ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	7.38474392
2	intestinal cholesterol absorption (GO:0030299)	6.58758395
3	intestinal absorption (GO:0050892)	6.33978101
4	high-density lipoprotein particle remodeling (GO:0034375)	6.09334423
5	regulation of triglyceride catabolic process (GO:0010896)	5.92842062
6	L-phenylalanine catabolic process (GO:0006559)	5.92308635
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.92308635
8	reverse cholesterol transport (GO:0043691)	5.90629795
9	phospholipid efflux (GO:0033700)	5.81850911
10	L-phenylalanine metabolic process (GO:0006558)	5.79100763
11	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.79100763
12	regulation of cholesterol esterification (GO:0010872)	5.76234460
13	urea metabolic process (GO:0019627)	5.55356688
14	urea cycle (GO:0000050)	5.55356688
15	aromatic amino acid family catabolic process (GO:0009074)	5.31604996
16	protein-lipid complex remodeling (GO:0034368)	5.31509880
17	macromolecular complex remodeling (GO:0034367)	5.31509880
18	plasma lipoprotein particle remodeling (GO:0034369)	5.31509880
19	plasma lipoprotein particle assembly (GO:0034377)	5.20880270
20	negative regulation of cholesterol transport (GO:0032375)	5.19120014
21	negative regulation of sterol transport (GO:0032372)	5.19120014
22	cholesterol efflux (GO:0033344)	5.18378165
23	positive regulation of triglyceride lipase activity (GO:0061365)	5.10706441
24	positive regulation of lipoprotein lipase activity (GO:0051006)	5.10706441
25	nitrogen cycle metabolic process (GO:0071941)	5.03560508
26	homocysteine metabolic process (GO:0050667)	4.99760985
27	drug catabolic process (GO:0042737)	4.88161752
28	alpha-linolenic acid metabolic process (GO:0036109)	4.87008490
29	cysteine metabolic process (GO:0006534)	4.84828171
30	kynurenine metabolic process (GO:0070189)	4.81065366
31	protein-lipid complex assembly (GO:0065005)	4.78938669
32	tryptophan catabolic process (GO:0006569)	4.77675366
33	indole-containing compound catabolic process (GO:0042436)	4.77675366
34	indolalkylamine catabolic process (GO:0046218)	4.77675366
35	very-low-density lipoprotein particle assembly (GO:0034379)	4.73569925
36	acylglycerol homeostasis (GO:0055090)	4.72496987
37	triglyceride homeostasis (GO:0070328)	4.72496987
38	bile acid biosynthetic process (GO:0006699)	4.58190012
39	glyoxylate metabolic process (GO:0046487)	4.57774417
40	flavonoid metabolic process (GO:0009812)	4.55823170
41	lipoprotein metabolic process (GO:0042157)	4.55051984
42	negative regulation of fibrinolysis (GO:0051918)	4.52569924
43	cholesterol homeostasis (GO:0042632)	4.51057222
44	tryptophan metabolic process (GO:0006568)	4.46662930
45	sterol homeostasis (GO:0055092)	4.44907505
46	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.35073505
47	cellular glucuronidation (GO:0052695)	4.34093288
48	plasma lipoprotein particle organization (GO:0071827)	4.34035472
49	regulation of protein activation cascade (GO:2000257)	4.33029650
50	sulfur amino acid catabolic process (GO:0000098)	4.32092036
51	regulation of fibrinolysis (GO:0051917)	4.28574302
52	plasma lipoprotein particle clearance (GO:0034381)	4.27359878
53	phospholipid homeostasis (GO:0055091)	4.23306277
54	regulation of bile acid biosynthetic process (GO:0070857)	4.23067839
55	bile acid and bile salt transport (GO:0015721)	4.21652588
56	bile acid metabolic process (GO:0008206)	4.16113582
57	protein-lipid complex subunit organization (GO:0071825)	4.15285175
58	complement activation, alternative pathway (GO:0006957)	4.13505742
59	amino-acid betaine metabolic process (GO:0006577)	4.10414622
60	positive regulation of lipid catabolic process (GO:0050996)	4.09866081
61	protein carboxylation (GO:0018214)	4.09862287
62	peptidyl-glutamic acid carboxylation (GO:0017187)	4.09862287
63	regulation of cholesterol homeostasis (GO:2000188)	4.08338356
64	regulation of complement activation (GO:0030449)	4.01115780
65	lysine metabolic process (GO:0006553)	3.96647436
66	lysine catabolic process (GO:0006554)	3.96647436
67	angiotensin maturation (GO:0002003)	3.95993346
68	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.93300428
69	glucuronate metabolic process (GO:0019585)	3.93215250
70	uronic acid metabolic process (GO:0006063)	3.93215250
71	cholesterol transport (GO:0030301)	3.90713414
72	sterol transport (GO:0015918)	3.90713414
73	aromatic amino acid family metabolic process (GO:0009072)	3.84422726
74	serine family amino acid catabolic process (GO:0009071)	3.83980726
75	glutamate metabolic process (GO:0006536)	3.81447569
76	positive regulation of triglyceride metabolic process (GO:0090208)	3.75017186
77	serine family amino acid biosynthetic process (GO:0009070)	3.69153689
78	glutamine family amino acid biosynthetic process (GO:0009084)	3.68024224
79	cellular ketone body metabolic process (GO:0046950)	3.62094843
80	response to nitrosative stress (GO:0051409)	3.62047270
81	alpha-amino acid catabolic process (GO:1901606)	3.60049229
82	arginine metabolic process (GO:0006525)	3.59606613
83	tyrosine metabolic process (GO:0006570)	3.53154482
84	lipid homeostasis (GO:0055088)	3.52404822
85	ethanol oxidation (GO:0006069)	3.50731663
86	serine family amino acid metabolic process (GO:0009069)	3.50642110
87	cellular modified amino acid catabolic process (GO:0042219)	3.47066571
88	low-density lipoprotein particle remodeling (GO:0034374)	3.46917184
89	glycine metabolic process (GO:0006544)	3.46257886
90	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.43418028
91	negative regulation of lipase activity (GO:0060192)	3.39121782
92	dicarboxylic acid biosynthetic process (GO:0043650)	3.38784544
93	drug metabolic process (GO:0017144)	3.38074201
94	coenzyme catabolic process (GO:0009109)	3.36525634
95	drug transmembrane transport (GO:0006855)	3.35186151
96	heme transport (GO:0015886)	3.35171665
97	benzene-containing compound metabolic process (GO:0042537)	3.34818348
98	cellular amino acid catabolic process (GO:0009063)	3.34062143
99	exogenous drug catabolic process (GO:0042738)	3.33434632
100	indolalkylamine metabolic process (GO:0006586)	3.32888546

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.25852910
2	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.57857204
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.12603383
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.94849507
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.30987294
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.23471895
7	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.21921375
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.73388044
9	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.51451078
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.13590790
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.77817866
12	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.24876299
13	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.18122635
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.4670413
15	GATA4_25053715_ChIP-Seq_YYC3_Human	1.83542465
16	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.78914252
17	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.76298234
18	CLOCK_20551151_ChIP-Seq_293T_Human	1.74840865
19	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.67948767
20	HTT_18923047_ChIP-ChIP_STHdh_Human	1.65862980
21	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.64244022
22	GATA1_22025678_ChIP-Seq_K562_Human	1.59173046
23	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52611442
24	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.50527309
25	GATA6_25053715_ChIP-Seq_YYC3_Human	1.36024355
26	SOX2_20726797_ChIP-Seq_SW620_Human	1.33858017
27	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.22191930
28	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.14598640
29	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.12931591
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.12083706
31	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.09586593
32	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.09191837
33	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.00342304
34	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.97592926
35	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.97391022
36	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.97178592
37	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.94634342
38	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.94528232
39	ZNF263_19887448_ChIP-Seq_K562_Human	0.94238999
40	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.93715603
41	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.93027737
42	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.91952706
43	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.91057781
44	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.88893075
45	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.88723834
46	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.88489334
47	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.84479429
48	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.83037652
49	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.80641961
50	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.79875455
51	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.79096775
52	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.78692181
53	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.78246049
54	GATA2_19941826_ChIP-Seq_K562_Human	0.77620628
55	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.77520265
56	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.75719721
57	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.73018123
58	STAT1_17558387_ChIP-Seq_HELA_Human	0.71264114
59	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.70638392
60	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.70131660
61	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.69912726
62	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.69054233
63	AR_21909140_ChIP-Seq_LNCAP_Human	0.68941263
64	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.67368497
65	EGR1_19032775_ChIP-ChIP_M12_Human	0.66868994
66	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.66716777
67	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.65688325
68	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.65211709
69	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.65211709
70	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.64240609
71	RACK7_27058665_Chip-Seq_MCF-7_Human	0.63445150
72	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.63150687
73	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.62246481
74	ATF3_27146783_Chip-Seq_COLON_Human	0.62088146
75	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.60723437
76	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.60320020
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.60250886
78	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.59043957
79	CEBPB_22108803_ChIP-Seq_LS180_Human	0.58932833
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.58330788
81	MYC_19915707_ChIP-ChIP_AK7_Human	0.57894169
82	CDX2_22108803_ChIP-Seq_LS180_Human	0.57762749
83	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.57535801
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.57138355
85	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.57084674
86	AR_20517297_ChIP-Seq_VCAP_Human	0.56984497
87	LXR_22292898_ChIP-Seq_THP-1_Human	0.56791803
88	TP63_23658742_ChIP-Seq_EP156T_Human	0.55837749
89	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.55730648
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.55718194
91	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.54899371
92	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.54065730
93	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.53877845
94	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.53318498
95	CBP_21632823_ChIP-Seq_H3396_Human	0.52071748
96	GATA1_19941826_ChIP-Seq_K562_Human	0.51750605
97	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.51497927
98	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.51330914
99	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.51287934
100	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.51276055

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	9.00324343
2	MP0002139_abnormal_hepatobiliary_system	7.54070381
3	MP0005085_abnormal_gallbladder_physiolo	5.92634646
4	MP0005365_abnormal_bile_salt	5.06280041
5	MP0008875_abnormal_xenobiotic_pharmacok	4.49641884
6	MP0003252_abnormal_bile_duct	4.39819152
7	MP0001666_abnormal_nutrient_absorption	4.16054777
8	MP0009840_abnormal_foam_cell	3.96293681
9	MP0010329_abnormal_lipoprotein_level	3.71626315
10	MP0003806_abnormal_nucleotide_metabolis	3.31695616
11	MP0005332_abnormal_amino_acid	2.49683621
12	MP0005083_abnormal_biliary_tract	2.36726537
13	MP0004019_abnormal_vitamin_homeostasis	2.34370062
14	MP0003191_abnormal_cellular_cholesterol	2.09091967
15	MP0009697_abnormal_copulation	2.06299017
16	MP0000609_abnormal_liver_physiology	1.94493574
17	MP0003195_calcinosis	1.93481870
18	MP0002118_abnormal_lipid_homeostasis	1.89496002
19	MP0002138_abnormal_hepatobiliary_system	1.88746939
20	MP0010234_abnormal_vibrissa_follicle	1.72696519
21	MP0005084_abnormal_gallbladder_morpholo	1.60680583
22	MP0004264_abnormal_extraembryonic_tissu	1.54560165
23	MP0005319_abnormal_enzyme/_coenzyme	1.53295004
24	MP0003705_abnormal_hypodermis_morpholog	1.47499528
25	MP0003868_abnormal_feces_composition	1.46644321
26	MP0001764_abnormal_homeostasis	1.36616983
27	MP0009643_abnormal_urine_homeostasis	1.28151351
28	MP0005584_abnormal_enzyme/coenzyme_acti	1.24938153
29	MP0005451_abnormal_body_composition	1.19856080
30	MP0002876_abnormal_thyroid_physiology	1.10794660
31	MP0003183_abnormal_peptide_metabolism	1.06789312
32	MP0002254_reproductive_system_inflammat	1.01892964
33	MP0000598_abnormal_liver_morphology	1.00756266
34	MP0003011_delayed_dark_adaptation	0.97252397
35	MP0003656_abnormal_erythrocyte_physiolo	0.95907328
36	MP0000462_abnormal_digestive_system	0.92800517
37	MP0002822_catalepsy	0.91697851
38	MP0000604_amyloidosis	0.91518755
39	MP0005448_abnormal_energy_balance	0.86109418
40	MP0000537_abnormal_urethra_morphology	0.86078569
41	MP0009764_decreased_sensitivity_to	0.85633428
42	MP0005636_abnormal_mineral_homeostasis	0.82506904
43	MP0009053_abnormal_anal_canal	0.82420391
44	MP0009642_abnormal_blood_homeostasis	0.79927004
45	MP0003186_abnormal_redox_activity	0.78619244
46	MP0005220_abnormal_exocrine_pancreas	0.77090833
47	MP0005408_hypopigmentation	0.73578952
48	MP0008469_abnormal_protein_level	0.73343145
49	MP0005376_homeostasis/metabolism_phenot	0.72441446
50	MP0000538_abnormal_urinary_bladder	0.71676557
51	MP0009763_increased_sensitivity_to	0.71064270
52	MP0002796_impaired_skin_barrier	0.69970526
53	MP0005266_abnormal_metabolism	0.69584865
54	MP0003718_maternal_effect	0.68079954
55	MP0005167_abnormal_blood-brain_barrier	0.67052545
56	MP0004147_increased_porphyrin_level	0.66088324
57	MP0003300_gastrointestinal_ulcer	0.65746232
58	MP0009384_cardiac_valve_regurgitation	0.65171512
59	MP0002078_abnormal_glucose_homeostasis	0.64506379
60	MP0005647_abnormal_sex_gland	0.61516610
61	MP0002136_abnormal_kidney_physiology	0.60506114
62	MP0009765_abnormal_xenobiotic_induced	0.60113286
63	MP0000477_abnormal_intestine_morphology	0.57551493
64	MP0001663_abnormal_digestive_system	0.57502279
65	MP0008872_abnormal_physiological_respon	0.57381057
66	MP0006036_abnormal_mitochondrial_physio	0.56856148
67	MP0004043_abnormal_pH_regulation	0.56331093
68	MP0005334_abnormal_fat_pad	0.56262634
69	MP0005248_abnormal_Harderian_gland	0.56092097
70	MP0010155_abnormal_intestine_physiology	0.55298175
71	MP0005166_decreased_susceptibility_to	0.54917500
72	MP0005381_digestive/alimentary_phenotyp	0.51189182
73	MP0002928_abnormal_bile_duct	0.50829798
74	MP0003638_abnormal_response/metabolism_	0.50527039
75	MP0002971_abnormal_brown_adipose	0.49418566
76	MP0001756_abnormal_urination	0.48865344
77	MP0003453_abnormal_keratinocyte_physiol	0.48843994
78	MP0009379_abnormal_foot_pigmentation	0.46727891
79	MP0005395_other_phenotype	0.46418036
80	MP0010368_abnormal_lymphatic_system	0.45049834
81	MP0005464_abnormal_platelet_physiology	0.43591418
82	MP0004947_skin_inflammation	0.43203803
83	MP0005535_abnormal_body_temperature	0.43118992
84	MP0003329_amyloid_beta_deposits	0.42022985
85	MP0002089_abnormal_postnatal_growth/wei	0.41554134
86	MP0008873_increased_physiological_sensi	0.40884283
87	MP0010678_abnormal_skin_adnexa	0.40576674
88	MP0003866_abnormal_defecation	0.40281276
89	MP0005501_abnormal_skin_physiology	0.39416875
90	MP0000427_abnormal_hair_cycle	0.39305317
91	MP0001881_abnormal_mammary_gland	0.38253319
92	MP0001664_abnormal_digestion	0.36895393
93	MP0009115_abnormal_fat_cell	0.36407053
94	MP0010352_gastrointestinal_tract_polyps	0.36389714
95	MP0000249_abnormal_blood_vessel	0.35374726
96	MP0003953_abnormal_hormone_level	0.33928596
97	MP0002060_abnormal_skin_morphology	0.32547618
98	MP0006054_spinal_hemorrhage	0.32477029
99	MP0005666_abnormal_adipose_tissue	0.32142252
100	MP0005165_increased_susceptibility_to	0.31428586

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	7.65858776
2	Intrahepatic cholestasis (HP:0001406)	6.82746789
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.29884010
4	Xanthomatosis (HP:0000991)	6.09688230
5	Deep venous thrombosis (HP:0002625)	6.05709085
6	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.03685982
7	Abnormality of glutamine family amino acid metabolism (HP:0010902)	5.71914106
8	Hypolipoproteinemia (HP:0010981)	5.27637897
9	Prolonged partial thromboplastin time (HP:0003645)	5.09305926
10	Acanthocytosis (HP:0001927)	4.75333212
11	Conjugated hyperbilirubinemia (HP:0002908)	4.74370441
12	Fat malabsorption (HP:0002630)	4.71335741
13	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.61414440
14	Epidermoid cyst (HP:0200040)	4.26801318
15	Hyperammonemia (HP:0001987)	4.20331566
16	Hyperlipoproteinemia (HP:0010980)	4.18979908
17	Complement deficiency (HP:0004431)	4.18708857
18	Hypercholesterolemia (HP:0003124)	4.15627823
19	Hyperglycinuria (HP:0003108)	4.10622070
20	Abnormality of the common coagulation pathway (HP:0010990)	3.93173584
21	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.90417343
22	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.89079484
23	Abnormality of serine family amino acid metabolism (HP:0010894)	3.81030257
24	Abnormality of glycine metabolism (HP:0010895)	3.81030257
25	Hypoalphalipoproteinemia (HP:0003233)	3.74094896
26	Hypoglycemic coma (HP:0001325)	3.67644002
27	Joint hemorrhage (HP:0005261)	3.51989483
28	Ileus (HP:0002595)	3.48425399
29	Abnormality of pyrimidine metabolism (HP:0004353)	3.47837709
30	Malnutrition (HP:0004395)	3.46472632
31	Ketosis (HP:0001946)	3.44343177
32	Hyperbilirubinemia (HP:0002904)	3.33761231
33	Hyperglycinemia (HP:0002154)	3.32739408
34	Poikilocytosis (HP:0004447)	3.22135748
35	Abnormality of proline metabolism (HP:0010907)	3.19901717
36	Hydroxyprolinuria (HP:0003080)	3.19901717
37	Abnormality of complement system (HP:0005339)	3.08401185
38	Abnormality of nucleobase metabolism (HP:0010932)	3.06668671
39	Abnormality of the intrinsic pathway (HP:0010989)	2.95690408
40	Abnormality of methionine metabolism (HP:0010901)	2.94423457
41	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.91646479
42	Abnormality of purine metabolism (HP:0004352)	2.86084152
43	Ketoacidosis (HP:0001993)	2.83330834
44	Autoimmune thrombocytopenia (HP:0001973)	2.81087982
45	Hepatocellular carcinoma (HP:0001402)	2.79678991
46	Metabolic acidosis (HP:0001942)	2.78803500
47	Abnormality of fatty-acid metabolism (HP:0004359)	2.77170398
48	Cholecystitis (HP:0001082)	2.76024655
49	Abnormal gallbladder physiology (HP:0012438)	2.76024655
50	Spontaneous abortion (HP:0005268)	2.75809076
51	Steatorrhea (HP:0002570)	2.72115926
52	Systemic lupus erythematosus (HP:0002725)	2.68803587
53	Pigmentary retinal degeneration (HP:0001146)	2.68297267
54	Skin nodule (HP:0200036)	2.67656684
55	Hypoglycemic seizures (HP:0002173)	2.62525059
56	Vascular calcification (HP:0004934)	2.61124104
57	Esophageal varix (HP:0002040)	2.52226190
58	Myocardial infarction (HP:0001658)	2.50435725
59	Abnormality of urine glucose concentration (HP:0011016)	2.44594259
60	Glycosuria (HP:0003076)	2.44594259
61	Hypochromic microcytic anemia (HP:0004840)	2.39521966
62	Abnormal gallbladder morphology (HP:0012437)	2.38792659
63	Delayed CNS myelination (HP:0002188)	2.35887838
64	Cholelithiasis (HP:0001081)	2.34619018
65	Increased mean platelet volume (HP:0011877)	2.34177719
66	Spastic diplegia (HP:0001264)	2.31290841
67	Reticulocytosis (HP:0001923)	2.30896947
68	Cardiovascular calcification (HP:0011915)	2.30416544
69	Late onset (HP:0003584)	2.28317745
70	Gout (HP:0001997)	2.27805986
71	Sensorimotor neuropathy (HP:0007141)	2.25493364
72	Lethargy (HP:0001254)	2.24582640
73	Right ventricular cardiomyopathy (HP:0011663)	2.22958786
74	Abnormality of serum amino acid levels (HP:0003112)	2.21476986
75	Amyloidosis (HP:0011034)	2.21276634
76	Focal segmental glomerulosclerosis (HP:0000097)	2.16918873
77	Pancreatitis (HP:0001733)	2.13918698
78	Symptomatic seizures (HP:0011145)	2.11784169
79	Abdominal distention (HP:0003270)	2.11254378
80	Abnormality of vitamin metabolism (HP:0100508)	2.09302802
81	Potter facies (HP:0002009)	2.08169150
82	Facial shape deformation (HP:0011334)	2.08169150
83	Irritability (HP:0000737)	2.06119837
84	Dicarboxylic aciduria (HP:0003215)	2.05800147
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05800147
86	Abnormal platelet volume (HP:0011876)	2.03980151
87	Hyperinsulinemic hypoglycemia (HP:0000825)	2.02077948
88	Hemorrhage of the eye (HP:0011885)	2.01683809
89	Rickets (HP:0002748)	2.01507216
90	Abnormality of transition element cation homeostasis (HP:0011030)	2.01474529
91	Gingival bleeding (HP:0000225)	2.00920076
92	Glomerulosclerosis (HP:0000096)	2.00179695
93	Nephrolithiasis (HP:0000787)	1.95200423
94	Abnormality of the gallbladder (HP:0005264)	1.93759228
95	Polycythemia (HP:0001901)	1.92640987
96	Proximal tubulopathy (HP:0000114)	1.90726150
97	Abnormal cartilage morphology (HP:0002763)	1.89796172
98	Glomerulonephritis (HP:0000099)	1.88329571
99	Confusion (HP:0001289)	1.84149759
100	Abnormality of iron homeostasis (HP:0011031)	1.83862399

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.92724673
2	MST1R	4.05254984
3	MST4	3.72870802
4	EPHA2	3.60638416
5	ERN1	3.43410363
6	BCKDK	3.41551657
7	SIK1	2.67572045
8	PTK6	2.55945785
9	FGFR4	2.55902549
10	TAOK3	2.44758809
11	LMTK2	2.39476377
12	GRK6	2.39254332
13	PRKG2	2.34716751
14	ERBB4	2.12526123
15	MET	2.11506456
16	MAP3K10	1.88222517
17	INSRR	1.75985567
18	PKN2	1.71440471
19	RIPK1	1.69892644
20	MAP3K2	1.67783072
21	LATS1	1.67608778
22	MAP2K2	1.56015204
23	MAPK11	1.50388324
24	FLT3	1.45838791
25	TBK1	1.40500101
26	PTK2	1.30725192
27	MAP2K4	1.25113993
28	TRIB3	1.19707607
29	MAP3K7	1.18158146
30	NUAK1	1.16211448
31	FER	1.10265298
32	PRKAA2	1.09301428
33	ERBB2	1.07455233
34	PBK	1.06880048
35	NEK9	1.05824187
36	EPHB2	1.03340032
37	NME1	1.02867260
38	PIK3CG	1.02251330
39	STK10	1.02108787
40	CDK6	0.97250178
41	MAP2K6	0.92836881
42	MAP2K1	0.88837653
43	MAP3K3	0.88424589
44	TYK2	0.87670917
45	DYRK1B	0.87271513
46	ICK	0.85421225
47	EPHB1	0.80850260
48	MAP3K11	0.79168582
49	ABL2	0.78486505
50	MAP3K14	0.76516871
51	DAPK2	0.76305766
52	MAP3K8	0.75167068
53	CSK	0.67417387
54	CAMK2G	0.67357948
55	PRKCQ	0.66255632
56	PDPK1	0.65770814
57	AKT3	0.65661350
58	BMX	0.64650703
59	JAK2	0.64572272
60	AKT2	0.64329572
61	STK3	0.62272089
62	PAK4	0.58959253
63	PDGFRA	0.57672546
64	GSK3A	0.56669492
65	LRRK2	0.55704562
66	PRKACG	0.54641408
67	PRKAA1	0.54590265
68	PRKCZ	0.54515052
69	JAK1	0.53828542
70	PRKCI	0.51327214
71	BCR	0.49291845
72	CAMK1D	0.48718044
73	GRK1	0.48220061
74	PAK3	0.48180335
75	MAP3K6	0.46175470
76	MAP3K1	0.46053459
77	KDR	0.44628951
78	MAPK4	0.43492497
79	STK38L	0.43167632
80	MAP3K13	0.41698519
81	MAPK15	0.40650286
82	FGR	0.40126160
83	MAP3K5	0.39959878
84	JAK3	0.39869821
85	SCYL2	0.39271590
86	TESK2	0.34198299
87	PDK1	0.33850306
88	EGFR	0.33117330
89	PRKCA	0.29970382
90	KSR2	0.28950062
91	MATK	0.27090607
92	CSNK1G1	0.26474328
93	DDR2	0.25896461
94	CSNK1A1L	0.25501611
95	SRC	0.24698160
96	IRAK3	0.23452947
97	CAMK2B	0.22494598
98	PAK2	0.21734819
99	PRKCD	0.21722094
100	ABL1	0.21416847

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.53707347
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.50308283
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.46965340
4	Fat digestion and absorption_Homo sapiens_hsa04975	3.05358924
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.92263964
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.69601658
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.52358797
8	Fatty acid degradation_Homo sapiens_hsa00071	2.47667604
9	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.26714641
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.20882680
11	Complement and coagulation cascades_Homo sapiens_hsa04610	2.19763762
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.18285368
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.13002821
14	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.09141067
15	Histidine metabolism_Homo sapiens_hsa00340	2.07609636
16	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.06581204
17	Caffeine metabolism_Homo sapiens_hsa00232	2.04501495
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.01560137
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.95225710
20	Bile secretion_Homo sapiens_hsa04976	1.86914346
21	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.84730632
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.84006297
23	Butanoate metabolism_Homo sapiens_hsa00650	1.80237170
24	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.73562285
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.72357644
26	Chemical carcinogenesis_Homo sapiens_hsa05204	1.71827969
27	Peroxisome_Homo sapiens_hsa04146	1.71630432
28	Folate biosynthesis_Homo sapiens_hsa00790	1.66988728
29	Fatty acid metabolism_Homo sapiens_hsa01212	1.66146834
30	Retinol metabolism_Homo sapiens_hsa00830	1.63603646
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.63366480
32	Sulfur metabolism_Homo sapiens_hsa00920	1.59780940
33	Propanoate metabolism_Homo sapiens_hsa00640	1.59404311
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.58367433
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.57380678
36	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.55744597
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50167982
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.36680447
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.35927727
40	Selenocompound metabolism_Homo sapiens_hsa00450	1.34003685
41	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.30093356
42	ABC transporters_Homo sapiens_hsa02010	1.28364507
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.28327634
44	Phenylalanine metabolism_Homo sapiens_hsa00360	1.27191665
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24206405
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.21905008
47	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21380706
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.20542740
49	Renin-angiotensin system_Homo sapiens_hsa04614	1.16983747
50	Mineral absorption_Homo sapiens_hsa04978	1.16770722
51	Carbon metabolism_Homo sapiens_hsa01200	1.15889615
52	Arginine and proline metabolism_Homo sapiens_hsa00330	1.11259634
53	Tyrosine metabolism_Homo sapiens_hsa00350	1.09260149
54	Glycerolipid metabolism_Homo sapiens_hsa00561	1.05529993
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03266236
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.00682738
57	Fatty acid elongation_Homo sapiens_hsa00062	1.00264725
58	Glutathione metabolism_Homo sapiens_hsa00480	0.99645056
59	Galactose metabolism_Homo sapiens_hsa00052	0.97896642
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.93292352
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90924652
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88392187
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84752064
64	Lysine degradation_Homo sapiens_hsa00310	0.77164929
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.70052918
66	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.69314294
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.66846378
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.65121139
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.65084679
70	Sulfur relay system_Homo sapiens_hsa04122	0.60855115
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.55044248
72	One carbon pool by folate_Homo sapiens_hsa00670	0.53249873
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.52514904
74	Metabolic pathways_Homo sapiens_hsa01100	0.44559051
75	Protein digestion and absorption_Homo sapiens_hsa04974	0.44504595
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41293860
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35216101
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.26253485
79	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.12070056
80	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.11739595
81	Insulin resistance_Homo sapiens_hsa04931	0.11296676
82	Bladder cancer_Homo sapiens_hsa05219	0.10293025
83	Prion diseases_Homo sapiens_hsa05020	0.05310581
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.04740729
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.03510648
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.00748876
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.00594011
88	African trypanosomiasis_Homo sapiens_hsa05143	0.00267863
89	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1881320
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.1642842
91	Amoebiasis_Homo sapiens_hsa05146	-0.1393684
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1178955
93	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.1066817
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.0998439
95	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0826762
96	Thyroid cancer_Homo sapiens_hsa05216	-0.0817421
97	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0794965
98	Hepatitis C_Homo sapiens_hsa05160	-0.0573221
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	-0.0387627
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.0063738

GIMD1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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