GJC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.15894766
2ensheathment of neurons (GO:0007272)7.20573937
3axon ensheathment (GO:0008366)7.20573937
4myelination (GO:0042552)7.18360801
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.44048855
6long-chain fatty acid biosynthetic process (GO:0042759)5.99483793
7glutamate secretion (GO:0014047)5.98204530
8synaptic vesicle maturation (GO:0016188)5.65930917
9negative regulation of neurotransmitter secretion (GO:0046929)5.32028881
10synaptic vesicle exocytosis (GO:0016079)5.31998198
11cholesterol biosynthetic process (GO:0006695)5.16925214
12myelin maintenance (GO:0043217)5.08446813
13cellular potassium ion homeostasis (GO:0030007)4.98029958
14sodium ion export (GO:0071436)4.96660696
15regulation of short-term neuronal synaptic plasticity (GO:0048172)4.92126758
16oligodendrocyte differentiation (GO:0048709)4.77683991
17negative regulation of neurotransmitter transport (GO:0051589)4.71996689
18glycerophospholipid catabolic process (GO:0046475)4.68122100
19creatine metabolic process (GO:0006600)4.66970020
20regulation of synaptic vesicle exocytosis (GO:2000300)4.57590033
21positive regulation of synapse maturation (GO:0090129)4.56018963
22sterol biosynthetic process (GO:0016126)4.52494563
23regulation of collateral sprouting (GO:0048670)4.40930158
24substantia nigra development (GO:0021762)4.34732739
25establishment of mitochondrion localization (GO:0051654)4.32604925
26negative regulation of protein localization to cell surface (GO:2000009)4.32541535
27peptidyl-tyrosine autophosphorylation (GO:0038083)4.27751821
28eye photoreceptor cell differentiation (GO:0001754)4.24203822
29photoreceptor cell differentiation (GO:0046530)4.24203822
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.20237253
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17516525
32astrocyte development (GO:0014002)4.13232727
33presynaptic membrane organization (GO:0097090)4.11108727
34cytoskeletal anchoring at plasma membrane (GO:0007016)4.08224958
35G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.06362765
36apical protein localization (GO:0045176)4.04797403
37L-amino acid import (GO:0043092)4.04563180
38asymmetric protein localization (GO:0008105)3.98711401
39amyloid precursor protein metabolic process (GO:0042982)3.97762317
40regulation of neuronal synaptic plasticity (GO:0048168)3.94380713
41neurotransmitter secretion (GO:0007269)3.93002487
42response to methylmercury (GO:0051597)3.91377017
43response to redox state (GO:0051775)3.88537475
44presynaptic membrane assembly (GO:0097105)3.87719352
45virion attachment to host cell (GO:0019062)3.87072538
46adhesion of symbiont to host cell (GO:0044650)3.87072538
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.86669376
48negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.84710111
49positive regulation of oligodendrocyte differentiation (GO:0048714)3.84487187
50regulation of synaptic vesicle transport (GO:1902803)3.83162085
51isoprenoid biosynthetic process (GO:0008299)3.80876375
52import into cell (GO:0098657)3.78415200
53peripheral nervous system axon ensheathment (GO:0032292)3.77695371
54myelination in peripheral nervous system (GO:0022011)3.77695371
55potassium ion homeostasis (GO:0055075)3.75198873
56vocalization behavior (GO:0071625)3.72553328
57response to lipoprotein particle (GO:0055094)3.70633517
58fatty-acyl-CoA biosynthetic process (GO:0046949)3.67476774
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62188252
60regulation of synapse maturation (GO:0090128)3.47424635
61negative regulation of dendrite morphogenesis (GO:0050774)3.46316620
62regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41671602
63fatty-acyl-CoA metabolic process (GO:0035337)3.39873141
64protein palmitoylation (GO:0018345)3.39403577
65positive regulation of dendritic spine development (GO:0060999)3.38051745
66adult walking behavior (GO:0007628)3.36275158
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34723272
68acidic amino acid transport (GO:0015800)3.34099889
69membrane tubulation (GO:0097320)3.32420286
70negative regulation of axonogenesis (GO:0050771)3.32098250
71transmission of nerve impulse (GO:0019226)3.30741497
72regulation of cholesterol biosynthetic process (GO:0045540)3.28159388
73magnesium ion transport (GO:0015693)3.26982062
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.25886960
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25577628
76regulation of ARF protein signal transduction (GO:0032012)3.24905115
77regulation of synaptic plasticity (GO:0048167)3.24475496
78glycosylceramide metabolic process (GO:0006677)3.23455209
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.21157034
80regulation of synapse structural plasticity (GO:0051823)3.19218236
81potassium ion import (GO:0010107)3.19149285
82locomotory exploration behavior (GO:0035641)3.19021204
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.17345376
84very long-chain fatty acid metabolic process (GO:0000038)3.15679201
85negative regulation of inclusion body assembly (GO:0090084)3.14666788
86neuromuscular process controlling balance (GO:0050885)3.13498363
87neuronal ion channel clustering (GO:0045161)3.13391575
88neurotransmitter transport (GO:0006836)3.13037585
89L-glutamate transport (GO:0015813)3.10081964
90negative regulation of execution phase of apoptosis (GO:1900118)3.09650219
91layer formation in cerebral cortex (GO:0021819)3.08362182
92neuron remodeling (GO:0016322)3.07653114
93cellular response to epinephrine stimulus (GO:0071872)3.07286782
94positive regulation of action potential (GO:0045760)3.06401341
95amyloid precursor protein catabolic process (GO:0042987)3.06112836
96regulation of glutamate receptor signaling pathway (GO:1900449)3.04324858
97peripheral nervous system development (GO:0007422)3.02790282
98regulation of ARF GTPase activity (GO:0032312)3.00351827
99neuron cell-cell adhesion (GO:0007158)2.99250836
100axon development (GO:0061564)2.98173120
101limb bud formation (GO:0060174)2.97294708
102acyl-CoA biosynthetic process (GO:0071616)2.96942649
103thioester biosynthetic process (GO:0035384)2.96942649
104synaptic vesicle endocytosis (GO:0048488)2.94375382
105GPI anchor biosynthetic process (GO:0006506)2.93373788
106peptidyl-cysteine modification (GO:0018198)2.92711677
107cerebral cortex radially oriented cell migration (GO:0021799)2.91984638
108GPI anchor metabolic process (GO:0006505)2.89822426
109nerve growth factor signaling pathway (GO:0038180)2.89595912
110neural nucleus development (GO:0048857)2.89269135
111cell communication by electrical coupling (GO:0010644)2.88914135
112amino acid import (GO:0043090)2.87390800
113negative regulation of JUN kinase activity (GO:0043508)2.86612541
114regulation of voltage-gated calcium channel activity (GO:1901385)2.86140708
115nucleotide transmembrane transport (GO:1901679)2.85650675
116neuronal action potential propagation (GO:0019227)2.85115718
117regulation of neurotransmitter levels (GO:0001505)2.84332892
118cellular sodium ion homeostasis (GO:0006883)2.82511245
119dicarboxylic acid transport (GO:0006835)2.82065647
120adhesion of symbiont to host (GO:0044406)2.81897316
121negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81563845
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81135188
123regulation of lipoprotein metabolic process (GO:0050746)2.80588998
124leukocyte migration involved in inflammatory response (GO:0002523)2.79417008
125negative regulation of axon extension (GO:0030517)2.78210741
126glial cell development (GO:0021782)2.76583368
127postsynaptic membrane organization (GO:0001941)2.76094115
128synaptic transmission, glutamatergic (GO:0035249)2.75529931
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.73741229
130positive regulation of glial cell differentiation (GO:0045687)2.72957456
131response to epinephrine (GO:0071871)2.72824126
132neurotransmitter-gated ion channel clustering (GO:0072578)2.72460311
133positive regulation of neurotransmitter transport (GO:0051590)2.71338927
134regulation of neurotransmitter secretion (GO:0046928)2.70269176
135dendritic spine organization (GO:0097061)2.68637218
136dopamine receptor signaling pathway (GO:0007212)2.68486679
137regulation of dendritic spine morphogenesis (GO:0061001)2.67837284
138positive regulation of dendrite development (GO:1900006)2.67531122
139regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67497207
140preassembly of GPI anchor in ER membrane (GO:0016254)2.65654856
141activation of protein kinase A activity (GO:0034199)2.64225419
142positive regulation of membrane potential (GO:0045838)2.63638054
143exploration behavior (GO:0035640)2.63591156
144long-term memory (GO:0007616)2.63260760
145adenosine receptor signaling pathway (GO:0001973)2.63122699
146iron coordination entity transport (GO:1901678)2.60634473
147cerebellar granule cell differentiation (GO:0021707)2.60475355
148cellular response to monoamine stimulus (GO:0071868)2.60273293
149cellular response to catecholamine stimulus (GO:0071870)2.60273293
150cellular response to hepatocyte growth factor stimulus (GO:0035729)2.60178185
151response to hepatocyte growth factor (GO:0035728)2.60178185
152regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.58927926
153cell migration in hindbrain (GO:0021535)2.58532351
154positive regulation of cellular amine metabolic process (GO:0033240)2.58416878
155positive regulation of gliogenesis (GO:0014015)2.58212410
156positive regulation of neurotransmitter secretion (GO:0001956)2.57917742
157activation of Rac GTPase activity (GO:0032863)2.57890268
158neuron-neuron synaptic transmission (GO:0007270)2.56866621
159glial cell differentiation (GO:0010001)2.56786970
160protein targeting to plasma membrane (GO:0072661)2.55562128
161enteric nervous system development (GO:0048484)2.55031288
162organ growth (GO:0035265)2.53487163
163interleukin-6-mediated signaling pathway (GO:0070102)2.52985297
164cell volume homeostasis (GO:0006884)2.51823628
165long term synaptic depression (GO:0060292)2.51139104
166neurotransmitter uptake (GO:0001504)2.50474754
167protein localization to synapse (GO:0035418)2.50200921
168heme transport (GO:0015886)2.48774260
169regulation of dendritic spine development (GO:0060998)2.47848964
170membrane assembly (GO:0071709)2.47410055
171negative regulation of macroautophagy (GO:0016242)2.47402681
172ceramide biosynthetic process (GO:0046513)2.46765653
173detection of temperature stimulus involved in sensory perception (GO:0050961)2.46081229
174detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.46081229
175long-term synaptic potentiation (GO:0060291)2.45902137
176regulation of vesicle fusion (GO:0031338)2.45565373
177regulation of sensory perception (GO:0051931)2.44526872
178regulation of sensory perception of pain (GO:0051930)2.44526872
179gamma-aminobutyric acid signaling pathway (GO:0007214)2.43102286
180regulation of neurotransmitter transport (GO:0051588)2.41920944
181regulation of inclusion body assembly (GO:0090083)2.40059581
182positive regulation of Rap GTPase activity (GO:0032854)2.39838292
183regulation of synaptic transmission (GO:0050804)2.37865440
184central nervous system myelination (GO:0022010)11.5431574
185axon ensheathment in central nervous system (GO:0032291)11.5431574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.51589423
2* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.23511022
3GBX2_23144817_ChIP-Seq_PC3_Human3.22802827
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.01582035
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83143540
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.81046223
7* LXR_22292898_ChIP-Seq_THP-1_Human2.75998193
8KDM2B_26808549_Chip-Seq_K562_Human2.49502479
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35270663
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.34993027
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34415132
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34106496
13TAF15_26573619_Chip-Seq_HEK293_Human2.28065979
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.27701783
15EZH2_22144423_ChIP-Seq_EOC_Human2.23018418
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19155989
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.17417719
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.17099439
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15106306
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11907295
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08914227
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07780903
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.05591610
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05371627
25DNAJC2_21179169_ChIP-ChIP_NT2_Human2.01611785
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01075439
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01075439
28EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.00886410
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98799697
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96612635
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95617126
32* EZH2_27304074_Chip-Seq_ESCs_Mouse1.95126058
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.88290976
34* EZH2_27294783_Chip-Seq_ESCs_Mouse1.87295297
35CTCF_27219007_Chip-Seq_Bcells_Human1.86543155
36KDM2B_26808549_Chip-Seq_DND41_Human1.85386904
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85130573
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84280668
39AR_21572438_ChIP-Seq_LNCaP_Human1.83934453
40VDR_22108803_ChIP-Seq_LS180_Human1.81227215
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.80371722
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79210620
43DROSHA_22980978_ChIP-Seq_HELA_Human1.72416038
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71924163
45SMC4_20622854_ChIP-Seq_HELA_Human1.70523755
46ER_23166858_ChIP-Seq_MCF-7_Human1.68344023
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67852184
48P68_20966046_ChIP-Seq_HELA_Human1.67137832
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65028544
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65018395
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64456528
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.63787976
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61340109
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60413327
55TET1_21490601_ChIP-Seq_MESCs_Mouse1.59714185
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58605132
57* RNF2_27304074_Chip-Seq_ESCs_Mouse1.57468482
58TCF7_22412390_ChIP-Seq_EML_Mouse1.56737880
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56262191
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56009127
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.51879493
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49596504
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46615541
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46442747
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.46334686
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.46036488
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.43017828
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42303976
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.41941801
70* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41546153
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41524948
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.41140349
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40555368
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40109464
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40031566
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38161968
77ZNF263_19887448_ChIP-Seq_K562_Human1.37662597
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.35837099
79CREB1_26743006_Chip-Seq_LNCaP_Human1.35396349
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34896980
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31604310
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.31228503
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30680449
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30260584
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29327074
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26732725
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.26289364
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26060212
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23707012
90REST_21632747_ChIP-Seq_MESCs_Mouse1.22693632
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21738790
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21215375
93OCT4_19829295_ChIP-Seq_ESCs_Human1.20999296
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18685272
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.17711770
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16895230
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16851586
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16840768
99P300_19829295_ChIP-Seq_ESCs_Human1.16272826
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15931493
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15931493
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15872020
103FUS_26573619_Chip-Seq_HEK293_Human1.15724963
104SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14571203
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13084487
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12426992
107VDR_21846776_ChIP-Seq_THP-1_Human1.11520092
108EOMES_21245162_ChIP-Seq_HESCs_Human1.11260406
109TP63_22573176_ChIP-Seq_HFKS_Human1.10917549
110* TP53_23651856_ChIP-Seq_MEFs_Mouse1.10833817
111CTCF_20526341_ChIP-Seq_ESCs_Human1.10412532
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10242527
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.08425756
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07860467
115* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07552982
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.06891534
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06794351
118REST_18959480_ChIP-ChIP_MESCs_Mouse1.06709092
119NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06596875
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.06293989
121HTT_18923047_ChIP-ChIP_STHdh_Human1.05891174
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04962062
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04650955
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04530711
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.04416163
126* STAT3_23295773_ChIP-Seq_U87_Human1.03298992
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01908607
128* BCOR_27268052_Chip-Seq_Bcells_Human1.01208968
129* SA1_27219007_Chip-Seq_Bcells_Human1.00788792
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99727080
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.99471523
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99040536
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98710931
134KLF4_19829295_ChIP-Seq_ESCs_Human0.98459478
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.98064157
136TCF4_23295773_ChIP-Seq_U87_Human0.97305914
137JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97052324
138TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97009763
139TP53_22127205_ChIP-Seq_IMR90_Human0.96876239
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95845908
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95572464
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.94518244
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94072892
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.93977356
145PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93975332
146RNF2_27304074_Chip-Seq_NSC_Mouse0.93793363
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93492449
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93032506
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92596450
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90853832
151NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90832407
152P300_18555785_Chip-Seq_ESCs_Mouse0.90789391
153SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90783732
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90224444
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89321099
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89170401
157RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88945389
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88701513
159SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88473358
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.88420019
161SMAD4_21799915_ChIP-Seq_A2780_Human0.88299493
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.88082027
163NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88035267
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.87301253
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86919627
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86752906
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85426191
168ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85310622
169NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84966784
170NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84815802
171OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84689714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.49638669
2MP0003880_abnormal_central_pattern4.08004768
3MP0003950_abnormal_plasma_membrane3.82084320
4MP0004270_analgesia3.50348826
5MP0003690_abnormal_glial_cell3.43995660
6MP0003329_amyloid_beta_deposits2.84325957
7MP0001529_abnormal_vocalization2.80859359
8MP0004885_abnormal_endolymph2.73621142
9MP0004742_abnormal_vestibular_system2.61574256
10MP0005171_absent_coat_pigmentation2.59169387
11MP0002272_abnormal_nervous_system2.58743392
12MP0001905_abnormal_dopamine_level2.51013602
13MP0001486_abnormal_startle_reflex2.46298236
14MP0003634_abnormal_glial_cell2.45661394
15MP0004859_abnormal_synaptic_plasticity2.43808500
16MP0003879_abnormal_hair_cell2.37624828
17MP0003136_yellow_coat_color2.28965879
18MP0002064_seizures2.26940025
19MP0004142_abnormal_muscle_tone2.25280039
20MP0005409_darkened_coat_color2.24149435
21MP0009780_abnormal_chondrocyte_physiolo2.23143633
22MP0001485_abnormal_pinna_reflex2.22839159
23MP0000778_abnormal_nervous_system2.18947953
24MP0003705_abnormal_hypodermis_morpholog2.15637498
25MP0003632_abnormal_nervous_system1.99501847
26MP0005451_abnormal_body_composition1.98086369
27MP0005410_abnormal_fertilization1.85410120
28MP0000462_abnormal_digestive_system1.85000692
29MP0005423_abnormal_somatic_nervous1.83042118
30MP0009046_muscle_twitch1.82932182
31* MP0002229_neurodegeneration1.81184061
32MP0010678_abnormal_skin_adnexa1.77285122
33MP0003635_abnormal_synaptic_transmissio1.76956985
34MP0009745_abnormal_behavioral_response1.76732936
35MP0000383_abnormal_hair_follicle1.72998417
36MP0002734_abnormal_mechanical_nocicepti1.72411377
37MP0003123_paternal_imprinting1.68095082
38MP0010234_abnormal_vibrissa_follicle1.58111635
39MP0004381_abnormal_hair_follicle1.53829180
40MP0000955_abnormal_spinal_cord1.53508020
41MP0004043_abnormal_pH_regulation1.52155887
42MP0000604_amyloidosis1.47534809
43MP0003806_abnormal_nucleotide_metabolis1.46726568
44MP0003631_nervous_system_phenotype1.44515954
45MP0004134_abnormal_chest_morphology1.44288417
46MP0003195_calcinosis1.43684519
47MP0005167_abnormal_blood-brain_barrier1.41027595
48MP0002882_abnormal_neuron_morphology1.40624319
49MP0001440_abnormal_grooming_behavior1.37749078
50MP0005551_abnormal_eye_electrophysiolog1.35866550
51MP0002572_abnormal_emotion/affect_behav1.33324972
52MP0002249_abnormal_larynx_morphology1.32321380
53MP0002066_abnormal_motor_capabilities/c1.29520970
54MP0008569_lethality_at_weaning1.26407346
55MP0002063_abnormal_learning/memory/cond1.25780701
56MP0004147_increased_porphyrin_level1.23168064
57MP0003172_abnormal_lysosome_physiology1.23000468
58MP0005386_behavior/neurological_phenoty1.22907179
59MP0004924_abnormal_behavior1.22907179
60MP0001346_abnormal_lacrimal_gland1.22261946
61MP0000747_muscle_weakness1.22019668
62MP0008874_decreased_physiological_sensi1.21817738
63MP0001958_emphysema1.21382919
64MP0003633_abnormal_nervous_system1.18544555
65MP0002067_abnormal_sensory_capabilities1.16786079
66MP0001963_abnormal_hearing_physiology1.14852841
67MP0001970_abnormal_pain_threshold1.14750295
68MP0002752_abnormal_somatic_nervous1.14279520
69MP0005623_abnormal_meninges_morphology1.10899769
70MP0008260_abnormal_autophagy1.10792035
71MP0003075_altered_response_to1.09367943
72MP0000647_abnormal_sebaceous_gland1.01978897
73MP0002733_abnormal_thermal_nociception1.00239132
74MP0001299_abnormal_eye_distance/0.98431572
75MP0003283_abnormal_digestive_organ0.97767634
76MP0005408_hypopigmentation0.94565184
77MP0005670_abnormal_white_adipose0.94405618
78MP0001851_eye_inflammation0.93674880
79MP0005195_abnormal_posterior_eye0.93321676
80MP0000566_synostosis0.92126618
81MP0002295_abnormal_pulmonary_circulatio0.91982460
82MP0003938_abnormal_ear_development0.91806762
83MP0005076_abnormal_cell_differentiation0.91102178
84MP0005058_abnormal_lysosome_morphology0.90966571
85MP0000003_abnormal_adipose_tissue0.90575089
86MP0002089_abnormal_postnatal_growth/wei0.89445646
87MP0000751_myopathy0.87160722
88MP0001984_abnormal_olfaction0.86560636
89MP0001177_atelectasis0.85518644
90MP0001661_extended_life_span0.85389455
91MP0003453_abnormal_keratinocyte_physiol0.85180922
92MP0000762_abnormal_tongue_morphology0.80372432
93MP0003787_abnormal_imprinting0.79954737
94* MP0002152_abnormal_brain_morphology0.79043825
95MP0004145_abnormal_muscle_electrophysio0.78754491
96MP0008438_abnormal_cutaneous_collagen0.78452455
97MP0001348_abnormal_lacrimal_gland0.78110427
98MP0002822_catalepsy0.77624417
99MP0003937_abnormal_limbs/digits/tail_de0.76429756
100MP0001968_abnormal_touch/_nociception0.75676579
101MP0003279_aneurysm0.75484037
102MP0000026_abnormal_inner_ear0.74698594
103MP0002090_abnormal_vision0.74048523
104MP0002735_abnormal_chemical_nociception0.72175618
105MP0001849_ear_inflammation0.72067674
106MP0005253_abnormal_eye_physiology0.71693926
107MP0000579_abnormal_nail_morphology0.71278665
108MP0000467_abnormal_esophagus_morphology0.70517887
109MP0005275_abnormal_skin_tensile0.70180456
110MP0006072_abnormal_retinal_apoptosis0.69707699
111MP0004858_abnormal_nervous_system0.69119375
112MP0005375_adipose_tissue_phenotype0.68294771
113MP0003191_abnormal_cellular_cholesterol0.66617184
114MP0001501_abnormal_sleep_pattern0.66118935
115MP0001664_abnormal_digestion0.65677760
116MP0000678_abnormal_parathyroid_gland0.64961760
117MP0004185_abnormal_adipocyte_glucose0.64713084
118MP0004036_abnormal_muscle_relaxation0.64004387
119MP0000681_abnormal_thyroid_gland0.63342234
120MP0004130_abnormal_muscle_cell0.63312874
121MP0005595_abnormal_vascular_smooth0.63146947
122MP0002184_abnormal_innervation0.62153422
123MP0002909_abnormal_adrenal_gland0.62092895
124MP0005666_abnormal_adipose_tissue0.62035712
125MP0004811_abnormal_neuron_physiology0.62017098
126MP0010771_integument_phenotype0.61951661
127MP0004510_myositis0.61060812
128MP0001765_abnormal_ion_homeostasis0.60952507
129MP0001502_abnormal_circadian_rhythm0.60658280
130MP0009840_abnormal_foam_cell0.59141507
131MP0005535_abnormal_body_temperature0.59115503
132MP0006082_CNS_inflammation0.59068510
133MP0002060_abnormal_skin_morphology0.58987023
134MP0002736_abnormal_nociception_after0.57720165
135MP0003137_abnormal_impulse_conducting0.56204600
136MP0001727_abnormal_embryo_implantation0.55015451
137MP0001340_abnormal_eyelid_morphology0.54809133
138MP0002557_abnormal_social/conspecific_i0.54692323

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.68188997
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.68188997
3Neurofibrillary tangles (HP:0002185)6.60528857
4Parakeratosis (HP:0001036)5.50165015
5Abnormality of the corticospinal tract (HP:0002492)4.97770254
6Peripheral hypomyelination (HP:0007182)4.83908097
7Cerebral inclusion bodies (HP:0100314)4.76178050
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.35583940
9Supranuclear gaze palsy (HP:0000605)4.09640201
10Onion bulb formation (HP:0003383)4.05446300
11Abnormality of binocular vision (HP:0011514)3.92471838
12Diplopia (HP:0000651)3.92471838
13Obstructive sleep apnea (HP:0002870)3.77151695
14Focal motor seizures (HP:0011153)3.65573410
15Insomnia (HP:0100785)3.59092276
16Alacrima (HP:0000522)3.50954777
17Abnormal auditory evoked potentials (HP:0006958)3.48862415
18Akinesia (HP:0002304)3.34854258
19Upper limb amyotrophy (HP:0009129)3.28163189
20Distal upper limb amyotrophy (HP:0007149)3.28163189
21Increased serum pyruvate (HP:0003542)3.27291697
22Abnormality of glycolysis (HP:0004366)3.27291697
23Hyperacusis (HP:0010780)3.20934888
24Annular pancreas (HP:0001734)3.18190763
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.17380933
26Focal seizures (HP:0007359)3.16116111
27Termporal pattern (HP:0011008)3.15415224
28Insidious onset (HP:0003587)3.15415224
29Epileptic encephalopathy (HP:0200134)3.14044341
30Congenital ichthyosiform erythroderma (HP:0007431)3.10445246
31Visual hallucinations (HP:0002367)3.08737240
32Myokymia (HP:0002411)3.02593190
33Scanning speech (HP:0002168)3.00777288
34* Spastic gait (HP:0002064)2.98028167
35Retinal dysplasia (HP:0007973)2.92571706
36Ankle clonus (HP:0011448)2.87006458
37Lower limb amyotrophy (HP:0007210)2.81992441
38* Dysmetria (HP:0001310)2.80469075
39Cerebral hemorrhage (HP:0001342)2.72028465
40Decreased lacrimation (HP:0000633)2.68406703
41Clumsiness (HP:0002312)2.65462081
42Anteriorly placed anus (HP:0001545)2.64517877
43Stridor (HP:0010307)2.64125308
44Bronchomalacia (HP:0002780)2.63982859
45Premature skin wrinkling (HP:0100678)2.63661879
46Hypoplastic pelvis (HP:0008839)2.61620236
47Increased circulating renin level (HP:0000848)2.58593803
48Turricephaly (HP:0000262)2.53597576
49Thickened helices (HP:0000391)2.53405940
50Rapidly progressive (HP:0003678)2.53077061
51Distal lower limb amyotrophy (HP:0008944)2.48491707
52Ulnar bowing (HP:0003031)2.47664936
53* Leukodystrophy (HP:0002415)2.45851798
54Absent septum pellucidum (HP:0001331)2.45515446
55Morphological abnormality of the inner ear (HP:0011390)2.44976993
56Urinary urgency (HP:0000012)2.43292087
57Hand muscle atrophy (HP:0009130)2.42770035
58Segmental peripheral demyelination/remyelination (HP:0003481)2.42715585
59Autoamputation (HP:0001218)2.40519675
60* Intention tremor (HP:0002080)2.40144762
61Postural instability (HP:0002172)2.38620798
62Pheochromocytoma (HP:0002666)2.35719860
63Achilles tendon contracture (HP:0001771)2.35604016
64Febrile seizures (HP:0002373)2.34420130
65Cerebral aneurysm (HP:0004944)2.33365206
66Neuronal loss in central nervous system (HP:0002529)2.33331497
67Shallow orbits (HP:0000586)2.32941002
68* Cerebral hypomyelination (HP:0006808)2.32209353
69Protrusio acetabuli (HP:0003179)2.31854321
70Torticollis (HP:0000473)2.31692698
71Abnormality of the periventricular white matter (HP:0002518)2.31548844
72Coronal craniosynostosis (HP:0004440)2.28322066
73Methylmalonic acidemia (HP:0002912)2.27123954
74Split foot (HP:0001839)2.26970180
75Depression (HP:0000716)2.26540513
76Overriding aorta (HP:0002623)2.26225930
77Tetraplegia (HP:0002445)2.24914854
78Truncal ataxia (HP:0002078)2.24670306
79Infantile muscular hypotonia (HP:0008947)2.21591675
80Spastic tetraparesis (HP:0001285)2.19979683
81Hepatosplenomegaly (HP:0001433)2.19775101
82Hemorrhage of the eye (HP:0011885)2.19717990
83Broad face (HP:0000283)2.16785794
84Abnormal eating behavior (HP:0100738)2.15220085
85Hyperthyroidism (HP:0000836)2.15136349
86Esophageal atresia (HP:0002032)2.14513548
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14117818
88White forelock (HP:0002211)2.12777143
89Hypomagnesemia (HP:0002917)2.12425362
90Apathy (HP:0000741)2.11905023
91Abnormality of the Achilles tendon (HP:0005109)2.11333495
92Patchy hypopigmentation of hair (HP:0011365)2.11088277
93Lower limb muscle weakness (HP:0007340)2.10649023
94Cupped ear (HP:0000378)2.10192089
95Fragile skin (HP:0001030)2.09690630
96* Sensory axonal neuropathy (HP:0003390)2.08255513
97Erythroderma (HP:0001019)2.06962712
98Aplasia involving bones of the upper limbs (HP:0009823)2.06954863
99Aplasia of the phalanges of the hand (HP:0009802)2.06954863
100Aplasia involving bones of the extremities (HP:0009825)2.06954863
101Foot dorsiflexor weakness (HP:0009027)2.06396688
102Axonal loss (HP:0003447)2.05981632
103Metabolic alkalosis (HP:0200114)2.05714853
104Abnormality of the septum pellucidum (HP:0007375)2.04261843
105Anomalous pulmonary venous return (HP:0010772)2.03905666
106Hypoplasia of the iris (HP:0007676)2.03445577
107Neuroendocrine neoplasm (HP:0100634)2.02293187
108Megalencephaly (HP:0001355)2.02146205
109Clonus (HP:0002169)2.01551999
110Synostosis involving the elbow (HP:0003938)2.01138067
111Humeroradial synostosis (HP:0003041)2.01138067
112Renal Fanconi syndrome (HP:0001994)1.99261730
113Bowel incontinence (HP:0002607)1.98780920
114Generalized tonic-clonic seizures (HP:0002069)1.97444076
115Partial agenesis of the corpus callosum (HP:0001338)1.96769983
116Renovascular hypertension (HP:0100817)1.96473981
117Delusions (HP:0000746)1.95317340
118Diminished movement (HP:0002374)1.94293636
119Elfin facies (HP:0004428)1.93441987
120Truncus arteriosus (HP:0001660)1.93050435
121* Rigidity (HP:0002063)1.92449666
122Atonic seizures (HP:0010819)1.91471119
123Mildly elevated creatine phosphokinase (HP:0008180)1.90326196
124Generalized myoclonic seizures (HP:0002123)1.89944528
125Hypokalemic alkalosis (HP:0001949)1.89661766
126Diminished motivation (HP:0000745)1.88902436
127Partial duplication of thumb phalanx (HP:0009944)1.88445540
128Relative macrocephaly (HP:0004482)1.87582654
129Renal duplication (HP:0000075)1.87518101
130Abnormality of the foot musculature (HP:0001436)1.86535720
131Increased connective tissue (HP:0009025)1.85871921
132Abnormal large intestine physiology (HP:0012700)1.85395799
133Muscle fiber splitting (HP:0003555)1.85018735
134Action tremor (HP:0002345)1.83725658
135Urinary bladder sphincter dysfunction (HP:0002839)1.83465226
136Focal dystonia (HP:0004373)1.82336123
137Hammertoe (HP:0001765)1.81540909
138Morphological abnormality of the pyramidal tract (HP:0002062)1.80134082
139Pointed chin (HP:0000307)1.79443639
140Atrophic scars (HP:0001075)1.79370628
141Premature rupture of membranes (HP:0001788)1.78783642
142Adrenal hypoplasia (HP:0000835)1.77964038
143Polar cataract (HP:0010696)1.77401307
144Gowers sign (HP:0003391)1.77060593
145Steppage gait (HP:0003376)1.76143964
146Vaginal atresia (HP:0000148)1.75424141
147Bradykinesia (HP:0002067)1.75262907
148Hyperparathyroidism (HP:0000843)1.75078795
149Bladder diverticulum (HP:0000015)1.74585407
150Peripheral demyelination (HP:0011096)1.74505668
151Craniofacial dystonia (HP:0012179)1.73168371
152Abnormality of the pulmonary veins (HP:0011718)1.73124660
153* Distal sensory impairment (HP:0002936)1.72406360
154Chin dimple (HP:0010751)1.71511794
155Type II lissencephaly (HP:0007260)1.71452834
156Acanthosis nigricans (HP:0000956)1.70740365
157Loss of speech (HP:0002371)1.70299237
158Sleep apnea (HP:0010535)1.70081674
159Barrel-shaped chest (HP:0001552)1.69004126
160Abnormality of the salivary glands (HP:0010286)1.68805434
161Arnold-Chiari malformation (HP:0002308)1.68754011
162Abnormality of the lower motor neuron (HP:0002366)1.68737688
163Distal lower limb muscle weakness (HP:0009053)1.68167823
164Bowel diverticulosis (HP:0005222)1.67727019
165Cervical subluxation (HP:0003308)1.67481956
166Abnormality of the middle phalanges of the toes (HP:0010183)1.67432553
167* CNS hypomyelination (HP:0003429)1.66668296
168Myelomeningocele (HP:0002475)1.64302027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.60418253
2OXSR14.62131654
3SIK13.88786530
4EPHB13.54889759
5BCR2.88496094
6PKN12.74303134
7WNK42.72043533
8CDK192.71165021
9TNIK2.59691008
10EPHA22.50220037
11MET2.43815398
12TRIB32.43517735
13LMTK22.36652582
14PRKD32.32405634
15DAPK22.27131842
16PBK2.22762766
17NTRK32.17424172
18RIPK12.17078717
19IRAK32.14233351
20MAPKAPK52.12775884
21CAMKK12.08442740
22FGFR22.06003856
23WNK11.98625384
24UHMK11.96718327
25CSNK1G31.88946132
26LIMK11.82464979
27ICK1.77623584
28CSNK1A1L1.76757556
29NEK61.76447755
30PRPF4B1.73548035
31LATS21.73468881
32PNCK1.69232148
33MST1R1.67061422
34TESK11.64966023
35STK381.58681000
36ROCK21.57981749
37NTRK11.53534121
38CAMK2B1.50188895
39MST41.48842102
40CSNK1G11.46428515
41MAP3K111.46148319
42CLK11.45963788
43PAK61.43578779
44CSNK1G21.42844056
45FGR1.36085169
46DDR21.32831371
47EPHA41.28254277
48MINK11.27491532
49GRK51.26011771
50CAMK11.25653790
51CAMK2D1.23487306
52CAMKK21.21251338
53TESK21.18757632
54CASK1.17976309
55SGK2231.13522001
56SGK4941.13522001
57SIK21.09339611
58TYRO31.08652921
59DAPK11.04258840
60CAMK2G0.96813319
61MARK10.94647366
62PAK30.92338707
63MAP3K10.91359078
64PRKG20.90514670
65DYRK20.90403005
66MARK20.89808124
67CDK140.88273530
68ARAF0.88259295
69PDGFRA0.87799999
70MAPK150.83246411
71PRKCQ0.83192401
72CDK50.81169744
73IRAK20.77913066
74MUSK0.77785144
75CDK150.76035241
76TNK20.75357475
77CAMK2A0.74148880
78PRKD10.74102619
79PINK10.73490309
80MAP3K130.73142904
81PTK20.72556338
82PRKD20.70794832
83CDK180.70490710
84DYRK1B0.69403562
85TAOK20.68270577
86CDK11A0.67782306
87PDPK10.66069805
88PLK20.65310056
89CAMK1D0.65139479
90SGK30.64322096
91SMG10.62752136
92PRKCE0.62095776
93KSR20.61890024
94MAPK120.60869441
95FYN0.59900485
96IRAK10.57075255
97PHKG20.56973928
98PHKG10.56973928
99RIPK40.56783203
100ERN10.55512504
101MTOR0.53508407
102MAPK130.52330452
103ERBB40.52091821
104PRKCG0.51859142
105EEF2K0.50075833
106MAP3K60.49675642
107CSNK1D0.49666172
108RET0.48554756
109BRAF0.47660813
110MAP3K20.46656301
111ALK0.46074982
112NTRK20.45577607
113FGFR40.45087402
114RPS6KA50.44284429
115SGK20.43755127
116PRKG10.43457406
117CAMK40.43206074
118PRKCZ0.43015071
119STK110.42554335
120SGK10.42081735
121MAP2K20.40651589
122RPS6KA30.40651076
123RPS6KA20.40574110
124CSNK1A10.39903049
125PAK10.39215931
126PTK60.39148250
127FES0.38113110
128GSK3A0.35842889
129MAP3K90.35823033
130TRPM70.34639934
131BMX0.34201898
132BMPR1B0.32298834
133PDK10.32197852
134PRKACB0.31973640
135PRKCH0.31926113
136DAPK30.30522286
137PDGFRB0.28978102
138ROCK10.27862421
139PTK2B0.27457022
140MKNK10.26044938
141PRKACA0.25436808
142INSR0.25009287
143ADRBK20.24507216
144CSNK1E0.24397206
145MAPK100.23467057
146ITK0.22634492
147OBSCN0.21693247
148MAPK70.20743105
149DMPK0.20569253
150PIK3CA0.20283495
151DYRK1A0.20176737
152CAMK1G0.20161059
153GRK70.19934482

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.65661935
2Steroid biosynthesis_Homo sapiens_hsa001004.89154903
3Fatty acid elongation_Homo sapiens_hsa000624.55613581
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.58307583
5Ether lipid metabolism_Homo sapiens_hsa005653.01678710
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.75962522
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64770505
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.61245418
9Long-term potentiation_Homo sapiens_hsa047202.52614642
10Oxidative phosphorylation_Homo sapiens_hsa001902.04520735
11Axon guidance_Homo sapiens_hsa043601.97420700
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97299259
13Sulfur metabolism_Homo sapiens_hsa009201.94794185
14Protein export_Homo sapiens_hsa030601.90477141
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86333912
16Insulin secretion_Homo sapiens_hsa049111.84740588
17Vitamin B6 metabolism_Homo sapiens_hsa007501.73325705
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71940405
19Sphingolipid metabolism_Homo sapiens_hsa006001.71629067
20Butanoate metabolism_Homo sapiens_hsa006501.59853200
21Linoleic acid metabolism_Homo sapiens_hsa005911.59727350
22Histidine metabolism_Homo sapiens_hsa003401.51387357
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47744905
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44563018
25Parkinsons disease_Homo sapiens_hsa050121.42965247
26Alzheimers disease_Homo sapiens_hsa050101.38425279
27Estrogen signaling pathway_Homo sapiens_hsa049151.36462122
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35832068
29Nitrogen metabolism_Homo sapiens_hsa009101.35817510
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35540788
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33380689
32GnRH signaling pathway_Homo sapiens_hsa049121.32908091
33Oxytocin signaling pathway_Homo sapiens_hsa049211.31838428
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29310031
35GABAergic synapse_Homo sapiens_hsa047271.28638398
36Glutamatergic synapse_Homo sapiens_hsa047241.27628343
37Serotonergic synapse_Homo sapiens_hsa047261.26996413
38Glioma_Homo sapiens_hsa052141.26848624
39Renal cell carcinoma_Homo sapiens_hsa052111.17546037
40Calcium signaling pathway_Homo sapiens_hsa040201.16334143
41Arginine and proline metabolism_Homo sapiens_hsa003301.15499709
42Bile secretion_Homo sapiens_hsa049761.15042040
43Inositol phosphate metabolism_Homo sapiens_hsa005621.14063611
44VEGF signaling pathway_Homo sapiens_hsa043701.10274556
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04679388
46Long-term depression_Homo sapiens_hsa047301.04563848
47Vibrio cholerae infection_Homo sapiens_hsa051101.01498937
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.01272535
49Collecting duct acid secretion_Homo sapiens_hsa049661.00749683
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99925745
51Melanogenesis_Homo sapiens_hsa049160.96805417
52Morphine addiction_Homo sapiens_hsa050320.95706416
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94399050
54Tight junction_Homo sapiens_hsa045300.90758579
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90532234
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90203416
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89109135
58Rap1 signaling pathway_Homo sapiens_hsa040150.88254860
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.85457506
60Thyroid hormone synthesis_Homo sapiens_hsa049180.84384340
61Fatty acid metabolism_Homo sapiens_hsa012120.83605718
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83365487
63Cardiac muscle contraction_Homo sapiens_hsa042600.83130236
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82483127
65AMPK signaling pathway_Homo sapiens_hsa041520.80135442
66Endocytosis_Homo sapiens_hsa041440.80119130
67Taste transduction_Homo sapiens_hsa047420.80100878
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78868236
69Insulin signaling pathway_Homo sapiens_hsa049100.77506259
70Rheumatoid arthritis_Homo sapiens_hsa053230.77138435
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76672749
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76290157
73Cocaine addiction_Homo sapiens_hsa050300.75757797
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74160812
75Glutathione metabolism_Homo sapiens_hsa004800.72876969
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71704858
77Ovarian steroidogenesis_Homo sapiens_hsa049130.70996846
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70972407
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.70840410
80Ras signaling pathway_Homo sapiens_hsa040140.70604250
81Notch signaling pathway_Homo sapiens_hsa043300.70561507
82Circadian entrainment_Homo sapiens_hsa047130.70029074
83Dilated cardiomyopathy_Homo sapiens_hsa054140.69416906
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69175282
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.67859604
86Arachidonic acid metabolism_Homo sapiens_hsa005900.67788350
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.67046540
88Arginine biosynthesis_Homo sapiens_hsa002200.66781593
89Focal adhesion_Homo sapiens_hsa045100.66112159
90Glucagon signaling pathway_Homo sapiens_hsa049220.65856563
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65057472
92Huntingtons disease_Homo sapiens_hsa050160.65044377
93Lysosome_Homo sapiens_hsa041420.64968956
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64628515
95mTOR signaling pathway_Homo sapiens_hsa041500.64553030
96Synaptic vesicle cycle_Homo sapiens_hsa047210.64381347
97Non-small cell lung cancer_Homo sapiens_hsa052230.64277016
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.62890130
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.62677640
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60439934
101Salivary secretion_Homo sapiens_hsa049700.59807936
102Chronic myeloid leukemia_Homo sapiens_hsa052200.59399107
103Propanoate metabolism_Homo sapiens_hsa006400.59060246
104ErbB signaling pathway_Homo sapiens_hsa040120.59058303
105Dopaminergic synapse_Homo sapiens_hsa047280.58725805
106Type II diabetes mellitus_Homo sapiens_hsa049300.58633083
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57794737
108Olfactory transduction_Homo sapiens_hsa047400.57581588
109Cholinergic synapse_Homo sapiens_hsa047250.57275738
110Autoimmune thyroid disease_Homo sapiens_hsa053200.57208758
111Phototransduction_Homo sapiens_hsa047440.56753222
112beta-Alanine metabolism_Homo sapiens_hsa004100.55575406
113Peroxisome_Homo sapiens_hsa041460.53599850
114Gastric acid secretion_Homo sapiens_hsa049710.53144238
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52169630
116Nicotine addiction_Homo sapiens_hsa050330.51780230
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.51207154
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50740401
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49516889
120Dorso-ventral axis formation_Homo sapiens_hsa043200.49316854
121Endometrial cancer_Homo sapiens_hsa052130.49282730
122Pancreatic secretion_Homo sapiens_hsa049720.49056885
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48800997
124Mineral absorption_Homo sapiens_hsa049780.48195286
125Phagosome_Homo sapiens_hsa041450.46161948
126Circadian rhythm_Homo sapiens_hsa047100.45221632
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43616495
128Fatty acid biosynthesis_Homo sapiens_hsa000610.42619363
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41879861
130Gap junction_Homo sapiens_hsa045400.41006825
131Metabolic pathways_Homo sapiens_hsa011000.40125650
132Folate biosynthesis_Homo sapiens_hsa007900.40066484
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37582042
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36648919
135Malaria_Homo sapiens_hsa051440.36633285
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34537784
137Choline metabolism in cancer_Homo sapiens_hsa052310.34368349
138ECM-receptor interaction_Homo sapiens_hsa045120.33954579
139Renin secretion_Homo sapiens_hsa049240.33211760
140Hedgehog signaling pathway_Homo sapiens_hsa043400.33022655
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31169501
142cAMP signaling pathway_Homo sapiens_hsa040240.28917822
143Alcoholism_Homo sapiens_hsa050340.26813542
144Prion diseases_Homo sapiens_hsa050200.26544133
145Chemical carcinogenesis_Homo sapiens_hsa052040.25956703
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25790156
147Vitamin digestion and absorption_Homo sapiens_hsa049770.25448675
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25238677
149Amphetamine addiction_Homo sapiens_hsa050310.25169261
150MAPK signaling pathway_Homo sapiens_hsa040100.24473406
151Regulation of autophagy_Homo sapiens_hsa041400.23071278
152ABC transporters_Homo sapiens_hsa020100.22260224

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