GJA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.04887783
2myofibril assembly (GO:0030239)9.04787556
3response to muscle activity (GO:0014850)8.02167079
4lens morphogenesis in camera-type eye (GO:0002089)7.09940810
5cardiac myofibril assembly (GO:0055003)6.52186649
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.46710138
7muscle cell cellular homeostasis (GO:0046716)6.35584102
8relaxation of cardiac muscle (GO:0055119)6.18945758
9negative regulation of potassium ion transmembrane transport (GO:1901380)6.08167371
10cardiac chamber formation (GO:0003207)5.81569171
11histone H3-K9 demethylation (GO:0033169)5.50223119
12desmosome organization (GO:0002934)5.45539657
13actomyosin structure organization (GO:0031032)5.41881723
14camera-type eye development (GO:0043010)5.41015038
15atrial septum morphogenesis (GO:0060413)5.36666144
16* visual perception (GO:0007601)5.14224598
17cellular response to osmotic stress (GO:0071470)5.09674089
18* sensory perception of light stimulus (GO:0050953)5.07466440
19sequestering of extracellular ligand from receptor (GO:0035581)5.05065206
20cytolysis (GO:0019835)4.79896379
21protein refolding (GO:0042026)4.79052872
22cardiac ventricle formation (GO:0003211)4.69664062
23ventricular cardiac muscle cell action potential (GO:0086005)4.69102724
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.68024590
25regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.61834149
26cardiac muscle cell development (GO:0055013)4.52652267
27outflow tract septum morphogenesis (GO:0003148)4.47622838
28cardiac muscle contraction (GO:0060048)4.47309670
29cardiac cell development (GO:0055006)4.37265208
30bone trabecula formation (GO:0060346)4.32074021
31carnitine shuttle (GO:0006853)4.31555021
32plasma membrane repair (GO:0001778)4.30994789
33eye development (GO:0001654)4.27929405
34atrioventricular valve morphogenesis (GO:0003181)4.23396092
35embryonic heart tube development (GO:0035050)4.23008928
36regulation of protein sumoylation (GO:0033233)4.21597843
37ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.19234176
38regulation of ATPase activity (GO:0043462)4.15700843
39regulation of ATP catabolic process (GO:1903289)4.15700843
40regulation of sarcomere organization (GO:0060297)4.15571060
41insulin-like growth factor receptor signaling pathway (GO:0048009)4.12698587
42regulation of cardioblast differentiation (GO:0051890)4.11322988
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.08142914
44adrenergic receptor signaling pathway (GO:0071875)4.08112919
45cardiac muscle tissue development (GO:0048738)4.05661733
46actin-myosin filament sliding (GO:0033275)4.04399679
47muscle filament sliding (GO:0030049)4.04399679
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.03522463
49regulation of actin filament-based movement (GO:1903115)4.01191647
50regulation of cardioblast proliferation (GO:0003264)4.00857131
51regulation of secondary heart field cardioblast proliferation (GO:0003266)4.00857131
52regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.99464817
53gap junction assembly (GO:0016264)3.97901331
54bundle of His cell to Purkinje myocyte communication (GO:0086069)3.96803675
55negative regulation of myotube differentiation (GO:0010832)3.96613354
56cardiac muscle tissue morphogenesis (GO:0055008)3.96509975
57relaxation of muscle (GO:0090075)3.92402100
58bile acid and bile salt transport (GO:0015721)3.81474191
59regulation of glucocorticoid metabolic process (GO:0031943)3.78223714
60positive regulation of cardiac muscle cell differentiation (GO:2000727)3.77481469
61adult heart development (GO:0007512)3.76978654
62regulation of heart contraction (GO:0008016)3.76691621
63regulation of cardiac muscle cell apoptotic process (GO:0010665)3.71157483
64tricarboxylic acid cycle (GO:0006099)3.70704178
65heart trabecula formation (GO:0060347)3.67909776
66regulation of membrane repolarization (GO:0060306)3.66964531
67fatty acid transmembrane transport (GO:1902001)3.65356207
68negative regulation of hormone biosynthetic process (GO:0032353)3.60951329
69cardiac muscle adaptation (GO:0014887)3.59383329
70cardiac muscle hypertrophy in response to stress (GO:0014898)3.59383329
71muscle hypertrophy in response to stress (GO:0003299)3.59383329
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.58619155
73positive regulation of cardiac muscle tissue development (GO:0055025)3.55810815
74cell communication involved in cardiac conduction (GO:0086065)3.55311934
75positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.54166173
76muscle tissue morphogenesis (GO:0060415)3.52776740
77actin-mediated cell contraction (GO:0070252)3.47333687
78sodium ion export (GO:0071436)3.45480075
79regulation of acyl-CoA biosynthetic process (GO:0050812)3.44069817
80positive regulation of heart contraction (GO:0045823)3.41694283
81positive regulation of cardiac muscle cell proliferation (GO:0060045)3.36071491
82regulation of coenzyme metabolic process (GO:0051196)3.34823359
83regulation of cofactor metabolic process (GO:0051193)3.34823359
84pericardium development (GO:0060039)3.33367960
85endocardial cushion morphogenesis (GO:0003203)3.33205181
86glomerular basement membrane development (GO:0032836)3.31005967
87positive regulation of ATP catabolic process (GO:1903291)3.30895499
88positive regulation of ATPase activity (GO:0032781)3.30895499
89regulation of tight junction assembly (GO:2000810)3.29843647
90cell communication by electrical coupling (GO:0010644)3.29632226
91cardiac muscle hypertrophy (GO:0003300)3.29390842
92sensory organ development (GO:0007423)3.28751950
93regulation of myoblast differentiation (GO:0045661)3.28261234
94regulation of relaxation of muscle (GO:1901077)3.27163925
95positive regulation of cardiac muscle tissue growth (GO:0055023)3.26934996
96negative regulation of homotypic cell-cell adhesion (GO:0034111)3.26860885
97striated muscle cell development (GO:0055002)3.24520104
98epithelial cell-cell adhesion (GO:0090136)3.24150479
99positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)3.23921410
100regulation of striated muscle cell apoptotic process (GO:0010662)3.23675328
101relaxation of smooth muscle (GO:0044557)3.22102777
102cardiac muscle cell action potential involved in contraction (GO:0086002)3.18648661
103response to caffeine (GO:0031000)3.18510523
104striated muscle contraction (GO:0006941)3.17730513
105regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.17370901
106regulation of cardiac muscle cell differentiation (GO:2000725)3.14641285
107cardiac muscle cell action potential (GO:0086001)3.13842671
108endocardial cushion development (GO:0003197)3.13515662
109regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.12195199
110negative regulation of cell size (GO:0045792)3.11641328
111negative regulation of potassium ion transport (GO:0043267)3.08850850
112striated muscle hypertrophy (GO:0014897)3.07825366
113regulation of striated muscle contraction (GO:0006942)3.07154219
114regulation of the force of heart contraction (GO:0002026)3.06469492
115carnitine transmembrane transport (GO:1902603)3.06015148
116detection of calcium ion (GO:0005513)3.04807318
117cell migration involved in heart development (GO:0060973)3.02655951
118lens development in camera-type eye (GO:0002088)23.6096381
119regulation of cardiac muscle cell contraction (GO:0086004)2.98195505
120regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.94583501
121negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.92496026
122regulation of skeletal muscle contraction (GO:0014819)2.89930733
123ventricular cardiac muscle cell development (GO:0055015)2.86502463
124glomerular visceral epithelial cell development (GO:0072015)2.86242911
125negative regulation of striated muscle cell apoptotic process (GO:0010664)2.86037092
126trabecula formation (GO:0060343)2.82706140
127sarcoplasmic reticulum calcium ion transport (GO:0070296)2.81449875
128actin filament-based movement (GO:0030048)2.80920786
129response to salt stress (GO:0009651)2.78912829
130amino-acid betaine transport (GO:0015838)2.78567731
131carnitine transport (GO:0015879)2.78567731
132regulation of myotube differentiation (GO:0010830)2.77823172
133regulation of heart rate (GO:0002027)2.77393777
134regulation of heart rate by cardiac conduction (GO:0086091)2.76561831
135regulation of cell communication by electrical coupling (GO:0010649)2.75571791
136apoptotic process involved in morphogenesis (GO:0060561)2.75461622
137potassium ion export (GO:0071435)2.74150421
138regulation of cardiac muscle contraction (GO:0055117)2.72732981
139venous blood vessel morphogenesis (GO:0048845)2.70904898
140basement membrane organization (GO:0071711)2.68416580
141regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66964778
142muscle hypertrophy (GO:0014896)2.65774604
143cardiac conduction (GO:0061337)2.65570965
144regulation of skeletal muscle fiber development (GO:0048742)2.63752892
145membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63096872
146positive regulation of potassium ion transmembrane transport (GO:1901381)2.62574671
147negative regulation of protein localization to cell surface (GO:2000009)2.61840419
148heart contraction (GO:0060047)2.60322395
149heart process (GO:0003015)2.60322395
150lens fiber cell development (GO:0070307)17.3406863
151lens fiber cell differentiation (GO:0070306)13.4157191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.47816107
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.15928025
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.93926023
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10792650
5GATA4_21415370_ChIP-Seq_HL-1_Mouse3.06873431
6AR_21909140_ChIP-Seq_LNCAP_Human2.73528920
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.73281783
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67049755
9TBX20_22080862_ChIP-Seq_HEART_Mouse2.53727514
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.53727514
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.47706525
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42011950
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.39668881
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.37834843
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36501741
16ZNF263_19887448_ChIP-Seq_K562_Human2.32389935
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31768274
18EGR1_19032775_ChIP-ChIP_M12_Human2.29057786
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.22667399
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14474642
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12875290
22EZH2_22144423_ChIP-Seq_EOC_Human2.11392950
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.99571096
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.93952179
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84716910
26CLOCK_20551151_ChIP-Seq_293T_Human1.82849514
27ISL1_27105846_Chip-Seq_CPCs_Mouse1.80236493
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76969212
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75733644
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75733644
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68707705
32MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.67320530
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.66411396
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62536535
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62425924
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.59595771
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.56999131
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55153229
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54824215
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.51094874
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50622213
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.50337507
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.48037746
44CTCF_27219007_Chip-Seq_Bcells_Human1.46292913
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45046959
46BRD4_25478319_ChIP-Seq_HGPS_Human1.45003209
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43723333
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43327382
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41848399
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41166524
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40489012
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.39674744
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38960286
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38474865
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36847708
56TP53_16413492_ChIP-PET_HCT116_Human1.36762939
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36153645
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34664234
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33377860
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33210508
61* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32506810
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31613917
63* GATA3_24758297_ChIP-Seq_MCF-7_Human1.31584144
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29607414
65SMC3_22415368_ChIP-Seq_MEFs_Mouse1.29526164
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29471061
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29099456
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29001960
69CJUN_26792858_Chip-Seq_BT549_Human1.28623325
70GATA1_19941827_ChIP-Seq_MEL86_Mouse1.27094130
71* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26014316
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25806176
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25381132
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24360878
75* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23847735
76* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21901068
77TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21651453
78EED_16625203_ChIP-ChIP_MESCs_Mouse1.21572166
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21566895
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.21467004
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21312737
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21061140
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.21005077
84LXR_22292898_ChIP-Seq_THP-1_Human1.20900366
85KDM2B_26808549_Chip-Seq_K562_Human1.19390186
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.18541237
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18113166
88* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17495954
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.15554381
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14798733
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14439596
92TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14085152
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.13299223
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13176123
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.12906304
96* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12766859
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12053941
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11396120
99KDM2B_26808549_Chip-Seq_DND41_Human1.11347641
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11321695
101* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11159457
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11093213
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10967100
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10967100
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05896326
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03467011
107ATF3_27146783_Chip-Seq_COLON_Human1.03157123
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03076614
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.02837498
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02767787
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02423656
112SMAD3_21741376_ChIP-Seq_HESCs_Human1.02057413
113SOX17_20123909_ChIP-Seq_XEN_Mouse1.01886137
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01511843
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99767131
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99754892
117* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99420322
118ZNF274_21170338_ChIP-Seq_K562_Hela0.99092901
119* RNF2_27304074_Chip-Seq_ESCs_Mouse0.97700299
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97607112
121SOX9_26525672_Chip-Seq_HEART_Mouse0.96692206
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95599081
123* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94883209
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.93995993
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93839511
126TP53_23651856_ChIP-Seq_MEFs_Mouse0.93755045
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.93517108
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93352896
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93352896
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92617026
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91631564
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91381836
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91311417
134JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91189605
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91160495
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91047503
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.90682719
138* GATA2_21666600_ChIP-Seq_HMVEC_Human0.90573940
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.90511917
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90109771
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89783082
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88914050
143* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88606576
144SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88448969
145SOX2_20726797_ChIP-Seq_SW620_Human0.88306247
146EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88107022
147* EZH2_27294783_Chip-Seq_ESCs_Mouse0.87983980
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87932334
149TCF7_22412390_ChIP-Seq_EML_Mouse0.87833052
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.87729763
151TBL1_22424771_ChIP-Seq_293T_Human0.86682066
152REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86463831
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86089603
154SMAD4_21799915_ChIP-Seq_A2780_Human0.85683515
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82686540
156YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82622934
157SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82226386
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82187139
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80124617
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.80122322
161POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80018714
162* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79787193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002697_abnormal_eye_size8.85838531
2* MP0005193_abnormal_anterior_eye5.90450549
3MP0000749_muscle_degeneration4.64391809
4MP0002837_dystrophic_cardiac_calcinosis4.46149077
5MP0004084_abnormal_cardiac_muscle4.36647847
6MP0005330_cardiomyopathy3.64807830
7MP0000751_myopathy3.37724758
8MP0003646_muscle_fatigue3.14609364
9MP0004215_abnormal_myocardial_fiber3.04055594
10MP0004036_abnormal_muscle_relaxation2.92115087
11MP0005253_abnormal_eye_physiology2.89412647
12MP0003941_abnormal_skin_development2.81261373
13MP0005197_abnormal_uvea_morphology2.60411088
14MP0004087_abnormal_muscle_fiber2.47401303
15MP0001286_abnormal_eye_development2.44521209
16MP0002269_muscular_atrophy2.40874574
17MP0002092_abnormal_eye_morphology2.30257088
18MP0002972_abnormal_cardiac_muscle2.25507605
19MP0003137_abnormal_impulse_conducting2.18460963
20MP0004272_abnormal_basement_membrane1.99578780
21MP0010368_abnormal_lymphatic_system1.99577910
22MP0005385_cardiovascular_system_phenoty1.92219399
23MP0001544_abnormal_cardiovascular_syste1.92219399
24MP0008775_abnormal_heart_ventricle1.91745320
25MP0010630_abnormal_cardiac_muscle1.90356907
26MP0006138_congestive_heart_failure1.85913051
27MP0005391_vision/eye_phenotype1.79848412
28MP0005620_abnormal_muscle_contractility1.78868101
29MP0001661_extended_life_span1.73039622
30MP0000750_abnormal_muscle_regeneration1.72806903
31MP0005369_muscle_phenotype1.67466371
32MP0002108_abnormal_muscle_morphology1.65294923
33MP0002106_abnormal_muscle_physiology1.64731829
34MP0010234_abnormal_vibrissa_follicle1.63095904
35MP0005409_darkened_coat_color1.58261647
36MP0000759_abnormal_skeletal_muscle1.51674276
37MP0002090_abnormal_vision1.50378143
38MP0003705_abnormal_hypodermis_morpholog1.49716182
39MP0003828_pulmonary_edema1.46322149
40MP0004085_abnormal_heartbeat1.45579999
41MP0000372_irregular_coat_pigmentation1.42878060
42MP0000747_muscle_weakness1.42661014
43MP0004484_altered_response_of1.40606582
44MP0005623_abnormal_meninges_morphology1.40481395
45MP0003136_yellow_coat_color1.37038388
46MP0005171_absent_coat_pigmentation1.36878328
47MP0003566_abnormal_cell_adhesion1.35342272
48MP0004130_abnormal_muscle_cell1.33636466
49MP0004233_abnormal_muscle_weight1.33101497
50MP0005248_abnormal_Harderian_gland1.26166405
51MP0003567_abnormal_fetal_cardiomyocyte1.12617892
52MP0004145_abnormal_muscle_electrophysio1.10890661
53MP0005257_abnormal_intraocular_pressure1.10640706
54MP0003221_abnormal_cardiomyocyte_apopto1.10584055
55MP0001346_abnormal_lacrimal_gland1.09855781
56MP0004510_myositis1.07061254
57MP0002127_abnormal_cardiovascular_syste1.02254297
58MP0003279_aneurysm1.01073276
59MP0000266_abnormal_heart_morphology1.00665489
60MP0000579_abnormal_nail_morphology1.00419417
61MP0001299_abnormal_eye_distance/0.97624325
62MP0003950_abnormal_plasma_membrane0.90057136
63MP0008438_abnormal_cutaneous_collagen0.89883589
64MP0000462_abnormal_digestive_system0.88857867
65MP0010352_gastrointestinal_tract_polyps0.88599486
66MP0003937_abnormal_limbs/digits/tail_de0.88263201
67MP0005187_abnormal_penis_morphology0.86491317
68MP0000015_abnormal_ear_pigmentation0.84674556
69MP0002128_abnormal_blood_circulation0.82857366
70MP0001879_abnormal_lymphatic_vessel0.80923230
71MP0001730_embryonic_growth_arrest0.79229802
72MP0000013_abnormal_adipose_tissue0.77733931
73MP0005666_abnormal_adipose_tissue0.77401746
74MP0003045_fibrosis0.76618057
75MP0000371_diluted_coat_color0.73678913
76MP0002102_abnormal_ear_morphology0.72740484
77MP0005408_hypopigmentation0.72323273
78MP0000762_abnormal_tongue_morphology0.70269565
79MP0002925_abnormal_cardiovascular_devel0.69928260
80MP0004185_abnormal_adipocyte_glucose0.69625727
81MP0002009_preneoplasia0.68639394
82MP0005319_abnormal_enzyme/_coenzyme0.68054310
83MP0002234_abnormal_pharynx_morphology0.67558355
84MP0000767_abnormal_smooth_muscle0.67518525
85MP0005275_abnormal_skin_tensile0.65572584
86MP0008961_abnormal_basal_metabolism0.65153957
87MP0002075_abnormal_coat/hair_pigmentati0.63442511
88MP0002332_abnormal_exercise_endurance0.62231035
89MP0001784_abnormal_fluid_regulation0.58369382
90MP0001614_abnormal_blood_vessel0.57552798
91MP0002295_abnormal_pulmonary_circulatio0.57203169
92MP0000733_abnormal_muscle_development0.56840607
93MP0001958_emphysema0.55897069
94MP0000230_abnormal_systemic_arterial0.54494142
95MP0004134_abnormal_chest_morphology0.52493784
96MP0001697_abnormal_embryo_size0.52423484
97MP0008057_abnormal_DNA_replication0.51989633
98MP0003453_abnormal_keratinocyte_physiol0.51958677
99MP0010678_abnormal_skin_adnexa0.51913295
100MP0001186_pigmentation_phenotype0.51675973
101MP0005195_abnormal_posterior_eye0.51286036
102MP0002086_abnormal_extraembryonic_tissu0.51048207
103MP0005165_increased_susceptibility_to0.49971008
104MP0002877_abnormal_melanocyte_morpholog0.49706680
105MP0003984_embryonic_growth_retardation0.49014121
106MP0005670_abnormal_white_adipose0.47803078
107MP0009384_cardiac_valve_regurgitation0.47723724
108MP0001340_abnormal_eyelid_morphology0.47370914
109MP0000343_altered_response_to0.47304916
110MP0002088_abnormal_embryonic_growth/wei0.47089832
111MP0005451_abnormal_body_composition0.46764742
112MP0005375_adipose_tissue_phenotype0.46615458
113MP0003115_abnormal_respiratory_system0.42671233
114MP0009250_abnormal_appendicular_skeleto0.42608596
115MP0000049_abnormal_middle_ear0.42373645
116MP0000428_abnormal_craniofacial_morphol0.42340529
117MP0002638_abnormal_pupillary_reflex0.40863248
118MP0009780_abnormal_chondrocyte_physiolo0.40271250
119MP0003123_paternal_imprinting0.39673865
120MP0002735_abnormal_chemical_nociception0.39322948
121MP0006036_abnormal_mitochondrial_physio0.37847469
122MP0009053_abnormal_anal_canal0.37250454
123MP0005380_embryogenesis_phenotype0.35318023
124MP0001672_abnormal_embryogenesis/_devel0.35318023
125MP0003935_abnormal_craniofacial_develop0.33695577
126MP0002089_abnormal_postnatal_growth/wei0.32636836
127MP0003385_abnormal_body_wall0.31353035
128MP0004197_abnormal_fetal_growth/weight/0.29577146
129MP0003091_abnormal_cell_migration0.28945309
130MP0005595_abnormal_vascular_smooth0.28881609
131MP0000537_abnormal_urethra_morphology0.26826718

Predicted human phenotypes

RankGene SetZ-score
1Congenital cataract (HP:0000519)7.57279731
2Corneal dystrophy (HP:0001131)6.59483996
3Amblyopia (HP:0000646)6.24229334
4Anterior segment dysgenesis (HP:0007700)5.55305239
5Polar cataract (HP:0010696)4.19524308
6Double outlet right ventricle (HP:0001719)3.60181839
7Congenital malformation of the right heart (HP:0011723)3.60181839
8Hypoplastic left heart (HP:0004383)3.53880986
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.43635868
10Sudden death (HP:0001699)3.38704441
11Clumsiness (HP:0002312)3.24332641
12Microcornea (HP:0000482)3.24146836
13Bradycardia (HP:0001662)3.02980732
14Nuclear cataract (HP:0100018)25.5323898
15* Zonular cataract (HP:0010920)21.1276209
16Ragged-red muscle fibers (HP:0003200)2.97130034
17Muscle fiber splitting (HP:0003555)2.80488818
18Hip contracture (HP:0003273)2.80203679
19Scapular winging (HP:0003691)2.77497211
20Patent foramen ovale (HP:0001655)2.72366539
21Ventricular tachycardia (HP:0004756)2.69155372
22Atrial fibrillation (HP:0005110)2.53986559
23Abnormality of the anterior chamber (HP:0000593)2.49710059
24Bicuspid aortic valve (HP:0001647)2.43689238
25Proximal amyotrophy (HP:0007126)2.43587307
26Iris coloboma (HP:0000612)2.43425222
27Abnormal ventriculo-arterial connection (HP:0011563)2.37172672
28Transposition of the great arteries (HP:0001669)2.37172672
29Abnormal connection of the cardiac segments (HP:0011545)2.37172672
30Primary atrial arrhythmia (HP:0001692)2.36367059
31Eosinophilia (HP:0001880)2.34030617
32Limited hip movement (HP:0008800)2.33876402
33Aplasia cutis congenita (HP:0001057)2.30079681
34Supraventricular arrhythmia (HP:0005115)2.29118748
35Supraventricular tachycardia (HP:0004755)2.27539123
36Hyporeflexia of lower limbs (HP:0002600)2.27036554
37Right ventricular cardiomyopathy (HP:0011663)2.26835772
38Opacification of the corneal stroma (HP:0007759)2.25967182
39Exercise-induced muscle cramps (HP:0003710)2.22808702
40Syncope (HP:0001279)2.21839605
41Calf muscle hypertrophy (HP:0008981)2.18086249
42Lipoatrophy (HP:0100578)2.14468316
43Abnormality of the left ventricular outflow tract (HP:0011103)2.13794593
44Subaortic stenosis (HP:0001682)2.13794593
45EMG: neuropathic changes (HP:0003445)2.11459184
46Resting tremor (HP:0002322)2.11360858
47Progressive muscle weakness (HP:0003323)2.09004629
48Exercise-induced myalgia (HP:0003738)2.08693452
49Pulmonary artery stenosis (HP:0004415)2.08585852
50Abnormality of the calf musculature (HP:0001430)2.02536393
51Diaphragmatic weakness (HP:0009113)2.02101764
52Muscular dystrophy (HP:0003560)1.99222914
53Preauricular pit (HP:0004467)1.98155441
54Periauricular skin pits (HP:0100277)1.98155441
55Rimmed vacuoles (HP:0003805)1.97496276
56Ventricular arrhythmia (HP:0004308)1.96475456
57Prolonged QT interval (HP:0001657)1.96296740
58Sclerocornea (HP:0000647)1.95884902
59Skin pits (HP:0100276)1.94669131
60Abnormality of the tricuspid valve (HP:0001702)1.93165234
61Muscle hypertrophy of the lower extremities (HP:0008968)1.90698970
62White forelock (HP:0002211)1.89670198
63Knee flexion contracture (HP:0006380)1.89642772
64Bundle branch block (HP:0011710)1.88069177
65Type 1 muscle fiber predominance (HP:0003803)1.85523746
66Mitral regurgitation (HP:0001653)1.85401481
67Ventricular fibrillation (HP:0001663)1.83061870
68Abnormality of glycolysis (HP:0004366)1.80760153
69Mildly elevated creatine phosphokinase (HP:0008180)1.80466563
70Granulocytopenia (HP:0001913)1.76010485
71Coarctation of aorta (HP:0001680)1.73910315
72Congestive heart failure (HP:0001635)1.73502485
73Patchy hypopigmentation of hair (HP:0011365)1.73306559
74Palpitations (HP:0001962)1.72988291
75Elbow flexion contracture (HP:0002987)1.72205517
76Dilated cardiomyopathy (HP:0001644)1.71630587
77Asymmetric septal hypertrophy (HP:0001670)1.71506533
78Toxemia of pregnancy (HP:0100603)1.71095102
79Myoglobinuria (HP:0002913)1.70465999
80Atrioventricular block (HP:0001678)1.70312407
81Abnormality of the shoulder girdle musculature (HP:0001435)1.70161832
82Generalized muscle weakness (HP:0003324)1.68137962
83Blue irides (HP:0000635)1.68092678
84EMG: myopathic abnormalities (HP:0003458)1.67877502
85Aplasia of the musculature (HP:0100854)1.67013680
86Neonatal respiratory distress (HP:0002643)1.65350314
87Metatarsus adductus (HP:0001840)1.62718408
88Posterior subcapsular cataract (HP:0007787)1.61313851
89Increased connective tissue (HP:0009025)1.61243746
90Mitral valve prolapse (HP:0001634)1.60589246
91Aneurysm (HP:0002617)1.60029708
92Abnormality of the fetal cardiovascular system (HP:0010948)1.59506768
93Abnormal umbilical cord blood vessels (HP:0011403)1.59506768
94Single umbilical artery (HP:0001195)1.59506768
95Disproportionate tall stature (HP:0001519)1.57501636
96Progressive external ophthalmoplegia (HP:0000590)1.55697657
97Heart block (HP:0012722)1.51936474
98Arterial tortuosity (HP:0005116)1.51691232
99Spinal rigidity (HP:0003306)1.51646626
100Increased serum pyruvate (HP:0003542)1.51455982
101Skin nodule (HP:0200036)1.51334671
102Truncus arteriosus (HP:0001660)1.49601303
103Aplasia/Hypoplasia of the lens (HP:0008063)1.48320070
104Abnormal atrioventricular conduction (HP:0005150)1.47110481
105Lymphangioma (HP:0100764)1.46862084
106Congenital primary aphakia (HP:0007707)1.46632612
107Late onset (HP:0003584)1.45970330
108Osteolytic defects of the hand bones (HP:0009699)1.44833622
109Osteolytic defects of the phalanges of the hand (HP:0009771)1.44833622
110Abnormality of eosinophils (HP:0001879)1.44138323
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.44078226
112Hypoplasia of the fovea (HP:0007750)1.44078226
113Premature rupture of membranes (HP:0001788)1.43863246
114Atrophic scars (HP:0001075)1.42217566
115Difficulty walking (HP:0002355)1.37908339
116Steppage gait (HP:0003376)1.37833869
117Vascular tortuosity (HP:0004948)1.37076324
118Abnormality of chromosome segregation (HP:0002916)1.37009817
119Long clavicles (HP:0000890)1.36555309
120Difficulty climbing stairs (HP:0003551)1.36225621
121Hypoplastic heart (HP:0001961)1.35698994
122Popliteal pterygium (HP:0009756)1.35011513
123Fetal akinesia sequence (HP:0001989)1.34443676
124Abnormal EKG (HP:0003115)1.33321859
125Aplasia/Hypoplasia of the macula (HP:0008059)1.31329703
126Aplasia/Hypoplasia affecting the retina (HP:0008061)1.30780881
127Exostoses (HP:0100777)1.29551876
128Rhabdomyolysis (HP:0003201)1.18795137
129Myotonia (HP:0002486)1.17556940
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.17183711
131Difficulty running (HP:0009046)1.17031840
132Abnormality of placental membranes (HP:0011409)1.12770931
133Amniotic constriction ring (HP:0009775)1.12770931
134Hamartoma of the eye (HP:0010568)1.08125817
135Palmoplantar keratoderma (HP:0000982)1.03217367
136Thin ribs (HP:0000883)1.02476296
137Hypoplastic nipples (HP:0002557)1.02199672
138Limb-girdle muscle atrophy (HP:0003797)1.01188334
139Fused cervical vertebrae (HP:0002949)1.00945299
140Abnormality of the foot musculature (HP:0001436)1.00069094
141Aplasia/Hypoplasia involving the musculature (HP:0001460)0.99968574
142Pterygium (HP:0001059)0.99097284
143Sudden cardiac death (HP:0001645)0.95688407
144Left ventricular hypertrophy (HP:0001712)0.95029738
145Neck muscle weakness (HP:0000467)0.94925504
146Vertebral clefting (HP:0008428)0.93443479
147Foot dorsiflexor weakness (HP:0009027)0.93199574
148Increased variability in muscle fiber diameter (HP:0003557)0.90180154
149Hypoplastic ischia (HP:0003175)0.89805560
150Distal lower limb muscle weakness (HP:0009053)0.89590437
151Ketoacidosis (HP:0001993)0.88963922
152Rib fusion (HP:0000902)0.88752057
153Subcapsular cataract (HP:0000523)0.88304575
154Leukocytosis (HP:0001974)0.87743499
155Visceral angiomatosis (HP:0100761)0.87391826
156Cystic hygroma (HP:0000476)0.86889533
157Camptodactyly of toe (HP:0001836)0.86489278
158Mesangial abnormality (HP:0001966)0.85600247
159Rapidly progressive (HP:0003678)0.85014672
160Broad metatarsal (HP:0001783)0.84977884
161Limb-girdle muscle weakness (HP:0003325)0.84306103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K64.48841642
2TTN4.34310147
3PKN23.95812226
4TRIB33.66991592
5MYLK3.02248770
6PHKG12.94003290
7PHKG22.94003290
8LMTK22.87176879
9DMPK2.74610316
10WNK42.67137423
11SGK12.49954763
12FLT32.05670812
13STK392.00567206
14PAK31.89139252
15PDGFRA1.84308619
16BLK1.80813411
17PDK31.78448776
18PDK41.78448776
19NEK11.68630886
20MST1R1.61360327
21EPHB21.60559872
22LATS11.60027110
23DDR21.56054572
24ILK1.54738386
25PRKG11.53655830
26SIK11.51286080
27OBSCN1.49019578
28LATS21.45641756
29TIE11.43957003
30STK241.38911128
31PIK3CA1.37858980
32EPHA21.36993144
33ROCK11.36690434
34BRD41.27918891
35LRRK21.23046084
36NTRK11.16936269
37STK38L1.16058301
38MUSK1.15178610
39MET1.14180585
40SCYL21.13812742
41STK31.10058943
42PRKD11.07287510
43WNK11.03904069
44PRKACB1.03099954
45BCKDK1.03050740
46LIMK11.02720164
47ROCK21.02158273
48IRAK30.99067944
49PTK60.98561580
50ICK0.95645578
51CAMK40.93507157
52IGF1R0.93488770
53BUB10.93467732
54PKN10.92133796
55EEF2K0.91338240
56RIPK10.87940328
57MST40.87693537
58MAP3K100.87568676
59MAP3K120.86892021
60CDC42BPA0.85835680
61PRKCB0.84899347
62CAMK10.84060388
63PNCK0.83692942
64PAK40.83206341
65MAP3K50.82428839
66MAPK100.78289992
67CAMK2D0.77115195
68TRPM70.76041864
69NME20.75582375
70PDK20.75079671
71PTK2B0.73994682
72PAK60.71955754
73INSR0.69277153
74PRKD30.68742072
75WEE10.68575491
76MAP3K90.66537389
77PRKACG0.66257799
78PINK10.66205772
79FER0.65887827
80RPS6KA30.65650150
81PRKAA10.65532853
82STK380.64634771
83PTK20.64026800
84ARAF0.61077353
85PIM20.60401457
86NEK20.59357472
87CDK120.56934390
88MAPK120.55541738
89STK100.55344411
90PBK0.54429405
91PAK20.53799820
92RPS6KC10.52642330
93RPS6KL10.52642330
94MAP3K70.50914328
95STK40.50816801
96DAPK30.50651699
97MAPKAPK30.49610452
98ERBB20.48214683
99GRK70.47222183
100KDR0.46837387
101NEK90.46804501
102ERBB40.46052279
103RET0.46003418
104PRKCE0.43952726
105MELK0.42190401
106EIF2AK10.41657229
107PRKCQ0.40817811
108PDGFRB0.39592724
109RPS6KA60.37415975
110MAP3K80.37411208
111RAF10.36896765
112EPHB10.36443134
113FGFR10.35699861
114RPS6KA20.35538996
115TNIK0.35237797
116AKT20.35209267
117TAOK10.34963111
118MTOR0.34779138
119TTK0.34393768
120CAMK2A0.34123293
121MAP3K30.33389678
122PLK40.33238243
123AKT30.33203731
124PRKCH0.33142712
125PRKACA0.32875222
126RPS6KA10.32168504
127TESK10.31787954
128CDK60.31530181
129CAMK1G0.29162210
130PRKAA20.29025471
131PDPK10.28211717
132ZAP700.27794205
133PRKD20.25925705
134MOS0.25679560
135ADRBK10.25142172
136UHMK10.24809168
137MAPKAPK20.24371289
138CAMKK10.23585799

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.48028984
2Dilated cardiomyopathy_Homo sapiens_hsa054143.93383148
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.85154674
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.52718106
5Cardiac muscle contraction_Homo sapiens_hsa042603.51072892
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11742577
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.89001872
8Fatty acid degradation_Homo sapiens_hsa000712.42789005
9Propanoate metabolism_Homo sapiens_hsa006402.12655474
10Carbon metabolism_Homo sapiens_hsa012001.94675465
11ECM-receptor interaction_Homo sapiens_hsa045121.92477595
12Parkinsons disease_Homo sapiens_hsa050121.83785337
13Viral myocarditis_Homo sapiens_hsa054161.82155252
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78473009
15Fatty acid metabolism_Homo sapiens_hsa012121.73456487
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61805230
17Oxidative phosphorylation_Homo sapiens_hsa001901.60793591
18Small cell lung cancer_Homo sapiens_hsa052221.58623888
19Focal adhesion_Homo sapiens_hsa045101.58440038
20Adherens junction_Homo sapiens_hsa045201.50678503
21Alzheimers disease_Homo sapiens_hsa050101.43051690
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27596813
23Amoebiasis_Homo sapiens_hsa051461.25659795
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23984167
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19979182
26Glucagon signaling pathway_Homo sapiens_hsa049221.19732679
27TGF-beta signaling pathway_Homo sapiens_hsa043501.18130326
28Biosynthesis of amino acids_Homo sapiens_hsa012301.15840317
29Pyruvate metabolism_Homo sapiens_hsa006201.15628283
30Proteoglycans in cancer_Homo sapiens_hsa052051.14246959
31Insulin resistance_Homo sapiens_hsa049311.11650408
32Insulin signaling pathway_Homo sapiens_hsa049101.11420181
33Huntingtons disease_Homo sapiens_hsa050161.10891401
34Tight junction_Homo sapiens_hsa045301.09522089
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.08298407
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08002558
37Butanoate metabolism_Homo sapiens_hsa006501.07791985
38Endometrial cancer_Homo sapiens_hsa052131.05692483
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03317418
40Lysine degradation_Homo sapiens_hsa003101.01048519
41Adipocytokine signaling pathway_Homo sapiens_hsa049200.99666754
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99236593
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94528197
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94420622
45Arginine biosynthesis_Homo sapiens_hsa002200.89924871
46Renal cell carcinoma_Homo sapiens_hsa052110.88586152
47Folate biosynthesis_Homo sapiens_hsa007900.85761182
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85215112
49mTOR signaling pathway_Homo sapiens_hsa041500.84208756
50PPAR signaling pathway_Homo sapiens_hsa033200.83678019
51Thyroid cancer_Homo sapiens_hsa052160.82100365
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81563917
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79841454
54HIF-1 signaling pathway_Homo sapiens_hsa040660.79816112
55Melanoma_Homo sapiens_hsa052180.79700338
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79312038
57AMPK signaling pathway_Homo sapiens_hsa041520.78556052
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74767964
59Protein digestion and absorption_Homo sapiens_hsa049740.74452177
60Basal cell carcinoma_Homo sapiens_hsa052170.73751614
61Fatty acid elongation_Homo sapiens_hsa000620.73456562
62Hedgehog signaling pathway_Homo sapiens_hsa043400.71614433
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71450817
64Sphingolipid metabolism_Homo sapiens_hsa006000.71313446
65Arginine and proline metabolism_Homo sapiens_hsa003300.71283782
66Oxytocin signaling pathway_Homo sapiens_hsa049210.70952593
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70640439
68Melanogenesis_Homo sapiens_hsa049160.70460922
69Type II diabetes mellitus_Homo sapiens_hsa049300.68364173
70Dorso-ventral axis formation_Homo sapiens_hsa043200.68083891
71Starch and sucrose metabolism_Homo sapiens_hsa005000.67910912
72Sulfur metabolism_Homo sapiens_hsa009200.66748902
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.64410195
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62422044
75N-Glycan biosynthesis_Homo sapiens_hsa005100.61464999
76Hippo signaling pathway_Homo sapiens_hsa043900.60454842
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60316949
78MicroRNAs in cancer_Homo sapiens_hsa052060.60029420
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59030507
80Tryptophan metabolism_Homo sapiens_hsa003800.58436630
81Pancreatic cancer_Homo sapiens_hsa052120.57024800
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56784669
83Prion diseases_Homo sapiens_hsa050200.56360308
84Pentose phosphate pathway_Homo sapiens_hsa000300.55159686
85Pancreatic secretion_Homo sapiens_hsa049720.54979443
86Cell cycle_Homo sapiens_hsa041100.53776619
87Pathways in cancer_Homo sapiens_hsa052000.52049446
88Axon guidance_Homo sapiens_hsa043600.51638048
89p53 signaling pathway_Homo sapiens_hsa041150.51225304
90Circadian entrainment_Homo sapiens_hsa047130.49842891
91Gastric acid secretion_Homo sapiens_hsa049710.49712669
92Gap junction_Homo sapiens_hsa045400.48401510
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47638595
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.43822316
95cAMP signaling pathway_Homo sapiens_hsa040240.43651571
96Estrogen signaling pathway_Homo sapiens_hsa049150.43520266
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43057982
98Prostate cancer_Homo sapiens_hsa052150.43020530
99Insulin secretion_Homo sapiens_hsa049110.42904026
100Calcium signaling pathway_Homo sapiens_hsa040200.42098595
101VEGF signaling pathway_Homo sapiens_hsa043700.42064059
102Galactose metabolism_Homo sapiens_hsa000520.41587788
103Rap1 signaling pathway_Homo sapiens_hsa040150.41479237
104Toxoplasmosis_Homo sapiens_hsa051450.41192619
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41051581
106Mineral absorption_Homo sapiens_hsa049780.40818567
107Sulfur relay system_Homo sapiens_hsa041220.40325601
108beta-Alanine metabolism_Homo sapiens_hsa004100.40230825
109Glioma_Homo sapiens_hsa052140.39798038
110Wnt signaling pathway_Homo sapiens_hsa043100.39759320
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.39615674
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39307304
113Oocyte meiosis_Homo sapiens_hsa041140.38660672
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38511433
115Renin secretion_Homo sapiens_hsa049240.37255608
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35744803
117Chronic myeloid leukemia_Homo sapiens_hsa052200.35366310
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.34966342
119mRNA surveillance pathway_Homo sapiens_hsa030150.34170457
120Bladder cancer_Homo sapiens_hsa052190.33357401
121Notch signaling pathway_Homo sapiens_hsa043300.31990853
122Thyroid hormone synthesis_Homo sapiens_hsa049180.31389638
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29720089
124Non-small cell lung cancer_Homo sapiens_hsa052230.29638201
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29561492
126GnRH signaling pathway_Homo sapiens_hsa049120.28197431
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25568381
128Circadian rhythm_Homo sapiens_hsa047100.25568379
129Fatty acid biosynthesis_Homo sapiens_hsa000610.24916391
130One carbon pool by folate_Homo sapiens_hsa006700.24621383
131Vibrio cholerae infection_Homo sapiens_hsa051100.23913214

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