ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of epithelial cell polarity (GO:0090162)	7.09242573
2	pyrimidine nucleobase catabolic process (GO:0006208)	6.68639496
3	negative regulation of DNA-dependent DNA replication (GO:2000104)	6.52910507
4	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	5.97780951
5	iron coordination entity transport (GO:1901678)	5.72141909
6	protein polyglutamylation (GO:0018095)	5.44557976
7	nucleobase catabolic process (GO:0046113)	5.36039278
8	detection of temperature stimulus involved in sensory perception (GO:0050961)	5.11837590
9	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	5.11837590
10	very-low-density lipoprotein particle assembly (GO:0034379)	5.06543773
11	startle response (GO:0001964)	4.62584619
12	oxidative demethylation (GO:0070989)	4.60327356
13	axonemal dynein complex assembly (GO:0070286)	4.51261648
14	one-carbon compound transport (GO:0019755)	4.47029413
15	positive regulation of mitochondrial fission (GO:0090141)	4.44902611
16	ubiquinone biosynthetic process (GO:0006744)	4.44732289
17	protein K6-linked ubiquitination (GO:0085020)	4.37883482
18	negative regulation of cell cycle arrest (GO:0071157)	4.29317581
19	protein neddylation (GO:0045116)	4.25277821
20	ubiquinone metabolic process (GO:0006743)	3.97832683
21	peptide catabolic process (GO:0043171)	3.96016822
22	retinal cone cell development (GO:0046549)	3.69692123
23	response to acidic pH (GO:0010447)	3.68705639
24	regulation of action potential (GO:0098900)	3.66644418
25	detection of temperature stimulus (GO:0016048)	3.66417406
26	response to redox state (GO:0051775)	3.62356489
27	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.58421028
28	heparin biosynthetic process (GO:0030210)	3.50961346
29	heparin metabolic process (GO:0030202)	3.50961346
30	quinone biosynthetic process (GO:1901663)	3.50724460
31	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.47410211
32	arginine catabolic process (GO:0006527)	3.43563796
33	protein complex biogenesis (GO:0070271)	3.41396377
34	notochord development (GO:0030903)	3.35759250
35	regulation of protein polyubiquitination (GO:1902914)	3.34572727
36	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.32213714
37	GTP biosynthetic process (GO:0006183)	3.29455903
38	regulation of ARF protein signal transduction (GO:0032012)	3.26950928
39	establishment of mitochondrion localization (GO:0051654)	3.26084952
40	intraciliary transport (GO:0042073)	3.24628686
41	replication fork processing (GO:0031297)	3.22413963
42	dopamine transport (GO:0015872)	3.20730475
43	regulation of DNA-dependent DNA replication (GO:0090329)	3.20644576
44	uterus development (GO:0060065)	3.20021801
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13709314
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13709314
47	NADH dehydrogenase complex assembly (GO:0010257)	3.13709314
48	regulation of centrosome duplication (GO:0010824)	3.11879725
49	layer formation in cerebral cortex (GO:0021819)	3.06425261
50	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.06204022
51	calcium ion-dependent exocytosis (GO:0017156)	3.04375817
52	axon extension (GO:0048675)	3.04192567
53	regulation of axon extension involved in axon guidance (GO:0048841)	3.04127334
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03418538
55	mitochondrion degradation (GO:0000422)	3.02341588
56	regulation of centrosome cycle (GO:0046605)	3.00549896
57	UTP biosynthetic process (GO:0006228)	2.99428760
58	regulation of mitochondrial fission (GO:0090140)	2.98995427
59	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.97115880
60	retina layer formation (GO:0010842)	2.91733163
61	DNA demethylation (GO:0080111)	2.91560416
62	nitric oxide biosynthetic process (GO:0006809)	2.91254121
63	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.89911524
64	mitochondrion transport along microtubule (GO:0047497)	2.89911524
65	regulation of axon guidance (GO:1902667)	2.86420490
66	neuron projection extension (GO:1990138)	2.84288983
67	positive regulation of growth hormone secretion (GO:0060124)	2.84087389
68	regulation of glucokinase activity (GO:0033131)	2.82274854
69	regulation of hexokinase activity (GO:1903299)	2.82274854
70	neuronal action potential propagation (GO:0019227)	2.80597955
71	hindbrain development (GO:0030902)	2.79440032
72	endocytic recycling (GO:0032456)	2.72887126
73	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.72398171
74	cerebral cortex radially oriented cell migration (GO:0021799)	2.72046759
75	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.67921462
76	behavioral response to nicotine (GO:0035095)	2.67268121
77	regulation of oxidative stress-induced neuron death (GO:1903203)	2.66899169
78	protein K11-linked deubiquitination (GO:0035871)	2.65173069
79	male meiosis (GO:0007140)	2.62872096
80	regulation of dopamine secretion (GO:0014059)	2.62248685
81	protein heterotetramerization (GO:0051290)	2.61848652
82	synaptic vesicle maturation (GO:0016188)	2.61406337
83	regulation of telomere maintenance (GO:0032204)	2.58941406
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.58888981
85	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.58464028
86	positive regulation of axon extension (GO:0045773)	2.58096410
87	catecholamine transport (GO:0051937)	2.56208334
88	UTP metabolic process (GO:0046051)	2.53203393
89	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.51079713
90	cell proliferation in forebrain (GO:0021846)	2.49520459
91	synaptic transmission, glutamatergic (GO:0035249)	2.48392198
92	negative regulation of axon guidance (GO:1902668)	2.47139225
93	replicative senescence (GO:0090399)	2.46494050
94	synaptic transmission, cholinergic (GO:0007271)	2.46366039
95	arginine metabolic process (GO:0006525)	2.44141404
96	positive regulation of action potential (GO:0045760)	2.43842921
97	establishment of nucleus localization (GO:0040023)	2.41979861
98	establishment of cell polarity (GO:0030010)	2.41366302
99	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.40199020
100	response to pheromone (GO:0019236)	12.7530323

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.77279996
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.75858787
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.19593592
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.08253775
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.07892756
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99856710
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56710711
8	TP53_16413492_ChIP-PET_HCT116_Human	2.49348889
9	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.44403706
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22520868
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19847594
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15894721
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13400421
14	FUS_26573619_Chip-Seq_HEK293_Human	2.13271619
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09679620
16	AHR_22903824_ChIP-Seq_MCF-7_Human	1.96025370
17	EWS_26573619_Chip-Seq_HEK293_Human	1.93962438
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87918802
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.86672730
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.79997346
21	VDR_22108803_ChIP-Seq_LS180_Human	1.79769356
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.69865011
23	P300_19829295_ChIP-Seq_ESCs_Human	1.66668621
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64380600
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64225182
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64225182
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.61277291
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59529012
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58662820
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57463555
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55611522
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.55587484
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54224336
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51139208
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45131471
36	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.44041010
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.42622597
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41116405
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40957796
40	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.38369107
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36949677
42	SOX9_26525672_Chip-Seq_HEART_Mouse	1.34479152
43	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33412790
44	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.32031670
45	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.31078260
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30629429
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30540122
48	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.28192360
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28055484
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26208067
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26073307
52	STAT3_23295773_ChIP-Seq_U87_Human	1.24550402
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23073990
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.23056695
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22789464
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22244239
57	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.21124080
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.20665531
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20545741
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19592852
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18168909
62	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.15956270
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15064871
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14130000
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13943588
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13730248
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13292727
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13202640
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11655142
70	TAF15_26573619_Chip-Seq_HEK293_Human	1.11157692
71	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.10806094
72	TCF4_23295773_ChIP-Seq_U87_Human	1.10419738
73	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.10260248
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.09541042
75	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.09540704
76	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07284759
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06574437
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06556167
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06257834
80	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.04955000
81	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.04807345
82	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.03969242
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.03663470
84	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.02828067
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01470460
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01237907
87	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.00639141
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99355926
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.99355059
90	MYC_18940864_ChIP-ChIP_HL60_Human	0.99051802
91	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.98347044
92	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.97910888
93	AR_25329375_ChIP-Seq_VCAP_Human	0.97576145
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95807378
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95178283
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95119719
97	TBL1_22424771_ChIP-Seq_293T_Human	0.93795206
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93486478
99	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92573036
100	CBP_20019798_ChIP-Seq_JUKART_Human	0.91663205

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.60690598
2	MP0005423_abnormal_somatic_nervous	4.01529009
3	MP0003787_abnormal_imprinting	3.48813931
4	MP0006072_abnormal_retinal_apoptosis	3.34954665
5	MP0003121_genomic_imprinting	3.04188205
6	MP0003123_paternal_imprinting	3.00664778
7	MP0002638_abnormal_pupillary_reflex	2.75137134
8	MP0003806_abnormal_nucleotide_metabolis	2.63982994
9	MP0005253_abnormal_eye_physiology	2.52779579
10	MP0003880_abnormal_central_pattern	2.51942605
11	MP0001529_abnormal_vocalization	2.32606792
12	MP0003890_abnormal_embryonic-extraembry	2.12350505
13	MP0002938_white_spotting	2.07927195
14	MP0000778_abnormal_nervous_system	2.02854596
15	MP0006276_abnormal_autonomic_nervous	1.90228818
16	MP0005386_behavior/neurological_phenoty	1.86945252
17	MP0004924_abnormal_behavior	1.86945252
18	MP0004270_analgesia	1.81156589
19	MP0003122_maternal_imprinting	1.80718336
20	MP0010386_abnormal_urinary_bladder	1.78987255
21	MP0002163_abnormal_gland_morphology	1.74191124
22	MP0005623_abnormal_meninges_morphology	1.72999511
23	MP0003283_abnormal_digestive_organ	1.71913357
24	MP0002102_abnormal_ear_morphology	1.68665338
25	MP0003950_abnormal_plasma_membrane	1.68305594
26	MP0002282_abnormal_trachea_morphology	1.66487230
27	MP0002822_catalepsy	1.63193927
28	MP0001485_abnormal_pinna_reflex	1.62959417
29	MP0004885_abnormal_endolymph	1.61892372
30	MP0001299_abnormal_eye_distance/	1.58292169
31	MP0000372_irregular_coat_pigmentation	1.56114484
32	MP0004133_heterotaxia	1.54930661
33	MP0005551_abnormal_eye_electrophysiolog	1.54175055
34	MP0003937_abnormal_limbs/digits/tail_de	1.48479574
35	MP0000647_abnormal_sebaceous_gland	1.46575944
36	MP0000015_abnormal_ear_pigmentation	1.46183851
37	MP0005220_abnormal_exocrine_pancreas	1.44491294
38	MP0005379_endocrine/exocrine_gland_phen	1.42912326
39	MP0002160_abnormal_reproductive_system	1.41834119
40	MP0004484_altered_response_of	1.37479306
41	MP0003195_calcinosis	1.30322839
42	MP0003567_abnormal_fetal_cardiomyocyte	1.26827015
43	MP0005195_abnormal_posterior_eye	1.26544557
44	MP0003119_abnormal_digestive_system	1.23367708
45	MP0003635_abnormal_synaptic_transmissio	1.21272615
46	MP0005391_vision/eye_phenotype	1.18527864
47	MP0001502_abnormal_circadian_rhythm	1.17768666
48	MP0009379_abnormal_foot_pigmentation	1.16598525
49	MP0002184_abnormal_innervation	1.16159635
50	MP0003186_abnormal_redox_activity	1.14424335
51	MP0005408_hypopigmentation	1.13931432
52	MP0002557_abnormal_social/conspecific_i	1.13778380
53	MP0000631_abnormal_neuroendocrine_gland	1.13120355
54	MP0006035_abnormal_mitochondrial_morpho	1.10295098
55	MP0001905_abnormal_dopamine_level	1.08734630
56	MP0002272_abnormal_nervous_system	1.08193157
57	MP0004145_abnormal_muscle_electrophysio	1.07227013
58	MP0004142_abnormal_muscle_tone	1.06760053
59	MP0000955_abnormal_spinal_cord	1.05724838
60	MP0001188_hyperpigmentation	1.01870332
61	MP0000470_abnormal_stomach_morphology	1.01398975
62	MP0002882_abnormal_neuron_morphology	1.01379546
63	MP0000049_abnormal_middle_ear	0.99678350
64	MP0003942_abnormal_urinary_system	0.98068597
65	MP0002752_abnormal_somatic_nervous	0.95631881
66	MP0005174_abnormal_tail_pigmentation	0.93942628
67	MP0005389_reproductive_system_phenotype	0.93780890
68	MP0000566_synostosis	0.92492278
69	MP0004859_abnormal_synaptic_plasticity	0.92380642
70	MP0008877_abnormal_DNA_methylation	0.91932562
71	MP0002063_abnormal_learning/memory/cond	0.91756825
72	MP0006292_abnormal_olfactory_placode	0.90959087
73	MP0002095_abnormal_skin_pigmentation	0.89639849
74	MP0004811_abnormal_neuron_physiology	0.88631743
75	MP0001440_abnormal_grooming_behavior	0.86424819
76	MP0000358_abnormal_cell_content/	0.85661787
77	MP0000427_abnormal_hair_cycle	0.83362077
78	MP0002572_abnormal_emotion/affect_behav	0.81593281
79	MP0005075_abnormal_melanosome_morpholog	0.81567508
80	MP0002734_abnormal_mechanical_nocicepti	0.80772208
81	MP0003959_abnormal_lean_body	0.79972797
82	MP0002653_abnormal_ependyma_morphology	0.78199251
83	MP0003698_abnormal_male_reproductive	0.78189096
84	MP0001293_anophthalmia	0.76740720
85	MP0002067_abnormal_sensory_capabilities	0.76671816
86	MP0002152_abnormal_brain_morphology	0.75140837
87	MP0009745_abnormal_behavioral_response	0.75064187
88	MP0002928_abnormal_bile_duct	0.71003353
89	MP0009250_abnormal_appendicular_skeleto	0.70926699
90	MP0009046_muscle_twitch	0.70458020
91	MP0005266_abnormal_metabolism	0.69722496
92	MP0004742_abnormal_vestibular_system	0.69622031
93	MP0001963_abnormal_hearing_physiology	0.69060243
94	MP0001756_abnormal_urination	0.67789836
95	MP0002109_abnormal_limb_morphology	0.67374011
96	MP0010030_abnormal_orbit_morphology	0.66355164
97	MP0005646_abnormal_pituitary_gland	0.65135399
98	MP0002932_abnormal_joint_morphology	0.64435162
99	MP0008775_abnormal_heart_ventricle	0.64265868
100	MP0002066_abnormal_motor_capabilities/c	0.63610747

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb hypertonia (HP:0002509)	4.78550225
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.61646631
3	Hypoplasia of the fovea (HP:0007750)	4.61646631
4	Abnormality of midbrain morphology (HP:0002418)	3.94829869
5	Molar tooth sign on MRI (HP:0002419)	3.94829869
6	Renal cortical cysts (HP:0000803)	3.76840401
7	Confusion (HP:0001289)	3.67171600
8	Prolonged neonatal jaundice (HP:0006579)	3.54109633
9	Abnormality of the fovea (HP:0000493)	3.54015946
10	Aplasia/Hypoplasia of the macula (HP:0008059)	3.42379148
11	Congenital stationary night blindness (HP:0007642)	3.41072038
12	Abnormal pancreas size (HP:0012094)	3.34280379
13	Volvulus (HP:0002580)	3.30448100
14	Enlarged kidneys (HP:0000105)	3.29843653
15	Bifid tongue (HP:0010297)	3.26050762
16	Tubular atrophy (HP:0000092)	3.15508330
17	Progressive cerebellar ataxia (HP:0002073)	3.14449470
18	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.13589798
19	Anterior segment dysgenesis (HP:0007700)	3.11322456
20	Increased hepatocellular lipid droplets (HP:0006565)	3.09160373
21	Abnormality of the renal cortex (HP:0011035)	2.98376686
22	Protruding tongue (HP:0010808)	2.91432747
23	Genetic anticipation (HP:0003743)	2.90769598
24	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.79345873
25	Lipid accumulation in hepatocytes (HP:0006561)	2.74307249
26	Amelogenesis imperfecta (HP:0000705)	2.73169282
27	Partial duplication of thumb phalanx (HP:0009944)	2.63772576
28	Occipital encephalocele (HP:0002085)	2.56070813
29	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.54295484
30	Drooling (HP:0002307)	2.51399585
31	Hyperglycinemia (HP:0002154)	2.50333989
32	Abnormality of the frontal sinuses (HP:0002687)	2.49917615
33	Absent frontal sinuses (HP:0002688)	2.42048749
34	Reticulocytosis (HP:0001923)	2.38970726
35	Tubulointerstitial nephritis (HP:0001970)	2.34727216
36	Narrow forehead (HP:0000341)	2.32930960
37	Tachypnea (HP:0002789)	2.32714856
38	Partial duplication of the phalanx of hand (HP:0009999)	2.29962539
39	Epileptic encephalopathy (HP:0200134)	2.27302307
40	Increased serum lactate (HP:0002151)	2.26774291
41	Abnormality of the renal medulla (HP:0100957)	2.25986145
42	Pancreatic fibrosis (HP:0100732)	2.24539843
43	Partial agenesis of the corpus callosum (HP:0001338)	2.24006962
44	Excessive salivation (HP:0003781)	2.23920614
45	Diastasis recti (HP:0001540)	2.23761888
46	Hepatic necrosis (HP:0002605)	2.21774565
47	Hyperventilation (HP:0002883)	2.21408458
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20209960
49	Abnormality of alanine metabolism (HP:0010916)	2.20209960
50	Hyperalaninemia (HP:0003348)	2.20209960
51	Rectal fistula (HP:0100590)	2.16554039
52	Rectovaginal fistula (HP:0000143)	2.16554039
53	Hypoglycemic coma (HP:0001325)	2.16503542
54	Hypochromic microcytic anemia (HP:0004840)	2.16285249
55	Medial flaring of the eyebrow (HP:0010747)	2.14941449
56	Nephronophthisis (HP:0000090)	2.14070300
57	Neoplasm of the adrenal cortex (HP:0100641)	2.13175056
58	Chronic hepatic failure (HP:0100626)	2.12811193
59	Febrile seizures (HP:0002373)	2.11753477
60	Glycosuria (HP:0003076)	2.10734133
61	Abnormality of urine glucose concentration (HP:0011016)	2.10734133
62	Atonic seizures (HP:0010819)	2.10494978
63	Hepatoblastoma (HP:0002884)	2.10241636
64	Delayed CNS myelination (HP:0002188)	2.08492470
65	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06349203
66	Acute encephalopathy (HP:0006846)	2.04344707
67	Status epilepticus (HP:0002133)	2.03864675
68	Focal seizures (HP:0007359)	2.03693385
69	Renal Fanconi syndrome (HP:0001994)	2.03162217
70	Highly arched eyebrow (HP:0002553)	2.03060618
71	Metaphyseal dysplasia (HP:0100255)	2.02952019
72	Respiratory distress (HP:0002098)	1.98027580
73	Macroglossia (HP:0000158)	1.93434002
74	Poikilocytosis (HP:0004447)	1.91822876
75	Open mouth (HP:0000194)	1.91655539
76	Aganglionic megacolon (HP:0002251)	1.90704592
77	Intellectual disability, severe (HP:0010864)	1.89126073
78	True hermaphroditism (HP:0010459)	1.88386644
79	Large eyes (HP:0001090)	1.87995519
80	Increased intramyocellular lipid droplets (HP:0012240)	1.87246964
81	Nephrogenic diabetes insipidus (HP:0009806)	1.86557986
82	Pancreatic cysts (HP:0001737)	1.86005955
83	Pachygyria (HP:0001302)	1.85902548
84	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84340962
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84340962
86	Increased CSF lactate (HP:0002490)	1.84269707
87	Hyperthyroidism (HP:0000836)	1.83012155
88	Synostosis involving the elbow (HP:0003938)	1.82297778
89	Humeroradial synostosis (HP:0003041)	1.82297778
90	Inability to walk (HP:0002540)	1.82003072
91	Hyperphosphaturia (HP:0003109)	1.81869863
92	Abnormality of reticulocytes (HP:0004312)	1.81514041
93	Small hand (HP:0200055)	1.81258961
94	Peritonitis (HP:0002586)	1.80171362
95	Abnormality of the phalanges of the hallux (HP:0010057)	1.80102644
96	Cortical dysplasia (HP:0002539)	1.78921287
97	Mitochondrial inheritance (HP:0001427)	1.78731564
98	Esotropia (HP:0000565)	1.78260596
99	EEG with generalized epileptiform discharges (HP:0011198)	1.78225309
100	Gait imbalance (HP:0002141)	1.78211759

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.48865335
2	MAP4K2	4.41170101
3	CDK9	3.93343963
4	WNK1	3.18190164
5	BMPR1B	2.71430542
6	DDR2	2.65496745
7	STK16	2.47403736
8	ZAK	2.31652644
9	WNK3	2.12176348
10	DYRK2	2.09323535
11	FRK	1.89038321
12	AKT3	1.86121518
13	MAP3K7	1.77863397
14	PDK2	1.75478876
15	MAP3K6	1.65508218
16	NTRK2	1.63543388
17	MKNK2	1.63368126
18	MAP3K4	1.42515929
19	DYRK3	1.42087163
20	MARK1	1.42072950
21	CDC42BPA	1.40062144
22	ACVR1B	1.39441988
23	SGK494	1.35792013
24	SGK223	1.35792013
25	TYRO3	1.35173188
26	NEK2	1.27394904
27	STK38L	1.25175394
28	MAP2K7	1.17998829
29	NUAK1	1.17659881
30	PRKCG	1.09794679
31	PKN1	1.08985501
32	CDK8	1.06948149
33	GRK1	1.06441982
34	BUB1	1.04685898
35	TGFBR1	1.03790089
36	TAOK3	1.00735825
37	BRD4	1.00376960
38	VRK1	0.99520660
39	PRKCH	0.99280681
40	SGK3	0.92183120
41	MAPK11	0.88645118
42	ATR	0.88643691
43	TAF1	0.87514433
44	STK11	0.87352952
45	ADRBK1	0.84959977
46	PIK3CA	0.83133241
47	BRAF	0.82274890
48	SGK2	0.81407125
49	MINK1	0.80404373
50	PASK	0.78955117
51	OBSCN	0.74037047
52	EPHA4	0.73970894
53	PAK3	0.72791630
54	TTK	0.71650698
55	PBK	0.70195229
56	BCR	0.67566380
57	ADRBK2	0.66658069
58	DYRK1B	0.65850304
59	STK39	0.64822796
60	MKNK1	0.64330735
61	CAMK4	0.61532518
62	OXSR1	0.61327059
63	WEE1	0.60929377
64	CDK5	0.59472091
65	ERBB3	0.59394710
66	BCKDK	0.58097511
67	AURKB	0.57825946
68	CAMK1	0.57679690
69	PTK2B	0.55143472
70	CHEK2	0.54650119
71	MAP2K4	0.54248487
72	TIE1	0.53953315
73	NEK6	0.50952224
74	STK3	0.50599826
75	PLK2	0.48484802
76	MATK	0.47432158
77	ICK	0.47180825
78	STK10	0.45342688
79	PLK4	0.45150441
80	CAMKK2	0.44851909
81	PRKD2	0.43961219
82	CHEK1	0.43544944
83	ATM	0.43157270
84	PRKCQ	0.42831196
85	AKT1	0.39454679
86	ARAF	0.38953414
87	PLK3	0.38857651
88	CASK	0.37503217
89	PRKCZ	0.37201637
90	CAMK2A	0.36277490
91	PRKG1	0.35795901
92	STK4	0.35751697
93	PRKAA1	0.35069834
94	PDGFRA	0.34730972
95	PIM1	0.34539455
96	CSNK1G2	0.33393171
97	CSNK1E	0.32410745
98	ABL1	0.32410514
99	SGK1	0.31831370
100	LATS1	0.31668588

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	5.06204857
2	Sulfur relay system_Homo sapiens_hsa04122	2.79302933
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.70731851
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.69127769
5	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.42392740
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.33530145
7	Parkinsons disease_Homo sapiens_hsa05012	2.20938263
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.17146505
9	Alzheimers disease_Homo sapiens_hsa05010	1.93877498
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83680392
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.81843243
12	Nicotine addiction_Homo sapiens_hsa05033	1.77753850
13	Cocaine addiction_Homo sapiens_hsa05030	1.62476902
14	Basal transcription factors_Homo sapiens_hsa03022	1.60411419
15	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.59259470
16	Propanoate metabolism_Homo sapiens_hsa00640	1.58486785
17	Butanoate metabolism_Homo sapiens_hsa00650	1.54729274
18	Ribosome_Homo sapiens_hsa03010	1.52269427
19	Huntingtons disease_Homo sapiens_hsa05016	1.51028101
20	Peroxisome_Homo sapiens_hsa04146	1.47211644
21	Amphetamine addiction_Homo sapiens_hsa05031	1.41722428
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39399533
23	Alcoholism_Homo sapiens_hsa05034	1.39394422
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.38497323
25	Protein export_Homo sapiens_hsa03060	1.37748756
26	Lysine degradation_Homo sapiens_hsa00310	1.36436126
27	Insulin secretion_Homo sapiens_hsa04911	1.36049513
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34786279
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32128468
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26883784
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25105868
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.23197181
33	Sulfur metabolism_Homo sapiens_hsa00920	1.19695634
34	Homologous recombination_Homo sapiens_hsa03440	1.19136867
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14596364
36	Dopaminergic synapse_Homo sapiens_hsa04728	1.10486682
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.07988636
38	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.06712299
39	Renin secretion_Homo sapiens_hsa04924	1.04578928
40	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.02761690
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.99996418
42	GABAergic synapse_Homo sapiens_hsa04727	0.96750804
43	Axon guidance_Homo sapiens_hsa04360	0.95727591
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.93782119
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92563683
46	Cholinergic synapse_Homo sapiens_hsa04725	0.92261140
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.90577931
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.86744940
49	Morphine addiction_Homo sapiens_hsa05032	0.86318579
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.85843117
51	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.84380667
52	Phototransduction_Homo sapiens_hsa04744	0.81549821
53	Gap junction_Homo sapiens_hsa04540	0.81262267
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79626218
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78264075
56	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.77801640
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.77502624
58	RNA degradation_Homo sapiens_hsa03018	0.76372747
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.72994234
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72655297
61	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.69837723
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69623322
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.66322747
64	Circadian entrainment_Homo sapiens_hsa04713	0.66127591
65	Gastric acid secretion_Homo sapiens_hsa04971	0.66049128
66	RNA polymerase_Homo sapiens_hsa03020	0.64821169
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64805037
68	VEGF signaling pathway_Homo sapiens_hsa04370	0.64441910
69	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.64434646
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.64139670
71	Long-term potentiation_Homo sapiens_hsa04720	0.63343538
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.62622782
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.60710837
74	Salivary secretion_Homo sapiens_hsa04970	0.59571264
75	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.58787057
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55123057
77	p53 signaling pathway_Homo sapiens_hsa04115	0.54471572
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53720710
79	Tight junction_Homo sapiens_hsa04530	0.52889872
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52831157
81	Olfactory transduction_Homo sapiens_hsa04740	0.51925572
82	Metabolic pathways_Homo sapiens_hsa01100	0.50297374
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49849700
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49760470
85	Wnt signaling pathway_Homo sapiens_hsa04310	0.49143719
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.48966657
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.48557735
88	Serotonergic synapse_Homo sapiens_hsa04726	0.48122626
89	Long-term depression_Homo sapiens_hsa04730	0.47557825
90	Taste transduction_Homo sapiens_hsa04742	0.46589174
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46063671
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45223113
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43494289
94	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42957654
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41568038
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.40937153
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.39365253
98	Oocyte meiosis_Homo sapiens_hsa04114	0.39089509
99	Melanogenesis_Homo sapiens_hsa04916	0.36572677
100	Retinol metabolism_Homo sapiens_hsa00830	0.36226209

GJA1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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