GJE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.88039650
2axon ensheathment in central nervous system (GO:0032291)7.88039650
3fatty acid elongation (GO:0030497)6.09308028
4long-chain fatty acid biosynthetic process (GO:0042759)5.94743249
5myelination (GO:0042552)4.92755356
6ensheathment of neurons (GO:0007272)4.85248816
7axon ensheathment (GO:0008366)4.85248816
8negative regulation of neurotransmitter transport (GO:0051589)4.72135756
9glycerophospholipid catabolic process (GO:0046475)4.63365886
10negative regulation of protein localization to cell surface (GO:2000009)4.55748601
11presynaptic membrane assembly (GO:0097105)4.49110139
12presynaptic membrane organization (GO:0097090)4.40092036
13dopamine biosynthetic process (GO:0042416)4.25157919
14cholesterol biosynthetic process (GO:0006695)4.16083698
15neuron cell-cell adhesion (GO:0007158)4.14790573
16negative regulation of neurotransmitter secretion (GO:0046929)4.14560505
17limb bud formation (GO:0060174)4.04376412
18cerebral cortex radially oriented cell migration (GO:0021799)3.91317090
19isoprenoid biosynthetic process (GO:0008299)3.82283002
20eye photoreceptor cell differentiation (GO:0001754)3.78086660
21photoreceptor cell differentiation (GO:0046530)3.78086660
22sterol biosynthetic process (GO:0016126)3.75684672
23L-amino acid import (GO:0043092)3.66948897
24* lens development in camera-type eye (GO:0002088)3.56385387
25regulation of collateral sprouting (GO:0048670)3.52943939
26oligodendrocyte differentiation (GO:0048709)3.46787044
27transmission of nerve impulse (GO:0019226)3.37160576
28regulation of dopamine metabolic process (GO:0042053)3.35033989
29regulation of catecholamine metabolic process (GO:0042069)3.35033989
30response to redox state (GO:0051775)3.31463477
31preassembly of GPI anchor in ER membrane (GO:0016254)3.29398741
32neuron recognition (GO:0008038)3.25954751
33GPI anchor biosynthetic process (GO:0006506)3.24382114
34establishment of mitochondrion localization (GO:0051654)3.23101493
35import into cell (GO:0098657)3.17741891
36GPI anchor metabolic process (GO:0006505)3.12175647
37neuron remodeling (GO:0016322)3.09168072
38positive regulation of action potential (GO:0045760)3.08722424
39cellular response to epinephrine stimulus (GO:0071872)3.06582376
40dendritic spine morphogenesis (GO:0060997)2.97445126
41substantia nigra development (GO:0021762)2.94246950
42ionotropic glutamate receptor signaling pathway (GO:0035235)2.94062469
43histone H2B ubiquitination (GO:0033523)2.94018203
44lateral sprouting from an epithelium (GO:0060601)2.92445989
45microtubule polymerization or depolymerization (GO:0031109)2.91839048
46response to epinephrine (GO:0071871)2.90966485
47negative regulation of execution phase of apoptosis (GO:1900118)2.90877528
48amino acid import (GO:0043090)2.83068130
49catecholamine biosynthetic process (GO:0042423)2.79903932
50catechol-containing compound biosynthetic process (GO:0009713)2.79903932
51axonal fasciculation (GO:0007413)2.79558521
52astrocyte development (GO:0014002)2.78242366
53nucleotide transmembrane transport (GO:1901679)2.76005082
54negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.75473146
55gamma-aminobutyric acid signaling pathway (GO:0007214)2.72907279
56cranial nerve morphogenesis (GO:0021602)2.72677645
57retina layer formation (GO:0010842)2.72127814
58adult walking behavior (GO:0007628)2.71586501
59positive regulation of oligodendrocyte differentiation (GO:0048714)2.70738829
60glutamate receptor signaling pathway (GO:0007215)2.70589314
61cranial nerve development (GO:0021545)2.69163439
62regulation of feeding behavior (GO:0060259)2.68897358
63magnesium ion transport (GO:0015693)2.67062275
64positive regulation of synapse assembly (GO:0051965)2.67052137
65response to methylmercury (GO:0051597)2.64001554
66neuronal action potential propagation (GO:0019227)2.63693245
67negative regulation of axonogenesis (GO:0050771)2.61025845
68protein neddylation (GO:0045116)2.59219521
69negative regulation of axon extension (GO:0030517)2.58671893
70regulation of somitogenesis (GO:0014807)2.57635145
71protein palmitoylation (GO:0018345)2.57001066
72keratinocyte development (GO:0003334)2.55752087
73positive regulation of cellular amine metabolic process (GO:0033240)2.54500083
74apical protein localization (GO:0045176)2.52451611
75dopamine transport (GO:0015872)2.52381897
76polyol transport (GO:0015791)2.52211091
77developmental pigmentation (GO:0048066)2.51288644
78glycolipid biosynthetic process (GO:0009247)2.50638351
79startle response (GO:0001964)2.50588148
80asymmetric protein localization (GO:0008105)2.49612667
81long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.48584476
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48331508
83myelination in peripheral nervous system (GO:0022011)2.47853408
84peripheral nervous system axon ensheathment (GO:0032292)2.47853408
85dendrite development (GO:0016358)2.46325196
86regulation of pigment cell differentiation (GO:0050932)2.45121770
87long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.45057621
88negative regulation of exocytosis (GO:0045920)2.44520014
89spinal cord motor neuron differentiation (GO:0021522)2.44307019
90neuronal ion channel clustering (GO:0045161)2.42789083
91righting reflex (GO:0060013)2.40312748
92nonmotile primary cilium assembly (GO:0035058)2.40125415
93negative regulation of myoblast differentiation (GO:0045662)2.37794614
94forebrain neuron differentiation (GO:0021879)2.37616530
95peripheral nervous system development (GO:0007422)2.36844500
96membrane assembly (GO:0071709)2.35410975
97head development (GO:0060322)2.34823274
98neural nucleus development (GO:0048857)2.34229052
99neuron-neuron synaptic transmission (GO:0007270)2.33669971
100positive regulation of meiosis (GO:0045836)2.32234549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43528939
2GBX2_23144817_ChIP-Seq_PC3_Human3.81335700
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57310077
4TAF15_26573619_Chip-Seq_HEK293_Human2.54057941
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47537430
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.40912125
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39890205
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35045893
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.26621940
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26443778
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23925709
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.22400259
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14126531
14VDR_22108803_ChIP-Seq_LS180_Human2.08111073
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07678380
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06766409
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03717153
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01029137
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01029137
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99481248
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97005521
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96327753
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93410901
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84943675
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84360020
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.83586148
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82888796
28FUS_26573619_Chip-Seq_HEK293_Human1.79767902
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78593682
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78518756
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.77940309
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74309522
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72725640
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72462159
35ER_23166858_ChIP-Seq_MCF-7_Human1.69968056
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68054715
37P300_19829295_ChIP-Seq_ESCs_Human1.67938208
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67910142
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67714143
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67599878
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66021367
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.65482145
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61547441
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.58878297
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.53665013
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.52401709
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51316530
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50213121
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49903325
50AR_21572438_ChIP-Seq_LNCaP_Human1.47513510
51RNF2_27304074_Chip-Seq_NSC_Mouse1.44132000
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.42115285
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40753449
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39003737
55SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38762297
56SMAD4_21799915_ChIP-Seq_A2780_Human1.38416047
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36505313
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36045356
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.35806140
60P53_22387025_ChIP-Seq_ESCs_Mouse1.35432652
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.34476574
62DROSHA_22980978_ChIP-Seq_HELA_Human1.34122098
63P300_18555785_Chip-Seq_ESCs_Mouse1.33293895
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33238746
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.32330452
66IGF1R_20145208_ChIP-Seq_DFB_Human1.31420422
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31318125
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.27947638
69STAT3_18555785_Chip-Seq_ESCs_Mouse1.27735524
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25734978
71STAT3_23295773_ChIP-Seq_U87_Human1.25280829
72RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25025229
73TP53_18474530_ChIP-ChIP_U2OS_Human1.24978999
74REST_21632747_ChIP-Seq_MESCs_Mouse1.24883395
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23930505
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23586570
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22157878
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.21178221
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.18431047
80RUNX2_22187159_ChIP-Seq_PCA_Human1.17443995
81TCF4_23295773_ChIP-Seq_U87_Human1.16884277
82EWS_26573619_Chip-Seq_HEK293_Human1.16791354
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16790707
84KLF4_18555785_Chip-Seq_ESCs_Mouse1.16629913
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16614221
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16145888
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16145888
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14866950
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.14606603
90NMYC_18555785_Chip-Seq_ESCs_Mouse1.14548462
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12832506
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.08542693
93SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08228713
94ZFX_18555785_Chip-Seq_ESCs_Mouse1.07192972
95TP53_16413492_ChIP-PET_HCT116_Human1.06355143
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06082843
97PU1_27457419_Chip-Seq_LIVER_Mouse1.05728504
98IRF1_19129219_ChIP-ChIP_H3396_Human1.05351953
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02490691
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.02310458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.35517409
2MP0000920_abnormal_myelination3.35002682
3MP0004742_abnormal_vestibular_system2.89124312
4MP0005409_darkened_coat_color2.81711084
5MP0004270_analgesia2.77709883
6MP0001486_abnormal_startle_reflex2.70784476
7MP0001905_abnormal_dopamine_level2.69869071
8MP0005423_abnormal_somatic_nervous2.58513764
9MP0003136_yellow_coat_color2.52876321
10MP0005171_absent_coat_pigmentation2.41150891
11MP0001529_abnormal_vocalization2.39387039
12MP0000778_abnormal_nervous_system2.36510531
13MP0000566_synostosis2.36445429
14MP0001188_hyperpigmentation2.32214521
15MP0002272_abnormal_nervous_system2.29098475
16MP0002102_abnormal_ear_morphology2.25610868
17MP0001485_abnormal_pinna_reflex2.11757652
18MP0004142_abnormal_muscle_tone1.97392692
19MP0002064_seizures1.92933911
20MP0009745_abnormal_behavioral_response1.92166714
21MP0003635_abnormal_synaptic_transmissio1.83089415
22MP0004859_abnormal_synaptic_plasticity1.80823397
23MP0006292_abnormal_olfactory_placode1.79426279
24MP0003950_abnormal_plasma_membrane1.75351607
25MP0002734_abnormal_mechanical_nocicepti1.73575597
26MP0003787_abnormal_imprinting1.72085788
27MP0003938_abnormal_ear_development1.69401861
28MP0009046_muscle_twitch1.67364824
29MP0002572_abnormal_emotion/affect_behav1.65839392
30MP0005551_abnormal_eye_electrophysiolog1.65502849
31MP0005451_abnormal_body_composition1.53770315
32MP0001963_abnormal_hearing_physiology1.51572703
33MP0000026_abnormal_inner_ear1.50950695
34MP0001440_abnormal_grooming_behavior1.50071510
35MP0006276_abnormal_autonomic_nervous1.49524888
36MP0002067_abnormal_sensory_capabilities1.48660676
37MP0002735_abnormal_chemical_nociception1.48007727
38MP0002063_abnormal_learning/memory/cond1.47817308
39MP0000462_abnormal_digestive_system1.47783370
40MP0004381_abnormal_hair_follicle1.46356213
41MP0004885_abnormal_endolymph1.45204139
42MP0003690_abnormal_glial_cell1.44859358
43MP0000383_abnormal_hair_follicle1.38098303
44MP0003632_abnormal_nervous_system1.32895371
45MP0001968_abnormal_touch/_nociception1.31117502
46MP0001986_abnormal_taste_sensitivity1.30712898
47MP0005253_abnormal_eye_physiology1.29251238
48MP0002882_abnormal_neuron_morphology1.28844665
49MP0001346_abnormal_lacrimal_gland1.28777479
50MP0002229_neurodegeneration1.27602088
51MP0000955_abnormal_spinal_cord1.27506521
52MP0002752_abnormal_somatic_nervous1.27184060
53MP0006072_abnormal_retinal_apoptosis1.25936722
54MP0005379_endocrine/exocrine_gland_phen1.24973757
55MP0009250_abnormal_appendicular_skeleto1.23289325
56MP0005645_abnormal_hypothalamus_physiol1.22348597
57MP0003937_abnormal_limbs/digits/tail_de1.21851642
58MP0003634_abnormal_glial_cell1.21491697
59MP0004134_abnormal_chest_morphology1.20064547
60MP0002184_abnormal_innervation1.18314968
61MP0002736_abnormal_nociception_after1.17488183
62MP0003122_maternal_imprinting1.16274578
63MP0001970_abnormal_pain_threshold1.15358974
64MP0002557_abnormal_social/conspecific_i1.11417600
65MP0002066_abnormal_motor_capabilities/c1.11343208
66MP0002938_white_spotting1.10487743
67MP0003329_amyloid_beta_deposits1.10267084
68MP0000631_abnormal_neuroendocrine_gland1.09643280
69MP0005386_behavior/neurological_phenoty1.09218815
70MP0004924_abnormal_behavior1.09218815
71MP0002733_abnormal_thermal_nociception1.04912604
72MP0005410_abnormal_fertilization1.04261707
73MP0010678_abnormal_skin_adnexa1.03878481
74MP0000762_abnormal_tongue_morphology1.02545470
75* MP0002697_abnormal_eye_size1.00801254
76MP0003385_abnormal_body_wall1.00491390
77MP0002233_abnormal_nose_morphology0.99220580
78MP0000049_abnormal_middle_ear0.98319375
79* MP0005195_abnormal_posterior_eye0.97455749
80MP0001501_abnormal_sleep_pattern0.95793398
81MP0002163_abnormal_gland_morphology0.94193990
82MP0003631_nervous_system_phenotype0.93316793
83MP0000647_abnormal_sebaceous_gland0.89146138
84MP0002152_abnormal_brain_morphology0.86963424
85MP0002249_abnormal_larynx_morphology0.86917029
86MP0001299_abnormal_eye_distance/0.84773399
87MP0005646_abnormal_pituitary_gland0.83208874
88MP0003121_genomic_imprinting0.82520606
89MP0002638_abnormal_pupillary_reflex0.82105535
90MP0001664_abnormal_digestion0.81600117
91MP0002277_abnormal_respiratory_mucosa0.75587248
92MP0000372_irregular_coat_pigmentation0.75281181
93MP0001177_atelectasis0.75233459
94MP0004145_abnormal_muscle_electrophysio0.75132437
95MP0009379_abnormal_foot_pigmentation0.74363422
96MP0008569_lethality_at_weaning0.74131171
97MP0003137_abnormal_impulse_conducting0.74100912
98MP0001502_abnormal_circadian_rhythm0.73734297
99MP0004133_heterotaxia0.73147063
100MP0002751_abnormal_autonomic_nervous0.70818372

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.53823055
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.53823055
3Nuclear cataract (HP:0100018)5.12489730
4Parakeratosis (HP:0001036)5.03323438
5Zonular cataract (HP:0010920)4.58829241
6Neurofibrillary tangles (HP:0002185)4.00490794
7Abnormality of the corticospinal tract (HP:0002492)3.89161503
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.54314012
9Anomalous pulmonary venous return (HP:0010772)3.09380836
10Sensory axonal neuropathy (HP:0003390)2.99961543
11Cerebral inclusion bodies (HP:0100314)2.88446030
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.84839420
13Absent/shortened dynein arms (HP:0200106)2.84839420
14Retinal dysplasia (HP:0007973)2.84145837
15Patchy hypopigmentation of hair (HP:0011365)2.75945988
16White forelock (HP:0002211)2.73045287
17Corneal dystrophy (HP:0001131)2.70762259
18Abnormality of the pulmonary veins (HP:0011718)2.69591478
19Duplicated collecting system (HP:0000081)2.65678811
20Focal motor seizures (HP:0011153)2.65537771
21Thickened helices (HP:0000391)2.60348477
22Absent septum pellucidum (HP:0001331)2.52382524
23Cupped ear (HP:0000378)2.52327011
24Congenital sensorineural hearing impairment (HP:0008527)2.49338079
25Adrenal hypoplasia (HP:0000835)2.49022081
26Spastic gait (HP:0002064)2.47949791
27Partial duplication of thumb phalanx (HP:0009944)2.47217556
28Abnormality of the renal collecting system (HP:0004742)2.46703085
29Limb dystonia (HP:0002451)2.45366229
30Aplasia of the musculature (HP:0100854)2.42944582
31Termporal pattern (HP:0011008)2.37756529
32Insidious onset (HP:0003587)2.37756529
33Supranuclear gaze palsy (HP:0000605)2.35744380
34Alacrima (HP:0000522)2.32097119
35Clumsiness (HP:0002312)2.31585615
36Congenital ichthyosiform erythroderma (HP:0007431)2.31470815
37Duplication of thumb phalanx (HP:0009942)2.30620824
38Renal Fanconi syndrome (HP:0001994)2.29765830
39Bell-shaped thorax (HP:0001591)2.29254372
40Akinesia (HP:0002304)2.28129652
41Septo-optic dysplasia (HP:0100842)2.27691661
42Peripheral hypomyelination (HP:0007182)2.27481715
43Increased serum pyruvate (HP:0003542)2.26528497
44Abnormality of glycolysis (HP:0004366)2.26528497
45Abnormality of the septum pellucidum (HP:0007375)2.23619619
46Overfolded helix (HP:0000396)2.17912458
47Amblyopia (HP:0000646)2.14977372
48Abnormal ciliary motility (HP:0012262)2.14033920
49Abnormality of incisor morphology (HP:0011063)2.14002399
50Partial duplication of the phalanx of hand (HP:0009999)2.10834685
51Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10669372
52Split foot (HP:0001839)2.10636371
53Aplasia cutis congenita (HP:0001057)2.09824381
54Atelectasis (HP:0100750)2.07758769
55Abnormal respiratory epithelium morphology (HP:0012253)2.07338924
56Abnormal respiratory motile cilium morphology (HP:0005938)2.07338924
57Epileptic encephalopathy (HP:0200134)2.05863546
58Gastroesophageal reflux (HP:0002020)2.05452811
59Dysmetria (HP:0001310)2.04172967
60Onion bulb formation (HP:0003383)2.04166470
61Myelomeningocele (HP:0002475)2.04083636
62Hypophosphatemic rickets (HP:0004912)2.01288538
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98096337
64Mixed hearing impairment (HP:0000410)1.96283236
65Metabolic alkalosis (HP:0200114)1.94370820
66Decreased lacrimation (HP:0000633)1.93010748
67Prolonged neonatal jaundice (HP:0006579)1.92440994
68Conical tooth (HP:0000698)1.91416701
69Autoamputation (HP:0001218)1.90102477
70Morphological abnormality of the inner ear (HP:0011390)1.89688647
71Synostosis involving the elbow (HP:0003938)1.89255242
72Humeroradial synostosis (HP:0003041)1.89255242
73Hyperventilation (HP:0002883)1.88822169
74Steppage gait (HP:0003376)1.88357900
75Scanning speech (HP:0002168)1.87273447
76Partial agenesis of the corpus callosum (HP:0001338)1.85586708
77Acute necrotizing encephalopathy (HP:0006965)1.83525337
78Chin dimple (HP:0010751)1.82329454
79Abnormally folded helix (HP:0008544)1.82115694
80Optic disc pallor (HP:0000543)1.81792999
81Leukodystrophy (HP:0002415)1.81396457
82Aplasia/Hypoplasia of the lens (HP:0008063)1.80593840
83Nasolacrimal duct obstruction (HP:0000579)1.77658895
84Methylmalonic acidemia (HP:0002912)1.77356578
85Broad-based gait (HP:0002136)1.76293243
86Progressive cerebellar ataxia (HP:0002073)1.75752161
87Hypoplasia of the iris (HP:0007676)1.75165008
88Abnormality of renal resorption (HP:0011038)1.74558663
89Vaginal atresia (HP:0000148)1.72711567
90Genital tract atresia (HP:0001827)1.72228007
91Increased hepatocellular lipid droplets (HP:0006565)1.70855374
92Hypoplastic left heart (HP:0004383)1.70745119
93Meningocele (HP:0002435)1.70708941
94Hypomagnesemia (HP:0002917)1.68637896
95Congenital primary aphakia (HP:0007707)1.68504947
96Tubulointerstitial nephritis (HP:0001970)1.68182129
97Increased circulating renin level (HP:0000848)1.67996145
98Hypoplastic heart (HP:0001961)1.66098731
99Slow saccadic eye movements (HP:0000514)1.65479565
100Medial flaring of the eyebrow (HP:0010747)1.64677563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.54328990
2OXSR13.41527950
3CASK3.34521966
4TNIK3.24433398
5PNCK2.56085325
6EPHB12.31551180
7WNK42.28308832
8PKN12.19558422
9BMPR1B2.15021510
10BCR2.07907389
11STK162.04800288
12BLK2.01284070
13PBK1.77260144
14EPHA41.72874308
15MAPKAPK51.72470942
16MARK11.69996797
17WNK11.63857768
18CDK191.63426491
19FGR1.58350152
20NEK61.56901196
21MAPK131.51795051
22UHMK11.50112781
23CSNK1G31.41710984
24CSNK1A1L1.38112411
25MAP2K71.35843156
26CLK11.35123742
27CAMK2B1.32772068
28NTRK31.28984861
29DYRK21.24304487
30FGFR21.20044261
31CSNK1G11.14542762
32IRAK21.13670856
33PRPF4B1.10398664
34BMPR21.08198260
35ROCK21.06100333
36CSNK1G21.02618271
37MKNK21.02520177
38ADRBK21.01410604
39MUSK1.01253174
40PLK21.00943916
41CAMK2A1.00027281
42MKNK10.99901066
43GRK70.99343205
44INSRR0.97976261
45CAMK2D0.96660641
46GRK10.95779927
47PRKCE0.88674015
48PRKCQ0.85072372
49SGK2230.84420563
50SGK4940.84420563
51PAK60.83097222
52FES0.80853475
53MST40.80742117
54EIF2AK20.80291927
55MARK20.79562390
56MAP3K40.79169807
57DYRK1A0.77918747
58NTRK20.77806316
59PAK30.77617704
60NTRK10.72259236
61MET0.71997624
62PIK3CA0.71828292
63YES10.70655796
64CDK50.70256931
65CAMK1G0.69097599
66PRKG10.66870984
67CDK30.66005487
68IRAK10.65233524
69IRAK40.64207074
70ICK0.64012364
71CAMK2G0.63262648
72NME10.63067223
73BRD40.61238215
74NUAK10.60851521
75WNK30.58451328
76SGK10.57356647
77RPS6KA50.56347883
78GRK50.53512519
79DDR20.53237514
80CDK140.52584044
81CDK150.49349438
82CDK180.48052282
83ADRBK10.47650631
84FYN0.45575596
85CDK11A0.45304005
86PRKACA0.44371894
87MAPK150.41804193
88CSNK1A10.41151269
89TLK10.40490343
90CSNK1D0.39797748
91PRKACB0.39686491
92ZAK0.39510421
93PHKG10.39115334
94PHKG20.39115334
95MAP3K140.38315629
96OBSCN0.37331957
97ERBB40.36417221
98TXK0.35927297
99DMPK0.35054779
100TNK20.33742181

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.81625507
2Steroid biosynthesis_Homo sapiens_hsa001003.84407256
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.51807193
4Fatty acid elongation_Homo sapiens_hsa000623.44249744
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78865115
6Ether lipid metabolism_Homo sapiens_hsa005652.76381695
7Nicotine addiction_Homo sapiens_hsa050332.50598698
8Oxidative phosphorylation_Homo sapiens_hsa001902.17673669
9Serotonergic synapse_Homo sapiens_hsa047262.02555443
10Axon guidance_Homo sapiens_hsa043601.91496580
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83975235
12Sphingolipid metabolism_Homo sapiens_hsa006001.80709409
13Protein export_Homo sapiens_hsa030601.78800020
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73999850
15Glutamatergic synapse_Homo sapiens_hsa047241.72598529
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71018481
17Alzheimers disease_Homo sapiens_hsa050101.59060894
18Linoleic acid metabolism_Homo sapiens_hsa005911.58030215
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56043559
20Parkinsons disease_Homo sapiens_hsa050121.52982694
21Taste transduction_Homo sapiens_hsa047421.51958826
22Phototransduction_Homo sapiens_hsa047441.49928859
23Morphine addiction_Homo sapiens_hsa050321.48425684
24GABAergic synapse_Homo sapiens_hsa047271.40320798
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35851573
26Long-term depression_Homo sapiens_hsa047301.34073127
27Autoimmune thyroid disease_Homo sapiens_hsa053201.34033797
28Cocaine addiction_Homo sapiens_hsa050301.28695286
29Butanoate metabolism_Homo sapiens_hsa006501.16307672
30Histidine metabolism_Homo sapiens_hsa003401.16161024
31Sulfur metabolism_Homo sapiens_hsa009201.16019606
32Collecting duct acid secretion_Homo sapiens_hsa049661.14842314
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12143537
34Arachidonic acid metabolism_Homo sapiens_hsa005901.07409156
35Circadian entrainment_Homo sapiens_hsa047131.05389338
36Dopaminergic synapse_Homo sapiens_hsa047281.05361770
37Amphetamine addiction_Homo sapiens_hsa050311.00284942
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90408632
39Huntingtons disease_Homo sapiens_hsa050160.87765917
40Salivary secretion_Homo sapiens_hsa049700.87124879
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87051458
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86606385
43Cardiac muscle contraction_Homo sapiens_hsa042600.84845602
44Rheumatoid arthritis_Homo sapiens_hsa053230.84712568
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82995356
46Cholinergic synapse_Homo sapiens_hsa047250.82453148
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.79555395
48Non-homologous end-joining_Homo sapiens_hsa034500.79215516
49Calcium signaling pathway_Homo sapiens_hsa040200.78649977
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77090184
51Ras signaling pathway_Homo sapiens_hsa040140.74274884
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.74089328
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73147679
54Ovarian steroidogenesis_Homo sapiens_hsa049130.73142523
55Vibrio cholerae infection_Homo sapiens_hsa051100.65853073
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.64504275
57Renin secretion_Homo sapiens_hsa049240.64340886
58Arginine and proline metabolism_Homo sapiens_hsa003300.63526567
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56014411
60Hedgehog signaling pathway_Homo sapiens_hsa043400.53259297
61cAMP signaling pathway_Homo sapiens_hsa040240.52304910
62Renal cell carcinoma_Homo sapiens_hsa052110.51883423
63Wnt signaling pathway_Homo sapiens_hsa043100.51881835
64Tight junction_Homo sapiens_hsa045300.51390345
65Long-term potentiation_Homo sapiens_hsa047200.50968736
66Gastric acid secretion_Homo sapiens_hsa049710.50432106
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49379660
68Pancreatic secretion_Homo sapiens_hsa049720.48861045
69Phagosome_Homo sapiens_hsa041450.45485612
70Insulin secretion_Homo sapiens_hsa049110.45022053
71Vitamin B6 metabolism_Homo sapiens_hsa007500.44842828
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.44817503
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44782993
74Oxytocin signaling pathway_Homo sapiens_hsa049210.44663741
75ErbB signaling pathway_Homo sapiens_hsa040120.44067819
76ECM-receptor interaction_Homo sapiens_hsa045120.43326161
77Synaptic vesicle cycle_Homo sapiens_hsa047210.42867500
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41903209
79Fanconi anemia pathway_Homo sapiens_hsa034600.41051428
80Choline metabolism in cancer_Homo sapiens_hsa052310.40356255
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.40157621
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39619163
83Mineral absorption_Homo sapiens_hsa049780.38484767
84African trypanosomiasis_Homo sapiens_hsa051430.37669038
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37344283
86Basal cell carcinoma_Homo sapiens_hsa052170.35871538
87Olfactory transduction_Homo sapiens_hsa047400.35764723
88Melanogenesis_Homo sapiens_hsa049160.35521218
89Tyrosine metabolism_Homo sapiens_hsa003500.35290509
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35224596
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34835113
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34829670
93Alcoholism_Homo sapiens_hsa050340.33432492
94Graft-versus-host disease_Homo sapiens_hsa053320.33356304
95MAPK signaling pathway_Homo sapiens_hsa040100.32413310
96Metabolic pathways_Homo sapiens_hsa011000.32170835
97Dilated cardiomyopathy_Homo sapiens_hsa054140.31474378
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31136222
99Retinol metabolism_Homo sapiens_hsa008300.30067915
100Allograft rejection_Homo sapiens_hsa053300.29172343

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