GJA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.71605149
2positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.15355099
3acrosome reaction (GO:0007340)4.68629955
4negative regulation of dendrite morphogenesis (GO:0050774)4.40680728
5snRNA processing (GO:0016180)4.22185547
6coenzyme catabolic process (GO:0009109)4.18557131
7protein localization to cilium (GO:0061512)4.15847526
8regulation of oxidative stress-induced neuron death (GO:1903203)4.04535830
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.91732226
10epithelial cilium movement (GO:0003351)3.89794804
11intraciliary transport (GO:0042073)3.85379193
12fucose catabolic process (GO:0019317)3.79831140
13L-fucose metabolic process (GO:0042354)3.79831140
14L-fucose catabolic process (GO:0042355)3.79831140
15snRNA metabolic process (GO:0016073)3.79811380
16negative regulation of nitric-oxide synthase activity (GO:0051001)3.79528567
17organic cation transport (GO:0015695)3.77365212
18adaptation of signaling pathway (GO:0023058)3.75952432
19negative regulation of dendrite development (GO:2000171)3.74805575
20regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.70101434
21regulation of acyl-CoA biosynthetic process (GO:0050812)3.48109999
22regulation of phosphoprotein phosphatase activity (GO:0043666)3.46095075
23axonemal dynein complex assembly (GO:0070286)3.45156083
24multicellular organism reproduction (GO:0032504)3.41159610
25terpenoid biosynthetic process (GO:0016114)3.33338124
26pyrimidine nucleobase catabolic process (GO:0006208)3.28639739
27regulation of cellular respiration (GO:0043457)3.28618876
28sperm motility (GO:0030317)3.27228988
29cellular response to zinc ion (GO:0071294)3.23136643
30cilium movement (GO:0003341)3.22205880
31tachykinin receptor signaling pathway (GO:0007217)3.20316164
32gamma-aminobutyric acid transport (GO:0015812)3.15628638
33protein polyglutamylation (GO:0018095)3.15465595
34positive regulation of megakaryocyte differentiation (GO:0045654)3.14299419
35ADP metabolic process (GO:0046031)3.13894827
36positive regulation of catecholamine secretion (GO:0033605)3.12050629
37positive regulation of glycolytic process (GO:0045821)3.09464604
38NIK/NF-kappaB signaling (GO:0038061)3.08841725
39regulation of cofactor metabolic process (GO:0051193)3.07273079
40regulation of coenzyme metabolic process (GO:0051196)3.07273079
41positive regulation of cAMP-mediated signaling (GO:0043950)3.06471395
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04390213
43neuron fate determination (GO:0048664)3.04103632
44cilium or flagellum-dependent cell motility (GO:0001539)3.02847570
45positive regulation of amine transport (GO:0051954)2.99218116
46regulation of chemokine-mediated signaling pathway (GO:0070099)2.98460425
47nerve growth factor signaling pathway (GO:0038180)2.98249188
48ventricular system development (GO:0021591)2.91044587
49cellular ketone body metabolic process (GO:0046950)2.90966568
50spermatid development (GO:0007286)2.89938304
51water-soluble vitamin biosynthetic process (GO:0042364)2.88756751
52cofactor catabolic process (GO:0051187)2.85709466
53oligosaccharide biosynthetic process (GO:0009312)2.85501397
54mitochondrion morphogenesis (GO:0070584)2.83782430
55positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.83094050
56membrane repolarization (GO:0086009)2.83069901
57potassium ion import (GO:0010107)2.81726074
58indole-containing compound catabolic process (GO:0042436)2.79844103
59indolalkylamine catabolic process (GO:0046218)2.79844103
60tryptophan catabolic process (GO:0006569)2.79844103
61regulation of glycolytic process (GO:0006110)2.77759693
62regulation of protein kinase A signaling (GO:0010738)2.70343960
63negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69190535
64mechanosensory behavior (GO:0007638)2.68323051
65motile cilium assembly (GO:0044458)2.67777139
66regulation of sulfur metabolic process (GO:0042762)2.67562676
67regulation of autophagic vacuole assembly (GO:2000785)2.67412448
68C4-dicarboxylate transport (GO:0015740)2.63836650
69neuron cell-cell adhesion (GO:0007158)2.62323616
70nucleobase catabolic process (GO:0046113)2.62138319
71transmission of nerve impulse (GO:0019226)2.62103618
72regulation of synaptic transmission, dopaminergic (GO:0032225)2.61586761
73activation of protein kinase B activity (GO:0032148)2.61496592
74negative regulation of oligodendrocyte differentiation (GO:0048715)2.60856442
75fatty acid elongation (GO:0030497)2.58390386
76glycerophospholipid catabolic process (GO:0046475)2.56896360
77regulation of potassium ion transmembrane transport (GO:1901379)2.55744471
78ketone body metabolic process (GO:1902224)2.52281766
79ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50029558
80mitochondrion degradation (GO:0000422)2.50018490
81regulation of cilium movement (GO:0003352)2.48267621
82calcium ion-dependent exocytosis (GO:0017156)2.48072550
83negative regulation of monooxygenase activity (GO:0032769)2.47280769
84positive regulation of uterine smooth muscle contraction (GO:0070474)2.47217517
85potassium ion export (GO:0071435)2.46358889
86adrenergic receptor signaling pathway (GO:0071875)2.45698275
87response to muscle activity (GO:0014850)2.45415738
88cilium assembly (GO:0042384)2.44154654
89mitotic cell cycle arrest (GO:0071850)2.43144589
90cilium organization (GO:0044782)2.42250106
91DNA deamination (GO:0045006)2.41941400
92positive regulation of triglyceride biosynthetic process (GO:0010867)2.39986458
93snRNA transcription (GO:0009301)2.39066881
94neuronal action potential propagation (GO:0019227)2.37233469
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.37031858
96regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.37009634
97single fertilization (GO:0007338)2.36769945
98positive regulation of potassium ion transport (GO:0043268)2.36694704
99protein K11-linked deubiquitination (GO:0035871)2.36595459
100cilium morphogenesis (GO:0060271)2.35823781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.41387302
2IGF1R_20145208_ChIP-Seq_DFB_Human3.55546989
3GBX2_23144817_ChIP-Seq_PC3_Human3.49377864
4ZNF274_21170338_ChIP-Seq_K562_Hela3.38411927
5VDR_22108803_ChIP-Seq_LS180_Human2.97284778
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85236724
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.60173003
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52334735
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26947661
10EZH2_22144423_ChIP-Seq_EOC_Human2.17229906
11FUS_26573619_Chip-Seq_HEK293_Human2.13736206
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04420998
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.01358284
14CBP_20019798_ChIP-Seq_JUKART_Human2.01358284
15P300_19829295_ChIP-Seq_ESCs_Human1.92898683
16GATA1_22025678_ChIP-Seq_K562_Human1.85722605
17TAF15_26573619_Chip-Seq_HEK293_Human1.75067346
18ER_23166858_ChIP-Seq_MCF-7_Human1.74448371
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73706643
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73319391
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72798693
22SMAD4_21799915_ChIP-Seq_A2780_Human1.65681381
23AR_25329375_ChIP-Seq_VCAP_Human1.64737672
24BCAT_22108803_ChIP-Seq_LS180_Human1.63678626
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59289026
26KLF5_20875108_ChIP-Seq_MESCs_Mouse1.56094172
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53528554
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51721165
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50349189
30SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49518155
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.47024400
32STAT3_23295773_ChIP-Seq_U87_Human1.46654670
33NANOG_19829295_ChIP-Seq_ESCs_Human1.44289749
34SOX2_19829295_ChIP-Seq_ESCs_Human1.44289749
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.39998846
36TP53_18474530_ChIP-ChIP_U2OS_Human1.38175064
37* TBL1_22424771_ChIP-Seq_293T_Human1.36515246
38RUNX2_22187159_ChIP-Seq_PCA_Human1.34746478
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30523155
40CJUN_26792858_Chip-Seq_BT549_Human1.29385851
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28678836
42TCF4_23295773_ChIP-Seq_U87_Human1.27099681
43IRF1_19129219_ChIP-ChIP_H3396_Human1.26873838
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26204012
45* PHF8_20622853_ChIP-Seq_HELA_Human1.25007633
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24380363
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.24351787
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23877981
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23862864
50RXR_22108803_ChIP-Seq_LS180_Human1.21509611
51* NFYB_21822215_ChIP-Seq_K562_Human1.20673433
52* EWS_26573619_Chip-Seq_HEK293_Human1.20058978
53* ETV1_20927104_ChIP-Seq_GIST48_Human1.19566867
54* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19283467
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18628809
56* NFYA_21822215_ChIP-Seq_K562_Human1.16560087
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14432293
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.14408104
59AR_21572438_ChIP-Seq_LNCaP_Human1.14175225
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13673755
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13673755
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13566570
63* HNFA_21074721_ChIP-Seq_CACO-2_Human1.13408226
64TCF4_22108803_ChIP-Seq_LS180_Human1.12664673
65* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12327100
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11737081
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.10992858
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09758357
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.09218202
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09167713
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08998066
72* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08307973
73REST_21632747_ChIP-Seq_MESCs_Mouse1.07748000
74AR_20517297_ChIP-Seq_VCAP_Human1.07090205
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.06414857
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04377030
77TP53_22573176_ChIP-Seq_HFKS_Human1.04009280
78* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03981632
79* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03735230
80* NCOR_22424771_ChIP-Seq_293T_Human1.03004178
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02943849
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02359989
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02359989
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.01267292
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01017723
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.99614001
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.99583136
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99492323
89* RBPJ_21746931_ChIP-Seq_IB4_Human0.99134680
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98553631
91* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98339020
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97532897
93MYC_19829295_ChIP-Seq_ESCs_Human0.97454393
94* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97082235
95* GATA6_21074721_ChIP-Seq_CACO-2_Human0.97044734
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96138650
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95633894
98CDX2_22108803_ChIP-Seq_LS180_Human0.95599962
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.95270918
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.94028907

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.53900891
2MP0005410_abnormal_fertilization3.12297442
3MP0005187_abnormal_penis_morphology3.07359228
4MP0005174_abnormal_tail_pigmentation2.82927812
5MP0003880_abnormal_central_pattern2.82031948
6MP0000015_abnormal_ear_pigmentation2.55814468
7MP0002139_abnormal_hepatobiliary_system2.50030121
8MP0008004_abnormal_stomach_pH2.36934415
9MP0002736_abnormal_nociception_after2.28499563
10MP0001984_abnormal_olfaction2.27440750
11MP0002837_dystrophic_cardiac_calcinosis2.18803723
12MP0005394_taste/olfaction_phenotype2.09646024
13MP0005499_abnormal_olfactory_system2.09646024
14MP0004885_abnormal_endolymph2.09398091
15MP0002254_reproductive_system_inflammat2.06306148
16MP0001529_abnormal_vocalization2.00585146
17MP0001968_abnormal_touch/_nociception1.95516636
18MP0002638_abnormal_pupillary_reflex1.91614763
19MP0002138_abnormal_hepatobiliary_system1.83852285
20MP0005645_abnormal_hypothalamus_physiol1.79621043
21MP0005423_abnormal_somatic_nervous1.77233610
22MP0003136_yellow_coat_color1.71874177
23MP0008789_abnormal_olfactory_epithelium1.71087366
24MP0003315_abnormal_perineum_morphology1.70267542
25MP0006072_abnormal_retinal_apoptosis1.67762630
26MP0005253_abnormal_eye_physiology1.63513253
27MP0008995_early_reproductive_senescence1.58911162
28MP0005248_abnormal_Harderian_gland1.56770770
29MP0009046_muscle_twitch1.53699151
30MP0005084_abnormal_gallbladder_morpholo1.53467467
31MP0010386_abnormal_urinary_bladder1.51809579
32MP0009745_abnormal_behavioral_response1.49979018
33MP0004133_heterotaxia1.48993492
34MP0005647_abnormal_sex_gland1.45838378
35MP0006276_abnormal_autonomic_nervous1.40411058
36MP0000631_abnormal_neuroendocrine_gland1.38935416
37MP0001905_abnormal_dopamine_level1.37102132
38MP0005058_abnormal_lysosome_morphology1.36969570
39MP0005646_abnormal_pituitary_gland1.35652635
40MP0003806_abnormal_nucleotide_metabolis1.33409787
41MP0001501_abnormal_sleep_pattern1.27736820
42MP0003633_abnormal_nervous_system1.27472103
43MP0002272_abnormal_nervous_system1.23522935
44MP0009697_abnormal_copulation1.22583728
45MP0005551_abnormal_eye_electrophysiolog1.18442787
46MP0004510_myositis1.17388548
47MP0003195_calcinosis1.16354497
48MP0004215_abnormal_myocardial_fiber1.14699529
49MP0003698_abnormal_male_reproductive1.13960116
50MP0002090_abnormal_vision1.13824467
51MP0001502_abnormal_circadian_rhythm1.13715966
52MP0003635_abnormal_synaptic_transmissio1.13637518
53MP0000647_abnormal_sebaceous_gland1.12302966
54MP0004270_analgesia1.11929591
55MP0003385_abnormal_body_wall1.11077975
56MP0003137_abnormal_impulse_conducting1.10557386
57MP0000372_irregular_coat_pigmentation1.09766184
58MP0002822_catalepsy1.08851525
59MP0002735_abnormal_chemical_nociception1.08468517
60MP0003879_abnormal_hair_cell1.07102021
61MP0003011_delayed_dark_adaptation1.05986235
62MP0001764_abnormal_homeostasis1.05033917
63MP0002102_abnormal_ear_morphology1.02195264
64MP0005367_renal/urinary_system_phenotyp1.01589756
65MP0000516_abnormal_urinary_system1.01589756
66MP0002295_abnormal_pulmonary_circulatio0.99572840
67MP0002067_abnormal_sensory_capabilities0.99507538
68MP0003631_nervous_system_phenotype0.97386894
69MP0000749_muscle_degeneration0.96920335
70MP0003172_abnormal_lysosome_physiology0.96157596
71MP0002063_abnormal_learning/memory/cond0.94662440
72MP0002160_abnormal_reproductive_system0.94560165
73MP0002572_abnormal_emotion/affect_behav0.93799484
74MP0002095_abnormal_skin_pigmentation0.93418154
75MP0005379_endocrine/exocrine_gland_phen0.92342342
76MP0001970_abnormal_pain_threshold0.90891096
77MP0000230_abnormal_systemic_arterial0.90886872
78MP0002557_abnormal_social/conspecific_i0.88255260
79MP0009764_decreased_sensitivity_to0.86444644
80MP0000778_abnormal_nervous_system0.85923804
81MP0000026_abnormal_inner_ear0.85339124
82MP0001986_abnormal_taste_sensitivity0.85201051
83MP0000604_amyloidosis0.84824436
84MP0002064_seizures0.84118590
85MP0001486_abnormal_startle_reflex0.82911071
86MP0004859_abnormal_synaptic_plasticity0.82668695
87MP0001919_abnormal_reproductive_system0.79632311
88MP0002733_abnormal_thermal_nociception0.79152709
89MP0005365_abnormal_bile_salt0.79042042
90MP0005386_behavior/neurological_phenoty0.77987558
91MP0004924_abnormal_behavior0.77987558
92MP0002163_abnormal_gland_morphology0.77741834
93MP0002876_abnormal_thyroid_physiology0.77304567
94MP0001929_abnormal_gametogenesis0.77205320
95MP0005332_abnormal_amino_acid0.73541546
96MP0002938_white_spotting0.70711836
97MP0004085_abnormal_heartbeat0.70592765
98MP0002184_abnormal_innervation0.70099059
99MP0004811_abnormal_neuron_physiology0.69904490
100MP0002752_abnormal_somatic_nervous0.69787178

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)4.28713402
2Febrile seizures (HP:0002373)3.80666918
3Inability to walk (HP:0002540)3.66700567
4Tubular atrophy (HP:0000092)3.66049440
5Pancreatic cysts (HP:0001737)3.53497997
6Recurrent corneal erosions (HP:0000495)3.49371985
7Nephronophthisis (HP:0000090)3.42859214
8Severe visual impairment (HP:0001141)3.32525636
9Fibular aplasia (HP:0002990)3.23951955
10Abnormality of glycolipid metabolism (HP:0010969)3.21314825
11Abnormality of liposaccharide metabolism (HP:0010968)3.21314825
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.21314825
13Abnormal ciliary motility (HP:0012262)3.12277988
14Absent speech (HP:0001344)3.10120361
15True hermaphroditism (HP:0010459)3.08299061
16Atonic seizures (HP:0010819)2.92249075
17Short tibia (HP:0005736)2.91042495
18Aplasia/Hypoplasia of the tibia (HP:0005772)2.89450074
19Pancreatic fibrosis (HP:0100732)2.88573413
20Abnormality of the renal medulla (HP:0100957)2.87172089
21Aplasia/hypoplasia of the uterus (HP:0008684)2.86210201
22Dynein arm defect of respiratory motile cilia (HP:0012255)2.83624093
23Absent/shortened dynein arms (HP:0200106)2.83624093
24Hyperventilation (HP:0002883)2.81602302
25Retinal dysplasia (HP:0007973)2.78663950
26Cerebellar dysplasia (HP:0007033)2.78649913
27Abnormal respiratory motile cilium morphology (HP:0005938)2.70857970
28Abnormal respiratory epithelium morphology (HP:0012253)2.70857970
29Tubulointerstitial nephritis (HP:0001970)2.68503245
30Abnormal respiratory motile cilium physiology (HP:0012261)2.66747034
31Polydipsia (HP:0001959)2.65379313
32Abnormal drinking behavior (HP:0030082)2.65379313
33Hemiparesis (HP:0001269)2.62139795
34Thyroid-stimulating hormone excess (HP:0002925)2.60160430
35Hypoplasia of the uterus (HP:0000013)2.48691567
36Type II lissencephaly (HP:0007260)2.48159939
37Fibular hypoplasia (HP:0003038)2.45976320
38Nonprogressive disorder (HP:0003680)2.43556926
39Occipital encephalocele (HP:0002085)2.42920053
40Short 1st metacarpal (HP:0010034)2.38430954
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.38430954
42Retinal atrophy (HP:0001105)2.36355579
43Medial flaring of the eyebrow (HP:0010747)2.35591099
44Lissencephaly (HP:0001339)2.34588445
45Spastic tetraplegia (HP:0002510)2.34067355
46Resting tremor (HP:0002322)2.32882128
47Chronic hepatic failure (HP:0100626)2.31857357
48Aplasia/Hypoplasia of the fibula (HP:0006492)2.31686157
49Renal dysplasia (HP:0000110)2.30712981
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.26352677
51Nephrogenic diabetes insipidus (HP:0009806)2.25088078
52Gait imbalance (HP:0002141)2.21892898
53Mesangial abnormality (HP:0001966)2.16936118
54Exercise-induced muscle cramps (HP:0003710)2.16646785
55Congenital primary aphakia (HP:0007707)2.16410437
56Enlarged kidneys (HP:0000105)2.16084573
57Abnormality of the renal cortex (HP:0011035)2.15806331
58Congenital hepatic fibrosis (HP:0002612)2.14601145
59Reduced antithrombin III activity (HP:0001976)2.12568954
60Progressive cerebellar ataxia (HP:0002073)2.09931063
61Severe muscular hypotonia (HP:0006829)2.09271337
62Abnormality of midbrain morphology (HP:0002418)2.04954395
63Molar tooth sign on MRI (HP:0002419)2.04954395
64Sensory axonal neuropathy (HP:0003390)2.04953786
65Alacrima (HP:0000522)2.02524980
66Male pseudohermaphroditism (HP:0000037)2.02366160
67Abnormality of the 1st metacarpal (HP:0010009)2.01978229
68Drooling (HP:0002307)2.01294856
69Prolonged neonatal jaundice (HP:0006579)1.99407033
70Tubulointerstitial abnormality (HP:0001969)1.97893612
71Urinary urgency (HP:0000012)1.94592232
72Epileptic encephalopathy (HP:0200134)1.93563843
73Decreased lacrimation (HP:0000633)1.92839337
74Anencephaly (HP:0002323)1.91699717
75Postaxial foot polydactyly (HP:0001830)1.91680576
76Eosinophilia (HP:0001880)1.91532078
77Aplasia/hypoplasia of the humerus (HP:0006507)1.91347638
78Clumsiness (HP:0002312)1.90331109
79Poor head control (HP:0002421)1.89887251
80Postaxial hand polydactyly (HP:0001162)1.87956684
81Postural instability (HP:0002172)1.87358253
82Lipid accumulation in hepatocytes (HP:0006561)1.85962394
83Hypothermia (HP:0002045)1.84538486
84Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83844053
85Abnormal rod and cone electroretinograms (HP:0008323)1.83123183
86Excessive salivation (HP:0003781)1.81141679
87Stage 5 chronic kidney disease (HP:0003774)1.79818331
88Cystic liver disease (HP:0006706)1.79004713
89Abnormal albumin level (HP:0012116)1.78359408
90Hypoalbuminemia (HP:0003073)1.78359408
91Protruding tongue (HP:0010808)1.75307705
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75106480
93Pachygyria (HP:0001302)1.74181924
94Vacuolated lymphocytes (HP:0001922)1.74008480
95Polyuria (HP:0000103)1.72866555
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71459506
97Congenital sensorineural hearing impairment (HP:0008527)1.70146918
98Polyphagia (HP:0002591)1.69862945
99Albinism (HP:0001022)1.69447997
100Fair hair (HP:0002286)1.66955810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.57282468
2WNK42.76449682
3CASK2.65227777
4MAP2K72.48769853
5TRIM282.48638258
6STK392.42929208
7DYRK32.39436519
8FRK2.27242075
9ADRBK22.26404334
10MARK32.05284047
11BMPR1B1.97306650
12CAMKK21.97141017
13WNK31.94863887
14MAPK131.91620668
15TLK11.89268093
16ACVR1B1.74429184
17MAP4K21.73614111
18MAP3K41.70906195
19MARK11.66734393
20CSNK1G31.59301611
21EPHA31.57734203
22STK38L1.56031763
23RPS6KA51.55955395
24CSNK1A1L1.53633548
25ZAK1.52973961
26PRKCQ1.44364035
27PRKD31.43163021
28MST41.41981734
29CSNK1G21.40774961
30BCR1.34865115
31RPS6KA41.33912152
32OBSCN1.29165546
33CSNK1G11.27549448
34WNK11.24693271
35FGR1.21922648
36LATS11.21064018
37BRD41.19543157
38MYLK1.17157075
39STK381.16888462
40TAOK11.13832729
41GRK71.10789549
42PAK31.09118590
43SGK4941.06332862
44SGK2231.06332862
45PLK21.04029624
46TNIK1.03767528
47DYRK20.95534034
48SGK20.95276188
49PIM20.94610760
50NUAK10.93865767
51GRK10.89218165
52IKBKE0.86484139
53PKN10.78837020
54MAP3K50.77812032
55MAP2K60.75268447
56PRKCE0.73934217
57FER0.72950970
58BRSK20.71006599
59LIMK10.70795925
60YES10.70564245
61TESK10.70004714
62CCNB10.69690501
63STK160.66519007
64CAMK2B0.65727826
65CDK30.65473069
66BCKDK0.63264237
67ADRBK10.63132611
68PHKG20.62605040
69PHKG10.62605040
70LMTK20.62355997
71SRPK10.62182805
72DDR20.61849104
73IRAK10.53827442
74IRAK20.52850537
75ROCK10.52582469
76CAMK2A0.51303159
77NTRK20.49294651
78CSNK1D0.47979442
79AKT30.47865496
80PRKCG0.47713292
81CDK140.45228794
82EGFR0.44837134
83CAMK40.43825456
84CSNK1A10.43626954
85KDR0.42286482
86PRKG10.41856101
87CDK50.40283723
88DYRK1B0.40014698
89EPHA40.39557056
90MAP2K40.38777319
91MAPKAPK30.38135459
92CAMK2D0.35253695
93SIK30.33956595
94MINK10.32526519
95CAMK2G0.30158629
96MAPK150.30150764
97TESK20.29056051
98PRKACA0.27958485
99INSRR0.25882922
100PTK2B0.24447532

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.34235450
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.29867954
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.24093540
4Butanoate metabolism_Homo sapiens_hsa006502.84250148
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.64652349
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.57219128
7Circadian rhythm_Homo sapiens_hsa047102.12776391
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10644387
9Regulation of autophagy_Homo sapiens_hsa041402.10053619
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.96094048
11Steroid biosynthesis_Homo sapiens_hsa001001.90594304
12Sphingolipid metabolism_Homo sapiens_hsa006001.85330871
13Olfactory transduction_Homo sapiens_hsa047401.66750554
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65191330
15Nitrogen metabolism_Homo sapiens_hsa009101.64452433
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.63998309
17Nicotine addiction_Homo sapiens_hsa050331.63271907
18GABAergic synapse_Homo sapiens_hsa047271.54368037
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52250874
20Protein export_Homo sapiens_hsa030601.48659800
21Phototransduction_Homo sapiens_hsa047441.47552206
22Collecting duct acid secretion_Homo sapiens_hsa049661.45231895
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.39844687
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29103601
25Synaptic vesicle cycle_Homo sapiens_hsa047211.26789552
26Gap junction_Homo sapiens_hsa045401.26777576
27Propanoate metabolism_Homo sapiens_hsa006401.25405096
28Other glycan degradation_Homo sapiens_hsa005111.23651730
29Morphine addiction_Homo sapiens_hsa050321.21057304
30Circadian entrainment_Homo sapiens_hsa047131.18231464
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15872235
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14042746
33Selenocompound metabolism_Homo sapiens_hsa004501.12280758
34Peroxisome_Homo sapiens_hsa041461.07874076
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06155411
36Ether lipid metabolism_Homo sapiens_hsa005651.04142241
37beta-Alanine metabolism_Homo sapiens_hsa004101.03990753
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02804879
39Amphetamine addiction_Homo sapiens_hsa050311.01806237
40Fatty acid metabolism_Homo sapiens_hsa012121.01029549
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98777550
42Cocaine addiction_Homo sapiens_hsa050300.98608356
43Glutamatergic synapse_Homo sapiens_hsa047240.98343781
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97969992
45Phagosome_Homo sapiens_hsa041450.95073076
46PPAR signaling pathway_Homo sapiens_hsa033200.92535742
47Lysosome_Homo sapiens_hsa041420.91414837
48Basal transcription factors_Homo sapiens_hsa030220.90540778
49Renin secretion_Homo sapiens_hsa049240.90079639
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89457742
51Dopaminergic synapse_Homo sapiens_hsa047280.86275645
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85148160
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.83280462
54Insulin secretion_Homo sapiens_hsa049110.79281172
55ABC transporters_Homo sapiens_hsa020100.76866017
56Taste transduction_Homo sapiens_hsa047420.76427855
57Hedgehog signaling pathway_Homo sapiens_hsa043400.75358017
58Alcoholism_Homo sapiens_hsa050340.74230346
59Shigellosis_Homo sapiens_hsa051310.73130707
60Fatty acid biosynthesis_Homo sapiens_hsa000610.70018730
61Serotonergic synapse_Homo sapiens_hsa047260.68227993
62Linoleic acid metabolism_Homo sapiens_hsa005910.66990616
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65692701
64Mineral absorption_Homo sapiens_hsa049780.65459929
65Sulfur metabolism_Homo sapiens_hsa009200.62167761
66Calcium signaling pathway_Homo sapiens_hsa040200.61936652
67Salivary secretion_Homo sapiens_hsa049700.61594140
68Chemical carcinogenesis_Homo sapiens_hsa052040.60110185
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59429138
70Ovarian steroidogenesis_Homo sapiens_hsa049130.59344294
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59119423
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56392835
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56308871
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56270952
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54701541
76Vibrio cholerae infection_Homo sapiens_hsa051100.54041158
77Oxidative phosphorylation_Homo sapiens_hsa001900.53290892
78Oxytocin signaling pathway_Homo sapiens_hsa049210.52861937
79Tryptophan metabolism_Homo sapiens_hsa003800.52012291
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50494240
81Metabolic pathways_Homo sapiens_hsa011000.49129806
82Retinol metabolism_Homo sapiens_hsa008300.47902109
83Vitamin B6 metabolism_Homo sapiens_hsa007500.46458762
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45961418
85Purine metabolism_Homo sapiens_hsa002300.44504014
86Dorso-ventral axis formation_Homo sapiens_hsa043200.41917516
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41575336
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41285972
89cAMP signaling pathway_Homo sapiens_hsa040240.39794946
90Gastric acid secretion_Homo sapiens_hsa049710.39698171
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.39008520
92Fatty acid degradation_Homo sapiens_hsa000710.36746907
93Rheumatoid arthritis_Homo sapiens_hsa053230.36722904
94Fanconi anemia pathway_Homo sapiens_hsa034600.36486569
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36378145
96Systemic lupus erythematosus_Homo sapiens_hsa053220.35727036
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34527617
98Arachidonic acid metabolism_Homo sapiens_hsa005900.33765638
99Fatty acid elongation_Homo sapiens_hsa000620.32641256
100Type II diabetes mellitus_Homo sapiens_hsa049300.32401323

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