GK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.97351060
2motile cilium assembly (GO:0044458)9.78240419
3reproduction (GO:0000003)9.63535922
4piRNA metabolic process (GO:0034587)9.52983333
5spermatid development (GO:0007286)9.14866784
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.56430417
7cilium movement (GO:0003341)8.46984722
8male meiosis (GO:0007140)8.42475139
9regulation of cilium movement (GO:0003352)7.86248029
10synaptonemal complex organization (GO:0070193)7.75991838
11single fertilization (GO:0007338)7.68082172
12synaptonemal complex assembly (GO:0007130)7.46016613
13sperm capacitation (GO:0048240)6.69773193
14fertilization (GO:0009566)6.49484620
15DNA methylation involved in gamete generation (GO:0043046)6.07449464
16spermatogenesis (GO:0007283)6.04332065
17male gamete generation (GO:0048232)6.02189998
18negative regulation of inclusion body assembly (GO:0090084)5.98580529
19microtubule depolymerization (GO:0007019)5.82066127
20gamete generation (GO:0007276)5.53907425
21male meiosis I (GO:0007141)5.50796833
22organic cation transport (GO:0015695)5.38394975
23ventricular system development (GO:0021591)5.36783654
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.30431552
25chromosome organization involved in meiosis (GO:0070192)5.28094344
26germ cell development (GO:0007281)5.24173047
27cell recognition (GO:0008037)4.99079215
28regulation of inclusion body assembly (GO:0090083)4.95861883
29calcium ion-dependent exocytosis (GO:0017156)4.94517946
30meiotic nuclear division (GO:0007126)4.89063144
31seminiferous tubule development (GO:0072520)4.82597466
32regulation of microtubule-based movement (GO:0060632)4.63859350
33meiosis I (GO:0007127)4.44296910
34microtubule severing (GO:0051013)4.41052080
35multicellular organismal reproductive process (GO:0048609)4.35535474
36protein localization to cilium (GO:0061512)4.24158305
37monoubiquitinated protein deubiquitination (GO:0035520)4.20680366
38meiotic cell cycle (GO:0051321)4.14694890
39left/right pattern formation (GO:0060972)4.14473460
40spermatid nucleus differentiation (GO:0007289)4.00028850
41glycerol ether metabolic process (GO:0006662)3.98222830
42chaperone-mediated protein complex assembly (GO:0051131)3.97122359
43genitalia morphogenesis (GO:0035112)3.83500598
44ether metabolic process (GO:0018904)3.67746244
45gene silencing by RNA (GO:0031047)3.63172260
46intraciliary transport (GO:0042073)3.57468778
47multicellular organismal development (GO:0007275)3.54331664
48protein polyglutamylation (GO:0018095)3.40276829
49lactate metabolic process (GO:0006089)3.36648891
50chromosome condensation (GO:0030261)3.31299673
51synapsis (GO:0007129)3.27124082
52axoneme assembly (GO:0035082)3.26063070
53amino-acid betaine transport (GO:0015838)3.25635908
54carnitine transport (GO:0015879)3.25635908
55microtubule-based movement (GO:0007018)3.24172747
56carnitine transmembrane transport (GO:1902603)3.19331220
57DNA packaging (GO:0006323)3.18599260
58protein K11-linked deubiquitination (GO:0035871)3.17550327
59negative regulation of organelle assembly (GO:1902116)3.13512107
60meiotic cell cycle process (GO:1903046)3.10383490
61regulation of spindle checkpoint (GO:0090231)3.08317648
62nucleoside diphosphate phosphorylation (GO:0006165)3.08045509
63cilium organization (GO:0044782)3.06694100
64regulation of centriole replication (GO:0046599)3.03357116
65cilium morphogenesis (GO:0060271)3.02124854
66microtubule polymerization or depolymerization (GO:0031109)3.01567567
67centriole assembly (GO:0098534)2.99509120
68GTP biosynthetic process (GO:0006183)2.95177002
69cilium assembly (GO:0042384)2.93552642
70cellular component assembly involved in morphogenesis (GO:0010927)2.91006260
71mitotic sister chromatid cohesion (GO:0007064)2.90115942
72protein refolding (GO:0042026)2.87911388
73nuclear pore complex assembly (GO:0051292)2.85968868
74centriole replication (GO:0007099)2.85621618
75glycolytic process (GO:0006096)2.80813250
76regulation of meiosis I (GO:0060631)2.78818372
77sequestering of actin monomers (GO:0042989)2.77356048
78regulation of protein polyubiquitination (GO:1902914)2.75814878
79nucleus organization (GO:0006997)2.65433041
80UTP biosynthetic process (GO:0006228)2.63458770
81gene silencing (GO:0016458)2.59678849
82single strand break repair (GO:0000012)2.56212855
83peptidyl-glutamic acid modification (GO:0018200)2.50561454
84single-organism membrane fusion (GO:0044801)2.47146785
85negative regulation of DNA repair (GO:0045738)2.46459323
86UTP metabolic process (GO:0046051)2.39718953
87regulation of cilium assembly (GO:1902017)2.37915265
88fusion of sperm to egg plasma membrane (GO:0007342)14.7505299
89cilium or flagellum-dependent cell motility (GO:0001539)13.7644834
90sperm motility (GO:0030317)12.4047857
91acrosome assembly (GO:0001675)12.0607887
92cell wall macromolecule metabolic process (GO:0044036)11.8487999
93cell wall macromolecule catabolic process (GO:0016998)11.8487999
94multicellular organism reproduction (GO:0032504)11.7470499
95sperm-egg recognition (GO:0035036)11.5197900
96plasma membrane fusion (GO:0045026)11.2430497
97axonemal dynein complex assembly (GO:0070286)10.7882811
98acrosome reaction (GO:0007340)10.5395648
99binding of sperm to zona pellucida (GO:0007339)10.4445439
100cell-cell recognition (GO:0009988)10.3064536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84902181
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.67663490
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.03167042
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66765844
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50124422
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.47992210
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47451270
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20006242
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.13944471
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09767334
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07788147
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1915853
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94455684
14VDR_22108803_ChIP-Seq_LS180_Human1.82652545
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81911552
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.76348961
17TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.75057554
18* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.67949505
19KAP1_22055183_ChIP-Seq_ESCs_Mouse1.65787838
20STAT1_17558387_ChIP-Seq_HELA_Human1.64802737
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64760018
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.64245679
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.61171498
24* ZNF274_21170338_ChIP-Seq_K562_Hela1.58347135
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.57811330
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54987965
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.48237253
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46281888
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46099347
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45453166
31* TAL1_26923725_Chip-Seq_HPCs_Mouse1.44154039
32* KDM2B_26808549_Chip-Seq_REH_Human1.41061139
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40270384
34GATA3_21867929_ChIP-Seq_CD8_Mouse1.37172653
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36588851
36CBP_20019798_ChIP-Seq_JUKART_Human1.36588851
37SOX2_22085726_ChIP-Seq_NPCs_Mouse1.36319112
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31514015
39FLI1_21867929_ChIP-Seq_TH2_Mouse1.28102781
40LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27541722
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27263150
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27239812
43CRX_20693478_ChIP-Seq_RETINA_Mouse1.22626023
44GATA3_21867929_ChIP-Seq_TH1_Mouse1.19614950
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17132315
46* REST_21632747_ChIP-Seq_MESCs_Mouse1.16447218
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.14649546
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14596138
49SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14270184
50SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14132379
51P53_21459846_ChIP-Seq_SAOS-2_Human1.14079913
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11915506
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11902282
54GF1_26923725_Chip-Seq_HPCs_Mouse1.10844991
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10212366
56OCT4_18555785_Chip-Seq_ESCs_Mouse1.10133334
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08627638
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.08310763
59FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07807458
60RNF2_27304074_Chip-Seq_NSC_Mouse1.07108618
61CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06823704
62P53_22387025_ChIP-Seq_ESCs_Mouse1.05250319
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05091219
64RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03739306
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02567399
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02567399
67RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02339620
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02216835
69* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01711777
70P300_18555785_Chip-Seq_ESCs_Mouse1.01255869
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00896650
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.00208628
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99367430
74CMYC_18555785_Chip-Seq_ESCs_Mouse0.98592408
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97678573
76* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97406762
77ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95324186
78TAF15_26573619_Chip-Seq_HEK293_Human0.94203247
79ESET_19884257_ChIP-Seq_ESCs_Mouse0.94030028
80SPI1_26923725_Chip-Seq_HPCs_Mouse0.91785745
81STAT3_18555785_Chip-Seq_ESCs_Mouse0.91296821
82ERG_20517297_ChIP-Seq_VCAP_Human0.91066651
83SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90984340
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90843295
85* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90143749
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89770205
87SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89667676
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89618646
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89553266
90GF1B_26923725_Chip-Seq_HPCs_Mouse0.88316903
91PU1_27457419_Chip-Seq_LIVER_Mouse0.87709291
92LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87369319
93SOX9_26525672_Chip-Seq_HEART_Mouse0.87035680
94FLI1_21867929_ChIP-Seq_CD8_Mouse0.86582881
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.85786039
96CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85367092
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84328126
98MYC_27129775_Chip-Seq_CORNEA_Mouse0.84175956
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.84036613
100NFYB_21822215_ChIP-Seq_K562_Human0.83700929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03793321
2MP0001929_abnormal_gametogenesis5.56864473
3MP0008877_abnormal_DNA_methylation5.14018197
4MP0002210_abnormal_sex_determination3.73103139
5MP0002161_abnormal_fertility/fecundity3.26365757
6MP0002653_abnormal_ependyma_morphology3.17857304
7MP0001145_abnormal_male_reproductive3.14243464
8MP0000653_abnormal_sex_gland2.73622143
9MP0005670_abnormal_white_adipose2.06024248
10MP0005410_abnormal_fertilization15.6796435
11MP0005623_abnormal_meninges_morphology1.96501937
12MP0002160_abnormal_reproductive_system1.84596396
13MP0008057_abnormal_DNA_replication1.61277845
14MP0002282_abnormal_trachea_morphology1.37743951
15MP0004233_abnormal_muscle_weight1.32401635
16MP0003646_muscle_fatigue1.27046388
17MP0008058_abnormal_DNA_repair1.20004823
18MP0005647_abnormal_sex_gland1.19296202
19MP0009046_muscle_twitch1.17531627
20MP0001984_abnormal_olfaction1.09522540
21MP0010094_abnormal_chromosome_stability1.05315090
22MP0001765_abnormal_ion_homeostasis1.02840482
23MP0003011_delayed_dark_adaptation1.00850383
24MP0008995_early_reproductive_senescence0.99480784
25MP0005389_reproductive_system_phenotype0.93694414
26MP0002234_abnormal_pharynx_morphology0.79081787
27MP0003786_premature_aging0.78520118
28MP0008007_abnormal_cellular_replicative0.73053358
29MP0000569_abnormal_digit_pigmentation0.62985596
30MP0000358_abnormal_cell_content/0.60009685
31MP0003115_abnormal_respiratory_system0.56239671
32MP0003950_abnormal_plasma_membrane0.55595638
33MP0002928_abnormal_bile_duct0.54741612
34MP0002102_abnormal_ear_morphology0.54727925
35MP0003878_abnormal_ear_physiology0.54453745
36MP0005377_hearing/vestibular/ear_phenot0.54453745
37MP0005636_abnormal_mineral_homeostasis0.52335780
38MP0005397_hematopoietic_system_phenotyp0.50876577
39MP0001545_abnormal_hematopoietic_system0.50876577
40MP0010307_abnormal_tumor_latency0.50511735
41MP0004134_abnormal_chest_morphology0.49252570
42MP0004808_abnormal_hematopoietic_stem0.48415264
43MP0003699_abnormal_female_reproductive0.47241178
44MP0003111_abnormal_nucleus_morphology0.46830020
45MP0005551_abnormal_eye_electrophysiolog0.46518283
46MP0001324_abnormal_eye_pigmentation0.45462045
47MP0005666_abnormal_adipose_tissue0.44299396
48MP0003329_amyloid_beta_deposits0.42602625
49MP0005253_abnormal_eye_physiology0.42171469
50MP0002269_muscular_atrophy0.40729092
51MP0004036_abnormal_muscle_relaxation0.40538368
52MP0009278_abnormal_bone_marrow0.39799345
53MP0001119_abnormal_female_reproductive0.39690569
54MP0004019_abnormal_vitamin_homeostasis0.38558646
55MP0001293_anophthalmia0.37766061
56MP0001730_embryonic_growth_arrest0.35467937
57MP0002971_abnormal_brown_adipose0.34899255
58MP0001764_abnormal_homeostasis0.32748196
59MP0005391_vision/eye_phenotype0.32425319
60MP0009115_abnormal_fat_cell0.29711135
61MP0006036_abnormal_mitochondrial_physio0.29346935
62MP0003633_abnormal_nervous_system0.28470303
63MP0002139_abnormal_hepatobiliary_system0.28125079
64MP0003861_abnormal_nervous_system0.25617461
65MP0001727_abnormal_embryo_implantation0.25087307
66MP0000313_abnormal_cell_death0.24344020
67MP0003077_abnormal_cell_cycle0.23831865
68MP0002152_abnormal_brain_morphology0.23827147
69MP0004811_abnormal_neuron_physiology0.23390867
70MP0000427_abnormal_hair_cycle0.23240492
71MP0008961_abnormal_basal_metabolism0.22205650
72MP0001661_extended_life_span0.21229104
73MP0003045_fibrosis0.21056710
74MP0003631_nervous_system_phenotype0.20981008
75MP0002084_abnormal_developmental_patter0.20728298
76MP0003879_abnormal_hair_cell0.19884587
77MP0000604_amyloidosis0.19818934
78MP0004133_heterotaxia0.19654791
79MP0006035_abnormal_mitochondrial_morpho0.18505116
80MP0006072_abnormal_retinal_apoptosis0.18303209
81MP0002736_abnormal_nociception_after0.17124363
82MP0001851_eye_inflammation0.16820726
83MP0002092_abnormal_eye_morphology0.16416284
84MP0005380_embryogenesis_phenotype0.15762551
85MP0001672_abnormal_embryogenesis/_devel0.15762551
86MP0005365_abnormal_bile_salt0.15400209
87MP0001697_abnormal_embryo_size0.14669108
88MP0000647_abnormal_sebaceous_gland0.14369842
89MP0002169_no_abnormal_phenotype0.14280157
90MP0000534_abnormal_ureter_morphology0.14200829
91MP0002229_neurodegeneration0.14154662
92MP0002873_normal_phenotype0.14037744
93MP0002970_abnormal_white_adipose0.14008517
94MP0005423_abnormal_somatic_nervous0.13888291
95MP0003942_abnormal_urinary_system0.13588283
96MP0005195_abnormal_posterior_eye0.13241931
97MP0001986_abnormal_taste_sensitivity0.13163269
98MP0003948_abnormal_gas_homeostasis0.12836579
99MP0002405_respiratory_system_inflammati0.12118044
100MP0000015_abnormal_ear_pigmentation0.12040042

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.61688171
2Abnormal respiratory motile cilium morphology (HP:0005938)9.23234438
3Abnormal respiratory epithelium morphology (HP:0012253)9.23234438
4Rhinitis (HP:0012384)8.00302240
5Abnormal ciliary motility (HP:0012262)7.76206106
6Chronic bronchitis (HP:0004469)7.60430521
7Nasal polyposis (HP:0100582)6.46246879
8Infertility (HP:0000789)6.35780488
9Abnormality of the nasal mucosa (HP:0000433)5.31295778
10Bronchiectasis (HP:0002110)4.59035278
11Bronchitis (HP:0012387)4.57232072
12Nephronophthisis (HP:0000090)4.21962198
13Recurrent sinusitis (HP:0011108)3.58099451
14Male infertility (HP:0003251)3.43357759
15Recurrent otitis media (HP:0000403)3.32367035
16Abnormality of the renal medulla (HP:0100957)3.22176684
17Abnormality of the lower motor neuron (HP:0002366)2.99472267
18Abnormal spermatogenesis (HP:0008669)2.93759078
19Gonadotropin excess (HP:0000837)2.85745058
20Tubulointerstitial nephritis (HP:0001970)2.82249437
21Medial flaring of the eyebrow (HP:0010747)2.80610763
22Recurrent bronchitis (HP:0002837)2.55099774
23Molar tooth sign on MRI (HP:0002419)2.51380731
24Abnormality of midbrain morphology (HP:0002418)2.51380731
25Tubular atrophy (HP:0000092)2.38761297
26Amyotrophic lateral sclerosis (HP:0007354)2.37160475
27Impulsivity (HP:0100710)2.31193380
28Tubulointerstitial abnormality (HP:0001969)2.29871302
29Fibular hypoplasia (HP:0003038)2.29156131
30Azoospermia (HP:0000027)2.15896339
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7360881
32Dynein arm defect of respiratory motile cilia (HP:0012255)13.1868007
33Absent/shortened dynein arms (HP:0200106)13.1868007
34Postaxial foot polydactyly (HP:0001830)1.97874017
35Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97411169
36Impaired proprioception (HP:0010831)1.88859016
37Stage 5 chronic kidney disease (HP:0003774)1.87195271
38Congenital primary aphakia (HP:0007707)1.82238198
39Gait imbalance (HP:0002141)1.81962764
40Chronic sinusitis (HP:0011109)1.81644503
41Congenital hepatic fibrosis (HP:0002612)1.76623466
42Tubulointerstitial fibrosis (HP:0005576)1.75814145
43Abnormality of the renal cortex (HP:0011035)1.72022410
44Abnormality of the dental root (HP:0006486)1.70264269
45Taurodontia (HP:0000679)1.70264269
46Abnormality of permanent molar morphology (HP:0011071)1.70264269
47Spastic tetraparesis (HP:0001285)1.69935690
48Short ribs (HP:0000773)1.69066044
49Upper motor neuron abnormality (HP:0002127)1.67316365
50Absent frontal sinuses (HP:0002688)1.65216158
51Oculomotor apraxia (HP:0000657)1.64662056
52Renal dysplasia (HP:0000110)1.64401985
53Abnormality of dentin (HP:0010299)1.63295030
54Microglossia (HP:0000171)1.60747806
55Heterotopia (HP:0002282)1.60379191
56Postaxial hand polydactyly (HP:0001162)1.60181648
57Abnormal drinking behavior (HP:0030082)1.59308440
58Polydipsia (HP:0001959)1.59308440
59Abnormality of molar (HP:0011077)1.58781819
60Abnormality of molar morphology (HP:0011070)1.58781819
61Supernumerary spleens (HP:0009799)1.58653092
62Facial cleft (HP:0002006)1.57833110
63Abnormal gallbladder physiology (HP:0012438)1.56527606
64Cholecystitis (HP:0001082)1.56527606
65Nephrogenic diabetes insipidus (HP:0009806)1.56003823
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55575445
67Absent epiphyses (HP:0010577)1.55575445
68Abnormality of the dental pulp (HP:0006479)1.55356443
69J-shaped sella turcica (HP:0002680)1.53905068
70Abnormality of renal excretion (HP:0011036)1.49247319
71Degeneration of anterior horn cells (HP:0002398)1.47860231
72Abnormality of the anterior horn cell (HP:0006802)1.47860231
73Aplasia/Hypoplasia of the lens (HP:0008063)1.47374624
74Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.45574454
75Dyschromatopsia (HP:0007641)1.44905878
76Aplasia/Hypoplasia of the fibula (HP:0006492)1.42918794
77Bell-shaped thorax (HP:0001591)1.40995314
78Poor coordination (HP:0002370)1.37197576
79Breast carcinoma (HP:0003002)1.36945616
80Cystic liver disease (HP:0006706)1.35743464
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.34782720
8211 pairs of ribs (HP:0000878)1.33269556
83Abnormality of ocular smooth pursuit (HP:0000617)1.32368259
84Vaginal atresia (HP:0000148)1.32168194
85Genital tract atresia (HP:0001827)1.30843385
86Short thorax (HP:0010306)1.30688094
87Median cleft lip (HP:0000161)1.29924396
88Deformed sella turcica (HP:0002681)1.28915587
89Abnormal biliary tract physiology (HP:0012439)1.26880276
90Bile duct proliferation (HP:0001408)1.26880276
91Pancreatic fibrosis (HP:0100732)1.25638932
92Decreased central vision (HP:0007663)1.25438105
93Cerebellar dysplasia (HP:0007033)1.25020425
94Broad distal phalanx of finger (HP:0009836)1.24012504
95Nephropathy (HP:0000112)1.20042397
96Pachygyria (HP:0001302)1.19047608
97Hypoplasia of dental enamel (HP:0006297)1.16629827
98Choroideremia (HP:0001139)1.14343427
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.13557666
100Abnormality of saccadic eye movements (HP:0000570)1.13086020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.15740398
2PDK49.15740398
3PDK25.94496866
4TESK14.63025692
5PRKD33.93828584
6ICK3.23648780
7PNCK2.26865863
8WNK42.26522950
9PTK2B2.26461409
10STK392.19489520
11NEK21.81155606
12STK381.35927573
13DYRK1B1.07515395
14WNK10.96345731
15PDK10.95321207
16TYRO30.92100494
17MAPK150.91289708
18PASK0.89768981
19CCNB10.88816490
20STK30.86239921
21IRAK10.74964854
22DYRK30.72992242
23CDC70.67030685
24TESK20.66814520
25TTK0.62488712
26WEE10.59810302
27LMTK20.59796210
28PLK40.56950052
29CHEK20.56932017
30CAMK1G0.51087655
31PINK10.50819170
32CHEK10.47985493
33ATR0.44218794
34CDK120.42004764
35MAP2K60.40187103
36PDPK10.38737546
37ATM0.33660852
38STK38L0.32369930
39EEF2K0.30835567
40PAK10.29308021
41NTRK20.28849322
42BMPR1B0.28414881
43MTOR0.26832757
44RIPK40.26364112
45IRAK20.25935109
46CAMKK10.25064621
47PLK10.24203969
48MUSK0.23922137
49PAK20.21710885
50PRKCG0.21057662
51BRSK20.20690668
52PRKAA10.18746915
53MAPKAPK50.18186655
54RPS6KB10.16357250
55MARK20.16330744
56NEK60.15274929
57MAP3K100.11518676
58CSNK1D0.08823002
59MARK30.08009131
60BRAF0.07701345
61PRKG10.07103844
62RIPK10.06759010
63WNK30.06289876
64CDK150.06119678
65PRKACG0.05909898
66CSNK2A10.05725622
67PAK40.05366534
68PRKCQ0.05138695
69PKN10.05135164
70YES10.04960623
71CDK10.04425673
72BRSK10.03947684
73PRKCZ0.03915509
74CDK180.03839731
75CDK20.03708797
76MAP3K40.03624727
77EGFR0.03543014
78GSK3B0.03285938
79CDK11A0.02825472
80PDGFRB0.02280438
81RPS6KA10.01923976
82MAPK80.01681524
83PRKDC0.01585522
84STK110.01391477
85CSNK2A20.01368057
86PRKACB0.01157389
87CDK140.00748074
88STK100.00600150
89CSF1R0.00213585
90MAPK10-0.0378588
91PRKCA-0.0291993
92CAMK2A-0.0236887
93CDK4-0.0204742
94CDK6-0.0188610
95CDK3-0.0183967
96RPS6KA3-0.0175449
97PAK6-0.0174397
98PRKCB-0.0089748
99ZAP70-0.0057534
100PRKG2-0.0002321

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.30647413
2Pyruvate metabolism_Homo sapiens_hsa006204.39120520
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34921253
4Propanoate metabolism_Homo sapiens_hsa006403.60184691
5Fatty acid biosynthesis_Homo sapiens_hsa000613.40367539
6Glucagon signaling pathway_Homo sapiens_hsa049222.92468235
7Basal transcription factors_Homo sapiens_hsa030222.79700403
8Selenocompound metabolism_Homo sapiens_hsa004502.68234615
9Pentose phosphate pathway_Homo sapiens_hsa000302.61192070
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40635157
11Linoleic acid metabolism_Homo sapiens_hsa005912.30542838
12Fanconi anemia pathway_Homo sapiens_hsa034602.19709061
13Dorso-ventral axis formation_Homo sapiens_hsa043202.15053163
14Oocyte meiosis_Homo sapiens_hsa041142.04435397
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.93648618
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79771636
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.74403051
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.72926276
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70535232
20Huntingtons disease_Homo sapiens_hsa050161.67365346
21Amphetamine addiction_Homo sapiens_hsa050311.61624079
22Carbon metabolism_Homo sapiens_hsa012001.48829598
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41342502
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41172303
25Fructose and mannose metabolism_Homo sapiens_hsa000511.39752377
26Renin secretion_Homo sapiens_hsa049241.34626826
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.25337756
28RNA transport_Homo sapiens_hsa030131.21150119
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21097475
30Cardiac muscle contraction_Homo sapiens_hsa042601.19648939
31mRNA surveillance pathway_Homo sapiens_hsa030151.18846594
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10313932
33Fatty acid metabolism_Homo sapiens_hsa012121.05054958
34Antigen processing and presentation_Homo sapiens_hsa046121.04690891
35Fat digestion and absorption_Homo sapiens_hsa049751.04322989
36Biosynthesis of amino acids_Homo sapiens_hsa012301.03460320
37Purine metabolism_Homo sapiens_hsa002301.01993112
38Ether lipid metabolism_Homo sapiens_hsa005651.00853185
39Mineral absorption_Homo sapiens_hsa049780.99866963
40Fatty acid degradation_Homo sapiens_hsa000710.99663884
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93370115
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90252405
43Long-term potentiation_Homo sapiens_hsa047200.88624517
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87914569
45* PPAR signaling pathway_Homo sapiens_hsa033200.81995966
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81491216
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80606566
48* Glycerolipid metabolism_Homo sapiens_hsa005610.79474546
49Glutathione metabolism_Homo sapiens_hsa004800.77621837
50ABC transporters_Homo sapiens_hsa020100.75295471
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73796605
52Collecting duct acid secretion_Homo sapiens_hsa049660.69807623
53Chemical carcinogenesis_Homo sapiens_hsa052040.68920923
54N-Glycan biosynthesis_Homo sapiens_hsa005100.67142008
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66460921
56Estrogen signaling pathway_Homo sapiens_hsa049150.65846209
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.60819321
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60739844
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59136997
60Calcium signaling pathway_Homo sapiens_hsa040200.59127559
61VEGF signaling pathway_Homo sapiens_hsa043700.52402989
62Systemic lupus erythematosus_Homo sapiens_hsa053220.52165111
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.50541373
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49818407
65Insulin secretion_Homo sapiens_hsa049110.49161908
66Inositol phosphate metabolism_Homo sapiens_hsa005620.47541679
67Arachidonic acid metabolism_Homo sapiens_hsa005900.46561819
68Hedgehog signaling pathway_Homo sapiens_hsa043400.45232722
69Renin-angiotensin system_Homo sapiens_hsa046140.44772141
70Legionellosis_Homo sapiens_hsa051340.44318488
71Bile secretion_Homo sapiens_hsa049760.44034773
72AMPK signaling pathway_Homo sapiens_hsa041520.42758190
73Thyroid hormone synthesis_Homo sapiens_hsa049180.42669933
74Synaptic vesicle cycle_Homo sapiens_hsa047210.36361764
75Endocytosis_Homo sapiens_hsa041440.36341034
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35219237
77* Metabolic pathways_Homo sapiens_hsa011000.34466253
78Taste transduction_Homo sapiens_hsa047420.32791725
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31064655
80Protein digestion and absorption_Homo sapiens_hsa049740.27285526
81B cell receptor signaling pathway_Homo sapiens_hsa046620.26506936
82Circadian entrainment_Homo sapiens_hsa047130.25254203
83Pyrimidine metabolism_Homo sapiens_hsa002400.24044435
84Homologous recombination_Homo sapiens_hsa034400.23781979
85Pancreatic secretion_Homo sapiens_hsa049720.23521691
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.23363330
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21613078
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20996465
89cAMP signaling pathway_Homo sapiens_hsa040240.20059830
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19917203
91Gastric acid secretion_Homo sapiens_hsa049710.19523877
92Salivary secretion_Homo sapiens_hsa049700.19367271
93Wnt signaling pathway_Homo sapiens_hsa043100.18259656
94RNA degradation_Homo sapiens_hsa030180.18060863
95Viral carcinogenesis_Homo sapiens_hsa052030.17896514
96Retinol metabolism_Homo sapiens_hsa008300.17488720
97Alcoholism_Homo sapiens_hsa050340.17165602
98Cell cycle_Homo sapiens_hsa041100.15983496
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.13076401
100Sulfur metabolism_Homo sapiens_hsa009200.09252781

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