GJB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta-type (group I) connexin family. The encoded protein is a gap junction protein involved in intercellular communication related to epidermal differentiation and environmental sensing. This gene has been linked to non-small cell lung cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)7.90496368
2negative regulation of keratinocyte proliferation (GO:0010839)7.73021345
3cell-substrate junction assembly (GO:0007044)7.64044672
4establishment of skin barrier (GO:0061436)7.42326452
5viral transcription (GO:0019083)7.17240328
6regulation of water loss via skin (GO:0033561)7.12529273
7ribosomal small subunit biogenesis (GO:0042274)7.07737320
8translational termination (GO:0006415)6.90973189
9maturation of SSU-rRNA (GO:0030490)6.63874375
10keratinocyte proliferation (GO:0043616)6.11757572
11sphingoid metabolic process (GO:0046519)6.03835080
12translational elongation (GO:0006414)5.87529781
13ribosomal small subunit assembly (GO:0000028)5.76953775
14regulation of keratinocyte proliferation (GO:0010837)5.71904197
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.59048646
16glucosamine-containing compound catabolic process (GO:1901072)5.55892675
17protein targeting to ER (GO:0045047)5.47367432
18surfactant homeostasis (GO:0043129)5.47056609
19positive regulation of epidermis development (GO:0045684)5.46183455
20cotranslational protein targeting to membrane (GO:0006613)5.46050368
21keratinocyte development (GO:0003334)5.44938925
22sphingosine metabolic process (GO:0006670)5.44203643
23ribosomal large subunit biogenesis (GO:0042273)5.40220956
24viral life cycle (GO:0019058)5.39577360
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.37575095
26cellular protein complex disassembly (GO:0043624)5.36755651
27translational initiation (GO:0006413)5.32641724
28establishment of protein localization to endoplasmic reticulum (GO:0072599)5.25566631
29regulation of hair follicle development (GO:0051797)5.21752720
30protein localization to endoplasmic reticulum (GO:0070972)5.13789936
31amino sugar catabolic process (GO:0046348)4.92553932
32gap junction assembly (GO:0016264)4.92334541
33establishment of planar polarity (GO:0001736)4.88751309
34establishment of tissue polarity (GO:0007164)4.88751309
35keratinocyte differentiation (GO:0030216)4.88750419
36diol metabolic process (GO:0034311)4.88486615
37regulation of chemokine secretion (GO:0090196)4.82149976
38multicellular organismal water homeostasis (GO:0050891)4.72823489
39positive regulation of hair cycle (GO:0042635)4.63487544
40positive regulation of hair follicle development (GO:0051798)4.63487544
41protein complex disassembly (GO:0043241)4.56480028
42keratinization (GO:0031424)4.54808785
43polarized epithelial cell differentiation (GO:0030859)4.49346113
44chemical homeostasis within a tissue (GO:0048875)4.47310559
45cyclooxygenase pathway (GO:0019371)4.42382549
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.41689235
47intermediate filament cytoskeleton organization (GO:0045104)4.33111227
48epithelial cell differentiation involved in prostate gland development (GO:0060742)4.30934023
49macromolecular complex disassembly (GO:0032984)4.25748686
50intestinal epithelial cell development (GO:0060576)4.24077064
51regulation of epidermis development (GO:0045682)4.19334299
52formation of translation preinitiation complex (GO:0001731)4.18727312
53positive regulation of keratinocyte differentiation (GO:0045618)4.17740701
54intermediate filament-based process (GO:0045103)4.16379362
55prostanoid biosynthetic process (GO:0046457)4.09620118
56prostaglandin biosynthetic process (GO:0001516)4.09620118
57positive regulation of interleukin-8 secretion (GO:2000484)4.07551252
58regulation of cell proliferation involved in kidney development (GO:1901722)4.03857920
59hypotonic response (GO:0006971)4.03681628
60skin morphogenesis (GO:0043589)4.00571924
61water homeostasis (GO:0030104)3.99736776
62ribonucleoprotein complex biogenesis (GO:0022613)3.99667271
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95685734
64regulation of phospholipase A2 activity (GO:0032429)3.94327362
65cell adhesion mediated by integrin (GO:0033627)3.90935511
66epidermal cell differentiation (GO:0009913)3.88331415
67regulation of hair cycle (GO:0042634)3.87974301
68lateral sprouting from an epithelium (GO:0060601)3.87509134
69hemidesmosome assembly (GO:0031581)3.82621103
70protein targeting to membrane (GO:0006612)3.78740417
71regulation of keratinocyte differentiation (GO:0045616)3.76465058
72regulation of transforming growth factor beta2 production (GO:0032909)3.75234335
73translation (GO:0006412)3.67273115
74regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.64176258
75negative regulation of chondrocyte differentiation (GO:0032331)3.60790788
76cardiac right ventricle morphogenesis (GO:0003215)3.59431708
77regulation of posttranscriptional gene silencing (GO:0060147)3.57625687
78regulation of gene silencing by miRNA (GO:0060964)3.57625687
79regulation of gene silencing by RNA (GO:0060966)3.57625687
80nuclear-transcribed mRNA catabolic process (GO:0000956)3.56711044
81regulation of histone H3-K27 methylation (GO:0061085)3.54699287
82hair cycle (GO:0042633)3.53465957
83molting cycle (GO:0042303)3.53465957
84skin development (GO:0043588)3.52889415
85regulation of epidermal cell differentiation (GO:0045604)3.47995948
86mesodermal cell differentiation (GO:0048333)3.47126907
87positive regulation of chemokine secretion (GO:0090197)3.45453267
88protein localization to endosome (GO:0036010)3.42640935
89mRNA catabolic process (GO:0006402)3.38206584
90cell junction assembly (GO:0034329)3.36809143
91eyelid development in camera-type eye (GO:0061029)3.34422175
92negative regulation of epidermis development (GO:0045683)3.34106439
93ventricular cardiac muscle cell action potential (GO:0086005)3.28163758
94cell junction organization (GO:0034330)3.23535159
95long-chain fatty acid biosynthetic process (GO:0042759)3.22294094
96phosphatidylinositol acyl-chain remodeling (GO:0036149)3.21918451
97G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.15881316
98lipoxygenase pathway (GO:0019372)3.15440904
99cytoskeletal anchoring at plasma membrane (GO:0007016)3.15058118
100trophectodermal cell differentiation (GO:0001829)3.13059904
101prostanoid metabolic process (GO:0006692)3.11846320
102prostaglandin metabolic process (GO:0006693)3.11846320
103RNA catabolic process (GO:0006401)3.11544708
104planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10464618
105phosphatidylserine acyl-chain remodeling (GO:0036150)3.10381147
106negative regulation by host of viral transcription (GO:0043922)3.04347930
107epithelial cell-cell adhesion (GO:0090136)3.03379392
108regulation of ruffle assembly (GO:1900027)3.01668059
109* epithelium development (GO:0060429)3.00371522
110* epidermis development (GO:0008544)2.99911584
111regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.99299210
112cellular copper ion homeostasis (GO:0006878)2.98967629
113rRNA processing (GO:0006364)2.98682994
114morphogenesis of embryonic epithelium (GO:0016331)2.97570116
115endodermal cell differentiation (GO:0035987)2.94440406
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93465334
117primary alcohol catabolic process (GO:0034310)2.91992515
118atrioventricular valve morphogenesis (GO:0003181)2.91965002
119ectoderm development (GO:0007398)2.91915785
120peptide cross-linking (GO:0018149)2.90435128
121regulation of interleukin-8 secretion (GO:2000482)2.89824079
122branching involved in labyrinthine layer morphogenesis (GO:0060670)2.89321949
123rRNA metabolic process (GO:0016072)2.86911288
124hair follicle morphogenesis (GO:0031069)2.86882558
125negative regulation of interleukin-2 production (GO:0032703)2.86808514
126cell-substrate adherens junction assembly (GO:0007045)2.86375153
127focal adhesion assembly (GO:0048041)2.86375153
128ribosome assembly (GO:0042255)2.85037019
129cellular response to interferon-alpha (GO:0035457)2.83612879
130cardiolipin metabolic process (GO:0032048)2.79743367
131proteasome assembly (GO:0043248)2.79625487
132regulation of transforming growth factor beta1 production (GO:0032908)2.79492610
133L-serine transport (GO:0015825)2.79157892
134intermediate filament organization (GO:0045109)2.78446808
135fatty acid elongation (GO:0030497)2.78007658
136blastocyst development (GO:0001824)2.74199368
137gland morphogenesis (GO:0022612)2.73855787
138establishment of protein localization to membrane (GO:0090150)2.73576178
139cellular component biogenesis (GO:0044085)2.71442292
140positive regulation of transcription regulatory region DNA binding (GO:2000679)2.69372976
141regulation of heart rate by cardiac conduction (GO:0086091)2.68847577
142negative regulation of stem cell proliferation (GO:2000647)2.68742745
143hair cycle process (GO:0022405)2.68488562
144molting cycle process (GO:0022404)2.68488562
145regulation of metalloenzyme activity (GO:0048552)2.67728406
146negative regulation of kidney development (GO:0090185)2.66310912
147wound healing (GO:0042060)2.64854522
148negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.63768178
149lung-associated mesenchyme development (GO:0060484)2.59466060
150membrane raft organization (GO:0031579)2.59198356
151regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.59111860
152renal system development (GO:0072001)2.58792154
153cell communication involved in cardiac conduction (GO:0086065)2.57283852
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.56898202
155mitotic nuclear envelope reassembly (GO:0007084)2.56467521
156nuclear envelope reassembly (GO:0031468)2.56467521
157mammary gland epithelial cell proliferation (GO:0033598)2.55719320
158negative regulation of cell fate specification (GO:0009996)2.55220305
159negative regulation of interferon-gamma production (GO:0032689)2.54930537
160positive regulation of epidermal cell differentiation (GO:0045606)2.54122265
161regulation of cardioblast differentiation (GO:0051890)2.53941839
162arachidonic acid secretion (GO:0050482)2.52866496
163icosanoid secretion (GO:0032309)2.52866496
164peptidyl-tyrosine autophosphorylation (GO:0038083)2.52140085
165membrane tubulation (GO:0097320)2.51866338
166natural killer cell mediated immunity (GO:0002228)2.51215004
167natural killer cell mediated cytotoxicity (GO:0042267)2.51215004
168endosome organization (GO:0007032)2.50493626
169positive regulation of protein export from nucleus (GO:0046827)2.49425119
170negative regulation of cartilage development (GO:0061037)2.46901316
171COPI coating of Golgi vesicle (GO:0048205)2.44363638
172Golgi transport vesicle coating (GO:0048200)2.44363638
173adherens junction organization (GO:0034332)2.43835646
174desmosome organization (GO:0002934)11.0420269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.77412031
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.26631884
3E2F7_22180533_ChIP-Seq_HELA_Human2.91002469
4MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89310207
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.83497868
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.83497868
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.83497868
8TCF3_18692474_ChIP-Seq_MEFs_Mouse2.31608660
9ZNF263_19887448_ChIP-Seq_K562_Human2.26296554
10* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.15541650
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11022196
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09487796
13* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.08112325
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05920986
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05027705
16TP63_17297297_ChIP-ChIP_HaCaT_Human12.8387225
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.99988313
18NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97815321
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.96451685
20* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.95855679
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90058912
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85842578
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84039368
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79285797
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.77245920
26TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75741463
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.73558467
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71390820
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69442011
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.58928743
31UBF1/2_26484160_Chip-Seq_HMECs_Human1.58545321
32* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.58247859
33* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.57194181
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57190412
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.55419650
36* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54631907
37SOX2_20726797_ChIP-Seq_SW620_Human1.53752670
38SOX2_18692474_ChIP-Seq_MEFs_Mouse1.53403571
39* TP63_23658742_ChIP-Seq_EP156T_Human1.53188150
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.51686758
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50714429
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49520382
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.48429578
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46572246
45XRN2_22483619_ChIP-Seq_HELA_Human1.45297887
46* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44836808
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44813946
48* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44615377
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43849469
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41036573
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40217806
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39105555
53* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39076992
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38659865
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38144558
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.36646685
57* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35500713
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33808775
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32357374
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32281094
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32281094
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31895787
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31580002
64TTF2_22483619_ChIP-Seq_HELA_Human1.31221774
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.31060929
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.29221297
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.27522495
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27419131
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25168509
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24703211
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21841722
72KLF5_25053715_ChIP-Seq_YYC3_Human1.21697288
73ATF3_27146783_Chip-Seq_COLON_Human1.20227506
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19227748
75* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18569335
76* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16094813
77CLOCK_20551151_ChIP-Seq_293T_Human1.15117186
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13823917
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13179343
80* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10517956
81* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08848793
82DCP1A_22483619_ChIP-Seq_HELA_Human1.06780111
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06383736
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05754658
85* YY1_22570637_ChIP-Seq_MALME-3M_Human1.04977339
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04737195
87* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01489386
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01020340
89LXR_22292898_ChIP-Seq_THP-1_Human0.99687064
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.98666977
91PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98234130
92* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98088928
93SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97077862
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96733889
95AR_21909140_ChIP-Seq_LNCAP_Human0.96515692
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96194199
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95384172
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95193130
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95113439
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94369430
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.92363419
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92307332
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90341746
104RACK7_27058665_Chip-Seq_MCF-7_Human0.90115600
105POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89930274
106GATA4_25053715_ChIP-Seq_YYC3_Human0.89303557
107* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88633587
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88511472
109* KAP1_27257070_Chip-Seq_ESCs_Mouse0.88108976
110VDR_23849224_ChIP-Seq_CD4+_Human0.87549771
111YY1_21170310_ChIP-Seq_MESCs_Mouse0.87499388
112GATA2_21666600_ChIP-Seq_HMVEC_Human0.87039516
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86904980
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86897267
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.86442070
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86232466
117CJUN_26792858_Chip-Seq_BT549_Human0.86199507
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85769307
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85384343
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85168117
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84791693
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84364009
123* TP63_22573176_ChIP-Seq_HFKS_Human0.83368306
124TP53_18474530_ChIP-ChIP_U2OS_Human0.83107982
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82464564
126SMC4_20622854_ChIP-Seq_HELA_Human0.81526190
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81015692
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80490415
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80480049
130GATA6_25053715_ChIP-Seq_YYC3_Human0.79458684
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.79427960
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.79295257
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78539419
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.77005931
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76823636
136* TCF4_18268006_ChIP-ChIP_LS174T_Human0.75807130
137TP53_22127205_ChIP-Seq_IMR90_Human0.73042516
138CTCF_27219007_Chip-Seq_Bcells_Human0.72504056
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.69446584
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.69044745
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.69044745
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.67772716
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.67595952
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66479835
145EGR1_19032775_ChIP-ChIP_M12_Human0.66301366
146* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.65678994
147CHD1_26751641_Chip-Seq_LNCaP_Human0.64618806
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63011693
149* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59568903
150P68_20966046_ChIP-Seq_HELA_Human0.55814655
151BCOR_27268052_Chip-Seq_Bcells_Human0.55423028
152E2F1_20622854_ChIP-Seq_HELA_Human0.54682317
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.54383712
154AHR_22903824_ChIP-Seq_MCF-7_Human0.54198494
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.53322565
156TP53_23651856_ChIP-Seq_MEFs_Mouse0.53156730
157ELF5_23300383_ChIP-Seq_T47D_Human0.51487599
158KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.50772085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.29589089
2MP0003941_abnormal_skin_development5.66061605
3MP0005501_abnormal_skin_physiology4.17279667
4MP0004381_abnormal_hair_follicle4.07244113
5MP0010234_abnormal_vibrissa_follicle3.78853747
6MP0005275_abnormal_skin_tensile3.70208505
7MP0001216_abnormal_epidermal_layer3.03107314
8MP0003453_abnormal_keratinocyte_physiol2.96169704
9MP0010352_gastrointestinal_tract_polyps2.85396116
10MP0000383_abnormal_hair_follicle2.80696283
11MP0002060_abnormal_skin_morphology2.79242751
12MP0002254_reproductive_system_inflammat2.52842487
13MP0003566_abnormal_cell_adhesion2.52794724
14MP0005409_darkened_coat_color2.52125705
15MP0004957_abnormal_blastocyst_morpholog2.48982259
16MP0010678_abnormal_skin_adnexa2.47448992
17MP0002098_abnormal_vibrissa_morphology2.46211088
18MP0010771_integument_phenotype2.41947973
19MP0009379_abnormal_foot_pigmentation2.40572804
20MP0002234_abnormal_pharynx_morphology2.38847119
21MP0003136_yellow_coat_color2.33664523
22MP0000647_abnormal_sebaceous_gland2.29329541
23MP0003693_abnormal_embryo_hatching2.26789382
24MP0000566_synostosis2.21337363
25MP0003705_abnormal_hypodermis_morpholog2.17295592
26MP0001849_ear_inflammation2.12316978
27MP0000377_abnormal_hair_follicle2.03600468
28MP0000467_abnormal_esophagus_morphology1.92538732
29MP0000678_abnormal_parathyroid_gland1.74154236
30MP0005023_abnormal_wound_healing1.68817674
31MP0004185_abnormal_adipocyte_glucose1.63208820
32MP0003718_maternal_effect1.60125206
33MP0003111_abnormal_nucleus_morphology1.57986668
34MP0004947_skin_inflammation1.56861594
35MP0000427_abnormal_hair_cycle1.55323588
36MP0000762_abnormal_tongue_morphology1.49764458
37MP0008260_abnormal_autophagy1.48883255
38MP0005451_abnormal_body_composition1.47178390
39MP0000579_abnormal_nail_morphology1.45719565
40MP0010030_abnormal_orbit_morphology1.45219485
41MP0009931_abnormal_skin_appearance1.41947049
42MP0001346_abnormal_lacrimal_gland1.41093887
43MP0003806_abnormal_nucleotide_metabolis1.41068074
44MP0003315_abnormal_perineum_morphology1.40790225
45MP0001191_abnormal_skin_condition1.38617120
46MP0001243_abnormal_dermal_layer1.30982103
47MP0003191_abnormal_cellular_cholesterol1.28833837
48MP0003950_abnormal_plasma_membrane1.24162172
49MP0005076_abnormal_cell_differentiation1.23674343
50MP0003011_delayed_dark_adaptation1.21869911
51MP0008932_abnormal_embryonic_tissue1.20855132
52MP0000367_abnormal_coat/_hair1.16205338
53MP0010094_abnormal_chromosome_stability1.15862535
54MP0002277_abnormal_respiratory_mucosa1.12244439
55MP0004272_abnormal_basement_membrane1.12227889
56MP0003077_abnormal_cell_cycle1.12136222
57MP0000516_abnormal_urinary_system1.09837704
58MP0005367_renal/urinary_system_phenotyp1.09837704
59MP0009780_abnormal_chondrocyte_physiolo1.06236740
60MP0002009_preneoplasia1.05825058
61MP0004264_abnormal_extraembryonic_tissu1.05572974
62MP0008057_abnormal_DNA_replication1.05384052
63MP0000627_abnormal_mammary_gland1.01794910
64MP0000537_abnormal_urethra_morphology0.98571885
65MP0003786_premature_aging0.97199017
66MP0008004_abnormal_stomach_pH0.96529557
67MP0009053_abnormal_anal_canal0.95421431
68MP0003123_paternal_imprinting0.94364988
69MP0002111_abnormal_tail_morphology0.92428803
70MP0008789_abnormal_olfactory_epithelium0.90946579
71MP0004019_abnormal_vitamin_homeostasis0.88846753
72MP0001340_abnormal_eyelid_morphology0.86130164
73MP0003938_abnormal_ear_development0.85826623
74MP0000858_altered_metastatic_potential0.84945569
75MP0005075_abnormal_melanosome_morpholog0.82116704
76MP0004885_abnormal_endolymph0.81848567
77MP0003567_abnormal_fetal_cardiomyocyte0.81387202
78MP0000350_abnormal_cell_proliferation0.80810635
79MP0003119_abnormal_digestive_system0.78263684
80MP0008007_abnormal_cellular_replicative0.77216453
81MP0005360_urolithiasis0.72623253
82MP0005508_abnormal_skeleton_morphology0.72362496
83* MP0002086_abnormal_extraembryonic_tissu0.71564121
84MP0002282_abnormal_trachea_morphology0.70048143
85MP0001542_abnormal_bone_strength0.69972941
86MP0002084_abnormal_developmental_patter0.69731466
87MP0001851_eye_inflammation0.69397085
88MP0002095_abnormal_skin_pigmentation0.69264959
89MP0003936_abnormal_reproductive_system0.68334779
90* MP0004197_abnormal_fetal_growth/weight/0.68004074
91MP0003755_abnormal_palate_morphology0.67817640
92MP0001730_embryonic_growth_arrest0.67201527
93MP0002877_abnormal_melanocyte_morpholog0.66615902
94MP0005499_abnormal_olfactory_system0.63349341
95MP0005394_taste/olfaction_phenotype0.63349341
96MP0005257_abnormal_intraocular_pressure0.60955594
97MP0004782_abnormal_surfactant_physiolog0.58215969
98MP0000490_abnormal_crypts_of0.57096543
99MP0002177_abnormal_outer_ear0.56617902
100MP0000465_gastrointestinal_hemorrhage0.55831023
101MP0001672_abnormal_embryogenesis/_devel0.55820794
102MP0005380_embryogenesis_phenotype0.55820794
103MP0002085_abnormal_embryonic_tissue0.55725501
104MP0001919_abnormal_reproductive_system0.54808788
105MP0003186_abnormal_redox_activity0.54122530
106MP0002132_abnormal_respiratory_system0.53665533
107MP0002295_abnormal_pulmonary_circulatio0.53512974
108MP0001697_abnormal_embryo_size0.53237487
109MP0002249_abnormal_larynx_morphology0.52606881
110MP0008058_abnormal_DNA_repair0.50934354
111MP0005666_abnormal_adipose_tissue0.50275167
112MP0005395_other_phenotype0.50035961
113MP0005083_abnormal_biliary_tract0.48877273
114* MP0002080_prenatal_lethality0.48824011
115MP0000432_abnormal_head_morphology0.48684526
116MP0002089_abnormal_postnatal_growth/wei0.47835941
117MP0000750_abnormal_muscle_regeneration0.47364138
118MP0001784_abnormal_fluid_regulation0.45769786
119MP0003638_abnormal_response/metabolism_0.45729109
120MP0005193_abnormal_anterior_eye0.44327942
121MP0001765_abnormal_ion_homeostasis0.44315780
122MP0001299_abnormal_eye_distance/0.44205561
123MP0003045_fibrosis0.43589405
124MP0005248_abnormal_Harderian_gland0.43320462
125MP0001881_abnormal_mammary_gland0.42017864
126MP0002896_abnormal_bone_mineralization0.40341481
127MP0000003_abnormal_adipose_tissue0.39027785
128MP0003091_abnormal_cell_migration0.36293556
129MP0005197_abnormal_uvea_morphology0.35900031
130MP0002233_abnormal_nose_morphology0.35645596
131MP0002697_abnormal_eye_size0.34369971
132MP0005621_abnormal_cell_physiology0.34212606
133MP0000462_abnormal_digestive_system0.34175250
134MP0001661_extended_life_span0.33682152
135MP0010368_abnormal_lymphatic_system0.30058489
136MP0000538_abnormal_urinary_bladder0.29606473
137MP0005375_adipose_tissue_phenotype0.29471647
138MP0000470_abnormal_stomach_morphology0.29290354
139MP0006138_congestive_heart_failure0.27796052
140MP0004043_abnormal_pH_regulation0.27499011
141MP0005377_hearing/vestibular/ear_phenot0.27297576
142MP0003878_abnormal_ear_physiology0.27297576
143MP0005330_cardiomyopathy0.26473881

Predicted human phenotypes

RankGene SetZ-score
1Thick nail (HP:0001805)7.42110447
2Alopecia of scalp (HP:0002293)6.53539192
3Atrophic scars (HP:0001075)5.97948616
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.69838109
5Congenital ichthyosiform erythroderma (HP:0007431)5.54658436
6Hypotrichosis (HP:0001006)5.48832653
7Ridged nail (HP:0001807)5.16170339
8Abnormality of cells of the erythroid lineage (HP:0012130)5.07280994
9Erythema (HP:0010783)5.06041921
10Lip pit (HP:0100267)4.97289031
11Parakeratosis (HP:0001036)4.90390636
12Reticulocytopenia (HP:0001896)4.87137391
13Woolly hair (HP:0002224)4.80067206
14Oral leukoplakia (HP:0002745)4.79568436
15Right ventricular cardiomyopathy (HP:0011663)4.39200485
16Abnormal number of erythroid precursors (HP:0012131)4.29789149
17Abnormal hair laboratory examination (HP:0003328)4.29484534
18Abnormality of secondary sexual hair (HP:0009888)4.14180480
19Abnormality of the axillary hair (HP:0100134)4.14180480
20Sparse eyelashes (HP:0000653)4.12602113
21Erythroderma (HP:0001019)3.79281624
22Concave nail (HP:0001598)3.78081472
23Abnormality of the salivary glands (HP:0010286)3.73950504
24Fragile nails (HP:0001808)3.70142237
25Plantar hyperkeratosis (HP:0007556)3.66072437
26Macrocytic anemia (HP:0001972)3.56625061
27Hypoplasia of dental enamel (HP:0006297)3.53525218
28Abnormal hemoglobin (HP:0011902)3.42138248
29Distal lower limb muscle weakness (HP:0009053)3.38171010
30Palmoplantar hyperkeratosis (HP:0000972)3.36205630
31Hypohidrosis (HP:0000966)3.36200425
32Palmar hyperkeratosis (HP:0010765)3.25932895
33Abnormal blistering of the skin (HP:0008066)3.22849577
34Stenosis of the external auditory canal (HP:0000402)3.14918257
35Dry hair (HP:0011359)3.13488060
36Trismus (HP:0000211)3.12898254
37Absent eyelashes (HP:0000561)3.08797810
38Sparse scalp hair (HP:0002209)3.08331631
39Abnormality of placental membranes (HP:0011409)3.07507738
40Amniotic constriction ring (HP:0009775)3.07507738
41Pallor (HP:0000980)3.04842842
42Popliteal pterygium (HP:0009756)2.99904714
43Septate vagina (HP:0001153)2.97847192
44Congenital, generalized hypertrichosis (HP:0004540)2.94945677
45Pili torti (HP:0003777)2.94236656
46Fragile skin (HP:0001030)2.92344459
47Abnormality of the fetal cardiovascular system (HP:0010948)2.92143785
48Abnormal umbilical cord blood vessels (HP:0011403)2.92143785
49Single umbilical artery (HP:0001195)2.92143785
50Nail dystrophy (HP:0008404)2.85615592
51Anonychia (HP:0001798)2.80343789
52Ankyloglossia (HP:0010296)2.76966059
53Premature ovarian failure (HP:0008209)2.74700448
54Fatigable weakness (HP:0003473)2.71065055
55Abnormality of the neuromuscular junction (HP:0003398)2.71065055
56Hypoplastic labia majora (HP:0000059)2.70588190
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66987296
58Aplasia cutis congenita (HP:0001057)2.65860062
59Breast hypoplasia (HP:0003187)2.64494320
60Ectropion (HP:0000656)2.62606851
61Areflexia of lower limbs (HP:0002522)2.53710947
62Corneal erosion (HP:0200020)2.52023274
63Abnormality of the umbilical cord (HP:0010881)2.49650953
64Hyperhidrosis (HP:0000975)2.45484357
65Increased IgE level (HP:0003212)2.45415018
66Abnormality of the labia majora (HP:0012881)2.43777821
67Conical tooth (HP:0000698)2.43406011
68Carious teeth (HP:0000670)2.43240171
69Abnormality of nail color (HP:0100643)2.41377743
70Onycholysis (HP:0001806)2.40596296
71Rough bone trabeculation (HP:0100670)2.35070230
72Natal tooth (HP:0000695)2.34664460
73Anhidrosis (HP:0000970)2.31524950
74Palmoplantar keratoderma (HP:0000982)2.29661683
75Acanthosis nigricans (HP:0000956)2.27806377
76Pterygium (HP:0001059)2.23484189
77Absent thumb (HP:0009777)2.23284577
78Conjunctival hamartoma (HP:0100780)2.23153844
79Absent radius (HP:0003974)2.22671226
80Dry skin (HP:0000958)2.21278512
81Curly hair (HP:0002212)2.19054114
82Hypodontia (HP:0000668)2.18476441
83Abnormality of the distal phalanges of the toes (HP:0010182)2.16802605
84Colon cancer (HP:0003003)2.16501976
85Ventricular tachycardia (HP:0004756)2.15476762
86Hyporeflexia of lower limbs (HP:0002600)2.15449902
87Abnormality of oral frenula (HP:0000190)2.14271139
88Milia (HP:0001056)2.09405676
89Abnormality of the fingernails (HP:0001231)2.08289209
90Aplasia involving forearm bones (HP:0009822)2.06913489
91Absent forearm bone (HP:0003953)2.06913489
92Dehydration (HP:0001944)2.03590731
93Fused cervical vertebrae (HP:0002949)1.99395191
94Laryngomalacia (HP:0001601)1.99259859
95Hypoplastic pelvis (HP:0008839)1.98486612
96Blepharitis (HP:0000498)1.95824119
97Partial duplication of thumb phalanx (HP:0009944)1.95511393
98Absent hair (HP:0002298)1.95217055
99Carpal bone hypoplasia (HP:0001498)1.92623882
10011 pairs of ribs (HP:0000878)1.91993076
101Asplenia (HP:0001746)1.91934633
102Hypoparathyroidism (HP:0000829)1.91602042
103Pruritus (HP:0000989)1.91207271
104Xerostomia (HP:0000217)1.91194899
105Follicular hyperkeratosis (HP:0007502)1.89761726
106Multifactorial inheritance (HP:0001426)1.89078013
107Oligodontia (HP:0000677)1.88905369
108Selective tooth agenesis (HP:0001592)1.88772666
109Fasciculations (HP:0002380)1.87678513
110Gangrene (HP:0100758)1.86881236
111Abnormal sex determination (HP:0012244)1.86554948
112Sex reversal (HP:0012245)1.86554948
113Advanced eruption of teeth (HP:0006288)1.86181769
114Brittle hair (HP:0002299)1.84730153
115Ureteral duplication (HP:0000073)1.84533066
116Split foot (HP:0001839)1.84210368
117Testicular atrophy (HP:0000029)1.83628146
118Skin ulcer (HP:0200042)1.83210883
119Upper limb muscle weakness (HP:0003484)1.82923778
120Nasolacrimal duct obstruction (HP:0000579)1.81554508
121Severe Myopia (HP:0011003)1.81192898
122Labial hypoplasia (HP:0000066)1.81181306
123Aplasia/hypoplasia of the uterus (HP:0008684)1.81034928
124Abnormality of permanent molar morphology (HP:0011071)1.80792848
125Abnormality of the dental root (HP:0006486)1.80792848
126Taurodontia (HP:0000679)1.80792848
127Multiple enchondromatosis (HP:0005701)1.78758840
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.78281619
129Abnormality of the labia (HP:0000058)1.77914485
130Down-sloping shoulders (HP:0200021)1.77538064
131Missing ribs (HP:0000921)1.75913931
132Amelogenesis imperfecta (HP:0000705)1.75618219
133Abnormal vertebral ossification (HP:0100569)1.73912812
134Pustule (HP:0200039)1.72729379
135Hypoplastic female external genitalia (HP:0012815)1.72332406
136Partial duplication of the phalanx of hand (HP:0009999)1.72103100
137Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.68989771
138Cheilitis (HP:0100825)1.68985122
139Corneal dystrophy (HP:0001131)1.66196790
140Epidermoid cyst (HP:0200040)1.66135849
141Abnormality of molar (HP:0011077)1.64051027
142Abnormality of molar morphology (HP:0011070)1.64051027
143Esophageal atresia (HP:0002032)1.63713627
144Squamous cell carcinoma (HP:0002860)1.62594134
145Short nail (HP:0001799)1.61680525
146Autoamputation (HP:0001218)1.59844253
147Slow-growing hair (HP:0002217)1.55149825
148Abnormality of hair growth rate (HP:0011363)1.55149825
149Abnormality of the dental pulp (HP:0006479)1.53734492
150Hypoplasia of the uterus (HP:0000013)1.52956212
151Hoarse voice (HP:0001609)1.51039248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.28966010
2MAPKAPK33.89929399
3MAP3K33.78737064
4MST43.66028374
5RPS6KB23.61045261
6WEE13.26630392
7MST1R3.26489034
8PIM22.99771531
9NME22.75427360
10TTK2.55037766
11RIPK12.51235640
12MAP3K92.47359745
13BUB12.41189720
14FER2.30842772
15NTRK12.28866166
16TGFBR12.22098148
17TESK12.19635303
18PTK22.06976954
19SIK12.04442725
20MET1.90767096
21NEK11.85754305
22MAP3K121.78934412
23STK101.73164393
24FLT31.70634687
25MAP3K111.69460834
26LATS21.65591224
27LRRK21.64031449
28LMTK21.57783632
29EPHB11.55204803
30BRAF1.50654491
31MAP3K61.49749906
32SMG11.44706756
33LIMK11.42021942
34SRPK11.38920173
35STK241.34090521
36TRIB31.28499323
37PRKCI1.27820119
38AURKA1.27450995
39CDK121.25975625
40PLK41.18987474
41PDGFRA1.18708848
42KSR21.17540467
43TRPM71.13475199
44STK38L1.12979158
45PBK1.06719743
46AURKB1.06061053
47NME11.04776849
48TLK11.03654364
49STK161.02826477
50PLK11.00301395
51BMX0.99890061
52MAP3K20.98660454
53CDK70.97446781
54TAOK20.95428077
55MAP2K20.94740128
56TSSK60.94206461
57RAF10.93731437
58EIF2AK20.93225398
59TESK20.89453701
60AKT30.89365121
61BRSK20.86278202
62GRK10.85756538
63PTK60.85443538
64MAP3K80.83380348
65MAP2K60.78654217
66EIF2AK10.78297852
67BLK0.77861227
68CHEK20.74128543
69RPS6KA40.72955833
70EPHB20.68821768
71NEK20.68722791
72VRK10.68308664
73STK380.66222456
74ERBB30.65853298
75MAPKAPK50.65820707
76TGFBR20.65715740
77CDK60.65017219
78MAP3K10.63911348
79PDK20.62184135
80PASK0.60973137
81ARAF0.60731044
82PLK30.60098830
83EIF2AK30.58683140
84BCKDK0.58666090
85ILK0.58377248
86MAPKAPK20.58362273
87PAK10.57260787
88TYRO30.55951997
89MAP3K130.55741082
90MOS0.55413991
91ERN10.53887320
92TAOK10.52370554
93ZAK0.52100537
94PIM10.51619978
95CSNK1E0.51486316
96PDK40.51182319
97PDK30.51182319
98RPS6KA20.50787728
99LATS10.50369805
100PKN20.50286504
101ROCK20.50134568
102BCR0.49700872
103MAP3K50.49251332
104PIK3CG0.48401451
105STK30.48153249
106DDR20.47783670
107CSNK2A20.47669808
108CDK40.46727227
109PDGFRB0.46521285
110DYRK30.46333818
111IKBKB0.45312426
112PAK40.45163454
113MYLK0.45006081
114DYRK20.43440903
115EEF2K0.43342247
116PRKD20.41595304
117CSNK2A10.40240382
118FGFR40.40003849
119IRAK30.38566716
120PRPF4B0.37841731
121MAP2K10.37678765
122DYRK1B0.37661843
123RET0.37582943
124CHEK10.37399560
125NEK60.34776608
126NTRK20.34320568
127GRK70.33412677
128CDK20.32973858
129PNCK0.32762582
130FGFR10.31921526
131CSNK1D0.31829815
132GRK50.30136227
133ABL20.29814534
134ERBB20.27840565
135MTOR0.27545378
136CAMK2G0.27271916
137MAPK150.27270706
138JAK30.26470146
139TTN0.26059936
140CSF1R0.23525681
141KSR10.21505204
142RPS6KA10.20884984
143FGR0.20696125
144CDC42BPA0.20080685
145PRKCD0.19433412
146ADRBK10.19050635
147ZAP700.17977155
148IGF1R0.16908932
149ROCK10.16212201
150MATK0.14127753
151PRKG20.13381525
152SRC0.13087901

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.94093083
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.48712754
3Proteasome_Homo sapiens_hsa030503.97774082
4Arachidonic acid metabolism_Homo sapiens_hsa005902.83579934
5RNA polymerase_Homo sapiens_hsa030202.82982849
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76103699
7Sphingolipid metabolism_Homo sapiens_hsa006002.53163647
8Linoleic acid metabolism_Homo sapiens_hsa005912.45004309
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.42421195
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24491375
11Amoebiasis_Homo sapiens_hsa051462.23283434
12Focal adhesion_Homo sapiens_hsa045102.19533659
13Steroid biosynthesis_Homo sapiens_hsa001002.14571642
14Mismatch repair_Homo sapiens_hsa034302.14233890
15p53 signaling pathway_Homo sapiens_hsa041152.08091176
16RNA transport_Homo sapiens_hsa030132.08043807
17DNA replication_Homo sapiens_hsa030302.01937543
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95697487
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.92755633
20Spliceosome_Homo sapiens_hsa030401.74686527
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70891455
22Nucleotide excision repair_Homo sapiens_hsa034201.63427064
23ErbB signaling pathway_Homo sapiens_hsa040121.59817379
24Glutathione metabolism_Homo sapiens_hsa004801.57850587
25Phenylalanine metabolism_Homo sapiens_hsa003601.52927905
26Sulfur metabolism_Homo sapiens_hsa009201.52805008
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51452894
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.48037189
29Pyrimidine metabolism_Homo sapiens_hsa002401.47888012
30Folate biosynthesis_Homo sapiens_hsa007901.47722059
31Basal cell carcinoma_Homo sapiens_hsa052171.39343907
32Homologous recombination_Homo sapiens_hsa034401.39107257
33One carbon pool by folate_Homo sapiens_hsa006701.33924224
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33688967
35Toxoplasmosis_Homo sapiens_hsa051451.32276123
36Hippo signaling pathway_Homo sapiens_hsa043901.30248589
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27426383
38Shigellosis_Homo sapiens_hsa051311.25767862
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22989623
40Notch signaling pathway_Homo sapiens_hsa043301.22394769
41Fatty acid elongation_Homo sapiens_hsa000621.22325748
42Retinol metabolism_Homo sapiens_hsa008301.20426841
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19663845
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19616303
45Pancreatic cancer_Homo sapiens_hsa052121.18534956
46Chronic myeloid leukemia_Homo sapiens_hsa052201.18483647
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17664518
48Cell cycle_Homo sapiens_hsa041101.17176250
49Base excision repair_Homo sapiens_hsa034101.16243967
50Hedgehog signaling pathway_Homo sapiens_hsa043401.08649777
51Tight junction_Homo sapiens_hsa045301.07122772
52Ether lipid metabolism_Homo sapiens_hsa005651.06236534
53Histidine metabolism_Homo sapiens_hsa003401.02835623
54Endocytosis_Homo sapiens_hsa041441.02699258
55GnRH signaling pathway_Homo sapiens_hsa049121.01367307
56Glioma_Homo sapiens_hsa052141.01325293
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98062868
58Basal transcription factors_Homo sapiens_hsa030220.97759157
59Renal cell carcinoma_Homo sapiens_hsa052110.95779231
60Acute myeloid leukemia_Homo sapiens_hsa052210.94439587
61Chemical carcinogenesis_Homo sapiens_hsa052040.93016942
62Salmonella infection_Homo sapiens_hsa051320.91513169
63Adherens junction_Homo sapiens_hsa045200.90979287
64Fanconi anemia pathway_Homo sapiens_hsa034600.89687319
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87284237
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86234472
67Insulin signaling pathway_Homo sapiens_hsa049100.82401004
68Epstein-Barr virus infection_Homo sapiens_hsa051690.82387839
69Endometrial cancer_Homo sapiens_hsa052130.82322117
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80202217
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79687748
72Hepatitis C_Homo sapiens_hsa051600.78402705
73Dilated cardiomyopathy_Homo sapiens_hsa054140.77765624
74Regulation of autophagy_Homo sapiens_hsa041400.77732229
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77135500
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74410462
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74165134
78Inositol phosphate metabolism_Homo sapiens_hsa005620.73897538
79Pentose phosphate pathway_Homo sapiens_hsa000300.73741211
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73375347
81TGF-beta signaling pathway_Homo sapiens_hsa043500.73243941
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72318871
83Fructose and mannose metabolism_Homo sapiens_hsa000510.72079164
84Tyrosine metabolism_Homo sapiens_hsa003500.72054023
85Caffeine metabolism_Homo sapiens_hsa002320.71127883
86Prion diseases_Homo sapiens_hsa050200.70610463
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69390937
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68448084
89Oxidative phosphorylation_Homo sapiens_hsa001900.67629304
90MicroRNAs in cancer_Homo sapiens_hsa052060.67386290
91ECM-receptor interaction_Homo sapiens_hsa045120.65052119
92Bladder cancer_Homo sapiens_hsa052190.64030756
93N-Glycan biosynthesis_Homo sapiens_hsa005100.60630559
94RNA degradation_Homo sapiens_hsa030180.58091528
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57386448
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.54610965
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54394954
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50798038
99Circadian rhythm_Homo sapiens_hsa047100.50733342
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50519458
101Vibrio cholerae infection_Homo sapiens_hsa051100.49949994
102Huntingtons disease_Homo sapiens_hsa050160.49885398
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48529700
104Thyroid cancer_Homo sapiens_hsa052160.47843361
105Non-small cell lung cancer_Homo sapiens_hsa052230.47163794
106Proteoglycans in cancer_Homo sapiens_hsa052050.47075272
107beta-Alanine metabolism_Homo sapiens_hsa004100.46265895
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45410795
109Fat digestion and absorption_Homo sapiens_hsa049750.44783557
110Purine metabolism_Homo sapiens_hsa002300.42974016
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42831376
112HTLV-I infection_Homo sapiens_hsa051660.42026474
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.41711262
114Estrogen signaling pathway_Homo sapiens_hsa049150.40632467
115Dorso-ventral axis formation_Homo sapiens_hsa043200.39872274
116Metabolic pathways_Homo sapiens_hsa011000.39257638
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38535763
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38365456
119Arginine biosynthesis_Homo sapiens_hsa002200.38313616
120Renin secretion_Homo sapiens_hsa049240.38126608
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.37247834
122mRNA surveillance pathway_Homo sapiens_hsa030150.36381512
123Wnt signaling pathway_Homo sapiens_hsa043100.36100817
124Choline metabolism in cancer_Homo sapiens_hsa052310.35765499
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34907370
126Melanogenesis_Homo sapiens_hsa049160.34663398
127Glycerolipid metabolism_Homo sapiens_hsa005610.34261096
128Fatty acid biosynthesis_Homo sapiens_hsa000610.34211732
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.34026243
130Rap1 signaling pathway_Homo sapiens_hsa040150.33962308
131Non-homologous end-joining_Homo sapiens_hsa034500.33755183
132Ovarian steroidogenesis_Homo sapiens_hsa049130.33155721
133VEGF signaling pathway_Homo sapiens_hsa043700.32800868
134Prostate cancer_Homo sapiens_hsa052150.32614614
135Oocyte meiosis_Homo sapiens_hsa041140.32216160
136Small cell lung cancer_Homo sapiens_hsa052220.32090967
137Parkinsons disease_Homo sapiens_hsa050120.30947435
138Legionellosis_Homo sapiens_hsa051340.30141514
139Galactose metabolism_Homo sapiens_hsa000520.29432716
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29079592
141Mineral absorption_Homo sapiens_hsa049780.27620262
142Pathways in cancer_Homo sapiens_hsa052000.26242697
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26018602
144Viral carcinogenesis_Homo sapiens_hsa052030.22575244
145Other glycan degradation_Homo sapiens_hsa005110.20943341
146Carbon metabolism_Homo sapiens_hsa012000.17026329
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16300549
148Biosynthesis of amino acids_Homo sapiens_hsa012300.14396196
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.13546700
150Arginine and proline metabolism_Homo sapiens_hsa003300.12369932
151Axon guidance_Homo sapiens_hsa043600.12330568
152Melanoma_Homo sapiens_hsa052180.10286823
153Apoptosis_Homo sapiens_hsa042100.10253683
154Sulfur relay system_Homo sapiens_hsa041220.09682751
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08509748
156Vitamin digestion and absorption_Homo sapiens_hsa049770.08451437

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