GINS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)5.24243259
2DNA strand elongation involved in DNA replication (GO:0006271)5.24198635
3DNA replication checkpoint (GO:0000076)5.05558342
4DNA strand elongation (GO:0022616)4.95208410
5telomere maintenance via semi-conservative replication (GO:0032201)4.92158822
6DNA unwinding involved in DNA replication (GO:0006268)4.78539535
7negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.72609031
8telomere maintenance via recombination (GO:0000722)4.43692403
9ribosomal small subunit assembly (GO:0000028)4.41844708
10protein localization to kinetochore (GO:0034501)4.35668125
11mitotic metaphase plate congression (GO:0007080)4.29015821
12mitotic recombination (GO:0006312)4.24663443
13regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.24026334
14CENP-A containing nucleosome assembly (GO:0034080)4.21424120
15regulation of retinoic acid receptor signaling pathway (GO:0048385)4.18842382
16ribosome assembly (GO:0042255)4.14212394
17chromatin remodeling at centromere (GO:0031055)4.09608803
18maturation of SSU-rRNA (GO:0030490)4.07091795
19nucleobase biosynthetic process (GO:0046112)4.06507588
20purine nucleobase biosynthetic process (GO:0009113)3.97686054
21telomere maintenance via telomere lengthening (GO:0010833)3.91046457
22kinetochore organization (GO:0051383)3.84793602
23pseudouridine synthesis (GO:0001522)3.82322709
24replication fork processing (GO:0031297)3.82144013
25DNA replication-independent nucleosome organization (GO:0034724)3.81816419
26DNA replication-independent nucleosome assembly (GO:0006336)3.81816419
27protein localization to chromosome, centromeric region (GO:0071459)3.81180038
28mitotic nuclear envelope disassembly (GO:0007077)3.80668748
29formation of translation preinitiation complex (GO:0001731)3.77696142
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.74171833
31metaphase plate congression (GO:0051310)3.69259820
32DNA replication-dependent nucleosome assembly (GO:0006335)3.68118078
33DNA replication-dependent nucleosome organization (GO:0034723)3.68118078
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65116544
35attachment of spindle microtubules to kinetochore (GO:0008608)3.55132758
36viral transcription (GO:0019083)3.54594930
37nuclear envelope disassembly (GO:0051081)3.54236095
38membrane disassembly (GO:0030397)3.54236095
39translational termination (GO:0006415)3.54170876
40kinetochore assembly (GO:0051382)3.51285762
41mitotic chromosome condensation (GO:0007076)3.50995652
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.49642333
43histone exchange (GO:0043486)3.45336752
44establishment of chromosome localization (GO:0051303)3.44408609
45IMP biosynthetic process (GO:0006188)3.40052713
46folic acid-containing compound biosynthetic process (GO:0009396)3.34521262
47regulation of mitochondrial translation (GO:0070129)3.33683969
48ribosome biogenesis (GO:0042254)3.32057472
49ribosomal large subunit biogenesis (GO:0042273)3.31876573
50nuclear pore organization (GO:0006999)3.31339614
51rRNA modification (GO:0000154)3.29186802
52respiratory chain complex IV assembly (GO:0008535)3.28555466
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.28219240
54mitotic sister chromatid segregation (GO:0000070)3.27553557
55DNA double-strand break processing (GO:0000729)3.27459912
56termination of RNA polymerase III transcription (GO:0006386)3.26912199
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.26912199
58regulation of spindle organization (GO:0090224)3.26390228
59translational initiation (GO:0006413)3.26067152
60mitochondrial RNA metabolic process (GO:0000959)3.24548657
61translational elongation (GO:0006414)3.22690539
62ribonucleoprotein complex biogenesis (GO:0022613)3.20703199
63chaperone-mediated protein transport (GO:0072321)3.19599108
64negative regulation of DNA-dependent DNA replication (GO:2000104)3.17505027
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17092472
66regulation of double-strand break repair via homologous recombination (GO:0010569)3.15078247
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14818585
68nuclear pore complex assembly (GO:0051292)3.14672571
69DNA deamination (GO:0045006)3.14588477
70recombinational repair (GO:0000725)3.14324121
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14172542
72double-strand break repair via homologous recombination (GO:0000724)3.12831785
73spliceosomal snRNP assembly (GO:0000387)3.12012197
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.11279998
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10890648
76regulation of mitotic spindle checkpoint (GO:1903504)3.10890648
77maturation of 5.8S rRNA (GO:0000460)3.10255958
78spindle checkpoint (GO:0031577)3.10194772
79cell cycle G1/S phase transition (GO:0044843)3.09213847
80G1/S transition of mitotic cell cycle (GO:0000082)3.09213847
81resolution of meiotic recombination intermediates (GO:0000712)3.08621883
82meiotic chromosome segregation (GO:0045132)3.07152729
83ATP-dependent chromatin remodeling (GO:0043044)3.05835499
84sister chromatid segregation (GO:0000819)3.05652356
85DNA geometric change (GO:0032392)3.05560137
86regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04646584
87proteasome assembly (GO:0043248)3.04570082
88transcription from mitochondrial promoter (GO:0006390)3.04456133
89DNA duplex unwinding (GO:0032508)3.03986130
90chromatin assembly or disassembly (GO:0006333)3.03254014
91telomere maintenance (GO:0000723)3.03178336
92translesion synthesis (GO:0019985)3.03011584
93telomere organization (GO:0032200)3.02128410
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.02060943
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02060943
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02060943
97negative regulation of sister chromatid segregation (GO:0033046)3.02060943
98negative regulation of chromosome segregation (GO:0051985)3.01918034
99spindle assembly checkpoint (GO:0071173)3.01737784
100centriole replication (GO:0007099)3.01614869
101mitochondrial respiratory chain complex assembly (GO:0033108)3.00997293
102ribosomal small subunit biogenesis (GO:0042274)3.00707254
103base-excision repair, AP site formation (GO:0006285)3.00237718
104rRNA processing (GO:0006364)2.99882798
105synapsis (GO:0007129)2.99717789
106transcription-coupled nucleotide-excision repair (GO:0006283)2.99413963
107mismatch repair (GO:0006298)2.98914233
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97799593
109mitotic spindle assembly checkpoint (GO:0007094)2.97591978
110protein complex biogenesis (GO:0070271)2.97059140
111IMP metabolic process (GO:0046040)2.96971413
112protein K6-linked ubiquitination (GO:0085020)2.96124514
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96046513
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95531979
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93459892
116regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93406422
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.92565028
118NADH dehydrogenase complex assembly (GO:0010257)2.92565028
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92565028
120postreplication repair (GO:0006301)2.92496175
121regulation of chromosome segregation (GO:0051983)2.91656256
122rRNA metabolic process (GO:0016072)2.90784917
123male meiosis I (GO:0007141)2.90166572
124regulation of DNA endoreduplication (GO:0032875)2.90081568
125mitotic spindle checkpoint (GO:0071174)2.89333425
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89105627
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88955601
128folic acid metabolic process (GO:0046655)2.87754136
129nuclear envelope organization (GO:0006998)2.87669441
130protein localization to chromosome (GO:0034502)2.87651805
131reciprocal DNA recombination (GO:0035825)2.87612220
132reciprocal meiotic recombination (GO:0007131)2.87612220
133regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87298826
134spliceosomal complex assembly (GO:0000245)2.86912914
135DNA catabolic process, exonucleolytic (GO:0000738)2.86869376
136cotranslational protein targeting to membrane (GO:0006613)2.86049212
137cytochrome complex assembly (GO:0017004)2.85839092
138protein targeting to ER (GO:0045047)2.84915055
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.83304167
140piRNA metabolic process (GO:0034587)2.82172846
141tRNA processing (GO:0008033)2.80092018
142rRNA methylation (GO:0031167)2.79698826
143L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79183553
144peptidyl-histidine modification (GO:0018202)2.78724051
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77403537
146DNA strand renaturation (GO:0000733)2.74402670
147regulation of centrosome cycle (GO:0046605)2.72071950
148DNA recombination (GO:0006310)2.71663447
149mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.71521490
150regulation of centriole replication (GO:0046599)2.68520069
151protein-cofactor linkage (GO:0018065)2.68142008
152meiosis I (GO:0007127)2.67818068
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66656500
154isotype switching (GO:0045190)2.66656500
155somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66656500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.43767401
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16075123
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.12540686
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87299249
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58675894
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18217355
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17803125
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88158868
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.80854606
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70377800
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.65625450
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62902447
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62854607
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60930667
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.60468403
16ZNF274_21170338_ChIP-Seq_K562_Hela2.49423229
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30329251
18* E2F1_21310950_ChIP-Seq_MCF-7_Human2.27809164
19XRN2_22483619_ChIP-Seq_HELA_Human2.26513757
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25963122
21VDR_23849224_ChIP-Seq_CD4+_Human2.25045833
22AR_21909140_ChIP-Seq_LNCAP_Human2.14621618
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.08667910
24* FOXP3_21729870_ChIP-Seq_TREG_Human1.99041098
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98013647
26DCP1A_22483619_ChIP-Seq_HELA_Human1.97323031
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94612594
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92810745
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89019469
30VDR_22108803_ChIP-Seq_LS180_Human1.87393640
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86953681
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82587002
33GABP_19822575_ChIP-Seq_HepG2_Human1.79769440
34CIITA_25753668_ChIP-Seq_RAJI_Human1.79581652
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76620101
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72301915
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71805431
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68658487
39* ELK1_19687146_ChIP-ChIP_HELA_Human1.68549159
40TTF2_22483619_ChIP-Seq_HELA_Human1.68400375
41EWS_26573619_Chip-Seq_HEK293_Human1.68239200
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66762529
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66114438
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65796624
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.65472099
46* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64882780
47* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64470441
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63812993
49IGF1R_20145208_ChIP-Seq_DFB_Human1.63505430
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60257224
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58435095
52* MYC_22102868_ChIP-Seq_BL_Human1.57147064
53IRF1_19129219_ChIP-ChIP_H3396_Human1.56426285
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53625129
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52448389
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48291354
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.46827277
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43023334
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42886915
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42029578
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40459939
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39864645
63* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36973832
64KDM5A_27292631_Chip-Seq_BREAST_Human1.36671135
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33944553
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.33315709
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32638532
68FUS_26573619_Chip-Seq_HEK293_Human1.27739456
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27198251
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25744011
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25334743
72* SRF_21415370_ChIP-Seq_HL-1_Mouse1.23957410
73TP53_22573176_ChIP-Seq_HFKS_Human1.21962558
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21682720
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20861257
76TFEB_21752829_ChIP-Seq_HELA_Human1.20778442
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13963498
78SPI1_23547873_ChIP-Seq_NB4_Human1.12265126
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.11637502
80VDR_21846776_ChIP-Seq_THP-1_Human1.10347931
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09436008
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07254203
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05258369
84* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04357972
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04320897
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02883718
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02215593
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01960801
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00906178
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00878231
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00780174
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00031511
93MYC_18940864_ChIP-ChIP_HL60_Human0.99702755
94* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99095328
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.99059120
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98959464
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.97568648
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96463485
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95815134
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94236730
101POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93929043
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92550045
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92353448
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92263514
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90741798
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90658556
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89790030
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.87807354
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87325811
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.85743419
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85190223
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84930766
113GBX2_23144817_ChIP-Seq_PC3_Human0.84716119
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83703452
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83691815
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83219970
117P300_19829295_ChIP-Seq_ESCs_Human0.78805109
118NANOG_16153702_ChIP-ChIP_HESCs_Human0.77644467
119* MYB_26560356_Chip-Seq_TH1_Human0.77513149
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76406009
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.75874214
122NCOR_22424771_ChIP-Seq_293T_Human0.75239924
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75169436
124MYB_26560356_Chip-Seq_TH2_Human0.74800078
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70837307
126NANOG_19829295_ChIP-Seq_ESCs_Human0.70440606
127SOX2_19829295_ChIP-Seq_ESCs_Human0.70440606
128AR_20517297_ChIP-Seq_VCAP_Human0.69744947
129FOXA1_25329375_ChIP-Seq_VCAP_Human0.68017547
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.68017547
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67829789
132TAF15_26573619_Chip-Seq_HEK293_Human0.67389518
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66161816
134HOXB7_26014856_ChIP-Seq_BT474_Human0.66149278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.14949791
2MP0008057_abnormal_DNA_replication4.93362131
3MP0010094_abnormal_chromosome_stability4.82835856
4MP0004957_abnormal_blastocyst_morpholog4.34074936
5MP0003111_abnormal_nucleus_morphology4.30841987
6MP0003077_abnormal_cell_cycle4.08347005
7MP0008007_abnormal_cellular_replicative3.17913210
8MP0008058_abnormal_DNA_repair3.08171677
9MP0002396_abnormal_hematopoietic_system2.99420178
10MP0008932_abnormal_embryonic_tissue2.56217486
11MP0003123_paternal_imprinting2.24873302
12MP0001730_embryonic_growth_arrest2.23908496
13MP0000350_abnormal_cell_proliferation2.19830284
14MP0000372_irregular_coat_pigmentation2.07106802
15MP0003646_muscle_fatigue2.02350999
16MP0010307_abnormal_tumor_latency2.01420372
17MP0004808_abnormal_hematopoietic_stem1.88242654
18MP0000490_abnormal_crypts_of1.86224902
19MP0006072_abnormal_retinal_apoptosis1.76259017
20MP0003136_yellow_coat_color1.71686417
21MP0010352_gastrointestinal_tract_polyps1.71262178
22MP0003786_premature_aging1.67487810
23MP0001697_abnormal_embryo_size1.66051556
24MP0001986_abnormal_taste_sensitivity1.65963611
25MP0003315_abnormal_perineum_morphology1.64686551
26MP0005380_embryogenesis_phenotype1.63374571
27MP0001672_abnormal_embryogenesis/_devel1.63374571
28MP0008877_abnormal_DNA_methylation1.62643973
29MP0002837_dystrophic_cardiac_calcinosis1.59706304
30MP0009333_abnormal_splenocyte_physiolog1.54806370
31MP0003718_maternal_effect1.53827692
32MP0002938_white_spotting1.53490954
33MP0002398_abnormal_bone_marrow1.52899003
34MP0002019_abnormal_tumor_incidence1.52862907
35MP0001529_abnormal_vocalization1.49313812
36MP0002080_prenatal_lethality1.49274194
37MP0009697_abnormal_copulation1.47200901
38MP0003984_embryonic_growth_retardation1.47035887
39MP0000313_abnormal_cell_death1.45601911
40MP0005551_abnormal_eye_electrophysiolog1.45328613
41MP0002088_abnormal_embryonic_growth/wei1.44036952
42MP0003763_abnormal_thymus_physiology1.43169079
43MP0000703_abnormal_thymus_morphology1.39522105
44MP0008789_abnormal_olfactory_epithelium1.39227175
45MP0002722_abnormal_immune_system1.38773017
46MP0005379_endocrine/exocrine_gland_phen1.38434776
47MP0006035_abnormal_mitochondrial_morpho1.37095819
48MP0000015_abnormal_ear_pigmentation1.35793058
49MP0001545_abnormal_hematopoietic_system1.35517340
50MP0005397_hematopoietic_system_phenotyp1.35517340
51MP0002085_abnormal_embryonic_tissue1.34056120
52MP0000689_abnormal_spleen_morphology1.34037871
53MP0003567_abnormal_fetal_cardiomyocyte1.33258321
54MP0000631_abnormal_neuroendocrine_gland1.32691928
55MP0002086_abnormal_extraembryonic_tissu1.32654240
56MP0002234_abnormal_pharynx_morphology1.30321532
57MP0002736_abnormal_nociception_after1.29130959
58MP0005253_abnormal_eye_physiology1.28734559
59MP0005646_abnormal_pituitary_gland1.26143336
60MP0001835_abnormal_antigen_presentation1.25720358
61MP0002084_abnormal_developmental_patter1.24702433
62MP0009046_muscle_twitch1.24387479
63MP0000569_abnormal_digit_pigmentation1.21922928
64MP0006036_abnormal_mitochondrial_physio1.21522640
65MP0000049_abnormal_middle_ear1.20069237
66MP0004197_abnormal_fetal_growth/weight/1.18190333
67MP0002429_abnormal_blood_cell1.18033550
68MP0001968_abnormal_touch/_nociception1.16802629
69MP0003698_abnormal_male_reproductive1.13385510
70MP0008995_early_reproductive_senescence1.11948016
71MP0000716_abnormal_immune_system1.11599391
72MP0003221_abnormal_cardiomyocyte_apopto1.11172128
73MP0004147_increased_porphyrin_level1.10228002
74MP0005645_abnormal_hypothalamus_physiol1.09363995
75MP0002638_abnormal_pupillary_reflex1.08990700
76MP0000427_abnormal_hair_cycle1.07582783
77MP0001346_abnormal_lacrimal_gland1.06667304
78MP0002210_abnormal_sex_determination1.06587456
79MP0005395_other_phenotype1.06306927
80MP0001800_abnormal_humoral_immune1.04611024
81MP0001188_hyperpigmentation1.02285959
82MP0006054_spinal_hemorrhage1.01593181
83MP0003121_genomic_imprinting1.01043134
84MP0002420_abnormal_adaptive_immunity0.99559307
85MP0001819_abnormal_immune_cell0.98839332
86MP0000537_abnormal_urethra_morphology0.97934660
87MP0002452_abnormal_antigen_presenting0.97707308
88MP0005499_abnormal_olfactory_system0.97277745
89MP0005394_taste/olfaction_phenotype0.97277745
90MP0001293_anophthalmia0.96397419
91MP0002132_abnormal_respiratory_system0.95740632
92MP0004142_abnormal_muscle_tone0.95124437
93MP0002751_abnormal_autonomic_nervous0.93642392
94MP0000685_abnormal_immune_system0.93472039
95MP0005410_abnormal_fertilization0.92925250
96MP0005076_abnormal_cell_differentiation0.92172657
97MP0001145_abnormal_male_reproductive0.91011715
98MP0000858_altered_metastatic_potential0.90478484
99MP0003890_abnormal_embryonic-extraembry0.89293334
100MP0005075_abnormal_melanosome_morpholog0.89009665
101MP0006276_abnormal_autonomic_nervous0.88922436
102MP0003806_abnormal_nucleotide_metabolis0.88890123
103MP0002160_abnormal_reproductive_system0.88881128
104MP0003186_abnormal_redox_activity0.86972088
105MP0003195_calcinosis0.86234804
106MP0008872_abnormal_physiological_respon0.85410848
107MP0002723_abnormal_immune_serum0.85347777
108MP0001919_abnormal_reproductive_system0.84303706
109MP0000358_abnormal_cell_content/0.84158393
110MP0005671_abnormal_response_to0.84078434
111MP0001929_abnormal_gametogenesis0.82825801
112MP0001485_abnormal_pinna_reflex0.82548130
113MP0002653_abnormal_ependyma_morphology0.81482152
114MP0008875_abnormal_xenobiotic_pharmacok0.79948686
115MP0002161_abnormal_fertility/fecundity0.79667817
116MP0001764_abnormal_homeostasis0.79010778
117MP0001119_abnormal_female_reproductive0.78772704
118MP0005391_vision/eye_phenotype0.78106818
119MP0002405_respiratory_system_inflammati0.77513256
120MP0000647_abnormal_sebaceous_gland0.77246144
121MP0001286_abnormal_eye_development0.76734882
122MP0000653_abnormal_sex_gland0.75900936
123MP0005384_cellular_phenotype0.74907306
124MP0004215_abnormal_myocardial_fiber0.73497540
125MP0002876_abnormal_thyroid_physiology0.72939261
126MP0005389_reproductive_system_phenotype0.72897445
127MP0005621_abnormal_cell_physiology0.72028555
128MP0002095_abnormal_skin_pigmentation0.71921752
129MP0002233_abnormal_nose_morphology0.71331118
130MP0002166_altered_tumor_susceptibility0.70558795
131MP0002127_abnormal_cardiovascular_syste0.70424496
132MP0009379_abnormal_foot_pigmentation0.70122094
133MP0003699_abnormal_female_reproductive0.70066201
134MP0005367_renal/urinary_system_phenotyp0.69665252
135MP0000516_abnormal_urinary_system0.69665252
136MP0002006_tumorigenesis0.69564153
137MP0003656_abnormal_erythrocyte_physiolo0.68677888
138MP0002163_abnormal_gland_morphology0.67576162
139MP0005084_abnormal_gallbladder_morpholo0.66176915
140MP0001324_abnormal_eye_pigmentation0.66130325
141MP0003937_abnormal_limbs/digits/tail_de0.65723444
142MP0005025_abnormal_response_to0.65568332
143MP0000428_abnormal_craniofacial_morphol0.65553750
144MP0001243_abnormal_dermal_layer0.64616051
145MP0002102_abnormal_ear_morphology0.64223828
146MP0005000_abnormal_immune_tolerance0.63142132
147MP0001853_heart_inflammation0.62564879
148MP0006292_abnormal_olfactory_placode0.62491895
149MP0003943_abnormal_hepatobiliary_system0.62378186
150MP0000465_gastrointestinal_hemorrhage0.61651529
151MP0009672_abnormal_birth_weight0.61309871
152MP0003448_altered_tumor_morphology0.60058675
153MP0009703_decreased_birth_body0.58622435
154MP0000477_abnormal_intestine_morphology0.58065266
155MP0005023_abnormal_wound_healing0.57348380
156MP0001915_intracranial_hemorrhage0.56581456
157MP0002111_abnormal_tail_morphology0.55413805
158MP0005174_abnormal_tail_pigmentation0.55294578

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.17364179
2Reticulocytopenia (HP:0001896)4.62747695
3Breast hypoplasia (HP:0003187)4.45976839
4Chromsome breakage (HP:0040012)4.41674171
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.21193298
6Abnormality of cells of the erythroid lineage (HP:0012130)3.83452716
7Abnormal number of erythroid precursors (HP:0012131)3.71638107
8Meckel diverticulum (HP:0002245)3.62936418
9Oral leukoplakia (HP:0002745)3.55497406
10Patellar aplasia (HP:0006443)3.54119170
11Abnormality of chromosome stability (HP:0003220)3.52807832
12Abnormality of the preputium (HP:0100587)3.49608281
13Medulloblastoma (HP:0002885)3.45793987
14Abnormality of the ileum (HP:0001549)3.41533469
15Aplasia/Hypoplasia of the patella (HP:0006498)3.40801112
16Rhabdomyosarcoma (HP:0002859)3.29620268
17Pancreatic cysts (HP:0001737)3.29204142
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.25898438
19Molar tooth sign on MRI (HP:0002419)3.16554081
20Abnormality of midbrain morphology (HP:0002418)3.16554081
21Colon cancer (HP:0003003)3.15042324
22Myelodysplasia (HP:0002863)3.07647390
23Aplastic anemia (HP:0001915)3.04686557
24Pallor (HP:0000980)3.04542450
25Thrombocytosis (HP:0001894)3.04272394
26Pancreatic fibrosis (HP:0100732)3.04158327
27Selective tooth agenesis (HP:0001592)3.03860976
28Acute necrotizing encephalopathy (HP:0006965)2.83782456
29True hermaphroditism (HP:0010459)2.81174039
30Small intestinal stenosis (HP:0012848)2.80893340
31Duodenal stenosis (HP:0100867)2.80893340
32Increased CSF lactate (HP:0002490)2.79792818
33Abnormality of the anterior horn cell (HP:0006802)2.77077311
34Degeneration of anterior horn cells (HP:0002398)2.77077311
35Absent thumb (HP:0009777)2.71064356
36Macrocytic anemia (HP:0001972)2.70680214
37Bone marrow hypocellularity (HP:0005528)2.69364068
38Agnosia (HP:0010524)2.67504872
39Rough bone trabeculation (HP:0100670)2.65868715
40Abnormal mitochondria in muscle tissue (HP:0008316)2.65838818
41Impulsivity (HP:0100710)2.63178128
42Premature graying of hair (HP:0002216)2.60940718
43Carpal bone hypoplasia (HP:0001498)2.60409025
44Mitochondrial inheritance (HP:0001427)2.59145086
45Acute encephalopathy (HP:0006846)2.56897883
46Congenital stationary night blindness (HP:0007642)2.53179867
47Sclerocornea (HP:0000647)2.52922499
48Increased serum lactate (HP:0002151)2.46348281
49Microretrognathia (HP:0000308)2.44931523
50Horseshoe kidney (HP:0000085)2.43047638
51Type I transferrin isoform profile (HP:0003642)2.40846781
52Pendular nystagmus (HP:0012043)2.39024352
53Absent radius (HP:0003974)2.37880606
54Slender long bone (HP:0003100)2.37509615
55Neoplasm of the pancreas (HP:0002894)2.37455186
56Duplicated collecting system (HP:0000081)2.37240335
57Hepatocellular necrosis (HP:0001404)2.36451539
58Cerebral hypomyelination (HP:0006808)2.34972373
59Sloping forehead (HP:0000340)2.34760057
60Increased hepatocellular lipid droplets (HP:0006565)2.34077979
61Progressive macrocephaly (HP:0004481)2.33994181
62Hypoplasia of the pons (HP:0012110)2.31116061
63Lipid accumulation in hepatocytes (HP:0006561)2.30379797
64Abnormality of the pons (HP:0007361)2.29734890
65Nephronophthisis (HP:0000090)2.28583247
66Clubbing of toes (HP:0100760)2.27807332
67Ependymoma (HP:0002888)2.27690951
68Ectopic kidney (HP:0000086)2.27329897
69Hepatic necrosis (HP:0002605)2.26488654
703-Methylglutaconic aciduria (HP:0003535)2.25684599
71Abnormality of the duodenum (HP:0002246)2.25231494
72Tracheoesophageal fistula (HP:0002575)2.20536413
73Absent forearm bone (HP:0003953)2.20273767
74Aplasia involving forearm bones (HP:0009822)2.20273767
75Lymphoma (HP:0002665)2.19981975
76Microvesicular hepatic steatosis (HP:0001414)2.19455524
77Type II lissencephaly (HP:0007260)2.18835348
78Atresia of the external auditory canal (HP:0000413)2.18328424
79Amaurosis fugax (HP:0100576)2.17846315
8011 pairs of ribs (HP:0000878)2.17436207
81Acute lymphatic leukemia (HP:0006721)2.16883856
82Abnormal number of incisors (HP:0011064)2.16609696
83Abnormality of the renal collecting system (HP:0004742)2.15876337
84Abnormal protein glycosylation (HP:0012346)2.15107969
85Abnormal glycosylation (HP:0012345)2.15107969
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15107969
87Abnormal protein N-linked glycosylation (HP:0012347)2.15107969
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14318707
89Pancytopenia (HP:0001876)2.14304575
90Abnormality of the carotid arteries (HP:0005344)2.12879395
91Preaxial hand polydactyly (HP:0001177)2.12572341
92Triphalangeal thumb (HP:0001199)2.12342234
93Neoplasm of striated muscle (HP:0009728)2.11424651
94Abnormality of reticulocytes (HP:0004312)2.11260656
95Basal cell carcinoma (HP:0002671)2.10396780
96Fatigue (HP:0012378)2.10164655
97Attenuation of retinal blood vessels (HP:0007843)2.07042817
98Abnormality of DNA repair (HP:0003254)2.05850034
99Proximal placement of thumb (HP:0009623)2.05843684
100Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05790484
101Aplasia/Hypoplasia of the tibia (HP:0005772)2.04494087
102Abnormality of alanine metabolism (HP:0010916)2.03831160
103Hyperalaninemia (HP:0003348)2.03831160
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03831160
105Cleft eyelid (HP:0000625)2.03728487
106Cellular immunodeficiency (HP:0005374)2.03025728
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02496822
108Multiple enchondromatosis (HP:0005701)2.01619016
109IgM deficiency (HP:0002850)2.01545211
110Abnormal rod and cone electroretinograms (HP:0008323)1.99679046
111Deviation of the thumb (HP:0009603)1.98575326
112Lactic acidosis (HP:0003128)1.98376083
113Squamous cell carcinoma (HP:0002860)1.98184800
114Progressive inability to walk (HP:0002505)1.97832838
115Abnormal lung lobation (HP:0002101)1.97491552
116Abnormal trabecular bone morphology (HP:0100671)1.94982875
117Anencephaly (HP:0002323)1.94786593
118Cafe-au-lait spot (HP:0000957)1.94058177
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.93150004
120Short thumb (HP:0009778)1.93144223
121Granulocytopenia (HP:0001913)1.92768725
122Acute myeloid leukemia (HP:0004808)1.92440292
123Bile duct proliferation (HP:0001408)1.91436372
124Abnormal biliary tract physiology (HP:0012439)1.91436372
125Trismus (HP:0000211)1.91030170
126Ureteral duplication (HP:0000073)1.90447968
127Renal Fanconi syndrome (HP:0001994)1.89938181
128Cerebral edema (HP:0002181)1.88452397
129Abnormality of pyrimidine metabolism (HP:0004353)1.88278136
130Hypoplasia of the fovea (HP:0007750)1.85709671
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.85709671
132Abnormality of the renal medulla (HP:0100957)1.85210408
133Abnormality of abdominal situs (HP:0011620)1.85072047
134Abdominal situs inversus (HP:0003363)1.85072047
135Medial flaring of the eyebrow (HP:0010747)1.84872442
136Abnormality of the heme biosynthetic pathway (HP:0010472)1.84791372
137Short tibia (HP:0005736)1.84619765
138Abnormality of the renal cortex (HP:0011035)1.83726709
139Muscle fiber atrophy (HP:0100295)1.83473751
140Leukopenia (HP:0001882)1.81975021
141Supernumerary spleens (HP:0009799)1.80867542
142Methylmalonic acidemia (HP:0002912)1.80553242
143Cystic liver disease (HP:0006706)1.80492909
144Lissencephaly (HP:0001339)1.79496288
145High pitched voice (HP:0001620)1.79256911
146Retinal dysplasia (HP:0007973)1.78912828
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78574592
148Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78574592
149Glioma (HP:0009733)1.77990662
150Optic disc pallor (HP:0000543)1.77067873
151Prominent nose (HP:0000448)1.76931083
152Increased nuchal translucency (HP:0010880)1.76407871
153Volvulus (HP:0002580)1.75922849
154Abnormality of the labia minora (HP:0012880)1.75308858
155Arteriovenous malformation (HP:0100026)1.74265146
156Secondary amenorrhea (HP:0000869)1.73888801
157Abnormality of the umbilical cord (HP:0010881)1.73519681
158Abnormality of lateral ventricle (HP:0030047)1.72766355
159Elevated erythrocyte sedimentation rate (HP:0003565)1.72059606
160Exertional dyspnea (HP:0002875)1.69766771
161Premature ovarian failure (HP:0008209)1.69474958
162Aplasia/Hypoplasia of the sternum (HP:0006714)1.69443943
163Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69268329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.42811575
2BUB14.36550600
3STK164.29235870
4CDC73.88329810
5NEK23.26348967
6EIF2AK13.15416976
7BRSK23.13322444
8VRK23.09360872
9FRK2.74468819
10NME22.48339316
11ACVR1B2.31764989
12SRPK12.11256809
13VRK12.07585516
14TLK12.05870257
15TTK1.98293193
16PLK11.95670875
17MAP4K21.91448117
18NEK11.87273748
19TRIM281.84104459
20EIF2AK31.82294785
21PLK41.79301986
22BRSK11.76185464
23RPS6KA41.69854598
24TESK21.67736076
25AURKB1.65622609
26MAP4K11.64417665
27NME11.63311689
28DYRK31.62508638
29MKNK11.62349875
30CDK121.59643601
31BMPR1B1.58639468
32WNK31.55119318
33PBK1.53044463
34ATR1.51185340
35MKNK21.45252385
36TSSK61.44857248
37CDK71.44279086
38CDK41.42915468
39GRK11.40862555
40CHEK21.34028590
41ADRBK21.32229736
42PLK31.31165229
43TAF11.30005330
44SCYL21.27078520
45PASK1.26948520
46MAP3K81.24766140
47CCNB11.17935551
48BCKDK1.15185620
49STK101.14936165
50RPS6KB21.13254777
51ZAK1.12873083
52AURKA1.11566686
53FLT31.10005339
54CHEK11.09299028
55CSNK1G31.07998032
56WNK41.01809128
57STK41.01474557
58CSNK1G11.00356374
59TAOK30.96445296
60CSNK1A1L0.91305083
61NEK90.91135246
62TGFBR10.89507300
63PIM10.88049571
64CSNK1G20.84290639
65ATM0.81961384
66MAP3K40.81042103
67MAP3K100.79979449
68JAK30.79883237
69ZAP700.79631847
70TEC0.77909287
71EPHA20.77556935
72STK30.76961257
73EIF2AK20.76940722
74INSRR0.75875127
75CDK20.75326006
76STK390.74898815
77MAP2K70.73166128
78PLK20.69247365
79MAPKAPK50.69218227
80PDK20.68470920
81LRRK20.67246247
82PINK10.65241496
83KIT0.64945066
84EEF2K0.64455080
85MAPK130.63365986
86MAP2K30.62670303
87TYK20.62070197
88CSNK2A10.59549687
89PIM20.58421101
90TXK0.57990341
91PAK40.57970430
92CSNK2A20.57934447
93PAK10.57727204
94MELK0.57642587
95CDK30.57416563
96BRD40.54139710
97CDK80.53778121
98BLK0.53423224
99BTK0.52206716
100ARAF0.51603044
101BRAF0.50880986
102CDK10.50461955
103CDK60.50080003
104OXSR10.49182579
105CSF1R0.48192072
106GRK60.47073303
107TESK10.44561053
108PRKCE0.44204134
109PRKCG0.44078902
110KDR0.43816537
111MAP3K110.43544275
112NLK0.43012748
113CSNK1E0.38967011
114PKN20.38950593
115ALK0.38669066
116RPS6KA50.36985888
117IKBKB0.36412222
118CLK10.35782580
119LATS10.35257006
120CDK190.35127382
121TNIK0.33935257
122LATS20.32956200
123NUAK10.32338774
124BCR0.31883268
125SYK0.31531504
126DYRK20.30835174
127AKT20.29946363
128CSNK1A10.29702880
129IRAK40.29558034
130RIPK10.28834785
131CSNK1D0.28515739
132CASK0.28437754
133STK38L0.26781589
134RAF10.26504290
135MARK30.26179513
136ADRBK10.25965484
137MAPK110.25073465
138STK240.25022652
139PKN10.24096208
140LCK0.23549049
141LYN0.23009365
142MST40.22734014
143PRKDC0.22657394
144PRKCI0.21704213

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.39338561
2Mismatch repair_Homo sapiens_hsa034304.26245322
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31590347
4Ribosome_Homo sapiens_hsa030103.28091890
5Base excision repair_Homo sapiens_hsa034103.15038251
6Homologous recombination_Homo sapiens_hsa034403.13155633
7RNA polymerase_Homo sapiens_hsa030203.04829061
8Spliceosome_Homo sapiens_hsa030402.96615085
9Proteasome_Homo sapiens_hsa030502.96519104
10Cell cycle_Homo sapiens_hsa041102.93540076
11RNA transport_Homo sapiens_hsa030132.87680891
12Nucleotide excision repair_Homo sapiens_hsa034202.80306892
13One carbon pool by folate_Homo sapiens_hsa006702.55767849
14Pyrimidine metabolism_Homo sapiens_hsa002402.54445634
15Oxidative phosphorylation_Homo sapiens_hsa001902.30975448
16Fanconi anemia pathway_Homo sapiens_hsa034602.29575318
17Parkinsons disease_Homo sapiens_hsa050122.07183712
18Non-homologous end-joining_Homo sapiens_hsa034502.02403823
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93449258
20p53 signaling pathway_Homo sapiens_hsa041151.81632368
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80753468
22RNA degradation_Homo sapiens_hsa030181.80644262
23Basal transcription factors_Homo sapiens_hsa030221.62552431
24mRNA surveillance pathway_Homo sapiens_hsa030151.58774840
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58265909
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44533449
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35543267
28Systemic lupus erythematosus_Homo sapiens_hsa053221.30855738
29Epstein-Barr virus infection_Homo sapiens_hsa051691.30648746
30Purine metabolism_Homo sapiens_hsa002301.29254849
31Antigen processing and presentation_Homo sapiens_hsa046121.19887297
32Phototransduction_Homo sapiens_hsa047441.17679006
33Herpes simplex infection_Homo sapiens_hsa051681.16940783
34Alzheimers disease_Homo sapiens_hsa050101.12200648
35Butanoate metabolism_Homo sapiens_hsa006501.08326877
36Oocyte meiosis_Homo sapiens_hsa041141.06897259
37Propanoate metabolism_Homo sapiens_hsa006401.04591096
38Regulation of autophagy_Homo sapiens_hsa041401.01861142
39Viral carcinogenesis_Homo sapiens_hsa052030.98416886
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97719823
41Pentose phosphate pathway_Homo sapiens_hsa000300.97027064
42Fatty acid elongation_Homo sapiens_hsa000620.96620220
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93781442
44Vitamin B6 metabolism_Homo sapiens_hsa007500.93245081
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91553376
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.91141084
47Primary immunodeficiency_Homo sapiens_hsa053400.88908336
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88105353
49Folate biosynthesis_Homo sapiens_hsa007900.82136813
50HTLV-I infection_Homo sapiens_hsa051660.80870210
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76082096
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75521540
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.74433301
54Metabolic pathways_Homo sapiens_hsa011000.74173155
55Tryptophan metabolism_Homo sapiens_hsa003800.72650533
56Cardiac muscle contraction_Homo sapiens_hsa042600.71055315
57Linoleic acid metabolism_Homo sapiens_hsa005910.70424126
58Measles_Homo sapiens_hsa051620.69812658
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.69185934
60Small cell lung cancer_Homo sapiens_hsa052220.67746307
61Thyroid cancer_Homo sapiens_hsa052160.67282797
62Biosynthesis of amino acids_Homo sapiens_hsa012300.65853612
63Steroid biosynthesis_Homo sapiens_hsa001000.65712088
64Apoptosis_Homo sapiens_hsa042100.65053950
65Pyruvate metabolism_Homo sapiens_hsa006200.65050760
66Legionellosis_Homo sapiens_hsa051340.64651592
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64095565
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63557266
69MicroRNAs in cancer_Homo sapiens_hsa052060.63234625
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.61161756
71Protein export_Homo sapiens_hsa030600.60957025
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60040873
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.58609678
74Nitrogen metabolism_Homo sapiens_hsa009100.56547736
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56338243
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55496271
77Hepatitis B_Homo sapiens_hsa051610.55201228
78Shigellosis_Homo sapiens_hsa051310.55052919
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54399665
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54313924
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53598099
82beta-Alanine metabolism_Homo sapiens_hsa004100.53057426
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52318281
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52072979
85Taste transduction_Homo sapiens_hsa047420.52070544
86Caffeine metabolism_Homo sapiens_hsa002320.50011231
87Sulfur relay system_Homo sapiens_hsa041220.49016572
88Fructose and mannose metabolism_Homo sapiens_hsa000510.48607920
89Peroxisome_Homo sapiens_hsa041460.48493790
90Ether lipid metabolism_Homo sapiens_hsa005650.48101312
91Olfactory transduction_Homo sapiens_hsa047400.47293069
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.45327927
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42950239
94Arginine and proline metabolism_Homo sapiens_hsa003300.40343247
95Sulfur metabolism_Homo sapiens_hsa009200.39590230
96Influenza A_Homo sapiens_hsa051640.38761220
97Fatty acid metabolism_Homo sapiens_hsa012120.38314317
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37828692
99Selenocompound metabolism_Homo sapiens_hsa004500.37311351
100Chronic myeloid leukemia_Homo sapiens_hsa052200.36956053
101TGF-beta signaling pathway_Homo sapiens_hsa043500.35879509
102Hematopoietic cell lineage_Homo sapiens_hsa046400.35750115
103Leishmaniasis_Homo sapiens_hsa051400.35654717
104Alcoholism_Homo sapiens_hsa050340.35622867
105Nicotine addiction_Homo sapiens_hsa050330.35110922
106Viral myocarditis_Homo sapiens_hsa054160.33981830
107Allograft rejection_Homo sapiens_hsa053300.33945309
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33814492
109N-Glycan biosynthesis_Homo sapiens_hsa005100.32582512
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31680093
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31005435
112Colorectal cancer_Homo sapiens_hsa052100.29377478
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28537038
114Glutathione metabolism_Homo sapiens_hsa004800.27436729
115Carbon metabolism_Homo sapiens_hsa012000.26232455
116Lysine degradation_Homo sapiens_hsa003100.26120335
117HIF-1 signaling pathway_Homo sapiens_hsa040660.26068236
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25892972
119Notch signaling pathway_Homo sapiens_hsa043300.25499203
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24447023
121Pathways in cancer_Homo sapiens_hsa052000.23398818
122Bladder cancer_Homo sapiens_hsa052190.23114021
123Acute myeloid leukemia_Homo sapiens_hsa052210.22415846
124B cell receptor signaling pathway_Homo sapiens_hsa046620.22304878
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22145186
126Hippo signaling pathway_Homo sapiens_hsa043900.22007013
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21648682
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21527275
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.20836602
130Huntingtons disease_Homo sapiens_hsa050160.20563032
131Chemical carcinogenesis_Homo sapiens_hsa052040.20266619
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19799270
133Graft-versus-host disease_Homo sapiens_hsa053320.19526818
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19120307
135Toxoplasmosis_Homo sapiens_hsa051450.18659246
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.18080035
137ABC transporters_Homo sapiens_hsa020100.18031841
138Ovarian steroidogenesis_Homo sapiens_hsa049130.17560183
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17434254
140Fatty acid degradation_Homo sapiens_hsa000710.17030043
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17004321
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15149646
1432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14326770
144Prostate cancer_Homo sapiens_hsa052150.13144157
145Asthma_Homo sapiens_hsa053100.13033011
146T cell receptor signaling pathway_Homo sapiens_hsa046600.12923529
147Galactose metabolism_Homo sapiens_hsa000520.12040662
148Basal cell carcinoma_Homo sapiens_hsa052170.11619998
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.11194049
150Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11182187

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »