GKN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride catabolic process (GO:0019433)9.73428597
2fibril organization (GO:0097435)9.52730167
3glutathione derivative biosynthetic process (GO:1901687)8.81792228
4glutathione derivative metabolic process (GO:1901685)8.81792228
5O-glycan processing (GO:0016266)8.67638798
6response to iron ion (GO:0010039)8.66813674
7neutral lipid catabolic process (GO:0046461)8.64207712
8acylglycerol catabolic process (GO:0046464)8.64207712
9* digestion (GO:0007586)8.56291745
10digestive system process (GO:0022600)8.26419514
11biotin metabolic process (GO:0006768)8.17056496
12sulfation (GO:0051923)7.92869939
13protein autoprocessing (GO:0016540)7.78174149
14lipid storage (GO:0019915)7.72486127
15fatty acid homeostasis (GO:0055089)7.52694163
16lipid particle organization (GO:0034389)7.27114486
17bundle of His cell to Purkinje myocyte communication (GO:0086069)7.14917229
18regulation of triglyceride catabolic process (GO:0010896)6.98719425
19glandular epithelial cell differentiation (GO:0002067)6.88960794
20cellular response to cadmium ion (GO:0071276)6.78361176
21negative regulation of digestive system process (GO:0060457)6.69667288
22kidney morphogenesis (GO:0060993)6.48825220
233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.32956979
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.32956979
25positive regulation of lipid storage (GO:0010884)6.16584024
26protein O-linked glycosylation (GO:0006493)6.16324805
27glycerolipid catabolic process (GO:0046503)6.15716895
28CDP-diacylglycerol biosynthetic process (GO:0016024)6.15706425
29regulation of proton transport (GO:0010155)6.09357258
30triglyceride metabolic process (GO:0006641)5.94562948
31CDP-diacylglycerol metabolic process (GO:0046341)5.93914410
32triglyceride biosynthetic process (GO:0019432)5.92658435
33production of molecular mediator of immune response (GO:0002440)5.78654032
34fatty-acyl-CoA biosynthetic process (GO:0046949)5.78407361
35acylglycerol biosynthetic process (GO:0046463)5.65552571
36neutral lipid biosynthetic process (GO:0046460)5.65552571
37acylglycerol metabolic process (GO:0006639)5.56728950
38neutral lipid metabolic process (GO:0006638)5.49274230
39L-fucose catabolic process (GO:0042355)5.30468818
40fucose catabolic process (GO:0019317)5.30468818
41L-fucose metabolic process (GO:0042354)5.30468818
42intestinal absorption (GO:0050892)5.13519084
43fatty-acyl-CoA metabolic process (GO:0035337)5.13164878
44positive regulation of triglyceride metabolic process (GO:0090208)5.09901015
45negative regulation of execution phase of apoptosis (GO:1900118)5.07969357
46oxaloacetate metabolic process (GO:0006107)4.94676258
47regulation of lipid storage (GO:0010883)4.93371839
48negative regulation of lipid catabolic process (GO:0050995)4.90612915
49thyroid hormone metabolic process (GO:0042403)4.83484868
50thioester biosynthetic process (GO:0035384)4.82957347
51acyl-CoA biosynthetic process (GO:0071616)4.82957347
52sulfur amino acid catabolic process (GO:0000098)4.74181091
53protein heterotrimerization (GO:0070208)4.68435208
54negative regulation of lipid storage (GO:0010888)4.64017268
55glutathione metabolic process (GO:0006749)4.62947641
56carnitine shuttle (GO:0006853)4.52153666
57white fat cell differentiation (GO:0050872)4.49146480
58response to phenylpropanoid (GO:0080184)4.48369586
59thyroid hormone generation (GO:0006590)4.47297288
60positive regulation of lipid catabolic process (GO:0050996)4.46914467
61long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.45712714
62phospholipid scrambling (GO:0017121)4.39988514
63NADH metabolic process (GO:0006734)4.31782661
64regulation of lipid catabolic process (GO:0050994)4.16862013
65plasma lipoprotein particle clearance (GO:0034381)4.10688221
66acetyl-CoA metabolic process (GO:0006084)4.03643449
67xenobiotic metabolic process (GO:0006805)4.03611784
68fatty acid transmembrane transport (GO:1902001)4.01092387
69ventricular cardiac muscle cell action potential (GO:0086005)4.00026231
70phosphatidic acid metabolic process (GO:0046473)3.94218069
71phosphatidic acid biosynthetic process (GO:0006654)3.94218069
72nitric oxide biosynthetic process (GO:0006809)3.93253602
73ovulation cycle (GO:0042698)3.92790529
74response to dietary excess (GO:0002021)3.90630470
75valine metabolic process (GO:0006573)3.87757637
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.85934527
77receptor recycling (GO:0001881)3.84585993
78phosphatidylserine acyl-chain remodeling (GO:0036150)3.82006701
79lung secretory cell differentiation (GO:0061140)3.81298267
80skeletal muscle organ development (GO:0060538)3.79672218
81brown fat cell differentiation (GO:0050873)3.76912570
82regulation of execution phase of apoptosis (GO:1900117)3.75411716
83long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.74527015
84regulation of triglyceride metabolic process (GO:0090207)3.67862586
85regulation of pH (GO:0006885)3.66024380
86alanine transport (GO:0032328)3.65629362
87negative regulation of granulocyte differentiation (GO:0030853)3.63802442
88positive regulation of glomerulus development (GO:0090193)3.60764469
89cellular response to gonadotropin stimulus (GO:0071371)3.58347324
90regulation of phospholipase A2 activity (GO:0032429)3.57801141
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.54610673
92receptor guanylyl cyclase signaling pathway (GO:0007168)3.48722533
93cyclooxygenase pathway (GO:0019371)3.48688924
94atrioventricular valve morphogenesis (GO:0003181)3.48608816
95cellular response to arsenic-containing substance (GO:0071243)3.47791945
96response to zinc ion (GO:0010043)3.46766502
97phosphatidylserine metabolic process (GO:0006658)3.46633342
98removal of superoxide radicals (GO:0019430)3.45463384
99cellular response to superoxide (GO:0071451)3.45463384
100cellular response to oxygen radical (GO:0071450)3.45463384
101positive regulation of p38MAPK cascade (GO:1900745)3.44432876
102positive regulation of fatty acid metabolic process (GO:0045923)3.41509020
103positive regulation of urine volume (GO:0035810)3.41483065
104regulation of glycogen (starch) synthase activity (GO:2000465)3.37322790
105negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.36671932
106negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.34834211
107columnar/cuboidal epithelial cell differentiation (GO:0002065)3.34377797
108retinol metabolic process (GO:0042572)3.32965135
109acrosome reaction (GO:0007340)3.32570546
110embryonic foregut morphogenesis (GO:0048617)3.32424975
111negative regulation of smooth muscle cell proliferation (GO:0048662)3.32344468
112leukotriene metabolic process (GO:0006691)3.32195515
113positive regulation of fatty acid oxidation (GO:0046321)3.31879781
114diacylglycerol metabolic process (GO:0046339)3.31718250
115growth hormone receptor signaling pathway (GO:0060396)3.30822249
116positive regulation of metanephros development (GO:0072216)3.30089289
117acyl-CoA metabolic process (GO:0006637)3.26726340
118thioester metabolic process (GO:0035383)3.26726340
119intestinal epithelial cell development (GO:0060576)3.26110497
120trophoblast giant cell differentiation (GO:0060707)3.25148108
121ovulation from ovarian follicle (GO:0001542)3.24420820
122negative regulation of protein autophosphorylation (GO:0031953)3.24410163
123primary alcohol metabolic process (GO:0034308)3.23195336
124cytoskeletal anchoring at plasma membrane (GO:0007016)3.22620501
125regulation of heart rate by cardiac conduction (GO:0086091)3.22408275
126carnitine transmembrane transport (GO:1902603)3.22300633
127negative regulation of smooth muscle cell migration (GO:0014912)3.22087715
128coenzyme A biosynthetic process (GO:0015937)3.21822716
129regulation of cardioblast differentiation (GO:0051890)3.18317509
130vitamin transmembrane transport (GO:0035461)3.17713261
131L-serine transport (GO:0015825)3.17296063
132tricarboxylic acid metabolic process (GO:0072350)3.16793574
133response to hydroperoxide (GO:0033194)3.15881830
134negative regulation of norepinephrine secretion (GO:0010700)3.14752857
135regulation of macrophage activation (GO:0043030)3.12821586
136negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.10337094
137acylglycerol homeostasis (GO:0055090)3.09635580
138triglyceride homeostasis (GO:0070328)3.09635580
139ethanol oxidation (GO:0006069)3.05325466
140regulation of cholesterol storage (GO:0010885)3.05318339
141response to superoxide (GO:0000303)3.03915431
142positive regulation of cholesterol efflux (GO:0010875)3.03692440
143negative regulation of macrophage differentiation (GO:0045650)3.03608100
144ethanol metabolic process (GO:0006067)3.03243794
145regulation of cAMP-dependent protein kinase activity (GO:2000479)3.03100244
146cell communication involved in cardiac conduction (GO:0086065)3.02008563
147fucose metabolic process (GO:0006004)2.99008931
148nucleoside bisphosphate metabolic process (GO:0033865)2.98261425
149purine nucleoside bisphosphate metabolic process (GO:0034032)2.98261425
150ribonucleoside bisphosphate metabolic process (GO:0033875)2.98261425
151protein retention in ER lumen (GO:0006621)2.96551547
152cAMP biosynthetic process (GO:0006171)2.91603034
153regulation of p38MAPK cascade (GO:1900744)2.91551904
154negative regulation of platelet activation (GO:0010544)2.90022357
155temperature homeostasis (GO:0001659)2.89362238
156negative regulation of tumor necrosis factor production (GO:0032720)2.89328928
157sodium ion export (GO:0071436)2.88827991
158alditol phosphate metabolic process (GO:0052646)2.87348075
159cardiac conduction (GO:0061337)2.85240499
160desmosome organization (GO:0002934)2.85101939
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83040736
162response to oxygen radical (GO:0000305)2.82552474
163pH reduction (GO:0045851)2.81045155
164nucleotide-sugar biosynthetic process (GO:0009226)2.80557935
165flavonoid metabolic process (GO:0009812)2.79400025
166peptidyl-proline hydroxylation (GO:0019511)2.79199625
167serine transport (GO:0032329)2.73079012
168leukotriene biosynthetic process (GO:0019370)2.72766706
169phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.71584949
170acid secretion (GO:0046717)2.69820963
171hexose catabolic process (GO:0019320)2.68234691
172hepatocyte apoptotic process (GO:0097284)2.67983613
173phosphatidylinositol acyl-chain remodeling (GO:0036149)2.67919539
174phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.66145667
175epithelial cell-cell adhesion (GO:0090136)2.65833650
176response to gonadotropin (GO:0034698)2.65426481
177regulation of transforming growth factor beta1 production (GO:0032908)2.65240316
178regulation of skeletal muscle contraction (GO:0014819)2.64811272
179cellular glucuronidation (GO:0052695)2.58546472
180hormone catabolic process (GO:0042447)2.58235578
181GDP-mannose metabolic process (GO:0019673)2.57892357
182xenobiotic catabolic process (GO:0042178)2.57777158
183negative regulation of cholesterol transport (GO:0032375)2.45450780
184negative regulation of sterol transport (GO:0032372)2.45450780
185synaptic transmission, cholinergic (GO:0007271)2.44816270
186monovalent inorganic cation homeostasis (GO:0055067)2.43413512
187endocardial cushion development (GO:0003197)2.42603761
188uronic acid metabolic process (GO:0006063)2.42377021
189glucuronate metabolic process (GO:0019585)2.42377021
190maintenance of gastrointestinal epithelium (GO:0030277)19.3264725
191epithelial structure maintenance (GO:0010669)14.5198433
192regulation of sequestering of triglyceride (GO:0010889)13.0535681
193extracellular fibril organization (GO:0043206)11.0829720
194cellular response to zinc ion (GO:0071294)10.6634878
195low-density lipoprotein particle clearance (GO:0034383)10.5618890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human7.64109140
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse5.76202775
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.88138574
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.36503789
5ESR1_21235772_ChIP-Seq_MCF-7_Human4.31380017
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.96760471
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.86809733
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.38048210
9GATA4_25053715_ChIP-Seq_YYC3_Human3.01500556
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.99404594
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.70552059
12SOX2_20726797_ChIP-Seq_SW620_Human2.63007986
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61337534
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.58766908
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50139524
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.48512718
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.46467370
18ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.46204182
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.38029792
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34535293
21GATA6_25053715_ChIP-Seq_YYC3_Human2.25952186
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.23895552
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17991647
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.15746824
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05391972
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.02129027
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.99044471
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.95587275
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91914364
30AHR_22903824_ChIP-Seq_MCF-7_Human1.91130025
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86676365
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86203177
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.82812689
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.80907740
35KLF5_25053715_ChIP-Seq_YYC3_Human1.78072745
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.76277449
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.75599988
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.66253528
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63317144
40LXR_22292898_ChIP-Seq_THP-1_Human1.61089103
41VDR_22108803_ChIP-Seq_LS180_Human1.60813499
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58068450
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58068450
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58068450
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.56807506
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56415194
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.56166283
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55942542
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53230814
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.51842177
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50291536
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48988072
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48689087
54SMC3_22415368_ChIP-Seq_MEFs_Mouse1.48585115
55RACK7_27058665_Chip-Seq_MCF-7_Human1.48448283
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47304193
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45953017
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44672447
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44504507
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.43979389
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42902636
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41986981
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40031363
64IGF1R_20145208_ChIP-Seq_DFB_Human1.39627172
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38453368
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33734973
67SA1_22415368_ChIP-Seq_MEFs_Mouse1.32944355
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31113707
69PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.30741352
70ZNF263_19887448_ChIP-Seq_K562_Human1.30282182
71PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.30134656
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28410612
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25951565
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21276642
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20551888
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19820122
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.19123531
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18600573
79* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18552342
80* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18552342
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.18484020
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.17939629
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16612396
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.16123139
85EGR1_19032775_ChIP-ChIP_M12_Human1.15378359
86RXR_22108803_ChIP-Seq_LS180_Human1.15256491
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15220189
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.13237122
89KDM2B_26808549_Chip-Seq_K562_Human1.13118439
90ZNF274_21170338_ChIP-Seq_K562_Hela1.12897744
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10307509
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09973069
93VDR_21846776_ChIP-Seq_THP-1_Human1.08924619
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08808327
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07981924
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06948738
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.05852476
98BCAT_22108803_ChIP-Seq_LS180_Human1.03210897
99ATF3_27146783_Chip-Seq_COLON_Human1.02861005
100CLOCK_20551151_ChIP-Seq_293T_Human1.02830173
101DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01204472
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99259192
103* STAT1_20625510_ChIP-Seq_HELA_Human0.99163165
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98910313
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98851664
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98522765
107CJUN_26792858_Chip-Seq_BT549_Human0.96450045
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95159171
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95074136
110CBP_21632823_ChIP-Seq_H3396_Human0.94871502
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94564262
112KLF4_19829295_ChIP-Seq_ESCs_Human0.94186047
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93875705
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93129477
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92850310
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92299887
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91315373
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.90292775
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90103818
120MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90055789
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89048226
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88713109
123RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88443619
124EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88443619
125P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88084064
126SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.86720095
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.86304874
128KDM2B_26808549_Chip-Seq_DND41_Human0.85079123
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.83993684
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83820082
131VDR_24763502_ChIP-Seq_THP-1_Human0.83564202
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83546693
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83433696
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.83302664
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83246402
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83154862
137SA1_27219007_Chip-Seq_Bcells_Human0.83151177
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.82866336
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.82866336
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82583021
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80113351
142P53_21459846_ChIP-Seq_SAOS-2_Human0.80067923
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79765160
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78606513
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78606513
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78166541
147P68_20966046_ChIP-Seq_HELA_Human0.77958922
148TP63_22573176_ChIP-Seq_HFKS_Human0.77549525
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77077173
150MYC_19829295_ChIP-Seq_ESCs_Human0.75557312
151JARID2_20075857_ChIP-Seq_MESCs_Mouse0.75078791
152NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75003848
153ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74533455
154TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74292185
155GATA1_19941826_ChIP-Seq_K562_Human0.74269926
156CREB1_26743006_Chip-Seq_LNCaP_Human0.73486881
157SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73451854
158SMC4_20622854_ChIP-Seq_HELA_Human0.73144218
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71164214
160CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71061033
161EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70349817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.15724239
2MP0001873_stomach_inflammation6.33658500
3MP0005666_abnormal_adipose_tissue5.61982691
4MP0002971_abnormal_brown_adipose5.29219037
5MP0001664_abnormal_digestion5.10489149
6MP0000470_abnormal_stomach_morphology3.81944421
7MP0005375_adipose_tissue_phenotype3.74255692
8MP0003806_abnormal_nucleotide_metabolis3.57011420
9MP0005535_abnormal_body_temperature3.13753452
10MP0006138_congestive_heart_failure3.10622902
11MP0005334_abnormal_fat_pad3.02079891
12MP0009115_abnormal_fat_cell2.48350271
13MP0000343_altered_response_to2.24129658
14MP0001663_abnormal_digestive_system2.22511569
15MP0003959_abnormal_lean_body2.18464636
16MP0005448_abnormal_energy_balance2.06272254
17MP0010368_abnormal_lymphatic_system2.02233874
18MP0008004_abnormal_stomach_pH17.4430280
19MP0005381_digestive/alimentary_phenotyp1.93936438
20MP0003828_pulmonary_edema1.93354932
21MP0002295_abnormal_pulmonary_circulatio1.90744382
22MP0004084_abnormal_cardiac_muscle1.86594523
23MP0010234_abnormal_vibrissa_follicle1.84799702
24MP0005452_abnormal_adipose_tissue1.84663006
25MP0005165_increased_susceptibility_to1.73309343
26MP0005647_abnormal_sex_gland1.73072032
27MP0001661_extended_life_span1.67459060
28MP0001879_abnormal_lymphatic_vessel1.63703656
29MP0003303_peritoneal_inflammation1.61747460
30MP0005084_abnormal_gallbladder_morpholo1.46501359
31MP0000003_abnormal_adipose_tissue1.45742550
32MP0002254_reproductive_system_inflammat1.44965836
33MP0000751_myopathy1.41971524
34MP0005167_abnormal_blood-brain_barrier1.37564187
35MP0001666_abnormal_nutrient_absorption1.34144470
36MP0003948_abnormal_gas_homeostasis1.33833532
37MP0003221_abnormal_cardiomyocyte_apopto1.32892613
38MP0009278_abnormal_bone_marrow1.30675214
39MP0000477_abnormal_intestine_morphology1.30005401
40MP0005595_abnormal_vascular_smooth1.28754351
41MP0004264_abnormal_extraembryonic_tissu1.27699916
42MP0005083_abnormal_biliary_tract1.22938068
43MP0002138_abnormal_hepatobiliary_system1.18272711
44MP0005645_abnormal_hypothalamus_physiol1.17581685
45MP0003283_abnormal_digestive_organ1.16659289
46MP0001727_abnormal_embryo_implantation1.16147607
47MP0005164_abnormal_response_to1.11796679
48MP0003186_abnormal_redox_activity1.10711777
49MP0006054_spinal_hemorrhage1.09991408
50MP0008775_abnormal_heart_ventricle1.06675504
51MP0004036_abnormal_muscle_relaxation1.04643175
52MP0001545_abnormal_hematopoietic_system1.04421444
53MP0005397_hematopoietic_system_phenotyp1.04421444
54MP0005385_cardiovascular_system_phenoty1.02108587
55MP0001544_abnormal_cardiovascular_syste1.02108587
56MP0002876_abnormal_thyroid_physiology0.99491219
57MP0003705_abnormal_hypodermis_morpholog0.98787159
58MP0003011_delayed_dark_adaptation0.97600258
59MP0005085_abnormal_gallbladder_physiolo0.97252624
60MP0000249_abnormal_blood_vessel0.95851739
61MP0002909_abnormal_adrenal_gland0.94432676
62MP0000462_abnormal_digestive_system0.92273360
63MP0009672_abnormal_birth_weight0.88377638
64MP0001764_abnormal_homeostasis0.85595463
65MP0008438_abnormal_cutaneous_collagen0.82759331
66MP0006036_abnormal_mitochondrial_physio0.82576326
67MP0009384_cardiac_valve_regurgitation0.80584089
68MP0000490_abnormal_crypts_of0.79146573
69MP0005365_abnormal_bile_salt0.78143426
70MP0001944_abnormal_pancreas_morphology0.77662120
71MP0000767_abnormal_smooth_muscle0.77306758
72MP0005636_abnormal_mineral_homeostasis0.73633765
73MP0000537_abnormal_urethra_morphology0.72561125
74MP0001542_abnormal_bone_strength0.72169667
75MP0001881_abnormal_mammary_gland0.71600422
76MP0004510_myositis0.70432607
77MP0008875_abnormal_xenobiotic_pharmacok0.70283570
78MP0002638_abnormal_pupillary_reflex0.69978450
79MP0005266_abnormal_metabolism0.68016699
80MP0004858_abnormal_nervous_system0.66955731
81MP0002972_abnormal_cardiac_muscle0.65558688
82MP0004087_abnormal_muscle_fiber0.64832820
83MP0000230_abnormal_systemic_arterial0.63913860
84MP0002234_abnormal_pharynx_morphology0.63315851
85MP0002877_abnormal_melanocyte_morpholog0.62818417
86MP0004484_altered_response_of0.61705405
87MP0004185_abnormal_adipocyte_glucose0.59742834
88MP0005409_darkened_coat_color0.59508408
89MP0003879_abnormal_hair_cell0.58308890
90MP0003279_aneurysm0.58028689
91MP0010155_abnormal_intestine_physiology0.57958911
92MP0002069_abnormal_eating/drinking_beha0.57891643
93MP0010329_abnormal_lipoprotein_level0.57482934
94MP0000759_abnormal_skeletal_muscle0.57427827
95MP0010630_abnormal_cardiac_muscle0.56143344
96MP0003950_abnormal_plasma_membrane0.55926115
97MP0002796_impaired_skin_barrier0.54850683
98MP0000467_abnormal_esophagus_morphology0.54451596
99MP0002128_abnormal_blood_circulation0.53988889
100MP0003448_altered_tumor_morphology0.53690226
101MP0003075_altered_response_to0.53174999
102MP0004782_abnormal_surfactant_physiolog0.52969321
103MP0002139_abnormal_hepatobiliary_system0.51583621
104MP0009840_abnormal_foam_cell0.50564487
105MP0000858_altered_metastatic_potential0.50290844
106MP0009703_decreased_birth_body0.49472873
107MP0002998_abnormal_bone_remodeling0.48996074
108MP0001533_abnormal_skeleton_physiology0.48747794
109MP0001243_abnormal_dermal_layer0.47637031
110MP0004947_skin_inflammation0.46328330
111MP0003566_abnormal_cell_adhesion0.44881091
112MP0003868_abnormal_feces_composition0.43759001
113MP0002009_preneoplasia0.43717288
114MP0002019_abnormal_tumor_incidence0.39711612
115MP0003329_amyloid_beta_deposits0.39698331
116MP0008873_increased_physiological_sensi0.39193062
117MP0003866_abnormal_defecation0.39095494
118MP0002693_abnormal_pancreas_physiology0.36932083
119MP0002118_abnormal_lipid_homeostasis0.36855740
120MP0003119_abnormal_digestive_system0.36120787
121MP0010678_abnormal_skin_adnexa0.35638416
122MP0005166_decreased_susceptibility_to0.35582667
123MP0001849_ear_inflammation0.35480208
124MP0009780_abnormal_chondrocyte_physiolo0.35438650
125MP0001216_abnormal_epidermal_layer0.35361333
126MP0002078_abnormal_glucose_homeostasis0.34593422
127MP0003953_abnormal_hormone_level0.34425170
128MP0002060_abnormal_skin_morphology0.34120442
129MP0003191_abnormal_cellular_cholesterol0.33696107
130MP0005584_abnormal_enzyme/coenzyme_acti0.33361910
131MP0010352_gastrointestinal_tract_polyps0.32489547
132MP0001845_abnormal_inflammatory_respons0.31281401
133MP0003453_abnormal_keratinocyte_physiol0.30937709
134MP0003724_increased_susceptibility_to0.30909845
135MP0003252_abnormal_bile_duct0.29376449
136MP0000609_abnormal_liver_physiology0.29292209
137MP0003638_abnormal_response/metabolism_0.28216010
138MP0005408_hypopigmentation0.25796248
139MP0000367_abnormal_coat/_hair0.24921558
140MP0005275_abnormal_skin_tensile0.24739566
141MP0005501_abnormal_skin_physiology0.24399431
142MP0005319_abnormal_enzyme/_coenzyme0.24196749
143MP0000598_abnormal_liver_morphology0.24148909
144MP0005376_homeostasis/metabolism_phenot0.22689969
145MP0004272_abnormal_basement_membrane0.22547429
146MP0009642_abnormal_blood_homeostasis0.22302496
147MP0008961_abnormal_basal_metabolism0.21838024
148MP0002970_abnormal_white_adipose0.21327426
149MP0000604_amyloidosis0.20869407
150MP0005464_abnormal_platelet_physiology0.20540039
151MP0004043_abnormal_pH_regulation0.19858973
152MP0000013_abnormal_adipose_tissue0.19746281
153MP0010771_integument_phenotype0.19415119
154MP0005332_abnormal_amino_acid0.19002754
155MP0005360_urolithiasis0.18451496
156MP0004130_abnormal_muscle_cell0.18195801
157MP0005310_abnormal_salivary_gland0.17906380
158MP0009053_abnormal_anal_canal0.16792481
159MP0009931_abnormal_skin_appearance0.16173344
160MP0004859_abnormal_synaptic_plasticity0.15531792
161MP0005076_abnormal_cell_differentiation0.15488007
162MP0001191_abnormal_skin_condition0.15469313
163MP0002098_abnormal_vibrissa_morphology0.15250921
164MP0004019_abnormal_vitamin_homeostasis0.14811931
165MP0009643_abnormal_urine_homeostasis0.14565901
166MP0005367_renal/urinary_system_phenotyp0.14033193
167MP0000516_abnormal_urinary_system0.14033193
168MP0003690_abnormal_glial_cell0.13384164
169MP0000465_gastrointestinal_hemorrhage0.13332999
170MP0003656_abnormal_erythrocyte_physiolo0.12978060

Predicted human phenotypes

RankGene SetZ-score
1Hypertriglyceridemia (HP:0002155)9.31565276
2Acanthosis nigricans (HP:0000956)8.17270603
3Abnormal number of erythroid precursors (HP:0012131)7.97505799
4Difficulty running (HP:0009046)7.77458220
5Long foot (HP:0001833)7.58365076
6Oligomenorrhea (HP:0000876)7.21496613
7Abnormality of cells of the erythroid lineage (HP:0012130)7.13858941
8Insulin-resistant diabetes mellitus (HP:0000831)6.04000758
9Insulin resistance (HP:0000855)5.75720910
10Increased muscle lipid content (HP:0009058)5.26653213
11Palpitations (HP:0001962)4.71414831
12Bone cyst (HP:0012062)4.70600139
13Polyphagia (HP:0002591)4.64645775
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.59892265
15Abnormality of alanine metabolism (HP:0010916)4.59892265
16Hyperalaninemia (HP:0003348)4.59892265
17Increased serum pyruvate (HP:0003542)4.52084303
18Woolly hair (HP:0002224)4.37684273
19Goiter (HP:0000853)4.24109231
20Syncope (HP:0001279)4.20941654
21Abnormality of glycolysis (HP:0004366)4.17240518
22Easy fatigability (HP:0003388)3.97667625
23Complement deficiency (HP:0004431)3.96147631
24Gout (HP:0001997)3.85457018
25Prominent supraorbital ridges (HP:0000336)3.83408238
26Intrahepatic cholestasis (HP:0001406)3.83237992
27Megaloblastic anemia (HP:0001889)3.75776981
28Epidermoid cyst (HP:0200040)3.72888599
29Abnormality of complement system (HP:0005339)3.65142995
30Neck muscle weakness (HP:0000467)3.58661013
31Abnormality of purine metabolism (HP:0004352)3.57746500
32Abnormality of the vitamin B12 metabolism (HP:0004341)3.51332339
33Myocardial infarction (HP:0001658)3.49963448
34Back pain (HP:0003418)3.45434406
35Large hands (HP:0001176)3.36245056
36Abnormality of vitamin B metabolism (HP:0004340)3.31268069
37Frequent falls (HP:0002359)3.29721462
38Clitoromegaly (HP:0000057)3.25946145
39Abnormality of vitamin metabolism (HP:0100508)3.21283327
40Protrusio acetabuli (HP:0003179)3.15320227
41Hyperlipoproteinemia (HP:0010980)3.14121331
42Arterial tortuosity (HP:0005116)3.10990332
43Reduced subcutaneous adipose tissue (HP:0003758)3.08915513
44Lymphangioma (HP:0100764)3.07444773
45Ventricular fibrillation (HP:0001663)3.07085921
46Flat acetabular roof (HP:0003180)3.00831805
47Hemiplegia (HP:0002301)2.98703512
48Glomerulosclerosis (HP:0000096)2.94904358
49Ventricular arrhythmia (HP:0004308)2.94304173
50Abnormal eating behavior (HP:0100738)2.92387035
51Metaphyseal dysplasia (HP:0100255)2.91105547
52Skin nodule (HP:0200036)2.87340052
53Ventricular tachycardia (HP:0004756)2.84778628
54Abnormality of the periventricular white matter (HP:0002518)2.82442932
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74268193
56Accelerated skeletal maturation (HP:0005616)2.74260953
57Vascular tortuosity (HP:0004948)2.73822622
58Nausea (HP:0002018)2.70530446
59Hemorrhage of the eye (HP:0011885)2.70212041
60Micronodular cirrhosis (HP:0001413)2.66648592
61Agitation (HP:0000713)2.65638202
62Deep venous thrombosis (HP:0002625)2.55213330
63Axonal loss (HP:0003447)2.55007936
64Gowers sign (HP:0003391)2.51863325
65Increased purine levels (HP:0004368)2.47432538
66Hyperuricemia (HP:0002149)2.47432538
67Atrophic scars (HP:0001075)2.46183098
68Abnormality of the gastric mucosa (HP:0004295)2.45277376
69Infantile muscular hypotonia (HP:0008947)2.44483843
70Ileus (HP:0002595)2.44236292
71Vascular calcification (HP:0004934)2.42213076
72Lipoatrophy (HP:0100578)2.41026964
73Abnormal cartilage morphology (HP:0002763)2.40218531
74Abnormality of the labia (HP:0000058)2.39794721
75Systemic lupus erythematosus (HP:0002725)2.37032805
76Pancreatitis (HP:0001733)2.36941137
77Opisthotonus (HP:0002179)2.36022299
78Conjugated hyperbilirubinemia (HP:0002908)2.34613938
79Persistence of primary teeth (HP:0006335)2.34587566
80Focal segmental glomerulosclerosis (HP:0000097)2.33215402
81Aortic dissection (HP:0002647)2.27467884
82Curly hair (HP:0002212)2.26543443
83Esophageal varix (HP:0002040)2.25986969
84Cardiovascular calcification (HP:0011915)2.25425660
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.23044872
86Increased variability in muscle fiber diameter (HP:0003557)2.22499293
87Polycythemia (HP:0001901)2.19966111
88Sudden cardiac death (HP:0001645)2.17766505
89Resting tremor (HP:0002322)2.16729635
90Abdominal distention (HP:0003270)2.13787524
91Hyperpituitarism (HP:0010514)2.12095854
92Fragile nails (HP:0001808)2.10731277
93Difficulty walking (HP:0002355)2.07144394
94Stridor (HP:0010307)2.06977449
95Cupped ribs (HP:0000887)2.06668616
96Sensorimotor neuropathy (HP:0007141)2.05998457
97Abnormality of nucleobase metabolism (HP:0010932)2.04803189
98Milia (HP:0001056)2.03149896
99Pustule (HP:0200039)2.01588792
100Abnormality of the Achilles tendon (HP:0005109)2.01304221
101Achilles tendon contracture (HP:0001771)2.00573712
102Abnormality of skeletal muscle fiber size (HP:0012084)2.00486663
103Right ventricular cardiomyopathy (HP:0011663)10.3556875
104Abnormality of the clitoris (HP:0000056)1.99743770
105Ankyloglossia (HP:0010296)1.99670947
106Premature rupture of membranes (HP:0001788)1.98892486
107Fasciculations (HP:0002380)1.98853701
108Generalized hypopigmentation of hair (HP:0011358)1.94507046
109Onycholysis (HP:0001806)1.93976513
110Restlessness (HP:0000711)1.93940188
111Ketoacidosis (HP:0001993)1.93754213
112Hypoglycemic coma (HP:0001325)1.92689631
113Growth hormone excess (HP:0000845)1.89168336
114Xanthomatosis (HP:0000991)1.88953331
115Vertebral compression fractures (HP:0002953)1.88311442
116Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.87876410
117Polygenic inheritance (HP:0010982)1.87291828
118Hypoalphalipoproteinemia (HP:0003233)1.87065875
119Hypercortisolism (HP:0001578)1.86395129
120Cerebral aneurysm (HP:0004944)1.84447119
121Hypercholesterolemia (HP:0003124)1.84390676
122Conjunctival hamartoma (HP:0100780)1.80165205
123Abnormal tarsal ossification (HP:0008369)1.80162391
124Broad metatarsal (HP:0001783)1.79636610
125Seborrheic dermatitis (HP:0001051)1.79404563
126Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.79147345
127Vertebral hypoplasia (HP:0008417)1.79147345
128Limb hypertonia (HP:0002509)1.78802636
129Lethargy (HP:0001254)1.78705447
130Choanal stenosis (HP:0000452)1.78466719
131Abnormality of sulfur amino acid metabolism (HP:0004339)1.78097584
132Hyperammonemia (HP:0001987)1.77180475
133Ketosis (HP:0001946)1.77109256
134Precocious puberty (HP:0000826)1.76288708
135Hyperglycemia (HP:0003074)1.75370547
136Renal salt wasting (HP:0000127)1.75047877
137Pili torti (HP:0003777)1.74599237
138Glomerulopathy (HP:0100820)1.74542886
139Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73732128
140Testicular neoplasm (HP:0010788)1.72153988
141Visceral angiomatosis (HP:0100761)1.71971547
142Mildly elevated creatine phosphokinase (HP:0008180)1.71032932
143Shallow orbits (HP:0000586)1.70536255
144Plantar hyperkeratosis (HP:0007556)1.69615780
145Metaphyseal cupping (HP:0003021)1.68696871
146Subcapsular cataract (HP:0000523)1.68493614
147Abnormality of serum amino acid levels (HP:0003112)1.68133261
148Fragile skin (HP:0001030)1.67675821
149Aortic aneurysm (HP:0004942)1.66969721
150Aneurysm (HP:0002617)1.66770495
151Spastic tetraparesis (HP:0001285)1.66503030
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66263864
153Myokymia (HP:0002411)1.66210308
154Abnormality of the 1st metacarpal (HP:0010009)1.66178178
155Abnormality of the peritoneum (HP:0002585)1.66100578
156Turricephaly (HP:0000262)1.65920731
157Abnormality of the fingertips (HP:0001211)1.65623144
158Ectopia lentis (HP:0001083)1.64898353
159Spinal rigidity (HP:0003306)1.63793437
160Cone-rod dystrophy (HP:0000548)1.63784044
161Polar cataract (HP:0010696)1.62953233
162Dicarboxylic aciduria (HP:0003215)1.62939683
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62939683
164Mutism (HP:0002300)1.62533152
165Spinal cord compression (HP:0002176)1.62386476
166Periodontitis (HP:0000704)1.61026392
167Amyloidosis (HP:0011034)1.60815671
168Glomerulonephritis (HP:0000099)1.58447877
169Rapidly progressive (HP:0003678)1.58154249
170Joint hemorrhage (HP:0005261)1.58126451
171Congenital, generalized hypertrichosis (HP:0004540)1.58058031
172Microretrognathia (HP:0000308)1.57985004
173Long toe (HP:0010511)1.57832816
174Bilateral sensorineural hearing impairment (HP:0008619)1.57435176
175Tubulointerstitial fibrosis (HP:0005576)1.57182646
176Sudden death (HP:0001699)1.56759161
177Neonatal hypoglycemia (HP:0001998)1.56755474
178Hemangiomatosis (HP:0007461)1.56381472
179Abnormality of fatty-acid metabolism (HP:0004359)1.56324189
180Abnormality of carpal bone ossification (HP:0006257)1.55737387
181Short nail (HP:0001799)1.54991050
182Macroglossia (HP:0000158)1.52294505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.26270910
2MST1R3.84188922
3SIK13.36594070
4MAP3K63.35621703
5TIE12.97306106
6TGFBR22.64059408
7EPHA32.62988870
8CAMK12.08703057
9CAMK1D2.07540091
10MAPK42.05043352
11ERBB413.9666213
12TRIB31.93027537
13ABL21.86444433
14PKN21.83626740
15PRKAA11.83417964
16PIM21.73922311
17LRRK21.59783262
18ADRBK11.54343038
19MET1.54147911
20MAP3K91.51266899
21KSR21.47540522
22RIPK41.37210400
23CDK61.34703530
24MAP3K21.34429111
25CAMKK21.26778084
26GSK3A1.22628154
27MAP2K21.21987662
28MAPK151.19820179
29PRKACG1.15590814
30FER1.15338922
31TAOK21.15307106
32MAP2K11.14940329
33PIK3CG1.14605405
34NLK1.10851442
35CAMK1G1.10356637
36STK101.10319176
37IRAK11.09239771
38CLK11.07709764
39LATS21.06654919
40PTK60.99474521
41PRKG20.96279540
42CDK90.96139959
43LMTK20.94645020
44MTOR0.92129955
45RIPK10.89257579
46MAPK120.86930701
47FRK0.85006142
48ERN10.83184132
49FYN0.82396021
50NUAK10.82209105
51GRK10.80865215
52MOS0.79582709
53PAK30.79465065
54PRKCI0.78369093
55MAP2K30.77154266
56IRAK30.74487533
57PRPF4B0.73197534
58IKBKB0.72748831
59STK390.72115991
60NEK10.71468143
61NME10.71427106
62TAOK10.71365045
63PAK20.70862696
64JAK30.70570910
65TESK10.67544713
66FGFR40.66859763
67GRK50.64806620
68BCKDK0.63223670
69DDR20.62607056
70PDGFRB0.62470374
71NME20.61758428
72MAPK30.61401109
73WNK40.59957418
74ICK0.58857176
75BMPR20.56068120
76PAK40.55826521
77MAPK70.55683416
78ROCK20.55352178
79PDK40.54265250
80PDK30.54265250
81BMX0.53890537
82WNK10.53113150
83MAP3K80.52763112
84MAPK10.50482596
85MYLK0.49681432
86PRKACB0.49667704
87SRC0.49452515
88MAPKAPK30.49438478
89FLT30.48555098
90EEF2K0.48427762
91CDK40.47868355
92PTK20.47168746
93RPS6KB20.45131199
94ERBB20.44431940
95EPHB10.43655246
96JAK10.42687252
97MAP3K100.40883183
98PDPK10.39204612
99RET0.39180929
100MAP3K30.39035496
101ZAP700.38908925
102CHUK0.38882854
103PIM10.37708961
104RPS6KA50.36589468
105IGF1R0.36497195
106MAP2K40.36157061
107INSR0.35229672
108PRKG10.35152798
109MAP3K10.34028461
110RPS6KA20.33714102
111STK30.33412614
112FES0.33306791
113MATK0.32898736
114MAP3K50.30571325
115ROCK10.30241645
116GRK60.30113529
117CAMKK10.29930252
118ARAF0.29390279
119TYRO30.29146305
120CSK0.28904605
121LIMK10.28563220
122CDK190.28035519
123MELK0.27888870
124PDK10.27745973
125CAMK2B0.27568050
126RPS6KL10.26926276
127RPS6KC10.26926276
128DMPK0.26568498
129PDK20.25856296
130ALK0.25553774
131MAP3K110.24753772
132MINK10.24081383
133PDGFRA0.22820635
134NTRK10.22167914
135TTN0.21933093
136CAMK2D0.21662477
137EGFR0.21270263
138MAP3K130.20183192
139PRKD10.19434358
140FGR0.18835180
141CAMK2G0.18384899
142KSR10.17871982
143KDR0.16311368
144PRKCQ0.15672802
145EPHB20.14796895
146SCYL20.13217867
147CDK50.11953840
148ILK0.11010573
149PRKAA20.10930847
150PAK10.10800939
151DAPK30.10685953
152PHKG20.10627330
153PHKG10.10627330
154PAK60.10545837
155MAP3K70.10322861
156JAK20.09990094
157RPS6KA10.09462789
158RAF10.09169368
159TBK10.09074186

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.37897039
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.52999362
3Sulfur metabolism_Homo sapiens_hsa009205.05812884
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049235.04052880
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.62815446
6Gastric acid secretion_Homo sapiens_hsa049714.52148159
7Protein digestion and absorption_Homo sapiens_hsa049744.44810437
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.43249524
9Chemical carcinogenesis_Homo sapiens_hsa052043.90549076
10Glutathione metabolism_Homo sapiens_hsa004803.63574608
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.20629611
12Collecting duct acid secretion_Homo sapiens_hsa049663.00423848
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12457794
14Adipocytokine signaling pathway_Homo sapiens_hsa049202.00015215
15Fat digestion and absorption_Homo sapiens_hsa049751.87813183
16Mineral absorption_Homo sapiens_hsa049781.53929534
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49529680
18Nitrogen metabolism_Homo sapiens_hsa009101.47131921
19AMPK signaling pathway_Homo sapiens_hsa041521.40351997
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33173218
21Vitamin digestion and absorption_Homo sapiens_hsa049771.28649428
22Linoleic acid metabolism_Homo sapiens_hsa005911.23662400
23Fatty acid degradation_Homo sapiens_hsa000711.22658698
24Insulin signaling pathway_Homo sapiens_hsa049101.20569343
25Pancreatic secretion_Homo sapiens_hsa049721.17550874
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16480705
27Retinol metabolism_Homo sapiens_hsa008301.15506583
28Sulfur relay system_Homo sapiens_hsa041221.15159518
29Ether lipid metabolism_Homo sapiens_hsa005651.12942626
30Insulin resistance_Homo sapiens_hsa049311.05308527
31Thyroid hormone synthesis_Homo sapiens_hsa049181.02137004
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00621521
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96231621
34Pyruvate metabolism_Homo sapiens_hsa006200.95613035
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94800928
36Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90464366
37Propanoate metabolism_Homo sapiens_hsa006400.86697062
38Malaria_Homo sapiens_hsa051440.86548006
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.85569309
40Bile secretion_Homo sapiens_hsa049760.81842592
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80989849
42Ovarian steroidogenesis_Homo sapiens_hsa049130.80421529
43Butanoate metabolism_Homo sapiens_hsa006500.76798465
44Glycerolipid metabolism_Homo sapiens_hsa005610.74718370
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73796174
46Carbon metabolism_Homo sapiens_hsa012000.73343336
47Phenylalanine metabolism_Homo sapiens_hsa003600.72926281
48Histidine metabolism_Homo sapiens_hsa003400.72081053
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67207036
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65546336
51Tight junction_Homo sapiens_hsa045300.63890789
52Complement and coagulation cascades_Homo sapiens_hsa046100.63729862
53beta-Alanine metabolism_Homo sapiens_hsa004100.63551889
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62309790
55Type II diabetes mellitus_Homo sapiens_hsa049300.60807413
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.60644009
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60635371
58Fatty acid metabolism_Homo sapiens_hsa012120.60600125
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60138235
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59736875
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58216088
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55930299
63TNF signaling pathway_Homo sapiens_hsa046680.55827022
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55700260
65Acute myeloid leukemia_Homo sapiens_hsa052210.55696614
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54670873
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54255484
68Oxidative phosphorylation_Homo sapiens_hsa001900.53981232
69Thyroid cancer_Homo sapiens_hsa052160.53838709
70PPAR signaling pathway_Homo sapiens_hsa033200.53451140
71Dorso-ventral axis formation_Homo sapiens_hsa043200.52293454
72Arginine biosynthesis_Homo sapiens_hsa002200.51760126
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48559130
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46572640
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44913419
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43534340
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.43460712
78Pentose phosphate pathway_Homo sapiens_hsa000300.41927588
79Fructose and mannose metabolism_Homo sapiens_hsa000510.39846039
80Lysosome_Homo sapiens_hsa041420.39002339
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.38858413
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.38523628
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.37538631
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.37032839
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36470994
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.34859574
87Folate biosynthesis_Homo sapiens_hsa007900.31560347
88Tryptophan metabolism_Homo sapiens_hsa003800.30689555
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30110231
90Glucagon signaling pathway_Homo sapiens_hsa049220.29947033
91Adherens junction_Homo sapiens_hsa045200.29740029
92Prolactin signaling pathway_Homo sapiens_hsa049170.29688686
93One carbon pool by folate_Homo sapiens_hsa006700.29089339
94Tyrosine metabolism_Homo sapiens_hsa003500.27416443
95Lysine degradation_Homo sapiens_hsa003100.27158892
96Salivary secretion_Homo sapiens_hsa049700.25727189
97Bladder cancer_Homo sapiens_hsa052190.25434795
98Salmonella infection_Homo sapiens_hsa051320.25270028
99Arachidonic acid metabolism_Homo sapiens_hsa005900.25146671
100Vibrio cholerae infection_Homo sapiens_hsa051100.24978454
101Hepatitis C_Homo sapiens_hsa051600.24360057
102Dilated cardiomyopathy_Homo sapiens_hsa054140.23792809
103Osteoclast differentiation_Homo sapiens_hsa043800.23668538
104Shigellosis_Homo sapiens_hsa051310.23047542
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22610600
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21918649
107Proteoglycans in cancer_Homo sapiens_hsa052050.21575916
108FoxO signaling pathway_Homo sapiens_hsa040680.20117146
109Cardiac muscle contraction_Homo sapiens_hsa042600.19986657
110Vitamin B6 metabolism_Homo sapiens_hsa007500.18595057
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18492210
112ABC transporters_Homo sapiens_hsa020100.17967477
113Starch and sucrose metabolism_Homo sapiens_hsa005000.16765855
114Prion diseases_Homo sapiens_hsa050200.16246066
115Galactose metabolism_Homo sapiens_hsa000520.15684511
116Biosynthesis of amino acids_Homo sapiens_hsa012300.14877131
117Fatty acid elongation_Homo sapiens_hsa000620.14551015
118Peroxisome_Homo sapiens_hsa041460.14508527
119Estrogen signaling pathway_Homo sapiens_hsa049150.14424083
120Staphylococcus aureus infection_Homo sapiens_hsa051500.14330690
121Alzheimers disease_Homo sapiens_hsa050100.14047628
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.13941212
123Pertussis_Homo sapiens_hsa051330.12780076
124HIF-1 signaling pathway_Homo sapiens_hsa040660.12607300
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12444599
126GnRH signaling pathway_Homo sapiens_hsa049120.12339845
127Long-term potentiation_Homo sapiens_hsa047200.12210286
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11931136
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.11574899
130Focal adhesion_Homo sapiens_hsa045100.11548439
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11350593
132VEGF signaling pathway_Homo sapiens_hsa043700.10690109
133cAMP signaling pathway_Homo sapiens_hsa040240.10686056
134Insulin secretion_Homo sapiens_hsa049110.10431093
135Notch signaling pathway_Homo sapiens_hsa043300.08746369
136Renin secretion_Homo sapiens_hsa049240.08617294
137Metabolic pathways_Homo sapiens_hsa011000.08566940
138Chronic myeloid leukemia_Homo sapiens_hsa052200.08153291
139Cocaine addiction_Homo sapiens_hsa050300.07959081
140ECM-receptor interaction_Homo sapiens_hsa045120.07370991
141HTLV-I infection_Homo sapiens_hsa051660.06338092
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04791903
143Rap1 signaling pathway_Homo sapiens_hsa040150.04737454
144Circadian rhythm_Homo sapiens_hsa047100.03928637
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01809912
146Arginine and proline metabolism_Homo sapiens_hsa003300.01280106
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.00511825
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.00415351
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0029611

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