GJA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of autophagic vacuole assembly (GO:2000785)8.46202356
2regulation of vacuole organization (GO:0044088)6.60982045
3regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.60873835
4gamma-aminobutyric acid transport (GO:0015812)6.50121641
5substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.11427949
6substrate-independent telencephalic tangential migration (GO:0021826)6.11427949
7neuron cell-cell adhesion (GO:0007158)5.90909198
8lipoprotein transport (GO:0042953)4.93787436
9regulation of relaxation of muscle (GO:1901077)4.86832947
10necroptotic process (GO:0070266)4.54621926
11sarcoplasmic reticulum calcium ion transport (GO:0070296)4.36958182
12response to pheromone (GO:0019236)4.27269639
13DNA damage response, detection of DNA damage (GO:0042769)4.12952574
14negative regulation of stem cell proliferation (GO:2000647)4.10807824
15acylglycerol homeostasis (GO:0055090)3.72713817
16triglyceride homeostasis (GO:0070328)3.72713817
17central nervous system projection neuron axonogenesis (GO:0021952)3.72450716
18axonal fasciculation (GO:0007413)3.67596952
19response to hydroperoxide (GO:0033194)3.67216505
20cerebral cortex radially oriented cell migration (GO:0021799)3.66778839
21hindbrain development (GO:0030902)3.63678951
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.59508476
23L-phenylalanine catabolic process (GO:0006559)3.59508476
24positive regulation of protein depolymerization (GO:1901881)3.55937001
25oocyte maturation (GO:0001556)3.54302253
26tyrosine phosphorylation of STAT protein (GO:0007260)3.54301580
27mRNA polyadenylation (GO:0006378)3.52374137
28mitotic cell cycle arrest (GO:0071850)3.46501618
29protein K11-linked ubiquitination (GO:0070979)3.42807761
30regulation of RIG-I signaling pathway (GO:0039535)3.42731876
31multicellular organism reproduction (GO:0032504)3.39634774
32pyridine nucleotide biosynthetic process (GO:0019363)3.38948440
33nicotinamide nucleotide biosynthetic process (GO:0019359)3.38948440
34glycerophospholipid catabolic process (GO:0046475)3.36543960
35tachykinin receptor signaling pathway (GO:0007217)3.35340850
36response to ischemia (GO:0002931)3.34417086
37negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.32645443
38synaptic transmission, glutamatergic (GO:0035249)3.27984651
39S-adenosylmethionine metabolic process (GO:0046500)3.26330544
40kynurenine metabolic process (GO:0070189)3.25280835
41regulation of cholesterol homeostasis (GO:2000188)3.22946944
42positive regulation of triglyceride lipase activity (GO:0061365)3.22875081
43positive regulation of lipoprotein lipase activity (GO:0051006)3.22875081
44aromatic amino acid family catabolic process (GO:0009074)3.20124307
45cellular response to arsenic-containing substance (GO:0071243)3.19063308
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.18896671
47L-phenylalanine metabolic process (GO:0006558)3.18896671
48lung secretory cell differentiation (GO:0061140)3.17730137
49mitotic sister chromatid cohesion (GO:0007064)3.13816352
50positive regulation of uterine smooth muscle contraction (GO:0070474)3.09817648
51monoubiquitinated protein deubiquitination (GO:0035520)3.07798860
52glycosphingolipid biosynthetic process (GO:0006688)3.07470681
53phospholipid translocation (GO:0045332)3.06053126
54lipid translocation (GO:0034204)3.06053126
55positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.05894897
56RNA polyadenylation (GO:0043631)3.05312855
57urea metabolic process (GO:0019627)3.04346991
58urea cycle (GO:0000050)3.04346991
59regulation of female gonad development (GO:2000194)3.04339721
60righting reflex (GO:0060013)3.04028748
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.03219959
62axon extension involved in axon guidance (GO:0048846)3.03219959
63indole-containing compound catabolic process (GO:0042436)3.01074257
64indolalkylamine catabolic process (GO:0046218)3.01074257
65tryptophan catabolic process (GO:0006569)3.01074257
66cellular anion homeostasis (GO:0030002)3.00768265
67negative regulation of autophagy (GO:0010507)2.98040532
68negative regulation of fibrinolysis (GO:0051918)2.97438280
69morphogenesis of embryonic epithelium (GO:0016331)2.94982182
70magnesium ion transport (GO:0015693)2.91984008
71regulation of synaptic vesicle exocytosis (GO:2000300)2.91899533
72positive regulation of synapse maturation (GO:0090129)2.91585991
73regulation of fibrinolysis (GO:0051917)2.91131959
74establishment of mitochondrion localization (GO:0051654)2.90115646
75behavioral response to nicotine (GO:0035095)2.89505333
76programmed necrotic cell death (GO:0097300)2.89195177
77piRNA metabolic process (GO:0034587)2.87283271
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86021719
79mitochondrion transport along microtubule (GO:0047497)2.86021719
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85191253
81acetyl-CoA metabolic process (GO:0006084)2.84879217
82telencephalon cell migration (GO:0022029)2.81436927
83growth hormone receptor signaling pathway (GO:0060396)2.81192487
84regulation of protein activation cascade (GO:2000257)2.80674627
85inactivation of MAPK activity (GO:0000188)2.77766145
86regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.77535654
87peptidyl-tyrosine autophosphorylation (GO:0038083)2.77305101
88central nervous system neuron axonogenesis (GO:0021955)2.77287805
89necrotic cell death (GO:0070265)2.77220272
90negative regulation of chondrocyte differentiation (GO:0032331)2.73880774
91branch elongation of an epithelium (GO:0060602)2.73745949
92nonmotile primary cilium assembly (GO:0035058)2.73507570
93regulation of triglyceride catabolic process (GO:0010896)2.72363461
94regulation of mononuclear cell migration (GO:0071675)2.72135214
95positive regulation of triglyceride biosynthetic process (GO:0010867)2.70658933
96negative regulation of lipase activity (GO:0060192)2.69613387
97negative regulation of membrane potential (GO:0045837)2.69525443
98negative regulation of telomerase activity (GO:0051974)2.68573803
99pyridine-containing compound biosynthetic process (GO:0072525)2.67499815
100DNA damage induced protein phosphorylation (GO:0006975)11.6270815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.87973546
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.52382319
3EZH2_22144423_ChIP-Seq_EOC_Human2.92483491
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.74161897
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35568013
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19955663
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19331461
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.16319619
9GBX2_23144817_ChIP-Seq_PC3_Human2.11252136
10RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.09665064
11SMAD3_21741376_ChIP-Seq_HESCs_Human2.04105028
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.02491838
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00152766
14TP63_19390658_ChIP-ChIP_HaCaT_Human1.94940809
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89520462
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88805581
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85180027
18LXR_22158963_ChIP-Seq_LIVER_Mouse1.84869219
19TP53_16413492_ChIP-PET_HCT116_Human1.81395552
20ISL1_27105846_Chip-Seq_CPCs_Mouse1.80436608
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78626614
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78626614
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77323151
24SMAD4_21741376_ChIP-Seq_HESCs_Human1.64713827
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64222725
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.61407023
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.59631273
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59057986
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55991609
30AR_21572438_ChIP-Seq_LNCaP_Human1.53315996
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51908844
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51392952
33TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.50555297
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49049862
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42328302
36AHR_22903824_ChIP-Seq_MCF-7_Human1.39251975
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38067243
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37826653
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37186229
40SOX2_21211035_ChIP-Seq_LN229_Gbm1.37030522
41CLOCK_20551151_ChIP-Seq_293T_Human1.36874561
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36861270
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36761003
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35868085
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34306169
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34168280
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.33996478
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32252235
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30730775
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30347122
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30068247
52SMAD4_21799915_ChIP-Seq_A2780_Human1.25168731
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24120350
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23854540
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23439584
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.23138659
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22226945
58* P300_19829295_ChIP-Seq_ESCs_Human1.19842045
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19300811
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18598536
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.18385062
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18218242
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17877384
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16350569
65VDR_24787735_ChIP-Seq_THP-1_Human1.14225566
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.14216322
67* AR_25329375_ChIP-Seq_VCAP_Human1.13236403
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.12250997
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11020652
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10052083
71NANOG_19829295_ChIP-Seq_ESCs_Human1.09701028
72SOX2_19829295_ChIP-Seq_ESCs_Human1.09701028
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07738977
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.06386706
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.05411654
76TCF4_23295773_ChIP-Seq_U87_Human1.02470515
77KDM2B_26808549_Chip-Seq_REH_Human1.02403634
78RNF2_27304074_Chip-Seq_NSC_Mouse1.01281041
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99481632
80WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98574524
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.98426839
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97918423
83FUS_26573619_Chip-Seq_HEK293_Human0.97484595
84AR_19668381_ChIP-Seq_PC3_Human0.97144617
85ARNT_22903824_ChIP-Seq_MCF-7_Human0.97061368
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96528284
87TBL1_22424771_ChIP-Seq_293T_Human0.96152876
88CJUN_26792858_Chip-Seq_BT549_Human0.95891585
89* STAT3_23295773_ChIP-Seq_U87_Human0.95766929
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95615262
91POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94728510
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93116926
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92502213
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92004638
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.90917413
96* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89296270
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88789091
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88462961
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87641994
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86525495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.29847902
2MP0005085_abnormal_gallbladder_physiolo4.23363440
3MP0002735_abnormal_chemical_nociception4.19047492
4MP0002736_abnormal_nociception_after3.81821640
5MP0005365_abnormal_bile_salt3.60823271
6MP0003123_paternal_imprinting3.58786027
7MP0005360_urolithiasis3.55591896
8MP0004859_abnormal_synaptic_plasticity3.41919603
9MP0002653_abnormal_ependyma_morphology3.18138922
10MP0009840_abnormal_foam_cell3.03369901
11MP0003121_genomic_imprinting2.86207862
12MP0003656_abnormal_erythrocyte_physiolo2.76431357
13MP0001968_abnormal_touch/_nociception2.74188723
14MP0005670_abnormal_white_adipose2.60986983
15MP0004885_abnormal_endolymph2.28484002
16MP0000778_abnormal_nervous_system2.13773504
17MP0001177_atelectasis2.12823501
18MP0003191_abnormal_cellular_cholesterol2.09179134
19MP0002163_abnormal_gland_morphology1.89453674
20* MP0005551_abnormal_eye_electrophysiolog1.81925999
21MP0006292_abnormal_olfactory_placode1.81119711
22MP0003252_abnormal_bile_duct1.80361529
23MP0005379_endocrine/exocrine_gland_phen1.76857732
24MP0004019_abnormal_vitamin_homeostasis1.69304063
25MP0005451_abnormal_body_composition1.69254242
26MP0003718_maternal_effect1.67894274
27MP0000955_abnormal_spinal_cord1.55836191
28MP0003690_abnormal_glial_cell1.54909663
29MP0008875_abnormal_xenobiotic_pharmacok1.52289911
30MP0001529_abnormal_vocalization1.50004735
31MP0000462_abnormal_digestive_system1.44441104
32MP0005083_abnormal_biliary_tract1.39001358
33MP0003329_amyloid_beta_deposits1.38439420
34MP0003122_maternal_imprinting1.34403921
35MP0005646_abnormal_pituitary_gland1.33948907
36MP0010368_abnormal_lymphatic_system1.33620811
37MP0000678_abnormal_parathyroid_gland1.24104811
38MP0005167_abnormal_blood-brain_barrier1.22639068
39MP0005310_abnormal_salivary_gland1.22141862
40MP0003646_muscle_fatigue1.18962234
41MP0005248_abnormal_Harderian_gland1.14849761
42MP0002572_abnormal_emotion/affect_behav1.14603706
43MP0009765_abnormal_xenobiotic_induced1.13033191
44MP0003950_abnormal_plasma_membrane1.11458072
45MP0008877_abnormal_DNA_methylation1.08473993
46MP0002063_abnormal_learning/memory/cond1.06850607
47MP0003861_abnormal_nervous_system1.05228764
48MP0002282_abnormal_trachea_morphology1.03413489
49MP0003787_abnormal_imprinting1.02351684
50MP0003635_abnormal_synaptic_transmissio0.99877806
51MP0001915_intracranial_hemorrhage0.97953778
52MP0003699_abnormal_female_reproductive0.97753230
53MP0003935_abnormal_craniofacial_develop0.94711102
54MP0000537_abnormal_urethra_morphology0.93967542
55MP0010329_abnormal_lipoprotein_level0.93716934
56MP0001119_abnormal_female_reproductive0.91751114
57MP0005253_abnormal_eye_physiology0.90293755
58MP0003806_abnormal_nucleotide_metabolis0.88868085
59MP0002064_seizures0.88657483
60MP0003011_delayed_dark_adaptation0.88094565
61MP0002090_abnormal_vision0.87375302
62MP0003631_nervous_system_phenotype0.87210855
63MP0002249_abnormal_larynx_morphology0.87200213
64MP0004811_abnormal_neuron_physiology0.86780574
65MP0001286_abnormal_eye_development0.86495000
66MP0001440_abnormal_grooming_behavior0.85768722
67MP0009745_abnormal_behavioral_response0.85110442
68MP0004924_abnormal_behavior0.84340563
69MP0005386_behavior/neurological_phenoty0.84340563
70MP0000639_abnormal_adrenal_gland0.83350180
71MP0000604_amyloidosis0.82659576
72MP0002102_abnormal_ear_morphology0.80949458
73MP0000631_abnormal_neuroendocrine_gland0.80076700
74MP0005332_abnormal_amino_acid0.79780383
75MP0009763_increased_sensitivity_to0.79709599
76MP0003632_abnormal_nervous_system0.77789199
77MP0000609_abnormal_liver_physiology0.75482434
78MP0002152_abnormal_brain_morphology0.74659703
79MP0003633_abnormal_nervous_system0.74018312
80MP0003937_abnormal_limbs/digits/tail_de0.73925628
81MP0004270_analgesia0.73716751
82MP0009046_muscle_twitch0.73095879
83MP0000534_abnormal_ureter_morphology0.72556907
84MP0000653_abnormal_sex_gland0.72289353
85MP0004133_heterotaxia0.68336606
86MP0002089_abnormal_postnatal_growth/wei0.68196345
87MP0003755_abnormal_palate_morphology0.65849668
88MP0001324_abnormal_eye_pigmentation0.64920920
89MP0003195_calcinosis0.64248888
90MP0002272_abnormal_nervous_system0.63707736
91MP0002116_abnormal_craniofacial_bone0.62749876
92MP0002184_abnormal_innervation0.60970716
93MP0005187_abnormal_penis_morphology0.60665054
94MP0008874_decreased_physiological_sensi0.60108599
95* MP0002882_abnormal_neuron_morphology0.59932921
96MP0001944_abnormal_pancreas_morphology0.59039610
97MP0001970_abnormal_pain_threshold0.58566717
98MP0002118_abnormal_lipid_homeostasis0.58353621
99MP0003942_abnormal_urinary_system0.57810704
100MP0002210_abnormal_sex_determination0.56476920

Predicted human phenotypes

RankGene SetZ-score
1Peritonitis (HP:0002586)6.26637676
2Abnormality of the lower motor neuron (HP:0002366)5.66773804
3Menstrual irregularities (HP:0000858)4.98699305
4Broad palm (HP:0001169)4.86687042
5Anomalous pulmonary venous return (HP:0010772)4.40663563
6Shawl scrotum (HP:0000049)4.27605438
7Growth hormone excess (HP:0000845)4.25050846
8Oligodactyly (hands) (HP:0001180)4.21325549
9Abnormality of the pulmonary veins (HP:0011718)3.76900668
10Congenital malformation of the right heart (HP:0011723)3.76288552
11Double outlet right ventricle (HP:0001719)3.76288552
12Papillary thyroid carcinoma (HP:0002895)3.76154129
13Mild short stature (HP:0003502)3.75042280
14Deep venous thrombosis (HP:0002625)3.70454610
15Vitreoretinal degeneration (HP:0000655)3.60839286
16Overlapping toe (HP:0001845)3.51158722
17Supernumerary spleens (HP:0009799)3.49574497
18Irregular epiphyses (HP:0010582)3.46602319
19Upper motor neuron abnormality (HP:0002127)3.43891911
20Amyotrophic lateral sclerosis (HP:0007354)3.39898388
21Spontaneous abortion (HP:0005268)3.39853856
22Hepatocellular carcinoma (HP:0001402)3.39739087
23Fair hair (HP:0002286)3.36293566
24Hypoplasia of the odontoid process (HP:0003311)3.34316577
25Chorioretinal atrophy (HP:0000533)3.30757952
26Intrahepatic cholestasis (HP:0001406)3.28475944
27Broad alveolar ridges (HP:0000187)3.09451781
28Congenital stationary night blindness (HP:0007642)3.06425632
29Shoulder girdle muscle weakness (HP:0003547)3.03920511
30Large earlobe (HP:0009748)3.00914471
31Hypercholesterolemia (HP:0003124)3.00822136
32Abnormality of lateral ventricle (HP:0030047)2.96085810
33Asplenia (HP:0001746)2.95965442
34Myocardial infarction (HP:0001658)2.95453331
35Enlarged kidneys (HP:0000105)2.92066792
36High anterior hairline (HP:0009890)2.90931294
37Abnormality of the odontoid process (HP:0003310)2.80304492
38Facial hemangioma (HP:0000329)2.70158810
39Abnormality of the peritoneum (HP:0002585)2.64168082
40Epidermoid cyst (HP:0200040)2.63498203
41Oligodactyly (HP:0012165)2.60960075
42Preauricular pit (HP:0004467)2.58373233
43Periauricular skin pits (HP:0100277)2.58373233
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.58233740
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.55069410
46Bronchomalacia (HP:0002780)2.52111222
47Gastrointestinal infarctions (HP:0005244)2.48078588
48Hyperphosphatemia (HP:0002905)2.41448221
49Generalized hypopigmentation of hair (HP:0011358)2.35779899
50Bony spicule pigmentary retinopathy (HP:0007737)2.30621592
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29548328
52Hypobetalipoproteinemia (HP:0003563)2.20308038
53Abnormality of methionine metabolism (HP:0010901)2.17512403
54Abnormality of the pubic bones (HP:0003172)2.15605405
55Rimmed vacuoles (HP:0003805)2.13827335
56Ulnar deviation of the wrist (HP:0003049)2.08550179
57Onycholysis (HP:0001806)2.05652476
58Cerebral hemorrhage (HP:0001342)2.05064964
59Agitation (HP:0000713)2.04275619
60Dislocated radial head (HP:0003083)2.03810298
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03344452
62Elevated erythrocyte sedimentation rate (HP:0003565)2.00787392
63Abnormal lung lobation (HP:0002101)1.99724207
64Hypoglycemic seizures (HP:0002173)1.98895345
65Central scotoma (HP:0000603)1.97642975
66Morphological abnormality of the middle ear (HP:0008609)1.97469170
67Hyperlipoproteinemia (HP:0010980)1.94832243
68Truncus arteriosus (HP:0001660)1.94230787
69Abnormality of chromosome segregation (HP:0002916)1.94129943
70Hypochromic microcytic anemia (HP:0004840)1.91930165
71Carpal bone hypoplasia (HP:0001498)1.90852137
72Breast aplasia (HP:0100783)1.89853061
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.89225748
74Thyroid carcinoma (HP:0002890)1.89074899
75Fibular hypoplasia (HP:0003038)1.88909775
76Truncal obesity (HP:0001956)1.88586944
77Heterotopia (HP:0002282)1.88490455
78Abnormality of calcium-phosphate metabolism (HP:0100530)1.88433864
79Hypolipoproteinemia (HP:0010981)1.86160206
80Abnormality of the radial head (HP:0003995)1.85414889
81Abolished electroretinogram (ERG) (HP:0000550)1.84787368
82Leiomyosarcoma (HP:0100243)1.83924919
83Uterine leiomyosarcoma (HP:0002891)1.83924919
84Delayed puberty (HP:0000823)1.82436645
85Hypoalphalipoproteinemia (HP:0003233)1.82283514
86Progressive cerebellar ataxia (HP:0002073)1.81159040
87Complement deficiency (HP:0004431)1.79003338
88Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78287090
89Vertebral arch anomaly (HP:0008438)1.76698997
90Xanthomatosis (HP:0000991)1.76319964
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.75716505
92Hyperventilation (HP:0002883)1.75434694
93Flat acetabular roof (HP:0003180)1.74154440
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72617346
95Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70690815
96Abnormality of the nasal septum (HP:0000419)1.70526363
97Gastroesophageal reflux (HP:0002020)1.70408602
98Limb hypertonia (HP:0002509)1.68767122
99Pulmonary artery stenosis (HP:0004415)1.68199802
100Aplasia/Hypoplasia of the breasts (HP:0010311)1.68112524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K65.23651909
2MAP3K53.51433774
3PNCK2.72194754
4CDK122.06221594
5TAOK212.7656619
6MAP3K81.86457713
7STK38L1.77616983
8WNK11.70180208
9DMPK1.54424342
10MAP3K61.42316775
11PRPF4B1.40028553
12PRKD31.35993750
13DDR21.29943611
14ERBB41.24495878
15LATS21.20547657
16BMPR1B1.16984353
17MINK11.08758497
18MST41.00986282
19LATS11.00344768
20CDK90.97466427
21TTK0.96354751
22SGK2230.95928017
23SGK4940.95928017
24JAK30.93310677
25PINK10.91822110
26PDPK10.91064274
27SGK20.85366492
28DYRK1B0.82734889
29MARK10.82539068
30PDK10.79832218
31TAOK30.77628003
32PRKD20.77134206
33FES0.75387251
34INSRR0.73918149
35PLK40.72516921
36CDK80.71547745
37ROCK10.70901580
38BRD40.70857599
39WEE10.68254880
40EPHB20.66672011
41CAMK2A0.64697875
42TGFBR10.57504489
43PLK20.56019623
44SGK30.52993866
45ZAK0.52019539
46MAP2K40.51699986
47STK380.50839533
48MUSK0.49440246
49SIK10.48412580
50PKN10.46150334
51PRKAA20.45226210
52FGR0.45116273
53GRK10.43731222
54CHEK20.40962809
55CDK190.40682104
56MAPK80.37666042
57PRKCH0.36655787
58SGK10.33404071
59TYRO30.32356778
60EEF2K0.31933261
61MAP3K90.30578944
62ROCK20.30565043
63STK100.30354811
64JAK20.28488662
65CAMK1D0.28422978
66PLK10.27485511
67EPHA20.26175870
68MAPK100.25826858
69DYRK20.24138616
70MAPKAPK50.24097583
71OXSR10.23533853
72PDK40.22953588
73PDK30.22953588
74YES10.22639798
75PLK30.22579452
76MAPK130.21559732
77CDK70.21428496
78PAK60.20508997
79CSNK1E0.20435843
80ABL20.19306157
81CDK10.18633307
82KSR10.17603295
83CSNK1D0.17419458
84PRKCQ0.17382718
85MAPK10.17125526
86KSR20.16905671
87PRKCB0.16720284
88NTRK10.16284346
89BRAF0.14725102
90CDC42BPA0.14637803
91MAPK40.14600785
92MATK0.14483426
93CSNK1G20.13906562
94PRKAA10.13905823
95RPS6KA30.13394604
96IGF1R0.13060154
97PRKCG0.12211156
98ABL10.11678098
99EPHA40.11193341
100TIE10.11049795

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.26964762
2Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.90810159
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.85430409
4Arginine biosynthesis_Homo sapiens_hsa002202.58658697
5Vitamin B6 metabolism_Homo sapiens_hsa007502.39255066
6Nicotine addiction_Homo sapiens_hsa050332.38850438
7Dorso-ventral axis formation_Homo sapiens_hsa043202.28974347
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23615636
9Phenylalanine metabolism_Homo sapiens_hsa003602.15291000
10Nitrogen metabolism_Homo sapiens_hsa009102.07589298
11Steroid biosynthesis_Homo sapiens_hsa001002.06448986
12Complement and coagulation cascades_Homo sapiens_hsa046102.05786596
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98940160
14Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.83843272
15Ovarian steroidogenesis_Homo sapiens_hsa049131.79520382
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.70704767
17Histidine metabolism_Homo sapiens_hsa003401.56656980
18Tryptophan metabolism_Homo sapiens_hsa003801.55345466
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50502875
20GnRH signaling pathway_Homo sapiens_hsa049121.50414702
21Prion diseases_Homo sapiens_hsa050201.42185914
22beta-Alanine metabolism_Homo sapiens_hsa004101.41222928
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38006237
24PPAR signaling pathway_Homo sapiens_hsa033201.30793274
25Tyrosine metabolism_Homo sapiens_hsa003501.29466884
26Retinol metabolism_Homo sapiens_hsa008301.27571371
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22664601
28Long-term depression_Homo sapiens_hsa047301.20564351
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20186518
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19676947
31Butanoate metabolism_Homo sapiens_hsa006501.19550353
32Lysine degradation_Homo sapiens_hsa003101.17276511
33ABC transporters_Homo sapiens_hsa020101.16228332
34Bile secretion_Homo sapiens_hsa049761.11633336
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10122759
36Arginine and proline metabolism_Homo sapiens_hsa003301.04067605
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01496361
38Cocaine addiction_Homo sapiens_hsa050300.99930390
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95271399
40Peroxisome_Homo sapiens_hsa041460.95059903
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94402064
42Selenocompound metabolism_Homo sapiens_hsa004500.93760124
43Glutamatergic synapse_Homo sapiens_hsa047240.93625983
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93012221
45Fatty acid degradation_Homo sapiens_hsa000710.92813712
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90327426
47Phototransduction_Homo sapiens_hsa047440.86461490
48Linoleic acid metabolism_Homo sapiens_hsa005910.86295335
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85693851
50Starch and sucrose metabolism_Homo sapiens_hsa005000.84791950
51Amphetamine addiction_Homo sapiens_hsa050310.83862099
52Long-term potentiation_Homo sapiens_hsa047200.81484133
53Staphylococcus aureus infection_Homo sapiens_hsa051500.81161510
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80989363
55TNF signaling pathway_Homo sapiens_hsa046680.80275201
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.77612920
57Rap1 signaling pathway_Homo sapiens_hsa040150.75182434
58Chemical carcinogenesis_Homo sapiens_hsa052040.72530455
59MAPK signaling pathway_Homo sapiens_hsa040100.67538660
60Vitamin digestion and absorption_Homo sapiens_hsa049770.66133770
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65737929
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65121983
63Circadian entrainment_Homo sapiens_hsa047130.64315541
64Oocyte meiosis_Homo sapiens_hsa041140.63803378
65RNA degradation_Homo sapiens_hsa030180.63605379
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.63481201
67Notch signaling pathway_Homo sapiens_hsa043300.61870953
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61136643
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59432315
70GABAergic synapse_Homo sapiens_hsa047270.59290524
71Morphine addiction_Homo sapiens_hsa050320.55732727
72Axon guidance_Homo sapiens_hsa043600.55178541
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53290108
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52748990
75Fatty acid metabolism_Homo sapiens_hsa012120.50942923
76Biosynthesis of amino acids_Homo sapiens_hsa012300.46877130
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45345985
78cAMP signaling pathway_Homo sapiens_hsa040240.45162351
79Ether lipid metabolism_Homo sapiens_hsa005650.44461416
80Cell cycle_Homo sapiens_hsa041100.43792088
81FoxO signaling pathway_Homo sapiens_hsa040680.38423896
82Fatty acid biosynthesis_Homo sapiens_hsa000610.37845038
83Synaptic vesicle cycle_Homo sapiens_hsa047210.37658268
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37496976
85Sulfur metabolism_Homo sapiens_hsa009200.36967417
86Serotonergic synapse_Homo sapiens_hsa047260.35289007
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34870119
88Cholinergic synapse_Homo sapiens_hsa047250.34263945
89MicroRNAs in cancer_Homo sapiens_hsa052060.29911343
90Dilated cardiomyopathy_Homo sapiens_hsa054140.29384121
91Prolactin signaling pathway_Homo sapiens_hsa049170.28082215
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26565838
93Dopaminergic synapse_Homo sapiens_hsa047280.26068208
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26020071
95Basal cell carcinoma_Homo sapiens_hsa052170.24796572
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24430148
97Sphingolipid metabolism_Homo sapiens_hsa006000.24327874
98Folate biosynthesis_Homo sapiens_hsa007900.24309834
99Toxoplasmosis_Homo sapiens_hsa051450.24129676
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.23155610

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