GIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)5.22389933
2response to pheromone (GO:0019236)5.03484983
3daunorubicin metabolic process (GO:0044597)4.66970299
4polyketide metabolic process (GO:0030638)4.66970299
5doxorubicin metabolic process (GO:0044598)4.66970299
6centriole assembly (GO:0098534)4.10132051
7protein complex biogenesis (GO:0070271)4.02522760
8G-protein coupled receptor internalization (GO:0002031)3.86479861
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80497585
10DNA deamination (GO:0045006)3.75464601
11mitochondrial respiratory chain complex assembly (GO:0033108)3.75460115
12adenosine metabolic process (GO:0046085)3.74616614
13proteasome assembly (GO:0043248)3.73563655
14negative regulation of DNA-dependent DNA replication (GO:2000104)3.71980807
15NADH dehydrogenase complex assembly (GO:0010257)3.66931828
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66931828
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.66931828
18DNA double-strand break processing (GO:0000729)3.62835969
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44603097
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44603097
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39914221
22protein localization to cilium (GO:0061512)3.39771384
23protein-cofactor linkage (GO:0018065)3.36562115
24mesenchymal cell differentiation involved in kidney development (GO:0072161)3.35703505
25mesenchymal cell differentiation involved in renal system development (GO:2001012)3.35703505
26androgen biosynthetic process (GO:0006702)3.35405220
27energy homeostasis (GO:0097009)3.32477778
28water-soluble vitamin biosynthetic process (GO:0042364)3.31597382
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24543004
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22934704
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.22437812
32epithelial cilium movement (GO:0003351)3.21223263
33cilium morphogenesis (GO:0060271)3.18776331
34DNA strand renaturation (GO:0000733)3.18577734
35cytidine metabolic process (GO:0046087)3.17733520
36cytidine catabolic process (GO:0006216)3.17733520
37cytidine deamination (GO:0009972)3.17733520
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.17101661
39protein neddylation (GO:0045116)3.16986059
40regulation of DNA endoreduplication (GO:0032875)3.16693884
41synapsis (GO:0007129)3.13617779
42positive regulation of uterine smooth muscle contraction (GO:0070474)3.06525790
43preassembly of GPI anchor in ER membrane (GO:0016254)3.06414249
44behavioral response to nicotine (GO:0035095)3.05308972
45superoxide metabolic process (GO:0006801)3.04044110
46negative regulation of mast cell activation (GO:0033004)3.03323130
47detection of other organism (GO:0098543)3.02019962
48negative regulation of keratinocyte proliferation (GO:0010839)3.01397602
49kinetochore assembly (GO:0051382)2.99858013
50cullin deneddylation (GO:0010388)2.99085958
51righting reflex (GO:0060013)2.98781588
52neural tube formation (GO:0001841)2.97344716
53auditory receptor cell stereocilium organization (GO:0060088)2.97203438
54platelet dense granule organization (GO:0060155)2.96859994
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96025143
56cilium or flagellum-dependent cell motility (GO:0001539)2.95707453
57opioid receptor signaling pathway (GO:0038003)2.95430072
58sequestering of actin monomers (GO:0042989)2.94572672
59meiotic chromosome segregation (GO:0045132)2.93178165
60somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92628009
61somatic hypermutation of immunoglobulin genes (GO:0016446)2.92628009
62regulation of non-canonical Wnt signaling pathway (GO:2000050)2.92620541
63detection of bacterium (GO:0016045)2.91753146
64regulation of activation of Janus kinase activity (GO:0010533)2.91059328
65reflex (GO:0060004)2.91012946
66replication fork processing (GO:0031297)2.90754405
67replicative senescence (GO:0090399)2.89831986
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88881291
69DNA synthesis involved in DNA repair (GO:0000731)2.86466879
70intraciliary transport (GO:0042073)2.83604054
71female gonad development (GO:0008585)2.81254444
72S-adenosylmethionine metabolic process (GO:0046500)2.79949748
73centriole replication (GO:0007099)2.79251310
74sulfate transport (GO:0008272)2.78709461
75resolution of meiotic recombination intermediates (GO:0000712)2.78462695
76regulation of meiosis I (GO:0060631)2.78400756
77positive regulation of cellular amide metabolic process (GO:0034250)2.78304990
78extracellular regulation of signal transduction (GO:1900115)2.77157438
79extracellular negative regulation of signal transduction (GO:1900116)2.77157438
80protein deneddylation (GO:0000338)2.76137772
81protein K6-linked ubiquitination (GO:0085020)2.75914509
82microtubule depolymerization (GO:0007019)2.75642182
83nucleotide transmembrane transport (GO:1901679)2.75488500
84mannosylation (GO:0097502)2.75399341
85maturation of 5.8S rRNA (GO:0000460)2.75358390
86purine ribonucleotide transport (GO:0015868)2.75096910
87cilium organization (GO:0044782)2.74277304
88respiratory electron transport chain (GO:0022904)2.73794934
89pyrimidine ribonucleoside catabolic process (GO:0046133)2.72966388
90electron transport chain (GO:0022900)2.72683199
91negative regulation of granulocyte differentiation (GO:0030853)2.71611962
92cilium movement (GO:0003341)2.71445697
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71033457
94startle response (GO:0001964)2.70914412
95inner ear receptor stereocilium organization (GO:0060122)2.70429247
96adenine nucleotide transport (GO:0051503)2.70354356
97recombinational repair (GO:0000725)2.70153694
98double-strand break repair via homologous recombination (GO:0000724)2.68892106
99GPI anchor biosynthetic process (GO:0006506)2.68750483
100presynaptic membrane assembly (GO:0097105)2.68656240
101rRNA catabolic process (GO:0016075)2.68585416
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68461224
103piRNA metabolic process (GO:0034587)2.66572422
104axoneme assembly (GO:0035082)2.66241004
105cilium assembly (GO:0042384)2.66134900
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64879108
107protein heterotetramerization (GO:0051290)2.64793882
108retinal cone cell development (GO:0046549)2.64647598
109transcription elongation from RNA polymerase III promoter (GO:0006385)2.64302359
110termination of RNA polymerase III transcription (GO:0006386)2.64302359
111DNA ligation (GO:0006266)2.63765406
112motile cilium assembly (GO:0044458)2.63488489
113positive regulation of protein homodimerization activity (GO:0090073)2.63256667
114aminoglycoside antibiotic metabolic process (GO:0030647)2.63072900
115regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61957065
116tRNA methylation (GO:0030488)2.61622378
117kynurenine metabolic process (GO:0070189)2.61237791
118indole-containing compound catabolic process (GO:0042436)2.61078212
119indolalkylamine catabolic process (GO:0046218)2.61078212
120tryptophan catabolic process (GO:0006569)2.61078212
121energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60080993
122ATP synthesis coupled proton transport (GO:0015986)2.60080993
123regulation of cilium movement (GO:0003352)2.59894894
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59654994
125regulation of mitotic spindle checkpoint (GO:1903504)2.59654994
126DNA demethylation (GO:0080111)2.59286518
127ubiquinone metabolic process (GO:0006743)2.58463158
128cell differentiation involved in metanephros development (GO:0072202)2.57829556
129intra-S DNA damage checkpoint (GO:0031573)2.57825296
130protein K11-linked deubiquitination (GO:0035871)2.57817401
131dendritic cell chemotaxis (GO:0002407)2.57797151
132developmental pigmentation (GO:0048066)2.57518712
133sulfate transmembrane transport (GO:1902358)2.56862335
134regulation of timing of cell differentiation (GO:0048505)2.56848581
135sphingoid metabolic process (GO:0046519)2.55668325
136chromatin remodeling at centromere (GO:0031055)2.55474845
137kinetochore organization (GO:0051383)2.55233341
138positive regulation of interleukin-1 beta secretion (GO:0050718)2.55206639
139ubiquinone biosynthetic process (GO:0006744)2.54768041
140reciprocal DNA recombination (GO:0035825)2.54740178
141reciprocal meiotic recombination (GO:0007131)2.54740178
142androgen metabolic process (GO:0008209)2.54343016
143GPI anchor metabolic process (GO:0006505)2.53678740
144detection of molecule of bacterial origin (GO:0032490)2.53629736
145cytochrome complex assembly (GO:0017004)2.53033163
146hepatocyte differentiation (GO:0070365)2.52961281
147response to X-ray (GO:0010165)2.51454410
148sphingosine metabolic process (GO:0006670)2.49749085
149dendritic cell migration (GO:0036336)2.49480338
150pseudouridine synthesis (GO:0001522)2.49230938
151protein polyglutamylation (GO:0018095)2.48500292
152fucose catabolic process (GO:0019317)2.47946813
153L-fucose metabolic process (GO:0042354)2.47946813
154L-fucose catabolic process (GO:0042355)2.47946813
155negative regulation of myoblast differentiation (GO:0045662)2.47269851
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.46536681
157male meiosis (GO:0007140)2.46245431
158regulation of glucokinase activity (GO:0033131)2.45774035
159regulation of hexokinase activity (GO:1903299)2.45774035
160lymphoid progenitor cell differentiation (GO:0002320)2.45466113
161photoreceptor cell development (GO:0042461)2.45124117
162amino acid salvage (GO:0043102)2.44535133
163L-methionine salvage (GO:0071267)2.44535133
164L-methionine biosynthetic process (GO:0071265)2.44535133
165C-terminal protein lipidation (GO:0006501)2.43144817
166C-terminal protein amino acid modification (GO:0018410)2.42537606
167regulation of acyl-CoA biosynthetic process (GO:0050812)2.42500943
168NAD biosynthetic process (GO:0009435)2.41613140
169cellular anion homeostasis (GO:0030002)2.41536796
170DNA damage response, detection of DNA damage (GO:0042769)2.41096741
171prostate gland growth (GO:0060736)2.40552936
172respiratory chain complex IV assembly (GO:0008535)2.40060502
173photoreceptor cell maintenance (GO:0045494)2.39058506
174positive regulation of protein sumoylation (GO:0033235)2.38443659
175regulation of mitochondrial translation (GO:0070129)2.37777507
176negative regulation of transcription by competitive promoter binding (GO:0010944)2.37238065
177left/right axis specification (GO:0070986)2.36318663
178diol metabolic process (GO:0034311)2.34817171
179cellular response to gamma radiation (GO:0071480)2.34374139
180regulation of interleukin-8 secretion (GO:2000482)2.33557127
181detection of external biotic stimulus (GO:0098581)2.33530183
182dentate gyrus development (GO:0021542)2.33388677
183mesenchymal cell differentiation (GO:0048762)2.33350851
184nonmotile primary cilium assembly (GO:0035058)2.33146080
185positive regulation of interleukin-1 secretion (GO:0050716)2.31732244
186DNA catabolic process, exonucleolytic (GO:0000738)2.29527522
187glucocorticoid biosynthetic process (GO:0006704)2.28876205

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.02245960
2* PCGF2_27294783_Chip-Seq_ESCs_Mouse3.32635719
3ZNF274_21170338_ChIP-Seq_K562_Hela3.23678409
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.22245528
5* ZFP57_27257070_Chip-Seq_ESCs_Mouse3.09885087
6* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.80087926
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73778152
8* PCGF2_27294783_Chip-Seq_NPCs_Mouse2.72041219
9* NFE2_27457419_Chip-Seq_LIVER_Mouse2.70650386
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.65807835
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56696025
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.51777250
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42608783
14* EZH2_27294783_Chip-Seq_NPCs_Mouse2.38067524
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31940875
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26186128
17EZH2_22144423_ChIP-Seq_EOC_Human2.21690380
18* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.20496671
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19168347
20IGF1R_20145208_ChIP-Seq_DFB_Human2.16172825
21* P53_22387025_ChIP-Seq_ESCs_Mouse2.15753698
22ELK1_19687146_ChIP-ChIP_HELA_Human2.15232818
23* SUZ12_18555785_Chip-Seq_ESCs_Mouse2.11903618
24* STAT3_18555785_Chip-Seq_ESCs_Mouse2.11644416
25* NANOG_18555785_Chip-Seq_ESCs_Mouse2.11486389
26* E2F1_18555785_Chip-Seq_ESCs_Mouse2.07908779
27* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.06317436
28* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse2.01463894
29* NMYC_18555785_Chip-Seq_ESCs_Mouse1.99921673
30TAF15_26573619_Chip-Seq_HEK293_Human1.94853191
31* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.91439612
32* P300_18555785_Chip-Seq_ESCs_Mouse1.90974283
33* CMYC_18555785_Chip-Seq_ESCs_Mouse1.90611918
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89767672
35* OCT4_18555785_Chip-Seq_ESCs_Mouse1.88607329
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.86078176
37FUS_26573619_Chip-Seq_HEK293_Human1.81603684
38* ZFX_18555785_Chip-Seq_ESCs_Mouse1.81244786
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80477150
40* SOX2_18555785_Chip-Seq_ESCs_Mouse1.79715813
41* PU1_27457419_Chip-Seq_LIVER_Mouse1.78029811
42P300_19829295_ChIP-Seq_ESCs_Human1.74401315
43* KLF4_18555785_Chip-Seq_ESCs_Mouse1.74167223
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73649268
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.72599697
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72496848
47* VDR_23849224_ChIP-Seq_CD4+_Human1.71207837
48* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.69566242
49* CRX_20693478_ChIP-Seq_RETINA_Mouse1.68760167
50* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.67722078
51* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.67579918
52* CTCF_18555785_Chip-Seq_ESCs_Mouse1.64254516
53* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.63541634
54MYC_18940864_ChIP-ChIP_HL60_Human1.61755210
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60218385
56EWS_26573619_Chip-Seq_HEK293_Human1.60037118
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58501038
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57173582
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55736397
60* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.54846092
61RNF2_27304074_Chip-Seq_NSC_Mouse1.54204492
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53735050
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53103916
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.52419115
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52044272
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.51934081
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50437848
68CBP_20019798_ChIP-Seq_JUKART_Human1.50437848
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47770836
70VDR_22108803_ChIP-Seq_LS180_Human1.46026453
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44841021
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43863516
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43633822
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41427574
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40759527
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39089050
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39002392
78SMAD4_21799915_ChIP-Seq_A2780_Human1.37127111
79ER_23166858_ChIP-Seq_MCF-7_Human1.37117314
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36317626
81* ETS1_20019798_ChIP-Seq_JURKAT_Human1.35234231
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34982654
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.33164167
84TP53_22573176_ChIP-Seq_HFKS_Human1.32654515
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31250635
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29700986
87NANOG_19829295_ChIP-Seq_ESCs_Human1.29119190
88SOX2_19829295_ChIP-Seq_ESCs_Human1.29119190
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28648679
90KDM2B_26808549_Chip-Seq_REH_Human1.28180524
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28102796
92BCAT_22108803_ChIP-Seq_LS180_Human1.28058395
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27811069
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26744780
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25868248
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24548147
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24398264
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24257486
99IRF1_19129219_ChIP-ChIP_H3396_Human1.24162266
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.23060930
101AR_25329375_ChIP-Seq_VCAP_Human1.22984415
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22477719
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22075938
104TCF4_22108803_ChIP-Seq_LS180_Human1.21021352
105STAT3_23295773_ChIP-Seq_U87_Human1.20852070
106JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19235645
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.18420228
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18352849
109HTT_18923047_ChIP-ChIP_STHdh_Human1.17638974
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17579255
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.17199778
112TCF4_23295773_ChIP-Seq_U87_Human1.16422576
113LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15934128
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.15367189
115SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14334989
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13813031
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.12794694
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12284162
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09921039
120* FOXP3_21729870_ChIP-Seq_TREG_Human1.09902236
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09651342
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09651342
123TP53_18474530_ChIP-ChIP_U2OS_Human1.09385004
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09243744
125BP1_19119308_ChIP-ChIP_Hs578T_Human1.09163360
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09017013
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08220124
128POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08190063
129RUNX2_22187159_ChIP-Seq_PCA_Human1.07321340
130FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06346387
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.06346387
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05530906
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04942159
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04413142
135SALL1_21062744_ChIP-ChIP_HESCs_Human1.04098673
136STAT1_17558387_ChIP-Seq_HELA_Human1.04042965
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03402047
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02095507
139FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01568695
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99495488
141CDX2_22108803_ChIP-Seq_LS180_Human0.98390538
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96340379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.93472648
2MP0002102_abnormal_ear_morphology3.28387406
3MP0000566_synostosis3.27999621
4MP0006292_abnormal_olfactory_placode3.10090655
5MP0003136_yellow_coat_color2.94463976
6MP0001986_abnormal_taste_sensitivity2.89486174
7MP0006072_abnormal_retinal_apoptosis2.84357208
8MP0008058_abnormal_DNA_repair2.71886530
9MP0005645_abnormal_hypothalamus_physiol2.68112302
10MP0000015_abnormal_ear_pigmentation2.60640703
11MP0005409_darkened_coat_color2.59276965
12MP0004381_abnormal_hair_follicle2.42858317
13MP0009697_abnormal_copulation2.42217450
14MP0005171_absent_coat_pigmentation2.30085124
15MP0002876_abnormal_thyroid_physiology2.18043942
16MP0002277_abnormal_respiratory_mucosa2.14109303
17MP0005174_abnormal_tail_pigmentation2.06080886
18MP0005646_abnormal_pituitary_gland2.05164152
19MP0002837_dystrophic_cardiac_calcinosis1.88193651
20MP0003787_abnormal_imprinting1.79046302
21MP0009046_muscle_twitch1.78461863
22MP0010386_abnormal_urinary_bladder1.77420841
23MP0002653_abnormal_ependyma_morphology1.76311182
24MP0002638_abnormal_pupillary_reflex1.70643784
25MP0008260_abnormal_autophagy1.70606772
26MP0002132_abnormal_respiratory_system1.67875860
27MP0008789_abnormal_olfactory_epithelium1.67436578
28MP0008995_early_reproductive_senescence1.66655984
29MP0005379_endocrine/exocrine_gland_phen1.66536641
30MP0002095_abnormal_skin_pigmentation1.63939875
31MP0006035_abnormal_mitochondrial_morpho1.63588098
32MP0001485_abnormal_pinna_reflex1.53864132
33MP0003121_genomic_imprinting1.53835672
34MP0005451_abnormal_body_composition1.53050736
35MP0002396_abnormal_hematopoietic_system1.52042392
36MP0003890_abnormal_embryonic-extraembry1.49856689
37MP0004215_abnormal_myocardial_fiber1.49732659
38MP0003941_abnormal_skin_development1.49714697
39MP0000569_abnormal_digit_pigmentation1.49704080
40MP0005075_abnormal_melanosome_morpholog1.47468132
41MP0001835_abnormal_antigen_presentation1.42978110
42MP0001346_abnormal_lacrimal_gland1.41730573
43MP0004885_abnormal_endolymph1.41691428
44MP0003786_premature_aging1.40863674
45MP0000631_abnormal_neuroendocrine_gland1.39430719
46MP0003646_muscle_fatigue1.39230651
47MP0002234_abnormal_pharynx_morphology1.38997042
48MP0000372_irregular_coat_pigmentation1.38261126
49MP0000383_abnormal_hair_follicle1.37231286
50MP0000427_abnormal_hair_cycle1.35447131
51MP0002148_abnormal_hypersensitivity_rea1.35183174
52MP0003724_increased_susceptibility_to1.34788551
53MP0004742_abnormal_vestibular_system1.33250405
54MP0008057_abnormal_DNA_replication1.32621285
55MP0009379_abnormal_foot_pigmentation1.32337259
56MP0006036_abnormal_mitochondrial_physio1.31991673
57MP0004147_increased_porphyrin_level1.30869506
58MP0002272_abnormal_nervous_system1.29814172
59MP0004924_abnormal_behavior1.29234062
60MP0005386_behavior/neurological_phenoty1.29234062
61MP0003195_calcinosis1.28347994
62MP0009785_altered_susceptibility_to1.27951930
63MP0001486_abnormal_startle_reflex1.27210646
64MP0009745_abnormal_behavioral_response1.25013156
65MP0002735_abnormal_chemical_nociception1.23282574
66MP0002938_white_spotting1.21243318
67MP0003937_abnormal_limbs/digits/tail_de1.20966561
68MP0004133_heterotaxia1.20963727
69MP0009764_decreased_sensitivity_to1.19278962
70MP0005499_abnormal_olfactory_system1.19122200
71MP0005394_taste/olfaction_phenotype1.19122200
72MP0000026_abnormal_inner_ear1.19088342
73MP0002822_catalepsy1.18429245
74MP0000678_abnormal_parathyroid_gland1.17238122
75MP0005671_abnormal_response_to1.17177608
76MP0002163_abnormal_gland_morphology1.17038371
77MP0005647_abnormal_sex_gland1.15718637
78MP0004043_abnormal_pH_regulation1.14791597
79MP0002751_abnormal_autonomic_nervous1.14707056
80MP0005387_immune_system_phenotype1.12685510
81MP0001790_abnormal_immune_system1.12685510
82MP0001293_anophthalmia1.12148874
83MP0000579_abnormal_nail_morphology1.10496669
84MP0010094_abnormal_chromosome_stability1.10208551
85MP0005084_abnormal_gallbladder_morpholo1.09913619
86MP0005195_abnormal_posterior_eye1.08658897
87MP0003122_maternal_imprinting1.08467321
88MP0000681_abnormal_thyroid_gland1.07220432
89MP0006276_abnormal_autonomic_nervous1.06900153
90MP0004782_abnormal_surfactant_physiolog1.06793553
91MP0000490_abnormal_crypts_of1.06102398
92MP0004019_abnormal_vitamin_homeostasis1.06000507
93MP0001929_abnormal_gametogenesis1.04977231
94MP0002067_abnormal_sensory_capabilities1.03920047
95MP0000778_abnormal_nervous_system1.03440045
96MP0008004_abnormal_stomach_pH1.02827245
97MP0000647_abnormal_sebaceous_gland1.02609920
98MP0005391_vision/eye_phenotype1.01988701
99MP0005551_abnormal_eye_electrophysiolog1.01552656
100MP0001905_abnormal_dopamine_level1.00641234
101MP0001186_pigmentation_phenotype0.99632302
102MP0001919_abnormal_reproductive_system0.99236914
103MP0001963_abnormal_hearing_physiology0.98365351
104MP0005187_abnormal_penis_morphology0.98083643
105MP0008872_abnormal_physiological_respon0.97818926
106MP0003698_abnormal_male_reproductive0.97550255
107MP0003567_abnormal_fetal_cardiomyocyte0.97346811
108MP0002090_abnormal_vision0.96709060
109MP0004145_abnormal_muscle_electrophysio0.96378406
110MP0002752_abnormal_somatic_nervous0.95586368
111MP0008877_abnormal_DNA_methylation0.95206217
112MP0001984_abnormal_olfaction0.94597602
113MP0001502_abnormal_circadian_rhythm0.92990425
114MP0005389_reproductive_system_phenotype0.91662413
115MP0004484_altered_response_of0.91429011
116MP0003806_abnormal_nucleotide_metabolis0.91252518
117MP0000653_abnormal_sex_gland0.90458015
118MP0002572_abnormal_emotion/affect_behav0.90204863
119MP0005025_abnormal_response_to0.90180539
120MP0002233_abnormal_nose_morphology0.90086791
121MP0001324_abnormal_eye_pigmentation0.89620704
122MP0001119_abnormal_female_reproductive0.87955367
123MP0002138_abnormal_hepatobiliary_system0.87896737
124MP0002419_abnormal_innate_immunity0.87466025
125MP0002736_abnormal_nociception_after0.86875325
126MP0001145_abnormal_male_reproductive0.86803541
127MP0005253_abnormal_eye_physiology0.86673433
128MP0003137_abnormal_impulse_conducting0.85601826
129MP0002734_abnormal_mechanical_nocicepti0.84779562
130MP0004142_abnormal_muscle_tone0.84733154
131MP0001529_abnormal_vocalization0.84269015
132MP0001764_abnormal_homeostasis0.82698492
133MP0003011_delayed_dark_adaptation0.82595733
134MP0002282_abnormal_trachea_morphology0.81103268
135MP0001800_abnormal_humoral_immune0.80984876
136MP0003693_abnormal_embryo_hatching0.80665370
137MP0002064_seizures0.78929041
138MP0001970_abnormal_pain_threshold0.78879027
139MP0003950_abnormal_plasma_membrane0.78473418
140MP0003111_abnormal_nucleus_morphology0.77257373
141MP0002160_abnormal_reproductive_system0.77231445
142MP0002723_abnormal_immune_serum0.77203891
143MP0002928_abnormal_bile_duct0.75020599
144MP0003718_maternal_effect0.74395377
145MP0001968_abnormal_touch/_nociception0.74134125
146MP0002075_abnormal_coat/hair_pigmentati0.73940786
147MP0000470_abnormal_stomach_morphology0.73189567
148MP0000613_abnormal_salivary_gland0.72756098
149MP0002210_abnormal_sex_determination0.71549050
150MP0003868_abnormal_feces_composition0.71457915
151MP0003880_abnormal_central_pattern0.71395298
152MP0002452_abnormal_antigen_presenting0.70705608
153MP0001873_stomach_inflammation0.67750877
154MP0002177_abnormal_outer_ear0.67384862
155MP0001819_abnormal_immune_cell0.65730225
156MP0005377_hearing/vestibular/ear_phenot0.65116606

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.26016556
2Chromsome breakage (HP:0040012)5.60285548
3Duplicated collecting system (HP:0000081)3.65681963
4Prostate neoplasm (HP:0100787)3.61286203
5Renal cortical cysts (HP:0000803)3.50026014
6Abnormality of the renal collecting system (HP:0004742)3.47352303
7Acute necrotizing encephalopathy (HP:0006965)3.46844386
8Progressive macrocephaly (HP:0004481)3.20459658
9Febrile seizures (HP:0002373)3.20007003
10Acute encephalopathy (HP:0006846)3.13030958
11Mitochondrial inheritance (HP:0001427)3.09465764
12Abnormality of the preputium (HP:0100587)3.08163098
13Abnormality of DNA repair (HP:0003254)3.05678061
14Abnormal mitochondria in muscle tissue (HP:0008316)3.04799359
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.98904279
16Abnormality of the labia minora (HP:0012880)2.95549925
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.90656445
18Absent/shortened dynein arms (HP:0200106)2.90656445
19Gait imbalance (HP:0002141)2.89952236
20Congenital primary aphakia (HP:0007707)2.88458036
21Increased CSF lactate (HP:0002490)2.86216657
22Osteomalacia (HP:0002749)2.84679315
23Clubbing of toes (HP:0100760)2.80075756
24Reduced antithrombin III activity (HP:0001976)2.79592307
25Increased hepatocellular lipid droplets (HP:0006565)2.77180349
26Congenital sensorineural hearing impairment (HP:0008527)2.73864802
27Microvesicular hepatic steatosis (HP:0001414)2.72234115
28Lipid accumulation in hepatocytes (HP:0006561)2.70116326
29Upper limb muscle weakness (HP:0003484)2.69989714
30Tubulointerstitial nephritis (HP:0001970)2.69979458
31Meckel diverticulum (HP:0002245)2.69606844
32Abnormality of chromosome stability (HP:0003220)2.69476496
33Abnormal ciliary motility (HP:0012262)2.68995940
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.68294995
35True hermaphroditism (HP:0010459)2.64850110
36Septo-optic dysplasia (HP:0100842)2.64568608
37Decreased central vision (HP:0007663)2.59916270
38Nephrogenic diabetes insipidus (HP:0009806)2.59854164
39Genital tract atresia (HP:0001827)2.57994480
40Hypothermia (HP:0002045)2.55632899
41Abnormality of the ileum (HP:0001549)2.55256993
42Bile duct proliferation (HP:0001408)2.54302048
43Abnormal biliary tract physiology (HP:0012439)2.54302048
44Chronic hepatic failure (HP:0100626)2.54260970
45Colon cancer (HP:0003003)2.52147253
46Vaginal atresia (HP:0000148)2.47812775
47Abnormality of the renal cortex (HP:0011035)2.40582687
48Alveolar cell carcinoma (HP:0006519)2.39547025
49Abnormality of the prostate (HP:0008775)2.39506351
50Ectopic kidney (HP:0000086)2.37153643
51White forelock (HP:0002211)2.36724613
52Patchy hypopigmentation of hair (HP:0011365)2.35739224
53Pancreatic fibrosis (HP:0100732)2.32426486
54Abnormal respiratory motile cilium morphology (HP:0005938)2.30658840
55Abnormal respiratory epithelium morphology (HP:0012253)2.30658840
56Fair hair (HP:0002286)2.28385132
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26967030
58Hepatocellular necrosis (HP:0001404)2.26498598
59Duplication of thumb phalanx (HP:0009942)2.26212863
60Cystic liver disease (HP:0006706)2.24059354
613-Methylglutaconic aciduria (HP:0003535)2.23904397
62Sclerocornea (HP:0000647)2.23369395
63Type I transferrin isoform profile (HP:0003642)2.23237903
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20921840
65Progressive inability to walk (HP:0002505)2.20846283
66Cerebral edema (HP:0002181)2.19791829
67Abnormality of incisor morphology (HP:0011063)2.19741932
68Anencephaly (HP:0002323)2.19563758
69Male pseudohermaphroditism (HP:0000037)2.19518011
70Methylmalonic acidemia (HP:0002912)2.17394871
71Hypergonadotropic hypogonadism (HP:0000815)2.17148360
72Abnormal respiratory motile cilium physiology (HP:0012261)2.16535099
73Hypoplasia of the fovea (HP:0007750)2.16479167
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.16479167
75Congenital stationary night blindness (HP:0007642)2.15069510
76Aplasia cutis congenita (HP:0001057)2.14521538
77Optic nerve hypoplasia (HP:0000609)2.14487474
78Median cleft lip (HP:0000161)2.13482012
79Postaxial foot polydactyly (HP:0001830)2.11647888
80Congenital hepatic fibrosis (HP:0002612)2.11222994
81Abolished electroretinogram (ERG) (HP:0000550)2.08820896
82Hepatic necrosis (HP:0002605)2.07806286
83Postaxial hand polydactyly (HP:0001162)2.07618911
84Pancreatic cysts (HP:0001737)2.03238005
85Medial flaring of the eyebrow (HP:0010747)2.03133899
86Oligodactyly (hands) (HP:0001180)1.99998742
87Supernumerary spleens (HP:0009799)1.99408388
88Bifid tongue (HP:0010297)1.98942846
89Aplasia/Hypoplasia of the tibia (HP:0005772)1.98249308
90Optic disc pallor (HP:0000543)1.98134828
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97873012
92Abnormality of alanine metabolism (HP:0010916)1.97873012
93Hyperalaninemia (HP:0003348)1.97873012
94Protruding tongue (HP:0010808)1.93941170
95Increased serum lactate (HP:0002151)1.92895669
96Lactic acidosis (HP:0003128)1.92040951
97Abnormality of the renal medulla (HP:0100957)1.91943697
98Neoplasm of the tracheobronchial system (HP:0100552)1.91269381
99Preaxial hand polydactyly (HP:0001177)1.91258947
100Nephronophthisis (HP:0000090)1.89579221
101Parakeratosis (HP:0001036)1.89483521
102Poor coordination (HP:0002370)1.88886960
103Polydipsia (HP:0001959)1.88529241
104Abnormal drinking behavior (HP:0030082)1.88529241
105Bone marrow hypocellularity (HP:0005528)1.88406111
106Mesomelia (HP:0003027)1.88295786
107Chronic mucocutaneous candidiasis (HP:0002728)1.88213498
108Recurrent cutaneous fungal infections (HP:0011370)1.88213498
109Furrowed tongue (HP:0000221)1.87831337
110Cheilitis (HP:0100825)1.87320010
111Generalized hypopigmentation of hair (HP:0011358)1.87183399
112Dry hair (HP:0011359)1.86764360
113Oculomotor apraxia (HP:0000657)1.86657921
114Conical tooth (HP:0000698)1.86224259
115Oligohydramnios (HP:0001562)1.86130767
116Broad-based gait (HP:0002136)1.85855802
117Sloping forehead (HP:0000340)1.85621216
118Rhinitis (HP:0012384)1.83686985
119Distal lower limb muscle weakness (HP:0009053)1.82946597
120Retrobulbar optic neuritis (HP:0100654)1.82785018
121Optic neuritis (HP:0100653)1.82785018
122Pendular nystagmus (HP:0012043)1.82717455
123Conjugated hyperbilirubinemia (HP:0002908)1.82030599
124Short tibia (HP:0005736)1.81002016
125Narrow forehead (HP:0000341)1.80109722
126Duodenal stenosis (HP:0100867)1.80103629
127Small intestinal stenosis (HP:0012848)1.80103629
128Type II lissencephaly (HP:0007260)1.79727865
129Recurrent pneumonia (HP:0006532)1.79101402
130Abnormality of the carotid arteries (HP:0005344)1.78822950
131Tachypnea (HP:0002789)1.77316157
132Type 2 muscle fiber atrophy (HP:0003554)1.75649474
133Abnormal hair whorl (HP:0010721)1.75006601
134Attenuation of retinal blood vessels (HP:0007843)1.74546790
135Inability to walk (HP:0002540)1.74224072
136Aganglionic megacolon (HP:0002251)1.72728689
137Renal Fanconi syndrome (HP:0001994)1.71506326
138Gaze-evoked nystagmus (HP:0000640)1.71196867
139Hyperventilation (HP:0002883)1.70416673
140Abnormality of the columella (HP:0009929)1.70316847
141Increased intramyocellular lipid droplets (HP:0012240)1.69759918
142Tubular atrophy (HP:0000092)1.69593066
143Hyperglycinemia (HP:0002154)1.69323832
144Azoospermia (HP:0000027)1.68873270
145Abnormality of midbrain morphology (HP:0002418)1.68673944
146Molar tooth sign on MRI (HP:0002419)1.68673944
147Ectropion (HP:0000656)1.67556258
148Reticulocytopenia (HP:0001896)1.67397959
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67279105
150Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67279105
151Chronic diarrhea (HP:0002028)1.66812880
152Nephroblastoma (Wilms tumor) (HP:0002667)1.66016343
153Triphalangeal thumb (HP:0001199)1.66002513
154Absent thumb (HP:0009777)1.64100140
155Respiratory failure (HP:0002878)1.63444170
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63434869
157Thyroiditis (HP:0100646)1.62914844
158Keratoconus (HP:0000563)1.62027210
159Increased corneal curvature (HP:0100692)1.62027210
160Abnormality of the fovea (HP:0000493)1.61333662
161Lethargy (HP:0001254)1.60454529
162Astigmatism (HP:0000483)1.59883133
163Abnormal rod and cone electroretinograms (HP:0008323)1.59389841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.44860843
2STK163.21608536
3ZAK2.90517304
4TRIM282.73529831
5TXK2.72227946
6EIF2AK22.72007754
7TNIK2.46603878
8IRAK32.34383839
9MAP3K42.29649958
10INSRR2.23925699
11SIK32.20844044
12ADRBK22.14928500
13MAP3K142.12038327
14MKNK22.10959525
15BCR1.93067625
16GRK11.91248098
17IRAK41.80084904
18YES11.78287344
19BRSK21.72955685
20MAP4K21.69480997
21MAP2K71.66878380
22BUB11.64833004
23NUAK11.61483078
24BMPR1B1.57186280
25PRPF4B1.56324792
26BMPR21.53102612
27TEC1.51724140
28PLK41.39283491
29MUSK1.38089129
30CSNK1G21.38008039
31MKNK11.35331443
32PIK3CG1.34966912
33BRD41.30145743
34CSNK1G31.29170417
35AKT31.28280466
36VRK21.27167899
37NEK61.25982495
38STK391.25481369
39EIF2AK11.24936501
40PLK31.23647944
41CSNK1G11.23312846
42VRK11.19594997
43SGK21.17159939
44EPHA31.16109816
45STK38L1.12324856
46DYRK21.10584345
47CDK31.09821838
48IKBKE1.09598579
49SRPK11.08469916
50CSNK1A1L1.07671392
51FRK1.06634325
52WNK41.05431381
53NLK1.05180049
54PAK31.04877936
55CAMKK21.04521474
56OXSR10.99222705
57PHKG10.97841001
58PHKG20.97841001
59BLK0.97744072
60CCNB10.96391240
61TAF10.94798207
62EPHA40.94335958
63GRK70.93427935
64EIF2AK30.93067114
65LIMK10.91850063
66IKBKB0.90736928
67CDK80.90040952
68TAOK30.88415407
69MARK10.85927374
70IRAK10.84775720
71MAPK130.82656614
72TNK20.82264870
73FGFR20.81736447
74SIK20.81632423
75CLK10.81237562
76ATR0.79996556
77TTK0.77405509
78PINK10.75441791
79TGFBR10.72981457
80JAK30.72688493
81NME10.72166082
82PRKCE0.71492135
83KIT0.70366116
84RPS6KA50.70010128
85PKN10.69630946
86MAPKAPK30.67199846
87JAK10.66815359
88MAP3K120.65910302
89NEK10.64685095
90TAOK20.63585852
91STK40.63031001
92RPS6KA40.61965589
93TLK10.61814581
94LYN0.58884095
95PNCK0.58250031
96PIK3CA0.57748072
97CAMK2A0.56348334
98MAP2K40.54594552
99SGK4940.54371035
100SGK2230.54371035
101TIE10.54306440
102BCKDK0.52937041
103PBK0.51941946
104WEE10.50812248
105CHUK0.49808119
106EPHA20.47729691
107PLK20.46823649
108ADRBK10.46770501
109IRAK20.46097343
110ACVR1B0.45882799
111CAMK2D0.45257590
112ERBB30.45122117
113MAPK70.44938966
114PDK20.44484541
115MAPKAPK50.44381151
116TRPM70.44205561
117SGK10.43342019
118MINK10.43213785
119CHEK20.42730221
120CSNK1A10.42440455
121OBSCN0.42032060
122STK30.41915943
123MAP3K130.41400612
124PRKAA20.40912326
125STK240.40380295
126ATM0.39619967
127PRKCG0.39175610
128BRAF0.39000890
129WNK30.38983213
130PIM10.38853733
131NTRK30.38802321
132PLK10.38118911
133PRKACA0.37839785
134SYK0.37648485
135CDC70.37079525
136BTK0.35611487
137MST40.35497572
138BRSK10.35383790
139LATS10.35019679
140RPS6KB10.34741170
141CAMK10.34678190
142DYRK1A0.34618112
143FER0.34494595
144DYRK30.33818110
145PRKCQ0.33390884
146CSNK2A10.32424788
147PTK2B0.31578972
148FGFR10.31047605
149PRKACB0.29959687
150PASK0.28425785

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.43537984
2Proteasome_Homo sapiens_hsa030503.05199636
3Parkinsons disease_Homo sapiens_hsa050122.86063156
4Homologous recombination_Homo sapiens_hsa034402.68290724
5Non-homologous end-joining_Homo sapiens_hsa034502.50106536
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44372089
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.39385702
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24082876
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20934870
10Propanoate metabolism_Homo sapiens_hsa006402.13574673
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.07617793
12Autoimmune thyroid disease_Homo sapiens_hsa053202.03549750
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03433803
14Huntingtons disease_Homo sapiens_hsa050161.91615592
15Butanoate metabolism_Homo sapiens_hsa006501.84240106
16Allograft rejection_Homo sapiens_hsa053301.78445039
17Basal transcription factors_Homo sapiens_hsa030221.72626864
18Primary immunodeficiency_Homo sapiens_hsa053401.72063546
19Hematopoietic cell lineage_Homo sapiens_hsa046401.70386877
20Alzheimers disease_Homo sapiens_hsa050101.69322812
21Sphingolipid metabolism_Homo sapiens_hsa006001.67628527
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.67536988
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67229389
24Arachidonic acid metabolism_Homo sapiens_hsa005901.58300985
25Phototransduction_Homo sapiens_hsa047441.57076680
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54762335
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54221639
28Nicotine addiction_Homo sapiens_hsa050331.53698224
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52735140
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51581214
31Asthma_Homo sapiens_hsa053101.50055159
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49250856
33Selenocompound metabolism_Homo sapiens_hsa004501.49005612
34Vitamin digestion and absorption_Homo sapiens_hsa049771.48598133
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.47657431
36Nitrogen metabolism_Homo sapiens_hsa009101.47441449
37Graft-versus-host disease_Homo sapiens_hsa053321.47013457
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46125206
39Caffeine metabolism_Homo sapiens_hsa002321.44142674
40Cardiac muscle contraction_Homo sapiens_hsa042601.40432638
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39175618
42Mismatch repair_Homo sapiens_hsa034301.37781333
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36318138
44Measles_Homo sapiens_hsa051621.33321541
45Base excision repair_Homo sapiens_hsa034101.31359128
46Nucleotide excision repair_Homo sapiens_hsa034201.27195950
47Taste transduction_Homo sapiens_hsa047421.25303693
48Protein export_Homo sapiens_hsa030601.24070507
49Histidine metabolism_Homo sapiens_hsa003401.23526832
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.23074607
51Pyrimidine metabolism_Homo sapiens_hsa002401.23021929
52Retinol metabolism_Homo sapiens_hsa008301.21534749
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20348338
54ABC transporters_Homo sapiens_hsa020101.18736928
55RNA polymerase_Homo sapiens_hsa030201.16600258
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15855377
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.13711193
58Linoleic acid metabolism_Homo sapiens_hsa005911.13261378
59Other glycan degradation_Homo sapiens_hsa005111.13108168
60Steroid biosynthesis_Homo sapiens_hsa001001.11648120
61beta-Alanine metabolism_Homo sapiens_hsa004101.10492300
62Purine metabolism_Homo sapiens_hsa002301.10253085
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08230788
64RNA transport_Homo sapiens_hsa030131.06412031
65Herpes simplex infection_Homo sapiens_hsa051681.05179814
66DNA replication_Homo sapiens_hsa030301.01495566
67Collecting duct acid secretion_Homo sapiens_hsa049660.98842508
68Regulation of autophagy_Homo sapiens_hsa041400.98570458
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98560794
70Spliceosome_Homo sapiens_hsa030400.97445060
71Rheumatoid arthritis_Homo sapiens_hsa053230.97240706
72Sulfur metabolism_Homo sapiens_hsa009200.93420427
73Morphine addiction_Homo sapiens_hsa050320.90718005
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.90583954
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90532808
76Olfactory transduction_Homo sapiens_hsa047400.88938779
77Ether lipid metabolism_Homo sapiens_hsa005650.87668349
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86015498
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82707842
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82175865
81Malaria_Homo sapiens_hsa051440.81617482
82Ovarian steroidogenesis_Homo sapiens_hsa049130.80224523
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79905298
84Ribosome_Homo sapiens_hsa030100.79391530
85One carbon pool by folate_Homo sapiens_hsa006700.78946959
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78901710
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.77533971
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77169232
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76193351
90Type I diabetes mellitus_Homo sapiens_hsa049400.75074109
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74421707
92African trypanosomiasis_Homo sapiens_hsa051430.72518695
93Serotonergic synapse_Homo sapiens_hsa047260.72073937
94RNA degradation_Homo sapiens_hsa030180.69311241
95Vitamin B6 metabolism_Homo sapiens_hsa007500.68643312
96Folate biosynthesis_Homo sapiens_hsa007900.68565461
97GABAergic synapse_Homo sapiens_hsa047270.66514857
98Pyruvate metabolism_Homo sapiens_hsa006200.65793100
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65295464
100Chemical carcinogenesis_Homo sapiens_hsa052040.63143064
101Calcium signaling pathway_Homo sapiens_hsa040200.60795933
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60035011
103Influenza A_Homo sapiens_hsa051640.58727816
104Fatty acid metabolism_Homo sapiens_hsa012120.56358729
105Oocyte meiosis_Homo sapiens_hsa041140.56054755
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54826066
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53701439
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52683352
109Circadian rhythm_Homo sapiens_hsa047100.52077431
110Hedgehog signaling pathway_Homo sapiens_hsa043400.51522146
111Inositol phosphate metabolism_Homo sapiens_hsa005620.50408360
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.50116159
113TNF signaling pathway_Homo sapiens_hsa046680.49021894
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48911794
115Metabolic pathways_Homo sapiens_hsa011000.48071739
116Glutamatergic synapse_Homo sapiens_hsa047240.47754514
117Peroxisome_Homo sapiens_hsa041460.47577218
118Fatty acid elongation_Homo sapiens_hsa000620.46141623
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45607479
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45405617
121p53 signaling pathway_Homo sapiens_hsa041150.44563856
122Systemic lupus erythematosus_Homo sapiens_hsa053220.43078185
123Leishmaniasis_Homo sapiens_hsa051400.42770055
124Circadian entrainment_Homo sapiens_hsa047130.42561045
125Staphylococcus aureus infection_Homo sapiens_hsa051500.41755381
126Dopaminergic synapse_Homo sapiens_hsa047280.41276021
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40563885
128Phagosome_Homo sapiens_hsa041450.39920704
129Tyrosine metabolism_Homo sapiens_hsa003500.39106847
130Phenylalanine metabolism_Homo sapiens_hsa003600.38822574
131Arginine and proline metabolism_Homo sapiens_hsa003300.35164649
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35104485
133N-Glycan biosynthesis_Homo sapiens_hsa005100.32929772
134Cell cycle_Homo sapiens_hsa041100.31780101
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31058373
136Fatty acid degradation_Homo sapiens_hsa000710.30792254
137Insulin secretion_Homo sapiens_hsa049110.30251554
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29510611
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28683127
140Amphetamine addiction_Homo sapiens_hsa050310.28050610
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27252622
142Tryptophan metabolism_Homo sapiens_hsa003800.26472427
143Hepatitis C_Homo sapiens_hsa051600.26372886
144Oxidative phosphorylation_Homo sapiens_hsa001900.25742654
145mRNA surveillance pathway_Homo sapiens_hsa030150.25378745

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