abnormality of T cell physiology (HP:0011840)3.39206113
41Stomatitis (HP:0010280)3.39018621
42Gingivitis (HP:0000230)3.37555760
43Retrobulbar optic neuritis (HP:0100654)3.35898308
44Optic neuritis (HP:0100653)3.35898308
45Chronic sinusitis (HP:0011109)3.15087222
46Autoimmune hemolytic anemia (HP:0001890)3.15051139
47IgA deficiency (HP:0002720)3.07937151
48Prolonged bleeding time (HP:0003010)3.01892708
49Eczematoid dermatitis (HP:0000976)3.00569181
50B lymphocytopenia (HP:0010976)3.00099756
51Abnormality of B cell number (HP:0010975)3.00099756
52Thyroiditis (HP:0100646)2.99958768
53Joint swelling (HP:0001386)2.94506629
54Bronchitis (HP:0012387)2.92999318
55Pulmonary infiltrates (HP:0002113)2.92553492
56Orchitis (HP:0100796)2.89226722
57Abnormality of eosinophils (HP:0001879)2.87662917
58Increased IgE level (HP:0003212)2.85522849
59Eosinophilia (HP:0001880)2.85209397
60Emphysema (HP:0002097)2.83676341
61Urticaria (HP:0001025)2.80728621
62Hemoptysis (HP:0002105)2.80088365
63Cellulitis (HP:0100658)2.71241377
64Lymphoma (HP:0002665)2.69820177
65Mediastinal lymphadenopathy (HP:0100721)2.65430666
66Recurrent abscess formation (HP:0002722)2.58874745
67Arterial thrombosis (HP:0004420)2.57623876
68Granulocytopenia (HP:0001913)2.54403533
69Amyloidosis (HP:0011034)2.53940991
70Leukocytosis (HP:0001974)2.52441743
71Epistaxis (HP:0000421)2.51641192
72Recurrent skin infections (HP:0001581)2.50679886
73Keratoconjunctivitis sicca (HP:0001097)2.48556155
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48549211
75Abnormal platelet volume (HP:0011876)2.48184696
76Peritonitis (HP:0002586)2.47423872
77Pulmonary embolism (HP:0002204)2.47241818
78Systemic lupus erythematosus (HP:0002725)2.43589656
79Thrombocytosis (HP:0001894)2.43475655
80Basal cell carcinoma (HP:0002671)2.42885324
81Recurrent otitis media (HP:0000403)2.41992120
82Chest pain (HP:0100749)2.39721433
83Osteomyelitis (HP:0002754)2.36531800
84Polycythemia (HP:0001901)2.36448662
85Chronic obstructive pulmonary disease (HP:0006510)2.30502714
86Obstructive lung disease (HP:0006536)2.30502714
87Episodic fever (HP:0001954)2.29661989
88Purpura (HP:0000979)2.29388090
89Anorexia (HP:0002039)2.28737121
90Hypochromic anemia (HP:0001931)2.27722110
91Keratoconjunctivitis (HP:0001096)2.26993939
92Gangrene (HP:0100758)2.22544527
93Restrictive lung disease (HP:0002091)2.21845774
94Abnormality of the pleura (HP:0002103)2.20955791
95Hypochromic microcytic anemia (HP:0004840)2.20196050
96Ureteral stenosis (HP:0000071)2.20122570
97Gingival bleeding (HP:0000225)2.17003922
98Petechiae (HP:0000967)2.14804871
99Abnormality of the endocardium (HP:0004306)2.11691031
100Abnormality of glycolipid metabolism (HP:0010969)2.08716819
101Abnormality of liposaccharide metabolism (HP:0010968)2.08716819
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.08716819
103Hemiplegia (HP:0002301)2.08145057
104Gastrointestinal infarctions (HP:0005244)2.07949650
105Recurrent bacterial skin infections (HP:0005406)2.06975818
106Hepatitis (HP:0012115)2.05494451
107Vertigo (HP:0002321)2.05391636
108Glomerulopathy (HP:0100820)2.03791500
109Abnormality of the peritoneum (HP:0002585)2.02587580
110Ureteral obstruction (HP:0006000)2.01719087
111Viral hepatitis (HP:0006562)2.01141468
112Sepsis (HP:0100806)2.00807019
113Increased IgM level (HP:0003496)1.99216909
114Increased mean platelet volume (HP:0011877)1.96190017
115Loss of speech (HP:0002371)1.95568799
116Skin ulcer (HP:0200042)1.94217097
117Aortic aneurysm (HP:0004942)1.93781561
118Increased density of long bones (HP:0006392)1.93189097
119Acne (HP:0001061)1.93059827
120Abnormality of the prostate (HP:0008775)1.92972686
121Leukopenia (HP:0001882)1.91238726
122Hypergammaglobulinemia (HP:0010702)1.91221373
123Arthralgia (HP:0002829)1.91034982
124Hematochezia (HP:0002573)1.90979533
125Slow saccadic eye movements (HP:0000514)1.89759266
126Thrombophlebitis (HP:0004418)1.89023644
127Difficulty running (HP:0009046)1.86549238
128Polyneuropathy (HP:0001271)1.86224983
129Periodontitis (HP:0000704)1.85941345
130Hypoplasia of the thymus (HP:0000778)1.85466710
131Microcytic anemia (HP:0001935)1.82034777
132Bronchiectasis (HP:0002110)1.80748816
133Interstitial pulmonary disease (HP:0006530)1.79113197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.03803544
2TXK5.24867535
3RIPK44.04684901
4JAK33.12815249
5ITK2.91572279
6FGFR42.80487021
7STK102.68712475
8TYK22.53791905
9JAK12.49306842
10IKBKE2.47537557
11GRK62.42638986
12PRPF4B2.42206876
13MAP3K142.38693726
14ZAP702.27848943
15FGFR32.12677428
16MAP3K132.11130734
17TEC1.84972945
18NLK1.82438674
19TGFBR21.75748909
20LCK1.71848623
21BTK1.67112731
22MARK31.66587259
23FGR1.61940198
24CSK1.61801157
25SYK1.60310668
26MAP3K101.53036209
27EEF2K1.48460472
28SIK21.44245848
29MAP3K31.39073390
30TBK11.37268093
31HCK1.33967166
32PRKCQ1.33459454
33KIT1.30129903
34LRRK21.27338187
35PRKCH1.24581079
36IKBKB1.22381259
37KDR1.21156014
38IRAK41.16318512
39PIM11.15494697
40TAOK11.15204455
41MAP3K111.12967024
42MST41.11497827
43BLK1.10562441
44CDK121.09563883
45MAP3K11.09232208
46CSF1R1.08302299
47YES11.05966034
48SIK31.04795987
49IRAK31.00642516
50MAP3K70.96730027
51KSR20.95505940
52FES0.93661222
53CAMKK20.93055348
54JAK20.91607005
55CHUK0.89136596
56PKN20.88273010
57TNK20.87180506
58LYN0.86722532
59TTN0.85174040
60MAP3K60.84735481
61RPS6KA40.83104926
62CDC42BPA0.82042303
63TIE10.79575924
64PRKD20.78264075
65CLK10.76408216
66PDPK10.76289903
67MAPK70.75081113
68EPHB10.75011686
69EPHA30.71385695
70STK240.69095851
71RIPK10.68965643
72BMPR20.68620919
73TGFBR10.68275636
74BRD40.68010151
75PIK3CG0.67922560
76MATK0.66146685
77MAPK120.64896801
78MAP2K30.64663260
79CDK40.61271428
80HIPK20.60461329
81PTK2B0.59882226
82PDK10.58255097
83NUAK10.57359126
84FGFR20.57036240
85CAMKK10.55611037
86MAP3K20.55034076
87PDGFRB0.54351224
88FLT30.53258697
89TRPM70.51588725
90SIK10.50527539
91MARK20.50488935
92MELK0.48684883
93SGK30.48402482
94DYRK1B0.47056148
95GRK10.46018865
96DMPK0.45942580
97RET0.45473051
98CDK90.45176804
99TAOK30.44342271
100ERN10.42870042
101TAOK20.42776850
102NME20.42677659
103PTK60.41016758
104MAP3K50.39991627
105INSR0.39983441
106TYRO30.39934542
107STK40.38889724
108RPS6KL10.37220915
109RPS6KC10.37220915
110IGF1R0.36981824
111ALK0.36655234
112SMG10.36377715
113FER0.35110958
114CDK60.34531804
115STK380.33594236
116MAPK110.32945476
117MAPK40.32488414
118IRAK10.32376637
119RAF10.32049110
120ABL10.31384478
121PRKAA20.31212334
122CAMK1G0.30097481
123TRIB30.29429829
124FYN0.28809108
125SGK20.26900364
126STK110.26210649
127MAPK30.25248449
128PRKD10.24377819
129GRK70.22552548
130NEK90.22131940
131EGFR0.19670761

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.52540295
2T cell receptor signaling pathway_Homo sapiens_hsa046603.37132243
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.07535277
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.88032623
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.87946443
6B cell receptor signaling pathway_Homo sapiens_hsa046622.85453241
7Graft-versus-host disease_Homo sapiens_hsa053322.81788115
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.80046637
9Allograft rejection_Homo sapiens_hsa053302.65253014
10Measles_Homo sapiens_hsa051622.60747420
11Hematopoietic cell lineage_Homo sapiens_hsa046402.48889585
12Antigen processing and presentation_Homo sapiens_hsa046122.32001348
13Autoimmune thyroid disease_Homo sapiens_hsa053202.19694614
14Osteoclast differentiation_Homo sapiens_hsa043802.07418731
15Leishmaniasis_Homo sapiens_hsa051401.94578735
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.89124412
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83149511
18Viral myocarditis_Homo sapiens_hsa054161.79371592
19Herpes simplex infection_Homo sapiens_hsa051681.61459252
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.55745491
21Chemokine signaling pathway_Homo sapiens_hsa040621.50895253
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41942689
23Toxoplasmosis_Homo sapiens_hsa051451.40772503
24Other glycan degradation_Homo sapiens_hsa005111.39281258
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38627777
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34475117
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33173360
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32656686
29Acute myeloid leukemia_Homo sapiens_hsa052211.32534444
30Influenza A_Homo sapiens_hsa051641.27373751
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27223015
32Hepatitis B_Homo sapiens_hsa051611.25715815
33Platelet activation_Homo sapiens_hsa046111.24971303
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24629311
35Phagosome_Homo sapiens_hsa041451.23612309
36TNF signaling pathway_Homo sapiens_hsa046681.22635673
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12231003
38Type I diabetes mellitus_Homo sapiens_hsa049401.06962622
39Apoptosis_Homo sapiens_hsa042101.06641194
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05761359
41Pancreatic cancer_Homo sapiens_hsa052121.04670451
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04292655
43Malaria_Homo sapiens_hsa051440.99574423
44HTLV-I infection_Homo sapiens_hsa051660.99056007
45Hepatitis C_Homo sapiens_hsa051600.96498109
46Chronic myeloid leukemia_Homo sapiens_hsa052200.96455145
47Shigellosis_Homo sapiens_hsa051310.93284326
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87671865
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84939688
50Epstein-Barr virus infection_Homo sapiens_hsa051690.84812408
51Staphylococcus aureus infection_Homo sapiens_hsa051500.83500378
52Prolactin signaling pathway_Homo sapiens_hsa049170.80683890
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.78237481
54Tuberculosis_Homo sapiens_hsa051520.78086931
55Colorectal cancer_Homo sapiens_hsa052100.76908268
56Lysosome_Homo sapiens_hsa041420.73204386
57Small cell lung cancer_Homo sapiens_hsa052220.70312031
58Asthma_Homo sapiens_hsa053100.69336656
59Notch signaling pathway_Homo sapiens_hsa043300.65700927
60VEGF signaling pathway_Homo sapiens_hsa043700.65644722
61Non-small cell lung cancer_Homo sapiens_hsa052230.65437487
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65174946
63Lysine degradation_Homo sapiens_hsa003100.64817593
64Amoebiasis_Homo sapiens_hsa051460.64718404
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64603897
66FoxO signaling pathway_Homo sapiens_hsa040680.63946882
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61365063
68Insulin resistance_Homo sapiens_hsa049310.60924227
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.60037168
70GnRH signaling pathway_Homo sapiens_hsa049120.59683820
71Viral carcinogenesis_Homo sapiens_hsa052030.59544154
72Non-homologous end-joining_Homo sapiens_hsa034500.58700777
73Inositol phosphate metabolism_Homo sapiens_hsa005620.58490694
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56601969
75Legionellosis_Homo sapiens_hsa051340.56286578
76Complement and coagulation cascades_Homo sapiens_hsa046100.55401194
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55019917
78Pertussis_Homo sapiens_hsa051330.53923139
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52667571
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50912525
81African trypanosomiasis_Homo sapiens_hsa051430.49403927
82ABC transporters_Homo sapiens_hsa020100.47506961
83Salmonella infection_Homo sapiens_hsa051320.47485065
84Rap1 signaling pathway_Homo sapiens_hsa040150.47482240
85MAPK signaling pathway_Homo sapiens_hsa040100.46837889
86Prostate cancer_Homo sapiens_hsa052150.45802972
87Renal cell carcinoma_Homo sapiens_hsa052110.43705759
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42345996
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39467019
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.39399293
91mTOR signaling pathway_Homo sapiens_hsa041500.38816472
92Dorso-ventral axis formation_Homo sapiens_hsa043200.38051249
93Rheumatoid arthritis_Homo sapiens_hsa053230.37425913
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.37210333
95HIF-1 signaling pathway_Homo sapiens_hsa040660.37171619
96Ribosome_Homo sapiens_hsa030100.36384982
97Type II diabetes mellitus_Homo sapiens_hsa049300.35553385
98Choline metabolism in cancer_Homo sapiens_hsa052310.35429856
99Long-term potentiation_Homo sapiens_hsa047200.34549198
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.34466385
101Endocytosis_Homo sapiens_hsa041440.34380515
102Pathways in cancer_Homo sapiens_hsa052000.33918828
103p53 signaling pathway_Homo sapiens_hsa041150.33856043
104Endometrial cancer_Homo sapiens_hsa052130.33416052
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.33412309
106Adherens junction_Homo sapiens_hsa045200.32023302
107Focal adhesion_Homo sapiens_hsa045100.31826809
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.30489074
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30099807
110Proteoglycans in cancer_Homo sapiens_hsa052050.28000465
111MicroRNAs in cancer_Homo sapiens_hsa052060.25123745
112Caffeine metabolism_Homo sapiens_hsa002320.24793816
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23371944
114Ras signaling pathway_Homo sapiens_hsa040140.22226930
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20744774

Most similar genes based on co-expression Upload to Enrichr

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