GJA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.13165401
2negative regulation of blood vessel endothelial cell migration (GO:0043537)6.53587636
3regulation of acrosome reaction (GO:0060046)6.39848300
4regulation of vasculogenesis (GO:2001212)5.85827229
5heart trabecula morphogenesis (GO:0061384)5.71659405
6vascular endothelial growth factor signaling pathway (GO:0038084)5.61723005
7positive regulation of vasculogenesis (GO:2001214)5.49327688
8regulation of endothelial cell differentiation (GO:0045601)5.48015854
9regulation of phospholipid biosynthetic process (GO:0071071)5.47084154
10lymph vessel development (GO:0001945)5.45260110
11base-excision repair, AP site formation (GO:0006285)5.40920431
12sprouting angiogenesis (GO:0002040)5.35413184
13protein kinase C signaling (GO:0070528)5.34775186
14* endothelium development (GO:0003158)5.32981931
15notochord development (GO:0030903)5.15079014
16angiogenesis involved in wound healing (GO:0060055)5.13582241
17trabecula morphogenesis (GO:0061383)5.13346671
18negative regulation of smooth muscle cell differentiation (GO:0051151)5.12533457
19regulation of hypersensitivity (GO:0002883)5.09142859
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.04317373
21multicellular organism reproduction (GO:0032504)4.85250936
22negative regulation of endothelial cell migration (GO:0010596)4.84911500
23positive regulation of endothelial cell differentiation (GO:0045603)4.84238276
24cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.83186927
25oocyte development (GO:0048599)4.80045789
26positive regulation of calcium ion import (GO:0090280)4.75793251
27peptidyl-tyrosine autophosphorylation (GO:0038083)4.70863914
28surfactant homeostasis (GO:0043129)4.65999580
29cell migration involved in sprouting angiogenesis (GO:0002042)4.61284389
30morphogenesis of an endothelium (GO:0003159)4.60631628
31endothelial tube morphogenesis (GO:0061154)4.60631628
32pyrimidine nucleotide catabolic process (GO:0006244)4.46847696
33positive regulation of Cdc42 GTPase activity (GO:0043089)4.43578861
34blood vessel endothelial cell migration (GO:0043534)4.30630250
35positive regulation of humoral immune response (GO:0002922)4.23583727
36retina vasculature morphogenesis in camera-type eye (GO:0061299)4.19397124
37female gamete generation (GO:0007292)4.14696445
38protein localization to kinetochore (GO:0034501)4.08972403
39regulation of meiosis (GO:0040020)4.07553532
40embryonic heart tube development (GO:0035050)4.07091997
41regulation of blood vessel endothelial cell migration (GO:0043535)4.07008564
42lymphangiogenesis (GO:0001946)4.04604695
43reproduction (GO:0000003)3.98421181
44atrioventricular valve morphogenesis (GO:0003181)3.95889574
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.94231135
46endothelial cell differentiation (GO:0045446)3.94020318
47blood vessel maturation (GO:0001955)3.92835641
48DNA methylation involved in gamete generation (GO:0043046)3.92438215
49gap junction assembly (GO:0016264)3.91640500
50basement membrane organization (GO:0071711)3.90388429
51Notch receptor processing (GO:0007220)3.88521929
52mRNA transcription from RNA polymerase II promoter (GO:0042789)3.87888536
53patterning of blood vessels (GO:0001569)3.80350347
54heart trabecula formation (GO:0060347)3.79437244
55ventricular cardiac muscle cell development (GO:0055015)3.78058976
56negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.77823361
57endocardial cushion morphogenesis (GO:0003203)3.75731773
58chemical homeostasis within a tissue (GO:0048875)3.70516362
59positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.68799234
60negative regulation of epithelial cell migration (GO:0010633)3.65207064
61negative regulation of reproductive process (GO:2000242)3.65099293
62mitotic chromosome condensation (GO:0007076)3.65029013
63regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.64931951
64cGMP-mediated signaling (GO:0019934)3.64653757
65cardiac epithelial to mesenchymal transition (GO:0060317)3.64091469
66glomerular filtration (GO:0003094)3.56833704
67regulation of calcium ion import (GO:0090279)3.55540900
68citrulline biosynthetic process (GO:0019240)3.54076697
69positive regulation of protein kinase C signaling (GO:0090037)3.51887797
70immunoglobulin mediated immune response (GO:0016064)3.50807723
71vasculogenesis (GO:0001570)3.49340190
72negative regulation of meiotic cell cycle (GO:0051447)3.47250473
73endothelial cell morphogenesis (GO:0001886)3.47062915
74muscle cell migration (GO:0014812)3.46117463
75negative regulation of vascular permeability (GO:0043116)3.44437508
76cell surface receptor signaling pathway involved in heart development (GO:0061311)3.43774808
77blood vessel morphogenesis (GO:0048514)3.43718289
78Notch signaling involved in heart development (GO:0061314)3.42834558
79wound healing, spreading of epidermal cells (GO:0035313)3.42392815
80negative regulation of angiogenesis (GO:0016525)3.41692313
81regulation of endothelial cell migration (GO:0010594)3.41529736
82renal filtration (GO:0097205)3.40425707
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.37790511
84regulation of smooth muscle cell differentiation (GO:0051150)3.35548173
85nephron epithelium development (GO:0072009)3.31341790
86regulation of cardioblast differentiation (GO:0051890)3.30802933
87mRNA transcription (GO:0009299)3.29331872
88positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.29113968
89negative regulation of blood vessel morphogenesis (GO:2000181)3.27655458
90angiogenesis (GO:0001525)3.23545215
91regulation of meiotic cell cycle (GO:0051445)3.23535094
92mitotic metaphase plate congression (GO:0007080)3.18901189
93endothelial cell chemotaxis (GO:0035767)3.17303822
94substrate-dependent cell migration (GO:0006929)3.16911972
95protein localization to chromosome, centromeric region (GO:0071459)3.16756314
96negative regulation of vasculature development (GO:1901343)3.16403777
97positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.13711089
98positive regulation of odontogenesis (GO:0042482)3.12168060
99aorta morphogenesis (GO:0035909)3.12086052
100negative regulation of meiosis (GO:0045835)3.11720788
101cell migration involved in heart development (GO:0060973)3.11201403
102positive regulation of urine volume (GO:0035810)3.11077926
103oocyte maturation (GO:0001556)3.10868827
104atrial cardiac muscle cell action potential (GO:0086014)3.08195882
105ventricular trabecula myocardium morphogenesis (GO:0003222)3.06738184
106negative regulation of focal adhesion assembly (GO:0051895)3.04346780
107negative regulation of cell junction assembly (GO:1901889)3.04346780
108negative regulation of adherens junction organization (GO:1903392)3.04346780
109vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.02798547
110fibrinolysis (GO:0042730)3.01368854
111artery development (GO:0060840)2.99779324
112glomerulus development (GO:0032835)2.98714077
113histone H2A ubiquitination (GO:0033522)2.97267520
114regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.96207935
115negative regulation of platelet activation (GO:0010544)2.95463993
116blood vessel remodeling (GO:0001974)2.92128010
117wound healing, spreading of cells (GO:0044319)2.91797691
118regulation of Cdc42 GTPase activity (GO:0043088)2.91693386
119microtubule severing (GO:0051013)2.89857230
120endothelial cell migration (GO:0043542)2.88305982
121negative regulation of blood coagulation (GO:0030195)2.87199860
122negative regulation of hemostasis (GO:1900047)2.87199860
123platelet-derived growth factor receptor signaling pathway (GO:0048008)2.86890097
124positive regulation of endothelial cell migration (GO:0010595)2.86021849
125artery morphogenesis (GO:0048844)2.85900013
126relaxation of smooth muscle (GO:0044557)2.82571578
127bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82446869
128heart valve formation (GO:0003188)2.81875059
129endothelial cell proliferation (GO:0001935)2.81527438
130ovulation from ovarian follicle (GO:0001542)2.81491140
131attachment of spindle microtubules to kinetochore (GO:0008608)2.80394185
132cAMP biosynthetic process (GO:0006171)2.80099838
133calcium-mediated signaling using intracellular calcium source (GO:0035584)2.76485056
134negative regulation of endothelial cell apoptotic process (GO:2000352)2.75191603
135regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.73397513
136gene silencing by RNA (GO:0031047)2.72941990
137regulation of sister chromatid cohesion (GO:0007063)2.72818169
138coronary vasculature morphogenesis (GO:0060977)2.71661005
139mesenchyme morphogenesis (GO:0072132)2.70744622
140establishment of endothelial barrier (GO:0061028)2.69991476
141positive regulation of reproductive process (GO:2000243)2.69258700
142cardiac muscle cell development (GO:0055013)2.69226376
143regulation of transforming growth factor beta2 production (GO:0032909)2.68703122
144negative regulation of coagulation (GO:0050819)2.68695341
145regulation of steroid hormone biosynthetic process (GO:0090030)2.68453095
146cardiac myofibril assembly (GO:0055003)2.68448142
147labyrinthine layer development (GO:0060711)2.68085944
148regulation of epithelial cell migration (GO:0010632)2.67801412
149outflow tract morphogenesis (GO:0003151)2.67710841
150positive regulation of lipid kinase activity (GO:0090218)2.66511858
151transcytosis (GO:0045056)2.66177169
152ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.66076008
153positive regulation of focal adhesion assembly (GO:0051894)2.65613684
154positive regulation of cell junction assembly (GO:1901890)2.65613684
155cardiac ventricle morphogenesis (GO:0003208)2.64486508
156hyaluronan catabolic process (GO:0030214)2.63144599
157positive regulation of adherens junction organization (GO:1903393)2.62717953
158positive regulation of endothelial cell proliferation (GO:0001938)2.61294522
159Rap protein signal transduction (GO:0032486)2.59718648
160regulation of angiogenesis (GO:0045765)2.56080024
161positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.53522601
162regulation of vasculature development (GO:1901342)2.51918070
163regulation of female gonad development (GO:2000194)10.0318765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.41599826
2CLOCK_20551151_ChIP-Seq_293T_Human3.75098037
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.31040749
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.16275280
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.95009707
6GATA2_21666600_ChIP-Seq_HMVEC_Human2.74297830
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.72971225
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.67163989
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.63167355
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61269203
11AR_21909140_ChIP-Seq_LNCAP_Human2.48627765
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.37866614
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34041680
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.29547450
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.26553901
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.06900413
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.02388365
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.01883793
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.99789634
20* TBX20_22080862_ChIP-Seq_HEART_Mouse1.95738824
21* TBX20_22328084_ChIP-Seq_HEART_Mouse1.95738824
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.94267679
23SALL4_18804426_ChIP-ChIP_XEN_Mouse1.92967879
24CJUN_26792858_Chip-Seq_BT549_Human1.90427625
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87435565
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.87341852
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84260530
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84260530
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84260530
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82372189
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80963779
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.79569981
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77109096
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.69430033
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.68017878
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62809126
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61102737
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54228917
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52110902
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49830657
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48525582
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48443247
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.46947044
44EZH2_22144423_ChIP-Seq_EOC_Human1.46823576
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46412190
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43123611
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41543899
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38407145
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37909915
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36128536
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.35097885
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34623228
53LXR_22292898_ChIP-Seq_THP-1_Human1.32792540
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31444118
55KDM2B_26808549_Chip-Seq_K562_Human1.31076314
56CSB_26484114_Chip-Seq_FIBROBLAST_Human1.29486573
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.28802329
58KAP1_22055183_ChIP-Seq_ESCs_Mouse1.27374339
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26143767
60PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24632617
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23133993
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22627071
63BCAT_22108803_ChIP-Seq_LS180_Human1.21893148
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21738195
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20418570
66MYC_27129775_Chip-Seq_CORNEA_Mouse1.20307674
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19881112
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.19729420
69* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19625734
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19584980
71* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18812220
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17663885
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.17138843
74CDX2_22108803_ChIP-Seq_LS180_Human1.16793192
75DROSHA_22980978_ChIP-Seq_HELA_Human1.15830887
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14920707
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.14578036
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12000128
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.11326654
80SCL_19346495_ChIP-Seq_HPC-7_Human1.10629408
81* NFYA_21822215_ChIP-Seq_K562_Human1.10410431
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09330704
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.08391410
84TP63_23658742_ChIP-Seq_EP156T_Human1.08334535
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06983261
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06668089
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05810275
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05810275
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05486891
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.05447338
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04412930
92BRD4_25478319_ChIP-Seq_HGPS_Human1.03705086
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03260312
94TP63_22573176_ChIP-Seq_HFKS_Human1.03170027
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03025948
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02918841
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02891126
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02885301
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02689368
100SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02495314
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02102038
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01624052
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01407977
104RACK7_27058665_Chip-Seq_MCF-7_Human1.00455286
105SOX2_20726797_ChIP-Seq_SW620_Human0.99047526
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98331544
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.97567662
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97115358
109ESET_19884257_ChIP-Seq_ESCs_Mouse0.96667961
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.96242079
111* CTCF_27219007_Chip-Seq_Bcells_Human0.96156499
112KDM2B_26808549_Chip-Seq_DND41_Human0.95771543
113TP63_17297297_ChIP-ChIP_HaCaT_Human0.93892342
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93074647
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92446843
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90620594
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90456382
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89389336
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.88625342
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88602851
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.88505782
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.87472613
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86869110
124ATF3_27146783_Chip-Seq_COLON_Human0.86608736
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85500595
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85107571
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84860647
128OCT1_27270436_Chip-Seq_PROSTATE_Human0.83106702
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82293568
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81472335
131SOX11_22085726_ChIP-Seq_ESNs_Mouse0.81078173
132SA1_22415368_ChIP-Seq_MEFs_Mouse0.79887100
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.79845810
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79145559
135KLF4_19829295_ChIP-Seq_ESCs_Human0.78648900
136GATA1_19941826_ChIP-Seq_K562_Human0.78517470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.00408491
2MP0005167_abnormal_blood-brain_barrier5.28765230
3MP0001879_abnormal_lymphatic_vessel4.57987292
4MP0004272_abnormal_basement_membrane4.11946867
5MP0003718_maternal_effect4.08237139
6MP0003279_aneurysm2.73757701
7MP0003646_muscle_fatigue2.72073920
8MP0004084_abnormal_cardiac_muscle2.56093283
9MP0000767_abnormal_smooth_muscle2.49029241
10MP0005409_darkened_coat_color2.36157615
11MP0003303_peritoneal_inflammation2.23582493
12* MP0002295_abnormal_pulmonary_circulatio2.23092549
13MP0006138_congestive_heart_failure2.18680591
14MP0003705_abnormal_hypodermis_morpholog2.14924347
15MP0004215_abnormal_myocardial_fiber2.10095390
16MP0002127_abnormal_cardiovascular_syste2.05873663
17MP0006054_spinal_hemorrhage1.99792367
18MP0004036_abnormal_muscle_relaxation1.99700246
19MP0009384_cardiac_valve_regurgitation1.85709360
20MP0005165_increased_susceptibility_to1.83146756
21MP0005395_other_phenotype1.82789563
22MP0002138_abnormal_hepatobiliary_system1.75366457
23MP0002972_abnormal_cardiac_muscle1.74465783
24MP0000751_myopathy1.65581133
25* MP0003699_abnormal_female_reproductive1.64588479
26MP0005620_abnormal_muscle_contractility1.63356753
27MP0005360_urolithiasis1.62463746
28MP0004782_abnormal_surfactant_physiolog1.62130531
29MP0005451_abnormal_body_composition1.62080792
30MP0004484_altered_response_of1.60812157
31MP0008775_abnormal_heart_ventricle1.60395075
32MP0003950_abnormal_plasma_membrane1.58015646
33MP0003828_pulmonary_edema1.57648326
34MP0005670_abnormal_white_adipose1.53830367
35MP0001544_abnormal_cardiovascular_syste1.52875129
36MP0005385_cardiovascular_system_phenoty1.52875129
37MP0001915_intracranial_hemorrhage1.50370490
38* MP0001119_abnormal_female_reproductive1.50032831
39MP0002837_dystrophic_cardiac_calcinosis1.49972219
40MP0002933_joint_inflammation1.45974037
41MP0005330_cardiomyopathy1.43856167
42MP0000013_abnormal_adipose_tissue1.34922401
43* MP0000465_gastrointestinal_hemorrhage1.33405242
44* MP0002128_abnormal_blood_circulation1.32725870
45MP0005375_adipose_tissue_phenotype1.32584912
46MP0003122_maternal_imprinting1.32580808
47* MP0000249_abnormal_blood_vessel1.30758838
48MP0002332_abnormal_exercise_endurance1.30539739
49MP0000537_abnormal_urethra_morphology1.30303522
50MP0005187_abnormal_penis_morphology1.30300601
51MP0009697_abnormal_copulation1.27519011
52* MP0001614_abnormal_blood_vessel1.27452586
53MP0003724_increased_susceptibility_to1.27261092
54MP0005023_abnormal_wound_healing1.27107562
55MP0000343_altered_response_to1.25569842
56MP0004510_myositis1.23156101
57MP0000230_abnormal_systemic_arterial1.21453778
58MP0002925_abnormal_cardiovascular_devel1.19802138
59MP0009278_abnormal_bone_marrow1.19794817
60MP0004085_abnormal_heartbeat1.19504049
61MP0005275_abnormal_skin_tensile1.17223229
62MP0003121_genomic_imprinting1.16411920
63MP0010630_abnormal_cardiac_muscle1.15951713
64MP0003566_abnormal_cell_adhesion1.15208382
65* MP0005595_abnormal_vascular_smooth1.14337123
66MP0004130_abnormal_muscle_cell1.12209203
67MP0004087_abnormal_muscle_fiber1.10307784
68MP0005164_abnormal_response_to1.08168596
69MP0008877_abnormal_DNA_methylation1.05755297
70MP0003091_abnormal_cell_migration1.04815596
71MP0002932_abnormal_joint_morphology1.04465100
72MP0001849_ear_inflammation1.04272425
73MP0005503_abnormal_tendon_morphology1.03585534
74MP0002108_abnormal_muscle_morphology1.03229593
75MP0005666_abnormal_adipose_tissue1.03137497
76MP0004233_abnormal_muscle_weight1.02412280
77MP0009053_abnormal_anal_canal1.01188169
78MP0000266_abnormal_heart_morphology0.97617893
79MP0010386_abnormal_urinary_bladder0.94607839
80MP0004883_abnormal_blood_vessel0.93915937
81MP0001919_abnormal_reproductive_system0.93063149
82MP0003943_abnormal_hepatobiliary_system0.89595114
83MP0003075_altered_response_to0.88851327
84MP0002269_muscular_atrophy0.87187411
85MP0002282_abnormal_trachea_morphology0.85004285
86MP0008875_abnormal_xenobiotic_pharmacok0.82235195
87MP0002254_reproductive_system_inflammat0.82007758
88MP0005623_abnormal_meninges_morphology0.80790586
89MP0000516_abnormal_urinary_system0.80230119
90MP0005367_renal/urinary_system_phenotyp0.80230119
91MP0004185_abnormal_adipocyte_glucose0.79780640
92MP0003300_gastrointestinal_ulcer0.79082482
93MP0000759_abnormal_skeletal_muscle0.78442256
94* MP0001929_abnormal_gametogenesis0.76298703
95MP0008260_abnormal_autophagy0.75730069
96MP0005369_muscle_phenotype0.73571296
97MP0001958_emphysema0.73515299
98* MP0000653_abnormal_sex_gland0.73457106
99MP0005197_abnormal_uvea_morphology0.67266720
100MP0002249_abnormal_larynx_morphology0.66366349
101MP0000733_abnormal_muscle_development0.65883982
102MP0005084_abnormal_gallbladder_morpholo0.65481219
103MP0000579_abnormal_nail_morphology0.64751633
104MP0010030_abnormal_orbit_morphology0.64025275
105MP0001905_abnormal_dopamine_level0.63385761
106MP0008438_abnormal_cutaneous_collagen0.62997967
107MP0000749_muscle_degeneration0.62838844
108* MP0002161_abnormal_fertility/fecundity0.62778372
109MP0000003_abnormal_adipose_tissue0.62190609
110MP0002106_abnormal_muscle_physiology0.61316216
111MP0005085_abnormal_gallbladder_physiolo0.60469667
112MP0001175_abnormal_lung_morphology0.60029566
113MP0004145_abnormal_muscle_electrophysio0.59933171
114MP0000747_muscle_weakness0.59812523
115MP0003453_abnormal_keratinocyte_physiol0.59315935
116MP0002086_abnormal_extraembryonic_tissu0.59219622
117MP0003693_abnormal_embryo_hatching0.57787505
118MP0010094_abnormal_chromosome_stability0.57337177
119MP0000750_abnormal_muscle_regeneration0.57169172
120MP0005388_respiratory_system_phenotype0.55919556
121MP0002133_abnormal_respiratory_system0.55919556
122MP0001672_abnormal_embryogenesis/_devel0.53979435
123MP0005380_embryogenesis_phenotype0.53979435
124MP0001784_abnormal_fluid_regulation0.53947240
125MP0003137_abnormal_impulse_conducting0.52283980
126MP0003948_abnormal_gas_homeostasis0.51668289
127MP0002971_abnormal_brown_adipose0.51376662
128MP0003283_abnormal_digestive_organ0.50148398
129MP0005365_abnormal_bile_salt0.49573476
130MP0000467_abnormal_esophagus_morphology0.48586620
131MP0005508_abnormal_skeleton_morphology0.47482341
132MP0003984_embryonic_growth_retardation0.46094984
133MP0004885_abnormal_endolymph0.45183885
134MP0005193_abnormal_anterior_eye0.44719328
135MP0002088_abnormal_embryonic_growth/wei0.43491278
136MP0003935_abnormal_craniofacial_develop0.42885571
137MP0001851_eye_inflammation0.41987201

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.49064386
2Polycythemia (HP:0001901)5.53381200
3Premature ovarian failure (HP:0008209)5.36034886
4Cortical dysplasia (HP:0002539)4.79904996
5Hemorrhage of the eye (HP:0011885)4.37396595
6Hematochezia (HP:0002573)4.29052637
7Aortic dissection (HP:0002647)4.23426950
8Male infertility (HP:0003251)4.22723172
9Aortic aneurysm (HP:0004942)4.22169726
10Spontaneous hematomas (HP:0007420)4.06124234
11Short hallux (HP:0010109)3.96040141
12Protrusio acetabuli (HP:0003179)3.91362618
13Porencephaly (HP:0002132)3.89246858
14Hyporeflexia of lower limbs (HP:0002600)3.85813281
15Atrioventricular block (HP:0001678)3.83709242
16Infertility (HP:0000789)3.74349592
17Aplasia/Hypoplasia of the hallux (HP:0008362)3.61758920
18Hemiplegia (HP:0002301)3.58827696
19Esophageal varix (HP:0002040)3.52153358
20Hypoplasia of the iris (HP:0007676)3.48602598
21Arterial tortuosity (HP:0005116)3.43178127
22Mesangial abnormality (HP:0001966)3.42853199
23Vascular tortuosity (HP:0004948)3.35598932
24Cerebral hemorrhage (HP:0001342)3.30258621
25Difficulty running (HP:0009046)3.30184948
26Cerebral aneurysm (HP:0004944)3.24809961
27Ventricular tachycardia (HP:0004756)3.20979666
28Muscle fiber splitting (HP:0003555)3.19979651
29Heart block (HP:0012722)3.17612783
30Myotonia (HP:0002486)3.16547418
31Abnormal atrioventricular conduction (HP:0005150)3.14579525
32Right ventricular cardiomyopathy (HP:0011663)3.13320048
33Ankle contracture (HP:0006466)3.11380017
34Shawl scrotum (HP:0000049)3.07936125
35Scotoma (HP:0000575)3.01542629
36Wrist flexion contracture (HP:0001239)2.99597363
37Spinal rigidity (HP:0003306)2.99096274
38Bone cyst (HP:0012062)2.94725298
39Myocardial infarction (HP:0001658)2.92142328
40Sudden death (HP:0001699)2.90178538
41Broad metatarsal (HP:0001783)2.89818321
42Nonimmune hydrops fetalis (HP:0001790)2.88607858
43Chondrocalcinosis (HP:0000934)2.79808445
44Difficulty climbing stairs (HP:0003551)2.79397715
45Distal lower limb muscle weakness (HP:0009053)2.75744651
46Growth hormone excess (HP:0000845)2.72978542
47Aneurysm (HP:0002617)2.72404991
48Abnormality of the nasal mucosa (HP:0000433)2.63897071
49Skull defect (HP:0001362)2.63654061
50Areflexia of lower limbs (HP:0002522)2.58197107
51Pulmonary artery stenosis (HP:0004415)2.57486854
52Enlarged penis (HP:0000040)2.57462179
53Abnormality of Sharpey fibers (HP:0100685)2.56763654
54Stroke (HP:0001297)2.54562744
55Complement deficiency (HP:0004431)2.52438103
56Absent hand (HP:0004050)2.51546966
57Breast hypoplasia (HP:0003187)2.50829038
58Conjunctival telangiectasia (HP:0000524)2.49480770
59Asymmetric septal hypertrophy (HP:0001670)2.48424400
60Atelectasis (HP:0100750)2.47355324
61Bulbar palsy (HP:0001283)2.45751937
62Hyperlipoproteinemia (HP:0010980)2.45747094
63Adactyly (HP:0009776)2.38009070
64Shallow orbits (HP:0000586)2.37361484
65Round ear (HP:0100830)2.37199692
66Camptodactyly of toe (HP:0001836)2.35808289
67Nemaline bodies (HP:0003798)2.33819744
68Diastasis recti (HP:0001540)2.30588707
69Atrial fibrillation (HP:0005110)2.30123406
70Visceral angiomatosis (HP:0100761)2.30105949
71Reduced subcutaneous adipose tissue (HP:0003758)2.29748179
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.28598323
73Lymphangioma (HP:0100764)2.27658541
74Overgrowth (HP:0001548)2.27060425
75Muscle fiber inclusion bodies (HP:0100299)2.26158270
76Hemangiomatosis (HP:0007461)2.23667463
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.23027790
78Short 4th metacarpal (HP:0010044)2.23027790
79Distal arthrogryposis (HP:0005684)2.22975679
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.22837789
81Neonatal death (HP:0003811)2.22079179
82Increased variability in muscle fiber diameter (HP:0003557)2.22076013
83Systemic lupus erythematosus (HP:0002725)2.21337235
84Supraventricular arrhythmia (HP:0005115)2.21237101
85Intestinal polyp (HP:0005266)2.20929665
86Ulnar deviation of the wrist (HP:0003049)2.20409580
87Abnormality of the 4th metacarpal (HP:0010012)2.19539333
88Mitral valve prolapse (HP:0001634)2.17664591
89Long toe (HP:0010511)2.17042268
90Lipoatrophy (HP:0100578)2.14843540
91Acanthosis nigricans (HP:0000956)2.14779132
92Abnormality of alanine metabolism (HP:0010916)2.13397872
93Hyperalaninemia (HP:0003348)2.13397872
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13397872
95EMG: myopathic abnormalities (HP:0003458)2.12986899
96Intestinal polyposis (HP:0200008)2.12481837
97Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.11423434
98Short 1st metacarpal (HP:0010034)2.11423434
99Portal hypertension (HP:0001409)2.09734342
100Primary atrial arrhythmia (HP:0001692)2.08640554
101Increased connective tissue (HP:0009025)2.06582960
102Capillary hemangiomas (HP:0005306)2.03979471
103Abnormality of complement system (HP:0005339)2.03338138
104Abnormal lung lobation (HP:0002101)2.02288329
105Absent toe (HP:0010760)2.01094889
106Malnutrition (HP:0004395)1.98398176
107Skin nodule (HP:0200036)1.98346781
108Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97679917
109Limited hip movement (HP:0008800)1.97124200
110Secondary amenorrhea (HP:0000869)1.96289178
111Supraventricular tachycardia (HP:0004755)1.95822969
112Exercise-induced myalgia (HP:0003738)1.94906878
113Hyperglycemia (HP:0003074)1.94876768
114Hydroureter (HP:0000072)1.92712170
115Type 1 muscle fiber predominance (HP:0003803)1.92657031
116Premature rupture of membranes (HP:0001788)1.92260716
117Insulin-resistant diabetes mellitus (HP:0000831)1.91449604
118Hypoglycemic seizures (HP:0002173)1.90808547
119Abnormality of the ischium (HP:0003174)1.89659188
120Venous abnormality (HP:0002624)1.88707099
121Venous insufficiency (HP:0005293)1.87424845
122Hemiparesis (HP:0001269)1.86183492
123Abnormality of the hepatic vasculature (HP:0006707)1.85931405
124Short phalanx of the thumb (HP:0009660)1.85722601
125Syncope (HP:0001279)1.84654523
126Cavernous hemangioma (HP:0001048)1.84302983
127Abnormality of skeletal muscle fiber size (HP:0012084)1.84256893
128Patellar aplasia (HP:0006443)1.82656321
129Abnormality of the 1st metacarpal (HP:0010009)1.81650428
130Amyloidosis (HP:0011034)1.80720843
131Joint hemorrhage (HP:0005261)1.80714106
132Limb dystonia (HP:0002451)1.79896722
133Ectopia lentis (HP:0001083)1.79249783
134Abnormality of the calf musculature (HP:0001430)1.78033134
135Aortic valve stenosis (HP:0001650)1.77957728
136Nephroblastoma (Wilms tumor) (HP:0002667)1.77901865
137Flat capital femoral epiphysis (HP:0003370)1.77493161
138Aplasia/Hypoplasia of the patella (HP:0006498)1.77221984
139Distal lower limb amyotrophy (HP:0008944)1.77094057
140Joint contractures involving the joints of the feet (HP:0100492)1.76932207
141Flexion contracture of toe (HP:0005830)1.76932207
142Congenital, generalized hypertrichosis (HP:0004540)1.76385903
143Hip contracture (HP:0003273)1.76050740
144Pulmonary hypertension (HP:0002092)1.75975882
145Rhabdomyosarcoma (HP:0002859)1.73823596
146Preaxial foot polydactyly (HP:0001841)1.73525352
147Bundle branch block (HP:0011710)1.73002676
148Tetraparesis (HP:0002273)1.72685257
149Axonal loss (HP:0003447)1.71754616
150Neck muscle weakness (HP:0000467)1.71113459
151Focal segmental glomerulosclerosis (HP:0000097)1.71005580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.82465834
2KDR4.21213739
3MOS4.09635996
4BMPR23.79492699
5INSRR3.69753322
6MAP3K63.29766546
7MYLK3.26797003
8TTK2.96993585
9STK102.48185254
10FES2.17783197
11TGFBR22.14670931
12LATS22.01973220
13DMPK2.01144784
14PRKD31.86060923
15TAOK31.82734733
16ERN11.82561745
17GRK11.78365249
18PTK2B1.76634891
19BRAF1.69724365
20ERBB41.66749468
21EPHB21.64148918
22LATS11.60471903
23PDGFRA1.55089203
24TGFBR11.53779723
25TTN1.49318576
26STK38L1.43623086
27TSSK61.41002135
28KIT1.35879982
29KSR21.30043544
30FER1.24354599
31PLK41.19946550
32TAOK11.18801649
33MAPK151.16587192
34MAPKAPK31.06178018
35TRIB31.05764629
36NTRK11.03179754
37LRRK20.98339525
38MELK0.97382384
39CSK0.95172550
40RET0.93717352
41MAP3K80.88464668
42MAP3K130.84139864
43OBSCN0.83204332
44PKN20.82728820
45RIPK10.82629700
46EEF2K0.82061430
47PAK20.79019028
48EPHA30.78541189
49ABL20.78201250
50CDK90.78040454
51NLK0.77938844
52PRKG20.75374018
53MET0.75138294
54MAPKAPK50.73888744
55PTK60.73364955
56MAP3K110.72713754
57MAPK70.72414264
58ROCK10.71952540
59TRPM70.71835432
60PRKAA20.71034214
61PAK40.70767492
62PLK10.69170272
63MAP3K30.67754023
64CDK80.65469394
65ARAF0.63847349
66PTK20.62862957
67PRKD20.62740483
68MAP3K10.62083158
69MAPK130.60468163
70ZAP700.60432115
71ADRBK10.59630961
72RPS6KA20.57729005
73FGFR40.54554692
74AURKA0.53812430
75PRKD10.53140909
76CSNK1G10.51281883
77NEK90.50906511
78TESK10.49419971
79MAPK120.49080517
80MAP3K90.47457866
81PDGFRB0.47161915
82RAF10.46100137
83MAPK40.45605578
84MUSK0.44105665
85NEK20.42921161
86CHEK20.42321569
87CDC42BPA0.42260897
88TYRO30.40181699
89MAP2K20.39077652
90DYRK20.37863743
91PRKAA10.37761749
92MAP2K10.37313365
93EPHB10.36649907
94AURKB0.36007094
95PAK10.35955866
96BUB10.35868082
97STK30.35764744
98AKT20.35376564
99GRK50.34788642
100TEC0.34374410
101ROCK20.33937570
102PAK60.32450551
103CSNK1G30.31949198
104BMX0.31750548
105GSK3A0.30969420
106PNCK0.30003301
107INSR0.28872013
108ILK0.26201138
109CSNK1A1L0.26157971
110MARK20.26089948
111IRAK10.25718556
112SRC0.24793335
113PLK20.24286639
114MAP3K70.22958304
115HCK0.22933836
116PIK3CG0.22623398
117CAMK2A0.22541849
118MAP2K30.22293673
119ITK0.22207687
120MAP3K100.21957982
121PINK10.21919792
122MTOR0.21190798
123NUAK10.21184747
124RPS6KL10.21158356
125RPS6KC10.21158356
126PAK30.20624863
127YES10.20134185
128JAK30.19271332
129DDR20.19178433
130MAP4K10.18622166
131PDK20.18288892
132PKN10.17345742
133ABL10.17086561
134MAP2K40.16726226
135IGF1R0.16637762
136PDPK10.16580086
137EIF2AK20.16545670
138CAMK10.15676370
139EGFR0.14269007
140BCKDK0.14210151
141RPS6KA60.13412803
142FLT30.11270273
143DAPK30.11160689
144SMG10.10659086
145TBK10.10234682
146ADRBK20.09864094

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.11294587
2Arginine biosynthesis_Homo sapiens_hsa002202.92655773
3Dorso-ventral axis formation_Homo sapiens_hsa043202.81671935
4Prion diseases_Homo sapiens_hsa050202.51190718
5Complement and coagulation cascades_Homo sapiens_hsa046102.39600667
6ECM-receptor interaction_Homo sapiens_hsa045122.38754121
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.37937457
8Focal adhesion_Homo sapiens_hsa045102.19719179
9Dilated cardiomyopathy_Homo sapiens_hsa054142.06602301
10Vascular smooth muscle contraction_Homo sapiens_hsa042702.04598824
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97751119
12Adherens junction_Homo sapiens_hsa045201.95608526
13TGF-beta signaling pathway_Homo sapiens_hsa043501.91918952
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83976033
15Oocyte meiosis_Homo sapiens_hsa041141.79586895
16Notch signaling pathway_Homo sapiens_hsa043301.70764278
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69321854
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67906500
19Cell cycle_Homo sapiens_hsa041101.65860814
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.58341645
21Circadian rhythm_Homo sapiens_hsa047101.53584196
22Amoebiasis_Homo sapiens_hsa051461.47518702
23MicroRNAs in cancer_Homo sapiens_hsa052061.45589249
24Gap junction_Homo sapiens_hsa045401.42821759
25Pancreatic cancer_Homo sapiens_hsa052121.41810845
26HIF-1 signaling pathway_Homo sapiens_hsa040661.41032303
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38116864
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37820661
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.37081133
30Rap1 signaling pathway_Homo sapiens_hsa040151.33293859
31Small cell lung cancer_Homo sapiens_hsa052221.31371453
32Tight junction_Homo sapiens_hsa045301.28208802
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26772261
34Arginine and proline metabolism_Homo sapiens_hsa003301.24892641
35Hippo signaling pathway_Homo sapiens_hsa043901.24382773
36GnRH signaling pathway_Homo sapiens_hsa049121.23197176
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.22860414
38Fatty acid degradation_Homo sapiens_hsa000711.22127320
39VEGF signaling pathway_Homo sapiens_hsa043701.18988429
40Propanoate metabolism_Homo sapiens_hsa006401.16745338
41Platelet activation_Homo sapiens_hsa046111.13456753
42Tryptophan metabolism_Homo sapiens_hsa003801.12043693
43Ras signaling pathway_Homo sapiens_hsa040141.11127468
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09485403
45RNA degradation_Homo sapiens_hsa030181.06463652
46Bile secretion_Homo sapiens_hsa049761.04689653
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01588582
48PPAR signaling pathway_Homo sapiens_hsa033200.99739521
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99582693
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99565258
51Estrogen signaling pathway_Homo sapiens_hsa049150.95000014
52Linoleic acid metabolism_Homo sapiens_hsa005910.94896063
53Pertussis_Homo sapiens_hsa051330.94697505
54Phenylalanine metabolism_Homo sapiens_hsa003600.94103116
55PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89844008
56Renin secretion_Homo sapiens_hsa049240.87749631
57Other glycan degradation_Homo sapiens_hsa005110.85101774
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85024727
59Pathways in cancer_Homo sapiens_hsa052000.84340093
60Renal cell carcinoma_Homo sapiens_hsa052110.84225444
61Basal transcription factors_Homo sapiens_hsa030220.84113665
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83337925
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82767323
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80587914
65Oxytocin signaling pathway_Homo sapiens_hsa049210.79617645
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78103801
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.77228689
68Endocytosis_Homo sapiens_hsa041440.74627380
69cAMP signaling pathway_Homo sapiens_hsa040240.70933183
70Proteoglycans in cancer_Homo sapiens_hsa052050.70625446
71Protein digestion and absorption_Homo sapiens_hsa049740.69769376
72Choline metabolism in cancer_Homo sapiens_hsa052310.69516500
73Insulin signaling pathway_Homo sapiens_hsa049100.68783281
74Pyruvate metabolism_Homo sapiens_hsa006200.68466573
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.67675217
76Tyrosine metabolism_Homo sapiens_hsa003500.66385529
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64793506
78Fatty acid metabolism_Homo sapiens_hsa012120.62714705
79AMPK signaling pathway_Homo sapiens_hsa041520.61834783
80Toxoplasmosis_Homo sapiens_hsa051450.61804286
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61765808
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61153786
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.59569065
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57917875
85HTLV-I infection_Homo sapiens_hsa051660.57727915
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56830113
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56307803
88Glycerolipid metabolism_Homo sapiens_hsa005610.56055410
89Caffeine metabolism_Homo sapiens_hsa002320.55470960
90Ether lipid metabolism_Homo sapiens_hsa005650.55270134
91Viral myocarditis_Homo sapiens_hsa054160.53033500
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52698475
93Insulin resistance_Homo sapiens_hsa049310.51997528
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51781314
95Sulfur relay system_Homo sapiens_hsa041220.51646881
96Melanoma_Homo sapiens_hsa052180.51349787
97Chronic myeloid leukemia_Homo sapiens_hsa052200.50910472
98Axon guidance_Homo sapiens_hsa043600.50095578
99Malaria_Homo sapiens_hsa051440.49812063
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49146179
101Histidine metabolism_Homo sapiens_hsa003400.48789883
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48705265
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48401107
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48358513
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47810564
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45883356
107Melanogenesis_Homo sapiens_hsa049160.45370873
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45103544
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44794324
110MAPK signaling pathway_Homo sapiens_hsa040100.43189013
111beta-Alanine metabolism_Homo sapiens_hsa004100.40619337
112Colorectal cancer_Homo sapiens_hsa052100.39910527
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39629766
114Peroxisome_Homo sapiens_hsa041460.38949867
115Vitamin B6 metabolism_Homo sapiens_hsa007500.38350401
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36924921
117Prolactin signaling pathway_Homo sapiens_hsa049170.36706655
118Thyroid hormone synthesis_Homo sapiens_hsa049180.36672805
119Glucagon signaling pathway_Homo sapiens_hsa049220.35260224
120FoxO signaling pathway_Homo sapiens_hsa040680.34897991
121Shigellosis_Homo sapiens_hsa051310.34270437
122TNF signaling pathway_Homo sapiens_hsa046680.33836004
123Bladder cancer_Homo sapiens_hsa052190.33765406
124Thyroid cancer_Homo sapiens_hsa052160.33053680
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31790389
126Glioma_Homo sapiens_hsa052140.31729005
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.30962815
128Calcium signaling pathway_Homo sapiens_hsa040200.29816785
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29785553
130Salmonella infection_Homo sapiens_hsa051320.29410655
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27039826
132Staphylococcus aureus infection_Homo sapiens_hsa051500.25790510
133Cocaine addiction_Homo sapiens_hsa050300.25644840
134Gastric acid secretion_Homo sapiens_hsa049710.25457081

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