GINS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)5.21098717
2telomere maintenance via semi-conservative replication (GO:0032201)5.04441569
3* DNA strand elongation (GO:0022616)4.93430603
4ribosomal small subunit assembly (GO:0000028)4.92581989
5ribosomal small subunit biogenesis (GO:0042274)4.90724398
6DNA replication initiation (GO:0006270)4.88465624
7DNA replication checkpoint (GO:0000076)4.86891664
8maturation of SSU-rRNA (GO:0030490)4.86696903
9viral transcription (GO:0019083)4.85800826
10translational termination (GO:0006415)4.75432102
11sister chromatid segregation (GO:0000819)4.55549449
12telomere maintenance via recombination (GO:0000722)4.54663449
13DNA unwinding involved in DNA replication (GO:0006268)4.43299729
14mitotic metaphase plate congression (GO:0007080)4.36079151
15mitotic recombination (GO:0006312)4.34639952
16ribosomal large subunit biogenesis (GO:0042273)4.28105997
17DNA deamination (GO:0045006)4.25670835
18nuclear pore complex assembly (GO:0051292)4.21447225
19CENP-A containing nucleosome assembly (GO:0034080)4.19541546
20translational elongation (GO:0006414)4.19143152
21kinetochore organization (GO:0051383)4.15977954
22chromatin remodeling at centromere (GO:0031055)4.15105891
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.09344677
24translational initiation (GO:0006413)4.07732690
25nucleotide-excision repair, DNA gap filling (GO:0006297)4.05808617
26formation of translation preinitiation complex (GO:0001731)4.04759769
27telomere maintenance via telomere lengthening (GO:0010833)4.02966358
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01974711
29nucleobase biosynthetic process (GO:0046112)4.00792293
30protein localization to kinetochore (GO:0034501)4.00149629
31nuclear pore organization (GO:0006999)3.98881555
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96608584
33kinetochore assembly (GO:0051382)3.96602592
34mitotic sister chromatid cohesion (GO:0007064)3.95340715
35cotranslational protein targeting to membrane (GO:0006613)3.93398353
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.92559755
37protein targeting to ER (GO:0045047)3.91228174
38DNA replication-dependent nucleosome organization (GO:0034723)3.88010296
39DNA replication-dependent nucleosome assembly (GO:0006335)3.88010296
40ribonucleoprotein complex biogenesis (GO:0022613)3.87864590
41DNA ligation (GO:0006266)3.80715986
42metaphase plate congression (GO:0051310)3.79892696
43DNA replication-independent nucleosome assembly (GO:0006336)3.79100227
44DNA replication-independent nucleosome organization (GO:0034724)3.79100227
45purine nucleobase biosynthetic process (GO:0009113)3.78492105
46cellular protein complex disassembly (GO:0043624)3.76871823
47viral life cycle (GO:0019058)3.71466442
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71018367
49protein localization to endoplasmic reticulum (GO:0070972)3.67924136
50protein localization to chromosome, centromeric region (GO:0071459)3.66877753
51L-serine metabolic process (GO:0006563)3.65061700
52regulation of centriole replication (GO:0046599)3.64772600
53spliceosomal snRNP assembly (GO:0000387)3.60190391
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.60098481
55transcription-coupled nucleotide-excision repair (GO:0006283)3.58152092
56rRNA processing (GO:0006364)3.55684319
57DNA double-strand break processing (GO:0000729)3.52314942
58regulation of chromosome segregation (GO:0051983)3.50352231
59attachment of spindle microtubules to kinetochore (GO:0008608)3.47246083
60establishment of chromosome localization (GO:0051303)3.46783710
61histone exchange (GO:0043486)3.46008104
62DNA topological change (GO:0006265)3.45918917
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.45032897
64protein complex localization (GO:0031503)3.44192674
65ribosome assembly (GO:0042255)3.43839290
66rRNA metabolic process (GO:0016072)3.43266290
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.41947706
68protein complex disassembly (GO:0043241)3.40339510
69ribosome biogenesis (GO:0042254)3.39126961
70double-strand break repair via nonhomologous end joining (GO:0006303)3.38961976
71non-recombinational repair (GO:0000726)3.38961976
72translation (GO:0006412)3.37631720
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37342701
74proteasome assembly (GO:0043248)3.37162927
75ATP-dependent chromatin remodeling (GO:0043044)3.35996978
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.35860300
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35860300
78mitotic spindle checkpoint (GO:0071174)3.35554264
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35474721
80heterochromatin organization (GO:0070828)3.34996675
81establishment of viral latency (GO:0019043)3.33338893
82meiotic chromosome segregation (GO:0045132)3.33332241
83replication fork processing (GO:0031297)3.31977508
84chromatin assembly or disassembly (GO:0006333)3.31154164
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.30962412
86positive regulation of chromosome segregation (GO:0051984)3.30813148
87folic acid-containing compound biosynthetic process (GO:0009396)3.30679357
88regulation of centrosome cycle (GO:0046605)3.28919139
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28024937
90mitotic nuclear envelope disassembly (GO:0007077)3.26480716
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25631218
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25631218
93DNA strand renaturation (GO:0000733)3.25498191
94chromosome segregation (GO:0007059)3.25389394
95rRNA modification (GO:0000154)3.23600607
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23434570
97macromolecular complex disassembly (GO:0032984)3.23069980
98mitotic sister chromatid segregation (GO:0000070)3.22196441
99transcription elongation from RNA polymerase III promoter (GO:0006385)3.21452212
100termination of RNA polymerase III transcription (GO:0006386)3.21452212
101regulation of mitotic sister chromatid separation (GO:0010965)3.21027308
102regulation of mitotic sister chromatid segregation (GO:0033047)3.21027308
103regulation of sister chromatid segregation (GO:0033045)3.21027308
104pore complex assembly (GO:0046931)3.20281269
105spliceosomal complex assembly (GO:0000245)3.20170855
106mitotic spindle assembly checkpoint (GO:0007094)3.19948823
107IMP metabolic process (GO:0046040)3.19704235
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18369096
109regulation of mitotic spindle checkpoint (GO:1903504)3.18369096
110nuclear-transcribed mRNA catabolic process (GO:0000956)3.18266050
111spindle assembly checkpoint (GO:0071173)3.17735702
112negative regulation of DNA-dependent DNA replication (GO:2000104)3.16636314
113protein localization to chromosome (GO:0034502)3.15024050
114regulation of spindle organization (GO:0090224)3.14140830
115cell cycle G1/S phase transition (GO:0044843)3.13485632
116G1/S transition of mitotic cell cycle (GO:0000082)3.13485632
1177-methylguanosine mRNA capping (GO:0006370)3.10509756
118termination of RNA polymerase I transcription (GO:0006363)3.10156222
119transcription elongation from RNA polymerase I promoter (GO:0006362)3.09024306
120translesion synthesis (GO:0019985)3.08294187
121chromosome condensation (GO:0030261)3.07528894
122negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07201944
123negative regulation of ligase activity (GO:0051352)3.07201944
124spindle checkpoint (GO:0031577)3.07166599
125regulation of sister chromatid cohesion (GO:0007063)3.06795300
126establishment of integrated proviral latency (GO:0075713)3.06153531
127DNA duplex unwinding (GO:0032508)3.05849495
128RNA capping (GO:0036260)3.04876878
1297-methylguanosine RNA capping (GO:0009452)3.04876878
130IMP biosynthetic process (GO:0006188)3.04310815
131mitotic chromosome condensation (GO:0007076)3.04200595
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03028301
133DNA geometric change (GO:0032392)3.02339500
134negative regulation of mRNA processing (GO:0050686)3.01678035
135mRNA catabolic process (GO:0006402)3.00750650
136cellular protein complex localization (GO:0034629)3.00593519
137postreplication repair (GO:0006301)3.00172393
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99779723
139cellular component biogenesis (GO:0044085)2.99629260
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99084942
141telomere maintenance (GO:0000723)2.98825547
142telomere organization (GO:0032200)2.98784158
143negative regulation of chromosome segregation (GO:0051985)2.98419200
144negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98279679
145negative regulation of sister chromatid segregation (GO:0033046)2.98279679
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.98279679
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98279679
148regulation of DNA endoreduplication (GO:0032875)2.98260503
149viral mRNA export from host cell nucleus (GO:0046784)2.97997949
150mismatch repair (GO:0006298)2.96418640
151membrane disassembly (GO:0030397)2.96391068
152nuclear envelope disassembly (GO:0051081)2.96391068
153base-excision repair (GO:0006284)2.95439432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42517484
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.40030614
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.14574315
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92508700
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65894969
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55350153
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25864920
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.20528823
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10338914
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.07163421
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98331887
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.96786692
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95873276
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91174224
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83567355
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.66765595
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60753609
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55580108
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54102775
20XRN2_22483619_ChIP-Seq_HELA_Human2.44117110
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30078241
22VDR_23849224_ChIP-Seq_CD4+_Human2.25047953
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18741397
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17756224
25AR_21909140_ChIP-Seq_LNCAP_Human2.17572072
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17021333
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.10033227
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07020516
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06935526
30DCP1A_22483619_ChIP-Seq_HELA_Human2.06448470
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04960641
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99473881
33FOXP3_21729870_ChIP-Seq_TREG_Human1.98736685
34* E2F1_21310950_ChIP-Seq_MCF-7_Human1.95273493
35* TTF2_22483619_ChIP-Seq_HELA_Human1.91593078
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83247605
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82016106
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81810180
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80332557
40GABP_19822575_ChIP-Seq_HepG2_Human1.79617927
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.77263863
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75909540
43ELK1_19687146_ChIP-ChIP_HELA_Human1.66601703
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63894066
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57482589
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52644409
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49447967
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47837588
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46284126
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.45797216
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44973179
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42654471
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41828991
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41743330
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35552456
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35365380
57CIITA_25753668_ChIP-Seq_RAJI_Human1.34033257
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.32418572
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.31418140
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.27939988
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26978413
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25965226
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25594160
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24893579
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24891696
66KDM5A_27292631_Chip-Seq_BREAST_Human1.23191971
67EWS_26573619_Chip-Seq_HEK293_Human1.19904335
68MYC_18940864_ChIP-ChIP_HL60_Human1.19165400
69* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17851217
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14538912
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14361882
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12063912
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11195152
74* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07953912
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07772687
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07643233
77* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05712077
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03579646
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02860221
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01144755
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98980460
82EGR1_19374776_ChIP-ChIP_THP-1_Human0.96173663
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96095585
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.94516503
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.94006654
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93491072
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93107646
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.93034570
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92425255
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91260437
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89807264
92ZNF274_21170338_ChIP-Seq_K562_Hela0.89514825
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89281202
94TFEB_21752829_ChIP-Seq_HELA_Human0.87848947
95IRF1_19129219_ChIP-ChIP_H3396_Human0.87729243
96FUS_26573619_Chip-Seq_HEK293_Human0.86858189
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86466206
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86307718
99MYC_22102868_ChIP-Seq_BL_Human0.85807496
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83560601
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83560601
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83560601
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83265141
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82505776
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81557427
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80654813
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79371730
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78353236
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77698999
110SPI1_23547873_ChIP-Seq_NB4_Human0.77565951
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76622151
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.75214717
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74696545
114* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74494804
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73604980
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71099836
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69399905
118CHD1_26751641_Chip-Seq_LNCaP_Human0.67568649
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.66664485
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66463797
121TCF3_18692474_ChIP-Seq_MESCs_Mouse0.64449169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.06265557
2MP0010094_abnormal_chromosome_stability5.01419469
3MP0003111_abnormal_nucleus_morphology4.91019704
4MP0004957_abnormal_blastocyst_morpholog4.59282522
5MP0003077_abnormal_cell_cycle4.18863630
6MP0008057_abnormal_DNA_replication4.00554663
7MP0008058_abnormal_DNA_repair3.82811399
8* MP0008932_abnormal_embryonic_tissue3.05040359
9MP0008007_abnormal_cellular_replicative2.73094031
10MP0003786_premature_aging2.40793378
11MP0003718_maternal_effect2.25496277
12MP0003123_paternal_imprinting2.22877047
13MP0008877_abnormal_DNA_methylation2.15086069
14MP0000350_abnormal_cell_proliferation2.10081175
15* MP0001730_embryonic_growth_arrest2.05306300
16MP0002396_abnormal_hematopoietic_system2.03830455
17MP0009379_abnormal_foot_pigmentation2.03209669
18MP0010030_abnormal_orbit_morphology1.90754488
19MP0000566_synostosis1.85157957
20MP0003315_abnormal_perineum_morphology1.83330238
21MP0000490_abnormal_crypts_of1.70482041
22MP0006292_abnormal_olfactory_placode1.56021001
23MP0001697_abnormal_embryo_size1.55950292
24MP0001672_abnormal_embryogenesis/_devel1.55563142
25MP0005380_embryogenesis_phenotype1.55563142
26MP0010307_abnormal_tumor_latency1.48138628
27MP0000313_abnormal_cell_death1.47164203
28MP0002085_abnormal_embryonic_tissue1.42994603
29MP0002697_abnormal_eye_size1.42476025
30* MP0002080_prenatal_lethality1.41105792
31MP0002210_abnormal_sex_determination1.39677016
32MP0002019_abnormal_tumor_incidence1.34472403
33MP0003984_embryonic_growth_retardation1.32225065
34MP0002102_abnormal_ear_morphology1.31602634
35MP0003136_yellow_coat_color1.30942193
36MP0002088_abnormal_embryonic_growth/wei1.28732379
37MP0003806_abnormal_nucleotide_metabolis1.27008155
38MP0010352_gastrointestinal_tract_polyps1.26758454
39MP0001529_abnormal_vocalization1.22254383
40MP0001145_abnormal_male_reproductive1.19015254
41MP0003567_abnormal_fetal_cardiomyocyte1.17012743
42MP0003941_abnormal_skin_development1.16319541
43MP0002132_abnormal_respiratory_system1.14130638
44MP0002084_abnormal_developmental_patter1.13469405
45MP0002254_reproductive_system_inflammat1.13075061
46MP0009333_abnormal_splenocyte_physiolog1.12891645
47MP0002009_preneoplasia1.11247519
48MP0001293_anophthalmia1.11107292
49MP0001929_abnormal_gametogenesis1.08742492
50MP0002086_abnormal_extraembryonic_tissu1.08582953
51MP0004808_abnormal_hematopoietic_stem1.06585480
52MP0003186_abnormal_redox_activity1.05442404
53MP0003121_genomic_imprinting1.04918470
54MP0003890_abnormal_embryonic-extraembry1.04016186
55MP0002938_white_spotting1.03232616
56MP0001346_abnormal_lacrimal_gland1.02933554
57MP0004197_abnormal_fetal_growth/weight/1.02404884
58MP0000653_abnormal_sex_gland1.02372417
59MP0002233_abnormal_nose_morphology1.01664746
60MP0009703_decreased_birth_body1.00409733
61MP0002160_abnormal_reproductive_system0.99646706
62MP0003938_abnormal_ear_development0.98483018
63MP0006072_abnormal_retinal_apoptosis0.98409601
64MP0005397_hematopoietic_system_phenotyp0.93247421
65MP0001545_abnormal_hematopoietic_system0.93247421
66MP0003861_abnormal_nervous_system0.93199913
67MP0002234_abnormal_pharynx_morphology0.91415631
68MP0000647_abnormal_sebaceous_gland0.90063283
69MP0008789_abnormal_olfactory_epithelium0.89382127
70MP0001119_abnormal_female_reproductive0.89230538
71MP0005389_reproductive_system_phenotype0.87903105
72MP0004133_heterotaxia0.87869227
73MP0003937_abnormal_limbs/digits/tail_de0.86469078
74MP0000703_abnormal_thymus_morphology0.86252061
75MP0002095_abnormal_skin_pigmentation0.85069165
76MP0000428_abnormal_craniofacial_morphol0.83785078
77MP0002398_abnormal_bone_marrow0.83333795
78MP0002249_abnormal_larynx_morphology0.82847809
79MP0001188_hyperpigmentation0.81412765
80MP0002722_abnormal_immune_system0.81016690
81MP0002163_abnormal_gland_morphology0.80686734
82MP0003755_abnormal_palate_morphology0.80321421
83MP0001286_abnormal_eye_development0.79095862
84MP0005187_abnormal_penis_morphology0.77479961
85MP0000579_abnormal_nail_morphology0.77344906
86MP0003119_abnormal_digestive_system0.77329723
87MP0005394_taste/olfaction_phenotype0.77202967
88MP0005499_abnormal_olfactory_system0.77202967
89MP0003763_abnormal_thymus_physiology0.77101308
90MP0004381_abnormal_hair_follicle0.75206285
91MP0006036_abnormal_mitochondrial_physio0.74755697
92MP0000689_abnormal_spleen_morphology0.73643721
93MP0002111_abnormal_tail_morphology0.73172581
94MP0009053_abnormal_anal_canal0.72013728
95MP0001919_abnormal_reproductive_system0.71602645
96MP0002653_abnormal_ependyma_morphology0.71435694
97MP0000358_abnormal_cell_content/0.70975222
98MP0000049_abnormal_middle_ear0.70744881
99MP0000372_irregular_coat_pigmentation0.70724342
100MP0005391_vision/eye_phenotype0.70409565
101MP0008995_early_reproductive_senescence0.70349191
102MP0005075_abnormal_melanosome_morpholog0.69070078
103MP0002429_abnormal_blood_cell0.68731379
104MP0001299_abnormal_eye_distance/0.68039612
105MP0000631_abnormal_neuroendocrine_gland0.67795815
106MP0005408_hypopigmentation0.66938546
107MP0000432_abnormal_head_morphology0.66729834
108MP0003935_abnormal_craniofacial_develop0.66396173
109MP0006035_abnormal_mitochondrial_morpho0.66367713
110MP0000537_abnormal_urethra_morphology0.65972026
111MP0009697_abnormal_copulation0.65881808
112MP0002161_abnormal_fertility/fecundity0.64784831
113MP0004233_abnormal_muscle_weight0.63761497
114MP0000858_altered_metastatic_potential0.63538401
115MP0002751_abnormal_autonomic_nervous0.62434233
116MP0004147_increased_porphyrin_level0.61163608
117MP0003699_abnormal_female_reproductive0.60834209
118MP0002092_abnormal_eye_morphology0.60732093
119MP0001661_extended_life_span0.60412432
120MP0008260_abnormal_autophagy0.59320645
121MP0005174_abnormal_tail_pigmentation0.58955109
122MP0003385_abnormal_body_wall0.58544978
123MP0005384_cellular_phenotype0.58009127
124MP0004185_abnormal_adipocyte_glucose0.57795054
125MP0001186_pigmentation_phenotype0.57508217
126MP0005395_other_phenotype0.56796958
127MP0001727_abnormal_embryo_implantation0.55658812
128MP0005501_abnormal_skin_physiology0.55393768
129MP0003698_abnormal_male_reproductive0.54941140
130MP0009672_abnormal_birth_weight0.52702507
131MP0002277_abnormal_respiratory_mucosa0.52638281

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.58769784
2Abnormality of cells of the erythroid lineage (HP:0012130)5.35102450
3Birth length less than 3rd percentile (HP:0003561)5.22176633
4Abnormal number of erythroid precursors (HP:0012131)4.87379351
5Breast hypoplasia (HP:0003187)4.37864629
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.28077902
7Chromsome breakage (HP:0040012)4.26515258
8Macrocytic anemia (HP:0001972)3.73932212
9Patellar aplasia (HP:0006443)3.51837279
10Abnormality of the preputium (HP:0100587)3.49440174
11Pallor (HP:0000980)3.49128729
12Meckel diverticulum (HP:0002245)3.45202882
13Oral leukoplakia (HP:0002745)3.31032767
14Abnormality of the ileum (HP:0001549)3.30244738
15Aplasia/Hypoplasia of the patella (HP:0006498)3.30241357
16Abnormality of chromosome stability (HP:0003220)3.27387055
17Absent thumb (HP:0009777)3.20674779
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.12671479
19Colon cancer (HP:0003003)3.10217430
20Absent radius (HP:0003974)3.08712340
21Carpal bone hypoplasia (HP:0001498)3.02201577
22Aplastic anemia (HP:0001915)2.93977683
23Absent forearm bone (HP:0003953)2.89535700
24Aplasia involving forearm bones (HP:0009822)2.89535700
25Triphalangeal thumb (HP:0001199)2.83547068
26Medulloblastoma (HP:0002885)2.81113947
27Degeneration of anterior horn cells (HP:0002398)2.80226494
28Abnormality of the anterior horn cell (HP:0006802)2.80226494
29Impulsivity (HP:0100710)2.80090924
30Rough bone trabeculation (HP:0100670)2.79713935
31Small intestinal stenosis (HP:0012848)2.77703294
32Duodenal stenosis (HP:0100867)2.77703294
33Selective tooth agenesis (HP:0001592)2.73133736
34Increased nuchal translucency (HP:0010880)2.68935139
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68023748
3611 pairs of ribs (HP:0000878)2.63607244
37Duplicated collecting system (HP:0000081)2.63293319
38Cortical dysplasia (HP:0002539)2.60800435
39Cerebral hypomyelination (HP:0006808)2.56471279
40Bone marrow hypocellularity (HP:0005528)2.50002951
41Myelodysplasia (HP:0002863)2.49453757
42Hypoplasia of the radius (HP:0002984)2.44562368
43Agnosia (HP:0010524)2.42704178
44Premature graying of hair (HP:0002216)2.41612952
45Abnormal number of incisors (HP:0011064)2.40473376
46Cleft eyelid (HP:0000625)2.38725860
47Atresia of the external auditory canal (HP:0000413)2.38106718
48Horseshoe kidney (HP:0000085)2.36676102
49Trismus (HP:0000211)2.36285677
50Abnormal lung lobation (HP:0002101)2.35727366
51Tracheoesophageal fistula (HP:0002575)2.28834073
52Glioma (HP:0009733)2.28050858
53Sloping forehead (HP:0000340)2.27506313
54Abnormality of the duodenum (HP:0002246)2.26375650
55Neoplasm of the pancreas (HP:0002894)2.25052571
56Short thumb (HP:0009778)2.22903031
57Abnormality of the renal collecting system (HP:0004742)2.21628811
58Secondary amenorrhea (HP:0000869)2.20302844
59Multiple enchondromatosis (HP:0005701)2.19623139
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18986411
61Volvulus (HP:0002580)2.16052245
62Microretrognathia (HP:0000308)2.14953824
63Premature ovarian failure (HP:0008209)2.14527080
64Microvesicular hepatic steatosis (HP:0001414)2.13517543
65Abnormality of reticulocytes (HP:0004312)2.12056823
66Septo-optic dysplasia (HP:0100842)2.11668788
67Increased hepatocellular lipid droplets (HP:0006565)2.06012643
68Ependymoma (HP:0002888)2.05532376
69Ectopic kidney (HP:0000086)2.05327290
70Clubbing of toes (HP:0100760)2.05269533
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04746967
72Abnormality of cochlea (HP:0000375)2.04720450
73Pancytopenia (HP:0001876)2.03759810
74Rhabdomyosarcoma (HP:0002859)2.03647958
75Cellular immunodeficiency (HP:0005374)2.03217076
76Abnormality of the carotid arteries (HP:0005344)2.02821283
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01475312
78Sparse eyelashes (HP:0000653)2.00572087
79Stenosis of the external auditory canal (HP:0000402)1.99801743
80Supernumerary spleens (HP:0009799)1.97960476
81Cafe-au-lait spot (HP:0000957)1.97675433
82Duplication of thumb phalanx (HP:0009942)1.97628552
83Abnormality of the labia minora (HP:0012880)1.96822018
84Abnormal trabecular bone morphology (HP:0100671)1.96195227
85Abnormality of pyrimidine metabolism (HP:0004353)1.96185386
86High anterior hairline (HP:0009890)1.95797474
87Hypoplastic pelvis (HP:0008839)1.94699411
88Embryonal neoplasm (HP:0002898)1.92437786
89Abnormality of the astrocytes (HP:0100707)1.91763054
90Astrocytoma (HP:0009592)1.91763054
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91730376
92Abnormality of the heme biosynthetic pathway (HP:0010472)1.90425030
93Bilateral microphthalmos (HP:0007633)1.90420915
94Nephroblastoma (Wilms tumor) (HP:0002667)1.89908159
95Facial cleft (HP:0002006)1.88716416
96Choanal atresia (HP:0000453)1.88675346
97Hyperglycinemia (HP:0002154)1.86977150
98Pancreatic islet-cell hyperplasia (HP:0004510)1.86598460
99Hypoplasia of the pons (HP:0012110)1.85242443
100Exertional dyspnea (HP:0002875)1.85118104
101Abnormality of DNA repair (HP:0003254)1.85107915
102Progressive muscle weakness (HP:0003323)1.84002685
103Abnormality of methionine metabolism (HP:0010901)1.83861427
104Aplasia/Hypoplasia of the earlobes (HP:0009906)1.83417315
105Increased serum lactate (HP:0002151)1.83337646
106Abnormal umbilical cord blood vessels (HP:0011403)1.82340841
107Single umbilical artery (HP:0001195)1.82340841
108Abnormality of the fetal cardiovascular system (HP:0010948)1.82340841
1093-Methylglutaconic aciduria (HP:0003535)1.80461037
110Abnormality of serum amino acid levels (HP:0003112)1.79945518
111Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79939496
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79939496
113Ureteral duplication (HP:0000073)1.79888145
114Arteriovenous malformation (HP:0100026)1.79464937
115Type I transferrin isoform profile (HP:0003642)1.78899077
116Pendular nystagmus (HP:0012043)1.77896609
117Depressed nasal ridge (HP:0000457)1.76622316
118Neoplasm of the adrenal cortex (HP:0100641)1.76286034
119Embryonal renal neoplasm (HP:0011794)1.71291078
120Abnormality of the pons (HP:0007361)1.71258179
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.71151830
122Neoplasm of the colon (HP:0100273)1.70797598
123Acute encephalopathy (HP:0006846)1.70763079
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.70559931
125Lymphoma (HP:0002665)1.69677122
126Irregular epiphyses (HP:0010582)1.69673258
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69502660
128Abnormality of alanine metabolism (HP:0010916)1.69502660
129Hyperalaninemia (HP:0003348)1.69502660
130Partial duplication of thumb phalanx (HP:0009944)1.69498370
131Abnormality of the septum pellucidum (HP:0007375)1.66958854
132Morphological abnormality of the inner ear (HP:0011390)1.66171999
133Abnormality of homocysteine metabolism (HP:0010919)1.66112677
134Homocystinuria (HP:0002156)1.66112677
135Absent septum pellucidum (HP:0001331)1.65831805
136Spastic diplegia (HP:0001264)1.65528469
137Hyperglycinuria (HP:0003108)1.63922018
138High pitched voice (HP:0001620)1.61816237
139Neoplasm of the adrenal gland (HP:0100631)1.61194568
140Abnormality of glycolysis (HP:0004366)1.61054258
141Megaloblastic anemia (HP:0001889)1.60855692
142Lipid accumulation in hepatocytes (HP:0006561)1.58615924
143Preaxial hand polydactyly (HP:0001177)1.58286041
144Abnormality of glycine metabolism (HP:0010895)1.57713241
145Abnormality of serine family amino acid metabolism (HP:0010894)1.57713241
146Bifid tongue (HP:0010297)1.57511607
147Acute necrotizing encephalopathy (HP:0006965)1.57404850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.49995157
2WEE14.61776100
3CDC74.10342025
4VRK23.27163081
5STK163.24845279
6EIF2AK13.20095006
7NME23.03516014
8SRPK12.80042429
9TTK2.62393214
10NEK22.55799227
11BRSK22.54862675
12TAF12.50548330
13TLK12.37776625
14PLK42.25866246
15VRK12.19119593
16PLK12.12322741
17EIF2AK32.03959147
18ACVR1B1.95738941
19ZAK1.91541315
20MKNK11.91371096
21DYRK31.83931759
22AURKB1.77016554
23NEK11.73045060
24CHEK21.72359892
25PLK31.69940678
26BRSK11.67607636
27ATR1.63204475
28CDK71.60040286
29TRIM281.52336686
30TSSK61.49206352
31NUAK11.48968579
32CCNB11.42455187
33AURKA1.41769512
34MKNK21.41167889
35TESK21.39229636
36PASK1.32409703
37RPS6KA41.21030299
38SMG11.20396168
39RPS6KB21.19361493
40CDK41.17163430
41MAP3K81.14109902
42STK41.12871741
43CHEK11.10256870
44WNK31.07678490
45CDK81.03308216
46BMPR1B0.98233210
47PIM20.95880954
48EIF2AK20.93304897
49BRAF0.92207515
50PBK0.90636820
51EPHA20.87807258
52TGFBR10.87762828
53SCYL20.82764338
54CDK120.81788875
55TNIK0.81553596
56CSNK2A10.80333243
57STK100.78321999
58ATM0.76448346
59CDK20.75131168
60MST40.75112203
61PIM10.74784250
62CSNK2A20.74057104
63PAK40.72459740
64ERBB40.68954969
65NME10.68881214
66DYRK20.66891210
67CLK10.66149320
68BRD40.64456734
69MAP3K110.62239522
70PNCK0.61742402
71PAK10.61486381
72EEF2K0.60097670
73CDK10.58960580
74BCR0.58891381
75FGFR10.57734210
76RPS6KA50.57182288
77CSNK1A1L0.53901373
78LRRK20.53508528
79TESK10.50755355
80ERBB30.49430766
81MAP4K10.48467294
82CSNK1G20.47621361
83KDR0.46779419
84ABL20.45828422
85CDK60.45046583
86LATS10.44960153
87PRKCI0.44777860
88LIMK10.44559560
89PDK20.43707203
90MELK0.42919503
91CDK190.41661481
92PLK20.40470053
93IRAK40.35696412
94CDK90.34606068
95STK30.33645228
96INSRR0.33531226
97MAP3K40.32563898
98BCKDK0.32322673
99MAP4K20.31415113
100ILK0.31105254
101FLT30.30908962
102DAPK10.30762005
103CDK140.30585673
104WNK40.28877609
105AKT20.28183419
106CSNK1E0.27663172
107MAP2K70.27201435
108MAP3K100.27199668
109CAMK1G0.27048281
110STK390.26997236
111BTK0.26842166
112ALK0.26227377
113IRAK30.25031268
114PRKDC0.24149050
115TEC0.23932907
116MAP2K30.23229045
117STK38L0.22220648
118YES10.21432603
119CDK11A0.20309424
120CSNK1G30.19698657
121LYN0.18717506
122MAPKAPK20.17768664
123CDK30.16770309
124BLK0.14815978
125MAPK140.14417016
126CSNK1D0.14405263
127AKT10.14337915
128CDK150.13452137
129CDK180.12607302
130AKT30.10288604
131CSNK1G10.10179645

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.26314094
2Ribosome_Homo sapiens_hsa030104.53906940
3Mismatch repair_Homo sapiens_hsa034304.41104448
4Proteasome_Homo sapiens_hsa030503.57715769
5RNA polymerase_Homo sapiens_hsa030203.55004949
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34327375
7Homologous recombination_Homo sapiens_hsa034403.25106757
8Spliceosome_Homo sapiens_hsa030403.20955643
9Nucleotide excision repair_Homo sapiens_hsa034203.05307799
10Base excision repair_Homo sapiens_hsa034102.99914288
11RNA transport_Homo sapiens_hsa030132.86125447
12Pyrimidine metabolism_Homo sapiens_hsa002402.75507995
13Cell cycle_Homo sapiens_hsa041102.68517428
14Fanconi anemia pathway_Homo sapiens_hsa034602.59208271
15One carbon pool by folate_Homo sapiens_hsa006702.19174737
16Basal transcription factors_Homo sapiens_hsa030222.06433929
17Non-homologous end-joining_Homo sapiens_hsa034501.94321182
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86036522
19RNA degradation_Homo sapiens_hsa030181.71985575
20p53 signaling pathway_Homo sapiens_hsa041151.61928973
21Vitamin B6 metabolism_Homo sapiens_hsa007501.51309343
22mRNA surveillance pathway_Homo sapiens_hsa030151.47546970
23Purine metabolism_Homo sapiens_hsa002301.47289391
24Systemic lupus erythematosus_Homo sapiens_hsa053221.34547850
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30269489
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29903480
27Pyruvate metabolism_Homo sapiens_hsa006201.23065199
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19752039
29Steroid biosynthesis_Homo sapiens_hsa001001.15687461
30Huntingtons disease_Homo sapiens_hsa050161.11269981
31Propanoate metabolism_Homo sapiens_hsa006401.07979542
32Epstein-Barr virus infection_Homo sapiens_hsa051691.03671153
33Parkinsons disease_Homo sapiens_hsa050121.02800330
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01552043
35Protein export_Homo sapiens_hsa030601.00157945
36Oxidative phosphorylation_Homo sapiens_hsa001900.93504495
37Folate biosynthesis_Homo sapiens_hsa007900.89775968
38Fatty acid elongation_Homo sapiens_hsa000620.88354116
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.86477665
40Oocyte meiosis_Homo sapiens_hsa041140.83955952
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83617071
42Lysine degradation_Homo sapiens_hsa003100.83486199
43Sulfur relay system_Homo sapiens_hsa041220.79621329
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75178245
45Pentose phosphate pathway_Homo sapiens_hsa000300.74528176
46Herpes simplex infection_Homo sapiens_hsa051680.73229763
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72206607
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71189016
49Viral carcinogenesis_Homo sapiens_hsa052030.71003104
50Glutathione metabolism_Homo sapiens_hsa004800.70097073
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.68294635
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.66718884
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65211171
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63766212
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62483073
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62064237
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57224963
58HTLV-I infection_Homo sapiens_hsa051660.55966051
59Antigen processing and presentation_Homo sapiens_hsa046120.55026807
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54713483
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52357813
62Biosynthesis of amino acids_Homo sapiens_hsa012300.50940602
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49992564
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47981370
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47282153
66Selenocompound metabolism_Homo sapiens_hsa004500.46800734
67Alzheimers disease_Homo sapiens_hsa050100.46058815
68Wnt signaling pathway_Homo sapiens_hsa043100.45726341
69Alcoholism_Homo sapiens_hsa050340.45550744
70Fatty acid metabolism_Homo sapiens_hsa012120.45223198
71Basal cell carcinoma_Homo sapiens_hsa052170.44349853
72Arachidonic acid metabolism_Homo sapiens_hsa005900.42219818
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38737943
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38252536
75Butanoate metabolism_Homo sapiens_hsa006500.38022245
76Metabolic pathways_Homo sapiens_hsa011000.37429627
77Primary immunodeficiency_Homo sapiens_hsa053400.35371160
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35112630
79MicroRNAs in cancer_Homo sapiens_hsa052060.34220154
80Carbon metabolism_Homo sapiens_hsa012000.29674396
81Small cell lung cancer_Homo sapiens_hsa052220.29443682
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29262421
83Hedgehog signaling pathway_Homo sapiens_hsa043400.29191890
84Adherens junction_Homo sapiens_hsa045200.28439803
85Legionellosis_Homo sapiens_hsa051340.27841995
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27359297
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26979548
88Apoptosis_Homo sapiens_hsa042100.26552246
89Thyroid cancer_Homo sapiens_hsa052160.26476767
90Linoleic acid metabolism_Homo sapiens_hsa005910.26322260
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.26101050
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24290559
93Notch signaling pathway_Homo sapiens_hsa043300.24019803
94N-Glycan biosynthesis_Homo sapiens_hsa005100.23855243
95Phototransduction_Homo sapiens_hsa047440.23459470
96Hippo signaling pathway_Homo sapiens_hsa043900.22960658
97Renin-angiotensin system_Homo sapiens_hsa046140.22798412
98TGF-beta signaling pathway_Homo sapiens_hsa043500.21201322
99Tight junction_Homo sapiens_hsa045300.21055520
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19529441
101Colorectal cancer_Homo sapiens_hsa052100.19433779
102Fructose and mannose metabolism_Homo sapiens_hsa000510.18551073
103Melanoma_Homo sapiens_hsa052180.17678547
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17579287
105Asthma_Homo sapiens_hsa053100.16737438
106Arginine and proline metabolism_Homo sapiens_hsa003300.16525137
107Prostate cancer_Homo sapiens_hsa052150.16343346
108Bladder cancer_Homo sapiens_hsa052190.16318388
109Regulation of autophagy_Homo sapiens_hsa041400.15317848
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.14629504
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.14150738
112Peroxisome_Homo sapiens_hsa041460.13451623
113Hematopoietic cell lineage_Homo sapiens_hsa046400.13065183
114Allograft rejection_Homo sapiens_hsa053300.11646110
115Hepatitis B_Homo sapiens_hsa051610.11150435
116Measles_Homo sapiens_hsa051620.10802965
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10480375
118Pathways in cancer_Homo sapiens_hsa052000.10149190
119Arginine biosynthesis_Homo sapiens_hsa002200.09266550
120beta-Alanine metabolism_Homo sapiens_hsa004100.09189755
121Nitrogen metabolism_Homo sapiens_hsa009100.08170137
122Galactose metabolism_Homo sapiens_hsa000520.06254746
123Autoimmune thyroid disease_Homo sapiens_hsa053200.06202625
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.06020119
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04446749
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04155959
127Shigellosis_Homo sapiens_hsa051310.04060126
128Cardiac muscle contraction_Homo sapiens_hsa042600.01397837
129Vitamin digestion and absorption_Homo sapiens_hsa049770.01197910

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