GJB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.84825329
2bundle of His cell to Purkinje myocyte communication (GO:0086069)8.83273946
3keratinocyte proliferation (GO:0043616)8.68658282
4molting cycle (GO:0042303)8.16108338
5hair cycle (GO:0042633)8.16108338
6peptide cross-linking (GO:0018149)7.74065988
7epidermal cell differentiation (GO:0009913)7.49394160
8multicellular organismal water homeostasis (GO:0050891)7.41139666
9L-phenylalanine catabolic process (GO:0006559)7.33817896
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.33817896
11L-phenylalanine metabolic process (GO:0006558)7.01443675
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.01443675
13epidermis development (GO:0008544)6.94157671
14intermediate filament organization (GO:0045109)6.61944493
15aromatic amino acid family catabolic process (GO:0009074)6.59511857
16water homeostasis (GO:0030104)6.17988648
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03345564
18tryptophan catabolic process (GO:0006569)5.97785893
19indole-containing compound catabolic process (GO:0042436)5.97785893
20indolalkylamine catabolic process (GO:0046218)5.97785893
21kynurenine metabolic process (GO:0070189)5.87612784
22bile acid biosynthetic process (GO:0006699)5.71988832
23surfactant homeostasis (GO:0043129)5.66300010
24tryptophan metabolic process (GO:0006568)5.63692736
25glyoxylate metabolic process (GO:0046487)5.60779538
26urea metabolic process (GO:0019627)5.51188787
27urea cycle (GO:0000050)5.51188787
28alpha-linolenic acid metabolic process (GO:0036109)5.49825009
29negative regulation of fibrinolysis (GO:0051918)5.47957433
30negative regulation of keratinocyte proliferation (GO:0010839)5.43689075
31skin morphogenesis (GO:0043589)5.36670580
32high-density lipoprotein particle remodeling (GO:0034375)5.34734799
33cysteine metabolic process (GO:0006534)5.34618552
34detection of bacterium (GO:0016045)5.33873442
35regulation of protein activation cascade (GO:2000257)5.27254416
36sulfur amino acid catabolic process (GO:0000098)5.25334959
37peptidyl-glutamic acid carboxylation (GO:0017187)5.23480484
38protein carboxylation (GO:0018214)5.23480484
39regulation of fibrinolysis (GO:0051917)5.23456836
40complement activation, alternative pathway (GO:0006957)5.23103058
41long-chain fatty acid biosynthetic process (GO:0042759)5.22325177
42intermediate filament cytoskeleton organization (GO:0045104)5.18890620
43nitrogen cycle metabolic process (GO:0071941)5.04716146
44intermediate filament-based process (GO:0045103)5.00882758
45lipoxygenase pathway (GO:0019372)4.99491035
46detection of other organism (GO:0098543)4.96871786
47serine family amino acid catabolic process (GO:0009071)4.94969802
48regulation of complement activation (GO:0030449)4.93242405
49bile acid metabolic process (GO:0008206)4.86478252
50aromatic amino acid family metabolic process (GO:0009072)4.81846970
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.77901284
52tyrosine metabolic process (GO:0006570)4.75991914
53homocysteine metabolic process (GO:0050667)4.73231591
54reverse cholesterol transport (GO:0043691)4.72233548
55regulation of triglyceride catabolic process (GO:0010896)4.68516169
56linoleic acid metabolic process (GO:0043651)4.67865583
57chemical homeostasis within a tissue (GO:0048875)4.67834701
58lysine metabolic process (GO:0006553)4.67448010
59lysine catabolic process (GO:0006554)4.67448010
60positive regulation of epidermis development (GO:0045684)4.63747966
61regulation of cholesterol esterification (GO:0010872)4.60867599
62plasma lipoprotein particle remodeling (GO:0034369)4.56931248
63protein-lipid complex remodeling (GO:0034368)4.56931248
64macromolecular complex remodeling (GO:0034367)4.56931248
65cell-substrate junction assembly (GO:0007044)4.53441860
66amino-acid betaine metabolic process (GO:0006577)4.48631074
67alpha-amino acid catabolic process (GO:1901606)4.47872782
68positive regulation of monocyte chemotaxis (GO:0090026)4.45568146
69phospholipid efflux (GO:0033700)4.45471690
70triglyceride homeostasis (GO:0070328)4.43283991
71acylglycerol homeostasis (GO:0055090)4.43283991
72negative regulation of cholesterol transport (GO:0032375)4.39502545
73negative regulation of sterol transport (GO:0032372)4.39502545
74negative regulation of interferon-gamma production (GO:0032689)4.35346102
75establishment of planar polarity (GO:0001736)4.31865745
76establishment of tissue polarity (GO:0007164)4.31865745
77keratinocyte development (GO:0003334)4.31569105
78positive regulation of epidermal cell differentiation (GO:0045606)4.25750242
79cellular ketone body metabolic process (GO:0046950)4.25433541
80ectoderm development (GO:0007398)4.24857002
81bile acid and bile salt transport (GO:0015721)4.20915817
82indolalkylamine metabolic process (GO:0006586)4.20177356
83plasma lipoprotein particle clearance (GO:0034381)4.20044439
84glycine metabolic process (GO:0006544)4.18421182
85regulation of keratinocyte proliferation (GO:0010837)4.18099257
86regulation of natural killer cell differentiation (GO:0032823)4.16795099
87coenzyme catabolic process (GO:0009109)4.16547263
88cellular glucuronidation (GO:0052695)4.14983255
89glutamate metabolic process (GO:0006536)4.14049515
90cellular amino acid catabolic process (GO:0009063)4.13625242
91imidazole-containing compound metabolic process (GO:0052803)4.12369100
92cellular modified amino acid catabolic process (GO:0042219)4.11215410
93epithelial cell differentiation involved in prostate gland development (GO:0060742)4.10298396
94amine catabolic process (GO:0009310)4.09837854
95cellular biogenic amine catabolic process (GO:0042402)4.09837854
96fibrinolysis (GO:0042730)4.06960933
97serine family amino acid metabolic process (GO:0009069)4.05266610
98cholesterol efflux (GO:0033344)3.99487380
99benzene-containing compound metabolic process (GO:0042537)3.97659713
100ethanol oxidation (GO:0006069)3.94081538
101plasma lipoprotein particle assembly (GO:0034377)3.91166658
102dicarboxylic acid biosynthetic process (GO:0043650)3.87850000
103arginine metabolic process (GO:0006525)3.86735495
104serine family amino acid biosynthetic process (GO:0009070)3.85942989
105phosphatidylserine acyl-chain remodeling (GO:0036150)3.83569629
106drug catabolic process (GO:0042737)3.83192577
107regulation of cholesterol homeostasis (GO:2000188)3.80760114
108regulation of hair follicle development (GO:0051797)3.79797524
109low-density lipoprotein particle remodeling (GO:0034374)3.78592374
110ketone body metabolic process (GO:1902224)3.76366947
111phospholipid homeostasis (GO:0055091)3.74049541
112very-low-density lipoprotein particle assembly (GO:0034379)3.73729572
113phosphatidylinositol acyl-chain remodeling (GO:0036149)3.73034947
114glucuronate metabolic process (GO:0019585)3.67466313
115uronic acid metabolic process (GO:0006063)3.67466313
116complement activation (GO:0006956)3.66787688
117regulation of bile acid biosynthetic process (GO:0070857)3.66284306
118positive regulation of lipoprotein lipase activity (GO:0051006)3.66027730
119positive regulation of triglyceride lipase activity (GO:0061365)3.66027730
120complement activation, classical pathway (GO:0006958)3.65013306
121aldehyde catabolic process (GO:0046185)3.63710957
122positive regulation of hair follicle development (GO:0051798)3.63110744
123positive regulation of hair cycle (GO:0042635)3.63110744
124cholesterol homeostasis (GO:0042632)3.63086343
125positive regulation of lipid catabolic process (GO:0050996)3.62679015
126short-chain fatty acid metabolic process (GO:0046459)3.61837624
127acetyl-CoA metabolic process (GO:0006084)3.61481250
128protein activation cascade (GO:0072376)3.61431994
129carboxylic acid catabolic process (GO:0046395)3.61067459
130organic acid catabolic process (GO:0016054)3.61067459
131sterol homeostasis (GO:0055092)3.58139075
132blood coagulation, intrinsic pathway (GO:0007597)3.57258755
133negative regulation of lipase activity (GO:0060192)3.56501990
134protein-lipid complex assembly (GO:0065005)3.54490072
135cytolysis (GO:0019835)3.52636483
136cofactor catabolic process (GO:0051187)3.52170846
137plasma lipoprotein particle organization (GO:0071827)3.51986358
138regulation of plasminogen activation (GO:0010755)3.51506323
139acute-phase response (GO:0006953)3.48911010
140polarized epithelial cell differentiation (GO:0030859)3.48622240
141regulation of epidermis development (GO:0045682)3.48239267
142regulation of vitamin D biosynthetic process (GO:0060556)3.40586678
143negative regulation of interleukin-17 production (GO:0032700)3.40286736
144sequestering of metal ion (GO:0051238)3.39069208
145regulation of monocyte chemotaxis (GO:0090025)3.33802382
146regulation of keratinocyte differentiation (GO:0045616)3.30106467
147protein localization to endosome (GO:0036010)3.26358920
148positive regulation of keratinocyte differentiation (GO:0045618)3.23694416
149epithelium development (GO:0060429)3.20944568
150cell adhesion mediated by integrin (GO:0033627)3.14109395
151ventricular cardiac muscle cell action potential (GO:0086005)3.12908117
152positive regulation of T cell chemotaxis (GO:0010820)3.11370404
153regulation of T cell chemotaxis (GO:0010819)3.11370404
154hair follicle morphogenesis (GO:0031069)3.04489689
155phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.01786853
156detection of external biotic stimulus (GO:0098581)2.99779341
157lateral sprouting from an epithelium (GO:0060601)2.98490600
158regulation of hair cycle (GO:0042634)2.97588371
159phosphatidylserine metabolic process (GO:0006658)2.91494205
160phosphatidylcholine acyl-chain remodeling (GO:0036151)2.86882357
161dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84352890
162regulation of vitamin metabolic process (GO:0030656)2.82572202
163intestinal epithelial cell development (GO:0060576)2.81657380
164phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.80007782
165regulation of epidermal cell differentiation (GO:0045604)2.79427074
166hypotonic response (GO:0006971)2.73163550
167regulation of heart rate by cardiac conduction (GO:0086091)2.64247899
168positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.58208788
169detection of biotic stimulus (GO:0009595)2.57158945
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55901590
171atrioventricular valve morphogenesis (GO:0003181)2.55686811
172positive regulation of granulocyte chemotaxis (GO:0071624)2.49802825
173negative regulation of epidermis development (GO:0045683)2.48655217
174regulation of natural killer cell activation (GO:0032814)2.47781780
175regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47405833
176negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47354836
177skin development (GO:0043588)2.47072725
178regulation of transforming growth factor beta2 production (GO:0032909)2.44926369
179alditol phosphate metabolic process (GO:0052646)2.43773660
180cell communication involved in cardiac conduction (GO:0086065)2.40140959
181negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.37583840
182wound healing (GO:0042060)2.36893279
183epithelial cell proliferation (GO:0050673)2.36596645
184regulation of membrane protein ectodomain proteolysis (GO:0051043)2.35129570
185sphingosine metabolic process (GO:0006670)2.33033408
186ceramide biosynthetic process (GO:0046513)2.30310100
187negative regulation of chondrocyte differentiation (GO:0032331)2.30177902
188epithelial cell-cell adhesion (GO:0090136)2.30104127
189hair cycle process (GO:0022405)2.27817082
190molting cycle process (GO:0022404)2.27817082
191positive regulation of protein export from nucleus (GO:0046827)2.27049542
192regulation of protein localization to cell surface (GO:2000008)2.26771012
193negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.23937887
194keratinization (GO:0031424)16.5156225
195establishment of skin barrier (GO:0061436)12.9290309
196desmosome organization (GO:0002934)12.5861808
197hemidesmosome assembly (GO:0031581)12.3629081
198regulation of water loss via skin (GO:0033561)11.5298672

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.85410836
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.79009806
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.32187563
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.16385185
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.93267212
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.65786733
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.50718380
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.29677892
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85566306
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.39394516
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.93177007
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.93177007
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46080046
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.23285999
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01730733
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1553534
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93721902
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92276142
19CLOCK_20551151_ChIP-Seq_293T_Human1.88463880
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86164452
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83830626
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76623564
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.76496622
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.66150795
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56021893
26UBF1/2_26484160_Chip-Seq_HMECs_Human1.53348779
27ATF3_27146783_Chip-Seq_COLON_Human1.52693732
28TP63_22573176_ChIP-Seq_HFKS_Human1.49390272
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35833235
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34882421
31HNF4A_19822575_ChIP-Seq_HepG2_Human1.33699378
32HTT_18923047_ChIP-ChIP_STHdh_Human1.33595213
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31955138
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27940253
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27863980
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.25276500
37CJUN_26792858_Chip-Seq_BT549_Human1.21018370
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19937663
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.16668836
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15305718
41KLF5_25053715_ChIP-Seq_YYC3_Human1.14189460
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.14123841
43JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13351905
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11092869
45GATA1_22025678_ChIP-Seq_K562_Human1.10982245
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10645506
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07219989
48GATA4_25053715_ChIP-Seq_YYC3_Human1.06431719
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03334119
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.01061952
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00518817
52TP53_18474530_ChIP-ChIP_U2OS_Human0.99646212
53TCF4_18268006_ChIP-ChIP_LS174T_Human0.98871200
54TRIM28_21343339_ChIP-Seq_HEK293_Human0.98648948
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98003675
56ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96429617
57P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96135075
58RUNX1_27514584_Chip-Seq_MCF-7_Human0.94518322
59FOXO3_23340844_ChIP-Seq_DLD1_Human0.93466681
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93413263
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93313931
62ZNF263_19887448_ChIP-Seq_K562_Human0.93102024
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88248689
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87008593
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86996773
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85301510
67MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84637836
68EGR1_19032775_ChIP-ChIP_M12_Human0.83224034
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82525150
70SMAD_19615063_ChIP-ChIP_OVARY_Human0.81927458
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80437995
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79375004
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77380283
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77031805
75* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76105982
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76023076
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75898925
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75564550
79RXR_22108803_ChIP-Seq_LS180_Human0.75428285
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.75020917
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74555155
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73916389
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73593475
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.73528999
85* LXR_22292898_ChIP-Seq_THP-1_Human0.72622343
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72176141
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72176141
88TBX20_22080862_ChIP-Seq_HEART_Mouse0.70642751
89TBX20_22328084_ChIP-Seq_HEART_Mouse0.70642751
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70627066
91P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.69876054
92IRF8_27001747_Chip-Seq_BMDM_Mouse0.69091350
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68369328
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68120970
95CEBPB_22108803_ChIP-Seq_LS180_Human0.67987673
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.67947357
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.67806237
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.67390844
99KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66912646
100AHR_22903824_ChIP-Seq_MCF-7_Human0.66352866
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66302142
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.66246245
103RARA_24833708_ChIP-Seq_LIVER_Mouse0.66147928
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66074039
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.64980429
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.64850653
107CTCF_27219007_Chip-Seq_Bcells_Human0.64823976
108* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64198887
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.63918244
110GATA6_25053715_ChIP-Seq_YYC3_Human0.63265452
111* SOX2_20726797_ChIP-Seq_SW620_Human0.63002020
112SMC4_20622854_ChIP-Seq_HELA_Human0.62977801
113RACK7_27058665_Chip-Seq_MCF-7_Human0.62835476
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.62709719
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.62046022
116TP53_16413492_ChIP-PET_HCT116_Human0.62040058
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.61933690
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60947663
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60528111
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60360769
121* BCOR_27268052_Chip-Seq_Bcells_Human0.60298650
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59459193
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58188139
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.58109845
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57749952
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57517604
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56825308
128* RARB_24833708_ChIP-Seq_LIVER_Mouse0.56248215
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.54398804
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.54138446
131P53_21459846_ChIP-Seq_SAOS-2_Human0.52730213
132TAF2_19829295_ChIP-Seq_ESCs_Human0.52072566
133FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.52043365
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.51401702
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51147532
136* ERG_21242973_ChIP-ChIP_JURKAT_Human0.50573348
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49685631
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49380117
139GATA2_19941826_ChIP-Seq_K562_Human0.49063334
140* MYC_19915707_ChIP-ChIP_AK7_Human0.48939394
141AR_20517297_ChIP-Seq_VCAP_Human0.48900642
142BCAT_22108803_ChIP-Seq_LS180_Human0.48803548
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.48771455
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48603565
145TP63_23658742_ChIP-Seq_EP156T_Human0.48444354
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.48204364
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48093896
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.48064966
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.47144181
150CBP_21632823_ChIP-Seq_H3396_Human0.47051458
151CSB_26484114_Chip-Seq_FIBROBLAST_Human0.46813231
152ERG_20517297_ChIP-Seq_VCAP_Human0.46249655
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45804786
154GATA1_19941826_ChIP-Seq_K562_Human0.45712648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.86704105
2MP0005360_urolithiasis7.35035527
3MP0005085_abnormal_gallbladder_physiolo6.16972377
4MP0005365_abnormal_bile_salt5.89246167
5MP0008875_abnormal_xenobiotic_pharmacok4.78248309
6MP0003806_abnormal_nucleotide_metabolis3.82574888
7MP0003252_abnormal_bile_duct3.78901321
8MP0003941_abnormal_skin_development3.65365605
9MP0010329_abnormal_lipoprotein_level3.42912322
10MP0009840_abnormal_foam_cell3.12586684
11MP0005083_abnormal_biliary_tract3.04741599
12MP0005332_abnormal_amino_acid2.69375163
13MP0003195_calcinosis2.63434741
14MP0000762_abnormal_tongue_morphology2.63304678
15MP0001666_abnormal_nutrient_absorption2.62145514
16MP0003566_abnormal_cell_adhesion2.54965810
17* MP0010771_integument_phenotype2.49171261
18MP0005409_darkened_coat_color2.35964423
19MP0003191_abnormal_cellular_cholesterol2.34652292
20MP0004019_abnormal_vitamin_homeostasis2.26223185
21MP0000609_abnormal_liver_physiology2.07893825
22MP0000566_synostosis2.02299511
23MP0002118_abnormal_lipid_homeostasis1.99393613
24MP0002138_abnormal_hepatobiliary_system1.96999974
25MP0003705_abnormal_hypodermis_morpholog1.94557169
26MP0002254_reproductive_system_inflammat1.94417555
27MP0003878_abnormal_ear_physiology1.90851593
28MP0005377_hearing/vestibular/ear_phenot1.90851593
29MP0003868_abnormal_feces_composition1.78266361
30MP0010352_gastrointestinal_tract_polyps1.76326964
31MP0005319_abnormal_enzyme/_coenzyme1.73047947
32MP0003011_delayed_dark_adaptation1.46372016
33MP0001191_abnormal_skin_condition1.43275054
34MP0005584_abnormal_enzyme/coenzyme_acti1.42200366
35MP0001764_abnormal_homeostasis1.39241561
36MP0005451_abnormal_body_composition1.39052699
37MP0002234_abnormal_pharynx_morphology1.29765047
38MP0008260_abnormal_autophagy1.28983923
39MP0009643_abnormal_urine_homeostasis1.27335395
40* MP0000579_abnormal_nail_morphology1.26186156
41* MP0002796_impaired_skin_barrier1.25134559
42MP0009697_abnormal_copulation1.22058576
43MP0001851_eye_inflammation1.21695310
44MP0010234_abnormal_vibrissa_follicle1.19919770
45MP0001849_ear_inflammation1.10999643
46MP0000598_abnormal_liver_morphology1.10250989
47MP0004272_abnormal_basement_membrane1.10228194
48MP0003186_abnormal_redox_activity1.08341425
49MP0000604_amyloidosis1.07910702
50MP0005647_abnormal_sex_gland1.06478839
51MP0003656_abnormal_erythrocyte_physiolo1.03361605
52MP0004381_abnormal_hair_follicle0.98684645
53MP0009053_abnormal_anal_canal0.98025869
54MP0009764_decreased_sensitivity_to0.97143454
55MP0003315_abnormal_perineum_morphology0.96131207
56MP0000465_gastrointestinal_hemorrhage0.94931407
57MP0002098_abnormal_vibrissa_morphology0.93206856
58MP0003303_peritoneal_inflammation0.93109043
59MP0005408_hypopigmentation0.91942136
60MP0002095_abnormal_skin_pigmentation0.91284173
61MP0005636_abnormal_mineral_homeostasis0.90040163
62MP0009763_increased_sensitivity_to0.89725369
63MP0000678_abnormal_parathyroid_gland0.89098184
64MP0002877_abnormal_melanocyte_morpholog0.88509145
65MP0000647_abnormal_sebaceous_gland0.88127508
66MP0000858_altered_metastatic_potential0.88105745
67MP0010368_abnormal_lymphatic_system0.87780337
68MP0005275_abnormal_skin_tensile0.87028060
69MP0005257_abnormal_intraocular_pressure0.86285718
70MP0003950_abnormal_plasma_membrane0.84194704
71MP0000427_abnormal_hair_cycle0.82695855
72MP0003300_gastrointestinal_ulcer0.82589672
73MP0004043_abnormal_pH_regulation0.82408929
74MP0001661_extended_life_span0.80637624
75MP0004185_abnormal_adipocyte_glucose0.79777270
76MP0008469_abnormal_protein_level0.78990022
77MP0005220_abnormal_exocrine_pancreas0.78858503
78MP0009642_abnormal_blood_homeostasis0.77943920
79MP0010678_abnormal_skin_adnexa0.74895600
80MP0000627_abnormal_mammary_gland0.74841391
81MP0005670_abnormal_white_adipose0.74103751
82MP0000377_abnormal_hair_follicle0.73710177
83MP0002971_abnormal_brown_adipose0.69560862
84MP0008004_abnormal_stomach_pH0.69228855
85MP0000383_abnormal_hair_follicle0.67892448
86* MP0004885_abnormal_endolymph0.67204881
87MP0009765_abnormal_xenobiotic_induced0.66122236
88MP0001243_abnormal_dermal_layer0.65558750
89MP0002078_abnormal_glucose_homeostasis0.65294260
90MP0005376_homeostasis/metabolism_phenot0.63979346
91MP0003329_amyloid_beta_deposits0.63396051
92MP0002876_abnormal_thyroid_physiology0.63383596
93MP0005248_abnormal_Harderian_gland0.63031327
94MP0009384_cardiac_valve_regurgitation0.62319601
95MP0001756_abnormal_urination0.61737704
96MP0004130_abnormal_muscle_cell0.61668002
97MP0002148_abnormal_hypersensitivity_rea0.61646753
98MP0001188_hyperpigmentation0.61492064
99MP0009785_altered_susceptibility_to0.60851370
100MP0005334_abnormal_fat_pad0.60643901
101MP0005084_abnormal_gallbladder_morpholo0.58762525
102MP0006036_abnormal_mitochondrial_physio0.58600495
103MP0000467_abnormal_esophagus_morphology0.58590298
104MP0004947_skin_inflammation0.58091638
105* MP0002060_abnormal_skin_morphology0.56593224
106MP0003690_abnormal_glial_cell0.56546744
107* MP0005501_abnormal_skin_physiology0.56390220
108* MP0001216_abnormal_epidermal_layer0.55732416
109MP0000639_abnormal_adrenal_gland0.55522915
110MP0003448_altered_tumor_morphology0.54808102
111MP0005535_abnormal_body_temperature0.53817880
112* MP0004264_abnormal_extraembryonic_tissu0.53670456
113MP0001881_abnormal_mammary_gland0.53272675
114MP0003638_abnormal_response/metabolism_0.52510801
115* MP0003453_abnormal_keratinocyte_physiol0.52405496
116MP0002136_abnormal_kidney_physiology0.52170699
117MP0005164_abnormal_response_to0.51084724
118MP0010155_abnormal_intestine_physiology0.50532378
119MP0005448_abnormal_energy_balance0.48237366
120MP0001533_abnormal_skeleton_physiology0.47956763
121MP0002006_tumorigenesis0.47913488
122* MP0001784_abnormal_fluid_regulation0.46362881
123MP0000367_abnormal_coat/_hair0.45692321
124MP0005666_abnormal_adipose_tissue0.44760767
125MP0004782_abnormal_surfactant_physiolog0.44746900
126MP0003755_abnormal_palate_morphology0.44589907
127MP0005266_abnormal_metabolism0.44021224
128MP0002282_abnormal_trachea_morphology0.43343049
129MP0003045_fibrosis0.42944156
130MP0005023_abnormal_wound_healing0.42663176
131MP0001340_abnormal_eyelid_morphology0.42473296
132MP0005193_abnormal_anterior_eye0.42405683
133MP0005395_other_phenotype0.41930403
134MP0002177_abnormal_outer_ear0.41877687
135MP0003075_altered_response_to0.40643653
136MP0005464_abnormal_platelet_physiology0.40316296
137MP0002928_abnormal_bile_duct0.39591713
138MP0003091_abnormal_cell_migration0.39125749
139* MP0009931_abnormal_skin_appearance0.37012522
140MP0008789_abnormal_olfactory_epithelium0.36195503
141MP0001790_abnormal_immune_system0.35983317
142MP0005387_immune_system_phenotype0.35983317
143MP0005375_adipose_tissue_phenotype0.35707421
144MP0005197_abnormal_uvea_morphology0.35454924
145MP0000685_abnormal_immune_system0.35448261
146MP0002896_abnormal_bone_mineralization0.35228957
147MP0003436_decreased_susceptibility_to0.35079352
148MP0000537_abnormal_urethra_morphology0.34811915
149MP0008873_increased_physiological_sensi0.34781850
150MP0003828_pulmonary_edema0.34413935
151MP0005166_decreased_susceptibility_to0.34274929
152MP0006082_CNS_inflammation0.33402499
153MP0005025_abnormal_response_to0.32929590
154MP0009672_abnormal_birth_weight0.32854329
155MP0002168_other_aberrant_phenotype0.32808520
156MP0005165_increased_susceptibility_to0.32358380
157MP0002089_abnormal_postnatal_growth/wei0.32329235
158MP0003724_increased_susceptibility_to0.31807119
159MP0008874_decreased_physiological_sensi0.31517904
160MP0002970_abnormal_white_adipose0.31395918
161MP0001765_abnormal_ion_homeostasis0.31384647
162MP0000470_abnormal_stomach_morphology0.31197876
163MP0006054_spinal_hemorrhage0.30556848
164MP0003763_abnormal_thymus_physiology0.30421638

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.86972632
2* Plantar hyperkeratosis (HP:0007556)8.06216363
3* Palmoplantar hyperkeratosis (HP:0000972)7.95087710
4Thick nail (HP:0001805)7.60079310
5* Palmar hyperkeratosis (HP:0010765)7.52457040
6Deep venous thrombosis (HP:0002625)7.36029526
7Intrahepatic cholestasis (HP:0001406)7.18591130
8Abnormality of aromatic amino acid family metabolism (HP:0004338)7.12324019
9Abnormality of monocarboxylic acid metabolism (HP:0010996)6.50179031
10Xanthomatosis (HP:0000991)6.21895250
11Prolonged partial thromboplastin time (HP:0003645)6.20909130
12Hypobetalipoproteinemia (HP:0003563)6.07733597
13Fragile nails (HP:0001808)6.04685905
14Milia (HP:0001056)5.96791323
15Congenital ichthyosiform erythroderma (HP:0007431)5.92089558
16Increased IgE level (HP:0003212)5.88805758
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.53926429
18Hyperlipoproteinemia (HP:0010980)5.44878983
19Complement deficiency (HP:0004431)5.39467801
20Hypotrichosis (HP:0001006)5.30412928
21Abnormality of secondary sexual hair (HP:0009888)5.15989410
22Abnormality of the axillary hair (HP:0100134)5.15989410
23* Alopecia of scalp (HP:0002293)5.12696096
24* Erythroderma (HP:0001019)4.99605056
25* Nail dystrophy (HP:0008404)4.99154359
26Erythema (HP:0010783)4.72608440
27Hypolipoproteinemia (HP:0010981)4.67418101
28Joint hemorrhage (HP:0005261)4.51536499
29Epidermoid cyst (HP:0200040)4.50551907
30Hyperammonemia (HP:0001987)4.50077651
31Abnormality of the common coagulation pathway (HP:0010990)4.46442782
32Parakeratosis (HP:0001036)4.44849741
33Woolly hair (HP:0002224)4.44035791
34Abnormal blistering of the skin (HP:0008066)4.39829213
35* Corneal erosion (HP:0200020)4.37828889
36Abnormality of glutamine family amino acid metabolism (HP:0010902)4.36119790
37Ridged nail (HP:0001807)4.28211781
38Hyperglycinemia (HP:0002154)4.27074940
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26779405
40Pili torti (HP:0003777)4.26439580
41* Oral leukoplakia (HP:0002745)4.24980081
42Hypoalphalipoproteinemia (HP:0003233)4.21450227
43Abnormality of sulfur amino acid metabolism (HP:0004339)4.18371418
44Ketosis (HP:0001946)4.15567945
45Fat malabsorption (HP:0002630)4.07958906
46Ectropion (HP:0000656)4.02078746
47Abnormality of aspartate family amino acid metabolism (HP:0010899)4.01195768
48Abnormality of methionine metabolism (HP:0010901)4.00414755
49Abnormality of complement system (HP:0005339)3.93445900
50Hyperglycinuria (HP:0003108)3.89029967
51Atrophic scars (HP:0001075)3.87415887
52Abnormality of serine family amino acid metabolism (HP:0010894)3.82406285
53Abnormality of glycine metabolism (HP:0010895)3.82406285
54Abnormal hair laboratory examination (HP:0003328)3.76535822
55* Palmoplantar keratoderma (HP:0000982)3.74029938
56Hypoglycemic coma (HP:0001325)3.72501683
57Abnormality of the intrinsic pathway (HP:0010989)3.70580560
58Lip pit (HP:0100267)3.52064838
59Hypercholesterolemia (HP:0003124)3.51732604
60Abnormality of pyrimidine metabolism (HP:0004353)3.49241624
61Sparse scalp hair (HP:0002209)3.47988082
62Conjugated hyperbilirubinemia (HP:0002908)3.47012921
63Gangrene (HP:0100758)3.35304499
64* Sparse eyelashes (HP:0000653)3.33899597
65* Hypohidrosis (HP:0000966)3.27220693
66Abnormality of fatty-acid metabolism (HP:0004359)3.23711448
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19376252
68Abnormality of the salivary glands (HP:0010286)3.16749860
69Hyperbilirubinemia (HP:0002904)3.11704436
70Steatorrhea (HP:0002570)3.09447892
71Follicular hyperkeratosis (HP:0007502)3.08131643
72Abnormality of nucleobase metabolism (HP:0010932)3.06947745
73Hepatocellular carcinoma (HP:0001402)3.05285152
74Myocardial infarction (HP:0001658)2.99495516
75Spontaneous abortion (HP:0005268)2.98143147
76Blepharitis (HP:0000498)2.97197926
77Ketoacidosis (HP:0001993)2.96439545
78Pustule (HP:0200039)2.95194325
79Natal tooth (HP:0000695)2.94270987
80Delayed CNS myelination (HP:0002188)2.93410618
81Abnormality of serum amino acid levels (HP:0003112)2.85841232
82Abnormality of purine metabolism (HP:0004352)2.85800805
83Vascular calcification (HP:0004934)2.81630649
84Selective tooth agenesis (HP:0001592)2.78466701
85Systemic lupus erythematosus (HP:0002725)2.74845095
86Hypochromic microcytic anemia (HP:0004840)2.68853405
87Skin nodule (HP:0200036)2.67501066
88Gout (HP:0001997)2.66262850
89Metabolic acidosis (HP:0001942)2.61114078
90Spastic diplegia (HP:0001264)2.57699436
91Neonatal onset (HP:0003623)2.54089935
92Cardiovascular calcification (HP:0011915)2.53406015
93Anonychia (HP:0001798)2.48673450
94Hyperhidrosis (HP:0000975)2.44238973
95Lethargy (HP:0001254)2.43042206
96Dry hair (HP:0011359)2.42396082
97Dicarboxylic aciduria (HP:0003215)2.42136147
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42136147
99Abnormal gallbladder morphology (HP:0012437)2.41049412
100Conjunctival hamartoma (HP:0100780)2.40734999
101Hypoplastic labia majora (HP:0000059)2.40446812
102Pruritus (HP:0000989)2.40114684
103Cholelithiasis (HP:0001081)2.37971633
104Glomerulonephritis (HP:0000099)2.37426669
105Esophageal varix (HP:0002040)2.37194339
106Malnutrition (HP:0004395)2.36994058
107Advanced eruption of teeth (HP:0006288)2.35894956
108Mitral stenosis (HP:0001718)2.35161704
109Hypoglycemic seizures (HP:0002173)2.34879197
110Amyloidosis (HP:0011034)2.31025399
111Dehydration (HP:0001944)2.30441208
112Acanthocytosis (HP:0001927)2.27234679
113Hypoplasia of dental enamel (HP:0006297)2.25536231
114Irritability (HP:0000737)2.25433813
115Laryngomalacia (HP:0001601)2.22257855
116Gingival bleeding (HP:0000225)2.21797322
117Popliteal pterygium (HP:0009756)2.19969834
118Abnormality of the neuromuscular junction (HP:0003398)2.19830304
119Fatigable weakness (HP:0003473)2.19830304
120Xerostomia (HP:0000217)2.19758652
121Corneal dystrophy (HP:0001131)2.18810099
122Hydroxyprolinuria (HP:0003080)2.18629352
123Abnormality of proline metabolism (HP:0010907)2.18629352
124Abnormality of the labia majora (HP:0012881)2.16481067
125Oligodontia (HP:0000677)2.15414954
126Recurrent gram-negative bacterial infections (HP:0005420)2.14962639
127Cholecystitis (HP:0001082)2.14037913
128Abnormal gallbladder physiology (HP:0012438)2.14037913
129Fragile skin (HP:0001030)2.13299398
130Sensorimotor neuropathy (HP:0007141)2.12432244
131Pterygium (HP:0001059)2.12193232
132* Carious teeth (HP:0000670)2.11779477
133Menorrhagia (HP:0000132)2.11760077
134Brittle hair (HP:0002299)2.10155342
135Pancreatitis (HP:0001733)2.08841875
136Hemorrhage of the eye (HP:0011885)2.08180427
137Cerebral edema (HP:0002181)2.07326304
138Rickets (HP:0002748)2.06685914
139Late onset (HP:0003584)2.06043327
140Thrombophlebitis (HP:0004418)2.05106025
141* Absent hair (HP:0002298)2.04483496
142* Abnormality of nail color (HP:0100643)11.4774986
143Brushfield spots (HP:0001088)1.99168424
144Enlarged kidneys (HP:0000105)1.98515115
145Generalized aminoaciduria (HP:0002909)1.97749947
146Ankyloglossia (HP:0010296)1.97683030
147Right ventricular cardiomyopathy (HP:0011663)1.96364587
148Abnormality of the gallbladder (HP:0005264)1.96002239
149Vomiting (HP:0002013)1.95176201
150Hypophosphatemic rickets (HP:0004912)1.95108357
151Opisthotonus (HP:0002179)1.94068846
152Slow-growing hair (HP:0002217)1.92942052
153Abnormality of hair growth rate (HP:0011363)1.92942052
154* Skin ulcer (HP:0200042)1.91522121
155Abnormal cartilage morphology (HP:0002763)1.91116393
156Abnormality of transition element cation homeostasis (HP:0011030)1.89961017
157* Absent eyelashes (HP:0000561)1.89828601
158Lack of skin elasticity (HP:0100679)1.88831186
159Increased purine levels (HP:0004368)1.87124390
160Hyperuricemia (HP:0002149)1.87124390
161Nephritis (HP:0000123)1.86690181
162Abnormality of iron homeostasis (HP:0011031)1.86643853
163Abnormal enzyme/coenzyme activity (HP:0012379)1.85554419
164* Abnormality of the fingernails (HP:0001231)1.84445860
165Aplasia cutis congenita (HP:0001057)1.84309537
166Alkalosis (HP:0001948)1.82648935
167Hyperinsulinemic hypoglycemia (HP:0000825)1.82259530
168Back pain (HP:0003418)1.80889927
169Axonal loss (HP:0003447)1.78664908
170Poikilocytosis (HP:0004447)1.74659087
171Abnormality of the Achilles tendon (HP:0005109)1.72721498
172Hypergammaglobulinemia (HP:0010702)1.70355764
173Split foot (HP:0001839)1.68941749
174Ventricular tachycardia (HP:0004756)1.66610956
175Dry skin (HP:0000958)1.66074800
176Paralysis (HP:0003470)1.63814881
177Septate vagina (HP:0001153)1.63558317
178Acanthosis nigricans (HP:0000956)1.59755315
179* Multifactorial inheritance (HP:0001426)1.58404087
180Breast hypoplasia (HP:0003187)1.58379772
181Melanocytic nevus (HP:0000995)1.58041476
182Neurofibrillary tangles (HP:0002185)1.54562471
183Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.53730082
184Conical tooth (HP:0000698)1.53485016
185Curly hair (HP:0002212)1.49856553
186* Urticaria (HP:0001025)1.49353271
187* Furrowed tongue (HP:0000221)1.49205925
188Abnormality of permanent molar morphology (HP:0011071)1.48859519
189Abnormality of the dental root (HP:0006486)1.48859519
190Taurodontia (HP:0000679)1.48859519
191Abnormality of the gastric mucosa (HP:0004295)1.48582004
192Abnormality of oral frenula (HP:0000190)1.47811963
193Sepsis (HP:0100806)1.45296806
194Premature loss of primary teeth (HP:0006323)1.43088666
195Nasolacrimal duct obstruction (HP:0000579)1.43063816
196Labial hypoplasia (HP:0000066)1.42790695
197Abnormality of glycolipid metabolism (HP:0010969)1.41656401
198Abnormality of glycosphingolipid metabolism (HP:0004343)1.41656401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.98241949
2ERN14.78705871
3SIK14.43818382
4FGFR44.28238115
5TGFBR13.27056400
6MAP3K92.99466775
7STK242.85117597
8TAOK32.74250231
9LATS12.73411603
10TRIB32.72921560
11PKN22.58174021
12MST1R2.49662653
13ERBB42.48541834
14PIM22.48004031
15ARAF2.36014423
16INSRR2.22085446
17PTK61.95387299
18MAP2K41.89117302
19PIK3CG1.80479925
20DDR21.66750838
21MAPK111.60300220
22EPHB11.58168049
23TYK21.53517489
24NTRK11.51324834
25PRPF4B1.44106070
26FLT31.41453872
27NME21.39957373
28FRK1.39412323
29MST41.32380749
30IKBKB1.31327059
31MAP3K71.30365525
32EPHA31.29834801
33FGFR21.29361433
34STK38L1.28082679
35DAPK21.26342956
36MAP3K31.20012652
37NEK91.19005601
38MET1.15916760
39ABL21.15524560
40MOS1.15166069
41JAK21.14475528
42ERBB21.14257347
43TBK11.06753764
44JAK11.05611090
45RIPK11.02195246
46MAP3K121.01287209
47LMTK21.01227051
48CDK121.00217934
49GRK70.99161760
50MAP3K100.98755034
51PAK40.98527318
52TRPM70.97341726
53PRKAA20.97110099
54CDK60.96539735
55GRK60.95126204
56MAP3K140.94588490
57FGFR30.93895304
58KSR20.93620269
59DYRK1B0.93379391
60FER0.93229779
61FGR0.93034167
62MAP2K30.92162823
63PTK20.90491277
64MATK0.89099823
65CDC42BPA0.85660808
66KDR0.83486183
67TAOK20.82893023
68IRAK30.80725908
69PRKCZ0.80289050
70GSK3A0.77743993
71JAK30.77538466
72MAP3K110.76655114
73MAPK150.75564183
74BLK0.75549214
75BMPR20.74701345
76TESK10.73846170
77STK100.72625983
78MAPK40.71806914
79CAMK1D0.71386090
80EPHA20.71181889
81PBK0.70701270
82BMX0.70127839
83TGFBR20.68990549
84MAP2K60.67941251
85PDGFRB0.66832232
86RET0.63434210
87MAPK120.63234477
88LATS20.61183115
89MAP2K10.59354269
90PDGFRA0.58545948
91CSK0.57752079
92SGK30.57548042
93ERBB30.57456379
94PRKACG0.56334858
95CAMK2G0.56107091
96EPHB20.53110028
97PDPK10.51280937
98PINK10.51147787
99MAPKAPK20.49887347
100SIK30.49662873
101MTOR0.49652115
102PRKAA10.49247195
103FGFR10.48123972
104STK30.46915993
105MAP3K20.46437354
106MAPKAPK30.46426324
107IKBKE0.46269121
108MAP3K10.45382213
109TIE10.45286440
110MAP2K20.44473929
111WNK10.44176421
112BRAF0.42099439
113IGF1R0.40943092
114CHUK0.40770762
115IRAK40.40219339
116CAMK1G0.40061684
117MAPK70.39084645
118IRAK20.37865478
119MAP3K60.37744428
120SMG10.37201886
121PRKD20.35651429
122ZAP700.34731245
123MAP3K50.34689759
124LRRK20.33523914
125EGFR0.33361439
126CSNK1G10.32795442
127KSR10.31813746
128RPS6KA20.30714450
129ROCK20.30641896
130PRKCQ0.30622288
131PAK30.30547051
132RPS6KB10.30175044
133MAP3K130.30135495
134SGK20.29748625
135ICK0.29677403
136PRKCI0.29531115
137NEK60.27151889
138BCR0.26664909
139CSF1R0.25907890
140DMPK0.25849022
141PDK10.25738030
142PIK3CA0.25002527
143STK380.24612966
144SGK2230.23401396
145SGK4940.23401396
146ABL10.22663702
147IRAK10.21495234
148PKN10.21483725
149TAOK10.20765749

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.42816608
2Nitrogen metabolism_Homo sapiens_hsa009103.63107170
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.42898371
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35161877
5Arginine biosynthesis_Homo sapiens_hsa002203.04725670
6Complement and coagulation cascades_Homo sapiens_hsa046102.75495627
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67127512
8Tryptophan metabolism_Homo sapiens_hsa003802.66755052
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57978132
10Fatty acid degradation_Homo sapiens_hsa000712.48821701
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48103944
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36523555
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22090771
14Sphingolipid metabolism_Homo sapiens_hsa006002.20236494
15ECM-receptor interaction_Homo sapiens_hsa045122.11558868
16Butanoate metabolism_Homo sapiens_hsa006502.11223312
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09209251
18Peroxisome_Homo sapiens_hsa041462.06000009
19VEGF signaling pathway_Homo sapiens_hsa043702.04251891
20Histidine metabolism_Homo sapiens_hsa003401.96612468
21Chemical carcinogenesis_Homo sapiens_hsa052041.92981791
22PPAR signaling pathway_Homo sapiens_hsa033201.91913426
23Propanoate metabolism_Homo sapiens_hsa006401.91578298
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.90000523
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89427871
26Caffeine metabolism_Homo sapiens_hsa002321.83582856
27Fatty acid metabolism_Homo sapiens_hsa012121.81985216
28Pertussis_Homo sapiens_hsa051331.77820691
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77129206
30Staphylococcus aureus infection_Homo sapiens_hsa051501.73710703
31beta-Alanine metabolism_Homo sapiens_hsa004101.72463081
32Retinol metabolism_Homo sapiens_hsa008301.70322555
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66644417
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.64670698
35Phenylalanine metabolism_Homo sapiens_hsa003601.63122395
36GnRH signaling pathway_Homo sapiens_hsa049121.61326947
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58183660
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54269288
39Selenocompound metabolism_Homo sapiens_hsa004501.53814480
40Bile secretion_Homo sapiens_hsa049761.52122629
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49861283
42Tyrosine metabolism_Homo sapiens_hsa003501.47581655
43Salmonella infection_Homo sapiens_hsa051321.43816412
44Malaria_Homo sapiens_hsa051441.43679888
45Toxoplasmosis_Homo sapiens_hsa051451.42099897
46Small cell lung cancer_Homo sapiens_hsa052221.41906931
47TNF signaling pathway_Homo sapiens_hsa046681.40573462
48Fatty acid elongation_Homo sapiens_hsa000621.35814181
49Pyruvate metabolism_Homo sapiens_hsa006201.33844546
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32731394
51Sulfur metabolism_Homo sapiens_hsa009201.32095672
52Fat digestion and absorption_Homo sapiens_hsa049751.31023897
53Starch and sucrose metabolism_Homo sapiens_hsa005001.27627231
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.23845189
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22554882
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20556578
57Steroid biosynthesis_Homo sapiens_hsa001001.19484255
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19454692
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19121294
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18318912
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16514982
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14999520
63Biosynthesis of amino acids_Homo sapiens_hsa012301.14614471
64Folate biosynthesis_Homo sapiens_hsa007901.14224501
65ABC transporters_Homo sapiens_hsa020101.13824962
66Tuberculosis_Homo sapiens_hsa051521.13657823
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.09954500
68p53 signaling pathway_Homo sapiens_hsa041151.08163439
69Acute myeloid leukemia_Homo sapiens_hsa052211.07899475
70Adherens junction_Homo sapiens_hsa045201.07673999
71Carbon metabolism_Homo sapiens_hsa012001.07023680
72Influenza A_Homo sapiens_hsa051641.04750275
73Shigellosis_Homo sapiens_hsa051311.04600662
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03974158
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02140820
76Lysosome_Homo sapiens_hsa041420.99917581
77Proteoglycans in cancer_Homo sapiens_hsa052050.99760108
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.98908809
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98198097
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97460197
81Arginine and proline metabolism_Homo sapiens_hsa003300.97439925
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.95500833
83Vitamin digestion and absorption_Homo sapiens_hsa049770.95121826
84Focal adhesion_Homo sapiens_hsa045100.94896996
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93998413
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93581353
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89963241
88ErbB signaling pathway_Homo sapiens_hsa040120.89588797
89Leishmaniasis_Homo sapiens_hsa051400.88785139
90Sulfur relay system_Homo sapiens_hsa041220.88540816
91Lysine degradation_Homo sapiens_hsa003100.85813249
92Other glycan degradation_Homo sapiens_hsa005110.84951665
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84289915
94MicroRNAs in cancer_Homo sapiens_hsa052060.83687584
95Rheumatoid arthritis_Homo sapiens_hsa053230.83305048
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82036550
97Long-term depression_Homo sapiens_hsa047300.80906945
98Legionellosis_Homo sapiens_hsa051340.78326024
99Glioma_Homo sapiens_hsa052140.78199901
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.76930929
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76650425
102Dorso-ventral axis formation_Homo sapiens_hsa043200.75999754
103Vitamin B6 metabolism_Homo sapiens_hsa007500.75091827
104Renal cell carcinoma_Homo sapiens_hsa052110.74683600
105Osteoclast differentiation_Homo sapiens_hsa043800.73068001
106Thyroid cancer_Homo sapiens_hsa052160.72528332
107Glycerolipid metabolism_Homo sapiens_hsa005610.72024009
108Pancreatic cancer_Homo sapiens_hsa052120.71794100
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71622562
110Renin secretion_Homo sapiens_hsa049240.71394693
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69763943
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67737227
113Notch signaling pathway_Homo sapiens_hsa043300.66831821
114Choline metabolism in cancer_Homo sapiens_hsa052310.65613137
115Chronic myeloid leukemia_Homo sapiens_hsa052200.65006503
116Glutathione metabolism_Homo sapiens_hsa004800.64826331
117Fatty acid biosynthesis_Homo sapiens_hsa000610.64444905
118Apoptosis_Homo sapiens_hsa042100.59403031
119Hematopoietic cell lineage_Homo sapiens_hsa046400.58894180
120One carbon pool by folate_Homo sapiens_hsa006700.58484456
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.58262511
122Endocytosis_Homo sapiens_hsa041440.56264688
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.54074433
124Pentose phosphate pathway_Homo sapiens_hsa000300.52536872
125Ras signaling pathway_Homo sapiens_hsa040140.51762892
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51238786
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48512740
128Phagosome_Homo sapiens_hsa041450.48038455
129Pathways in cancer_Homo sapiens_hsa052000.46941057
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.46868602
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46714723
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.46281978
133Axon guidance_Homo sapiens_hsa043600.45902306
134Platelet activation_Homo sapiens_hsa046110.45770116
135Graft-versus-host disease_Homo sapiens_hsa053320.42640426
136HIF-1 signaling pathway_Homo sapiens_hsa040660.42482048
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41416960
138Linoleic acid metabolism_Homo sapiens_hsa005910.40715241
139Metabolic pathways_Homo sapiens_hsa011000.40586667
140Serotonergic synapse_Homo sapiens_hsa047260.39954672
141Prion diseases_Homo sapiens_hsa050200.34857655
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31784054
143Insulin resistance_Homo sapiens_hsa049310.30339867
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.27629630
145Galactose metabolism_Homo sapiens_hsa000520.23703021
146Fructose and mannose metabolism_Homo sapiens_hsa000510.18663379
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.17325160
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11427014
149Glucagon signaling pathway_Homo sapiens_hsa049220.08500055
150AMPK signaling pathway_Homo sapiens_hsa041520.04349502
151Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2122494
152Mineral absorption_Homo sapiens_hsa04978-0.1999282
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1957308
154Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1833834
155African trypanosomiasis_Homo sapiens_hsa05143-0.1828992
156Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1623364
157Renin-angiotensin system_Homo sapiens_hsa04614-0.1494880
158Ether lipid metabolism_Homo sapiens_hsa00565-0.1473459
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1338084
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1266606
161Bladder cancer_Homo sapiens_hsa05219-0.1133629
162Amoebiasis_Homo sapiens_hsa05146-0.1032084
163Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1032080
164Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1001332
165Hepatitis C_Homo sapiens_hsa05160-0.0968000
166Insulin signaling pathway_Homo sapiens_hsa04910-0.0801017
167Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0750960
168Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0694674
169Protein digestion and absorption_Homo sapiens_hsa04974-0.0616037
170Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0455058
171Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0167389

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