GJD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1barbed-end actin filament capping (GO:0051016)9.88650312
2sequestering of actin monomers (GO:0042989)8.51555250
3homeostasis of number of cells within a tissue (GO:0048873)8.25088266
4mast cell activation involved in immune response (GO:0002279)6.39134456
5mast cell degranulation (GO:0043303)6.39134456
6erythrocyte maturation (GO:0043249)5.80940783
7DNA deamination (GO:0045006)5.29079623
8T cell migration (GO:0072678)5.24346605
9mast cell activation (GO:0045576)5.21378423
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.01787480
11Golgi transport vesicle coating (GO:0048200)4.91955332
12COPI coating of Golgi vesicle (GO:0048205)4.91955332
13dorsal/ventral axis specification (GO:0009950)4.86453083
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.82657856
15proline biosynthetic process (GO:0006561)4.79934162
16synaptic vesicle maturation (GO:0016188)4.77902664
17regulation of gamma-delta T cell differentiation (GO:0045586)4.72006618
18negative regulation of actin filament polymerization (GO:0030837)4.40441867
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.22619229
20T cell receptor signaling pathway (GO:0050852)4.19327524
21dermatan sulfate biosynthetic process (GO:0030208)4.12039957
22regulation of gamma-delta T cell activation (GO:0046643)4.07739058
23actin filament capping (GO:0051693)4.04787385
24synaptic vesicle exocytosis (GO:0016079)3.98731949
25response to pheromone (GO:0019236)3.98615151
26cerebellar Purkinje cell layer development (GO:0021680)3.97938443
27negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.94078941
28leukocyte tethering or rolling (GO:0050901)3.93873931
29negative regulation of protein polymerization (GO:0032272)3.90754000
30dermatan sulfate metabolic process (GO:0030205)3.90616867
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88183407
32regulation of apoptotic process involved in morphogenesis (GO:1902337)3.87392848
33positive regulation of gamma-delta T cell activation (GO:0046645)3.85875457
34regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.84710652
35pentose-phosphate shunt (GO:0006098)3.84649473
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.83003934
37desmosome organization (GO:0002934)3.78786502
38dendritic spine morphogenesis (GO:0060997)3.76793935
39negative regulation of cell killing (GO:0031342)3.76385603
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76385603
41interferon-gamma production (GO:0032609)3.74965640
42protein retention in ER lumen (GO:0006621)3.72521479
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70371457
44anterograde synaptic vesicle transport (GO:0048490)3.67974715
45regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.65089515
46negative regulation of phagocytosis (GO:0050765)3.64269060
47adherens junction assembly (GO:0034333)3.64042262
48regulation of B cell receptor signaling pathway (GO:0050855)3.63681619
49regulation of synaptic vesicle exocytosis (GO:2000300)3.61170215
50cell-substrate adherens junction assembly (GO:0007045)3.61078517
51focal adhesion assembly (GO:0048041)3.61078517
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60212991
53glucose catabolic process (GO:0006007)3.57137064
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.56569995
55pinocytosis (GO:0006907)3.52780742
56protein localization to endosome (GO:0036010)3.49206998
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44497405
58maternal placenta development (GO:0001893)3.43769968
59regulation of early endosome to late endosome transport (GO:2000641)3.43744396
60pyrimidine nucleobase catabolic process (GO:0006208)3.43465389
61lysosome localization (GO:0032418)3.43330100
62negative regulation of cell size (GO:0045792)3.41614923
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40640614
64glutamate secretion (GO:0014047)3.38997466
65apoptotic process involved in morphogenesis (GO:0060561)3.38961160
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38160005
67regulation of defense response to virus by virus (GO:0050690)3.36933929
68negative thymic T cell selection (GO:0045060)3.36561890
69epithelial cell-cell adhesion (GO:0090136)3.36473370
70proline metabolic process (GO:0006560)3.36366091
71vocalization behavior (GO:0071625)3.36110508
72regulation of short-term neuronal synaptic plasticity (GO:0048172)3.34225432
73lymph vessel development (GO:0001945)3.31915941
74NADPH regeneration (GO:0006740)3.31660610
75dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31377515
76negative regulation of fatty acid transport (GO:2000192)3.30581145
77antigen receptor-mediated signaling pathway (GO:0050851)3.28888563
78protein localization to synapse (GO:0035418)3.28039215
79regulation of T cell receptor signaling pathway (GO:0050856)3.27093104
80locomotory exploration behavior (GO:0035641)3.24922988
81negative T cell selection (GO:0043383)3.24461230
82branching involved in mammary gland duct morphogenesis (GO:0060444)3.22760249
83ectoderm development (GO:0007398)3.17811161
84response to xenobiotic stimulus (GO:0009410)3.16893585
85pyrimidine nucleotide catabolic process (GO:0006244)3.16323698
86cellular zinc ion homeostasis (GO:0006882)3.16060663
87vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.15643919
88protein maturation by protein folding (GO:0022417)3.15109093
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14838733
90peptidyl-arginine omega-N-methylation (GO:0035247)3.13327019
91layer formation in cerebral cortex (GO:0021819)3.11864574
92viral genome replication (GO:0019079)3.10457628
93cell-substrate junction assembly (GO:0007044)3.07573869
94negative regulation of actin filament depolymerization (GO:0030835)3.07244523
95positive regulation of keratinocyte differentiation (GO:0045618)3.05143992
96endothelial cell chemotaxis (GO:0035767)3.04669004
97positive regulation of Cdc42 GTPase activity (GO:0043089)3.04339211
98regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02706961
99cullin deneddylation (GO:0010388)3.02674350
100regulation of glucocorticoid metabolic process (GO:0031943)3.01896633
101skin morphogenesis (GO:0043589)3.01304661
102regulation of fatty acid beta-oxidation (GO:0031998)3.01297096
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99677891
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99369387
105positive regulation of uterine smooth muscle contraction (GO:0070474)2.99230340
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.96197037
107thymic T cell selection (GO:0045061)2.95473065
108activation of Rac GTPase activity (GO:0032863)2.95184777
109mammary gland epithelial cell differentiation (GO:0060644)2.94706564
110protein deneddylation (GO:0000338)2.93932647
111leukocyte degranulation (GO:0043299)2.93869879
112basement membrane organization (GO:0071711)2.91440360
113sodium ion export (GO:0071436)2.91117249
114glucose 6-phosphate metabolic process (GO:0051156)2.89599163
115amyloid precursor protein catabolic process (GO:0042987)2.89540358
116regulation of synaptic vesicle transport (GO:1902803)2.89207964
117regulation of isotype switching to IgG isotypes (GO:0048302)2.89047225
118nucleobase catabolic process (GO:0046113)2.88551004
119embryonic eye morphogenesis (GO:0048048)2.87297653
120negative regulation of viral release from host cell (GO:1902187)2.86409947
121clathrin coat assembly (GO:0048268)2.85622661
122regulation of response to osmotic stress (GO:0047484)2.85322657
123receptor clustering (GO:0043113)2.85034082
124negative regulation of erythrocyte differentiation (GO:0045647)2.82113807
125regulation of translational fidelity (GO:0006450)2.81389765
126very long-chain fatty acid metabolic process (GO:0000038)2.79882502
127regulation of glutamate receptor signaling pathway (GO:1900449)2.79774576
128regulation of translational termination (GO:0006449)2.79340030
129endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.78502732
130regulation of uterine smooth muscle contraction (GO:0070472)2.77712334
131atrioventricular valve morphogenesis (GO:0003181)2.76934848
132lymphocyte migration (GO:0072676)2.76854043
133vascular endothelial growth factor signaling pathway (GO:0038084)2.75540638
134regulation of neuronal synaptic plasticity (GO:0048168)2.74277728
135Peyers patch development (GO:0048541)2.73660269
136mucosal-associated lymphoid tissue development (GO:0048537)2.73660269
137membrane assembly (GO:0071709)2.72838266
138oxidative demethylation (GO:0070989)2.72083034
139regulation of actin filament depolymerization (GO:0030834)2.71723371
140negative regulation of JAK-STAT cascade (GO:0046426)2.70433409
141anterograde axon cargo transport (GO:0008089)2.70303341
142cellular response to zinc ion (GO:0071294)2.70276642
143embryonic skeletal joint morphogenesis (GO:0060272)2.70122006
144protein localization to microtubule (GO:0035372)2.68334052
145hyaluronan catabolic process (GO:0030214)2.67993891
146establishment of nucleus localization (GO:0040023)2.66168481
147diaphragm development (GO:0060539)2.64852208
148embryo implantation (GO:0007566)2.63888224
149B cell receptor signaling pathway (GO:0050853)2.63797519
150adaptation of signaling pathway (GO:0023058)2.63061771
151negative regulation of leukocyte chemotaxis (GO:0002689)2.62568503
152ether lipid metabolic process (GO:0046485)2.62170748
153heterotypic cell-cell adhesion (GO:0034113)2.60246291
154regulation of integrin activation (GO:0033623)2.59389070
155negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.58681580
156UV protection (GO:0009650)2.57347652
157activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.57214463
158modulation by virus of host morphology or physiology (GO:0019048)2.56895726
159negative regulation of type 2 immune response (GO:0002829)2.56514542
160semaphorin-plexin signaling pathway (GO:0071526)2.55537009
161neuron cell-cell adhesion (GO:0007158)2.54834841
162positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.53895564
163folic acid transport (GO:0015884)2.53575363
164regulation of histone H3-K27 methylation (GO:0061085)2.53042587
165regulation of synapse structural plasticity (GO:0051823)2.52657750
166homeostasis of number of cells (GO:0048872)2.52580361
167zinc ion homeostasis (GO:0055069)2.51598148
168dendritic spine organization (GO:0097061)2.51334879
169regulation of water loss via skin (GO:0033561)2.50704058
170modulation by symbiont of host cellular process (GO:0044068)2.49211352
171adenine nucleotide transport (GO:0051503)2.49010928
172vagina development (GO:0060068)2.48142202
173positive regulation of nuclease activity (GO:0032075)2.48070814
174regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46336641
175spliceosomal tri-snRNP complex assembly (GO:0000244)2.46286834
176establishment of apical/basal cell polarity (GO:0035089)2.44758101
177positive regulation of epidermis development (GO:0045684)2.43860347
178epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43469559
179pentose metabolic process (GO:0019321)2.41486578
180modulation by virus of host process (GO:0019054)2.41331563
181outflow tract septum morphogenesis (GO:0003148)2.41241544
182mannose metabolic process (GO:0006013)2.40346219
183regulation of extracellular matrix disassembly (GO:0010715)2.39950093
184peptidyl-arginine N-methylation (GO:0035246)2.39327259
185peptidyl-arginine methylation (GO:0018216)2.39327259
186cochlea morphogenesis (GO:0090103)2.38726794
187nuclear envelope reassembly (GO:0031468)2.37096103
188mitotic nuclear envelope reassembly (GO:0007084)2.37096103
189Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.37063769
190glutamine family amino acid biosynthetic process (GO:0009084)2.36192307
191purine nucleotide transport (GO:0015865)2.36057465
192positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.35675903
193endoplasmic reticulum unfolded protein response (GO:0030968)2.35323158
194stress fiber assembly (GO:0043149)2.35230408
195GDP-mannose metabolic process (GO:0019673)2.34071234
196nucleobase-containing small molecule interconversion (GO:0015949)2.33696615
197negative regulation of adherens junction organization (GO:1903392)2.32897728
198negative regulation of cell junction assembly (GO:1901889)2.32897728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81370396
2SRY_22984422_ChIP-ChIP_TESTIS_Rat4.65912674
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.08290184
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37047457
5ZNF263_19887448_ChIP-Seq_K562_Human2.69366290
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66933916
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64851020
8MYC_22102868_ChIP-Seq_BL_Human2.64435760
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.54163773
10LXR_22292898_ChIP-Seq_THP-1_Human2.52411628
11SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.40587641
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37449656
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35533467
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32504609
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31594417
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.28031967
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21393083
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20632465
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.19531425
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15443241
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13334672
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08135618
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06729019
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00657671
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98685801
26KDM2B_26808549_Chip-Seq_DND41_Human1.92255862
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.90838186
28UTX_26944678_Chip-Seq_JUKART_Human1.89886335
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88132369
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88015081
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.86907857
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81994521
33MAF_26560356_Chip-Seq_TH2_Human1.81882605
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79260457
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75735785
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70725880
37E2F7_22180533_ChIP-Seq_HELA_Human1.70679216
38MAF_26560356_Chip-Seq_TH1_Human1.70326290
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.69665978
40RUNX_20019798_ChIP-Seq_JUKART_Human1.67364102
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65256885
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64440207
43CTCF_18555785_ChIP-Seq_MESCs_Mouse1.64000566
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.62698301
45MYB_26560356_Chip-Seq_TH2_Human1.62310237
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60734760
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.59362707
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59155662
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58845886
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58135505
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57896342
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55811798
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.55392746
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54084229
55EGR1_19032775_ChIP-ChIP_M12_Human1.52063076
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51764735
57* KDM2B_26808549_Chip-Seq_K562_Human1.48899671
58* PHF8_20622854_ChIP-Seq_HELA_Human1.48503703
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48365628
60TCF7_22412390_ChIP-Seq_EML_Mouse1.47942401
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46827829
62ATF3_27146783_Chip-Seq_COLON_Human1.45619949
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45044181
64CTCF_27219007_Chip-Seq_Bcells_Human1.45018676
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.44783695
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44441564
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.44265336
68MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41864509
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.40900750
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40705509
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39955738
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39181205
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.38515323
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36832147
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35520141
76TP53_22127205_ChIP-Seq_IMR90_Human1.35427002
77P68_20966046_ChIP-Seq_HELA_Human1.35242848
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.35135797
79FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34952522
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34548823
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.34443011
82SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.33625930
83CLOCK_20551151_ChIP-Seq_293T_Human1.33622429
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33573203
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32400597
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32368393
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32248205
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31678177
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.31354379
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31327287
91FLI1_21867929_ChIP-Seq_CD8_Mouse1.31308343
92MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31237243
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30989915
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.30165289
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27471737
96SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27226955
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26897478
98ZNF274_21170338_ChIP-Seq_K562_Hela1.26567733
99CREB1_26743006_Chip-Seq_LNCaP_Human1.25645288
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25095450
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24520247
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24196884
103VDR_21846776_ChIP-Seq_THP-1_Human1.24035477
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23856646
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23578330
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23296136
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22777776
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22692837
109TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22350107
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21173309
111MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.21110634
112* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21004785
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20685559
114IRF8_22096565_ChIP-ChIP_GC-B_Human1.19319805
115KDM2B_26808549_Chip-Seq_JURKAT_Human1.19279646
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19071687
117NCOR1_26117541_ChIP-Seq_K562_Human1.18971714
118REST_21632747_ChIP-Seq_MESCs_Mouse1.18576172
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18572531
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.17592448
121* SA1_27219007_Chip-Seq_Bcells_Human1.17560777
122MYC_18940864_ChIP-ChIP_HL60_Human1.17111047
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16882859
124* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16325466
125* SMC4_20622854_ChIP-Seq_HELA_Human1.16272705
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16261773
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16182420
128SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15962827
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15828848
130STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14356023
131* VDR_24763502_ChIP-Seq_THP-1_Human1.13119784
132* CTCF_21964334_Chip-Seq_Bcells_Human1.12176788
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11840471
134* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11771578
135FOXM1_23109430_ChIP-Seq_U2OS_Human1.11090811
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10546414
137CTCF_26484167_Chip-Seq_Bcells_Mouse1.10514466
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09693996
139PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09420494
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09329645
141BCL6_27268052_Chip-Seq_Bcells_Human1.09089370
142MYB_26560356_Chip-Seq_TH1_Human1.08818060
143TRIM28_21343339_ChIP-Seq_HEK293_Human1.08410930
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08196615
145DROSHA_22980978_ChIP-Seq_HELA_Human1.07391655
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06475644
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06075762
148MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05894339
149GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05011332
150TET1_21490601_ChIP-Seq_MESCs_Mouse1.04599554
151* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04198377
152UBF1/2_26484160_Chip-Seq_HMECs_Human1.03927024
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03496968
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02832413
155XRN2_22483619_ChIP-Seq_HELA_Human1.02607332
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02543253
157UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02459832
158CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01372878
159DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00123155
160RXR_22158963_ChIP-Seq_LIVER_Mouse1.00061636
161GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99980402
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.99749472
163STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99689801
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99232521
165MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99081573
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.96976264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.51589610
2MP0004859_abnormal_synaptic_plasticity4.97996143
3MP0003172_abnormal_lysosome_physiology3.34692925
4MP0003880_abnormal_central_pattern3.34032835
5MP0003763_abnormal_thymus_physiology3.26844555
6MP0000685_abnormal_immune_system3.23619879
7MP0002877_abnormal_melanocyte_morpholog3.19969553
8MP0008438_abnormal_cutaneous_collagen3.19110860
9MP0003123_paternal_imprinting3.18823411
10MP0002909_abnormal_adrenal_gland2.99615176
11MP0003879_abnormal_hair_cell2.89091895
12MP0003635_abnormal_synaptic_transmissio2.86100714
13MP0005423_abnormal_somatic_nervous2.84208711
14MP0005451_abnormal_body_composition2.81593024
15MP0005076_abnormal_cell_differentiation2.77464994
16MP0004270_analgesia2.69999161
17MP0005623_abnormal_meninges_morphology2.65049115
18MP0003329_amyloid_beta_deposits2.59649617
19MP0005058_abnormal_lysosome_morphology2.43987111
20MP0002933_joint_inflammation2.40585841
21MP0003566_abnormal_cell_adhesion2.39508828
22MP0002796_impaired_skin_barrier2.39434132
23MP0009745_abnormal_behavioral_response2.39194373
24MP0005174_abnormal_tail_pigmentation2.39103079
25MP0004858_abnormal_nervous_system2.38177869
26MP0005075_abnormal_melanosome_morpholog2.37972207
27MP0005671_abnormal_response_to2.30687381
28MP0002249_abnormal_larynx_morphology2.08730947
29MP0005501_abnormal_skin_physiology2.08645279
30MP0004185_abnormal_adipocyte_glucose2.08465167
31MP0002064_seizures2.07463083
32MP0004510_myositis2.04675702
33MP0000678_abnormal_parathyroid_gland2.01200343
34MP0004272_abnormal_basement_membrane1.97601830
35MP0003191_abnormal_cellular_cholesterol1.92231150
36MP0009840_abnormal_foam_cell1.91609248
37MP0000703_abnormal_thymus_morphology1.86540213
38MP0002063_abnormal_learning/memory/cond1.86406851
39MP0001849_ear_inflammation1.85955412
40MP0001529_abnormal_vocalization1.80165704
41MP0003633_abnormal_nervous_system1.80072385
42MP0005257_abnormal_intraocular_pressure1.79210103
43MP0004233_abnormal_muscle_weight1.75268464
44MP0003453_abnormal_keratinocyte_physiol1.73183961
45MP0002723_abnormal_immune_serum1.72499264
46MP0002420_abnormal_adaptive_immunity1.68817261
47MP0005410_abnormal_fertilization1.68681522
48MP0001819_abnormal_immune_cell1.67117127
49MP0002398_abnormal_bone_marrow1.64758296
50MP0001800_abnormal_humoral_immune1.62356438
51MP0005464_abnormal_platelet_physiology1.59586755
52MP0002272_abnormal_nervous_system1.57865462
53MP0002060_abnormal_skin_morphology1.54796378
54MP0005409_darkened_coat_color1.53970373
55MP0005000_abnormal_immune_tolerance1.52382465
56MP0005645_abnormal_hypothalamus_physiol1.51199752
57MP0000858_altered_metastatic_potential1.45855750
58MP0002837_dystrophic_cardiac_calcinosis1.45763081
59MP0009053_abnormal_anal_canal1.45256232
60MP0005310_abnormal_salivary_gland1.45065634
61MP0002098_abnormal_vibrissa_morphology1.44922976
62MP0009384_cardiac_valve_regurgitation1.44277843
63MP0001958_emphysema1.43900806
64MP0004782_abnormal_surfactant_physiolog1.43635777
65MP0002452_abnormal_antigen_presenting1.43297848
66MP0001790_abnormal_immune_system1.42966472
67MP0005387_immune_system_phenotype1.42966472
68MP0009278_abnormal_bone_marrow1.41839293
69MP0002572_abnormal_emotion/affect_behav1.40642117
70MP0003091_abnormal_cell_migration1.38882664
71MP0000733_abnormal_muscle_development1.36040371
72MP0003942_abnormal_urinary_system1.35754020
73MP0003890_abnormal_embryonic-extraembry1.35471489
74MP0000604_amyloidosis1.33898789
75MP0001873_stomach_inflammation1.32774931
76MP0000003_abnormal_adipose_tissue1.32661151
77MP0002405_respiratory_system_inflammati1.30279580
78MP0000716_abnormal_immune_system1.29731581
79MP0000681_abnormal_thyroid_gland1.29356346
80MP0004811_abnormal_neuron_physiology1.28636580
81MP0010234_abnormal_vibrissa_follicle1.27758512
82MP0000534_abnormal_ureter_morphology1.26910414
83MP0005025_abnormal_response_to1.26564305
84* MP0003137_abnormal_impulse_conducting1.26223064
85MP0002722_abnormal_immune_system1.26222534
86MP0005275_abnormal_skin_tensile1.26163454
87MP0010030_abnormal_orbit_morphology1.26056050
88MP0002006_tumorigenesis1.24255618
89MP0008260_abnormal_autophagy1.21208606
90MP0000371_diluted_coat_color1.19818392
91MP0001440_abnormal_grooming_behavior1.19287558
92MP0005167_abnormal_blood-brain_barrier1.18309172
93MP0000462_abnormal_digestive_system1.18129676
94MP0001346_abnormal_lacrimal_gland1.17344269
95MP0004264_abnormal_extraembryonic_tissu1.15373806
96MP0000689_abnormal_spleen_morphology1.13916445
97MP0000467_abnormal_esophagus_morphology1.13846979
98MP0001486_abnormal_startle_reflex1.13748744
99MP0003866_abnormal_defecation1.13510559
100MP0001216_abnormal_epidermal_layer1.13431590
101MP0001881_abnormal_mammary_gland1.12295941
102MP0009046_muscle_twitch1.12194848
103MP0008569_lethality_at_weaning1.11962407
104MP0000920_abnormal_myelination1.11152356
105MP0002429_abnormal_blood_cell1.09854042
106MP0004133_heterotaxia1.07411810
107MP0005023_abnormal_wound_healing1.06947698
108MP0005375_adipose_tissue_phenotype1.06910172
109MP0005666_abnormal_adipose_tissue1.05392553
110MP0000767_abnormal_smooth_muscle1.04147560
111MP0000627_abnormal_mammary_gland1.03103247
112MP0010352_gastrointestinal_tract_polyps1.00137524
113MP0005508_abnormal_skeleton_morphology0.99959908
114MP0000015_abnormal_ear_pigmentation0.99156934
115MP0001968_abnormal_touch/_nociception0.99104296
116MP0009931_abnormal_skin_appearance0.96746566
117MP0005503_abnormal_tendon_morphology0.95973570
118MP0003631_nervous_system_phenotype0.95107388
119MP0002089_abnormal_postnatal_growth/wei0.94210623
120MP0001243_abnormal_dermal_layer0.93881597
121MP0004947_skin_inflammation0.92420201
122MP0002166_altered_tumor_susceptibility0.91727483
123MP0010771_integument_phenotype0.90241862
124MP0003121_genomic_imprinting0.89932355
125MP0005083_abnormal_biliary_tract0.88294029
126MP0005360_urolithiasis0.88033983
127MP0004808_abnormal_hematopoietic_stem0.86124555
128MP0001188_hyperpigmentation0.84565343
129MP0009250_abnormal_appendicular_skeleto0.84509800
130MP0008770_decreased_survivor_rate0.84327987
131MP0002066_abnormal_motor_capabilities/c0.84261092
132MP0000538_abnormal_urinary_bladder0.84196610
133MP0001835_abnormal_antigen_presentation0.83967446
134MP0005621_abnormal_cell_physiology0.83937794
135MP0002419_abnormal_innate_immunity0.83831783
136MP0005330_cardiomyopathy0.83805680
137MP0000377_abnormal_hair_follicle0.83208621
138MP0008877_abnormal_DNA_methylation0.82775160
139MP0009780_abnormal_chondrocyte_physiolo0.82145770
140MP0000762_abnormal_tongue_morphology0.81573156
141MP0000537_abnormal_urethra_morphology0.80934257
142MP0003941_abnormal_skin_development0.80864759
143MP0000759_abnormal_skeletal_muscle0.80586891
144MP0010155_abnormal_intestine_physiology0.80314539
145MP0000350_abnormal_cell_proliferation0.80043287
146MP0009672_abnormal_birth_weight0.79323403
147MP0002896_abnormal_bone_mineralization0.78993906
148MP0003115_abnormal_respiratory_system0.78195218
149MP0002184_abnormal_innervation0.77979761
150MP0001485_abnormal_pinna_reflex0.77277678
151MP0002080_prenatal_lethality0.77147235
152MP0000490_abnormal_crypts_of0.76987155
153MP0001661_extended_life_span0.76713355
154MP0000013_abnormal_adipose_tissue0.74988792
155MP0004085_abnormal_heartbeat0.73218724
156MP0002882_abnormal_neuron_morphology0.72931924
157MP0000579_abnormal_nail_morphology0.71936720
158MP0003111_abnormal_nucleus_morphology0.71350059
159MP0000751_myopathy0.71036900
160MP0001727_abnormal_embryo_implantation0.70087927
161MP0002086_abnormal_extraembryonic_tissu0.70020198
162MP0009785_altered_susceptibility_to0.69993568
163MP0002396_abnormal_hematopoietic_system0.69606725
164MP0002653_abnormal_ependyma_morphology0.68789414
165MP0001970_abnormal_pain_threshold0.68251987
166MP0010630_abnormal_cardiac_muscle0.68149127
167MP0001501_abnormal_sleep_pattern0.67410111
168MP0000477_abnormal_intestine_morphology0.67283433
169MP0009333_abnormal_splenocyte_physiolog0.66795536
170MP0002970_abnormal_white_adipose0.66653377
171MP0010307_abnormal_tumor_latency0.66086489
172MP0002234_abnormal_pharynx_morphology0.65622003
173MP0002733_abnormal_thermal_nociception0.65438744
174MP0000747_muscle_weakness0.64776105
175MP0001348_abnormal_lacrimal_gland0.64485090
176MP0002697_abnormal_eye_size0.64450871
177MP0001915_intracranial_hemorrhage0.64236481
178MP0000613_abnormal_salivary_gland0.64228560
179MP0000566_synostosis0.63713286
180MP0003656_abnormal_erythrocyte_physiolo0.63395678
181MP0001845_abnormal_inflammatory_respons0.62434152
182MP0001545_abnormal_hematopoietic_system0.62420835
183MP0005397_hematopoietic_system_phenotyp0.62420835
184MP0001542_abnormal_bone_strength0.61651976
185MP0010368_abnormal_lymphatic_system0.61298733
186MP0001730_embryonic_growth_arrest0.61229660
187MP0002557_abnormal_social/conspecific_i0.57359711
188MP0000343_altered_response_to0.57225244
189MP0003279_aneurysm0.57147741
190MP0000955_abnormal_spinal_cord0.57090732

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)7.32878047
2Focal motor seizures (HP:0011153)6.52739010
3Amyotrophic lateral sclerosis (HP:0007354)5.13803992
4Absence seizures (HP:0002121)5.05103321
5Diastasis recti (HP:0001540)4.74464742
6Ragged-red muscle fibers (HP:0003200)4.71825346
7Distal arthrogryposis (HP:0005684)4.65500583
8Stomatitis (HP:0010280)4.64378953
9Focal seizures (HP:0007359)4.36209974
10Atrophy/Degeneration involving motor neurons (HP:0007373)4.33328431
11Protrusio acetabuli (HP:0003179)4.31949375
12Dialeptic seizures (HP:0011146)4.31584554
13Microretrognathia (HP:0000308)4.09957736
14Severe visual impairment (HP:0001141)4.09597551
15Degeneration of anterior horn cells (HP:0002398)4.08736611
16Abnormality of the anterior horn cell (HP:0006802)4.08736611
17IgM deficiency (HP:0002850)4.05350627
18Premature rupture of membranes (HP:0001788)3.98828392
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.96829015
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.96829015
21Hyperacusis (HP:0010780)3.88497832
22Spastic tetraparesis (HP:0001285)3.78220008
23Microvesicular hepatic steatosis (HP:0001414)3.54525479
24Increased IgM level (HP:0003496)3.50280249
25Vertebral compression fractures (HP:0002953)3.47094965
26Fragile skin (HP:0001030)3.33729112
27Ulnar bowing (HP:0003031)3.22485912
28Abnormality of glycolysis (HP:0004366)3.09130441
29Increased serum pyruvate (HP:0003542)3.09130441
30Achilles tendon contracture (HP:0001771)3.01422514
31Hematochezia (HP:0002573)2.99749554
32Septate vagina (HP:0001153)2.96108923
33Recurrent bronchitis (HP:0002837)2.91331344
34IgG deficiency (HP:0004315)2.83320852
35Distal lower limb muscle weakness (HP:0009053)2.82534080
36Mutism (HP:0002300)2.81992979
37Abnormality of the distal phalanges of the toes (HP:0010182)2.79243613
38Pustule (HP:0200039)2.77922169
39Abnormality of the fetal cardiovascular system (HP:0010948)2.75368731
40Abnormal umbilical cord blood vessels (HP:0011403)2.75368731
41Single umbilical artery (HP:0001195)2.75368731
42Asymmetry of the thorax (HP:0001555)2.74828182
43Abnormality of the umbilical cord (HP:0010881)2.73763156
44Thin bony cortex (HP:0002753)2.71917236
45Abnormality of the Achilles tendon (HP:0005109)2.70837016
46Myositis (HP:0100614)2.68440730
47Cervical subluxation (HP:0003308)2.64131525
48Large eyes (HP:0001090)2.63957403
49Apathy (HP:0000741)2.62963432
50Severe combined immunodeficiency (HP:0004430)2.62226714
51Abnormality of alanine metabolism (HP:0010916)2.60655905
52Hyperalaninemia (HP:0003348)2.60655905
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60655905
54Broad face (HP:0000283)2.60650544
55Myopathic facies (HP:0002058)2.59376540
56Recurrent sinusitis (HP:0011108)2.55461229
57Stridor (HP:0010307)2.54656427
58Ankle contracture (HP:0006466)2.51720250
59Abnormal neuron morphology (HP:0012757)2.51158439
60Abnormality of the motor neurons (HP:0002450)2.51158439
61Myokymia (HP:0002411)2.50606948
62Deep venous thrombosis (HP:0002625)2.47044670
63J-shaped sella turcica (HP:0002680)2.47004098
64Loss of speech (HP:0002371)2.46165260
65Nonimmune hydrops fetalis (HP:0001790)2.45846227
66Recurrent skin infections (HP:0001581)2.45825146
67Diminished motivation (HP:0000745)2.44666454
68Elbow flexion contracture (HP:0002987)2.42705884
69Cerebral aneurysm (HP:0004944)2.41561582
70Biconcave vertebral bodies (HP:0004586)2.40687388
71Palpebral edema (HP:0100540)2.36110862
72Distal lower limb amyotrophy (HP:0008944)2.35820365
73Spinal rigidity (HP:0003306)2.30988562
74Abnormality of B cell number (HP:0010975)2.30490795
75B lymphocytopenia (HP:0010976)2.30490795
76Genu recurvatum (HP:0002816)2.29871709
77Bladder diverticulum (HP:0000015)2.29834901
78Disproportionate tall stature (HP:0001519)2.29834392
79Iris hypopigmentation (HP:0007730)2.29765265
80Long toe (HP:0010511)2.29304864
81IgA deficiency (HP:0002720)2.28611465
82Rapidly progressive (HP:0003678)2.28231492
83Flat acetabular roof (HP:0003180)2.26933937
84Mildly elevated creatine phosphokinase (HP:0008180)2.24858663
85Blue sclerae (HP:0000592)2.23916857
86Patellar dislocation (HP:0002999)2.22322708
87Natal tooth (HP:0000695)2.20106214
88Progressive inability to walk (HP:0002505)2.17721383
89Absent/shortened dynein arms (HP:0200106)2.17719961
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.17719961
91Hyperparathyroidism (HP:0000843)2.16989879
92Long palpebral fissure (HP:0000637)2.16195179
93Gingivitis (HP:0000230)2.16117413
94Abnormality of the thoracic spine (HP:0100711)2.15975147
95Irregular vertebral endplates (HP:0003301)2.15888713
96Short nail (HP:0001799)2.13822514
97Increased connective tissue (HP:0009025)2.12341347
98Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12244336
99Distal upper limb amyotrophy (HP:0007149)2.11701875
100Upper limb amyotrophy (HP:0009129)2.11701875
101Acute necrotizing encephalopathy (HP:0006965)2.10450685
102Inability to walk (HP:0002540)2.10052597
103Insomnia (HP:0100785)2.10049899
104Advanced eruption of teeth (HP:0006288)2.08249273
105Abnormality of T cell physiology (HP:0011840)2.07855760
106Combined immunodeficiency (HP:0005387)2.07393277
107Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06766650
108Trismus (HP:0000211)2.05995091
109Generalized amyotrophy (HP:0003700)2.04102013
110Mitral regurgitation (HP:0001653)2.02595480
111Lipid accumulation in hepatocytes (HP:0006561)2.02474385
112Sparse lateral eyebrow (HP:0005338)2.01653213
113Centrally nucleated skeletal muscle fibers (HP:0003687)2.00389291
114Tubulointerstitial nephritis (HP:0001970)2.00377657
115Papilledema (HP:0001085)2.00329823
116Atrophic scars (HP:0001075)1.99719326
117Ocular albinism (HP:0001107)1.99516422
118Congenital glaucoma (HP:0001087)1.99452626
119Vascular tortuosity (HP:0004948)1.99214525
120Renal duplication (HP:0000075)1.99142301
121Rhabdomyolysis (HP:0003201)1.97420807
122Abnormality of the acetabulum (HP:0003170)1.96601341
123Aplastic anemia (HP:0001915)1.96303630
124Broad distal phalanx of finger (HP:0009836)1.96230237
125Hyperthyroidism (HP:0000836)1.95718204
126Recurrent abscess formation (HP:0002722)1.92483047
127Unilateral renal agenesis (HP:0000122)1.91761297
128Hallux valgus (HP:0001822)1.91730017
129Mitochondrial inheritance (HP:0001427)1.90372056
130Arterial tortuosity (HP:0005116)1.90259133
131Dysostosis multiplex (HP:0000943)1.88406772
132Spinal cord compression (HP:0002176)1.88329134
133Reticulocytosis (HP:0001923)1.88188711
134Elfin facies (HP:0004428)1.88091867
135Acute hepatic failure (HP:0006554)1.87534590
136Wormian bones (HP:0002645)1.86816502
137Prolonged bleeding time (HP:0003010)1.86496814
138Abnormality of the phalanges of the hallux (HP:0010057)1.86186820
139Abnormality of the tricuspid valve (HP:0001702)1.85340519
140Supranuclear gaze palsy (HP:0000605)1.85250450
141Breast hypoplasia (HP:0003187)1.84947658
142Progressive muscle weakness (HP:0003323)1.84888634
143Premature skin wrinkling (HP:0100678)1.84870487
144Adducted thumb (HP:0001181)1.84714145
145Abnormality of T cells (HP:0002843)1.84640265
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.84270139
147Abdominal distention (HP:0003270)1.84150795
148Albinism (HP:0001022)1.84091070
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.83528227
150Osteolytic defects of the hand bones (HP:0009699)1.83528227
151Bowing of the arm (HP:0006488)1.83285542
152Bowed forearm bones (HP:0003956)1.83285542
153Tetraplegia (HP:0002445)1.83173557
154Urinary glycosaminoglycan excretion (HP:0003541)1.83115827
155Mucopolysacchariduria (HP:0008155)1.83115827
156Deviation of the hallux (HP:0010051)1.82850593
157Increased variability in muscle fiber diameter (HP:0003557)1.82207885
158Abnormal mitochondria in muscle tissue (HP:0008316)1.82192364
159Germ cell neoplasia (HP:0100728)1.81922893
160Ankle clonus (HP:0011448)1.81285972
161Shallow orbits (HP:0000586)1.80427735
162Poor eye contact (HP:0000817)1.80331834
163Panhypogammaglobulinemia (HP:0003139)1.79987302
164Hemorrhage of the eye (HP:0011885)1.79916134
165Eczematoid dermatitis (HP:0000976)1.79746734
166Breech presentation (HP:0001623)1.79087911
167Lymphangioma (HP:0100764)1.78397098
168Venous abnormality (HP:0002624)1.78218386
169Abnormal ossification of hand bones (HP:0005921)1.78173123
170Abnormality of dentin (HP:0010299)1.76788969
171Aortic dissection (HP:0002647)1.76510897
172Hepatocellular necrosis (HP:0001404)1.76384201
173Acanthosis nigricans (HP:0000956)1.75715276
174Psychosis (HP:0000709)1.75222018
175Bronchitis (HP:0012387)1.74672688
176Hypertensive crisis (HP:0100735)1.73303997
177Back pain (HP:0003418)1.73199777
178Impaired smooth pursuit (HP:0007772)1.72637570
179Urethral obstruction (HP:0000796)1.72206554
180Generalized tonic-clonic seizures (HP:0002069)1.72027249
181Abnormality of the lower motor neuron (HP:0002366)1.71959179
182Abnormality of polysaccharide metabolism (HP:0011012)1.71764131
183Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71764131
184Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71764131
185Atonic seizures (HP:0010819)1.71690355
186Abnormalities of placenta or umbilical cord (HP:0001194)1.71580918
187Dyskinesia (HP:0100660)1.71475137
188Joint laxity (HP:0001388)1.71120867
189Dilatation of the ascending aorta (HP:0005111)1.69891903
190Inappropriate behavior (HP:0000719)1.69650582
191Short tibia (HP:0005736)1.69125099
192Multiple enchondromatosis (HP:0005701)1.67231481
193Gastrointestinal stroma tumor (HP:0100723)1.65766969
194Syncope (HP:0001279)1.65545502
195Acute encephalopathy (HP:0006846)1.64695910
196Abnormality of the anterior chamber (HP:0000593)1.63895890
197Pulmonary fibrosis (HP:0002206)1.62742639
198Petechiae (HP:0000967)1.61895567
199Depression (HP:0000716)1.61778198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K128.87814053
2TRIB36.02198531
3TESK25.14745601
4MAP4K14.97022691
5TESK13.83364842
6MAP3K113.48733177
7IRAK33.24027881
8ZAP703.22802785
9EPHA23.12067893
10NME23.05711736
11SCYL22.94367747
12SMG12.91805319
13LIMK12.84536354
14PKN22.69324303
15MYLK2.66467502
16KDR2.58598746
17ICK2.50243061
18ERN12.45909937
19PRPF4B2.45433610
20DAPK12.31538552
21CDK122.23996347
22STK241.90745192
23SIK31.83782092
24RPS6KB21.81360669
25TTN1.77500239
26TXK1.66326933
27MARK11.50945330
28TAOK21.50456395
29PDGFRA1.48344790
30SIK21.44331364
31MST1R1.43144693
32PIM21.38815440
33RIPK11.36400740
34MAP2K41.30965432
35PAK41.25871190
36FGFR11.24688793
37MAP2K21.24565344
38MINK11.17917958
39SYK1.16880806
40PRKD21.16085653
41MTOR1.14482980
42ARAF1.13525403
43PTK61.12725335
44EIF2AK11.11209715
45CDK81.11081187
46DAPK31.07655528
47PTK21.04952688
48CDK71.03257717
49RPS6KA21.02543676
50NTRK21.00856742
51NTRK30.99259763
52IRAK20.96881456
53LRRK20.91321871
54PDPK10.88759277
55FGFR40.87985657
56MUSK0.87610471
57MAP3K60.86619218
58MAP3K130.85878807
59EPHA40.85066324
60DDR20.83668073
61EIF2AK30.83316696
62ILK0.82913257
63MAPK110.79619556
64ITK0.78949175
65PDGFRB0.78872731
66GRK60.78101251
67LCK0.77247300
68TBK10.77100671
69VRK20.74713466
70MAP3K10.73451716
71PNCK0.72400937
72RPS6KC10.71160372
73RPS6KL10.71160372
74TYRO30.69397910
75MAP3K90.69159605
76CDC42BPA0.68783156
77MAP3K30.67541588
78MAP3K80.66461771
79PAK20.63917813
80MAP3K100.63633958
81MAP2K30.62424193
82CDK50.60094276
83KIT0.59603172
84BRAF0.58470941
85MET0.55965256
86HIPK20.55912979
87KSR10.55868421
88PRKCI0.55324204
89CDK40.54247817
90FYN0.54091740
91PRKG20.53615334
92TEC0.53026141
93CDK90.52954202
94MAP3K20.52628202
95MARK20.52016196
96AURKA0.51967933
97TLK10.51585909
98LMTK20.51364259
99CHUK0.50601961
100MAPKAPK20.49724019
101RPS6KA60.48471850
102NTRK10.48419141
103EEF2K0.46873330
104ROCK20.46624448
105MAP2K10.46474583
106UHMK10.45007080
107CAMK2G0.44879091
108FES0.44268817
109FGFR20.44212972
110ROCK10.41234287
111DAPK20.41136718
112CDK180.40856811
113AKT20.40703451
114MAP2K60.40600946
115CAMK10.39988455
116MAP2K70.39798209
117MAP3K50.38698155
118EPHB10.38121184
119BRSK10.38019641
120CDK150.36748086
121NEK10.36368145
122PRKCG0.36008573
123BCKDK0.34428596
124TAOK10.34391483
125IRAK40.34173171
126TSSK60.33968552
127EPHB20.33508485
128CHEK20.33236817
129DYRK20.33168669
130PRKCD0.33127037
131DYRK1B0.32166160
132DMPK0.31921281
133RPS6KA40.31056780
134PDK10.30432346
135SIK10.30272056
136HCK0.30112270
137PAK60.30009802
138MAP3K140.29341676
139CLK10.29284223
140SRC0.29224786
141BMX0.29178003
142LYN0.28913323
143PAK10.28624479
144IKBKB0.28483811
145CDK60.28168219
146CAMKK10.28152140
147CDK11A0.27605991
148RET0.27235700
149PRKCH0.26384644
150CDK140.25637603
151MAPKAPK30.22678459
152RAF10.21915394
153NME10.21822732
154LATS20.21042811
155INSR0.20762201
156VRK10.20514768
157ALK0.19791780
158CSF1R0.19439694
159CSK0.17834134
160ABL20.17488189
161PRKD10.16168460
162BLK0.15766376
163KSR20.15425543
164TNIK0.14958287
165CAMK2B0.13938522
166BUB10.13740619
167PRKD30.12209334
168PRKCB0.11999593
169PRKDC0.11506008
170CAMK2A0.10527043

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.80001653
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.08523986
3T cell receptor signaling pathway_Homo sapiens_hsa046602.90958550
4Other glycan degradation_Homo sapiens_hsa005112.89858877
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.74862286
6Hematopoietic cell lineage_Homo sapiens_hsa046402.69643326
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.59713870
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.52036315
9Synaptic vesicle cycle_Homo sapiens_hsa047212.50295159
10Bladder cancer_Homo sapiens_hsa052192.48455531
11Pentose phosphate pathway_Homo sapiens_hsa000302.41303942
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.33926175
13Chronic myeloid leukemia_Homo sapiens_hsa052202.17426789
14Central carbon metabolism in cancer_Homo sapiens_hsa052302.15980385
15Acute myeloid leukemia_Homo sapiens_hsa052212.10547224
16Notch signaling pathway_Homo sapiens_hsa043301.94368607
17Long-term potentiation_Homo sapiens_hsa047201.93405451
18Fructose and mannose metabolism_Homo sapiens_hsa000511.92062648
19Amphetamine addiction_Homo sapiens_hsa050311.90458252
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.88394694
21Circadian entrainment_Homo sapiens_hsa047131.77537759
22Non-small cell lung cancer_Homo sapiens_hsa052231.75730631
23Nicotine addiction_Homo sapiens_hsa050331.74411115
24Morphine addiction_Homo sapiens_hsa050321.70397770
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67909663
26Protein export_Homo sapiens_hsa030601.65107139
27Galactose metabolism_Homo sapiens_hsa000521.64789987
28VEGF signaling pathway_Homo sapiens_hsa043701.59608743
29Biosynthesis of amino acids_Homo sapiens_hsa012301.58531429
30Dopaminergic synapse_Homo sapiens_hsa047281.58455415
31Glutamatergic synapse_Homo sapiens_hsa047241.57849771
32Pancreatic cancer_Homo sapiens_hsa052121.55563492
33Olfactory transduction_Homo sapiens_hsa047401.52098653
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51786668
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46038964
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45448085
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44792688
38Endometrial cancer_Homo sapiens_hsa052131.43018137
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41935237
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40439063
41GABAergic synapse_Homo sapiens_hsa047271.39346473
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39273064
43Ribosome_Homo sapiens_hsa030101.38247884
44mTOR signaling pathway_Homo sapiens_hsa041501.37687986
45Cardiac muscle contraction_Homo sapiens_hsa042601.35017210
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34774924
47Focal adhesion_Homo sapiens_hsa045101.33662319
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33044236
49Sulfur relay system_Homo sapiens_hsa041221.32465568
50Vitamin B6 metabolism_Homo sapiens_hsa007501.27918210
51Small cell lung cancer_Homo sapiens_hsa052221.26283874
52Prion diseases_Homo sapiens_hsa050201.24608181
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23066699
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22306142
55Lysosome_Homo sapiens_hsa041421.21152715
56Oxytocin signaling pathway_Homo sapiens_hsa049211.18447816
57Base excision repair_Homo sapiens_hsa034101.18375514
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17870117
59Renin secretion_Homo sapiens_hsa049241.17451972
60Cocaine addiction_Homo sapiens_hsa050301.17039868
61Proteoglycans in cancer_Homo sapiens_hsa052051.17025726
62ECM-receptor interaction_Homo sapiens_hsa045121.16889243
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15642980
64Insulin secretion_Homo sapiens_hsa049111.14321494
65Glioma_Homo sapiens_hsa052141.13883550
66Insulin signaling pathway_Homo sapiens_hsa049101.12361033
67Salivary secretion_Homo sapiens_hsa049701.11795284
68DNA replication_Homo sapiens_hsa030301.11325135
69Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09935878
70AMPK signaling pathway_Homo sapiens_hsa041521.09745005
71Spliceosome_Homo sapiens_hsa030401.08290018
72Carbon metabolism_Homo sapiens_hsa012001.07415224
73Renal cell carcinoma_Homo sapiens_hsa052111.07383595
74Axon guidance_Homo sapiens_hsa043601.05651937
75Endocytosis_Homo sapiens_hsa041441.04499653
76Rap1 signaling pathway_Homo sapiens_hsa040151.04162837
77Calcium signaling pathway_Homo sapiens_hsa040201.01006049
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00776643
79Gastric acid secretion_Homo sapiens_hsa049711.00479821
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.99796855
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98077119
82MicroRNAs in cancer_Homo sapiens_hsa052060.97934432
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.97779354
84Alzheimers disease_Homo sapiens_hsa050100.97480479
85Hepatitis C_Homo sapiens_hsa051600.97457077
86Allograft rejection_Homo sapiens_hsa053300.95895252
87Amoebiasis_Homo sapiens_hsa051460.94892207
88Phenylalanine metabolism_Homo sapiens_hsa003600.94660351
89Parkinsons disease_Homo sapiens_hsa050120.94417897
90N-Glycan biosynthesis_Homo sapiens_hsa005100.94206496
91ErbB signaling pathway_Homo sapiens_hsa040120.94195324
92Hepatitis B_Homo sapiens_hsa051610.90688960
93Apoptosis_Homo sapiens_hsa042100.90240241
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89977543
95Oxidative phosphorylation_Homo sapiens_hsa001900.89360178
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89240377
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87683886
98Viral myocarditis_Homo sapiens_hsa054160.85148135
99Prostate cancer_Homo sapiens_hsa052150.83672351
100Glucagon signaling pathway_Homo sapiens_hsa049220.81968767
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80613464
102HTLV-I infection_Homo sapiens_hsa051660.80221859
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79773371
104Insulin resistance_Homo sapiens_hsa049310.79440540
105Dilated cardiomyopathy_Homo sapiens_hsa054140.79372478
106Folate biosynthesis_Homo sapiens_hsa007900.79000006
107Cholinergic synapse_Homo sapiens_hsa047250.78653341
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78047098
109Circadian rhythm_Homo sapiens_hsa047100.77235498
110Chemokine signaling pathway_Homo sapiens_hsa040620.75868562
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75847546
112Shigellosis_Homo sapiens_hsa051310.74895969
113Nitrogen metabolism_Homo sapiens_hsa009100.74844163
114Melanoma_Homo sapiens_hsa052180.73482579
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73214267
116Prolactin signaling pathway_Homo sapiens_hsa049170.73076568
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.72253582
118Alcoholism_Homo sapiens_hsa050340.70918896
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69605447
120Type I diabetes mellitus_Homo sapiens_hsa049400.69147326
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.68644590
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68501714
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.67986939
124Colorectal cancer_Homo sapiens_hsa052100.66688145
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66551391
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.66081730
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64977138
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64250050
129Systemic lupus erythematosus_Homo sapiens_hsa053220.63759874
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63616622
131Viral carcinogenesis_Homo sapiens_hsa052030.62738100
132Sphingolipid metabolism_Homo sapiens_hsa006000.62168139
133Hippo signaling pathway_Homo sapiens_hsa043900.61635629
134Oocyte meiosis_Homo sapiens_hsa041140.61427775
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59863869
136Huntingtons disease_Homo sapiens_hsa050160.59361955
137Lysine degradation_Homo sapiens_hsa003100.59045894
138TNF signaling pathway_Homo sapiens_hsa046680.58909762
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57255060
140Pyrimidine metabolism_Homo sapiens_hsa002400.55736407
141Collecting duct acid secretion_Homo sapiens_hsa049660.55350713
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55097683
143Osteoclast differentiation_Homo sapiens_hsa043800.55060046
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.54872692
145Salmonella infection_Homo sapiens_hsa051320.53993368
146Gap junction_Homo sapiens_hsa045400.53587345
147GnRH signaling pathway_Homo sapiens_hsa049120.52975149
148Glutathione metabolism_Homo sapiens_hsa004800.52967730
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52963246
150Inositol phosphate metabolism_Homo sapiens_hsa005620.52951352
151Estrogen signaling pathway_Homo sapiens_hsa049150.52510431
152B cell receptor signaling pathway_Homo sapiens_hsa046620.51970936
153p53 signaling pathway_Homo sapiens_hsa041150.51363567
154Arginine biosynthesis_Homo sapiens_hsa002200.50869992
155Basal cell carcinoma_Homo sapiens_hsa052170.50535034
156Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50336012
157HIF-1 signaling pathway_Homo sapiens_hsa040660.50273194
158Pathways in cancer_Homo sapiens_hsa052000.49850553
159Pertussis_Homo sapiens_hsa051330.48980921
160Leishmaniasis_Homo sapiens_hsa051400.47997833
161Homologous recombination_Homo sapiens_hsa034400.47777576
162Proteasome_Homo sapiens_hsa030500.47684970
163Choline metabolism in cancer_Homo sapiens_hsa052310.47441668
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47170265
165Platelet activation_Homo sapiens_hsa046110.46089233
166Type II diabetes mellitus_Homo sapiens_hsa049300.45268293
167Thyroid cancer_Homo sapiens_hsa052160.44488984
168Adherens junction_Homo sapiens_hsa045200.44488767
169Taste transduction_Homo sapiens_hsa047420.43545700
170cAMP signaling pathway_Homo sapiens_hsa040240.41904616
171Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41181021
172Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40327612
173Influenza A_Homo sapiens_hsa051640.40077984
174Toxoplasmosis_Homo sapiens_hsa051450.39730842
175cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35953415
176Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34557359
177Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34306453
178Vibrio cholerae infection_Homo sapiens_hsa051100.33838480
179Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33282937
180Pancreatic secretion_Homo sapiens_hsa049720.32889720

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