GIPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of nitric-oxide synthase activity (GO:0051001)6.75844639
2regulation of metalloenzyme activity (GO:0048552)5.98854703
3adenosine receptor signaling pathway (GO:0001973)5.95678889
4angiogenesis involved in wound healing (GO:0060055)5.77873467
5membrane raft organization (GO:0031579)5.57946185
6thrombin receptor signaling pathway (GO:0070493)5.23557448
7positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.94542680
8heart trabecula formation (GO:0060347)4.78253332
9cardiac myofibril assembly (GO:0055003)4.76768307
10sarcomere organization (GO:0045214)4.64722892
11substrate-dependent cell migration (GO:0006929)4.60439887
12negative regulation of monooxygenase activity (GO:0032769)4.36346366
13positive regulation of odontogenesis (GO:0042482)4.35660052
14neutrophil activation involved in immune response (GO:0002283)4.30535722
15regulation of the force of heart contraction (GO:0002026)4.27712836
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.25313043
17myofibril assembly (GO:0030239)4.16917565
18positive regulation of protein kinase C signaling (GO:0090037)4.11330194
19positive regulation of DNA-templated transcription, initiation (GO:2000144)4.08280178
20megakaryocyte development (GO:0035855)3.93735940
21mannose metabolic process (GO:0006013)3.89738280
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.87643297
23regulation of actin filament-based movement (GO:1903115)3.86626647
24vascular endothelial growth factor signaling pathway (GO:0038084)3.80713533
25fatty acid transmembrane transport (GO:1902001)3.69834819
26negative regulation of erythrocyte differentiation (GO:0045647)3.67794834
27positive regulation of histone deacetylation (GO:0031065)3.66237450
28membrane assembly (GO:0071709)3.63832824
29negative regulation of potassium ion transmembrane transport (GO:1901380)3.61290906
30regulation of cholesterol storage (GO:0010885)3.58292523
31positive regulation of gamma-delta T cell activation (GO:0046645)3.57838579
32cardiac muscle contraction (GO:0060048)3.57047026
33purinergic nucleotide receptor signaling pathway (GO:0035590)3.56750827
342-oxoglutarate metabolic process (GO:0006103)3.53000379
35G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.52704176
36plasma membrane repair (GO:0001778)3.50322161
37trabecula formation (GO:0060343)3.46654329
38platelet aggregation (GO:0070527)3.46045727
39negative regulation of JAK-STAT cascade (GO:0046426)3.43794877
40pinocytosis (GO:0006907)3.41472757
41regulation of platelet aggregation (GO:0090330)3.41221077
42regulation of integrin activation (GO:0033623)3.40028739
43carnitine shuttle (GO:0006853)3.33909983
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.31016973
45positive regulation of B cell differentiation (GO:0045579)3.30333514
46cardiac muscle cell proliferation (GO:0060038)3.30028695
47UV protection (GO:0009650)3.28970291
48regulation of relaxation of muscle (GO:1901077)3.27895063
49hypotonic response (GO:0006971)3.27034739
50hyaluronan catabolic process (GO:0030214)3.26993914
51regulation of cardiac muscle cell contraction (GO:0086004)3.26342432
52purinergic receptor signaling pathway (GO:0035587)3.25485470
53positive regulation of vasculogenesis (GO:2001214)3.24013677
54regulation of platelet activation (GO:0010543)3.23224021
55cellular response to thyroid hormone stimulus (GO:0097067)3.23197657
56valine metabolic process (GO:0006573)3.22800072
57regulation of gamma-delta T cell activation (GO:0046643)3.21117486
58platelet formation (GO:0030220)3.18608396
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15102754
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15102754
61Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14188614
62lymph vessel development (GO:0001945)3.13972662
63response to ischemia (GO:0002931)3.12744777
64cellular extravasation (GO:0045123)3.10484300
65negative regulation of homotypic cell-cell adhesion (GO:0034111)3.08929084
66antigen processing and presentation of endogenous antigen (GO:0019883)3.07144445
67negative regulation of endothelial cell proliferation (GO:0001937)3.06890944
68regulation of gamma-delta T cell differentiation (GO:0045586)3.05333369
69negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.05173317
70positive regulation of endothelial cell differentiation (GO:0045603)3.03978141
71creatine metabolic process (GO:0006600)3.03667865
72cardiac muscle cell development (GO:0055013)3.03630354
73regulation of fatty acid beta-oxidation (GO:0031998)3.03005755
74positive regulation of mast cell activation (GO:0033005)3.01563860
75retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00940444
76natural killer cell differentiation (GO:0001779)3.00541626
77actomyosin structure organization (GO:0031032)3.00526070
78negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.00454517
79regulation of fatty acid oxidation (GO:0046320)3.00395040
80definitive hemopoiesis (GO:0060216)2.98856035
81growth hormone receptor signaling pathway (GO:0060396)2.98763927
82positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.96773566
83negative regulation of blood vessel endothelial cell migration (GO:0043537)2.95198515
84lysine metabolic process (GO:0006553)2.93169446
85lysine catabolic process (GO:0006554)2.93169446
86regulation of mast cell degranulation (GO:0043304)2.91547289
87regulation of early endosome to late endosome transport (GO:2000641)2.90795028
88cardiac cell development (GO:0055006)2.89926454
89cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.88393922
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.87969699
91ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.87908188
92positive regulation of triglyceride biosynthetic process (GO:0010867)2.87904718
93regulation of skeletal muscle contraction (GO:0014819)2.87832578
94regulation of cholesterol homeostasis (GO:2000188)2.87486812
95regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.87169291
96granulocyte differentiation (GO:0030851)2.87154060
97triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.85280083
98basement membrane organization (GO:0071711)2.84676060
99positive regulation of fatty acid beta-oxidation (GO:0032000)2.81968133
100negative regulation of vascular permeability (GO:0043116)2.81492088
101stress fiber assembly (GO:0043149)2.81366043
102positive regulation of receptor recycling (GO:0001921)2.80588641
103lipoxygenase pathway (GO:0019372)2.80131890
104response to muramyl dipeptide (GO:0032495)2.79240236
105tricarboxylic acid cycle (GO:0006099)2.79074449
106regulation of erythrocyte differentiation (GO:0045646)2.77510218
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76846340
108germinal center formation (GO:0002467)2.76320007
109glomerular basement membrane development (GO:0032836)2.75109990
110actin-myosin filament sliding (GO:0033275)2.74998168
111muscle filament sliding (GO:0030049)2.74998168
112regulation of endothelial cell differentiation (GO:0045601)2.74460534
113endothelial cell chemotaxis (GO:0035767)2.74213493
114positive regulation of systemic arterial blood pressure (GO:0003084)2.74093328
115mammary gland development (GO:0030879)2.73607893
116negative regulation of anoikis (GO:2000811)2.71456598
117striated muscle contraction (GO:0006941)2.71169025
118bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70077325
119response to thyroid hormone (GO:0097066)2.69704183
120cardiac muscle tissue morphogenesis (GO:0055008)2.68901885
121regulation of leukocyte degranulation (GO:0043300)2.68306085
122peptidyl-glutamic acid carboxylation (GO:0017187)2.68036328
123protein carboxylation (GO:0018214)2.68036328
124negative regulation of platelet activation (GO:0010544)2.67909713
125positive thymic T cell selection (GO:0045059)2.67027436
126poly(A)+ mRNA export from nucleus (GO:0016973)2.66886172
127alpha-linolenic acid metabolic process (GO:0036109)2.65732632
128blood coagulation, intrinsic pathway (GO:0007597)2.65245437
129melanin biosynthetic process (GO:0042438)2.65125146
130regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63918901
131negative regulation of oxidoreductase activity (GO:0051354)2.63853361
132negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.62931756
133response to peptidoglycan (GO:0032494)2.62390078
134ventricular cardiac muscle cell action potential (GO:0086005)2.61952607
135cardiolipin metabolic process (GO:0032048)2.61782705
136protein localization to endosome (GO:0036010)2.61631442
137leukocyte degranulation (GO:0043299)2.60857093
138regulation of mast cell activation involved in immune response (GO:0033006)2.59214634
139platelet activation (GO:0030168)2.58447012
140granulocyte activation (GO:0036230)2.56718965
141negative regulation of stress fiber assembly (GO:0051497)2.56713008
142establishment of endothelial barrier (GO:0061028)2.56014992
143regulation of T-helper 2 cell differentiation (GO:0045628)2.55962501
144endothelium development (GO:0003158)2.53679947
145skin morphogenesis (GO:0043589)2.52591255
146morphogenesis of an endothelium (GO:0003159)2.52458004
147endothelial tube morphogenesis (GO:0061154)2.52458004
148positive regulation of myotube differentiation (GO:0010831)2.52289969
149negative regulation of granulocyte differentiation (GO:0030853)2.51696982
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51682623
151negative regulation of T-helper cell differentiation (GO:0045623)2.51682623
152regulation of integrin-mediated signaling pathway (GO:2001044)2.51568668
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51014909
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50967143
155cardiac muscle hypertrophy (GO:0003300)2.50793643
156blood vessel maturation (GO:0001955)2.50206528
157cellular response to growth hormone stimulus (GO:0071378)2.49817170
158vasculogenesis (GO:0001570)2.49568143
159muscle atrophy (GO:0014889)2.49397231
160positive regulation of fatty acid oxidation (GO:0046321)2.49347090
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49289486
162tricarboxylic acid metabolic process (GO:0072350)2.49266374
163neutrophil activation (GO:0042119)2.47980097
164adherens junction assembly (GO:0034333)2.47918480
165regulation of T-helper 1 cell differentiation (GO:0045625)2.47487564
166leukocyte migration involved in inflammatory response (GO:0002523)2.47281377
167melanin metabolic process (GO:0006582)2.46804296
168oxaloacetate metabolic process (GO:0006107)2.46536832
169cell-substrate adherens junction assembly (GO:0007045)2.45970118
170focal adhesion assembly (GO:0048041)2.45970118
171venous blood vessel morphogenesis (GO:0048845)2.45732574
172regulation of anoikis (GO:2000209)2.45389075
173striated muscle cell proliferation (GO:0014855)2.45334596
174GDP-mannose metabolic process (GO:0019673)2.43280872
175heart valve formation (GO:0003188)2.43178992
176regulation of vasculogenesis (GO:2001212)2.43010200
177negative regulation of glycoprotein biosynthetic process (GO:0010561)2.41798548
178NIK/NF-kappaB signaling (GO:0038061)2.41615702
179myeloid cell development (GO:0061515)2.41356474
180regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.41208557
181homotypic cell-cell adhesion (GO:0034109)2.40161827
182platelet degranulation (GO:0002576)2.39858247
183myeloid cell activation involved in immune response (GO:0002275)2.37682109
184modulation by virus of host process (GO:0019054)2.35039448
185response to laminar fluid shear stress (GO:0034616)2.33696974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.78465942
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.42665890
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18450895
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.79498945
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62464781
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53594947
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41929247
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.38528897
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37189997
10ZNF263_19887448_ChIP-Seq_K562_Human2.35143926
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31550987
12MYC_22102868_ChIP-Seq_BL_Human2.30412781
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.26274467
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.26274467
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.21763969
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20323680
17KDM2B_26808549_Chip-Seq_DND41_Human2.14849757
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14782610
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11372149
20MAF_26560356_Chip-Seq_TH2_Human2.02763997
21P68_20966046_ChIP-Seq_HELA_Human2.00445965
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.99465924
23TCF7_22412390_ChIP-Seq_EML_Mouse1.94589456
24CLOCK_20551151_ChIP-Seq_293T_Human1.94461655
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.94335725
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.93179621
27VDR_21846776_ChIP-Seq_THP-1_Human1.91987679
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.90730527
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.89966065
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.89511158
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.88346428
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.87309429
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87066166
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.86729835
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.79174856
36LXR_22292898_ChIP-Seq_THP-1_Human1.77906191
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.77127622
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72210420
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67964497
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67043994
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66963520
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64747009
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.63975502
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63396308
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61146148
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59013149
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57314023
48BCL6_27268052_Chip-Seq_Bcells_Human1.55798195
49MAF_26560356_Chip-Seq_TH1_Human1.55633368
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52066818
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50261105
52GATA1_19941826_ChIP-Seq_K562_Human1.49818368
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49362179
54TP63_17297297_ChIP-ChIP_HaCaT_Human1.49174867
55BCOR_27268052_Chip-Seq_Bcells_Human1.49076474
56RACK7_27058665_Chip-Seq_MCF-7_Human1.48914645
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48724135
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47119350
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43833771
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42542035
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.40884836
62GATA1_22025678_ChIP-Seq_K562_Human1.39768783
63UTX_26944678_Chip-Seq_JUKART_Human1.39331194
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38311005
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.35626600
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.35274727
67SMC4_20622854_ChIP-Seq_HELA_Human1.34951626
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34153958
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33325680
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31596223
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.31511140
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31457018
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30182577
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29926835
75CTCF_21964334_Chip-Seq_Bcells_Human1.28295990
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26786802
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26076055
78SPI1_23547873_ChIP-Seq_NB4_Human1.24874406
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.24570234
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24146289
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.23860388
82MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22940550
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22878247
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22835175
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22630700
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.22248313
87SCL_19346495_ChIP-Seq_HPC-7_Human1.21985637
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.21846831
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.21331798
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20030626
91* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18962237
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18841775
93* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18371461
94IRF8_27001747_Chip-Seq_BMDM_Mouse1.18361630
95KDM2B_26808549_Chip-Seq_K562_Human1.17989045
96E2F1_20622854_ChIP-Seq_HELA_Human1.17897618
97SPI1_23127762_ChIP-Seq_K562_Human1.17155028
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16616169
99CREB1_26743006_Chip-Seq_LNCaP_Human1.16276233
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15951876
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15174575
102PHF8_20622854_ChIP-Seq_HELA_Human1.14830767
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13446319
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12742021
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12658060
106RUNX_20019798_ChIP-Seq_JUKART_Human1.12066554
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11754822
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11545839
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10990671
110GATA2_19941826_ChIP-Seq_K562_Human1.10648568
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09334258
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08970077
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08490761
114* CTCF_26484167_Chip-Seq_Bcells_Mouse1.07626676
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06754068
116FOXA2_19822575_ChIP-Seq_HepG2_Human1.06730597
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06529948
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05516146
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05266363
120EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04757442
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04694816
122MYB_26560356_Chip-Seq_TH1_Human1.04463114
123EGR1_19374776_ChIP-ChIP_THP-1_Human1.04208026
124VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03447640
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03192925
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02936629
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02510206
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02196750
129CTCF_27219007_Chip-Seq_Bcells_Human1.01749137
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01078139
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00614617
132MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99980684
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99585769
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98970271
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98421370
136SA1_27219007_Chip-Seq_Bcells_Human0.97781601
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97392941
138NCOR1_26117541_ChIP-Seq_K562_Human0.96563568
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95356206
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94331518
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.93964757
142VDR_24763502_ChIP-Seq_THP-1_Human0.93105126
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89590785
144ATF3_27146783_Chip-Seq_COLON_Human0.88563170
145DROSHA_22980978_ChIP-Seq_HELA_Human0.88235330
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88046666
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87802517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.87918019
2MP0003191_abnormal_cellular_cholesterol5.74121248
3MP0003705_abnormal_hypodermis_morpholog4.83025193
4MP0009780_abnormal_chondrocyte_physiolo4.68603220
5MP0005464_abnormal_platelet_physiology4.29945675
6MP0003950_abnormal_plasma_membrane4.10492994
7MP0005409_darkened_coat_color3.76615443
8MP0003828_pulmonary_edema3.45903607
9MP0005171_absent_coat_pigmentation3.20921230
10MP0004084_abnormal_cardiac_muscle3.06293400
11MP0010368_abnormal_lymphatic_system3.05008714
12MP0002332_abnormal_exercise_endurance2.81871604
13MP0002837_dystrophic_cardiac_calcinosis2.78369179
14MP0005058_abnormal_lysosome_morphology2.74205970
15MP0003045_fibrosis2.61230941
16MP0006138_congestive_heart_failure2.53831750
17MP0003646_muscle_fatigue2.51556820
18MP0001879_abnormal_lymphatic_vessel2.48853572
19MP0005330_cardiomyopathy2.39309326
20MP0003724_increased_susceptibility_to2.36233332
21MP0000751_myopathy2.34231116
22MP0000465_gastrointestinal_hemorrhage2.24908944
23MP0001853_heart_inflammation2.23525218
24MP0008004_abnormal_stomach_pH2.21252522
25MP0002877_abnormal_melanocyte_morpholog2.11909303
26MP0005174_abnormal_tail_pigmentation2.09322979
27MP0004036_abnormal_muscle_relaxation2.01470921
28MP0003136_yellow_coat_color2.00303238
29MP0004215_abnormal_myocardial_fiber1.95691023
30MP0003436_decreased_susceptibility_to1.94573303
31MP0004130_abnormal_muscle_cell1.90838641
32MP0001544_abnormal_cardiovascular_syste1.84958753
33MP0005385_cardiovascular_system_phenoty1.84958753
34MP0000013_abnormal_adipose_tissue1.84845331
35MP0009840_abnormal_foam_cell1.76864436
36MP0000015_abnormal_ear_pigmentation1.73271848
37MP0004087_abnormal_muscle_fiber1.71295812
38MP0004510_myositis1.68119816
39MP0002972_abnormal_cardiac_muscle1.64681780
40MP0010630_abnormal_cardiac_muscle1.64304842
41MP0009333_abnormal_splenocyte_physiolog1.62191305
42MP0009278_abnormal_bone_marrow1.60853626
43MP0000750_abnormal_muscle_regeneration1.55283741
44MP0005451_abnormal_body_composition1.54450930
45MP0004381_abnormal_hair_follicle1.52387072
46MP0003172_abnormal_lysosome_physiology1.49719479
47MP0004147_increased_porphyrin_level1.46989649
48MP0003453_abnormal_keratinocyte_physiol1.45559848
49MP0001986_abnormal_taste_sensitivity1.44938300
50MP0000003_abnormal_adipose_tissue1.41833599
51MP0001835_abnormal_antigen_presentation1.40031131
52MP0002398_abnormal_bone_marrow1.36965091
53MP0000685_abnormal_immune_system1.36016761
54MP0002148_abnormal_hypersensitivity_rea1.35641289
55MP0004272_abnormal_basement_membrane1.34281232
56MP0002419_abnormal_innate_immunity1.32117812
57MP0004484_altered_response_of1.28935977
58MP0005620_abnormal_muscle_contractility1.28146954
59MP0005165_increased_susceptibility_to1.27391057
60MP0010352_gastrointestinal_tract_polyps1.27321332
61MP0003091_abnormal_cell_migration1.27301197
62MP0005167_abnormal_blood-brain_barrier1.26339145
63MP0001661_extended_life_span1.26050393
64MP0003300_gastrointestinal_ulcer1.25655383
65MP0003195_calcinosis1.25635387
66MP0000767_abnormal_smooth_muscle1.24948119
67MP0008775_abnormal_heart_ventricle1.23476261
68MP0003879_abnormal_hair_cell1.20716125
69MP0005000_abnormal_immune_tolerance1.20248390
70MP0002106_abnormal_muscle_physiology1.20124150
71MP0005025_abnormal_response_to1.17158626
72MP0005670_abnormal_white_adipose1.16782062
73MP0003279_aneurysm1.16551553
74MP0005083_abnormal_biliary_tract1.15080178
75MP0002723_abnormal_immune_serum1.14320689
76MP0003448_altered_tumor_morphology1.13885730
77MP0003221_abnormal_cardiomyocyte_apopto1.12528870
78MP0005623_abnormal_meninges_morphology1.11643692
79MP0002168_other_aberrant_phenotype1.10041408
80MP0002429_abnormal_blood_cell1.09716232
81MP0003763_abnormal_thymus_physiology1.09471597
82MP0002420_abnormal_adaptive_immunity1.07497423
83MP0001819_abnormal_immune_cell1.07411031
84MP0004185_abnormal_adipocyte_glucose1.06865581
85MP0001851_eye_inflammation1.06510488
86MP0002722_abnormal_immune_system1.04502936
87MP0005671_abnormal_response_to1.03773641
88MP0003567_abnormal_fetal_cardiomyocyte1.03717875
89MP0003566_abnormal_cell_adhesion1.03667601
90MP0001188_hyperpigmentation1.03515649
91MP0002396_abnormal_hematopoietic_system1.03225183
92MP0005387_immune_system_phenotype1.03140856
93MP0001790_abnormal_immune_system1.03140856
94MP0000858_altered_metastatic_potential1.03133949
95MP0002452_abnormal_antigen_presenting1.02963446
96MP0002269_muscular_atrophy1.01972980
97MP0005377_hearing/vestibular/ear_phenot1.01443620
98MP0003878_abnormal_ear_physiology1.01443620
99MP0005266_abnormal_metabolism1.00655706
100MP0004947_skin_inflammation0.99029285
101MP0000749_muscle_degeneration0.97773590
102MP0000716_abnormal_immune_system0.97116390
103MP0000703_abnormal_thymus_morphology0.96491630
104MP0000689_abnormal_spleen_morphology0.96479827
105MP0000759_abnormal_skeletal_muscle0.96021850
106MP0002998_abnormal_bone_remodeling0.95333414
107MP0005666_abnormal_adipose_tissue0.91882308
108MP0002405_respiratory_system_inflammati0.91851878
109MP0009785_altered_susceptibility_to0.91099844
110MP0000678_abnormal_parathyroid_gland0.91051724
111MP0003075_altered_response_to0.90683685
112MP0005369_muscle_phenotype0.90318014
113MP0005397_hematopoietic_system_phenotyp0.89804598
114MP0001545_abnormal_hematopoietic_system0.89804598
115MP0005085_abnormal_gallbladder_physiolo0.86533949
116MP0003252_abnormal_bile_duct0.83612825
117MP0003303_peritoneal_inflammation0.83534598
118MP0002132_abnormal_respiratory_system0.83081693
119MP0000343_altered_response_to0.81345703
120MP0004808_abnormal_hematopoietic_stem0.80871274
121MP0000266_abnormal_heart_morphology0.80478487
122MP0002933_joint_inflammation0.79098736
123MP0001915_intracranial_hemorrhage0.78571475
124MP0005076_abnormal_cell_differentiation0.78448531
125MP0008260_abnormal_autophagy0.78059741
126MP0000733_abnormal_muscle_development0.77835610
127MP0001849_ear_inflammation0.77793759
128MP0000249_abnormal_blood_vessel0.77311507
129MP0000230_abnormal_systemic_arterial0.76929133
130MP0005595_abnormal_vascular_smooth0.76601576
131MP0003656_abnormal_erythrocyte_physiolo0.75889506
132MP0004883_abnormal_blood_vessel0.75695351
133MP0010155_abnormal_intestine_physiology0.75589787
134MP0004085_abnormal_heartbeat0.75031818
135MP0005501_abnormal_skin_physiology0.72390162
136MP0000747_muscle_weakness0.71656955
137MP0005023_abnormal_wound_healing0.71151342
138MP0002128_abnormal_blood_circulation0.70495113
139MP0009115_abnormal_fat_cell0.69749980
140MP0002971_abnormal_brown_adipose0.67928205
141MP0008875_abnormal_xenobiotic_pharmacok0.67627599
142MP0002166_altered_tumor_susceptibility0.67507113
143MP0001533_abnormal_skeleton_physiology0.67247468
144MP0008961_abnormal_basal_metabolism0.67015815
145MP0000609_abnormal_liver_physiology0.66619629
146MP0010329_abnormal_lipoprotein_level0.64519082
147MP0002127_abnormal_cardiovascular_syste0.64364897
148MP0005375_adipose_tissue_phenotype0.63502751
149MP0003137_abnormal_impulse_conducting0.63058303
150MP0002139_abnormal_hepatobiliary_system0.61746432
151MP0001800_abnormal_humoral_immune0.60741311
152MP0008438_abnormal_cutaneous_collagen0.57707168
153MP0008874_decreased_physiological_sensi0.54741098
154MP0005584_abnormal_enzyme/coenzyme_acti0.53991944
155MP0002925_abnormal_cardiovascular_devel0.52300737
156MP0001614_abnormal_blood_vessel0.51788418
157MP0009643_abnormal_urine_homeostasis0.51444743
158MP0001542_abnormal_bone_strength0.51012713

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.30479395
2Petechiae (HP:0000967)6.14672495
3Purpura (HP:0000979)5.49004662
4Increased mean platelet volume (HP:0011877)5.29189827
5Abnormal platelet volume (HP:0011876)5.22341215
6Sudden death (HP:0001699)4.94711346
7Menorrhagia (HP:0000132)4.91101424
8Epistaxis (HP:0000421)4.83343536
9Growth hormone excess (HP:0000845)4.53583717
10Reduced subcutaneous adipose tissue (HP:0003758)4.45486415
11Glucose intolerance (HP:0000833)4.40098094
12Ventricular tachycardia (HP:0004756)4.32957366
13Hypercholesterolemia (HP:0003124)3.99394986
14Lipoatrophy (HP:0100578)3.92245258
15Muscle fiber splitting (HP:0003555)3.82875220
16Impaired platelet aggregation (HP:0003540)3.81724662
17Abnormal platelet function (HP:0011869)3.81724662
18Xerostomia (HP:0000217)3.73086901
19Atrial fibrillation (HP:0005110)3.63819337
20Hyporeflexia of lower limbs (HP:0002600)3.55722886
21Primary atrial arrhythmia (HP:0001692)3.53735113
22Gingival bleeding (HP:0000225)3.52667305
23Spontaneous hematomas (HP:0007420)3.51785874
24Exercise-induced muscle cramps (HP:0003710)3.47240767
25Increased connective tissue (HP:0009025)3.46183972
26Polycythemia (HP:0001901)3.46022727
27Hemorrhage of the eye (HP:0011885)3.38288538
28Orthostatic hypotension (HP:0001278)3.37822259
29Dyschromatopsia (HP:0007641)3.37440174
30Supraventricular arrhythmia (HP:0005115)3.35353596
31Supraventricular tachycardia (HP:0004755)3.34640999
32Exercise-induced myalgia (HP:0003738)3.32855429
33Thin bony cortex (HP:0002753)3.32501009
34Bone cyst (HP:0012062)3.26378303
35Deep venous thrombosis (HP:0002625)3.26275335
36Hypertensive crisis (HP:0100735)3.19369042
37Subaortic stenosis (HP:0001682)3.15545059
38Abnormality of the left ventricular outflow tract (HP:0011103)3.15545059
39Abnormal glucose tolerance (HP:0001952)3.14080164
40Calf muscle hypertrophy (HP:0008981)3.10694376
41Camptodactyly of toe (HP:0001836)3.08474182
42Nonimmune hydrops fetalis (HP:0001790)3.06398536
43Right ventricular cardiomyopathy (HP:0011663)3.05982861
44Mucosal telangiectasiae (HP:0100579)3.01283999
45Atrioventricular block (HP:0001678)2.98278592
46Chondrocalcinosis (HP:0000934)2.93969987
47Bundle branch block (HP:0011710)2.86398279
48Abnormality of the nasal mucosa (HP:0000433)2.81820635
49Cerebral hemorrhage (HP:0001342)2.80614527
50EMG: myopathic abnormalities (HP:0003458)2.79579197
51Difficulty running (HP:0009046)2.79361744
52Mesangial abnormality (HP:0001966)2.78057986
53Large hands (HP:0001176)2.75023573
54Facial diplegia (HP:0001349)2.74855998
55Myoglobinuria (HP:0002913)2.74509885
56Testicular atrophy (HP:0000029)2.74004912
57Abnormality of the calf musculature (HP:0001430)2.69567915
58Ulnar bowing (HP:0003031)2.69523035
59Abnormality of Sharpey fibers (HP:0100685)2.68556779
60Insulin resistance (HP:0000855)2.68278318
61Acanthosis nigricans (HP:0000956)2.67204926
62Muscle hypertrophy of the lower extremities (HP:0008968)2.65575435
63Joint contractures involving the joints of the feet (HP:0100492)2.62893733
64Flexion contracture of toe (HP:0005830)2.62893733
65Difficulty climbing stairs (HP:0003551)2.62079297
66Lymphangioma (HP:0100764)2.61344201
67Dysostosis multiplex (HP:0000943)2.60599738
68Heart block (HP:0012722)2.57827092
69Asymmetric septal hypertrophy (HP:0001670)2.56526309
70Joint hemorrhage (HP:0005261)2.54357933
71Cerebral aneurysm (HP:0004944)2.54112069
72Annular pancreas (HP:0001734)2.53875300
73Dilated cardiomyopathy (HP:0001644)2.50297712
74Abnormality of macrophages (HP:0004311)2.48617168
75Syncope (HP:0001279)2.46545849
76Abnormality of the common coagulation pathway (HP:0010990)2.44904749
77Abnormal atrioventricular conduction (HP:0005150)2.43536167
78Cellulitis (HP:0100658)2.39538765
79Obstructive lung disease (HP:0006536)2.39412529
80Chronic obstructive pulmonary disease (HP:0006510)2.39412529
81Bruising susceptibility (HP:0000978)2.38730242
82Prolonged QT interval (HP:0001657)2.36175107
83Increased variability in muscle fiber diameter (HP:0003557)2.35435043
84Hematochezia (HP:0002573)2.32917386
85Ventricular fibrillation (HP:0001663)2.32772671
86Colitis (HP:0002583)2.28700430
87Acrocyanosis (HP:0001063)2.27585537
88Abnormality of glycolipid metabolism (HP:0010969)2.26406129
89Abnormality of liposaccharide metabolism (HP:0010968)2.26406129
90Abnormality of glycosphingolipid metabolism (HP:0004343)2.26406129
91Hypertriglyceridemia (HP:0002155)2.26131901
92Abnormality of polysaccharide metabolism (HP:0011012)2.24965180
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24965180
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24965180
95Thrombocytosis (HP:0001894)2.23192771
96Myocardial infarction (HP:0001658)2.20958835
97Conjunctival telangiectasia (HP:0000524)2.20875834
98Broad metatarsal (HP:0001783)2.20595501
99Dysmetric saccades (HP:0000641)2.17810031
100Eczematoid dermatitis (HP:0000976)2.16486615
101Gastrointestinal stroma tumor (HP:0100723)2.15982354
102Increased cerebral lipofuscin (HP:0011813)2.15434720
103Ketoacidosis (HP:0001993)2.15249737
104Joint stiffness (HP:0001387)2.14273744
105Distal lower limb amyotrophy (HP:0008944)2.13845961
106Intestinal fistula (HP:0100819)2.12992105
107Centrally nucleated skeletal muscle fibers (HP:0003687)2.11067251
108Ventricular arrhythmia (HP:0004308)2.10890522
109Pulmonary infiltrates (HP:0002113)2.10543942
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.09921909
111Recurrent abscess formation (HP:0002722)2.09151260
112Hepatosplenomegaly (HP:0001433)2.08996063
113Abnormality of skeletal muscle fiber size (HP:0012084)2.08733942
114Myotonia (HP:0002486)2.08551667
115Visceral angiomatosis (HP:0100761)2.07325905
116Hyperthyroidism (HP:0000836)2.06666213
117Urinary glycosaminoglycan excretion (HP:0003541)2.04956713
118Mucopolysacchariduria (HP:0008155)2.04956713
119Palpitations (HP:0001962)2.00177996
120Aneurysm (HP:0002617)2.00125473
121Congestive heart failure (HP:0001635)1.99232490
122Chest pain (HP:0100749)1.97189874
123Abnormality of the intrinsic pathway (HP:0010989)1.95540201
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93828926
125Striae distensae (HP:0001065)1.92949296
126Abnormality of the fingertips (HP:0001211)1.92474987
127Hyperlipoproteinemia (HP:0010980)1.92303825
128Poikilocytosis (HP:0004447)1.92128365
129Abnormality of fatty-acid metabolism (HP:0004359)1.91932657
130Anteriorly placed anus (HP:0001545)1.90434801
131Agammaglobulinemia (HP:0004432)1.89441873
132Ankle contracture (HP:0006466)1.89039310
133Muscle stiffness (HP:0003552)1.88463529
134Gastrointestinal inflammation (HP:0004386)1.88179245
135Verrucae (HP:0200043)1.88142785
136Papilloma (HP:0012740)1.88142785
137Elevated erythrocyte sedimentation rate (HP:0003565)1.87875063
138Capillary hemangiomas (HP:0005306)1.87768676
139Hemangiomatosis (HP:0007461)1.87594658
140Male infertility (HP:0003251)1.86859925
141Hyperpituitarism (HP:0010514)1.86688512
142Abnormality of the hepatic vasculature (HP:0006707)1.86329504
143Clonus (HP:0002169)1.86298958
144Bulbar palsy (HP:0001283)1.85911667
145Myopathic facies (HP:0002058)1.85854712
146Ketosis (HP:0001946)1.85354422
147Fatigue (HP:0012378)1.85345733
148Recurrent bronchitis (HP:0002837)1.83995037
149Squamous cell carcinoma (HP:0002860)1.83558764
150Lymphedema (HP:0001004)1.82870819
151Sudden cardiac death (HP:0001645)1.82729813
152Recurrent bacterial skin infections (HP:0005406)1.82395851
153Prominent supraorbital ridges (HP:0000336)1.81740790
154Rib fusion (HP:0000902)1.81058780
155Limb-girdle muscle atrophy (HP:0003797)1.80776584
156Hypotension (HP:0002615)1.80428166
157Protrusio acetabuli (HP:0003179)1.80376310
158Inflammation of the large intestine (HP:0002037)1.79843781
159Rhabdomyolysis (HP:0003201)1.79223917
160Vaginal fistula (HP:0004320)1.79154556
161Hypoplastic ischia (HP:0003175)1.78871537
162Arterial thrombosis (HP:0004420)1.78390301
163Mitral stenosis (HP:0001718)1.77689730
164Esophageal varix (HP:0002040)1.77432932
165Emphysema (HP:0002097)1.76799360
166Increased serum ferritin (HP:0003281)1.76766181
167Rectal fistula (HP:0100590)1.76555066
168Rectovaginal fistula (HP:0000143)1.76555066
169Abnormality of the costochondral junction (HP:0000919)1.76511488
170Venous insufficiency (HP:0005293)1.76455524
171Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71575390
172Premature graying of hair (HP:0002216)1.71175186
173Ocular albinism (HP:0001107)1.70701526
174Stroke (HP:0001297)1.69755031
175Truncus arteriosus (HP:0001660)1.68922734
176Venous abnormality (HP:0002624)1.68509946
177Easy fatigability (HP:0003388)1.68495795
178Hypoplasia of the iris (HP:0007676)1.66292466
179Thin ribs (HP:0000883)1.65811918
180Abnormality of the heme biosynthetic pathway (HP:0010472)1.65257488
181Paralysis (HP:0003470)1.65066726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.72762505
2TRIB34.13062317
3EPHB13.84450312
4TTN3.50020584
5RIPK43.42073031
6PKN22.91951959
7MAPK152.73434979
8ERN12.64855911
9MAP4K12.63435343
10PRPF4B2.54424747
11BLK2.38748119
12EEF2K2.36476290
13FES2.36271353
14TYK22.32058362
15PTK62.24715375
16MAP3K102.16360261
17FGFR42.14188291
18DMPK2.12981246
19MYLK1.96529040
20KDR1.84509623
21MST41.79068185
22TGFBR21.78951894
23LMTK21.70791601
24TESK21.67578554
25BCKDK1.67508034
26JAK11.62254842
27MAPKAPK31.55435537
28CSF1R1.45597844
29GRK61.39346543
30TGFBR11.36583929
31CDK121.35858302
32NME21.34799463
33IRAK31.34543240
34PTK2B1.32838372
35RIPK11.32221770
36TEC1.30645177
37TAOK21.30427421
38MAP3K111.29621351
39NEK91.28101514
40PIK3CG1.26251277
41SMG11.21694886
42MAP3K61.17558094
43TBK11.17348278
44PRKG21.16202876
45PHKG21.12893185
46PHKG11.12893185
47LRRK21.10551358
48DYRK1B1.07689726
49CSK1.06777372
50FLT31.06572024
51PDK31.02833086
52PDK41.02833086
53MAP3K31.00731634
54MAP3K10.99756550
55STK100.98299538
56PAK40.97436489
57PDGFRA0.96289698
58FGFR30.94756889
59KSR20.91556302
60EPHA30.90788076
61MAP3K70.89944134
62PRKD10.82904407
63DDR20.82231133
64SIK30.81326284
65STK240.80643701
66SIK10.80488531
67BTK0.80275161
68MAP3K130.79853433
69CDK190.78350250
70WNK10.77139243
71JAK20.75807245
72PAK30.74314513
73KIT0.73602796
74LYN0.73021709
75RPS6KA20.72658312
76PRKCH0.72543609
77IKBKB0.72320790
78MAPK70.72129083
79PRKD20.71898793
80MARK20.71286220
81TYRO30.71102072
82MAPK120.70771433
83LCK0.67028513
84ICK0.66273794
85EIF2AK10.65673909
86PAK10.65380440
87NLK0.65354709
88HIPK20.63658856
89MAP2K30.62614653
90MAP2K60.62267801
91IRAK20.61863793
92PIM20.59933758
93MAP3K140.59103910
94WNK40.58775304
95RAF10.58051932
96STK40.57425169
97TLK10.57166364
98ABL10.56183281
99PDK10.55961653
100RPS6KC10.55903435
101RPS6KL10.55903435
102PDGFRB0.55894033
103IKBKE0.55150602
104HCK0.54854136
105CDK60.52851544
106MAP3K80.52735558
107MTOR0.52174531
108CDK40.52069122
109EPHB20.51900181
110STK30.51198503
111ALK0.51020188
112DAPK30.49908208
113ILK0.49666876
114PDPK10.48529533
115RPS6KA60.47512937
116FYN0.47476110
117MAPK40.47277512
118JAK30.47002531
119ZAP700.45461693
120CAMK40.44647643
121SIK20.44631323
122TRPM70.44615267
123TNK20.43643589
124PTK20.43578722
125FER0.43559973
126PDK20.42897864
127ITK0.42674686
128RET0.42661922
129GRK70.42624504
130MARK30.42430032
131SYK0.40161153
132PRKAA10.40059644
133ROCK10.39732527
134MAPK110.39294978
135INSR0.39228778
136ARAF0.39198340
137OBSCN0.38752166
138PRKAA20.37960427
139BMX0.37732226
140ROCK20.37044379
141PAK20.36642343
142SRC0.36173685
143IRAK40.35967499
144PRKD30.35866267
145MATK0.34864428
146CDC42BPA0.33947837

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.62787635
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.97171875
3Fatty acid degradation_Homo sapiens_hsa000712.95018870
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.82095651
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70407517
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.57086866
7Propanoate metabolism_Homo sapiens_hsa006402.50698417
8Viral myocarditis_Homo sapiens_hsa054162.46809664
9Dilated cardiomyopathy_Homo sapiens_hsa054142.28918472
10Other glycan degradation_Homo sapiens_hsa005112.27424813
11Fatty acid metabolism_Homo sapiens_hsa012122.24540183
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07968593
13PPAR signaling pathway_Homo sapiens_hsa033202.01227192
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99365989
15Hematopoietic cell lineage_Homo sapiens_hsa046401.93101023
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90857260
17Focal adhesion_Homo sapiens_hsa045101.86422703
18Sulfur relay system_Homo sapiens_hsa041221.81946688
19B cell receptor signaling pathway_Homo sapiens_hsa046621.79689463
20Arginine biosynthesis_Homo sapiens_hsa002201.77966168
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70561141
22Lysosome_Homo sapiens_hsa041421.58844400
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.53736806
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52278007
25Pancreatic cancer_Homo sapiens_hsa052121.50290864
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44187145
27Tryptophan metabolism_Homo sapiens_hsa003801.40261224
28Nitrogen metabolism_Homo sapiens_hsa009101.39830416
29Carbon metabolism_Homo sapiens_hsa012001.36618337
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35216555
31Insulin resistance_Homo sapiens_hsa049311.34936468
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31655038
33Malaria_Homo sapiens_hsa051441.28178832
34Lysine degradation_Homo sapiens_hsa003101.28177942
35Bladder cancer_Homo sapiens_hsa052191.25360504
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.22920290
37Primary immunodeficiency_Homo sapiens_hsa053401.22528857
38Proteoglycans in cancer_Homo sapiens_hsa052051.22447397
39T cell receptor signaling pathway_Homo sapiens_hsa046601.22074853
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18529709
41Pyruvate metabolism_Homo sapiens_hsa006201.18500842
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18467429
43Adipocytokine signaling pathway_Homo sapiens_hsa049201.18304609
44Fructose and mannose metabolism_Homo sapiens_hsa000511.16722633
45Cardiac muscle contraction_Homo sapiens_hsa042601.16506794
46Butanoate metabolism_Homo sapiens_hsa006501.14428493
47Small cell lung cancer_Homo sapiens_hsa052221.13544121
48Fatty acid elongation_Homo sapiens_hsa000621.12213916
49ECM-receptor interaction_Homo sapiens_hsa045121.10133135
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09092132
51beta-Alanine metabolism_Homo sapiens_hsa004101.08487587
52Complement and coagulation cascades_Homo sapiens_hsa046101.06519666
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05199273
54Osteoclast differentiation_Homo sapiens_hsa043801.05059494
55Tuberculosis_Homo sapiens_hsa051521.04835090
56Toxoplasmosis_Homo sapiens_hsa051451.04594539
57Glycerolipid metabolism_Homo sapiens_hsa005611.04024553
58Notch signaling pathway_Homo sapiens_hsa043301.01243931
59Dorso-ventral axis formation_Homo sapiens_hsa043200.99606677
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97474524
61Inositol phosphate metabolism_Homo sapiens_hsa005620.94774441
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94383064
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93474334
64TNF signaling pathway_Homo sapiens_hsa046680.93367748
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.92680732
66ABC transporters_Homo sapiens_hsa020100.91896518
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90056861
68Platelet activation_Homo sapiens_hsa046110.89724131
69Pentose phosphate pathway_Homo sapiens_hsa000300.88238371
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87706015
71Staphylococcus aureus infection_Homo sapiens_hsa051500.87235645
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87085900
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86686769
74Viral carcinogenesis_Homo sapiens_hsa052030.85158781
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84662322
76Hepatitis B_Homo sapiens_hsa051610.83762694
77Fatty acid biosynthesis_Homo sapiens_hsa000610.82879524
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.77915898
79HIF-1 signaling pathway_Homo sapiens_hsa040660.77717704
80Gap junction_Homo sapiens_hsa045400.77695903
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77478883
82VEGF signaling pathway_Homo sapiens_hsa043700.77259848
83Chronic myeloid leukemia_Homo sapiens_hsa052200.75635803
84Amoebiasis_Homo sapiens_hsa051460.74554265
85Acute myeloid leukemia_Homo sapiens_hsa052210.73862749
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.72457919
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72380204
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70812355
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.70807488
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70300167
91Glucagon signaling pathway_Homo sapiens_hsa049220.69388565
92Insulin signaling pathway_Homo sapiens_hsa049100.69254676
93Apoptosis_Homo sapiens_hsa042100.69199902
94Endometrial cancer_Homo sapiens_hsa052130.68474806
95Biosynthesis of amino acids_Homo sapiens_hsa012300.67924164
96Bile secretion_Homo sapiens_hsa049760.67876010
97mTOR signaling pathway_Homo sapiens_hsa041500.67746470
98Pertussis_Homo sapiens_hsa051330.67149782
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66563930
100AMPK signaling pathway_Homo sapiens_hsa041520.66458510
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66006870
102HTLV-I infection_Homo sapiens_hsa051660.65081604
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.64494496
104Salmonella infection_Homo sapiens_hsa051320.63240601
105GnRH signaling pathway_Homo sapiens_hsa049120.62823490
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62659174
107Renal cell carcinoma_Homo sapiens_hsa052110.62251991
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.61212561
109Rap1 signaling pathway_Homo sapiens_hsa040150.61023167
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60931463
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60018546
112Starch and sucrose metabolism_Homo sapiens_hsa005000.59364612
113Peroxisome_Homo sapiens_hsa041460.57322088
114Sphingolipid metabolism_Homo sapiens_hsa006000.57048773
115Herpes simplex infection_Homo sapiens_hsa051680.55816141
116Prion diseases_Homo sapiens_hsa050200.55622453
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54888634
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54603968
119MAPK signaling pathway_Homo sapiens_hsa040100.54592569
120Adherens junction_Homo sapiens_hsa045200.54055104
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53941135
122Phagosome_Homo sapiens_hsa041450.53866536
123Endocytosis_Homo sapiens_hsa041440.53721713
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52727654
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52410480
126Galactose metabolism_Homo sapiens_hsa000520.52218848
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51468871
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50833650
129Thyroid cancer_Homo sapiens_hsa052160.50141562
130Leishmaniasis_Homo sapiens_hsa051400.48712117
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48001147
132Measles_Homo sapiens_hsa051620.46796676
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46214398
134cAMP signaling pathway_Homo sapiens_hsa040240.44935842
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44285329
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.42980128
137Phenylalanine metabolism_Homo sapiens_hsa003600.41833376
138Non-small cell lung cancer_Homo sapiens_hsa052230.41585679
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39953975
140Pathways in cancer_Homo sapiens_hsa052000.38632343
141Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37987811
142Tight junction_Homo sapiens_hsa045300.37431498
143Hepatitis C_Homo sapiens_hsa051600.37207385
144Choline metabolism in cancer_Homo sapiens_hsa052310.36557613
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35968937
146Shigellosis_Homo sapiens_hsa051310.35326832
147Renin secretion_Homo sapiens_hsa049240.35282378
148Influenza A_Homo sapiens_hsa051640.34896561
149Glioma_Homo sapiens_hsa052140.34072590
150Chemokine signaling pathway_Homo sapiens_hsa040620.32812352
151Type II diabetes mellitus_Homo sapiens_hsa049300.32217320
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.31695415
153Arginine and proline metabolism_Homo sapiens_hsa003300.31409048
154Fat digestion and absorption_Homo sapiens_hsa049750.30415367

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