GJB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.65389228
2bundle of His cell to Purkinje myocyte communication (GO:0086069)9.45661101
3keratinocyte proliferation (GO:0043616)9.33240984
4cell-substrate junction assembly (GO:0007044)7.28154884
5negative regulation of keratinocyte proliferation (GO:0010839)7.16605121
6hair cycle (GO:0042633)6.89296801
7molting cycle (GO:0042303)6.89296801
8keratinocyte differentiation (GO:0030216)6.57576814
9multicellular organismal water homeostasis (GO:0050891)6.28882480
10intermediate filament organization (GO:0045109)6.17160759
11epidermis development (GO:0008544)5.95519747
12formation of translation preinitiation complex (GO:0001731)5.38510480
13regulation of keratinocyte proliferation (GO:0010837)5.34276467
14positive regulation of epidermal cell differentiation (GO:0045606)5.34153929
15positive regulation of epidermis development (GO:0045684)5.25097751
16epidermal cell differentiation (GO:0009913)5.14564095
17water homeostasis (GO:0030104)5.13193696
18surfactant homeostasis (GO:0043129)4.96095538
19regulation of hair follicle development (GO:0051797)4.85936756
20peptide cross-linking (GO:0018149)4.75683575
21interferon-gamma secretion (GO:0072643)4.75293049
22gap junction assembly (GO:0016264)4.70530348
23maturation of SSU-rRNA (GO:0030490)4.55568598
24positive regulation of hair cycle (GO:0042635)4.38097857
25positive regulation of hair follicle development (GO:0051798)4.38097857
26establishment of planar polarity (GO:0001736)4.35335441
27establishment of tissue polarity (GO:0007164)4.35335441
28intestinal epithelial cell development (GO:0060576)4.34373486
29skin morphogenesis (GO:0043589)4.34326046
30ribosome assembly (GO:0042255)4.23887354
31regulation of transforming growth factor beta2 production (GO:0032909)4.17680139
32ribosomal small subunit biogenesis (GO:0042274)4.16352628
33regulation of gene silencing by RNA (GO:0060966)4.13950703
34regulation of posttranscriptional gene silencing (GO:0060147)4.13950703
35regulation of gene silencing by miRNA (GO:0060964)4.13950703
36positive regulation of keratinocyte differentiation (GO:0045618)4.13714475
37nucleobase biosynthetic process (GO:0046112)4.07002619
38polarized epithelial cell differentiation (GO:0030859)4.06370427
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.06199733
40protein localization to kinetochore (GO:0034501)4.05653010
41chemical homeostasis within a tissue (GO:0048875)4.05057307
42purine nucleobase biosynthetic process (GO:0009113)4.01416408
43ribosome biogenesis (GO:0042254)3.97939332
44regulation of epidermis development (GO:0045682)3.95166309
45epithelial cell differentiation involved in prostate gland development (GO:0060742)3.94247619
46cell adhesion mediated by integrin (GO:0033627)3.93004428
47ribonucleoprotein complex biogenesis (GO:0022613)3.92113354
48ribosomal large subunit biogenesis (GO:0042273)3.91995104
49hypotonic response (GO:0006971)3.91678774
50intermediate filament cytoskeleton organization (GO:0045104)3.86343706
51folic acid metabolic process (GO:0046655)3.86168360
52regulation of hair cycle (GO:0042634)3.81901678
53trophectodermal cell differentiation (GO:0001829)3.77560511
54ectoderm development (GO:0007398)3.75983941
55DNA replication-dependent nucleosome organization (GO:0034723)3.75438735
56DNA replication-dependent nucleosome assembly (GO:0006335)3.75438735
57protein localization to endosome (GO:0036010)3.73501116
58establishment of skin barrier (GO:0061436)3.72665355
59DNA replication checkpoint (GO:0000076)3.72154379
60negative regulation of chondrocyte differentiation (GO:0032331)3.71511700
61intermediate filament-based process (GO:0045103)3.71054146
62regulation of keratinocyte differentiation (GO:0045616)3.70825618
63viral transcription (GO:0019083)3.70349515
64activation of Rac GTPase activity (GO:0032863)3.70187073
65regulation of water loss via skin (GO:0033561)3.68883471
66mesodermal cell differentiation (GO:0048333)3.66640636
67translational initiation (GO:0006413)3.66136030
68translational termination (GO:0006415)3.65422772
69rRNA modification (GO:0000154)3.64980201
70DNA replication initiation (GO:0006270)3.64734626
71mitotic metaphase plate congression (GO:0007080)3.63323642
72mitotic nuclear envelope disassembly (GO:0007077)3.59242640
73proteasome assembly (GO:0043248)3.50035917
74regulation of translation in response to stress (GO:0043555)3.49330364
75desmosome organization (GO:0002934)3.47906109
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.47183028
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.42269877
78epithelial cell-cell adhesion (GO:0090136)3.38068260
79negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.36908764
80nuclear envelope disassembly (GO:0051081)3.36223888
81membrane disassembly (GO:0030397)3.36223888
82lateral sprouting from an epithelium (GO:0060601)3.34949554
83translational elongation (GO:0006414)3.34761758
84DNA strand elongation involved in DNA replication (GO:0006271)3.34661977
85mitotic sister chromatid segregation (GO:0000070)3.34577537
86histone H4-K12 acetylation (GO:0043983)3.32467994
87regulation of epidermal cell differentiation (GO:0045604)3.31995262
88cell junction assembly (GO:0034329)3.31888089
89regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.30078456
90morphogenesis of embryonic epithelium (GO:0016331)3.28476135
91ventricular cardiac muscle cell action potential (GO:0086005)3.27788610
92DNA deamination (GO:0045006)3.27751022
93pseudouridine synthesis (GO:0001522)3.26876835
94atrioventricular valve morphogenesis (GO:0003181)3.26083857
95rRNA processing (GO:0006364)3.25238105
96protein localization to chromosome, centromeric region (GO:0071459)3.25038599
97ribosomal small subunit assembly (GO:0000028)3.23286346
98nuclear pore organization (GO:0006999)3.22631090
99negative regulation of cell fate specification (GO:0009996)3.21682606
100cell junction organization (GO:0034330)3.21607541
101somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19825692
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.19825692
103heterochromatin organization (GO:0070828)3.19771516
104focal adhesion assembly (GO:0048041)3.19060110
105cell-substrate adherens junction assembly (GO:0007045)3.19060110
106DNA unwinding involved in DNA replication (GO:0006268)3.18775070
107nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18416572
108DNA strand elongation (GO:0022616)3.14304986
109rRNA metabolic process (GO:0016072)3.14194595
110mammary gland epithelial cell proliferation (GO:0033598)3.13925932
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13239690
112negative regulation of epidermis development (GO:0045683)3.11026753
113regulation of telomere maintenance via telomerase (GO:0032210)3.10163260
114planar cell polarity pathway involved in neural tube closure (GO:0090179)3.08985797
115anterior/posterior axis specification, embryo (GO:0008595)3.08117305
116negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.07614870
117folic acid-containing compound biosynthetic process (GO:0009396)3.06918663
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04200325
119keratinocyte development (GO:0003334)3.03093957
120determination of adult lifespan (GO:0008340)3.02206741
121positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00945710
122blastocyst development (GO:0001824)2.98574025
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97121569
124nuclear pore complex assembly (GO:0051292)2.94712602
125epithelium development (GO:0060429)2.93783276
126metaphase plate congression (GO:0051310)2.93000868
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92127142
128establishment of protein localization to mitochondrial membrane (GO:0090151)2.91346118
129viral life cycle (GO:0019058)2.90662581
130cellular protein complex disassembly (GO:0043624)2.90661847
131translation (GO:0006412)2.89938571
132telomere maintenance via semi-conservative replication (GO:0032201)2.88787249
133rRNA methylation (GO:0031167)2.88634633
134negative regulation of translational initiation (GO:0045947)2.87331963
135membrane raft organization (GO:0031579)2.86029665
136signal transduction involved in DNA damage checkpoint (GO:0072422)2.85741484
137signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85741484
138GDP-mannose metabolic process (GO:0019673)2.85013017
139IMP biosynthetic process (GO:0006188)2.84611302
140DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84237080
141cullin deneddylation (GO:0010388)2.84023365
142regulation of cardioblast differentiation (GO:0051890)2.83566946
143protein targeting to ER (GO:0045047)2.83340366
144folic acid transport (GO:0015884)2.82959159
145L-serine transport (GO:0015825)2.82768810
146negative regulation of ligase activity (GO:0051352)2.82730130
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82730130
148cotranslational protein targeting to membrane (GO:0006613)2.82554227
149protein localization to microtubule (GO:0035372)2.81221682
150COPI coating of Golgi vesicle (GO:0048205)2.80632823
151Golgi transport vesicle coating (GO:0048200)2.80632823
152signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80252029
153signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80252029
154signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80252029
155signal transduction involved in cell cycle checkpoint (GO:0072395)2.79937527
156signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78876885
157intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78876885
158nuclear envelope organization (GO:0006998)2.78594194
159histone arginine methylation (GO:0034969)2.77952282
160regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77809065
161positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76130582
162positive regulation of chromosome segregation (GO:0051984)2.75770402
163positive regulation of SMAD protein import into nucleus (GO:0060391)2.75438913
164regulation of phospholipase A2 activity (GO:0032429)2.75188513
165cell differentiation involved in embryonic placenta development (GO:0060706)2.74657517
166adherens junction assembly (GO:0034333)2.74471120
167cellular component biogenesis (GO:0044085)2.74295212
168endodermal cell differentiation (GO:0035987)2.74246258
169regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.73919991
170DNA geometric change (GO:0032392)2.73395173
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.73174189
172DNA duplex unwinding (GO:0032508)2.72747920
173sister chromatid segregation (GO:0000819)2.72435559
174plasma membrane repair (GO:0001778)2.71932493
175regulation of translational termination (GO:0006449)2.71718164
176negative regulation of stem cell proliferation (GO:2000647)2.69220233
177branching involved in mammary gland duct morphogenesis (GO:0060444)2.68508709
178regulation of metalloenzyme activity (GO:0048552)2.66421811
179long-chain fatty acid biosynthetic process (GO:0042759)2.65701839
180renal system development (GO:0072001)2.64531530
181adherens junction organization (GO:0034332)2.62558620
182negative regulation of cartilage development (GO:0061037)2.61967868
183hair follicle morphogenesis (GO:0031069)2.55214588
184cell-cell junction assembly (GO:0007043)2.53744537
185G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.53590397
186endosome organization (GO:0007032)2.53466906
187regulation of heart rate by cardiac conduction (GO:0086091)2.53145749
188renal filtration (GO:0097205)2.52686497
189gland morphogenesis (GO:0022612)2.51208168
190wound healing (GO:0042060)2.50791723
191membrane tubulation (GO:0097320)2.50643307
192epithelial cell proliferation (GO:0050673)2.50578178
193cell communication involved in cardiac conduction (GO:0086065)2.49160364
194cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.48974242
195hemidesmosome assembly (GO:0031581)17.9166898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.38135145
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.77055645
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.96874613
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.86853226
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15814090
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.07489783
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.07489783
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.07489783
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.05741410
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.05741410
11P63_26484246_Chip-Seq_KERATINOCYTES_Human3.02224109
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01737737
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.83275726
14* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.63972613
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61097188
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.59273957
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58398598
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51945733
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49707288
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41241026
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38029534
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.37950962
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34076219
24* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.33596369
25* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.29754835
26* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.28139102
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27243157
28* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.24719057
29CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24162802
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.23269260
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17556183
32* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16779254
33* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.10055190
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.09738724
35* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09233593
36* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.07331467
37GABP_17652178_ChIP-ChIP_JURKAT_Human2.02106434
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02100576
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97435436
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.96019310
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.94402596
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91755751
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86956950
44XRN2_22483619_ChIP-Seq_HELA_Human1.86550293
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86107840
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81526903
47RACK7_27058665_Chip-Seq_MCF-7_Human1.78334746
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77800050
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75306095
50* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74987459
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.70644801
52* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.70594640
53* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70354681
54* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69689818
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.65004401
56* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.63850232
57AR_21909140_ChIP-Seq_LNCAP_Human1.62336857
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.61045907
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.60759396
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55273639
61ZNF263_19887448_ChIP-Seq_K562_Human1.53991989
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53474382
63* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.53208410
64* SOX2_20726797_ChIP-Seq_SW620_Human1.52024195
65DCP1A_22483619_ChIP-Seq_HELA_Human1.51221432
66VDR_23849224_ChIP-Seq_CD4+_Human1.50310691
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48405931
68* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48405217
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47954694
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46717078
71* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46369278
72* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.45518586
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45284228
74* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.45195097
75TP63_22573176_ChIP-Seq_HFKS_Human1.44911884
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42789630
77TTF2_22483619_ChIP-Seq_HELA_Human1.41609219
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41119084
79TP63_23658742_ChIP-Seq_EP156T_Human1.39650878
80KLF5_25053715_ChIP-Seq_YYC3_Human1.37941901
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.37743091
82GABP_19822575_ChIP-Seq_HepG2_Human1.37077300
83* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36871387
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36484575
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36101420
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34065292
87* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34053492
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.33189576
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32644320
90CLOCK_20551151_ChIP-Seq_293T_Human1.31165419
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30852570
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30705925
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29894015
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27640241
95* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.25069434
96FOXP3_21729870_ChIP-Seq_TREG_Human1.23822566
97GATA6_25053715_ChIP-Seq_YYC3_Human1.23458861
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22296663
99KDM5A_27292631_Chip-Seq_BREAST_Human1.22184029
100* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.20890604
101* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.19558149
102LXR_22292898_ChIP-Seq_THP-1_Human1.19474186
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.18875802
104* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18212609
105POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17561142
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.15154244
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15143350
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.15033027
109* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14477828
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14082999
111TRIM28_21343339_ChIP-Seq_HEK293_Human1.13743763
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13391872
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12476387
114* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09484554
115EGR1_19374776_ChIP-ChIP_THP-1_Human1.07880845
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07498512
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06804863
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.06695375
119ELK1_22589737_ChIP-Seq_MCF10A_Human1.06446486
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05966741
121SALL1_21062744_ChIP-ChIP_HESCs_Human1.04994602
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04987671
123CDX2_20551321_ChIP-Seq_CACO-2_Human1.04767372
124* ATF3_27146783_Chip-Seq_COLON_Human1.04711115
125TFEB_21752829_ChIP-Seq_HELA_Human1.04343698
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04300438
127HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01865506
128GATA3_24758297_ChIP-Seq_MCF-7_Human1.00908495
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99676733
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99659336
131* KAP1_27257070_Chip-Seq_ESCs_Mouse0.99247827
132MYC_22102868_ChIP-Seq_BL_Human0.98323775
133* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97768680
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96731021
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95196121
136YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94781627
137ELK1_19687146_ChIP-ChIP_HELA_Human0.94211448
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93801278
139GATA4_25053715_ChIP-Seq_YYC3_Human0.93540730
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92019319
141* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91656050
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91627539
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91561765
144TP53_22127205_ChIP-Seq_IMR90_Human0.91480135
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90875081
146GATA2_21666600_ChIP-Seq_HMVEC_Human0.90611779
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.90443723
148CJUN_26792858_Chip-Seq_BT549_Human0.90318521
149PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90139902
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89195401
151CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89104366
152* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88971581
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87943813
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.87885315
155ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87609457
156TCF4_18268006_ChIP-ChIP_LS174T_Human0.86432592
157KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86160729
158SMC4_20622854_ChIP-Seq_HELA_Human0.80970754
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76248903
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75810946
161CHD1_26751641_Chip-Seq_LNCaP_Human0.74016733
162KDM2B_26808549_Chip-Seq_K562_Human0.73709693
163CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.71570346
164TBX20_22328084_ChIP-Seq_HEART_Mouse0.71420352
165TBX20_22080862_ChIP-Seq_HEART_Mouse0.71420352
166TP53_18474530_ChIP-ChIP_U2OS_Human0.71231172
167* TET1_21490601_ChIP-Seq_MESCs_Mouse0.70761241
168GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69904793
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.69724651
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69278967
171* CTCF_27219007_Chip-Seq_Bcells_Human0.67973556
172TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64671332
173CREB1_26743006_Chip-Seq_LNCaP_Human0.63184076
174NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63064785
175FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.62975258
176TCF7_22412390_ChIP-Seq_EML_Mouse0.62764827
177PPARA_22158963_ChIP-Seq_LIVER_Mouse0.62311958
178P68_20966046_ChIP-Seq_HELA_Human0.62122375
179ESR1_20079471_ChIP-ChIP_T-47D_Human0.59552510
180CTCF_27219007_Chip-Seq_ERYTHROID_Human0.58340612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.46164175
2MP0004957_abnormal_blastocyst_morpholog4.26522939
3MP0010352_gastrointestinal_tract_polyps3.73663031
4MP0003111_abnormal_nucleus_morphology3.50204847
5MP0000566_synostosis3.35906226
6MP0002796_impaired_skin_barrier3.10195655
7MP0003941_abnormal_skin_development2.91373983
8MP0008057_abnormal_DNA_replication2.89155427
9MP0010234_abnormal_vibrissa_follicle2.87458244
10MP0003077_abnormal_cell_cycle2.78276220
11MP0003705_abnormal_hypodermis_morpholog2.72605356
12MP0010094_abnormal_chromosome_stability2.71739722
13MP0005409_darkened_coat_color2.43166490
14MP0004264_abnormal_extraembryonic_tissu2.39301957
15MP0002234_abnormal_pharynx_morphology2.35756522
16MP0003806_abnormal_nucleotide_metabolis2.30544046
17MP0005501_abnormal_skin_physiology2.24677124
18MP0008932_abnormal_embryonic_tissue2.20958054
19MP0001730_embryonic_growth_arrest2.02110459
20MP0003566_abnormal_cell_adhesion1.97849073
21MP0010030_abnormal_orbit_morphology1.90251161
22MP0000350_abnormal_cell_proliferation1.87545008
23MP0008058_abnormal_DNA_repair1.83174363
24MP0003718_maternal_effect1.81813453
25MP0001672_abnormal_embryogenesis/_devel1.78769002
26MP0005380_embryogenesis_phenotype1.78769002
27MP0004947_skin_inflammation1.76427097
28MP0003315_abnormal_perineum_morphology1.68441687
29MP0003786_premature_aging1.67859170
30MP0004272_abnormal_basement_membrane1.66742433
31MP0002653_abnormal_ependyma_morphology1.65045112
32MP0003453_abnormal_keratinocyte_physiol1.63392533
33MP0005275_abnormal_skin_tensile1.61262012
34MP0008007_abnormal_cellular_replicative1.59392928
35* MP0002086_abnormal_extraembryonic_tissu1.59263054
36MP0002084_abnormal_developmental_patter1.55027412
37MP0003984_embryonic_growth_retardation1.54961376
38MP0002088_abnormal_embryonic_growth/wei1.53811388
39MP0002085_abnormal_embryonic_tissue1.53463982
40MP0001697_abnormal_embryo_size1.52399131
41MP0000678_abnormal_parathyroid_gland1.51331477
42MP0003191_abnormal_cellular_cholesterol1.47054669
43MP0004133_heterotaxia1.46240553
44MP0009379_abnormal_foot_pigmentation1.44121830
45MP0004197_abnormal_fetal_growth/weight/1.43465910
46MP0003123_paternal_imprinting1.43018564
47MP0000762_abnormal_tongue_morphology1.41635319
48* MP0001216_abnormal_epidermal_layer1.40130449
49MP0002254_reproductive_system_inflammat1.39373210
50MP0002098_abnormal_vibrissa_morphology1.38888978
51MP0003890_abnormal_embryonic-extraembry1.38874266
52MP0000490_abnormal_crypts_of1.38341777
53MP0003119_abnormal_digestive_system1.38200756
54* MP0002080_prenatal_lethality1.37322370
55MP0008260_abnormal_autophagy1.34841682
56MP0000427_abnormal_hair_cycle1.34321953
57MP0010678_abnormal_skin_adnexa1.28562391
58MP0000377_abnormal_hair_follicle1.25012812
59MP0002060_abnormal_skin_morphology1.24379464
60MP0000383_abnormal_hair_follicle1.24233112
61MP0001849_ear_inflammation1.23229227
62MP0000537_abnormal_urethra_morphology1.22754484
63MP0000647_abnormal_sebaceous_gland1.22455293
64MP0004782_abnormal_surfactant_physiolog1.21556091
65* MP0005023_abnormal_wound_healing1.20328828
66MP0000467_abnormal_esophagus_morphology1.19482613
67MP0003567_abnormal_fetal_cardiomyocyte1.18449086
68MP0009053_abnormal_anal_canal1.12878718
69MP0001191_abnormal_skin_condition1.12691632
70MP0005075_abnormal_melanosome_morpholog1.11246586
71MP0005367_renal/urinary_system_phenotyp1.10111112
72MP0000516_abnormal_urinary_system1.10111112
73MP0005076_abnormal_cell_differentiation1.09417491
74MP0001293_anophthalmia1.08391653
75MP0002111_abnormal_tail_morphology1.08111918
76MP0009840_abnormal_foam_cell1.06563549
77MP0000579_abnormal_nail_morphology1.05256077
78MP0004381_abnormal_hair_follicle1.00392295
79MP0003950_abnormal_plasma_membrane1.00386363
80MP0003136_yellow_coat_color0.99087840
81MP0006035_abnormal_mitochondrial_morpho0.96607984
82MP0009780_abnormal_chondrocyte_physiolo0.95912252
83MP0000358_abnormal_cell_content/0.95546114
84MP0003186_abnormal_redox_activity0.95223205
85MP0002019_abnormal_tumor_incidence0.94692981
86MP0010771_integument_phenotype0.94265949
87MP0000313_abnormal_cell_death0.92342320
88MP0010307_abnormal_tumor_latency0.89629851
89MP0000858_altered_metastatic_potential0.89459693
90MP0001851_eye_inflammation0.88457141
91MP0000627_abnormal_mammary_gland0.87163254
92MP0005451_abnormal_body_composition0.85253927
93MP0006292_abnormal_olfactory_placode0.84408728
94MP0000750_abnormal_muscle_regeneration0.84239419
95MP0005257_abnormal_intraocular_pressure0.84211909
96MP0003755_abnormal_palate_morphology0.83852545
97MP0003011_delayed_dark_adaptation0.83664148
98MP0005394_taste/olfaction_phenotype0.81803975
99MP0005499_abnormal_olfactory_system0.81803975
100MP0003937_abnormal_limbs/digits/tail_de0.79335895
101MP0004185_abnormal_adipocyte_glucose0.79028205
102MP0005360_urolithiasis0.78701704
103MP0000477_abnormal_intestine_morphology0.78170697
104MP0003283_abnormal_digestive_organ0.77462234
105MP0003936_abnormal_reproductive_system0.75589481
106MP0005266_abnormal_metabolism0.75221096
107MP0001145_abnormal_male_reproductive0.74542091
108MP0002396_abnormal_hematopoietic_system0.74111869
109MP0001340_abnormal_eyelid_morphology0.73988955
110MP0009931_abnormal_skin_appearance0.73588655
111MP0005395_other_phenotype0.72139760
112MP0002877_abnormal_melanocyte_morpholog0.71652400
113MP0002282_abnormal_trachea_morphology0.71619224
114MP0002177_abnormal_outer_ear0.70824671
115MP0005384_cellular_phenotype0.69341457
116MP0005621_abnormal_cell_physiology0.69278857
117MP0000432_abnormal_head_morphology0.68730397
118MP0002277_abnormal_respiratory_mucosa0.68270468
119MP0001243_abnormal_dermal_layer0.68067459
120MP0000367_abnormal_coat/_hair0.66922061
121MP0002092_abnormal_eye_morphology0.66711434
122MP0000003_abnormal_adipose_tissue0.66423129
123MP0008789_abnormal_olfactory_epithelium0.64332225
124MP0004019_abnormal_vitamin_homeostasis0.57962844
125MP0002095_abnormal_skin_pigmentation0.55461745
126MP0003091_abnormal_cell_migration0.55393673
127MP0002089_abnormal_postnatal_growth/wei0.53251035
128MP0005375_adipose_tissue_phenotype0.50353136
129MP0004885_abnormal_endolymph0.48621378
130MP0002896_abnormal_bone_mineralization0.48589829
131MP0005248_abnormal_Harderian_gland0.48448722
132MP0005197_abnormal_uvea_morphology0.47516599
133MP0005193_abnormal_anterior_eye0.46948155
134MP0002697_abnormal_eye_size0.42932129
135MP0005083_abnormal_biliary_tract0.41505859
136MP0003045_fibrosis0.41309493
137MP0005666_abnormal_adipose_tissue0.40379529
138MP0000462_abnormal_digestive_system0.40141412
139MP0004858_abnormal_nervous_system0.39392852
140MP0002006_tumorigenesis0.38469086
141MP0000733_abnormal_muscle_development0.38142034
142MP0000470_abnormal_stomach_morphology0.37599998
143MP0001784_abnormal_fluid_regulation0.37405725
144MP0001299_abnormal_eye_distance/0.37397211
145MP0003638_abnormal_response/metabolism_0.35024955
146MP0005164_abnormal_response_to0.33883696
147MP0001661_extended_life_span0.33164683
148MP0002233_abnormal_nose_morphology0.31002860
149MP0001765_abnormal_ion_homeostasis0.31002101
150MP0001881_abnormal_mammary_gland0.30906533
151MP0000538_abnormal_urinary_bladder0.30627036

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)8.56229835
2Onycholysis (HP:0001806)8.32486876
3Thick nail (HP:0001805)7.17048719
4Palmoplantar hyperkeratosis (HP:0000972)6.83403316
5Palmar hyperkeratosis (HP:0010765)6.46524274
6Atrophic scars (HP:0001075)5.79799664
7Ridged nail (HP:0001807)5.01276240
8* Abnormal blistering of the skin (HP:0008066)4.38264881
9Abnormal hair laboratory examination (HP:0003328)4.32184651
10Breast hypoplasia (HP:0003187)4.18212233
11Ependymoma (HP:0002888)3.80749533
12Trismus (HP:0000211)3.79952513
13Multiple enchondromatosis (HP:0005701)3.70322091
14Sparse scalp hair (HP:0002209)3.54608449
15Pterygium (HP:0001059)3.53119422
16Hypoplasia of dental enamel (HP:0006297)3.46979802
17Natal tooth (HP:0000695)3.44161182
18Premature ovarian failure (HP:0008209)3.38881012
19Selective tooth agenesis (HP:0001592)3.33675183
20Sparse eyelashes (HP:0000653)3.31299084
21Absent radius (HP:0003974)3.30907885
22Rough bone trabeculation (HP:0100670)3.29174547
23Fragile skin (HP:0001030)3.20314710
24Aplasia/hypoplasia of the humerus (HP:0006507)3.13428928
25Popliteal pterygium (HP:0009756)3.13395748
26Dry hair (HP:0011359)3.12513166
27Reticulocytopenia (HP:0001896)3.12088108
28Absent forearm bone (HP:0003953)3.09702154
29Aplasia involving forearm bones (HP:0009822)3.09702154
30Birth length less than 3rd percentile (HP:0003561)3.08040440
31Corneal erosion (HP:0200020)3.04445597
32Erythroderma (HP:0001019)3.03207445
33Oral leukoplakia (HP:0002745)3.02739116
34Abnormality of secondary sexual hair (HP:0009888)2.99110134
35Abnormality of the axillary hair (HP:0100134)2.99110134
36Abnormality of cells of the erythroid lineage (HP:0012130)2.97076115
37Abnormality of placental membranes (HP:0011409)2.92860648
38Amniotic constriction ring (HP:0009775)2.92860648
39Absent eyelashes (HP:0000561)2.92755599
40Carpal bone hypoplasia (HP:0001498)2.91788135
41Cerebral hypomyelination (HP:0006808)2.89684613
42Ankyloglossia (HP:0010296)2.89013820
43Abnormality of the salivary glands (HP:0010286)2.88535425
44Hypoplastic labia majora (HP:0000059)2.85156877
45Rib fusion (HP:0000902)2.83531376
46* Erythema (HP:0010783)2.82268176
47Advanced eruption of teeth (HP:0006288)2.81391987
48* Palmoplantar keratoderma (HP:0000982)2.76061424
49Aplasia cutis congenita (HP:0001057)2.72746431
50Fatigable weakness (HP:0003473)2.72609860
51Abnormality of the neuromuscular junction (HP:0003398)2.72609860
52Short humerus (HP:0005792)2.71637724
53Ectropion (HP:0000656)2.70926959
54Increased IgE level (HP:0003212)2.69959505
55Anonychia (HP:0001798)2.68719116
56Pili torti (HP:0003777)2.67711794
57Rhabdomyosarcoma (HP:0002859)2.64933640
58Fused cervical vertebrae (HP:0002949)2.64149265
59Hypotrichosis (HP:0001006)2.61272031
60Abnormality of the labia majora (HP:0012881)2.59906774
61Abnormality of the umbilical cord (HP:0010881)2.56900908
62Absent thumb (HP:0009777)2.56229103
63Abnormality of the labia minora (HP:0012880)2.56142753
64Colon cancer (HP:0003003)2.55421789
65Concave nail (HP:0001598)2.55209405
66Congenital ichthyosiform erythroderma (HP:0007431)2.54230993
67Oligodontia (HP:0000677)2.54214350
68Abnormal number of erythroid precursors (HP:0012131)2.53158379
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48417859
70Ureteral duplication (HP:0000073)2.47800057
71Patellar aplasia (HP:0006443)2.47512808
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46972657
73Abnormality of the anterior horn cell (HP:0006802)2.43728837
74Degeneration of anterior horn cells (HP:0002398)2.43728837
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43178747
76Woolly hair (HP:0002224)2.41461905
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.40504304
78Nail dystrophy (HP:0008404)2.40228612
79Right ventricular cardiomyopathy (HP:0011663)2.39249691
80Secondary amenorrhea (HP:0000869)2.38769479
81Aplasia/Hypoplasia of the patella (HP:0006498)2.38605889
82Abnormality of nail color (HP:0100643)2.37709577
83Astrocytoma (HP:0009592)2.36141224
84Abnormality of the astrocytes (HP:0100707)2.36141224
85Chromsome breakage (HP:0040012)2.34945335
86Tongue fasciculations (HP:0001308)2.32696721
87Hyperhidrosis (HP:0000975)2.32577015
88Microretrognathia (HP:0000308)2.32448439
89Carious teeth (HP:0000670)2.31054452
90Shawl scrotum (HP:0000049)2.30248514
91Macrocytic anemia (HP:0001972)2.29954828
92Abnormal trabecular bone morphology (HP:0100671)2.29455375
93Abnormality of oral frenula (HP:0000190)2.28594089
94Abnormality of the distal phalanges of the toes (HP:0010182)2.27098663
95Muscle fibrillation (HP:0010546)2.26687571
96Impulsivity (HP:0100710)2.26523017
97Fragile nails (HP:0001808)2.24580762
98Testicular atrophy (HP:0000029)2.23821134
99Missing ribs (HP:0000921)2.22885983
100Medulloblastoma (HP:0002885)2.22711415
101Abnormality of the preputium (HP:0100587)2.22506484
102Abnormal umbilical cord blood vessels (HP:0011403)2.21673953
103Single umbilical artery (HP:0001195)2.21673953
104Abnormality of the fetal cardiovascular system (HP:0010948)2.21673953
105Esophageal atresia (HP:0002032)2.21135328
106Abnormal hemoglobin (HP:0011902)2.19230247
107Stenosis of the external auditory canal (HP:0000402)2.17808849
108Angiofibromas (HP:0010615)2.16674677
109Adenoma sebaceum (HP:0009720)2.16674677
110Parakeratosis (HP:0001036)2.14861057
111Meckel diverticulum (HP:0002245)2.14158882
112Glioma (HP:0009733)2.12153678
113Abnormality of the ileum (HP:0001549)2.10192854
114Ventricular tachycardia (HP:0004756)2.07569368
115Distal lower limb muscle weakness (HP:0009053)2.07304499
116Neoplasm of striated muscle (HP:0009728)2.05573002
117Hypodontia (HP:0000668)2.05102361
118Pallor (HP:0000980)2.03842730
119Abnormality of the fingernails (HP:0001231)2.02526529
120Breech presentation (HP:0001623)2.01869147
121Lip pit (HP:0100267)2.01634076
122Agnosia (HP:0010524)2.00841017
123Hypohidrosis (HP:0000966)1.98929106
124Rectal fistula (HP:0100590)1.98842646
125Rectovaginal fistula (HP:0000143)1.98842646
126Dehydration (HP:0001944)1.98261887
127Atresia of the external auditory canal (HP:0000413)1.98079352
128Supernumerary spleens (HP:0009799)1.96477136
129Xerostomia (HP:0000217)1.95456709
130Neoplasm of the pancreas (HP:0002894)1.94218333
131Spinal muscular atrophy (HP:0007269)1.94014028
132Bilateral microphthalmos (HP:0007633)1.93724909
133Laryngomalacia (HP:0001601)1.92587469
134Congenital, generalized hypertrichosis (HP:0004540)1.91701818
135Glossoptosis (HP:0000162)1.91392476
136Fasciculations (HP:0002380)1.91250977
137Plantar hyperkeratosis (HP:0007556)1.91172074
138Septate vagina (HP:0001153)1.90648787
139Cheilitis (HP:0100825)1.89963158
140Biliary tract neoplasm (HP:0100574)1.89829593
141Progressive muscle weakness (HP:0003323)1.89460520
142Axonal loss (HP:0003447)1.88939684
143Horseshoe kidney (HP:0000085)1.88077943
144Acanthosis nigricans (HP:0000956)1.87449502
145Blepharitis (HP:0000498)1.87107476
146Myopathic facies (HP:0002058)1.86998868
147Difficulty climbing stairs (HP:0003551)1.86697952
148Premature graying of hair (HP:0002216)1.84674414
149Short nail (HP:0001799)1.84161616
150Alopecia of scalp (HP:0002293)1.84086659
151Split foot (HP:0001839)1.83687051
152Nasolacrimal duct obstruction (HP:0000579)1.82112604
153Abnormality of abdominal situs (HP:0011620)1.81263666
154Abdominal situs inversus (HP:0003363)1.81263666
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.81014510
156Abnormality of the dental root (HP:0006486)1.77337403
157Taurodontia (HP:0000679)1.77337403
158Abnormality of permanent molar morphology (HP:0011071)1.77337403
159Poikiloderma (HP:0001029)1.75786153
160Skin ulcer (HP:0200042)1.75287415
161Pustule (HP:0200039)1.75053106
162Absent hair (HP:0002298)1.73773339
163Broad face (HP:0000283)1.72938859
164Follicular hyperkeratosis (HP:0007502)1.72021616
165Amelogenesis imperfecta (HP:0000705)1.70786490
166Epidermoid cyst (HP:0200040)1.67956162
167Labial hypoplasia (HP:0000066)1.67671359
168Squamous cell carcinoma (HP:0002860)1.67200710
169Curly hair (HP:0002212)1.66120192
170Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.64449016
171Abnormality of molar (HP:0011077)1.61109116
172Abnormality of molar morphology (HP:0011070)1.61109116
173Abnormality of the gastric mucosa (HP:0004295)1.60459972
174Abnormality of hair growth rate (HP:0011363)1.59128060
175Slow-growing hair (HP:0002217)1.59128060
176Hypoplastic female external genitalia (HP:0012815)1.58504281
177Hypoplasia of the uterus (HP:0000013)1.55982513
178Duplicated collecting system (HP:0000081)1.55795031
179Hoarse voice (HP:0001609)1.52359349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.82001450
2WEE14.21400488
3BUB14.19225862
4EPHB23.22794904
5TTK3.00951916
6RPS6KB22.89136998
7NEK12.86983644
8CDK122.84454771
9MAP3K92.72551553
10SIK12.41963660
11LMTK22.39715208
12STK242.20805515
13RIPK12.20449012
14AKT32.10762081
15NEK21.98873303
16TESK21.97660424
17MAPKAPK31.93565699
18NTRK11.92180275
19MAP3K21.91727085
20NME21.89282398
21PLK11.82614181
22TSSK61.82317541
23IRAK31.81303753
24EIF2AK11.74326072
25CDK71.68242436
26LATS21.63990163
27STK101.63727801
28PLK41.61545485
29CDC71.61517228
30EPHB11.55239707
31FLT31.51651975
32PAK41.46783398
33AURKA1.45485532
34PIM21.43764947
35MAP3K121.42960097
36PBK1.42764344
37CHEK21.38664282
38SMG11.36681512
39AURKB1.34678873
40MAP3K81.34309128
41MAP3K111.34222434
42SRPK11.33648797
43TESK11.33365196
44MAP3K31.33125293
45PNCK1.32349796
46PDGFRA1.31950241
47DYRK31.31051439
48PRKCI1.30299016
49MAP3K61.28864028
50STK161.11420228
51EIF2AK31.08804879
52PTK61.06256675
53TAOK21.05740349
54ACVR1B1.03476961
55BRSK21.02546365
56STK38L1.01983568
57ZAK1.00704291
58GRK60.98227787
59MST40.96760614
60ALK0.95422136
61PAK10.93835372
62PLK30.93275779
63MAP2K20.92865712
64BMX0.91368097
65MET0.91008915
66CDK40.88297995
67CHEK10.87734642
68NME10.85943763
69MATK0.85314067
70KSR20.83530608
71ATR0.82307309
72RPS6KA40.81911155
73PDK20.81224281
74TYRO30.79948225
75BRAF0.79814129
76MAP3K130.79711946
77FER0.76835836
78PDK30.76301251
79PDK40.76301251
80TLK10.75228990
81CDK20.71887778
82PRPF4B0.71647754
83DDR20.69008151
84TRPM70.68809829
85MTOR0.68555918
86LIMK10.67704223
87GRK50.65904144
88MAP3K10.64747652
89LRRK20.63372580
90TGFBR20.63371689
91PIM10.61833625
92STK380.61673996
93CSNK1E0.61479121
94PASK0.61371886
95ERN10.60674321
96EEF2K0.59798177
97SCYL20.59337638
98SIK30.58041587
99PDGFRB0.57857885
100VRK10.57467102
101RAF10.55481581
102DYRK20.54258015
103ILK0.53128102
104CSNK2A20.52637651
105AKT20.52369498
106PKN20.51593369
107GRK10.50900017
108PRKD20.49951326
109ABL20.49828010
110CDK60.49749746
111ATM0.49734429
112TAOK10.49709221
113CSNK2A10.49454129
114TTN0.47105950
115ERBB40.46582159
116STK30.46490067
117ICK0.43980320
118BCKDK0.42906351
119TRIB30.42842035
120ARAF0.42527574
121KSR10.42064989
122BRSK10.41058693
123RPS6KA20.40885728
124MOS0.40462922
125CDK10.39273909
126ROCK20.38060499
127PTK20.37713379
128MAP2K60.36959404
129MST1R0.35491344
130PRKG20.34926240
131MELK0.34506832
132TGFBR10.34292986
133LATS10.32130496
134EIF2AK20.31977436
135FGFR10.31456333
136PHKG20.30548758
137PHKG10.30548758
138MKNK10.30130343
139ADRBK20.29899998
140STK40.29341973
141MAPKAPK20.28876784
142BCR0.27192852
143MAP2K10.25067881
144IRAK20.22120165
145GSK3A0.21651895
146RPS6KA10.20889054
147CDK80.19230002
148NEK60.18467371
149SGK30.18430537
150CDC42BPA0.17866186
151IKBKB0.17401992
152MAPKAPK50.17104798
153ERBB20.16851183
154MUSK0.16350889
155ROCK10.15421630
156RET0.15341644
157CDK90.14697799
158FGR0.14623477
159CAMK2G0.13821711

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.00128400
2Ribosome_Homo sapiens_hsa030103.98734082
3Proteasome_Homo sapiens_hsa030503.97548300
4ECM-receptor interaction_Homo sapiens_hsa045123.96011601
5DNA replication_Homo sapiens_hsa030303.72590216
6Mismatch repair_Homo sapiens_hsa034303.55856849
7RNA transport_Homo sapiens_hsa030133.27996889
8RNA polymerase_Homo sapiens_hsa030203.08183757
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77448796
10Spliceosome_Homo sapiens_hsa030402.70868733
11Base excision repair_Homo sapiens_hsa034102.39934067
12Nucleotide excision repair_Homo sapiens_hsa034202.30853902
13Focal adhesion_Homo sapiens_hsa045102.27818950
14Homologous recombination_Homo sapiens_hsa034402.25025416
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.21028857
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18390762
17One carbon pool by folate_Homo sapiens_hsa006702.17519466
18Cell cycle_Homo sapiens_hsa041102.14757967
19Pyrimidine metabolism_Homo sapiens_hsa002402.10016552
20Amoebiasis_Homo sapiens_hsa051461.91770734
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.83720464
22p53 signaling pathway_Homo sapiens_hsa041151.83369749
23Fructose and mannose metabolism_Homo sapiens_hsa000511.81762587
24Vitamin B6 metabolism_Homo sapiens_hsa007501.77933758
25ErbB signaling pathway_Homo sapiens_hsa040121.76255930
26Fanconi anemia pathway_Homo sapiens_hsa034601.64514131
27VEGF signaling pathway_Homo sapiens_hsa043701.60634156
28Folate biosynthesis_Homo sapiens_hsa007901.55425813
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54442867
30Chronic myeloid leukemia_Homo sapiens_hsa052201.50008055
31Axon guidance_Homo sapiens_hsa043601.45188455
32mRNA surveillance pathway_Homo sapiens_hsa030151.35989081
33Basal transcription factors_Homo sapiens_hsa030221.35907675
34Steroid biosynthesis_Homo sapiens_hsa001001.31410251
35Glutathione metabolism_Homo sapiens_hsa004801.31368844
36Pancreatic cancer_Homo sapiens_hsa052121.30228018
37Pentose phosphate pathway_Homo sapiens_hsa000301.28010313
38RNA degradation_Homo sapiens_hsa030181.27330975
39Renal cell carcinoma_Homo sapiens_hsa052111.25768134
40Arachidonic acid metabolism_Homo sapiens_hsa005901.24427903
41Toxoplasmosis_Homo sapiens_hsa051451.22548278
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18700465
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16093399
44Hippo signaling pathway_Homo sapiens_hsa043901.15902398
45GnRH signaling pathway_Homo sapiens_hsa049121.13821326
46Endocytosis_Homo sapiens_hsa041441.12894575
47Salmonella infection_Homo sapiens_hsa051321.08839291
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06591933
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06534597
50Glioma_Homo sapiens_hsa052141.03934977
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.03652994
52Sulfur metabolism_Homo sapiens_hsa009201.03638529
53Galactose metabolism_Homo sapiens_hsa000521.02644404
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02555119
55Insulin signaling pathway_Homo sapiens_hsa049101.00004226
56Endometrial cancer_Homo sapiens_hsa052130.99817472
57Acute myeloid leukemia_Homo sapiens_hsa052210.98425113
58Tight junction_Homo sapiens_hsa045300.97448630
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97404342
60Epstein-Barr virus infection_Homo sapiens_hsa051690.97162778
61Biosynthesis of amino acids_Homo sapiens_hsa012300.97159866
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96902385
63Linoleic acid metabolism_Homo sapiens_hsa005910.95821373
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94581075
65Non-homologous end-joining_Homo sapiens_hsa034500.94538139
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93142787
67Regulation of autophagy_Homo sapiens_hsa041400.92728011
68Prion diseases_Homo sapiens_hsa050200.92153048
69Purine metabolism_Homo sapiens_hsa002300.89279762
70Inositol phosphate metabolism_Homo sapiens_hsa005620.88927558
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87542420
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85869994
73Hepatitis C_Homo sapiens_hsa051600.83140059
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83112049
75Sulfur relay system_Homo sapiens_hsa041220.81538030
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80527202
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.80469285
78Basal cell carcinoma_Homo sapiens_hsa052170.80362934
79Circadian rhythm_Homo sapiens_hsa047100.79188644
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79132537
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78870778
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78837316
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78073152
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76311980
85Dilated cardiomyopathy_Homo sapiens_hsa054140.75148480
86Thyroid cancer_Homo sapiens_hsa052160.74913291
87Hedgehog signaling pathway_Homo sapiens_hsa043400.74353836
88Carbon metabolism_Homo sapiens_hsa012000.74230421
89Oocyte meiosis_Homo sapiens_hsa041140.74189657
90Histidine metabolism_Homo sapiens_hsa003400.72596646
91Fatty acid elongation_Homo sapiens_hsa000620.68872582
92Arginine biosynthesis_Homo sapiens_hsa002200.67154718
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64904405
94Ether lipid metabolism_Homo sapiens_hsa005650.64881153
95Non-small cell lung cancer_Homo sapiens_hsa052230.64794146
96Estrogen signaling pathway_Homo sapiens_hsa049150.64545618
97Adherens junction_Homo sapiens_hsa045200.61986026
98Bladder cancer_Homo sapiens_hsa052190.61283674
99MicroRNAs in cancer_Homo sapiens_hsa052060.60681419
100Selenocompound metabolism_Homo sapiens_hsa004500.59404081
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58825211
102Viral carcinogenesis_Homo sapiens_hsa052030.56457835
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55998998
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55481224
105Vibrio cholerae infection_Homo sapiens_hsa051100.54908253
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.53831330
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53455191
108mTOR signaling pathway_Homo sapiens_hsa041500.53432527
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51790303
110TGF-beta signaling pathway_Homo sapiens_hsa043500.50399549
111HTLV-I infection_Homo sapiens_hsa051660.49596353
112N-Glycan biosynthesis_Homo sapiens_hsa005100.49282659
113Tyrosine metabolism_Homo sapiens_hsa003500.47633553
114Melanogenesis_Homo sapiens_hsa049160.46761026
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.46598265
116Small cell lung cancer_Homo sapiens_hsa052220.45822046
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45811800
118Dorso-ventral axis formation_Homo sapiens_hsa043200.45682811
119Fatty acid biosynthesis_Homo sapiens_hsa000610.45455348
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.45000840
121TNF signaling pathway_Homo sapiens_hsa046680.44862825
122Chemical carcinogenesis_Homo sapiens_hsa052040.43931746
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43640517
124Choline metabolism in cancer_Homo sapiens_hsa052310.43556495
125Rap1 signaling pathway_Homo sapiens_hsa040150.43433277
126Huntingtons disease_Homo sapiens_hsa050160.42772984
127Arginine and proline metabolism_Homo sapiens_hsa003300.42390919
128Glucagon signaling pathway_Homo sapiens_hsa049220.40987188
129Sphingolipid metabolism_Homo sapiens_hsa006000.40795429
130Insulin resistance_Homo sapiens_hsa049310.40352258
131Antigen processing and presentation_Homo sapiens_hsa046120.40074107
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39159721
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39146168
134Prostate cancer_Homo sapiens_hsa052150.39097420
135Metabolic pathways_Homo sapiens_hsa011000.36787727
136Melanoma_Homo sapiens_hsa052180.35333068
137Renin-angiotensin system_Homo sapiens_hsa046140.34342194
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33394480
139Shigellosis_Homo sapiens_hsa051310.30534906
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29875185
141Herpes simplex infection_Homo sapiens_hsa051680.28528249
142Retinol metabolism_Homo sapiens_hsa008300.28256128
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27961673
144Proteoglycans in cancer_Homo sapiens_hsa052050.27911831
145Apoptosis_Homo sapiens_hsa042100.27653278
146Pathways in cancer_Homo sapiens_hsa052000.27553068
147Legionellosis_Homo sapiens_hsa051340.27363002
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27319037
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27039708
150Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25781841
151Notch signaling pathway_Homo sapiens_hsa043300.22291250
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.22026005
153Systemic lupus erythematosus_Homo sapiens_hsa053220.19445840
154Fat digestion and absorption_Homo sapiens_hsa049750.18946250
155Wnt signaling pathway_Homo sapiens_hsa043100.18567774
156HIF-1 signaling pathway_Homo sapiens_hsa040660.17707206
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.15891960
158Phenylalanine metabolism_Homo sapiens_hsa003600.15881596
159Other glycan degradation_Homo sapiens_hsa005110.15642603
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15538639

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »