GJA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of astrocyte differentiation (GO:0048712)6.44537673
2alanine transport (GO:0032328)6.07944256
3amino acid import (GO:0043090)5.68765227
4regulation of gene silencing by RNA (GO:0060966)5.67534243
5regulation of posttranscriptional gene silencing (GO:0060147)5.67534243
6regulation of gene silencing by miRNA (GO:0060964)5.67534243
7G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.57818705
8desmosome organization (GO:0002934)5.55180298
9paraxial mesoderm development (GO:0048339)5.43804909
10polarized epithelial cell differentiation (GO:0030859)5.38782855
11C4-dicarboxylate transport (GO:0015740)5.31370147
12L-serine transport (GO:0015825)5.20886975
13cellular potassium ion homeostasis (GO:0030007)5.01068807
14regulation of cell fate specification (GO:0042659)4.89525998
15positive regulation of cellular amide metabolic process (GO:0034250)4.83204836
16low-density lipoprotein particle remodeling (GO:0034374)4.77113422
17sodium ion export (GO:0071436)4.75769159
18positive regulation of SMAD protein import into nucleus (GO:0060391)4.58745397
19carnitine metabolic process (GO:0009437)4.49359488
20L-amino acid import (GO:0043092)4.45448727
21serine transport (GO:0032329)4.38998251
22pre-miRNA processing (GO:0031054)4.32449010
23regulation of astrocyte differentiation (GO:0048710)4.28594276
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19373736
25negative regulation of cell fate specification (GO:0009996)4.15500869
26regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.10437106
27negative regulation of smoothened signaling pathway (GO:0045879)4.04985302
28neurotransmitter-gated ion channel clustering (GO:0072578)4.00159489
29cGMP-mediated signaling (GO:0019934)4.00147135
30anterior/posterior axis specification, embryo (GO:0008595)3.97546497
31cellular response to cholesterol (GO:0071397)3.96070176
32dermatan sulfate metabolic process (GO:0030205)3.92257490
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.91785283
34dermatan sulfate biosynthetic process (GO:0030208)3.91155005
35cell surface receptor signaling pathway involved in heart development (GO:0061311)3.90289298
36cellular sodium ion homeostasis (GO:0006883)3.88960900
37negative regulation of sodium ion transport (GO:0010766)3.88773140
38establishment of planar polarity (GO:0001736)3.88226904
39establishment of tissue polarity (GO:0007164)3.88226904
40protein heterotetramerization (GO:0051290)3.86918251
41* cell communication by electrical coupling (GO:0010644)3.86255581
42outer ear morphogenesis (GO:0042473)3.82583382
43establishment of skin barrier (GO:0061436)3.76256560
44negative regulation of glial cell differentiation (GO:0045686)3.75921762
45convergent extension (GO:0060026)3.71394182
46positive regulation of catenin import into nucleus (GO:0035413)3.68727419
47potassium ion import (GO:0010107)3.68674643
48keratinocyte proliferation (GO:0043616)3.68005471
49protein complex localization (GO:0031503)3.62525089
50keratinization (GO:0031424)3.61931971
51negative regulation of catenin import into nucleus (GO:0035414)3.61923481
52glial cell proliferation (GO:0014009)3.54793574
53negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.54125718
54lateral sprouting from an epithelium (GO:0060601)3.50822822
55regulation of water loss via skin (GO:0033561)3.50133706
56regulation of mesoderm development (GO:2000380)3.49587951
57cell migration involved in sprouting angiogenesis (GO:0002042)3.44988061
58chondroitin sulfate catabolic process (GO:0030207)3.44354438
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.44106101
60regulation of cardioblast differentiation (GO:0051890)3.41112950
61heart trabecula morphogenesis (GO:0061384)3.40377044
62negative regulation of cell fate commitment (GO:0010454)3.39127653
63peripheral nervous system axon ensheathment (GO:0032292)3.37585234
64myelination in peripheral nervous system (GO:0022011)3.37585234
65keratinocyte development (GO:0003334)3.37483662
66ovulation cycle (GO:0042698)3.36645096
67cell fate commitment involved in formation of primary germ layer (GO:0060795)3.31282453
68blood vessel maturation (GO:0001955)3.30845804
69regulation of SMAD protein import into nucleus (GO:0060390)3.30411627
70regulation of cell fate commitment (GO:0010453)3.27181418
71cellular response to sterol (GO:0036315)3.26924341
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.26667916
73cellular protein complex localization (GO:0034629)3.25126933
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.25042332
75dorsal/ventral axis specification (GO:0009950)3.23921401
76positive regulation of extracellular matrix organization (GO:1903055)3.22657036
77sphingomyelin metabolic process (GO:0006684)3.20887700
78regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.15971515
79planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15079462
80heterochromatin organization (GO:0070828)3.13917901
81digestive tract morphogenesis (GO:0048546)3.13224397
82hemidesmosome assembly (GO:0031581)3.13094895
83regulation of heat generation (GO:0031650)3.12905098
84regulation of establishment of planar polarity (GO:0090175)3.12744747
85potassium ion homeostasis (GO:0055075)3.12371743
86regulation of hydrogen peroxide-induced cell death (GO:1903205)3.10803326
87establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.10477308
88gamma-aminobutyric acid transport (GO:0015812)3.10425876
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10408130
90regulation of catenin import into nucleus (GO:0035412)3.10058579
91branching involved in salivary gland morphogenesis (GO:0060445)3.09944523
92regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.08899439
93somatic stem cell division (GO:0048103)3.07930100
94non-canonical Wnt signaling pathway (GO:0035567)3.06590649
95negative regulation of response to reactive oxygen species (GO:1901032)3.06215947
96establishment of apical/basal cell polarity (GO:0035089)3.06165886
97apical protein localization (GO:0045176)3.04900706
98vascular smooth muscle contraction (GO:0014829)3.04668968
99one-carbon compound transport (GO:0019755)3.02944158
100glomerular visceral epithelial cell development (GO:0072015)3.01869499
101hippo signaling (GO:0035329)3.01484343
102response to gravity (GO:0009629)3.01456183
103prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.01316306
104lens fiber cell development (GO:0070307)2.99799876
105positive regulation of male gonad development (GO:2000020)2.98572635
106post-anal tail morphogenesis (GO:0036342)2.97839302
107establishment of integrated proviral latency (GO:0075713)2.96882192
108regulation of beta-amyloid formation (GO:1902003)2.95373275
109regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.93731462
110regulation of transforming growth factor beta2 production (GO:0032909)2.92290431
111dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90246917
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90231606
113keratinocyte differentiation (GO:0030216)2.90011817
114renal absorption (GO:0070293)2.89962999
115negative regulation of chondrocyte differentiation (GO:0032331)2.89838715
116neurotransmitter uptake (GO:0001504)2.89086582
117amino-acid betaine metabolic process (GO:0006577)2.86129163
118response to auditory stimulus (GO:0010996)2.86075123
119cell migration involved in gastrulation (GO:0042074)2.84458150
120epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83841341
121cell communication involved in cardiac conduction (GO:0086065)2.83592376
122hyperosmotic salinity response (GO:0042538)2.82550101
123regulation of phospholipid biosynthetic process (GO:0071071)2.82047230
124positive regulation of potassium ion transmembrane transport (GO:1901381)2.81137179
125* regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78917497
126positive regulation of positive chemotaxis (GO:0050927)2.77739440
127negative regulation of keratinocyte proliferation (GO:0010839)2.76919596
128notochord development (GO:0030903)2.75847229
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75767041
130endothelial cell morphogenesis (GO:0001886)2.75241461
131adhesion of symbiont to host cell (GO:0044650)2.72653325
132virion attachment to host cell (GO:0019062)2.72653325
133positive regulation of triglyceride biosynthetic process (GO:0010867)2.71995570
134trabecula morphogenesis (GO:0061383)2.71981214
135regulation of cardiac muscle cell contraction (GO:0086004)2.70975783
136regulation of positive chemotaxis (GO:0050926)2.69350371
137regulation of gene silencing (GO:0060968)2.68672415
138regulation of male gonad development (GO:2000018)2.68651544
139chondrocyte proliferation (GO:0035988)2.68430269
140positive regulation of cardiac muscle cell proliferation (GO:0060045)2.68416026
141tooth mineralization (GO:0034505)2.67634619
142female mating behavior (GO:0060180)2.67290941
143membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64776896
144membrane repolarization (GO:0086009)2.64245974
145aggressive behavior (GO:0002118)2.64069995
146chondroitin sulfate biosynthetic process (GO:0030206)2.63603083
147regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.63075581
148morphogenesis of an epithelial sheet (GO:0002011)2.62224357
149phagocytosis, recognition (GO:0006910)2.61359291
150establishment or maintenance of apical/basal cell polarity (GO:0035088)2.61209723
151establishment or maintenance of bipolar cell polarity (GO:0061245)2.61209723
152intestinal epithelial cell development (GO:0060576)2.60819575
153glomerular epithelial cell development (GO:0072310)2.60416636
154regulation of stem cell maintenance (GO:2000036)2.59642725
155nuclear pore complex assembly (GO:0051292)2.59039971
156endodermal cell differentiation (GO:0035987)2.58663172
157kidney morphogenesis (GO:0060993)2.58087786
158lung-associated mesenchyme development (GO:0060484)2.57895350
159mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57397390
160auditory behavior (GO:0031223)2.57366057
161daunorubicin metabolic process (GO:0044597)2.56122904
162polyketide metabolic process (GO:0030638)2.56122904
163doxorubicin metabolic process (GO:0044598)2.56122904
164bone trabecula formation (GO:0060346)2.55649657
165negative regulation of gliogenesis (GO:0014014)2.55227376
166L-serine metabolic process (GO:0006563)2.55094383
167regulation of actin filament-based movement (GO:1903115)2.54505590
168positive regulation of monocyte chemotaxis (GO:0090026)2.53621369
169mesenchymal to epithelial transition (GO:0060231)2.53084941
170genitalia morphogenesis (GO:0035112)2.52834120
171regulation of integrin-mediated signaling pathway (GO:2001044)2.52749325
172postsynaptic membrane organization (GO:0001941)2.52162331
173endocardial cushion morphogenesis (GO:0003203)2.51300591
174regulation of extracellular matrix organization (GO:1903053)2.49851175
175protein localization to kinetochore (GO:0034501)2.49528319
176estrogen biosynthetic process (GO:0006703)2.49374555
177microglial cell activation (GO:0001774)2.49261056
178regulation of female receptivity (GO:0045924)2.48756295
179chondrocyte development (GO:0002063)2.47277701
180nodal signaling pathway (GO:0038092)2.45763790
181localization within membrane (GO:0051668)2.44935079
182regulation of transforming growth factor beta1 production (GO:0032908)2.44564663
183nuclear pore organization (GO:0006999)2.44383202
184negative regulation of androgen receptor signaling pathway (GO:0060766)2.44185156
185regulation of gastrulation (GO:0010470)2.43821896
186* cell-cell junction assembly (GO:0007043)2.43426820
187regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.42531119
188regulation of keratinocyte proliferation (GO:0010837)2.42404205
189establishment or maintenance of monopolar cell polarity (GO:0061339)2.42168830
190establishment of monopolar cell polarity (GO:0061162)2.42168830
191stem cell division (GO:0017145)2.41095840
192regulation of mesenchymal cell proliferation (GO:0010464)2.40496501
193positive regulation of mesenchymal cell proliferation (GO:0002053)2.39722730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.43366399
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.38973991
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.19387995
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.19387995
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.19387995
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.04661921
7E2F7_22180533_ChIP-Seq_HELA_Human2.85115212
8AR_21572438_ChIP-Seq_LNCaP_Human2.56894323
9* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.51406783
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.50618562
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.48434845
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43818683
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43225633
14* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.42569843
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.41279721
16* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37728158
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37488256
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.29120938
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.26932549
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24353384
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24051178
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23161046
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.20895770
24TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.10315693
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08991388
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08991388
27AR_21909140_ChIP-Seq_LNCAP_Human2.07371562
28CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05623113
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.00633723
30* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97329409
31GBX2_23144817_ChIP-Seq_PC3_Human1.97191408
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91627142
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.90949429
34* NANOG_16153702_ChIP-ChIP_HESCs_Human1.90439125
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88853391
36* RXR_22108803_ChIP-Seq_LS180_Human1.88614535
37CLOCK_20551151_ChIP-Seq_293T_Human1.86857085
38BCAT_22108803_ChIP-Seq_LS180_Human1.85888246
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.82862095
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78996082
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77178073
42TP53_18474530_ChIP-ChIP_U2OS_Human1.76253907
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75458990
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74421814
45TP53_16413492_ChIP-PET_HCT116_Human1.72212111
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.70205684
47* TP53_20018659_ChIP-ChIP_R1E_Mouse1.67997485
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62807244
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62111840
50* SOX2_16153702_ChIP-ChIP_HESCs_Human1.60882032
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.59413207
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59204839
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59071584
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58534382
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57494796
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.56960018
57* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54427210
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50855715
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49796935
60* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48215994
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47726616
62* FUS_26573619_Chip-Seq_HEK293_Human1.46156627
63* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44806891
64* ISL1_27105846_Chip-Seq_CPCs_Mouse1.40487966
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39476603
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38490593
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.37503149
68PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.36708459
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36244968
70* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35941953
71* CJUN_26792858_Chip-Seq_BT549_Human1.35860485
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33872721
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33776810
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.32796717
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32759967
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.31538051
77* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31139414
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30380952
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30063223
80* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29592196
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29022208
82* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28267668
83* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27941022
84AR_25329375_ChIP-Seq_VCAP_Human1.27546885
85* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26472234
86* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25488087
87* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.25153295
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.24732374
89EZH2_22144423_ChIP-Seq_EOC_Human1.23289443
90* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23181479
91* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23181479
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22953106
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.22805223
94* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22652312
95* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20302986
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18300326
97* NANOG_16518401_ChIP-PET_MESCs_Mouse1.17008572
98EWS_26573619_Chip-Seq_HEK293_Human1.16238925
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.15207366
100* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15118565
101* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14912488
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13643700
103* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12707290
104* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12659949
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12230064
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11465818
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.10354021
108* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10293283
109* MYC_18555785_ChIP-Seq_MESCs_Mouse1.09471024
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09462432
111* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09163724
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.08002298
113* P300_19829295_ChIP-Seq_ESCs_Human1.07970263
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06467140
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06342973
116* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05581739
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04113842
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02713724
119TAF15_26573619_Chip-Seq_HEK293_Human1.02261399
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01754317
121BRD4_25478319_ChIP-Seq_HGPS_Human1.00889162
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.99994871
123AHR_22903824_ChIP-Seq_MCF-7_Human0.99692037
124* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99268436
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99199138
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98289095
127* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98256338
128TP63_23658742_ChIP-Seq_EP156T_Human0.98157306
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.97823588
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.97823588
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97588117
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96937739
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96627707
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96005867
135* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95806216
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95750595
137* SOX9_26525672_Chip-Seq_HEART_Mouse0.95342340
138SMAD4_21799915_ChIP-Seq_A2780_Human0.94532095
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93734840
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93660701
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.93609107
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.93344655
143NANOG_21062744_ChIP-ChIP_HESCs_Human0.93321383
144DROSHA_22980978_ChIP-Seq_HELA_Human0.92469189
145* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91866634
146AR_19668381_ChIP-Seq_PC3_Human0.91092934
147KLF5_25053715_ChIP-Seq_YYC3_Human0.90664973
148* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90575131
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90405521
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90280846
151* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89972168
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.89926131
153* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89271406
154* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89254540
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.88643165
156RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88499503
157* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88423669
158* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88358321
159FLI1_27457419_Chip-Seq_LIVER_Mouse0.88348202
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87466502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.66139046
2MP0009780_abnormal_chondrocyte_physiolo4.59796987
3MP0002254_reproductive_system_inflammat3.59201607
4MP0004858_abnormal_nervous_system3.30008939
5MP0005646_abnormal_pituitary_gland3.29143207
6MP0005171_absent_coat_pigmentation3.28352600
7MP0003878_abnormal_ear_physiology3.18776473
8MP0005377_hearing/vestibular/ear_phenot3.18776473
9* MP0002796_impaired_skin_barrier3.06520898
10MP0000566_synostosis3.04987087
11MP0008438_abnormal_cutaneous_collagen2.57925767
12MP0003890_abnormal_embryonic-extraembry2.45769948
13MP0005670_abnormal_white_adipose2.40291639
14MP0010030_abnormal_orbit_morphology2.36724589
15MP0004885_abnormal_endolymph2.22059496
16MP0009379_abnormal_foot_pigmentation2.17055177
17MP0001188_hyperpigmentation2.15544232
18MP0000537_abnormal_urethra_morphology2.08282023
19MP0004957_abnormal_blastocyst_morpholog1.98554954
20* MP0003279_aneurysm1.94299126
21MP0001958_emphysema1.92616924
22MP0005275_abnormal_skin_tensile1.89237385
23MP0002697_abnormal_eye_size1.82277835
24MP0010352_gastrointestinal_tract_polyps1.81894331
25* MP0004215_abnormal_myocardial_fiber1.77609244
26MP0003011_delayed_dark_adaptation1.75582313
27MP0003941_abnormal_skin_development1.75274770
28MP0002233_abnormal_nose_morphology1.74780703
29MP0010234_abnormal_vibrissa_follicle1.72594512
30MP0001293_anophthalmia1.71513507
31MP0004272_abnormal_basement_membrane1.68214452
32MP0002089_abnormal_postnatal_growth/wei1.67663810
33MP0003705_abnormal_hypodermis_morpholog1.66692097
34* MP0003690_abnormal_glial_cell1.66140943
35* MP0009672_abnormal_birth_weight1.64350059
36MP0000462_abnormal_digestive_system1.64093588
37MP0005503_abnormal_tendon_morphology1.62375425
38MP0000751_myopathy1.61599428
39MP0003329_amyloid_beta_deposits1.60612870
40MP0003950_abnormal_plasma_membrane1.58354962
41* MP0005501_abnormal_skin_physiology1.56249271
42MP0004084_abnormal_cardiac_muscle1.55460611
43MP0005257_abnormal_intraocular_pressure1.54757798
44MP0010368_abnormal_lymphatic_system1.49862159
45MP0003119_abnormal_digestive_system1.49611912
46* MP0009384_cardiac_valve_regurgitation1.44544018
47MP0009840_abnormal_foam_cell1.42786231
48MP0003453_abnormal_keratinocyte_physiol1.42783986
49MP0003567_abnormal_fetal_cardiomyocyte1.42232446
50MP0002084_abnormal_developmental_patter1.42073688
51MP0009250_abnormal_appendicular_skeleto1.40556587
52MP0002127_abnormal_cardiovascular_syste1.40514679
53MP0002111_abnormal_tail_morphology1.39761066
54MP0002092_abnormal_eye_morphology1.38636023
55MP0002060_abnormal_skin_morphology1.38468617
56MP0003075_altered_response_to1.36693211
57MP0000579_abnormal_nail_morphology1.34713837
58MP0001485_abnormal_pinna_reflex1.34169249
59MP0001849_ear_inflammation1.33944093
60MP0006054_spinal_hemorrhage1.33522838
61MP0006138_congestive_heart_failure1.32745695
62MP0010678_abnormal_skin_adnexa1.28696411
63MP0002085_abnormal_embryonic_tissue1.27473653
64MP0003385_abnormal_body_wall1.26866695
65MP0001286_abnormal_eye_development1.26735434
66MP0005623_abnormal_meninges_morphology1.26648268
67* MP0002972_abnormal_cardiac_muscle1.24314594
68MP0005647_abnormal_sex_gland1.22513613
69MP0003283_abnormal_digestive_organ1.22020776
70MP0008932_abnormal_embryonic_tissue1.21795698
71MP0009053_abnormal_anal_canal1.21725216
72MP0008057_abnormal_DNA_replication1.21509623
73MP0003646_muscle_fatigue1.19595531
74MP0005595_abnormal_vascular_smooth1.18172772
75MP0000647_abnormal_sebaceous_gland1.17783644
76MP0001984_abnormal_olfaction1.17670223
77* MP0005508_abnormal_skeleton_morphology1.17393935
78* MP0000049_abnormal_middle_ear1.17317572
79MP0001672_abnormal_embryogenesis/_devel1.17191360
80MP0005380_embryogenesis_phenotype1.17191360
81MP0003937_abnormal_limbs/digits/tail_de1.15300375
82MP0000372_irregular_coat_pigmentation1.14816088
83MP0001730_embryonic_growth_arrest1.13615439
84MP0002249_abnormal_larynx_morphology1.13134621
85MP0003984_embryonic_growth_retardation1.11119750
86* MP0000428_abnormal_craniofacial_morphol1.11090680
87MP0005409_darkened_coat_color1.10897750
88MP0003566_abnormal_cell_adhesion1.08073390
89* MP0003137_abnormal_impulse_conducting1.07353977
90MP0002088_abnormal_embryonic_growth/wei1.07097033
91MP0004197_abnormal_fetal_growth/weight/1.02723429
92MP0000762_abnormal_tongue_morphology1.01080230
93MP0001299_abnormal_eye_distance/0.99240817
94MP0004233_abnormal_muscle_weight0.99179038
95MP0003938_abnormal_ear_development0.97761934
96MP0003693_abnormal_embryo_hatching0.97321852
97MP0001502_abnormal_circadian_rhythm0.97028367
98MP0003755_abnormal_palate_morphology0.96673678
99MP0004133_heterotaxia0.96409408
100MP0004130_abnormal_muscle_cell0.95125066
101* MP0010771_integument_phenotype0.95062451
102* MP0009703_decreased_birth_body0.94687790
103* MP0003634_abnormal_glial_cell0.94285741
104MP0004782_abnormal_surfactant_physiolog0.92876992
105* MP0000750_abnormal_muscle_regeneration0.91444504
106MP0000377_abnormal_hair_follicle0.90346078
107MP0002108_abnormal_muscle_morphology0.90182416
108* MP0001216_abnormal_epidermal_layer0.89715638
109MP0002877_abnormal_melanocyte_morpholog0.89211366
110MP0004036_abnormal_muscle_relaxation0.88806615
111MP0000383_abnormal_hair_follicle0.88685547
112MP0001486_abnormal_startle_reflex0.88615778
113* MP0000432_abnormal_head_morphology0.88609066
114MP0002086_abnormal_extraembryonic_tissu0.88504432
115MP0001340_abnormal_eyelid_morphology0.87821429
116MP0001915_intracranial_hemorrhage0.87093612
117* MP0002925_abnormal_cardiovascular_devel0.86972459
118MP0000026_abnormal_inner_ear0.86700133
119* MP0003861_abnormal_nervous_system0.86547979
120MP0003111_abnormal_nucleus_morphology0.86017152
121* MP0005620_abnormal_muscle_contractility0.83523741
122MP0002295_abnormal_pulmonary_circulatio0.83500235
123MP0004883_abnormal_blood_vessel0.83216425
124MP0001697_abnormal_embryo_size0.83052975
125MP0001346_abnormal_lacrimal_gland0.82943157
126MP0003942_abnormal_urinary_system0.82841994
127MP0005165_increased_susceptibility_to0.80488328
128MP0000163_abnormal_cartilage_morphology0.80015027
129* MP0001544_abnormal_cardiovascular_syste0.79141856
130* MP0005385_cardiovascular_system_phenoty0.79141856
131MP0005330_cardiomyopathy0.78664082
132MP0002282_abnormal_trachea_morphology0.78560374
133MP0002090_abnormal_vision0.78365012
134MP0002009_preneoplasia0.78297045
135MP0002653_abnormal_ependyma_morphology0.77227158
136MP0005645_abnormal_hypothalamus_physiol0.77008208
137* MP0005197_abnormal_uvea_morphology0.76825158
138* MP0002116_abnormal_craniofacial_bone0.76276779
139MP0005394_taste/olfaction_phenotype0.75675226
140MP0005499_abnormal_olfactory_system0.75675226
141MP0002896_abnormal_bone_mineralization0.75612363
142MP0005023_abnormal_wound_healing0.75515166
143MP0000467_abnormal_esophagus_morphology0.75300899
144MP0005666_abnormal_adipose_tissue0.75290843
145MP0001661_extended_life_span0.75233935
146MP0002638_abnormal_pupillary_reflex0.75116120
147MP0002876_abnormal_thyroid_physiology0.75104879
148MP0004134_abnormal_chest_morphology0.75082440
149MP0003091_abnormal_cell_migration0.74630405
150MP0003115_abnormal_respiratory_system0.74028089
151MP0000767_abnormal_smooth_muscle0.73172536
152MP0004185_abnormal_adipocyte_glucose0.72165182
153MP0004484_altered_response_of0.71683754
154MP0005187_abnormal_penis_morphology0.71375090
155MP0008789_abnormal_olfactory_epithelium0.70616992
156MP0005388_respiratory_system_phenotype0.70587715
157MP0002133_abnormal_respiratory_system0.70587715
158MP0005253_abnormal_eye_physiology0.69508189
159MP0002098_abnormal_vibrissa_morphology0.69004183
160* MP0002109_abnormal_limb_morphology0.67912871
161MP0002938_white_spotting0.66792129
162MP0001177_atelectasis0.66707508
163MP0001270_distended_abdomen0.66281917
164MP0001879_abnormal_lymphatic_vessel0.65072727
165* MP0003935_abnormal_craniofacial_develop0.64892372
166MP0000749_muscle_degeneration0.64695264

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)4.85910027
2Follicular hyperkeratosis (HP:0007502)4.76317191
3Abnormality of secondary sexual hair (HP:0009888)4.41034559
4Abnormality of the axillary hair (HP:0100134)4.41034559
5* Aplasia involving bones of the extremities (HP:0009825)4.18378456
6* Aplasia involving bones of the upper limbs (HP:0009823)4.18378456
7* Aplasia of the phalanges of the hand (HP:0009802)4.18378456
8Megalencephaly (HP:0001355)4.15636411
9Neonatal short-limb short stature (HP:0008921)3.97334826
10Alopecia of scalp (HP:0002293)3.68411589
11Synostosis involving the elbow (HP:0003938)3.63896234
12Humeroradial synostosis (HP:0003041)3.63896234
13Absent eyelashes (HP:0000561)3.60406205
14Hypoalphalipoproteinemia (HP:0003233)3.40825228
15Hypotrichosis (HP:0001006)3.32587437
16Abnormality of the middle phalanges of the toes (HP:0010183)3.32485727
17Abnormality of nail color (HP:0100643)3.24224852
18Premature rupture of membranes (HP:0001788)3.21184222
19Partial duplication of thumb phalanx (HP:0009944)3.02441566
20Diplopia (HP:0000651)2.93821959
21Abnormality of binocular vision (HP:0011514)2.93821959
22Partial duplication of the phalanx of hand (HP:0009999)2.93265319
23Turricephaly (HP:0000262)2.91984208
24Hemiparesis (HP:0001269)2.91072155
25Choanal stenosis (HP:0000452)2.86551678
26Blepharitis (HP:0000498)2.83444745
27Right ventricular cardiomyopathy (HP:0011663)2.81212513
28Hypoplastic labia majora (HP:0000059)2.75631392
29* Selective tooth agenesis (HP:0001592)2.75568651
30Abnormality of the salivary glands (HP:0010286)2.74221279
31Septo-optic dysplasia (HP:0100842)2.73852990
32Stenosis of the external auditory canal (HP:0000402)2.67647662
33Erythroderma (HP:0001019)2.65668695
34Absent hair (HP:0002298)2.65254364
35Neurofibrillary tangles (HP:0002185)2.63685766
36* Short hallux (HP:0010109)2.62066117
37Broad metatarsal (HP:0001783)2.58344919
38Protrusio acetabuli (HP:0003179)2.57431288
39Back pain (HP:0003418)2.54410631
40Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.53116239
41Hemiplegia (HP:0002301)2.51394467
42Fibular aplasia (HP:0002990)2.50653125
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.49201105
44* Aplasia/Hypoplasia of the hallux (HP:0008362)2.49045806
45* Hypoplastic left heart (HP:0004383)2.47281890
46Abnormality of the labia majora (HP:0012881)2.44460174
47Abnormal sex determination (HP:0012244)2.44101083
48Sex reversal (HP:0012245)2.44101083
49Absent eyebrow (HP:0002223)2.38453157
50Corneal erosion (HP:0200020)2.38011063
51Hyperlipoproteinemia (HP:0010980)2.37953637
52Exercise-induced muscle cramps (HP:0003710)2.36944269
53Natal tooth (HP:0000695)2.36133329
54Bronchomalacia (HP:0002780)2.35824078
55Amelogenesis imperfecta (HP:0000705)2.35159783
56Atrophic scars (HP:0001075)2.32403296
57Hepatoblastoma (HP:0002884)2.31417032
58Myelomeningocele (HP:0002475)2.31155550
59Sensory axonal neuropathy (HP:0003390)2.30493330
60Coronal craniosynostosis (HP:0004440)2.28786144
61Spastic diplegia (HP:0001264)2.28447834
62Vertebral arch anomaly (HP:0008438)2.28100567
63Morphological abnormality of the middle ear (HP:0008609)2.24621250
64Labial hypoplasia (HP:0000066)2.24350906
65Adactyly (HP:0009776)2.23830575
66Palmar hyperkeratosis (HP:0010765)2.23659129
67Symphalangism affecting the phalanges of the hand (HP:0009773)2.23595849
68Microglossia (HP:0000171)2.20888817
69Broad hallux (HP:0010055)2.19956170
70Shallow orbits (HP:0000586)2.19798420
71Broad thumb (HP:0011304)2.19398272
72Arnold-Chiari malformation (HP:0002308)2.18878818
73Abnormality of dentin (HP:0010299)2.17594507
74Hypoplastic scapulae (HP:0000882)2.17578969
75Aplasia/Hypoplasia of the scapulae (HP:0006713)2.17578969
76Hypoplastic female external genitalia (HP:0012815)2.15293302
77Broad toe (HP:0001837)2.14481923
78Abnormality of the nasal septum (HP:0000419)2.11052685
79Palmoplantar hyperkeratosis (HP:0000972)2.10939714
80Esophageal atresia (HP:0002032)2.10821690
81Synostosis of carpal bones (HP:0005048)2.08824416
82Pseudobulbar signs (HP:0002200)2.06766504
83Tarsal synostosis (HP:0008368)2.05619031
84Woolly hair (HP:0002224)2.04991182
85Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03640489
86Hyperglycinuria (HP:0003108)2.03598022
87Split foot (HP:0001839)2.03343910
88Colon cancer (HP:0003003)2.03279064
89Hypoplastic pelvis (HP:0008839)2.02938577
90Abnormality of incisor morphology (HP:0011063)2.01502295
91Overgrowth (HP:0001548)2.01262530
92Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01154266
93* Cutaneous syndactyly (HP:0012725)2.00779443
94Large for gestational age (HP:0001520)2.00522187
95Thick nail (HP:0001805)1.98549743
96Curly hair (HP:0002212)1.96443521
97Plantar hyperkeratosis (HP:0007556)1.95802837
98Atrial fibrillation (HP:0005110)1.94276037
99Soft skin (HP:0000977)1.93716731
100Bilateral microphthalmos (HP:0007633)1.93291035
101Aplasia/Hypoplasia of the clavicles (HP:0006710)1.93254420
102Sparse scalp hair (HP:0002209)1.92911774
103Aplasia/Hypoplasia of the fibula (HP:0006492)1.92622212
104Duplication of thumb phalanx (HP:0009942)1.92309545
105Arterial tortuosity (HP:0005116)1.91910379
106Thickened helices (HP:0000391)1.90630487
107Synostosis involving bones of the lower limbs (HP:0009138)1.89414120
108Synostosis involving bones of the feet (HP:0009140)1.89414120
109Cerebral inclusion bodies (HP:0100314)1.88391566
110Depressed nasal tip (HP:0000437)1.87194924
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.86805507
112Bladder diverticulum (HP:0000015)1.86189184
113Aortic dissection (HP:0002647)1.85968054
1142-3 toe syndactyly (HP:0004691)1.84754356
115Ankle contracture (HP:0006466)1.83496113
116Short nail (HP:0001799)1.82573650
117Biconcave vertebral bodies (HP:0004586)1.82546197
118* Hypoplastic heart (HP:0001961)1.80498931
119Skull defect (HP:0001362)1.79967693
120Sparse eyelashes (HP:0000653)1.79347622
121Omphalocele (HP:0001539)1.78674770
122Abnormality of the labia minora (HP:0012880)1.78651593
123Vascular tortuosity (HP:0004948)1.78621331
124Confusion (HP:0001289)1.77977489
125Aqueductal stenosis (HP:0002410)1.77976351
126Vertebral clefting (HP:0008428)1.77674850
127Preaxial foot polydactyly (HP:0001841)1.76158763
128Broad finger (HP:0001500)1.76079712
129* Absent toe (HP:0010760)1.74796621
130Breast aplasia (HP:0100783)1.73265187
131Stillbirth (HP:0003826)1.73147714
132Brittle hair (HP:0002299)1.72851080
133Deviation of the thumb (HP:0009603)1.72584347
134Abnormal lung lobation (HP:0002101)1.72425184
135Vitreoretinal degeneration (HP:0000655)1.72328114
136Hypoplastic toenails (HP:0001800)1.71984836
137Potter facies (HP:0002009)1.71797091
138Facial shape deformation (HP:0011334)1.71797091
139Gastrointestinal carcinoma (HP:0002672)1.71621368
140Malignant gastrointestinal tract tumors (HP:0006749)1.71621368
141Bifid tongue (HP:0010297)1.71497357
142Primary atrial arrhythmia (HP:0001692)1.71091343
143Adrenal hypoplasia (HP:0000835)1.70965168
144Aplasia/Hypoplasia of the breasts (HP:0010311)1.69582255
145Anophthalmia (HP:0000528)1.69488731
146Abnormality of the septum pellucidum (HP:0007375)1.68439935
147Pterygium (HP:0001059)1.67786508
148Abnormality of the lacrimal duct (HP:0011481)1.67725671
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.66976831
150Broad phalanx (HP:0006009)1.66848298
151Abnormality of the umbilical cord (HP:0010881)1.66690296
152Absent septum pellucidum (HP:0001331)1.66487249
153Mitral valve prolapse (HP:0001634)1.65792816
154* Abnormality of molar (HP:0011077)1.65674072
155* Abnormality of molar morphology (HP:0011070)1.65674072
156Broad phalanges of the hand (HP:0009768)1.65646892
157Bell-shaped thorax (HP:0001591)1.64846264
158Sprengel anomaly (HP:0000912)1.63544121
159Nasolacrimal duct obstruction (HP:0000579)1.63099887
160Short clavicles (HP:0000894)1.62883646
161Cutaneous finger syndactyly (HP:0010554)1.62282863
162* Broad long bones (HP:0005622)1.62226859
163Abnormality of the nasolacrimal system (HP:0000614)1.61495281
164Supernumerary spleens (HP:0009799)1.61015620
165Pulmonary artery stenosis (HP:0004415)1.60152283
166Abnormality of the distal phalanges of the toes (HP:0010182)1.59452821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.51887496
2MUSK4.10200001
3MKNK24.06593623
4TNIK3.99321251
5PHKG13.48511167
6PHKG23.48511167
7NEK63.33169193
8TAF12.79147559
9PRKD32.61160787
10MKNK12.54378685
11EPHA42.53893918
12TRIB32.49554727
13PIK3CA2.30911698
14NTRK22.13093665
15TGFBR12.07709599
16DDR22.01832016
17MAP3K102.01242515
18TTK1.96418474
19BRSK21.93105798
20SIK11.92034385
21PDK21.81242214
22TSSK61.70678114
23SRPK11.67128042
24NTRK11.66904330
25LATS11.62622924
26IRAK31.53809276
27EEF2K1.51943350
28LATS21.48239044
29FGFR21.47498922
30TTN1.45084505
31STK241.44244300
32MAP3K91.39795143
33PLK31.37956961
34STK38L1.36037616
35EPHA21.33586145
36FGFR11.32200860
37CDC71.31904609
38PDGFRA1.31357883
39NLK1.30380720
40SGK21.22831828
41PAK31.21814320
42BRD41.21788070
43MAPK131.18854158
44PAK41.14689919
45DYRK31.11932233
46ERBB31.11795595
47PDK41.11161470
48PDK31.11161470
49BUB11.11157435
50PINK11.10472386
51ROCK11.06281009
52CDK61.06011713
53FER1.05568129
54PNCK1.02221127
55PLK40.98968540
56WEE10.98200700
57PTK20.95254092
58SGK30.95058796
59CAMK1G0.93236553
60TYRO30.90530589
61CDK80.86636275
62AKT30.86608830
63DYRK1A0.81617354
64CASK0.80733475
65KDR0.79667723
66PLK20.78903047
67EPHB20.74135928
68RIPK10.73290093
69CDK190.72740125
70CDK120.72214498
71SGK2230.70819521
72SGK4940.70819521
73MAP2K70.69326929
74BMX0.68937505
75FGFR30.68491733
76SMG10.68318939
77PAK20.67515053
78VRK20.67354939
79DYRK20.66151750
80TIE10.64469324
81ADRBK10.63290732
82CSNK1G10.63233076
83CAMK1D0.62947571
84DMPK0.61682451
85BCR0.61031969
86NEK10.60863512
87CDC42BPA0.59466300
88PLK10.56747297
89EIF2AK20.55789153
90* PRKCG0.55052190
91ROCK20.53628457
92ILK0.53627896
93* PRKCE0.53458551
94BRSK10.52856763
95NUAK10.52275279
96SGK10.51616734
97ZAK0.51585130
98MYLK0.51127535
99PRKAA20.50459667
100CDK30.50415100
101TGFBR20.50027566
102PRKACB0.49491675
103TRPM70.48679676
104FGR0.48504934
105MTOR0.48503416
106PRKCH0.48488044
107AKT20.48097387
108MOS0.47755140
109CAMK2A0.47653706
110PRKD10.47443910
111MST40.46121383
112STK380.46035460
113CDK40.45710384
114CSNK1A10.43824816
115ATM0.42796423
116PDGFRB0.42262364
117TAOK20.41540645
118CSNK1E0.40964300
119FGFR40.39875752
120STK30.39678705
121MET0.39465100
122CHEK20.38439525
123PBK0.37935911
124STK100.37343117
125FLT30.36868197
126CAMK2G0.36297319
127* PRKCA0.36116177
128OBSCN0.35586472
129* IGF1R0.35488772
130CDK70.34856778
131CAMK2D0.34681778
132NEK90.34605002
133ERBB40.34539908
134PRKG20.34413187
135EGFR0.34136994
136GRK10.33235982
137PRKACA0.32926934
138CHEK10.31319288
139PRKAA10.30231138
140LIMK10.30221692
141CSNK1G20.29854984
142RPS6KB10.29295493
143* GSK3B0.28915145
144MINK10.28839342
145MAPK100.28532121
146PTK60.28523895
147PRKACG0.28416383
148PRKDC0.28395861
149STK40.28249562
150CDK20.27161668
151ALK0.27152235
152MELK0.27092349
153PRKD20.27021534
154RPS6KA40.27016389
155MAPK40.25153155
156CDK150.24034830
157RPS6KA30.23988686
158MAP3K30.23690701

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.99542893
2Nitrogen metabolism_Homo sapiens_hsa009103.54677646
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.46653586
4Fatty acid metabolism_Homo sapiens_hsa012122.99083182
5Fatty acid degradation_Homo sapiens_hsa000712.74864867
6Basal cell carcinoma_Homo sapiens_hsa052172.21536985
7ECM-receptor interaction_Homo sapiens_hsa045122.19746449
8Steroid biosynthesis_Homo sapiens_hsa001002.16663029
9Circadian rhythm_Homo sapiens_hsa047102.00225915
10* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90325486
11Thyroid cancer_Homo sapiens_hsa052161.87419984
12Sphingolipid metabolism_Homo sapiens_hsa006001.82647754
13Dilated cardiomyopathy_Homo sapiens_hsa054141.82309540
14Propanoate metabolism_Homo sapiens_hsa006401.74894335
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73190219
16Mineral absorption_Homo sapiens_hsa049781.72883778
17Histidine metabolism_Homo sapiens_hsa003401.63619875
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61077099
19Vitamin digestion and absorption_Homo sapiens_hsa049771.60621245
20PPAR signaling pathway_Homo sapiens_hsa033201.56003219
21Cell cycle_Homo sapiens_hsa041101.49923516
22mRNA surveillance pathway_Homo sapiens_hsa030151.43504466
23Amoebiasis_Homo sapiens_hsa051461.38117724
24Arginine and proline metabolism_Homo sapiens_hsa003301.37851971
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36785100
26p53 signaling pathway_Homo sapiens_hsa041151.36382874
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34504382
28Spliceosome_Homo sapiens_hsa030401.30446625
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29544659
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28822666
31Hedgehog signaling pathway_Homo sapiens_hsa043401.28070271
32Gastric acid secretion_Homo sapiens_hsa049711.24899221
33Melanogenesis_Homo sapiens_hsa049161.22989055
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22493504
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21738961
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21125468
37Bile secretion_Homo sapiens_hsa049761.18759859
38Hippo signaling pathway_Homo sapiens_hsa043901.17329742
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17317732
40TGF-beta signaling pathway_Homo sapiens_hsa043501.16650449
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16469080
42RNA transport_Homo sapiens_hsa030131.15268988
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12996974
44Proteoglycans in cancer_Homo sapiens_hsa052051.11934491
45Salivary secretion_Homo sapiens_hsa049701.11470375
46Protein digestion and absorption_Homo sapiens_hsa049741.11091485
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09371376
48Malaria_Homo sapiens_hsa051441.09297628
49Cardiac muscle contraction_Homo sapiens_hsa042601.06792380
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06183767
51Focal adhesion_Homo sapiens_hsa045101.06180109
52Mismatch repair_Homo sapiens_hsa034301.05290502
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.04507263
54Lysine degradation_Homo sapiens_hsa003101.00483743
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99425543
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99191367
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99091733
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98998576
59Fructose and mannose metabolism_Homo sapiens_hsa000510.97997194
60DNA replication_Homo sapiens_hsa030300.97671607
61Selenocompound metabolism_Homo sapiens_hsa004500.97219665
62Oocyte meiosis_Homo sapiens_hsa041140.95152975
63Colorectal cancer_Homo sapiens_hsa052100.94948298
64Prostate cancer_Homo sapiens_hsa052150.94799302
65Calcium signaling pathway_Homo sapiens_hsa040200.94118852
66Carbon metabolism_Homo sapiens_hsa012000.93743067
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92219427
68Dorso-ventral axis formation_Homo sapiens_hsa043200.91603666
69Wnt signaling pathway_Homo sapiens_hsa043100.89923656
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.88930026
71Small cell lung cancer_Homo sapiens_hsa052220.88658762
72Fatty acid elongation_Homo sapiens_hsa000620.88232237
73Adherens junction_Homo sapiens_hsa045200.88139542
74Basal transcription factors_Homo sapiens_hsa030220.87068986
75Nicotine addiction_Homo sapiens_hsa050330.85818817
76Ras signaling pathway_Homo sapiens_hsa040140.84807559
77Non-homologous end-joining_Homo sapiens_hsa034500.83872425
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83458444
79Ovarian steroidogenesis_Homo sapiens_hsa049130.83301731
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.83078982
81Biosynthesis of amino acids_Homo sapiens_hsa012300.80487164
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80069304
83Insulin secretion_Homo sapiens_hsa049110.79196332
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78140061
85GABAergic synapse_Homo sapiens_hsa047270.77701222
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76468001
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76019481
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75769655
89Endometrial cancer_Homo sapiens_hsa052130.75443852
90Long-term depression_Homo sapiens_hsa047300.75112722
91Glutamatergic synapse_Homo sapiens_hsa047240.74129348
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71634977
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.67646922
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67376624
95Protein export_Homo sapiens_hsa030600.67372284
96Bladder cancer_Homo sapiens_hsa052190.67219214
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66476192
98African trypanosomiasis_Homo sapiens_hsa051430.62601249
99cAMP signaling pathway_Homo sapiens_hsa040240.62079279
100Notch signaling pathway_Homo sapiens_hsa043300.61581098
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60328915
102Choline metabolism in cancer_Homo sapiens_hsa052310.60288763
103Thyroid hormone synthesis_Homo sapiens_hsa049180.58655360
104Peroxisome_Homo sapiens_hsa041460.57424176
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56601208
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56570664
107Tight junction_Homo sapiens_hsa045300.55309343
108Glucagon signaling pathway_Homo sapiens_hsa049220.54746162
109* Gap junction_Homo sapiens_hsa045400.53785457
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.53488870
111Ether lipid metabolism_Homo sapiens_hsa005650.52424083
112RNA degradation_Homo sapiens_hsa030180.52068801
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51933733
114Pathways in cancer_Homo sapiens_hsa052000.51581919
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51496817
116Long-term potentiation_Homo sapiens_hsa047200.50554961
117Serotonergic synapse_Homo sapiens_hsa047260.50469199
118Melanoma_Homo sapiens_hsa052180.50237279
119Circadian entrainment_Homo sapiens_hsa047130.50195429
120Pyruvate metabolism_Homo sapiens_hsa006200.49692489
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.49634720
122Nucleotide excision repair_Homo sapiens_hsa034200.49596284
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48601505
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47738346
125Rap1 signaling pathway_Homo sapiens_hsa040150.47540495
126Glycerolipid metabolism_Homo sapiens_hsa005610.47109462
127Pancreatic secretion_Homo sapiens_hsa049720.45321879
128Sulfur metabolism_Homo sapiens_hsa009200.41313719
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41075383
130Inositol phosphate metabolism_Homo sapiens_hsa005620.40455977
131Pentose phosphate pathway_Homo sapiens_hsa000300.40348592
132One carbon pool by folate_Homo sapiens_hsa006700.39375046
133ErbB signaling pathway_Homo sapiens_hsa040120.38762016
134Glioma_Homo sapiens_hsa052140.38621701
135Insulin resistance_Homo sapiens_hsa049310.38164487
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.35969945
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.35272326
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30770638
139Renin secretion_Homo sapiens_hsa049240.30435438
140Axon guidance_Homo sapiens_hsa043600.30080905
141Cocaine addiction_Homo sapiens_hsa050300.29131726
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29119845
143MicroRNAs in cancer_Homo sapiens_hsa052060.28985699
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28951947
145Sulfur relay system_Homo sapiens_hsa041220.27890807
146Vitamin B6 metabolism_Homo sapiens_hsa007500.27642733

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