GIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dentate gyrus development (GO:0021542)9.64352526
2proline metabolic process (GO:0006560)9.11984220
3positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)8.20005898
4regulation of respiratory burst (GO:0060263)7.82754551
5regulation of hydrogen peroxide metabolic process (GO:0010310)7.46569188
6regulation of meiosis I (GO:0060631)7.04447942
7glutamine family amino acid biosynthetic process (GO:0009084)6.72004175
8calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.68004001
9piRNA metabolic process (GO:0034587)6.63375723
10regulation of substrate adhesion-dependent cell spreading (GO:1900024)6.63193264
11negative regulation of glial cell proliferation (GO:0060253)6.60650692
12positive regulation of digestive system process (GO:0060456)6.28459126
13membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.14679921
14potassium ion export (GO:0071435)5.97069732
15digestive system process (GO:0022600)5.75575865
16cardiovascular system development (GO:0072358)5.64656046
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61460937
18ribosomal small subunit assembly (GO:0000028)5.56014007
19chaperone-mediated protein transport (GO:0072321)5.44119449
20membrane repolarization during action potential (GO:0086011)5.40189899
21atrial cardiac muscle cell action potential (GO:0086014)5.28507154
22ribosomal small subunit biogenesis (GO:0042274)5.05684391
23intestinal epithelial cell development (GO:0060576)4.99862080
24rRNA modification (GO:0000154)4.96866747
25energy coupled proton transport, down electrochemical gradient (GO:0015985)4.96064123
26ATP synthesis coupled proton transport (GO:0015986)4.96064123
27negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)4.96011418
28male meiosis I (GO:0007141)4.95774138
29cellular response to epinephrine stimulus (GO:0071872)4.94079068
30cell differentiation involved in embryonic placenta development (GO:0060706)4.81581331
31formation of translation preinitiation complex (GO:0001731)4.69832560
32negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.63827830
33mitotic metaphase plate congression (GO:0007080)4.49040418
34meiosis I (GO:0007127)4.44942493
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.43932581
36transcription from mitochondrial promoter (GO:0006390)4.43224085
37proteasome assembly (GO:0043248)4.41489735
38viral transcription (GO:0019083)4.38303861
39L-serine transport (GO:0015825)4.38055846
40translational termination (GO:0006415)4.27045652
41hepatocyte apoptotic process (GO:0097284)4.26842798
42ribosomal large subunit biogenesis (GO:0042273)4.24915787
43male meiosis (GO:0007140)4.18226091
44rRNA methylation (GO:0031167)4.16328338
45transcription elongation from RNA polymerase III promoter (GO:0006385)4.15244005
46termination of RNA polymerase III transcription (GO:0006386)4.15244005
47regulation of mitochondrial translation (GO:0070129)4.13895273
48regulation of phagocytosis (GO:0050764)4.13204726
49positive regulation of gastrulation (GO:2000543)3.94963061
50maturation of SSU-rRNA (GO:0030490)3.94325062
51translational initiation (GO:0006413)3.92472553
52response to epinephrine (GO:0071871)3.91337588
53mitotic chromosome condensation (GO:0007076)3.89792895
54ribonucleoprotein complex biogenesis (GO:0022613)3.87824988
55DNA methylation involved in gamete generation (GO:0043046)3.83820113
56visual learning (GO:0008542)3.82467105
57DNA replication checkpoint (GO:0000076)3.82333630
58membrane repolarization (GO:0086009)3.81180514
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80608351
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.80608351
61serine transport (GO:0032329)3.80428197
62GDP-mannose metabolic process (GO:0019673)3.79970239
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.78527038
64CENP-A containing nucleosome assembly (GO:0034080)3.76409431
65metaphase plate congression (GO:0051310)3.75939378
66negative regulation of meiosis (GO:0045835)3.74346743
67regulation of glial cell proliferation (GO:0060251)3.73766951
68chromatin remodeling at centromere (GO:0031055)3.73352105
69ventricular cardiac muscle cell action potential (GO:0086005)3.73194265
70translational elongation (GO:0006414)3.72223047
71positive regulation of meiosis (GO:0045836)3.71813210
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.71695132
73positive regulation of chemokine secretion (GO:0090197)3.70057418
74NADH metabolic process (GO:0006734)3.68810871
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66128973
76rRNA processing (GO:0006364)3.63597885
77positive regulation of meiotic cell cycle (GO:0051446)3.62121482
78secretion by tissue (GO:0032941)3.61506175
79cotranslational protein targeting to membrane (GO:0006613)3.57258500
80galactose catabolic process (GO:0019388)3.54423110
81ribosome assembly (GO:0042255)3.54259819
82protein targeting to ER (GO:0045047)3.50466474
83primary alcohol metabolic process (GO:0034308)3.50249191
84positive regulation of potassium ion transmembrane transport (GO:1901381)3.49658642
85rRNA metabolic process (GO:0016072)3.48712570
86intestinal absorption (GO:0050892)3.43954484
87regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43632013
88oxidative phosphorylation (GO:0006119)3.42129649
89ribosome biogenesis (GO:0042254)3.40304537
90regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.39414414
91viral life cycle (GO:0019058)3.39316009
92visual behavior (GO:0007632)3.38815557
93meiotic nuclear division (GO:0007126)3.35689955
94cellular protein complex disassembly (GO:0043624)3.34711283
95establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34585655
96protein localization to endoplasmic reticulum (GO:0070972)3.32081115
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31521428
98protein targeting to mitochondrion (GO:0006626)3.30047712
99negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.29805623
100translation (GO:0006412)3.29462162
101synapsis (GO:0007129)3.29001036
102mitotic sister chromatid cohesion (GO:0007064)3.28366714
103autophagic vacuole assembly (GO:0000045)3.27595590
104regulation of G0 to G1 transition (GO:0070316)3.26499318
105head development (GO:0060322)3.25994991
106pentose-phosphate shunt (GO:0006098)3.23100178
107negative regulation of keratinocyte proliferation (GO:0010839)3.22950604
108urea cycle (GO:0000050)3.22642775
109urea metabolic process (GO:0019627)3.22642775
110cellular component biogenesis (GO:0044085)3.21881959
111protein-cofactor linkage (GO:0018065)3.20119293
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19531206
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19531206
114regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19392388
115oogenesis (GO:0048477)3.16627774
116telomere maintenance via semi-conservative replication (GO:0032201)3.14594887
117histone exchange (GO:0043486)3.14097267
118body fluid secretion (GO:0007589)3.12107822
119pseudouridine synthesis (GO:0001522)3.10570381
120mitochondrial RNA metabolic process (GO:0000959)3.10424606
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07088443
122UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06750154
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05721235
124DNA replication initiation (GO:0006270)3.05186416
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04307098
126ventricular cardiac muscle cell development (GO:0055015)3.02845406
127regulation of heart rate by cardiac conduction (GO:0086091)3.01206917
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99506848
129establishment of protein localization to mitochondrion (GO:0072655)2.98224034
130respiratory electron transport chain (GO:0022904)2.98006321
131growth hormone secretion (GO:0030252)2.97752892
132positive regulation of chromosome segregation (GO:0051984)2.97601449
133erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.97482373
134L-phenylalanine metabolic process (GO:0006558)2.97482373
135positive regulation of pseudopodium assembly (GO:0031274)2.96212163
136electron transport chain (GO:0022900)2.95278833
137NADPH regeneration (GO:0006740)2.94046314
138nucleoside diphosphate biosynthetic process (GO:0009133)2.93909204
139protein localization to mitochondrion (GO:0070585)2.93668407
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89482758
141regulation of chemokine secretion (GO:0090196)2.88479189
142resolution of meiotic recombination intermediates (GO:0000712)2.88183900
143protein K6-linked ubiquitination (GO:0085020)2.87880567
144positive regulation of protein homooligomerization (GO:0032464)2.87118863
145regulation of chromosome segregation (GO:0051983)2.86701514
146negative regulation of insulin secretion (GO:0046676)2.85295129
147sulfur amino acid catabolic process (GO:0000098)2.85215009
148nitrogen cycle metabolic process (GO:0071941)2.84813703
149meiotic cell cycle process (GO:1903046)2.84728332
150DNA deamination (GO:0045006)2.84231863
151ncRNA 3-end processing (GO:0043628)2.81938004
152meiotic cell cycle (GO:0051321)2.81291494
153protein maturation by protein folding (GO:0022417)2.81139381
154regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.80252252
155regulation of cholesterol homeostasis (GO:2000188)2.79996455
156nuclear-transcribed mRNA catabolic process (GO:0000956)2.79925740
157eyelid development in camera-type eye (GO:0061029)2.79653172
158regulation of spindle organization (GO:0090224)2.79154157
159tricarboxylic acid cycle (GO:0006099)2.78808797
160positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78589417
161maturation of 5.8S rRNA (GO:0000460)2.77237354
162negative regulation of interleukin-1 beta production (GO:0032691)2.76669628
163negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76427674
164negative regulation of ligase activity (GO:0051352)2.76427674
165protein complex disassembly (GO:0043241)2.75760455
166regulation of digestive system process (GO:0044058)2.75241168
167RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.74879251
168negative regulation of signal transduction by p53 class mediator (GO:1901797)2.70874762
169establishment of chromosome localization (GO:0051303)2.70638574
170telomere maintenance via telomere lengthening (GO:0010833)2.69855432
171regulation of gene silencing by miRNA (GO:0060964)2.69509238
172diol metabolic process (GO:0034311)2.68804539
173killing of cells of other organism (GO:0031640)2.68163934
174disruption of cells of other organism (GO:0044364)2.68163934
175embryonic skeletal joint morphogenesis (GO:0060272)2.68077922
176* endocrine pancreas development (GO:0031018)2.68029716
177ATP biosynthetic process (GO:0006754)2.58248165
178decidualization (GO:0046697)2.57600698
179negative regulation of immune response (GO:0050777)2.57289045
180negative regulation of interleukin-1 production (GO:0032692)2.57205132
181cytidine deamination (GO:0009972)2.56782644
182cytidine metabolic process (GO:0046087)2.56782644
183cytidine catabolic process (GO:0006216)2.56782644
184cardiac conduction (GO:0061337)2.55851023
185regulation of metalloenzyme activity (GO:0048552)2.54546752
186bone morphogenesis (GO:0060349)2.54494505
187intestinal cholesterol absorption (GO:0030299)2.54161344
188erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.49021327
189L-phenylalanine catabolic process (GO:0006559)2.49021327
190associative learning (GO:0008306)2.48304186
191succinate metabolic process (GO:0006105)2.47171872
192citrulline biosynthetic process (GO:0019240)2.45977224
193regulation of cellular extravasation (GO:0002691)16.0313468
194primary alcohol catabolic process (GO:0034310)12.8486783
195proline biosynthetic process (GO:0006561)12.6794231
196neuronal stem cell maintenance (GO:0097150)12.4895109
197negative regulation of retinoic acid receptor signaling pathway (GO:0048387)12.1025780
198ethanol metabolic process (GO:0006067)11.1902907
199regulation of retinoic acid receptor signaling pathway (GO:0048385)10.2808699
200regulation of necrotic cell death (GO:0010939)10.0003392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.26819652
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse5.75642929
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.78918014
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.19274592
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97554627
6EZH2_22144423_ChIP-Seq_EOC_Human3.90994449
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.70252603
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.63705971
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53469998
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.33117477
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27336148
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21038417
13* CDX2_20551321_ChIP-Seq_CACO-2_Human3.06697768
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.04709535
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.99147930
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.92910195
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87161803
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.84892358
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.84892358
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.84892358
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83399504
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74730255
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63061153
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55756255
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53632612
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.48016217
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.45667063
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.39889912
29VDR_23849224_ChIP-Seq_CD4+_Human2.39737038
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36668721
31TTF2_22483619_ChIP-Seq_HELA_Human2.36405601
32GATA4_25053715_ChIP-Seq_YYC3_Human2.32672528
33RXR_22158963_ChIP-Seq_LIVER_Mouse2.31943581
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28392810
35GATA6_25053715_ChIP-Seq_YYC3_Human2.27259191
36ZNF263_19887448_ChIP-Seq_K562_Human2.22101582
37FOXM1_23109430_ChIP-Seq_U2OS_Human2.20546904
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20454848
39E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17613558
40SOX2_27498859_Chip-Seq_STOMACH_Mouse2.16313466
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15754871
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.13515052
43FOXP3_21729870_ChIP-Seq_TREG_Human2.12319255
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11133318
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.11052067
46GABP_19822575_ChIP-Seq_HepG2_Human2.06630179
47DCP1A_22483619_ChIP-Seq_HELA_Human2.03847305
48SOX2_20726797_ChIP-Seq_SW620_Human2.01877260
49LXR_22292898_ChIP-Seq_THP-1_Human1.98352155
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.95060960
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94363932
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92588988
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88806745
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86213318
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.83569150
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.80540476
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77297043
58LXR_22158963_ChIP-Seq_LIVER_Mouse1.76344895
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.76093790
60ELK1_19687146_ChIP-ChIP_HELA_Human1.75004167
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.74631089
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70838948
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69711554
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69644305
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68390086
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67608220
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.66290322
68TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.65507265
69ATF3_27146783_Chip-Seq_COLON_Human1.62650730
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58573905
71NANOG_20526341_ChIP-Seq_ESCs_Human1.56826811
72RACK7_27058665_Chip-Seq_MCF-7_Human1.56790794
73ZNF274_21170338_ChIP-Seq_K562_Hela1.55191711
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52272486
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52187259
76E2F7_22180533_ChIP-Seq_HELA_Human1.51004311
77* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.50504376
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.49636056
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45967050
80PHF8_20622854_ChIP-Seq_HELA_Human1.43567257
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41186260
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39941849
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.39382315
84AR_21909140_ChIP-Seq_LNCAP_Human1.38436274
85P68_20966046_ChIP-Seq_HELA_Human1.37175200
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36829588
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35678113
88* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34017841
89SA1_27219007_Chip-Seq_Bcells_Human1.32115603
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.30417767
91STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30048481
92* CTCF_27219007_Chip-Seq_Bcells_Human1.29895730
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29785102
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29164939
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27597694
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27408332
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24216106
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22018728
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21178594
100TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20539508
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.19842520
102STAT1_20625510_ChIP-Seq_HELA_Human1.19129370
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18653093
104GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.18442632
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17079886
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15711328
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.14938860
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14237333
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13953748
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12795429
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12515928
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12190572
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12042757
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11153226
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10999190
116ESR1_21235772_ChIP-Seq_MCF-7_Human1.10841683
117CTCF_20526341_ChIP-Seq_ESCs_Human1.10613968
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10573526
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10426766
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09768895
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09050276
122CREB1_26743006_Chip-Seq_LNCaP_Human1.08816699
123BCL6_27268052_Chip-Seq_Bcells_Human1.08324924
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08110129
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.07711895
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04926688
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04580658
128MYC_18940864_ChIP-ChIP_HL60_Human1.04433115
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03888130
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03877445
131SMC4_20622854_ChIP-Seq_HELA_Human1.02654556
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01806070
133SOX17_20123909_ChIP-Seq_XEN_Mouse1.01373687
134KDM5A_27292631_Chip-Seq_BREAST_Human1.01328452
135NANOG_16153702_ChIP-ChIP_HESCs_Human1.01081776
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01048697
137ELK1_22589737_ChIP-Seq_MCF10A_Human1.01012134
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00854607
139SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00254966
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00185110
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98157195
142VDR_21846776_ChIP-Seq_THP-1_Human0.97853608
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97760700
144MYC_18555785_ChIP-Seq_MESCs_Mouse0.96594330
145* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96198170
146SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95839203
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95775237
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95654798
149SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95570888
150* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95560262
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94968508
152BCOR_27268052_Chip-Seq_Bcells_Human0.94414752
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94160960
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94146400
155E2F1_20622854_ChIP-Seq_HELA_Human0.93893928
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93621723
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93354813
158TFEB_21752829_ChIP-Seq_HELA_Human0.92321404
159DROSHA_22980978_ChIP-Seq_HELA_Human0.91945433
160UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91915874
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90315863
162CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89912699
163SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88795362
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87756153
165XRN2_22483619_ChIP-Seq_HELA_Human0.87712636
166TP63_22573176_ChIP-Seq_HFKS_Human0.87440775
167IRF1_19129219_ChIP-ChIP_H3396_Human0.87242627
168NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87159566
169PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86157748
170MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85214095
171JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84751282
172E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84518057
173SOX2_16153702_ChIP-ChIP_HESCs_Human0.83976571
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83737872
175MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83737643
176KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83723742
177ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82776817
178ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82239882
179YY1_22570637_ChIP-Seq_MALME-3M_Human0.81572805
180TP53_22573176_ChIP-Seq_HFKS_Human0.81208000
181CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80322788
182FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79110415
183CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78450145
184LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.76851954
185BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76242445
186CIITA_25753668_ChIP-Seq_RAJI_Human0.75398989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation9.52187875
2MP0003123_paternal_imprinting6.37410109
3MP0008004_abnormal_stomach_pH5.85593632
4MP0003787_abnormal_imprinting4.86464497
5MP0008058_abnormal_DNA_repair3.89557216
6MP0001663_abnormal_digestive_system3.78071643
7MP0001986_abnormal_taste_sensitivity3.73984117
8MP0008877_abnormal_DNA_methylation3.72459149
9MP0006292_abnormal_olfactory_placode3.52672570
10MP0000537_abnormal_urethra_morphology3.30455905
11MP0003111_abnormal_nucleus_morphology3.19536950
12MP0000490_abnormal_crypts_of3.15851518
13MP0004264_abnormal_extraembryonic_tissu3.09090241
14MP0002139_abnormal_hepatobiliary_system3.07310339
15MP0008260_abnormal_autophagy3.06318092
16MP0005423_abnormal_somatic_nervous3.02547388
17MP0005381_digestive/alimentary_phenotyp2.98711393
18MP0010368_abnormal_lymphatic_system2.98051799
19MP0003806_abnormal_nucleotide_metabolis2.97112077
20MP0010094_abnormal_chromosome_stability2.96259190
21MP0003718_maternal_effect2.96199987
22MP0003077_abnormal_cell_cycle2.93890500
23MP0005360_urolithiasis2.89069460
24MP0010234_abnormal_vibrissa_follicle2.86831600
25MP0000462_abnormal_digestive_system2.76862500
26MP0010352_gastrointestinal_tract_polyps2.50644720
27MP0002210_abnormal_sex_determination2.30940054
28MP0001485_abnormal_pinna_reflex2.26703202
29MP0002909_abnormal_adrenal_gland2.25177971
30MP0003866_abnormal_defecation2.21450903
31MP0002160_abnormal_reproductive_system2.17008828
32MP0008057_abnormal_DNA_replication2.14958271
33MP0001666_abnormal_nutrient_absorption2.11493182
34MP0001929_abnormal_gametogenesis2.08889326
35MP0008932_abnormal_embryonic_tissue2.07812256
36MP0010155_abnormal_intestine_physiology2.04801354
37MP0003186_abnormal_redox_activity1.98880970
38MP0003646_muscle_fatigue1.93304567
39MP0003300_gastrointestinal_ulcer1.84366515
40MP0008872_abnormal_physiological_respon1.80793764
41MP0001348_abnormal_lacrimal_gland1.69303683
42MP0001145_abnormal_male_reproductive1.66639469
43MP0003121_genomic_imprinting1.64486913
44MP0000653_abnormal_sex_gland1.63476328
45MP0005085_abnormal_gallbladder_physiolo1.59401457
46MP0000358_abnormal_cell_content/1.57231979
47MP0003950_abnormal_plasma_membrane1.51049003
48MP0003705_abnormal_hypodermis_morpholog1.47823942
49MP0000477_abnormal_intestine_morphology1.46713963
50MP0009333_abnormal_splenocyte_physiolog1.46111647
51MP0000350_abnormal_cell_proliferation1.45992185
52MP0005389_reproductive_system_phenotype1.42177824
53MP0010307_abnormal_tumor_latency1.37058183
54MP0002127_abnormal_cardiovascular_syste1.35532935
55MP0002254_reproductive_system_inflammat1.35266268
56MP0001697_abnormal_embryo_size1.33390373
57MP0003698_abnormal_male_reproductive1.33285387
58MP0001672_abnormal_embryogenesis/_devel1.33207794
59MP0005380_embryogenesis_phenotype1.33207794
60MP0005332_abnormal_amino_acid1.27283305
61MP0001664_abnormal_digestion1.25227608
62MP0001346_abnormal_lacrimal_gland1.22859595
63MP0003828_pulmonary_edema1.19683991
64MP0003315_abnormal_perineum_morphology1.19059697
65MP0005174_abnormal_tail_pigmentation1.15437785
66MP0002085_abnormal_embryonic_tissue1.15394805
67MP0005365_abnormal_bile_salt1.13804237
68MP0009643_abnormal_urine_homeostasis1.13357971
69MP0008875_abnormal_xenobiotic_pharmacok1.11743868
70MP0003938_abnormal_ear_development1.10971468
71MP0003936_abnormal_reproductive_system1.10836415
72MP0003567_abnormal_fetal_cardiomyocyte1.10568177
73MP0003137_abnormal_impulse_conducting1.09513110
74MP0002084_abnormal_developmental_patter1.09196131
75MP0008007_abnormal_cellular_replicative1.06482434
76MP0005670_abnormal_white_adipose1.06414088
77MP0002080_prenatal_lethality1.06375014
78MP0000313_abnormal_cell_death1.05466327
79MP0003191_abnormal_cellular_cholesterol1.05054760
80MP0002161_abnormal_fertility/fecundity1.04654052
81MP0002163_abnormal_gland_morphology1.04410331
82MP0001119_abnormal_female_reproductive1.04009239
83MP0003984_embryonic_growth_retardation1.03897626
84MP0003786_premature_aging1.03309867
85MP0000647_abnormal_sebaceous_gland1.01314077
86MP0001764_abnormal_homeostasis1.00935179
87MP0001849_ear_inflammation1.00704976
88MP0000750_abnormal_muscle_regeneration0.99871491
89MP0002088_abnormal_embryonic_growth/wei0.98866682
90MP0001293_anophthalmia0.98176708
91MP0003699_abnormal_female_reproductive0.95140215
92MP0003724_increased_susceptibility_to0.93520034
93MP0003119_abnormal_digestive_system0.92278660
94MP0004883_abnormal_blood_vessel0.91390844
95MP0004957_abnormal_blastocyst_morpholog0.91004275
96MP0000470_abnormal_stomach_morphology0.90250484
97MP0002138_abnormal_hepatobiliary_system0.89572809
98MP0002693_abnormal_pancreas_physiology0.89442780
99MP0002277_abnormal_respiratory_mucosa0.88074562
100MP0005395_other_phenotype0.86743949
101MP0004782_abnormal_surfactant_physiolog0.85349194
102MP0009697_abnormal_copulation0.84133363
103MP0003937_abnormal_limbs/digits/tail_de0.83750430
104MP0010329_abnormal_lipoprotein_level0.83574597
105MP0004147_increased_porphyrin_level0.83329726
106MP0008995_early_reproductive_senescence0.81828262
107MP0003635_abnormal_synaptic_transmissio0.80740084
108MP0002233_abnormal_nose_morphology0.80533666
109MP0004019_abnormal_vitamin_homeostasis0.79367753
110MP0009840_abnormal_foam_cell0.77537110
111MP0004270_analgesia0.77498114
112MP0002796_impaired_skin_barrier0.76907846
113MP0005166_decreased_susceptibility_to0.76653002
114MP0008789_abnormal_olfactory_epithelium0.74166555
115MP0005501_abnormal_skin_physiology0.73877698
116MP0009379_abnormal_foot_pigmentation0.73745989
117MP0000749_muscle_degeneration0.70775004
118MP0002098_abnormal_vibrissa_morphology0.70567754
119MP0004859_abnormal_synaptic_plasticity0.70549613
120MP0006036_abnormal_mitochondrial_physio0.70031660
121MP0002822_catalepsy0.69190541
122MP0003890_abnormal_embryonic-extraembry0.69084728
123MP0000678_abnormal_parathyroid_gland0.68774169
124MP0004484_altered_response_of0.67854568
125MP0001542_abnormal_bone_strength0.67747842
126MP0000015_abnormal_ear_pigmentation0.66799196
127MP0001879_abnormal_lymphatic_vessel0.65611933
128MP0003693_abnormal_embryo_hatching0.65037698
129MP0004233_abnormal_muscle_weight0.64774129
130MP0001529_abnormal_vocalization0.64505107
131MP0005058_abnormal_lysosome_morphology0.63156553
132MP0005410_abnormal_fertilization0.62268831
133MP0002697_abnormal_eye_size0.61738413
134MP0003329_amyloid_beta_deposits0.61689620
135MP0003252_abnormal_bile_duct0.60316947
136MP0003943_abnormal_hepatobiliary_system0.59729927
137MP0005083_abnormal_biliary_tract0.59187213
138MP0002095_abnormal_skin_pigmentation0.58384349
139MP0000631_abnormal_neuroendocrine_gland0.56994201
140MP0005266_abnormal_metabolism0.56969929
141MP0010030_abnormal_orbit_morphology0.56557945
142MP0001944_abnormal_pancreas_morphology0.56024543
143MP0003453_abnormal_keratinocyte_physiol0.55408112
144MP0005319_abnormal_enzyme/_coenzyme0.55318172
145MP0005394_taste/olfaction_phenotype0.55239592
146MP0004215_abnormal_myocardial_fiber0.53549812
147MP0000613_abnormal_salivary_gland0.52806501
148MP0005584_abnormal_enzyme/coenzyme_acti0.52792795
149MP0010386_abnormal_urinary_bladder0.50933506
150MP0000049_abnormal_middle_ear0.50565748
151MP0005187_abnormal_penis_morphology0.49650778
152MP0005025_abnormal_response_to0.49326863
153MP0004858_abnormal_nervous_system0.49058918
154MP0000609_abnormal_liver_physiology0.48106195
155MP0005376_homeostasis/metabolism_phenot0.47297284
156MP0008469_abnormal_protein_level0.47132666
157MP0001845_abnormal_inflammatory_respons0.46869462
158MP0003879_abnormal_hair_cell0.46517248
159MP0000604_amyloidosis0.46333058
160MP0005330_cardiomyopathy0.45520772
161MP0002736_abnormal_nociception_after0.45436471
162MP0006035_abnormal_mitochondrial_morpho0.44504313
163MP0002089_abnormal_postnatal_growth/wei0.43173263
164MP0003283_abnormal_digestive_organ0.43078137
165MP0001756_abnormal_urination0.41473479
166MP0002086_abnormal_extraembryonic_tissu0.41430358
167MP0003656_abnormal_erythrocyte_physiolo0.38114735
168MP0002118_abnormal_lipid_homeostasis0.37655296
169MP0002078_abnormal_glucose_homeostasis0.37379635
170MP0009642_abnormal_blood_homeostasis0.37095985
171MP0005220_abnormal_exocrine_pancreas0.33629579
172MP0004510_myositis0.33326842
173MP0000598_abnormal_liver_morphology0.33287711
174MP0003953_abnormal_hormone_level0.32347444
175MP0001730_embryonic_growth_arrest0.31996754
176MP0005164_abnormal_response_to0.31842857
177MP0003221_abnormal_cardiomyocyte_apopto0.30212329

Predicted human phenotypes

RankGene SetZ-score
1Ventricular fibrillation (HP:0001663)9.77932805
2Posterior subcapsular cataract (HP:0007787)9.52031793
3Congenital sensorineural hearing impairment (HP:0008527)8.03333876
4Chorioretinal atrophy (HP:0000533)7.10849947
5Late onset (HP:0003584)6.80402809
6Ketoacidosis (HP:0001993)6.67662672
7Subcapsular cataract (HP:0000523)5.29985542
8Abnormality of the pancreatic islet cells (HP:0006476)5.12919069
9Abnormality of endocrine pancreas physiology (HP:0012093)5.12919069
10Stenosis of the external auditory canal (HP:0000402)4.48700281
11Ketosis (HP:0001946)4.47263068
12Abnormality of cells of the erythroid lineage (HP:0012130)4.19572742
13Reticulocytopenia (HP:0001896)4.14289424
14Ileus (HP:0002595)3.76827231
15Abnormal number of erythroid precursors (HP:0012131)3.72773956
16Abdominal distention (HP:0003270)3.71707733
17Syncope (HP:0001279)3.70659871
18Micronodular cirrhosis (HP:0001413)3.66036795
19Osteomalacia (HP:0002749)3.53621497
20Carpal bone hypoplasia (HP:0001498)3.49277452
21Prolonged QT interval (HP:0001657)3.47227274
22Insulin resistance (HP:0000855)3.40734454
23Hyperammonemia (HP:0001987)3.22804719
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22665986
25Male infertility (HP:0003251)3.19478479
26Microvesicular hepatic steatosis (HP:0001414)3.18240392
27Hepatic necrosis (HP:0002605)3.16398753
28Thin bony cortex (HP:0002753)3.16373134
29Birth length less than 3rd percentile (HP:0003561)3.16204728
30Abnormal EKG (HP:0003115)3.16122891
31Ventricular arrhythmia (HP:0004308)3.14998420
32Facial cleft (HP:0002006)3.12097277
33Hepatocellular necrosis (HP:0001404)3.10107160
34Short tibia (HP:0005736)3.05295308
35Abnormality of aromatic amino acid family metabolism (HP:0004338)3.03672027
36Polar cataract (HP:0010696)2.98545002
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97044262
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97044262
39Chromsome breakage (HP:0040012)2.95996626
40Horseshoe kidney (HP:0000085)2.91654209
41Aplasia/hypoplasia of the uterus (HP:0008684)2.89482926
42Villous atrophy (HP:0011473)2.88859908
43Abnormality of small intestinal villus morphology (HP:0011472)2.88859908
44Multifactorial inheritance (HP:0001426)2.88047352
45Hypoplasia of the uterus (HP:0000013)2.85513060
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.82911718
47Esophageal varix (HP:0002040)2.82890129
48Increased muscle lipid content (HP:0009058)2.80124440
49Ankyloglossia (HP:0010296)2.78597544
50Macrocytic anemia (HP:0001972)2.74995001
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.74902397
52Abnormality of the renal collecting system (HP:0004742)2.73572795
53Bone cyst (HP:0012062)2.71187617
54Abnormal umbilical cord blood vessels (HP:0011403)2.68983539
55Single umbilical artery (HP:0001195)2.68983539
56Abnormality of the fetal cardiovascular system (HP:0010948)2.68983539
57Ragged-red muscle fibers (HP:0003200)2.67560224
58Growth hormone excess (HP:0000845)2.67117561
59Conjunctival hamartoma (HP:0100780)2.65766725
60Pheochromocytoma (HP:0002666)2.64289598
61Absent radius (HP:0003974)2.62049946
62Trismus (HP:0000211)2.60562908
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.60327155
64Shoulder girdle muscle weakness (HP:0003547)2.58037109
65Absent thumb (HP:0009777)2.56350459
66Reduced antithrombin III activity (HP:0001976)2.52286667
67Cerebral hypomyelination (HP:0006808)2.51411554
68Meckel diverticulum (HP:0002245)2.49572134
69Abnormal lung lobation (HP:0002101)2.47119346
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46646039
71Premature ovarian failure (HP:0008209)2.45298105
72Absent forearm bone (HP:0003953)2.44188495
73Aplasia involving forearm bones (HP:0009822)2.44188495
74Severe visual impairment (HP:0001141)2.43926404
75Progressive macrocephaly (HP:0004481)2.43712339
76Menstrual irregularities (HP:0000858)2.42047868
77Increased hepatocellular lipid droplets (HP:0006565)2.41527327
78Agnosia (HP:0010524)2.40850231
79Pustule (HP:0200039)2.39205986
80Increased intramyocellular lipid droplets (HP:0012240)2.38052111
81Rectal fistula (HP:0100590)2.36581575
82Rectovaginal fistula (HP:0000143)2.36581575
83Abnormal mitochondria in muscle tissue (HP:0008316)2.34077999
84Abnormality of the ileum (HP:0001549)2.34040674
85Ependymoma (HP:0002888)2.33341092
86Hypergonadotropic hypogonadism (HP:0000815)2.33125473
87Abnormality of the preputium (HP:0100587)2.33058949
88Mitochondrial inheritance (HP:0001427)2.32434266
89Symptomatic seizures (HP:0011145)2.32127892
90Acute encephalopathy (HP:0006846)2.31245592
91Neoplasm of the rectum (HP:0100743)2.28253227
92Fused cervical vertebrae (HP:0002949)2.26413385
93Vaginal fistula (HP:0004320)2.26002914
94Testicular atrophy (HP:0000029)2.24167908
95Hypoglycemic coma (HP:0001325)2.24130998
96Neuroendocrine neoplasm (HP:0100634)2.22975639
97Lipid accumulation in hepatocytes (HP:0006561)2.21084616
98Type I transferrin isoform profile (HP:0003642)2.15960531
99Lethargy (HP:0001254)2.14957795
100Neoplasm of the small intestine (HP:0100833)2.13663018
101Pallor (HP:0000980)2.13641000
102CNS hypomyelination (HP:0003429)2.13197796
103Confusion (HP:0001289)2.11826827
104Renal Fanconi syndrome (HP:0001994)2.11375127
105Angiofibromas (HP:0010615)2.11194306
106Adenoma sebaceum (HP:0009720)2.11194306
107Ectopic kidney (HP:0000086)2.08307412
108Cerebral edema (HP:0002181)2.07083805
109Emotional lability (HP:0000712)2.06586105
110Cleft eyelid (HP:0000625)2.06217780
111Abnormality of the costochondral junction (HP:0000919)2.05658416
112Male pseudohermaphroditism (HP:0000037)2.05274024
113Ureteral duplication (HP:0000073)2.04863460
114Deep venous thrombosis (HP:0002625)2.04500997
115Abnormality of the vitamin B12 metabolism (HP:0004341)2.04286896
116Increased CSF lactate (HP:0002490)2.04077481
117Abnormality of oral frenula (HP:0000190)2.02528387
118Patent foramen ovale (HP:0001655)2.00114882
119Abnormality of vitamin B metabolism (HP:0004340)1.99630720
120Oral leukoplakia (HP:0002745)1.99141760
121Abnormality of the septum pellucidum (HP:0007375)1.98348608
122Median cleft lip (HP:0000161)1.97757579
123Delayed epiphyseal ossification (HP:0002663)1.97652204
124Cerebral hemorrhage (HP:0001342)1.97563212
125Rough bone trabeculation (HP:0100670)1.97151369
126Pendular nystagmus (HP:0012043)1.93843824
127Sensory axonal neuropathy (HP:0003390)1.92817813
128Wide cranial sutures (HP:0010537)1.91145957
129Premature loss of primary teeth (HP:0006323)1.90677306
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89916901
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.89916901
132Intrahepatic cholestasis (HP:0001406)1.89563051
133Abnormality of the labia minora (HP:0012880)1.89475800
134Right ventricular cardiomyopathy (HP:0011663)1.89435478
135Abnormality of vitamin metabolism (HP:0100508)1.89161109
136Abnormality of the vocal cords (HP:0008777)1.88860299
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.87832083
138Proximal tubulopathy (HP:0000114)1.85493804
139Duplication of thumb phalanx (HP:0009942)1.85080622
140Abnormality of cochlea (HP:0000375)1.84923007
141Respiratory failure (HP:0002878)1.84841201
142Gout (HP:0001997)1.84506127
143Hyperglycinuria (HP:0003108)1.84466779
144Triphalangeal thumb (HP:0001199)1.84429834
145Supernumerary spleens (HP:0009799)1.84329222
146Hyperparathyroidism (HP:0000843)1.83307082
147Acute necrotizing encephalopathy (HP:0006965)1.83037645
148Biliary tract neoplasm (HP:0100574)1.82680460
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82641804
150Hypoplasia of the radius (HP:0002984)1.82602951
151Generalized aminoaciduria (HP:0002909)1.82573633
152Absent septum pellucidum (HP:0001331)1.82423048
153Abnormality of DNA repair (HP:0003254)1.82272001
154Periauricular skin pits (HP:0100277)1.81728721
155Preauricular pit (HP:0004467)1.81728721
156Palpitations (HP:0001962)1.80682986
157Intestinal polyposis (HP:0200008)1.75486727
158CNS demyelination (HP:0007305)1.74637113
159Hypobetalipoproteinemia (HP:0003563)1.74029369
160Increased serum lactate (HP:0002151)1.73817400
161Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73626308
162Multiple enchondromatosis (HP:0005701)1.72874238
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70367358
164Dicarboxylic aciduria (HP:0003215)1.70367358
165Microretrognathia (HP:0000308)1.67811471
166Lactic acidosis (HP:0003128)1.66849896
167Myoglobinuria (HP:0002913)1.66721564
168Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65236914
169Progressive muscle weakness (HP:0003323)1.64905616
170Spastic diplegia (HP:0001264)1.64161331
171Increased serum pyruvate (HP:0003542)1.64065131
172Abnormality of glycolysis (HP:0004366)1.64065131
173Irritability (HP:0000737)1.62976580
174Hyperinsulinemic hypoglycemia (HP:0000825)1.59847330
175Supraventricular tachycardia (HP:0004755)1.59633917
176Protuberant abdomen (HP:0001538)1.59584268
177Neoplasm of the adrenal gland (HP:0100631)1.59442366
178Uterine neoplasm (HP:0010784)1.59227161
179Glycosuria (HP:0003076)1.57601053
180Abnormality of urine glucose concentration (HP:0011016)1.57601053
181Intestinal polyp (HP:0005266)1.57553618
182Atrial fibrillation (HP:0005110)1.55636215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K65.10977516
2MAP2K24.96739327
3ACVR1B3.59701869
4SRPK13.38997600
5STK163.22702934
6SCYL22.81820632
7NME22.79996157
8PKN22.78966556
9LMTK22.78312351
10MAPK152.74987840
11PLK42.64794317
12BCKDK2.62768753
13TRIB32.58058617
14PNCK2.53871241
15CDC72.44049707
16NME12.37103974
17BRSK12.36051505
18PLK12.26112923
19VRK22.24298410
20MAP3K22.20190227
21BRSK22.12426423
22BUB12.09011332
23DAPK22.08262838
24PIM22.01861686
25GRK61.96243241
26MAP3K101.88961241
27MST1R1.84812955
28ERN11.82392223
29PTK21.79913683
30CAMK2B1.73373007
31RPS6KB21.70104362
32AURKA1.67489262
33PAK41.66695526
34PTK61.65077964
35MAP3K121.63401052
36MST41.59893530
37ZAK1.57931672
38MAP2K11.57684831
39WEE11.55509988
40PRKG21.53139513
41PLK31.51111934
42BLK1.48680799
43BMX1.43740804
44MAP3K31.39402299
45MAP3K111.38775303
46CAMK2D1.36776446
47CAMK2G1.36348938
48PDK21.35367827
49KSR21.34725592
50LATS21.34507423
51CHEK21.26322155
52LIMK11.22876612
53VRK11.20543232
54WNK41.18730411
55TESK11.17992539
56STK391.10238932
57EPHA41.09322536
58CHEK11.08497317
59CDK71.07242849
60CDK81.05281685
61NTRK10.98573349
62FGFR40.92134495
63STK240.91234035
64DAPK10.91108947
65STK30.89580213
66EIF2AK30.87402622
67STK40.86517620
68CSNK2A10.84416646
69CSNK2A20.84368177
70PBK0.82796415
71RAF10.82114814
72MAP4K10.81397808
73DAPK30.81122031
74RIPK10.79655684
75ATR0.79223712
76ERBB20.77701160
77CDK190.77078029
78MET0.76172654
79DYRK30.76097733
80GRK10.76047216
81LRRK20.74406317
82DYRK1B0.73936774
83MYLK0.72653896
84CAMKK10.71864777
85TAF10.71586444
86NTRK30.71504644
87TRIM280.70716140
88CDK150.70672459
89BRAF0.70278499
90ATM0.68556596
91MAP3K80.68363197
92PAK10.68177728
93ILK0.67599584
94KDR0.65247530
95CDK180.65093343
96STK38L0.64984862
97NEK60.64310089
98CSNK1G20.64294594
99TTK0.63960572
100CDK11A0.63759301
101NEK10.63348356
102DYRK20.63198990
103NUAK10.62255971
104MAPK110.61990411
105MAP3K90.61859898
106ERBB40.60824032
107CSNK1G10.59524223
108PRKCQ0.59118810
109PASK0.58579893
110CDK140.57563266
111TBK10.57519704
112RIPK40.55950139
113GRK50.55742468
114PRKCD0.55641919
115BMPR1B0.55418466
116PIM10.54755862
117CDK90.54514374
118MAPK40.54222996
119MAP3K10.54065658
120STK100.53967608
121TAOK10.53909623
122OXSR10.51707026
123SIK10.50644338
124WNK10.49886841
125PDPK10.48982777
126CDK20.48094995
127ABL20.46708995
128CDK50.45975512
129PRKCI0.45876482
130TAOK20.45100165
131CDK40.45033446
132CDK10.45019932
133PKN10.44772916
134PAK30.44229848
135FER0.43682017
136WNK30.43188500
137MATK0.43095460
138AKT20.42358452
139CAMK2A0.41962724
140RPS6KA10.41701747
141TSSK60.40752666
142CSNK1G30.40547795
143ARAF0.38345729
144SRC0.38224528
145PRKCA0.36839144
146TGFBR10.36009309
147PINK10.35981761
148UHMK10.35544364
149EPHB10.34082735
150ROCK20.33840046
151EPHB20.33417296
152CSNK1E0.31298129
153CSNK1A10.31054535
154TLK10.30260002
155TESK20.29763902
156AURKB0.29701839
157PRKACB0.29554463
158KSR10.28274469
159PAK20.26967449
160NEK20.26726850
161PDK10.26669546
162FGFR10.26151820
163CLK10.25148709
164PRKG10.22345874

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.86576592
2Ribosome_Homo sapiens_hsa030105.01611518
3Pentose and glucuronate interconversions_Homo sapiens_hsa000404.28969605
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.09190409
5Histidine metabolism_Homo sapiens_hsa003403.84928428
6RNA polymerase_Homo sapiens_hsa030203.71518298
7Arginine and proline metabolism_Homo sapiens_hsa003303.36446033
8Nitrogen metabolism_Homo sapiens_hsa009103.27610440
9Fatty acid degradation_Homo sapiens_hsa000713.22574247
10Maturity onset diabetes of the young_Homo sapiens_hsa049503.21084856
11Pyruvate metabolism_Homo sapiens_hsa006203.04783907
12Tryptophan metabolism_Homo sapiens_hsa003803.02663285
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77496102
14Base excision repair_Homo sapiens_hsa034102.69218155
15beta-Alanine metabolism_Homo sapiens_hsa004102.60958606
16RNA transport_Homo sapiens_hsa030132.57658523
17Basal transcription factors_Homo sapiens_hsa030222.56390114
18Regulation of autophagy_Homo sapiens_hsa041402.43090788
19Homologous recombination_Homo sapiens_hsa034402.38395227
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34764880
21Cyanoamino acid metabolism_Homo sapiens_hsa004602.22359930
22Pyrimidine metabolism_Homo sapiens_hsa002402.13018361
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.12353423
24Spliceosome_Homo sapiens_hsa030402.09395898
25Oxidative phosphorylation_Homo sapiens_hsa001902.08018554
26Parkinsons disease_Homo sapiens_hsa050122.01920480
27Nucleotide excision repair_Homo sapiens_hsa034202.00153160
28Fanconi anemia pathway_Homo sapiens_hsa034601.98536178
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96298112
30Cell cycle_Homo sapiens_hsa041101.95633326
31RNA degradation_Homo sapiens_hsa030181.60590195
32Arginine biosynthesis_Homo sapiens_hsa002201.59839928
33mRNA surveillance pathway_Homo sapiens_hsa030151.59057791
34Glycerolipid metabolism_Homo sapiens_hsa005611.53268453
35Fructose and mannose metabolism_Homo sapiens_hsa000511.52446223
36Protein export_Homo sapiens_hsa030601.51918899
37Glutathione metabolism_Homo sapiens_hsa004801.47140541
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43881918
39Alzheimers disease_Homo sapiens_hsa050101.42909476
40Carbon metabolism_Homo sapiens_hsa012001.42635930
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33044696
42Non-homologous end-joining_Homo sapiens_hsa034501.32661339
43Biosynthesis of amino acids_Homo sapiens_hsa012301.30216043
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27847512
45Purine metabolism_Homo sapiens_hsa002301.23486455
46Oocyte meiosis_Homo sapiens_hsa041141.20526968
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16752254
48p53 signaling pathway_Homo sapiens_hsa041151.16300513
49Steroid biosynthesis_Homo sapiens_hsa001001.15316611
50Lysine degradation_Homo sapiens_hsa003101.14881970
51Pentose phosphate pathway_Homo sapiens_hsa000301.13796886
52Huntingtons disease_Homo sapiens_hsa050161.09584282
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01959859
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.99045651
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97241101
56Cardiac muscle contraction_Homo sapiens_hsa042600.93509920
57Fat digestion and absorption_Homo sapiens_hsa049750.89323520
58Tight junction_Homo sapiens_hsa045300.87680632
59Propanoate metabolism_Homo sapiens_hsa006400.86965309
60Butanoate metabolism_Homo sapiens_hsa006500.86642766
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84257747
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.83166017
63Hepatitis C_Homo sapiens_hsa051600.82570804
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81146523
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80286557
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80264645
67Vibrio cholerae infection_Homo sapiens_hsa051100.79179478
68Sulfur metabolism_Homo sapiens_hsa009200.75808564
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75752675
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75090836
71Fatty acid metabolism_Homo sapiens_hsa012120.74428045
72Bladder cancer_Homo sapiens_hsa052190.73668316
73Fatty acid elongation_Homo sapiens_hsa000620.73249074
74Galactose metabolism_Homo sapiens_hsa000520.72095956
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70825819
76One carbon pool by folate_Homo sapiens_hsa006700.67547242
77Folate biosynthesis_Homo sapiens_hsa007900.65201435
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63673407
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62635072
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59551970
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.59300702
82Vitamin B6 metabolism_Homo sapiens_hsa007500.59070597
83Arachidonic acid metabolism_Homo sapiens_hsa005900.57441658
84Gastric acid secretion_Homo sapiens_hsa049710.57058278
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55176532
86Vitamin digestion and absorption_Homo sapiens_hsa049770.53994207
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52428241
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52313705
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51549106
90Bile secretion_Homo sapiens_hsa049760.50884710
91Pertussis_Homo sapiens_hsa051330.49895024
92Protein digestion and absorption_Homo sapiens_hsa049740.49554788
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.48223526
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47087417
95Dorso-ventral axis formation_Homo sapiens_hsa043200.47063167
96Salmonella infection_Homo sapiens_hsa051320.46419067
97Sulfur relay system_Homo sapiens_hsa041220.46175674
98Peroxisome_Homo sapiens_hsa041460.44625982
99Thyroid hormone synthesis_Homo sapiens_hsa049180.44045124
100Metabolic pathways_Homo sapiens_hsa011000.43345321
101VEGF signaling pathway_Homo sapiens_hsa043700.41856406
102Epstein-Barr virus infection_Homo sapiens_hsa051690.41154620
103N-Glycan biosynthesis_Homo sapiens_hsa005100.38104575
104Chemical carcinogenesis_Homo sapiens_hsa052040.37965403
105TGF-beta signaling pathway_Homo sapiens_hsa043500.37392628
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36423949
107PPAR signaling pathway_Homo sapiens_hsa033200.35992609
108Proteasome_Homo sapiens_hsa030500.35058841
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33905580
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32400666
111Leishmaniasis_Homo sapiens_hsa051400.32220024
112Pancreatic secretion_Homo sapiens_hsa049720.32051284
113Selenocompound metabolism_Homo sapiens_hsa004500.30987930
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30910279
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30909368
116DNA replication_Homo sapiens_hsa030300.30422758
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30296201
118GnRH signaling pathway_Homo sapiens_hsa049120.30160374
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28099906
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27341542
121Cocaine addiction_Homo sapiens_hsa050300.26545124
122Wnt signaling pathway_Homo sapiens_hsa043100.25114363
123Amphetamine addiction_Homo sapiens_hsa050310.25049483
124Collecting duct acid secretion_Homo sapiens_hsa049660.24319389
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22665534
126Mineral absorption_Homo sapiens_hsa049780.21170024
127Hedgehog signaling pathway_Homo sapiens_hsa043400.20991421
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20786456
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20232424
130Shigellosis_Homo sapiens_hsa051310.19146929
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19093661
132Dopaminergic synapse_Homo sapiens_hsa047280.18963016
133Thyroid cancer_Homo sapiens_hsa052160.18671271
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16898819
135Retinol metabolism_Homo sapiens_hsa008300.16895523
136Tyrosine metabolism_Homo sapiens_hsa003500.16212604
137Caffeine metabolism_Homo sapiens_hsa002320.14959176
138Cholinergic synapse_Homo sapiens_hsa047250.14727417
139Other glycan degradation_Homo sapiens_hsa005110.13781941
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12771930
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11056008
142Fatty acid biosynthesis_Homo sapiens_hsa000610.10500575
143Phenylalanine metabolism_Homo sapiens_hsa003600.10499945
144Starch and sucrose metabolism_Homo sapiens_hsa005000.10369058
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09677903
146Hippo signaling pathway_Homo sapiens_hsa043900.09298057
147Mismatch repair_Homo sapiens_hsa034300.08925548
148Estrogen signaling pathway_Homo sapiens_hsa049150.08328726
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06523543
150Long-term potentiation_Homo sapiens_hsa047200.06486426
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.04968684

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