GIPR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* endocrine pancreas development (GO:0031018)7.00232247
2protein maturation by protein folding (GO:0022417)6.86416042
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.32490956
4peptide hormone processing (GO:0016486)6.31284313
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.23102014
6COPII vesicle coating (GO:0048208)6.16528012
7cilium or flagellum-dependent cell motility (GO:0001539)6.06342661
8glandular epithelial cell differentiation (GO:0002067)5.84684372
9regulation of type B pancreatic cell apoptotic process (GO:2000674)5.83869232
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.79650430
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.72035722
12protein retention in ER lumen (GO:0006621)5.52240053
13axonemal dynein complex assembly (GO:0070286)5.40721585
14axoneme assembly (GO:0035082)5.33666178
15epithelial cilium movement (GO:0003351)5.24567018
16sequestering of metal ion (GO:0051238)5.21833914
17type B pancreatic cell development (GO:0003323)5.19270214
18signal peptide processing (GO:0006465)5.18042398
19insulin secretion (GO:0030073)5.13773905
20cilium movement (GO:0003341)5.11386438
21glandular epithelial cell development (GO:0002068)5.02709295
22exocrine pancreas development (GO:0031017)4.89420743
23vesicle coating (GO:0006901)4.78970841
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.76827281
25* positive regulation of insulin secretion (GO:0032024)4.76131517
26* regulation of insulin secretion (GO:0050796)4.58130570
27positive regulation of nuclease activity (GO:0032075)4.50944548
28detection of calcium ion (GO:0005513)4.49666797
29DNA deamination (GO:0045006)4.38445832
30nitric oxide mediated signal transduction (GO:0007263)4.27056784
31* regulation of peptide hormone secretion (GO:0090276)4.21629940
32epithelial cell fate commitment (GO:0072148)4.18010793
33ER overload response (GO:0006983)4.14401959
34* regulation of peptide secretion (GO:0002791)4.13934475
35regulation of nuclease activity (GO:0032069)4.10980771
36negative regulation of insulin secretion (GO:0046676)4.10583101
37cellular ketone body metabolic process (GO:0046950)4.07402217
38regulation of cilium movement (GO:0003352)3.96872381
39columnar/cuboidal epithelial cell development (GO:0002066)3.91269378
40protein localization to cilium (GO:0061512)3.89881669
41endoplasmic reticulum unfolded protein response (GO:0030968)3.89463604
42* positive regulation of peptide hormone secretion (GO:0090277)3.87686172
43negative regulation of glycoprotein biosynthetic process (GO:0010561)3.85866609
44cellular response to unfolded protein (GO:0034620)3.84999669
45intra-Golgi vesicle-mediated transport (GO:0006891)3.83814884
46peptide hormone secretion (GO:0030072)3.81958261
47ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.80805529
48cellular response to topologically incorrect protein (GO:0035967)3.80399997
49* positive regulation of peptide secretion (GO:0002793)3.75426808
50behavioral response to nicotine (GO:0035095)3.73142187
51peptide secretion (GO:0002790)3.70945898
52ER-nucleus signaling pathway (GO:0006984)3.67841945
53* regulation of hormone secretion (GO:0046883)3.64867642
54astrocyte differentiation (GO:0048708)3.64775706
55ketone body metabolic process (GO:1902224)3.63342578
56toxin metabolic process (GO:0009404)3.57682957
57negative regulation of peptide hormone secretion (GO:0090278)3.57075131
58cellular response to vitamin D (GO:0071305)3.56716080
59protein localization to Golgi apparatus (GO:0034067)3.55965687
60negative regulation of norepinephrine secretion (GO:0010700)3.55748875
61cellular zinc ion homeostasis (GO:0006882)3.53975994
62cytidine deamination (GO:0009972)3.52832345
63cytidine metabolic process (GO:0046087)3.52832345
64cytidine catabolic process (GO:0006216)3.52832345
65regulation of Golgi to plasma membrane protein transport (GO:0042996)3.45850405
66negative regulation of catecholamine secretion (GO:0033604)3.45712647
67negative regulation of protein oligomerization (GO:0032460)3.45004169
68L-alpha-amino acid transmembrane transport (GO:1902475)3.42974121
69negative regulation of peptide secretion (GO:0002792)3.42600290
70respiratory chain complex IV assembly (GO:0008535)3.41842860
71membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.40577888
72regulation of glucocorticoid secretion (GO:2000849)3.37969709
73* regulation of peptide transport (GO:0090087)3.35315711
74ER to Golgi vesicle-mediated transport (GO:0006888)3.34170893
75macroautophagy (GO:0016236)3.28558872
76cilium organization (GO:0044782)3.28353722
77protein polyglutamylation (GO:0018095)3.27451669
78response to hepatocyte growth factor (GO:0035728)3.27424172
79cellular response to hepatocyte growth factor stimulus (GO:0035729)3.27424172
80pyrimidine ribonucleoside catabolic process (GO:0046133)3.26996550
81cellular response to glucagon stimulus (GO:0071377)3.26750539
82fucose catabolic process (GO:0019317)3.24188603
83L-fucose metabolic process (GO:0042354)3.24188603
84L-fucose catabolic process (GO:0042355)3.24188603
85response to endoplasmic reticulum stress (GO:0034976)3.22975902
86positive regulation of glycolytic process (GO:0045821)3.22811774
87negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.20593498
88cilium assembly (GO:0042384)3.19302206
89glycerophospholipid catabolic process (GO:0046475)3.19258870
90protein N-linked glycosylation via asparagine (GO:0018279)3.18891638
91nucleotide transmembrane transport (GO:1901679)3.18713742
92growth hormone secretion (GO:0030252)3.17678925
93peptidyl-asparagine modification (GO:0018196)3.16973169
94platelet dense granule organization (GO:0060155)3.16649263
95motile cilium assembly (GO:0044458)3.11551476
96regulation of energy homeostasis (GO:2000505)3.10841204
97regulation of oxidative phosphorylation (GO:0002082)3.10555469
98response to unfolded protein (GO:0006986)3.09512434
99inositol phosphate catabolic process (GO:0071545)3.09508836
100* positive regulation of hormone secretion (GO:0046887)3.08936615
101regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.07430631
102cerebellar Purkinje cell layer development (GO:0021680)3.05397522
103response to topologically incorrect protein (GO:0035966)3.03730121
104cilium morphogenesis (GO:0060271)3.01504211
105membrane repolarization during action potential (GO:0086011)3.01089810
106response to pheromone (GO:0019236)3.00608475
107regulation of autophagic vacuole assembly (GO:2000785)3.00142367
108regulation of glucokinase activity (GO:0033131)2.99635521
109regulation of hexokinase activity (GO:1903299)2.99635521
110water-soluble vitamin biosynthetic process (GO:0042364)2.99393672
111hormone secretion (GO:0046879)2.98929750
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97719054
113protein N-linked glycosylation (GO:0006487)2.95708410
114* response to hexose (GO:0009746)2.95217603
115negative regulation of bone resorption (GO:0045779)2.93458802
116positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92934899
117glucose homeostasis (GO:0042593)2.91972954
118carbohydrate homeostasis (GO:0033500)2.91972954
119protein import into peroxisome matrix (GO:0016558)2.91164317
120peptide transport (GO:0015833)2.90239224
121induction of positive chemotaxis (GO:0050930)2.90168795
122* response to glucose (GO:0009749)2.89447601
123cytochrome complex assembly (GO:0017004)2.88696184
124positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.87302706
125piRNA metabolic process (GO:0034587)2.85367190
126protein targeting to Golgi (GO:0000042)2.84155329
127negative regulation of telomere maintenance (GO:0032205)2.82980487
128polyol catabolic process (GO:0046174)2.82306622
129intraciliary transport (GO:0042073)2.81715580
130regulation of corticosteroid hormone secretion (GO:2000846)2.81496447
131detection of light stimulus involved in sensory perception (GO:0050962)2.81310479
132detection of light stimulus involved in visual perception (GO:0050908)2.81310479
133microtubule bundle formation (GO:0001578)2.80719742
134Golgi vesicle transport (GO:0048193)2.80501931
135preassembly of GPI anchor in ER membrane (GO:0016254)2.79845331
136negative regulation of glycoprotein metabolic process (GO:1903019)2.79836923
137cornea development in camera-type eye (GO:0061303)2.79758208
138Golgi organization (GO:0007030)2.79713520
139hormone transport (GO:0009914)2.79334721
140* response to monosaccharide (GO:0034284)2.79180678
141regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.78262166
142pharyngeal system development (GO:0060037)2.77957153
143kidney morphogenesis (GO:0060993)2.76942760
144regulation of action potential (GO:0098900)2.73345339
145nephron epithelium morphogenesis (GO:0072088)2.69488205
146nephron tubule morphogenesis (GO:0072078)2.69488205
147nonmotile primary cilium assembly (GO:0035058)2.69301360
148detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68436400
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.66845056
150inositol phosphate dephosphorylation (GO:0046855)2.66845056
151left/right axis specification (GO:0070986)2.66614667
152positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.65697455
153regulation of microtubule-based movement (GO:0060632)2.61888449
154regulation of neurotransmitter uptake (GO:0051580)2.61040184
155cellular component assembly involved in morphogenesis (GO:0010927)2.57313566
156retinal cone cell development (GO:0046549)2.56799119
157rRNA catabolic process (GO:0016075)2.55644526
158regulation of memory T cell differentiation (GO:0043380)2.55453236
159negative regulation of execution phase of apoptosis (GO:1900118)2.55409018
160protein complex biogenesis (GO:0070271)2.55316494
161photoreceptor cell maintenance (GO:0045494)2.54946685
162adult feeding behavior (GO:0008343)2.53590578
163DNA methylation involved in gamete generation (GO:0043046)2.53391046
164reflex (GO:0060004)2.50195161
165protein K11-linked deubiquitination (GO:0035871)2.50077094
166renal tubule morphogenesis (GO:0061333)2.45775731
167regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45478596
168indolalkylamine metabolic process (GO:0006586)2.45348446
169maturation of 5.8S rRNA (GO:0000460)2.44656935
170dendritic spine morphogenesis (GO:0060997)2.43948854
171spinal cord motor neuron differentiation (GO:0021522)2.42200344
172indole-containing compound catabolic process (GO:0042436)2.39587931
173indolalkylamine catabolic process (GO:0046218)2.39587931
174tryptophan catabolic process (GO:0006569)2.39587931
175negative regulation of T cell differentiation in thymus (GO:0033085)2.38265077
176determination of left/right symmetry (GO:0007368)2.38018438
177protein localization to peroxisome (GO:0072662)2.37898458
178protein targeting to peroxisome (GO:0006625)2.37898458
179establishment of protein localization to peroxisome (GO:0072663)2.37898458
180sperm motility (GO:0030317)2.37182864
181somite rostral/caudal axis specification (GO:0032525)2.36028752
182regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.36005440
183regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.36005440
184positive regulation of oligodendrocyte differentiation (GO:0048714)2.35573338
185dopamine transport (GO:0015872)2.34591947
186startle response (GO:0001964)2.32891314
187proline transport (GO:0015824)2.32812443
188dentate gyrus development (GO:0021542)2.31359263
189COPI coating of Golgi vesicle (GO:0048205)10.3241211
190Golgi transport vesicle coating (GO:0048200)10.3241211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.39036754
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.27407694
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.57230074
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54713639
5GATA1_22025678_ChIP-Seq_K562_Human2.48036347
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39900503
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35058595
8REST_21632747_ChIP-Seq_MESCs_Mouse2.13760445
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.03364314
10OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.96605851
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89879943
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86363977
13FUS_26573619_Chip-Seq_HEK293_Human1.86316359
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.84750288
15NR3C1_23031785_ChIP-Seq_PC12_Mouse1.82895941
16ZNF274_21170338_ChIP-Seq_K562_Hela1.82819005
17ER_23166858_ChIP-Seq_MCF-7_Human1.82368196
18CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82284102
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82243705
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79765543
21EWS_26573619_Chip-Seq_HEK293_Human1.78160600
22P300_19829295_ChIP-Seq_ESCs_Human1.74847356
23TAF15_26573619_Chip-Seq_HEK293_Human1.74379026
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.72355457
25BCAT_22108803_ChIP-Seq_LS180_Human1.66840027
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65293434
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64263233
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56772843
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56339725
30REST_19997604_ChIP-ChIP_NEURONS_Mouse1.56241001
31SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.55211942
32IGF1R_20145208_ChIP-Seq_DFB_Human1.52520340
33SMAD4_21799915_ChIP-Seq_A2780_Human1.51555238
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50436031
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50408815
36GBX2_23144817_ChIP-Seq_PC3_Human1.46523194
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.45252147
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45190965
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44443657
40FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44384869
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43965634
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42985842
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.42985842
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42814305
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38252750
46AR_25329375_ChIP-Seq_VCAP_Human1.36893303
47SOX2_19829295_ChIP-Seq_ESCs_Human1.36250451
48NANOG_19829295_ChIP-Seq_ESCs_Human1.36250451
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33960160
50CBP_20019798_ChIP-Seq_JUKART_Human1.32770268
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32770268
52NCOR_22424771_ChIP-Seq_293T_Human1.31153916
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.30524770
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30120152
55GATA1_19941826_ChIP-Seq_K562_Human1.29749987
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29712823
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.28799176
58TCF4_22108803_ChIP-Seq_LS180_Human1.28731739
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28663909
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.27682921
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27664216
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27336029
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.27158572
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.26902834
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26714631
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26654665
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.25784810
68IRF1_19129219_ChIP-ChIP_H3396_Human1.24179382
69DROSHA_22980978_ChIP-Seq_HELA_Human1.23922653
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.23877628
71EZH2_22144423_ChIP-Seq_EOC_Human1.23502198
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23393687
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22915365
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22178513
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.21313464
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21245754
77VDR_22108803_ChIP-Seq_LS180_Human1.20862773
78STAT3_23295773_ChIP-Seq_U87_Human1.20057419
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19583848
80AR_20517297_ChIP-Seq_VCAP_Human1.19176609
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18883397
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17066460
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16490447
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16221126
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15697223
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.14863186
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14069659
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13863649
89FOXA1_25552417_ChIP-Seq_VCAP_Human1.13663962
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13576389
91MYC_19829295_ChIP-Seq_ESCs_Human1.13000387
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12582511
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11059266
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11001776
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.10786089
96GABP_17652178_ChIP-ChIP_JURKAT_Human1.10147140
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09709958
98P53_22387025_ChIP-Seq_ESCs_Mouse1.09656738
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.08899484
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08418883
101TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08303818
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07698495
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.07465394
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.07448805
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07321358
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06345156
107RUNX2_22187159_ChIP-Seq_PCA_Human1.06208764
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05726434
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05726434
110RNF2_27304074_Chip-Seq_NSC_Mouse1.05584321
111PHF8_20622853_ChIP-Seq_HELA_Human1.04799601
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03052081
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02797384
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02306292
115HOXB7_26014856_ChIP-Seq_BT474_Human1.01862887
116ETV1_20927104_ChIP-Seq_GIST48_Human1.01808219
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.01083651
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00847449
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.00559679
120MYC_18940864_ChIP-ChIP_HL60_Human1.00003594
121EP300_21415370_ChIP-Seq_HL-1_Mouse0.99831661
122CDX2_22108803_ChIP-Seq_LS180_Human0.99327923
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98957260
124TFEB_21752829_ChIP-Seq_HELA_Human0.98899886
125NFYB_21822215_ChIP-Seq_K562_Human0.98477014
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98242610
127ERA_21632823_ChIP-Seq_H3396_Human0.98195810
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97403630
129GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97248738
130TAF2_19829295_ChIP-Seq_ESCs_Human0.97188202
131TAL1_26923725_Chip-Seq_HPCs_Mouse0.96784377
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96577311
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.96062857
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95281463
135GF1B_26923725_Chip-Seq_HPCs_Mouse0.94851207
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94216433
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94096594
138CTCF_27219007_Chip-Seq_Bcells_Human0.93612949
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93506952
140SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93114112
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.93110003
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92775792
143TP53_22573176_ChIP-Seq_HFKS_Human0.92448750
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92446725
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.92372170
146SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92009613
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91025759
148RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90708666
149CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90691196
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.89007300
151EZH2_27304074_Chip-Seq_ESCs_Mouse0.88045561
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86852850
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86535168
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86343690
155ERG_20517297_ChIP-Seq_VCAP_Human0.85744270
156TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84679190
157ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84648657
158* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83953928
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83425888
160SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83378997
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82882560
162TCF4_23295773_ChIP-Seq_U87_Human0.82694096
163CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82429647
164TBX20_22080862_ChIP-Seq_HEART_Mouse0.81791610
165TBX20_22328084_ChIP-Seq_HEART_Mouse0.81791610
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81673109
167AR_19668381_ChIP-Seq_PC3_Human0.81252088
168PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77911076
169WT1_19549856_ChIP-ChIP_CCG9911_Human0.77326122
170BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76156333
171ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75841132
172OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75292498
173POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74569163
174ESR1_21235772_ChIP-Seq_MCF-7_Human0.74530991
175JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74514814
176GF1_26923725_Chip-Seq_HPCs_Mouse0.73614192
177FOXH1_21741376_ChIP-Seq_ESCs_Human0.71621119

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.31049535
2MP0003283_abnormal_digestive_organ4.88715093
3MP0004043_abnormal_pH_regulation4.44126807
4MP0009780_abnormal_chondrocyte_physiolo4.32013958
5* MP0002693_abnormal_pancreas_physiology4.04983140
6MP0000013_abnormal_adipose_tissue3.97127019
7MP0002909_abnormal_adrenal_gland3.86293796
8MP0001944_abnormal_pancreas_morphology3.77802862
9MP0003195_calcinosis3.45109512
10MP0000678_abnormal_parathyroid_gland3.26819629
11MP0003183_abnormal_peptide_metabolism3.17795174
12MP0010386_abnormal_urinary_bladder3.17230792
13MP0002837_dystrophic_cardiac_calcinosis3.13981573
14MP0005379_endocrine/exocrine_gland_phen3.13332821
15MP0008877_abnormal_DNA_methylation2.90950710
16MP0005220_abnormal_exocrine_pancreas2.69386511
17MP0006072_abnormal_retinal_apoptosis2.40675347
18MP0003122_maternal_imprinting2.38432805
19MP0001984_abnormal_olfaction2.30900604
20* MP0002078_abnormal_glucose_homeostasis2.27386362
21MP0000003_abnormal_adipose_tissue2.18504664
22MP0005646_abnormal_pituitary_gland2.04352371
23MP0005645_abnormal_hypothalamus_physiol2.00528565
24MP0009046_muscle_twitch1.98167717
25MP0005551_abnormal_eye_electrophysiolog1.98051703
26MP0002638_abnormal_pupillary_reflex1.97872780
27MP0004270_analgesia1.90779638
28MP0002102_abnormal_ear_morphology1.78999583
29MP0002234_abnormal_pharynx_morphology1.76407323
30MP0008875_abnormal_xenobiotic_pharmacok1.76215344
31MP0002928_abnormal_bile_duct1.74665475
32MP0003880_abnormal_central_pattern1.72418416
33MP0000462_abnormal_digestive_system1.66748333
34MP0008872_abnormal_physiological_respon1.65515647
35MP0008961_abnormal_basal_metabolism1.57703874
36MP0009745_abnormal_behavioral_response1.57425194
37MP0000372_irregular_coat_pigmentation1.54871139
38MP0003172_abnormal_lysosome_physiology1.54252892
39MP0001986_abnormal_taste_sensitivity1.53222097
40MP0004264_abnormal_extraembryonic_tissu1.51231075
41MP0000613_abnormal_salivary_gland1.50973180
42MP0004142_abnormal_muscle_tone1.50778039
43MP0008995_early_reproductive_senescence1.47884551
44MP0002896_abnormal_bone_mineralization1.42753805
45MP0002254_reproductive_system_inflammat1.40732081
46MP0005671_abnormal_response_to1.40272996
47MP0004147_increased_porphyrin_level1.37438416
48* MP0003953_abnormal_hormone_level1.37018381
49MP0003119_abnormal_digestive_system1.35265506
50MP0003011_delayed_dark_adaptation1.34335650
51MP0000427_abnormal_hair_cycle1.34094487
52MP0001968_abnormal_touch/_nociception1.31719258
53MP0001765_abnormal_ion_homeostasis1.30918867
54MP0005174_abnormal_tail_pigmentation1.30191871
55MP0002822_catalepsy1.25341288
56MP0002277_abnormal_respiratory_mucosa1.24753756
57MP0002272_abnormal_nervous_system1.23727076
58MP0006276_abnormal_autonomic_nervous1.22584068
59MP0001529_abnormal_vocalization1.22256338
60MP0003787_abnormal_imprinting1.19224188
61MP0001905_abnormal_dopamine_level1.17843567
62MP0000631_abnormal_neuroendocrine_gland1.17276710
63MP0002735_abnormal_chemical_nociception1.15918091
64MP0000569_abnormal_digit_pigmentation1.13390946
65MP0005389_reproductive_system_phenotype1.13032881
66MP0001501_abnormal_sleep_pattern1.11552669
67MP0006082_CNS_inflammation1.11520914
68MP0002163_abnormal_gland_morphology1.11506569
69MP0000516_abnormal_urinary_system1.11498940
70MP0005367_renal/urinary_system_phenotyp1.11498940
71MP0005257_abnormal_intraocular_pressure1.10838696
72MP0004145_abnormal_muscle_electrophysio1.10508655
73MP0003959_abnormal_lean_body1.08916486
74MP0005386_behavior/neurological_phenoty1.08840191
75MP0004924_abnormal_behavior1.08840191
76MP0001502_abnormal_circadian_rhythm1.07169343
77MP0009643_abnormal_urine_homeostasis1.06522667
78MP0003300_gastrointestinal_ulcer1.06376057
79MP0002572_abnormal_emotion/affect_behav1.05559081
80MP0002160_abnormal_reproductive_system1.05092275
81MP0005535_abnormal_body_temperature1.04594079
82MP0000383_abnormal_hair_follicle1.04062583
83MP0003868_abnormal_feces_composition1.04058171
84MP0005332_abnormal_amino_acid1.03461473
85MP0004885_abnormal_endolymph1.01384748
86MP0002064_seizures0.99673248
87MP0009672_abnormal_birth_weight0.98463467
88MP0005375_adipose_tissue_phenotype0.97970951
89MP0001486_abnormal_startle_reflex0.96863619
90MP0002876_abnormal_thyroid_physiology0.96803165
91MP0001756_abnormal_urination0.96519113
92MP0001919_abnormal_reproductive_system0.92441166
93MP0010329_abnormal_lipoprotein_level0.92167630
94MP0005310_abnormal_salivary_gland0.91571359
95MP0002733_abnormal_thermal_nociception0.90929968
96MP0002138_abnormal_hepatobiliary_system0.89883437
97MP0005448_abnormal_energy_balance0.89663819
98MP0003786_premature_aging0.89254305
99MP0001299_abnormal_eye_distance/0.88987615
100MP0003646_muscle_fatigue0.88002893
101MP0000230_abnormal_systemic_arterial0.87223339
102MP0005058_abnormal_lysosome_morphology0.86927751
103MP0004233_abnormal_muscle_weight0.86729879
104MP0001270_distended_abdomen0.86416743
105MP0002067_abnormal_sensory_capabilities0.85341259
106MP0002734_abnormal_mechanical_nocicepti0.84745859
107MP0005253_abnormal_eye_physiology0.84689718
108MP0003879_abnormal_hair_cell0.83793442
109MP0001873_stomach_inflammation0.83729752
110MP0004036_abnormal_muscle_relaxation0.83673970
111MP0005187_abnormal_penis_morphology0.83645122
112MP0003121_genomic_imprinting0.83150720
113MP0006036_abnormal_mitochondrial_physio0.83033368
114MP0004085_abnormal_heartbeat0.82117241
115MP0003045_fibrosis0.81146055
116MP0008789_abnormal_olfactory_epithelium0.80179275
117MP0004019_abnormal_vitamin_homeostasis0.80034416
118MP0003123_paternal_imprinting0.78717244
119MP0000955_abnormal_spinal_cord0.77572674
120MP0004084_abnormal_cardiac_muscle0.76778234
121MP0001764_abnormal_homeostasis0.76492409
122MP0003137_abnormal_impulse_conducting0.76397242
123MP0003890_abnormal_embryonic-extraembry0.76043044
124MP0005423_abnormal_somatic_nervous0.75438560
125MP0002653_abnormal_ependyma_morphology0.75030155
126MP0003252_abnormal_bile_duct0.73250569
127MP0005636_abnormal_mineral_homeostasis0.71474667
128MP0002938_white_spotting0.70253342
129MP0002751_abnormal_autonomic_nervous0.68899946
130MP0000639_abnormal_adrenal_gland0.64476260
131MP0009703_decreased_birth_body0.63798071
132MP0006292_abnormal_olfactory_placode0.61859926
133MP0005452_abnormal_adipose_tissue0.61269265
134MP0000681_abnormal_thyroid_gland0.61001857
135MP0005365_abnormal_bile_salt0.57938962
136MP0005084_abnormal_gallbladder_morpholo0.57620592
137MP0000538_abnormal_urinary_bladder0.57027736
138MP0003634_abnormal_glial_cell0.56951040
139MP0002069_abnormal_eating/drinking_beha0.56906729
140MP0005670_abnormal_white_adipose0.56864831
141MP0001970_abnormal_pain_threshold0.55726239
142MP0006054_spinal_hemorrhage0.55405979
143MP0005334_abnormal_fat_pad0.54551375
144MP0004133_heterotaxia0.53956258
145MP0002177_abnormal_outer_ear0.52552486
146MP0003866_abnormal_defecation0.52049882
147MP0002229_neurodegeneration0.52039996
148MP0002118_abnormal_lipid_homeostasis0.51582807
149MP0005408_hypopigmentation0.51293509
150MP0002557_abnormal_social/conspecific_i0.51277066
151MP0001661_extended_life_span0.51224606
152MP0001348_abnormal_lacrimal_gland0.51200848
153MP0001485_abnormal_pinna_reflex0.47378848
154MP0001731_abnormal_postnatal_growth0.46971332

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.38488638
2Hypoglycemic seizures (HP:0002173)7.86004741
3Symptomatic seizures (HP:0011145)7.12748695
4Hypoglycemic coma (HP:0001325)6.85701287
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.77761075
6Hyperglycemia (HP:0003074)5.17762262
7Insulin-resistant diabetes mellitus (HP:0000831)5.02084074
8Abnormality of the pancreatic islet cells (HP:0006476)4.94280397
9Abnormality of endocrine pancreas physiology (HP:0012093)4.94280397
10Pancreatic islet-cell hyperplasia (HP:0004510)4.87332871
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.78378393
12Absent/shortened dynein arms (HP:0200106)4.78378393
13Abnormal respiratory epithelium morphology (HP:0012253)4.64778760
14Abnormal respiratory motile cilium morphology (HP:0005938)4.64778760
15Ketoacidosis (HP:0001993)4.61921771
16Abnormality of calcium-phosphate metabolism (HP:0100530)4.54905463
17Large for gestational age (HP:0001520)4.39891419
18Late onset (HP:0003584)4.31850830
19Pancreatic cysts (HP:0001737)4.29299695
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.27449883
21Abnormal ciliary motility (HP:0012262)4.24733909
22Abnormal pancreas size (HP:0012094)4.24475847
23Pancreatic fibrosis (HP:0100732)4.21811052
24Abnormal respiratory motile cilium physiology (HP:0012261)4.08509896
25Decreased circulating renin level (HP:0003351)4.00953979
26Abnormality of midbrain morphology (HP:0002418)3.92711807
27Molar tooth sign on MRI (HP:0002419)3.92711807
28True hermaphroditism (HP:0010459)3.83355315
29Nephronophthisis (HP:0000090)3.70237083
30Congenital stationary night blindness (HP:0007642)3.57294349
31Rhinitis (HP:0012384)3.49232759
32Generalized aminoaciduria (HP:0002909)3.48325258
33Osteomalacia (HP:0002749)3.38714617
34Agitation (HP:0000713)3.36281412
35Hypokalemia (HP:0002900)3.33408412
36Medial flaring of the eyebrow (HP:0010747)3.23895486
37Dysostosis multiplex (HP:0000943)3.16161212
38Mucopolysacchariduria (HP:0008155)3.13551474
39Urinary glycosaminoglycan excretion (HP:0003541)3.13551474
40Abnormality of the renal medulla (HP:0100957)3.13359764
41Abnormality of the renal cortex (HP:0011035)3.10890909
42Bronchiectasis (HP:0002110)3.06993473
43Prominent metopic ridge (HP:0005487)3.03800005
44Hyperparathyroidism (HP:0000843)3.03628555
45Insulin resistance (HP:0000855)2.99250368
46Abnormal drinking behavior (HP:0030082)2.94240954
47Polydipsia (HP:0001959)2.94240954
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90703850
49Abnormality of polysaccharide metabolism (HP:0011012)2.90703850
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90703850
51Tubular atrophy (HP:0000092)2.82520550
52Pheochromocytoma (HP:0002666)2.81453937
53Abnormality of renin-angiotensin system (HP:0000847)2.67599497
54Abnormality of potassium homeostasis (HP:0011042)2.65606859
55Visual hallucinations (HP:0002367)2.65059647
56Chronic hepatic failure (HP:0100626)2.63129868
57Abnormality of the metopic suture (HP:0005556)2.57759643
58Unilateral renal agenesis (HP:0000122)2.55006560
59Attenuation of retinal blood vessels (HP:0007843)2.54880246
60Gait imbalance (HP:0002141)2.54009685
61Retinal atrophy (HP:0001105)2.51498691
62Ketosis (HP:0001946)2.49876967
63Congenital primary aphakia (HP:0007707)2.49211974
64EEG with generalized epileptiform discharges (HP:0011198)2.47836989
65Hyperkalemia (HP:0002153)2.47578994
66Hypsarrhythmia (HP:0002521)2.47232079
67Chronic bronchitis (HP:0004469)2.45456466
68Neuroendocrine neoplasm (HP:0100634)2.45188221
69Abnormal rod and cone electroretinograms (HP:0008323)2.44737548
70Dysautonomia (HP:0002459)2.44388420
71Furrowed tongue (HP:0000221)2.43016136
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.40080300
73Hypoplasia of the fovea (HP:0007750)2.40080300
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37092457
75Abolished electroretinogram (ERG) (HP:0000550)2.35831948
76Limb hypertonia (HP:0002509)2.35362286
77Epileptiform EEG discharges (HP:0011182)2.34973239
78Renal cortical cysts (HP:0000803)2.31740400
79Menstrual irregularities (HP:0000858)2.28860112
80Nephrogenic diabetes insipidus (HP:0009806)2.27020565
81Hyperventilation (HP:0002883)2.25403875
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.25305502
83Abnormal albumin level (HP:0012116)2.23967492
84Hypoalbuminemia (HP:0003073)2.23967492
85Cortical visual impairment (HP:0100704)2.23820715
86Congenital hepatic fibrosis (HP:0002612)2.22889743
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18919438
88Conjugated hyperbilirubinemia (HP:0002908)2.18697944
89Methylmalonic acidemia (HP:0002912)2.18516067
90Abnormality of the fovea (HP:0000493)2.17654672
91Congenital glaucoma (HP:0001087)2.16977346
92Polyuria (HP:0000103)2.16145382
93Hyperactive renin-angiotensin system (HP:0000841)2.15330928
94Macroorchidism (HP:0000053)2.14505336
95Male pseudohermaphroditism (HP:0000037)2.14340806
96Occipital encephalocele (HP:0002085)2.13789242
97Hepatoblastoma (HP:0002884)2.13474659
98Hemiparesis (HP:0001269)2.12596550
99Progressive neurologic deterioration (HP:0002344)2.10123782
100Abnormality of the intrinsic pathway (HP:0010989)2.10003569
101Hypomagnesemia (HP:0002917)2.09011687
102Hypercortisolism (HP:0001578)2.08979648
103Thoracolumbar scoliosis (HP:0002944)2.07089509
104Anencephaly (HP:0002323)2.05464213
105Hyperphosphatemia (HP:0002905)2.05434564
106Restlessness (HP:0000711)2.03986026
107Hypothermia (HP:0002045)2.03710274
108Postaxial foot polydactyly (HP:0001830)2.03557376
109Chronic sinusitis (HP:0011109)2.03035741
110Asplenia (HP:0001746)2.02141124
111Abnormality of vitamin B metabolism (HP:0004340)2.01111821
112Gout (HP:0001997)1.99861929
113Abdominal distention (HP:0003270)1.97898563
114Brushfield spots (HP:0001088)1.97009708
115Nasal polyposis (HP:0100582)1.96190059
116Type II lissencephaly (HP:0007260)1.95626424
117Intestinal atresia (HP:0011100)1.95231161
118Sclerocornea (HP:0000647)1.94843798
119Increased circulating renin level (HP:0000848)1.92042688
120Hypotension (HP:0002615)1.91646796
121Myoglobinuria (HP:0002913)1.90839731
122Gaze-evoked nystagmus (HP:0000640)1.90633393
123Bony spicule pigmentary retinopathy (HP:0007737)1.90088655
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.89411499
125Hyperphosphaturia (HP:0003109)1.88958757
126Bifid tongue (HP:0010297)1.88755544
127Exocrine pancreatic insufficiency (HP:0001738)1.88402169
128Pendular nystagmus (HP:0012043)1.88263282
129Stomatitis (HP:0010280)1.87873490
130Mitochondrial inheritance (HP:0001427)1.87637622
131Hypophosphatemia (HP:0002148)1.87631750
132Progressive macrocephaly (HP:0004481)1.86567397
133Disproportionate short-trunk short stature (HP:0003521)1.86086365
134Genital tract atresia (HP:0001827)1.85058793
135Papilledema (HP:0001085)1.83758338
136Thyroiditis (HP:0100646)1.82850395
137Absent speech (HP:0001344)1.81989322
138Cerebellar dysplasia (HP:0007033)1.81935360
139Increased CSF lactate (HP:0002490)1.81797617
140Postaxial hand polydactyly (HP:0001162)1.79920704
141Recurrent sinusitis (HP:0011108)1.78518307
142Papillary thyroid carcinoma (HP:0002895)1.76785842
143Acute necrotizing encephalopathy (HP:0006965)1.76526221
1443-Methylglutaconic aciduria (HP:0003535)1.76488255
145Adrenal overactivity (HP:0002717)1.75585037
146Progressive inability to walk (HP:0002505)1.75526538
147Abnormality of urine glucose concentration (HP:0011016)1.75250754
148Glycosuria (HP:0003076)1.75250754
149Abnormality of macular pigmentation (HP:0008002)1.75133660
150Prolonged QT interval (HP:0001657)1.74913815
151Methylmalonic aciduria (HP:0012120)1.74650561
152Abnormal biliary tract physiology (HP:0012439)1.74297099
153Bile duct proliferation (HP:0001408)1.74297099
154Absent eyebrow (HP:0002223)1.73437318
155Generalized hyperpigmentation (HP:0007440)1.73290212
156Abnormality of chloride homeostasis (HP:0011422)1.71669294
157Cystic liver disease (HP:0006706)1.71611525
158Protuberant abdomen (HP:0001538)1.71323674
159Neoplasm of the adrenal gland (HP:0100631)1.71037890
160Skin nodule (HP:0200036)1.70929424
161Missing ribs (HP:0000921)1.70787276
162Lissencephaly (HP:0001339)1.70154004
163Abnormal urine output (HP:0012590)1.69579335
164Broad-based gait (HP:0002136)1.68860275
165Hypokalemic alkalosis (HP:0001949)1.67416883
166Vaginal atresia (HP:0000148)1.67263903
167Decreased central vision (HP:0007663)1.66513218
168Inability to walk (HP:0002540)1.66258348
169Progressive cerebellar ataxia (HP:0002073)1.66004780
170Hypoplastic labia majora (HP:0000059)1.64613143
171Severe muscular hypotonia (HP:0006829)1.64493808
172Congenital sensorineural hearing impairment (HP:0008527)1.64454670
173Abnormal protein glycosylation (HP:0012346)1.64391939
174Abnormal glycosylation (HP:0012345)1.64391939
175Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64391939
176Abnormal protein N-linked glycosylation (HP:0012347)1.64391939
177Lipid accumulation in hepatocytes (HP:0006561)1.63991097
178Hepatic necrosis (HP:0002605)1.63103479
179Muscular hypotonia of the trunk (HP:0008936)1.62761253
180Villous atrophy (HP:0011473)1.62430490
181Abnormality of small intestinal villus morphology (HP:0011472)1.62430490
182Abnormality of renal excretion (HP:0011036)1.61857670
183Abnormality of glycosphingolipid metabolism (HP:0004343)1.59748382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.76541626
2MAPK155.86767892
3PASK5.62989003
4MAP4K23.28947664
5ADRBK23.00026577
6PRKD32.99303730
7HIPK22.95185521
8WNK42.83213815
9FLT32.80910992
10BMPR1B2.72735719
11MST42.64885695
12MAP3K22.42407390
13TAOK32.37877851
14GRK12.27356807
15NTRK12.19876409
16WNK32.14617797
17TXK2.10277251
18ACVR1B2.10205452
19PINK12.03948586
20FRK1.91676620
21NTRK31.77968833
22UHMK11.73246251
23CASK1.65546837
24CDC42BPA1.58070401
25MAPK131.43777523
26FGFR21.42962960
27TRIB31.42913486
28TRIM281.42138530
29DAPK21.41578211
30PDGFRA1.39494529
31TLK11.39271104
32MAP3K11.38648603
33ERN11.37277749
34SCYL21.36479001
35PTK21.33736818
36MAP3K41.33554400
37NUAK11.31228761
38MET1.28608635
39ZAK1.21243546
40IRAK31.20841271
41PHKG11.20264617
42PHKG21.20264617
43MAP2K61.18098027
44STK38L1.14148257
45DYRK1B1.12131738
46OXSR11.11483783
47CAMKK21.10667042
48PIK3CG1.08525431
49MAPKAPK31.06944777
50PTK61.05468098
51IKBKB1.03956738
52WNK11.03534769
53IRAK11.03275307
54PAK31.02043432
55TESK10.93105567
56PRKCH0.92111540
57PKN20.88965229
58PRKD20.86835598
59MARK10.84789606
60ADRBK10.84379192
61AKT30.83948196
62NLK0.82954662
63BRD40.81876846
64STK30.81423382
65EPHA30.81349841
66PTK2B0.80860347
67BRAF0.76543235
68BRSK20.76203372
69SIK20.74474720
70CSNK1G10.73699294
71STK390.72276238
72PRKCQ0.72208666
73EIF2AK30.71851927
74PRKCI0.69435575
75NME10.67935202
76SIK10.67558813
77CHUK0.66407724
78FGFR30.65470219
79PRKCE0.64695380
80RPS6KA20.63019636
81PRKCZ0.60456298
82PRKAA20.60134950
83PRPF4B0.59850889
84MUSK0.59308633
85MAP3K70.59114741
86CAMK2D0.58821377
87STK110.57422956
88TRPM70.55990986
89BCR0.55985466
90MAP2K20.55879452
91SIK30.55506633
92MARK20.55425437
93TEC0.55045204
94RET0.54257545
95PRKAA10.53131571
96DYRK1A0.51306542
97MAP2K70.50702776
98PNCK0.50193092
99TNK20.49870508
100TGFBR10.49323181
101MKNK20.48023295
102PRKD10.47953794
103IRAK20.47928118
104DYRK30.47083547
105PLK20.46161182
106CAMK2A0.45261373
107LIMK10.45164048
108FER0.44267131
109CDK50.43963064
110RPS6KA50.42544633
111ITK0.42029195
112MAP3K30.41246876
113MTOR0.41015042
114SGK20.40674804
115NEK60.40540054
116CAMKK10.39292803
117BCKDK0.39110263
118MAP3K90.38766116
119KSR20.38733897
120CSNK1A1L0.38469715
121GSK3A0.38228358
122BRSK10.37931907
123PRKACG0.36503642
124SGK2230.36240237
125SGK4940.36240237
126DYRK20.36163175
127TIE10.35536798
128CAMK2B0.35515125
129MAP2K10.34739003
130PRKCA0.34152029
131PKN10.33932565
132MAP4K10.32646947
133ABL10.32431473
134PAK60.32113275
135PRKACA0.31194510
136ARAF0.30910140
137GRK70.30899813
138PRKDC0.30734404
139CSNK1A10.30426062
140ALK0.29750198
141VRK10.29338830
142LYN0.29249333
143JAK20.28238708
144CSNK1G20.27133449
145PRKG10.26426750
146PDGFRB0.25127983
147MAPK140.24834778
148GRK50.24279215
149RPS6KB10.23832511
150IGF1R0.23751905
151STK240.23608248
152MAPK100.23153705
153AKT10.21335408
154BMPR20.20272956
155TNIK0.18495720
156MAPK90.18263944
157RPS6KA30.17947908
158PRKG20.17931572
159PRKCG0.17825407
160ERBB30.17552880
161ILK0.17482665
162CSNK1G30.16979900

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.31011305
2Protein export_Homo sapiens_hsa030605.12975314
3Insulin secretion_Homo sapiens_hsa049113.35639639
4Sulfur metabolism_Homo sapiens_hsa009203.04330039
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.96824213
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62021298
7Type II diabetes mellitus_Homo sapiens_hsa049302.49952880
8Phototransduction_Homo sapiens_hsa047442.35900614
9Vibrio cholerae infection_Homo sapiens_hsa051102.06881250
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02624259
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.00143304
12Type I diabetes mellitus_Homo sapiens_hsa049401.97621362
13Cocaine addiction_Homo sapiens_hsa050301.73432900
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68907948
15Selenocompound metabolism_Homo sapiens_hsa004501.67763424
16Nitrogen metabolism_Homo sapiens_hsa009101.66015245
17N-Glycan biosynthesis_Homo sapiens_hsa005101.55615258
18Peroxisome_Homo sapiens_hsa041461.48897680
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47493965
20Ether lipid metabolism_Homo sapiens_hsa005651.46470075
21Nicotine addiction_Homo sapiens_hsa050331.46105746
22* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45698912
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44323267
24Propanoate metabolism_Homo sapiens_hsa006401.41516688
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35526958
26Lysosome_Homo sapiens_hsa041421.34363200
27Amphetamine addiction_Homo sapiens_hsa050311.29242643
28Caffeine metabolism_Homo sapiens_hsa002321.25774727
29Primary immunodeficiency_Homo sapiens_hsa053401.23411527
30Parkinsons disease_Homo sapiens_hsa050121.22262525
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21175593
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21024679
33Circadian rhythm_Homo sapiens_hsa047101.19352714
34Glucagon signaling pathway_Homo sapiens_hsa049221.18126073
35Graft-versus-host disease_Homo sapiens_hsa053321.17840387
36Chemical carcinogenesis_Homo sapiens_hsa052041.14951363
37Taste transduction_Homo sapiens_hsa047421.14503159
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.13218204
39Fanconi anemia pathway_Homo sapiens_hsa034601.12667005
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.11890287
41Huntingtons disease_Homo sapiens_hsa050161.08671457
42Pancreatic secretion_Homo sapiens_hsa049721.06924115
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05549470
44Other glycan degradation_Homo sapiens_hsa005111.02498074
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02458786
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01943238
47Insulin resistance_Homo sapiens_hsa049311.01062337
48Basal transcription factors_Homo sapiens_hsa030220.99003203
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98067482
50Regulation of autophagy_Homo sapiens_hsa041400.97874267
51Retinol metabolism_Homo sapiens_hsa008300.95932049
52Dopaminergic synapse_Homo sapiens_hsa047280.94401017
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94092570
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93835031
55Circadian entrainment_Homo sapiens_hsa047130.93341207
56Synaptic vesicle cycle_Homo sapiens_hsa047210.91552441
57Rheumatoid arthritis_Homo sapiens_hsa053230.91498985
58Homologous recombination_Homo sapiens_hsa034400.89332669
59Allograft rejection_Homo sapiens_hsa053300.89077557
60Autoimmune thyroid disease_Homo sapiens_hsa053200.88680301
61Butanoate metabolism_Homo sapiens_hsa006500.88270788
62Olfactory transduction_Homo sapiens_hsa047400.87354186
63Prolactin signaling pathway_Homo sapiens_hsa049170.87225410
64Thyroid hormone synthesis_Homo sapiens_hsa049180.85651306
65Long-term potentiation_Homo sapiens_hsa047200.84299130
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82104353
67Cholinergic synapse_Homo sapiens_hsa047250.82056817
68RNA polymerase_Homo sapiens_hsa030200.82053602
69Folate biosynthesis_Homo sapiens_hsa007900.81628731
70Serotonergic synapse_Homo sapiens_hsa047260.80669479
71ABC transporters_Homo sapiens_hsa020100.79612198
72RNA degradation_Homo sapiens_hsa030180.78691825
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78633480
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77903753
75Asthma_Homo sapiens_hsa053100.77497884
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.77493207
77Collecting duct acid secretion_Homo sapiens_hsa049660.76972306
78Estrogen signaling pathway_Homo sapiens_hsa049150.75826496
79GABAergic synapse_Homo sapiens_hsa047270.74880145
80Prion diseases_Homo sapiens_hsa050200.74802045
81Arachidonic acid metabolism_Homo sapiens_hsa005900.73700651
82Galactose metabolism_Homo sapiens_hsa000520.73254118
83beta-Alanine metabolism_Homo sapiens_hsa004100.72328875
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71009342
85Mineral absorption_Homo sapiens_hsa049780.70795222
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68608900
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.65759686
88Insulin signaling pathway_Homo sapiens_hsa049100.65717021
89Tryptophan metabolism_Homo sapiens_hsa003800.65687306
90Glycerolipid metabolism_Homo sapiens_hsa005610.65149049
91Steroid biosynthesis_Homo sapiens_hsa001000.64841948
92Sphingolipid metabolism_Homo sapiens_hsa006000.62095005
93Alcoholism_Homo sapiens_hsa050340.61843506
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60360660
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59925036
96Salivary secretion_Homo sapiens_hsa049700.58383553
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.57899323
98Metabolic pathways_Homo sapiens_hsa011000.56651133
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.56332600
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54277219
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53647730
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53543115
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53367186
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53276667
105Morphine addiction_Homo sapiens_hsa050320.52685811
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52017430
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50800039
108Fatty acid degradation_Homo sapiens_hsa000710.50390272
109Histidine metabolism_Homo sapiens_hsa003400.49970061
110Starch and sucrose metabolism_Homo sapiens_hsa005000.47731858
111Renin secretion_Homo sapiens_hsa049240.46342878
112Fatty acid metabolism_Homo sapiens_hsa012120.45684679
113Linoleic acid metabolism_Homo sapiens_hsa005910.45677240
114Lysine degradation_Homo sapiens_hsa003100.44509303
115AMPK signaling pathway_Homo sapiens_hsa041520.43940231
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41325394
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40090651
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39348919
119Alzheimers disease_Homo sapiens_hsa050100.39051751
120Calcium signaling pathway_Homo sapiens_hsa040200.38854384
121mTOR signaling pathway_Homo sapiens_hsa041500.38683794
122Antigen processing and presentation_Homo sapiens_hsa046120.37284634
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36099423
124Fatty acid elongation_Homo sapiens_hsa000620.34515872
125Phenylalanine metabolism_Homo sapiens_hsa003600.33988584
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33975381
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33779623
128Oxidative phosphorylation_Homo sapiens_hsa001900.33280833
129Glutamatergic synapse_Homo sapiens_hsa047240.31767229
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31617975
131Renal cell carcinoma_Homo sapiens_hsa052110.31334545
132Purine metabolism_Homo sapiens_hsa002300.30699922
133Dorso-ventral axis formation_Homo sapiens_hsa043200.30060929
134* cAMP signaling pathway_Homo sapiens_hsa040240.29962752
135Ovarian steroidogenesis_Homo sapiens_hsa049130.29687683
136Inositol phosphate metabolism_Homo sapiens_hsa005620.29170666
137Dilated cardiomyopathy_Homo sapiens_hsa054140.28012542
138Melanogenesis_Homo sapiens_hsa049160.27704127
139Endometrial cancer_Homo sapiens_hsa052130.27458404
140Cardiac muscle contraction_Homo sapiens_hsa042600.27252010
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26967164
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26509707
143Fat digestion and absorption_Homo sapiens_hsa049750.26128732
144Prostate cancer_Homo sapiens_hsa052150.25473971
145Gap junction_Homo sapiens_hsa045400.24538981
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23663975
147Protein digestion and absorption_Homo sapiens_hsa049740.23177742
148Long-term depression_Homo sapiens_hsa047300.21443157
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20332427
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20137108
151GnRH signaling pathway_Homo sapiens_hsa049120.19258781
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.18627964
153Thyroid cancer_Homo sapiens_hsa052160.18312802
154Adipocytokine signaling pathway_Homo sapiens_hsa049200.17474296

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