GJD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.50075255
2energy homeostasis (GO:0097009)6.68133867
3cornea development in camera-type eye (GO:0061303)6.13953471
4superoxide anion generation (GO:0042554)5.80744941
5regulation of hexokinase activity (GO:1903299)5.36726655
6regulation of glucokinase activity (GO:0033131)5.36726655
7DNA deamination (GO:0045006)4.72183850
8platelet dense granule organization (GO:0060155)4.57776879
9behavioral response to nicotine (GO:0035095)4.43623361
10detection of molecule of bacterial origin (GO:0032490)4.40197531
11centriole replication (GO:0007099)4.23147497
12response to host immune response (GO:0052572)4.09306438
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.09306438
14base-excision repair, AP site formation (GO:0006285)4.01995681
15positive regulation of cellular amide metabolic process (GO:0034250)3.97265885
16detection of other organism (GO:0098543)3.93339159
17positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.87443476
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.84486237
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.84486237
20modulation by symbiont of host immune response (GO:0052553)3.84486237
21positive regulation by symbiont of host defense response (GO:0052509)3.84486237
22modulation by symbiont of host defense response (GO:0052031)3.84486237
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.84486237
24detection of bacterium (GO:0016045)3.75030997
25phagocytosis, recognition (GO:0006910)3.74229687
26detection of external biotic stimulus (GO:0098581)3.73022089
27kinetochore assembly (GO:0051382)3.68723219
28preassembly of GPI anchor in ER membrane (GO:0016254)3.67559335
29regulation of development, heterochronic (GO:0040034)3.67146821
30piRNA metabolic process (GO:0034587)3.65220107
31sulfate transport (GO:0008272)3.64836589
32auditory receptor cell stereocilium organization (GO:0060088)3.64720942
33negative regulation of telomere maintenance (GO:0032205)3.61031296
34cytochrome complex assembly (GO:0017004)3.52965249
35mesenchymal cell differentiation involved in kidney development (GO:0072161)3.51615549
36mesenchymal cell differentiation involved in renal system development (GO:2001012)3.51615549
37L-fucose catabolic process (GO:0042355)3.49766688
38fucose catabolic process (GO:0019317)3.49766688
39L-fucose metabolic process (GO:0042354)3.49766688
40kinetochore organization (GO:0051383)3.48488699
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.47072812
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.44333853
43regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.42115747
44response to host (GO:0075136)3.36182966
45response to host defenses (GO:0052200)3.36182966
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.36182966
47cerebral cortex radially oriented cell migration (GO:0021799)3.33031426
48polyol transport (GO:0015791)3.28907205
49positive regulation of mitochondrial fission (GO:0090141)3.28319158
50neural tube formation (GO:0001841)3.27353738
51negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.24680199
52DNA double-strand break processing (GO:0000729)3.23680063
53detection of biotic stimulus (GO:0009595)3.23482661
54detection of light stimulus involved in sensory perception (GO:0050962)3.22402504
55detection of light stimulus involved in visual perception (GO:0050908)3.22402504
56positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.13341073
57positive regulation of cell fate commitment (GO:0010455)3.11952807
58epithelial cilium movement (GO:0003351)3.11137223
59positive regulation of prostaglandin secretion (GO:0032308)3.10729011
60regulation of interleukin-8 secretion (GO:2000482)3.09894009
61extracellular regulation of signal transduction (GO:1900115)3.09616082
62extracellular negative regulation of signal transduction (GO:1900116)3.09616082
63response to peptidoglycan (GO:0032494)3.08167543
64T-helper 1 type immune response (GO:0042088)3.08037955
65histone H2B ubiquitination (GO:0033523)3.07830840
66estrogen biosynthetic process (GO:0006703)3.05284655
67positive regulation of interleukin-1 beta secretion (GO:0050718)3.04249363
68protein heterotetramerization (GO:0051290)3.03719735
69superoxide metabolic process (GO:0006801)3.03083542
70DNA methylation involved in gamete generation (GO:0043046)3.02472492
71photoreceptor cell development (GO:0042461)3.02457311
72regulation of cellular extravasation (GO:0002691)2.97340464
73positive regulation of defense response to virus by host (GO:0002230)2.96474407
74oligosaccharide catabolic process (GO:0009313)2.95039520
75mitotic cell cycle arrest (GO:0071850)2.94697152
76negative regulation of mast cell activation (GO:0033004)2.94128498
77polyketide metabolic process (GO:0030638)2.94085738
78doxorubicin metabolic process (GO:0044598)2.94085738
79daunorubicin metabolic process (GO:0044597)2.94085738
80microglial cell activation (GO:0001774)2.94058307
81indolalkylamine metabolic process (GO:0006586)2.93918584
82protein complex biogenesis (GO:0070271)2.93597775
83indole-containing compound catabolic process (GO:0042436)2.93226380
84indolalkylamine catabolic process (GO:0046218)2.93226380
85tryptophan catabolic process (GO:0006569)2.93226380
86wound healing, spreading of cells (GO:0044319)2.92283154
87positive regulation of fatty acid transport (GO:2000193)2.92128337
88kynurenine metabolic process (GO:0070189)2.91423452
89wound healing, spreading of epidermal cells (GO:0035313)2.90901827
90response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.90587442
91positive regulation of CREB transcription factor activity (GO:0032793)2.88288425
92male meiosis (GO:0007140)2.87420901
93positive regulation of T cell migration (GO:2000406)2.85749489
94keratinocyte development (GO:0003334)2.85636413
95photoreceptor cell maintenance (GO:0045494)2.85522477
96chaperone-mediated protein transport (GO:0072321)2.84764732
97ubiquinone metabolic process (GO:0006743)2.84658782
98behavioral response to ethanol (GO:0048149)2.82965553
99axoneme assembly (GO:0035082)2.82445944
100regulation of skeletal muscle fiber development (GO:0048742)2.82280332
101protein polyglutamylation (GO:0018095)2.82056251
102negative regulation of cAMP-mediated signaling (GO:0043951)2.81882337
103mesenchymal cell differentiation (GO:0048762)2.81101371
104tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80443672
105RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80443672
106female gonad development (GO:0008585)2.80311655
107positive regulation of interleukin-1 secretion (GO:0050716)2.78157932
108dopamine transport (GO:0015872)2.77040350
109inner ear receptor stereocilium organization (GO:0060122)2.76421279
110cilium morphogenesis (GO:0060271)2.75576331
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.74069992
112NADH dehydrogenase complex assembly (GO:0010257)2.74069992
113mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74069992
114hindbrain development (GO:0030902)2.73675437
115protein-cofactor linkage (GO:0018065)2.73298733
116GPI anchor metabolic process (GO:0006505)2.72814300
117regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70478348
118retinal cone cell development (GO:0046549)2.69815939
119rhodopsin mediated signaling pathway (GO:0016056)2.69749810
120positive regulation of heat generation (GO:0031652)2.69234902
121synaptic transmission, cholinergic (GO:0007271)2.68363097
122G-protein coupled receptor internalization (GO:0002031)2.67201998
123androgen biosynthetic process (GO:0006702)2.67077776
124positive regulation of icosanoid secretion (GO:0032305)2.66244180
125purine deoxyribonucleotide catabolic process (GO:0009155)2.65409937
126respiratory chain complex IV assembly (GO:0008535)2.65389783
127eye photoreceptor cell development (GO:0042462)2.65154878
128protein localization to cilium (GO:0061512)2.63955712
129positive regulation of T cell mediated cytotoxicity (GO:0001916)2.63632833
130negative regulation of myoblast differentiation (GO:0045662)2.63610908
131cell wall macromolecule catabolic process (GO:0016998)2.63283461
132phosphatidylglycerol biosynthetic process (GO:0006655)2.61856639
133meiotic chromosome segregation (GO:0045132)2.61169190
134positive regulation of histone deacetylation (GO:0031065)2.59966477
135multicellular organism reproduction (GO:0032504)2.58767584
136centriole assembly (GO:0098534)2.58439885
137leukocyte aggregation (GO:0070486)2.58029612
138positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.57358330
139pseudouridine synthesis (GO:0001522)2.56858628
140regulation of interleukin-1 beta secretion (GO:0050706)2.56174814
141mitochondrial respiratory chain complex assembly (GO:0033108)2.55505649
142water-soluble vitamin biosynthetic process (GO:0042364)2.55118299
143synapsis (GO:0007129)2.52878154
144sulfation (GO:0051923)2.52713919
145C-terminal protein lipidation (GO:0006501)2.52244662
146facial nerve structural organization (GO:0021612)2.52020790
147pattern specification involved in kidney development (GO:0061004)2.51398217
148lipopolysaccharide biosynthetic process (GO:0009103)2.51166682
149male meiosis I (GO:0007141)2.50897069
150protein K11-linked deubiquitination (GO:0035871)2.50356299
151lipopolysaccharide metabolic process (GO:0008653)2.50225134
152somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48937289
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48937289
154isotype switching (GO:0045190)2.48937289
155signal transduction involved in regulation of gene expression (GO:0023019)2.48906646
156reciprocal DNA recombination (GO:0035825)2.48705528
157reciprocal meiotic recombination (GO:0007131)2.48705528
158one-carbon compound transport (GO:0019755)2.48462783
159aggressive behavior (GO:0002118)2.46600805
160cell differentiation involved in metanephros development (GO:0072202)2.45481565
161somite development (GO:0061053)2.45394068
162embryonic skeletal joint morphogenesis (GO:0060272)2.45260494
163negative regulation of myeloid cell apoptotic process (GO:0033033)2.44501554
164quinone biosynthetic process (GO:1901663)2.44344472
165ubiquinone biosynthetic process (GO:0006744)2.44344472
166mesenchymal-epithelial cell signaling (GO:0060638)2.44292743
167adenosine metabolic process (GO:0046085)2.43992890
168positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.43673596
169positive regulation of lymphocyte migration (GO:2000403)2.43555969
170tRNA processing (GO:0008033)2.43316008
171regulation of T cell migration (GO:2000404)2.42866339
172RNA destabilization (GO:0050779)2.42682448
173cellular response to ATP (GO:0071318)2.42623222
174protein deneddylation (GO:0000338)2.42567477
175mesonephros development (GO:0001823)2.42474006
176embryonic epithelial tube formation (GO:0001838)2.41803006
177regulation of neurotransmitter uptake (GO:0051580)2.41416440
178positive regulation of T cell chemotaxis (GO:0010820)2.41121176
179regulation of T cell chemotaxis (GO:0010819)2.41121176
180import into cell (GO:0098657)2.41060037
181positive regulation of organic acid transport (GO:0032892)2.40294485
182limb bud formation (GO:0060174)2.39765399
183GPI anchor biosynthetic process (GO:0006506)2.39553874
184cellular response to interferon-beta (GO:0035458)2.39131992
185mannosylation (GO:0097502)2.38939170
186regulation of timing of cell differentiation (GO:0048505)2.36996418
187regulation of chemokine secretion (GO:0090196)2.35157103
188regulation of NIK/NF-kappaB signaling (GO:1901222)2.34725875
189generation of neurons (GO:0048699)2.34448392
190G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.33510326
191negative regulation of keratinocyte proliferation (GO:0010839)2.33479778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.83543477
2ZNF274_21170338_ChIP-Seq_K562_Hela3.82309273
3GBX2_23144817_ChIP-Seq_PC3_Human3.17396904
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.88685409
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.74601239
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51696806
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51099585
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.42744219
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.39726308
10NFE2_27457419_Chip-Seq_LIVER_Mouse2.32236722
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.30099729
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23105294
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.22710137
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21379704
15FUS_26573619_Chip-Seq_HEK293_Human2.21341166
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.16840741
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02474617
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01427920
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.98454544
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98183885
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92596608
22EZH2_22144423_ChIP-Seq_EOC_Human1.92420981
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.91907867
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.91340605
25IRF1_19129219_ChIP-ChIP_H3396_Human1.90270835
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88975395
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.86420142
28EWS_26573619_Chip-Seq_HEK293_Human1.82344135
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.81875522
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.81204832
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81110500
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.80287424
33TP53_22573176_ChIP-Seq_HFKS_Human1.78849933
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.77377972
35P53_22387025_ChIP-Seq_ESCs_Mouse1.77252750
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75803245
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75110406
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.73816455
39NMYC_18555785_Chip-Seq_ESCs_Mouse1.73419011
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.69353631
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69161520
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.68577945
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67930940
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.67088366
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65498149
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65023488
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64306677
48MYC_18940864_ChIP-ChIP_HL60_Human1.63342797
49VDR_22108803_ChIP-Seq_LS180_Human1.63145938
50BCAT_22108803_ChIP-Seq_LS180_Human1.62831541
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62743633
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61716486
53P300_18555785_Chip-Seq_ESCs_Mouse1.60973731
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60100685
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60100685
56OCT4_18555785_Chip-Seq_ESCs_Mouse1.59843941
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.59681313
58RUNX1_27457419_Chip-Seq_LIVER_Mouse1.57498081
59IGF1R_20145208_ChIP-Seq_DFB_Human1.57135797
60SOX2_19829295_ChIP-Seq_ESCs_Human1.56574036
61NANOG_19829295_ChIP-Seq_ESCs_Human1.56574036
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.55994759
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.55368403
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54276891
65PU1_27457419_Chip-Seq_LIVER_Mouse1.52288399
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.51685584
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50795062
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49837255
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.49623769
70KLF4_18555785_Chip-Seq_ESCs_Mouse1.48729778
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48037364
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47083452
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.46830635
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46830635
75ESRRB_18555785_Chip-Seq_ESCs_Mouse1.46316412
76P300_19829295_ChIP-Seq_ESCs_Human1.46156895
77* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45869598
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45602673
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45486582
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44991325
81CBP_20019798_ChIP-Seq_JUKART_Human1.43135768
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43135768
83SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43123402
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42125922
85GATA1_22025678_ChIP-Seq_K562_Human1.41955545
86CTCF_18555785_Chip-Seq_ESCs_Mouse1.41894681
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40233588
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39635866
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39598178
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.37568892
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.37455854
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36862697
93TP53_18474530_ChIP-ChIP_U2OS_Human1.36252047
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36150877
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36013145
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35524857
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34739184
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.34612230
99AR_20517297_ChIP-Seq_VCAP_Human1.34194993
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.34123221
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.33715341
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33645892
103KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33372567
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33110927
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33092240
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31808906
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31699925
108STAT3_23295773_ChIP-Seq_U87_Human1.31133849
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30842254
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29032973
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27665510
112VDR_23849224_ChIP-Seq_CD4+_Human1.27404513
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27260346
114RNF2_27304074_Chip-Seq_ESCs_Mouse1.26183633
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25616009
116SRF_21415370_ChIP-Seq_HL-1_Mouse1.24571703
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23642216
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.23531845
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22717436
120IRF8_27001747_Chip-Seq_BMDM_Mouse1.22140790
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21250523
122TRIM28_21343339_ChIP-Seq_HEK293_Human1.21209012
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20508604
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20489182
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.19860700
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.19233007
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18740658
128HOXB7_26014856_ChIP-Seq_BT474_Human1.18658786
129SMAD4_21799915_ChIP-Seq_A2780_Human1.18277309
130AR_25329375_ChIP-Seq_VCAP_Human1.18273615
131DROSHA_22980978_ChIP-Seq_HELA_Human1.18047099
132FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17934706
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17600503
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.16097924
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.15873381
136ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15717285
137ELK1_19687146_ChIP-ChIP_HELA_Human1.15403025
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15349282
139SCL_19346495_ChIP-Seq_HPC-7_Human1.13425690
140TCF4_22108803_ChIP-Seq_LS180_Human1.13171491
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12193530
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12193530
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12104604
144SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10726068
145GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10591269
146HTT_18923047_ChIP-ChIP_STHdh_Human1.10552221
147RUNX2_22187159_ChIP-Seq_PCA_Human1.09137660
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08147919
149ER_23166858_ChIP-Seq_MCF-7_Human1.07580863
150TP63_19390658_ChIP-ChIP_HaCaT_Human1.07268226
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06473210
152RNF2_27304074_Chip-Seq_NSC_Mouse1.06033435
153TAF15_26573619_Chip-Seq_HEK293_Human1.05114190
154MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04883568
155ESR1_21235772_ChIP-Seq_MCF-7_Human1.04347886
156NCOR_22424771_ChIP-Seq_293T_Human1.03840228
157MYC_19829295_ChIP-Seq_ESCs_Human1.02566844
158FOXP3_21729870_ChIP-Seq_TREG_Human1.02557966
159POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01579201
160* NANOG_20526341_ChIP-Seq_ESCs_Human1.01148850
161TCF4_23295773_ChIP-Seq_U87_Human1.01083226
162CDX2_22108803_ChIP-Seq_LS180_Human1.00974693
163FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98412904
164JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96516498
165ETS1_20019798_ChIP-Seq_JURKAT_Human0.94666932
166CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94620702
167PRDM14_20953172_ChIP-Seq_ESCs_Human0.93828427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.47743345
2MP0009697_abnormal_copulation3.51187493
3MP0000383_abnormal_hair_follicle3.50020305
4MP0005083_abnormal_biliary_tract3.24245097
5MP0001188_hyperpigmentation2.99159965
6MP0003941_abnormal_skin_development2.88964730
7MP0008057_abnormal_DNA_replication2.88455480
8MP0004782_abnormal_surfactant_physiolog2.86001064
9MP0003724_increased_susceptibility_to2.77561071
10MP0006292_abnormal_olfactory_placode2.71148352
11MP0001835_abnormal_antigen_presentation2.70041556
12MP0005503_abnormal_tendon_morphology2.67829795
13MP0002102_abnormal_ear_morphology2.60605884
14MP0002277_abnormal_respiratory_mucosa2.57024548
15MP0005451_abnormal_body_composition2.48542798
16MP0003136_yellow_coat_color2.45267002
17MP0002148_abnormal_hypersensitivity_rea2.44115598
18MP0008789_abnormal_olfactory_epithelium2.26423858
19MP0001879_abnormal_lymphatic_vessel2.24103160
20MP0005551_abnormal_eye_electrophysiolog2.23935589
21MP0008875_abnormal_xenobiotic_pharmacok2.15217963
22MP0001968_abnormal_touch/_nociception2.11426264
23MP0008260_abnormal_autophagy2.10692537
24MP0002419_abnormal_innate_immunity2.10439560
25MP0009785_altered_susceptibility_to1.98829095
26MP0003252_abnormal_bile_duct1.95004025
27MP0009764_decreased_sensitivity_to1.93092293
28MP0003787_abnormal_imprinting1.91441397
29MP0008872_abnormal_physiological_respon1.90187931
30MP0002837_dystrophic_cardiac_calcinosis1.89545864
31MP0003121_genomic_imprinting1.88325783
32MP0000566_synostosis1.84086289
33MP0003828_pulmonary_edema1.81385661
34MP0005085_abnormal_gallbladder_physiolo1.79881890
35MP0002160_abnormal_reproductive_system1.79171561
36MP0006072_abnormal_retinal_apoptosis1.78871776
37MP0008004_abnormal_stomach_pH1.77719879
38MP0005410_abnormal_fertilization1.74407316
39MP0005646_abnormal_pituitary_gland1.71640795
40MP0005394_taste/olfaction_phenotype1.69477205
41MP0005499_abnormal_olfactory_system1.69477205
42MP0010678_abnormal_skin_adnexa1.68370330
43MP0005171_absent_coat_pigmentation1.65638713
44MP0003385_abnormal_body_wall1.65405820
45MP0004147_increased_porphyrin_level1.65327050
46MP0005025_abnormal_response_to1.64855643
47MP0002876_abnormal_thyroid_physiology1.61433838
48MP0000490_abnormal_crypts_of1.59214956
49MP0003880_abnormal_central_pattern1.57838766
50MP0002396_abnormal_hematopoietic_system1.54339647
51MP0004043_abnormal_pH_regulation1.54217002
52MP0004019_abnormal_vitamin_homeostasis1.49736445
53MP0002132_abnormal_respiratory_system1.48217191
54MP0005000_abnormal_immune_tolerance1.48162381
55MP0003938_abnormal_ear_development1.47211130
56MP0005365_abnormal_bile_salt1.46108574
57MP0005389_reproductive_system_phenotype1.45315655
58MP0000678_abnormal_parathyroid_gland1.45184193
59MP0005253_abnormal_eye_physiology1.44794274
60MP0001529_abnormal_vocalization1.41379040
61MP0005409_darkened_coat_color1.39548654
62MP0002723_abnormal_immune_serum1.37842075
63MP0003011_delayed_dark_adaptation1.37652636
64MP0002452_abnormal_antigen_presenting1.37506836
65MP0002272_abnormal_nervous_system1.36355663
66MP0004885_abnormal_endolymph1.35081560
67MP0001790_abnormal_immune_system1.34434089
68MP0005387_immune_system_phenotype1.34434089
69MP0003436_decreased_susceptibility_to1.32575374
70MP0001919_abnormal_reproductive_system1.30748975
71MP0001764_abnormal_homeostasis1.30519658
72MP0004510_myositis1.29818907
73MP0002254_reproductive_system_inflammat1.29393876
74MP0004742_abnormal_vestibular_system1.29136400
75MP0003195_calcinosis1.29114879
76MP0005379_endocrine/exocrine_gland_phen1.27064529
77MP0009250_abnormal_appendicular_skeleto1.25930908
78MP0003718_maternal_effect1.25503510
79MP0009745_abnormal_behavioral_response1.24733742
80MP0008995_early_reproductive_senescence1.23734851
81MP0006082_CNS_inflammation1.23338668
82MP0001501_abnormal_sleep_pattern1.23066279
83MP0001984_abnormal_olfaction1.22415213
84MP0000762_abnormal_tongue_morphology1.22350147
85MP0003122_maternal_imprinting1.21390088
86MP0004484_altered_response_of1.20246485
87MP0004381_abnormal_hair_follicle1.18180899
88MP0002098_abnormal_vibrissa_morphology1.17930244
89MP0002735_abnormal_chemical_nociception1.11738816
90MP0004133_heterotaxia1.11546762
91MP0000026_abnormal_inner_ear1.11476373
92MP0001800_abnormal_humoral_immune1.11072035
93MP0004142_abnormal_muscle_tone1.10485556
94MP0006276_abnormal_autonomic_nervous1.10155697
95MP0002928_abnormal_bile_duct1.10045177
96MP0002163_abnormal_gland_morphology1.09846602
97MP0001819_abnormal_immune_cell1.08487283
98MP0000613_abnormal_salivary_gland1.08344823
99MP0001986_abnormal_taste_sensitivity1.04789879
100MP0002420_abnormal_adaptive_immunity1.04503755
101MP0005084_abnormal_gallbladder_morpholo1.03323035
102MP0005645_abnormal_hypothalamus_physiol1.02398584
103MP0002234_abnormal_pharynx_morphology1.01740054
104MP0001905_abnormal_dopamine_level1.01498996
105MP0000631_abnormal_neuroendocrine_gland1.01347819
106MP0005671_abnormal_response_to1.00949237
107MP0003950_abnormal_plasma_membrane1.00707871
108MP0001853_heart_inflammation1.00529732
109MP0000372_irregular_coat_pigmentation1.00447065
110MP0001346_abnormal_lacrimal_gland0.99768059
111MP0002733_abnormal_thermal_nociception0.97516526
112MP0009046_muscle_twitch0.94660668
113MP0000767_abnormal_smooth_muscle0.94192840
114MP0005670_abnormal_white_adipose0.93711169
115MP0005167_abnormal_blood-brain_barrier0.93158215
116MP0010386_abnormal_urinary_bladder0.91478174
117MP0005464_abnormal_platelet_physiology0.91134243
118MP0001502_abnormal_circadian_rhythm0.90941550
119MP0000579_abnormal_nail_morphology0.90831642
120MP0009384_cardiac_valve_regurgitation0.90256820
121MP0002998_abnormal_bone_remodeling0.89664383
122MP0002109_abnormal_limb_morphology0.89552912
123MP0003698_abnormal_male_reproductive0.89383861
124MP0001963_abnormal_hearing_physiology0.89102177
125MP0005386_behavior/neurological_phenoty0.86867113
126MP0004924_abnormal_behavior0.86867113
127MP0001191_abnormal_skin_condition0.86705725
128MP0005367_renal/urinary_system_phenotyp0.86461586
129MP0000516_abnormal_urinary_system0.86461586
130MP0002938_white_spotting0.85351447
131MP0002249_abnormal_larynx_morphology0.84227799
132MP0000343_altered_response_to0.84181857
133MP0002115_abnormal_skeleton_extremities0.83884315
134MP0010329_abnormal_lipoprotein_level0.83233997
135MP0010155_abnormal_intestine_physiology0.83102958
136MP0002572_abnormal_emotion/affect_behav0.82921688
137MP0001929_abnormal_gametogenesis0.82819316
138MP0000627_abnormal_mammary_gland0.82389745
139MP0008961_abnormal_basal_metabolism0.81340664
140MP0000230_abnormal_systemic_arterial0.80446639
141MP0005332_abnormal_amino_acid0.80018426
142MP0001970_abnormal_pain_threshold0.79963374
143MP0002557_abnormal_social/conspecific_i0.78668289
144MP0000015_abnormal_ear_pigmentation0.78333776
145MP0005195_abnormal_posterior_eye0.77190840
146MP0002210_abnormal_sex_determination0.76124190
147MP0003786_premature_aging0.75202608
148MP0001486_abnormal_startle_reflex0.74855498
149MP0000653_abnormal_sex_gland0.74532440
150MP0000427_abnormal_hair_cycle0.74438749
151MP0005257_abnormal_intraocular_pressure0.74355151
152MP0003646_muscle_fatigue0.74208859
153MP0008058_abnormal_DNA_repair0.72759070
154MP0002751_abnormal_autonomic_nervous0.71523453
155MP0001119_abnormal_female_reproductive0.70823404
156MP0001845_abnormal_inflammatory_respons0.70746988
157MP0002108_abnormal_muscle_morphology0.70437673
158MP0002736_abnormal_nociception_after0.68515407
159MP0001944_abnormal_pancreas_morphology0.67383094
160MP0005390_skeleton_phenotype0.67348238
161MP0002752_abnormal_somatic_nervous0.67107637
162MP0005174_abnormal_tail_pigmentation0.66342372
163MP0002177_abnormal_outer_ear0.66259872
164MP0002693_abnormal_pancreas_physiology0.65825930
165MP0006036_abnormal_mitochondrial_physio0.65279783
166MP0001177_atelectasis0.65151335
167MP0002090_abnormal_vision0.64423585
168MP0002653_abnormal_ependyma_morphology0.63842041
169MP0002932_abnormal_joint_morphology0.63683477
170MP0002184_abnormal_innervation0.63577091
171MP0000716_abnormal_immune_system0.63081433
172MP0003183_abnormal_peptide_metabolism0.61872930
173MP0002638_abnormal_pupillary_reflex0.61612149
174MP0000049_abnormal_middle_ear0.60503089

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.64450736
2Chromsome breakage (HP:0040012)4.91739923
3Febrile seizures (HP:0002373)4.90607782
4Prostate neoplasm (HP:0100787)4.87887286
5Hypoplasia of the fovea (HP:0007750)4.67965141
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.67965141
7Type II lissencephaly (HP:0007260)4.35274283
8Fetal akinesia sequence (HP:0001989)4.08438565
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.99737589
10Abnormality of the fovea (HP:0000493)3.91784679
11Pancreatic cysts (HP:0001737)3.78280334
12Upper limb muscle weakness (HP:0003484)3.65370912
13Eczematoid dermatitis (HP:0000976)3.60867109
14Septo-optic dysplasia (HP:0100842)3.53548521
15Abnormal rod and cone electroretinograms (HP:0008323)3.41893434
16True hermaphroditism (HP:0010459)3.36049996
17Abnormality of the renal cortex (HP:0011035)3.33782691
18Molar tooth sign on MRI (HP:0002419)3.20993486
19Abnormality of midbrain morphology (HP:0002418)3.20993486
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15061157
21Aplasia cutis congenita (HP:0001057)3.13826091
22Recurrent abscess formation (HP:0002722)3.10891408
23Pancreatic fibrosis (HP:0100732)3.09621711
24Attenuation of retinal blood vessels (HP:0007843)3.06511300
25Retinal dysplasia (HP:0007973)3.06009210
26Hyperventilation (HP:0002883)3.05264283
27Parakeratosis (HP:0001036)3.01988409
28Optic neuritis (HP:0100653)2.96062390
29Retrobulbar optic neuritis (HP:0100654)2.96062390
30Pustule (HP:0200039)2.95372329
31Medial flaring of the eyebrow (HP:0010747)2.94088355
32Nephronophthisis (HP:0000090)2.86327184
33Aplasia/Hypoplasia of the macula (HP:0008059)2.84855730
34Mediastinal lymphadenopathy (HP:0100721)2.82534459
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.72194840
36Inability to walk (HP:0002540)2.70854060
37Abnormality of the renal medulla (HP:0100957)2.70657588
38Abnormality of the prostate (HP:0008775)2.66889398
39Aplasia/Hypoplasia affecting the retina (HP:0008061)2.65245521
40Stomach cancer (HP:0012126)2.62811121
41Recurrent gram-negative bacterial infections (HP:0005420)2.60773380
42Decreased central vision (HP:0007663)2.59262704
43White forelock (HP:0002211)2.59106191
44Cerebellar dysplasia (HP:0007033)2.58760633
45Lissencephaly (HP:0001339)2.54177812
46Mitochondrial inheritance (HP:0001427)2.53595568
47Tubular atrophy (HP:0000092)2.53372400
48Abnormality of incisor morphology (HP:0011063)2.50391434
49Congenital sensorineural hearing impairment (HP:0008527)2.49418048
50Meckel diverticulum (HP:0002245)2.49218456
51Increased CSF lactate (HP:0002490)2.48573218
52Chronic obstructive pulmonary disease (HP:0006510)2.48312415
53Obstructive lung disease (HP:0006536)2.48312415
54Lipid accumulation in hepatocytes (HP:0006561)2.44583121
55Recurrent bacterial skin infections (HP:0005406)2.40597936
56Distal lower limb muscle weakness (HP:0009053)2.36874585
57Acute necrotizing encephalopathy (HP:0006965)2.34085371
58Abnormal drinking behavior (HP:0030082)2.30929799
59Polydipsia (HP:0001959)2.30929799
60Popliteal pterygium (HP:0009756)2.30923477
61Abnormal respiratory motile cilium physiology (HP:0012261)2.30840787
62Mesomelia (HP:0003027)2.30839103
63Thick nail (HP:0001805)2.29239291
64Patchy hypopigmentation of hair (HP:0011365)2.28820260
65Optic nerve hypoplasia (HP:0000609)2.28548841
66Petechiae (HP:0000967)2.28513244
67Joint hemorrhage (HP:0005261)2.27328888
68Orchitis (HP:0100796)2.25927849
69Abolished electroretinogram (ERG) (HP:0000550)2.25329472
70Abnormality of the ileum (HP:0001549)2.25299456
71Bony spicule pigmentary retinopathy (HP:0007737)2.24632507
72Chronic hepatic failure (HP:0100626)2.23763789
73Metaphyseal irregularity (HP:0003025)2.23542299
74Increased hepatocellular lipid droplets (HP:0006565)2.23259489
75Polyuria (HP:0000103)2.22940721
76Pulmonary artery stenosis (HP:0004415)2.22736439
77Abnormality of the preputium (HP:0100587)2.22161019
78Progressive microcephaly (HP:0000253)2.21001365
79Cheilitis (HP:0100825)2.19959273
80Aplastic anemia (HP:0001915)2.18282507
81Cystic liver disease (HP:0006706)2.16739723
82Gait imbalance (HP:0002141)2.16639553
83Recurrent pneumonia (HP:0006532)2.14948287
84Neoplasm of the tracheobronchial system (HP:0100552)2.14109513
85Congenital primary aphakia (HP:0007707)2.14022410
86Hepatic necrosis (HP:0002605)2.13081512
87Progressive macrocephaly (HP:0004481)2.13023859
88Vasculitis (HP:0002633)2.12891786
89Progressive inability to walk (HP:0002505)2.12847853
90Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12458332
91Generalized tonic-clonic seizures (HP:0002069)2.12266061
92Hepatocellular necrosis (HP:0001404)2.10931127
93Keratoconus (HP:0000563)2.10624834
94Increased corneal curvature (HP:0100692)2.10624834
95Abnormal mitochondria in muscle tissue (HP:0008316)2.10179871
96Pendular nystagmus (HP:0012043)2.10000630
97Onycholysis (HP:0001806)2.09828891
98Xerostomia (HP:0000217)2.09772145
99Alveolar cell carcinoma (HP:0006519)2.08641597
100Abnormal biliary tract physiology (HP:0012439)2.08208735
101Bile duct proliferation (HP:0001408)2.08208735
102Congenital stationary night blindness (HP:0007642)2.07361550
103Purpura (HP:0000979)2.06568107
104Ketoacidosis (HP:0001993)2.05821745
105Aplasia/Hypoplasia of the uvula (HP:0010293)2.05414329
106Increased IgM level (HP:0003496)2.03643301
107Nephroblastoma (Wilms tumor) (HP:0002667)2.02809505
108Meningitis (HP:0001287)2.02805083
109Aplasia of the musculature (HP:0100854)2.00826318
110Acute encephalopathy (HP:0006846)2.00338396
111Neonatal respiratory distress (HP:0002643)1.99924470
112Abnormal ciliary motility (HP:0012262)1.99863436
113Morphological abnormality of the middle ear (HP:0008609)1.98792803
114Arthropathy (HP:0003040)1.98603562
115Chronic mucocutaneous candidiasis (HP:0002728)1.98517102
116Recurrent cutaneous fungal infections (HP:0011370)1.98517102
117Clubbing of toes (HP:0100760)1.97888789
118Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.96222876
119Autoimmune thrombocytopenia (HP:0001973)1.94719606
120Absent speech (HP:0001344)1.94369203
121Premature loss of primary teeth (HP:0006323)1.92932623
122Myositis (HP:0100614)1.92471685
123Broad-based gait (HP:0002136)1.91871175
124Methylmalonic aciduria (HP:0012120)1.91819141
125Optic disc pallor (HP:0000543)1.91109634
126Nephrogenic diabetes insipidus (HP:0009806)1.90463891
127Male pseudohermaphroditism (HP:0000037)1.90267967
128Abnormality of the nasal septum (HP:0000419)1.89543801
129Abnormal sex determination (HP:0012244)1.89222960
130Sex reversal (HP:0012245)1.89222960
131Type 2 muscle fiber atrophy (HP:0003554)1.89098844
132Embryonal renal neoplasm (HP:0011794)1.87933815
133Corneal dystrophy (HP:0001131)1.87737247
134Neoplasm of the adrenal cortex (HP:0100641)1.87719123
135Severe Myopia (HP:0011003)1.87006856
136Duplicated collecting system (HP:0000081)1.86844502
137Absent septum pellucidum (HP:0001331)1.86844371
138Distal lower limb amyotrophy (HP:0008944)1.86419968
139Unilateral renal agenesis (HP:0000122)1.86200602
140Renal cortical cysts (HP:0000803)1.85377436
141Absent/shortened dynein arms (HP:0200106)1.85186861
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.85186861
143Hypokalemic alkalosis (HP:0001949)1.84678605
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.84298364
145Intestinal atresia (HP:0011100)1.84097858
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.83393418
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.82519140
148Congenital hepatic fibrosis (HP:0002612)1.82059639
149Recurrent sinusitis (HP:0011108)1.81845001
150Conical tooth (HP:0000698)1.81841594
151Hypothermia (HP:0002045)1.81596444
152Cerebral edema (HP:0002181)1.80838057
153Abnormality of macular pigmentation (HP:0008002)1.79981794
154Optic nerve coloboma (HP:0000588)1.79247729
155Clumsiness (HP:0002312)1.78596325
156Abnormal respiratory epithelium morphology (HP:0012253)1.78505820
157Abnormal respiratory motile cilium morphology (HP:0005938)1.78505820
158Duodenal stenosis (HP:0100867)1.77787618
159Small intestinal stenosis (HP:0012848)1.77787618
160Cerebral palsy (HP:0100021)1.77503643
161Constricted visual fields (HP:0001133)1.77319078
162Erectile abnormalities (HP:0100639)1.77066697
163Urticaria (HP:0001025)1.76585285
164Focal motor seizures (HP:0011153)1.76513966
165Sclerocornea (HP:0000647)1.75978676
166Keratoconjunctivitis sicca (HP:0001097)1.75549630
167Pachygyria (HP:0001302)1.75484229
168Recurrent lower respiratory tract infections (HP:0002783)1.75220274
169Abnormal urine output (HP:0012590)1.74843428
170Abnormality of macrophages (HP:0004311)1.74740821
171Abnormality of the renal collecting system (HP:0004742)1.74700815
172Glomerulopathy (HP:0100820)1.74531229
173Aplasia/Hypoplasia of the lens (HP:0008063)1.74211948
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.74174655
175Hypoplasia of the iris (HP:0007676)1.73794067
176Renal Fanconi syndrome (HP:0001994)1.73674745
177Abnormality of the lacrimal duct (HP:0011481)1.73011719
178Abnormality of placental membranes (HP:0011409)1.71374573
179Amniotic constriction ring (HP:0009775)1.71374573
180Status epilepticus (HP:0002133)1.71254877
181Large for gestational age (HP:0001520)1.70987221
182Tubulointerstitial nephritis (HP:0001970)1.70339752
183Hemiparesis (HP:0001269)1.68752041
184Gaze-evoked nystagmus (HP:0000640)1.68731680
185Increased serum lactate (HP:0002151)1.67747651
186Tubulointerstitial abnormality (HP:0001969)1.66839134
187Thyroid-stimulating hormone excess (HP:0002925)1.66168038
188Increased intramyocellular lipid droplets (HP:0012240)1.65223446
189Hyperglycinuria (HP:0003108)1.64855836
190Metabolic alkalosis (HP:0200114)1.64838041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.57758374
2VRK23.77586028
3TXK3.53077257
4MAP4K23.51686398
5CCNB12.99743186
6STK162.80310527
7PRPF4B2.77209448
8MAP2K72.72585109
9ZAK2.69655979
10TAOK32.67136473
11INSRR2.62125735
12EIF2AK22.54142800
13BLK2.50468204
14TIE12.49608444
15MAPK132.49075547
16CASK2.44563531
17TEC2.43450473
18PKN12.42170891
19MAP3K142.34487166
20WNK32.31679746
21IRAK42.28660862
22TAOK22.22616838
23PTK2B2.17573545
24IRAK32.12600663
25RIPK42.12239567
26BMX2.12071174
27WEE12.02592538
28TNK21.96617959
29WNK41.90690269
30BMPR1B1.79800798
31CAMK1G1.79442840
32TRPM71.77496238
33ERBB31.75743379
34CAMKK21.74051431
35NEK21.71093791
36CAMK11.70980297
37GRK11.58908915
38YES11.50990301
39TRIM281.49232545
40HIPK21.46032771
41ADRBK21.44623740
42MAP3K41.43952207
43TAF11.42802353
44CAMK1D1.40570605
45TNIK1.38348234
46BMPR21.37896688
47IKBKB1.26944207
48PAK31.26739524
49RIPK11.25423110
50OXSR11.24174458
51PIK3CA1.21989699
52STK391.21936899
53CSNK1G31.21277995
54MAPK151.20213439
55GRK51.17934899
56CLK11.17224545
57NEK61.13687996
58DYRK21.13507069
59CSNK1G11.13176975
60BCKDK1.13023141
61MST41.12837239
62EPHA41.06374980
63EIF2AK31.02354643
64CSNK1G21.02101940
65MAP2K61.01108404
66CSNK1A1L0.97429169
67ADRBK10.94102770
68BRD40.92312456
69AKT20.90749950
70ACVR1B0.89689046
71PIK3CG0.89144453
72GRK70.88718565
73MARK10.87313321
74SGK20.86078432
75SRPK10.85999574
76MAPKAPK50.82772042
77PINK10.81589658
78MUSK0.80785980
79MAP3K10.78694020
80EPHA20.77397894
81PRKCI0.77323454
82MAPKAPK30.76726598
83KDR0.75063574
84PRKCE0.73867896
85BRSK10.72826829
86PLK10.71592143
87MAP4K10.69718596
88PRKCG0.69167363
89DAPK20.68158304
90LYN0.68155466
91CDK30.66758830
92BTK0.66226447
93RPS6KB10.66043555
94AKT30.65645689
95VRK10.64913637
96DYRK30.64515733
97IKBKE0.63320726
98JAK30.61903578
99PHKG20.61760219
100PHKG10.61760219
101AURKA0.61103357
102STK38L0.59507797
103FLT30.59221271
104JAK10.59219533
105BCR0.59081141
106PLK30.57236796
107OBSCN0.57220485
108KIT0.57188101
109MKNK10.56930548
110LATS10.55896909
111HCK0.54882422
112BRSK20.54718983
113AURKB0.54307560
114NTRK20.53278216
115CHUK0.51548721
116PRKAA20.51441623
117PLK20.49756071
118ERBB40.48882749
119MAPK70.46681491
120PRKG10.46223876
121FES0.45952631
122PNCK0.44399271
123DAPK10.43918650
124PRKCD0.43805717
125CAMK2D0.43014549
126NUAK10.41775206
127NME10.41708739
128PRKG20.40245284
129PRKCQ0.40011127
130CAMK40.39560245
131CAMK2A0.39460277
132STK30.38255429
133MKNK20.37337686
134MAP3K120.37183212
135PRKACA0.36992824
136CSNK1D0.36913437
137SYK0.36798863
138SGK4940.35206793
139SGK2230.35206793
140MAPK120.35147069
141MAP3K70.34537178
142MATK0.34189622
143STK240.33797281
144PRKCA0.31972062
145MAPK30.29763047
146RPS6KA50.29462777
147TLK10.29440987
148ITK0.29310196
149PBK0.29127094
150FER0.28617795
151STK110.28045209
152ABL10.27645209
153CDC70.27406147
154CSNK1A10.27377476
155ATR0.27269647
156MAPK40.27105958
157FGR0.26987584
158GRK60.25033703
159NTRK30.24368674
160MAP2K40.24170676

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049774.31282236
2Linoleic acid metabolism_Homo sapiens_hsa005912.75796047
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.65955356
4Nitrogen metabolism_Homo sapiens_hsa009102.46644356
5Arachidonic acid metabolism_Homo sapiens_hsa005902.42287671
6Graft-versus-host disease_Homo sapiens_hsa053322.30141675
7Oxidative phosphorylation_Homo sapiens_hsa001902.24093021
8Histidine metabolism_Homo sapiens_hsa003402.21978893
9Rheumatoid arthritis_Homo sapiens_hsa053232.20620051
10Hematopoietic cell lineage_Homo sapiens_hsa046402.15168973
11Butanoate metabolism_Homo sapiens_hsa006502.15150956
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.12915498
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.93619681
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90844996
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.90562092
16Leishmaniasis_Homo sapiens_hsa051401.87598028
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86238515
18Propanoate metabolism_Homo sapiens_hsa006401.85658714
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85437936
20Protein export_Homo sapiens_hsa030601.80828916
21Caffeine metabolism_Homo sapiens_hsa002321.80747002
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.78951864
23Allograft rejection_Homo sapiens_hsa053301.78880233
24Ether lipid metabolism_Homo sapiens_hsa005651.75538477
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75359324
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74285687
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73108610
28Selenocompound metabolism_Homo sapiens_hsa004501.69548834
29Malaria_Homo sapiens_hsa051441.68893266
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67677180
31beta-Alanine metabolism_Homo sapiens_hsa004101.67442212
32Tryptophan metabolism_Homo sapiens_hsa003801.67026994
33Basal transcription factors_Homo sapiens_hsa030221.66966964
34Parkinsons disease_Homo sapiens_hsa050121.66114555
35Asthma_Homo sapiens_hsa053101.60956880
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60614671
37Autoimmune thyroid disease_Homo sapiens_hsa053201.55382130
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52562777
39RNA polymerase_Homo sapiens_hsa030201.39542210
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39010349
41ABC transporters_Homo sapiens_hsa020101.35480402
42Staphylococcus aureus infection_Homo sapiens_hsa051501.34979137
43TNF signaling pathway_Homo sapiens_hsa046681.33202568
44Phagosome_Homo sapiens_hsa041451.33193184
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.28338972
46Phenylalanine metabolism_Homo sapiens_hsa003601.28327529
47Peroxisome_Homo sapiens_hsa041461.26790571
48African trypanosomiasis_Homo sapiens_hsa051431.25377468
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22033749
50Fatty acid elongation_Homo sapiens_hsa000621.20881598
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19871743
52RNA degradation_Homo sapiens_hsa030181.18204658
53Measles_Homo sapiens_hsa051621.16546986
54Sphingolipid metabolism_Homo sapiens_hsa006001.16357827
55Osteoclast differentiation_Homo sapiens_hsa043801.15379921
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14072292
57Proteasome_Homo sapiens_hsa030501.13677442
58Fanconi anemia pathway_Homo sapiens_hsa034601.11222318
59Chemical carcinogenesis_Homo sapiens_hsa052041.09739058
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08790999
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06110094
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06017811
63Legionellosis_Homo sapiens_hsa051341.04713962
64Tuberculosis_Homo sapiens_hsa051521.02888174
65Sulfur metabolism_Homo sapiens_hsa009201.01063302
66Non-homologous end-joining_Homo sapiens_hsa034500.98884414
67Alzheimers disease_Homo sapiens_hsa050100.98553170
68Olfactory transduction_Homo sapiens_hsa047400.98387013
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98195066
70Phototransduction_Homo sapiens_hsa047440.97553045
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97446114
72Homologous recombination_Homo sapiens_hsa034400.96488721
73Other glycan degradation_Homo sapiens_hsa005110.95873369
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94956067
75One carbon pool by folate_Homo sapiens_hsa006700.94319170
76Regulation of autophagy_Homo sapiens_hsa041400.94140200
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93734546
78Huntingtons disease_Homo sapiens_hsa050160.93001709
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91555164
80Type I diabetes mellitus_Homo sapiens_hsa049400.91011719
81Pertussis_Homo sapiens_hsa051330.91010758
82Ovarian steroidogenesis_Homo sapiens_hsa049130.90031781
83Primary immunodeficiency_Homo sapiens_hsa053400.89628226
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89529127
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89210419
86Morphine addiction_Homo sapiens_hsa050320.88185627
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88044336
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85446183
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85374996
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.85358681
91ECM-receptor interaction_Homo sapiens_hsa045120.85257752
92Cardiac muscle contraction_Homo sapiens_hsa042600.82839866
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82053892
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81924506
95Metabolic pathways_Homo sapiens_hsa011000.80978876
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.80781292
97Collecting duct acid secretion_Homo sapiens_hsa049660.77314786
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74764894
99Nicotine addiction_Homo sapiens_hsa050330.72366663
100Glycerolipid metabolism_Homo sapiens_hsa005610.70962802
101Herpes simplex infection_Homo sapiens_hsa051680.70230622
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69998164
103Taste transduction_Homo sapiens_hsa047420.67456504
104Circadian entrainment_Homo sapiens_hsa047130.67308268
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67186648
106Glutathione metabolism_Homo sapiens_hsa004800.65396639
107Salmonella infection_Homo sapiens_hsa051320.63738594
108Chemokine signaling pathway_Homo sapiens_hsa040620.63402383
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.62954453
110Basal cell carcinoma_Homo sapiens_hsa052170.62907979
111Fatty acid degradation_Homo sapiens_hsa000710.62176165
112GABAergic synapse_Homo sapiens_hsa047270.61140510
113Insulin secretion_Homo sapiens_hsa049110.58825811
114Salivary secretion_Homo sapiens_hsa049700.57829580
115cAMP signaling pathway_Homo sapiens_hsa040240.57743700
116Small cell lung cancer_Homo sapiens_hsa052220.57442000
117Base excision repair_Homo sapiens_hsa034100.57133863
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56880179
119Steroid biosynthesis_Homo sapiens_hsa001000.56796258
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56133429
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56118060
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54367448
123Amoebiasis_Homo sapiens_hsa051460.53446452
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.53428421
125Hepatitis C_Homo sapiens_hsa051600.52886708
126Vitamin B6 metabolism_Homo sapiens_hsa007500.52708436
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.51336032
128RNA transport_Homo sapiens_hsa030130.50879107
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50877327
130Influenza A_Homo sapiens_hsa051640.50196526
131Pyruvate metabolism_Homo sapiens_hsa006200.49292842
132Rap1 signaling pathway_Homo sapiens_hsa040150.49200972
133Retinol metabolism_Homo sapiens_hsa008300.49189740
134Folate biosynthesis_Homo sapiens_hsa007900.49055440
135Toxoplasmosis_Homo sapiens_hsa051450.47787504
136Calcium signaling pathway_Homo sapiens_hsa040200.47082007
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46297545
138Nucleotide excision repair_Homo sapiens_hsa034200.45854122
139Arginine and proline metabolism_Homo sapiens_hsa003300.44542505
140Tyrosine metabolism_Homo sapiens_hsa003500.43842492
141Protein digestion and absorption_Homo sapiens_hsa049740.43378381
142Glutamatergic synapse_Homo sapiens_hsa047240.40033288
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.39776764
144Complement and coagulation cascades_Homo sapiens_hsa046100.38744360
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37172772
146Purine metabolism_Homo sapiens_hsa002300.36954353
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36848065
148Dorso-ventral axis formation_Homo sapiens_hsa043200.35676276
149Sulfur relay system_Homo sapiens_hsa041220.35660620
150Starch and sucrose metabolism_Homo sapiens_hsa005000.35471737
151Apoptosis_Homo sapiens_hsa042100.35071929
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34475741
153Serotonergic synapse_Homo sapiens_hsa047260.34333593
154B cell receptor signaling pathway_Homo sapiens_hsa046620.32659959
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.32388324
156Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29248219
157Pyrimidine metabolism_Homo sapiens_hsa002400.27605765
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27220730

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