GKN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fibril organization (GO:0097435)8.87202233
2glutathione derivative metabolic process (GO:1901685)8.40832084
3glutathione derivative biosynthetic process (GO:1901687)8.40832084
4O-glycan processing (GO:0016266)8.19408724
5digestive system process (GO:0022600)7.87778970
6response to iron ion (GO:0010039)7.64164307
7protein autoprocessing (GO:0016540)7.62132314
8sulfation (GO:0051923)7.53596772
9cellular response to nitric oxide (GO:0071732)7.36640013
10regulation of proton transport (GO:0010155)7.31499515
11cellular response to zinc ion (GO:0071294)6.72846077
12bundle of His cell to Purkinje myocyte communication (GO:0086069)6.70887946
13cellular response to reactive nitrogen species (GO:1902170)6.32174221
14negative regulation of complement activation (GO:0045916)6.18616820
15glandular epithelial cell differentiation (GO:0002067)6.14237609
16peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)6.13623926
17purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.13522506
183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.13522506
19kidney morphogenesis (GO:0060993)6.10434103
20negative regulation of digestive system process (GO:0060457)5.99949674
21protein O-linked glycosylation (GO:0006493)5.81491740
22regulation of vasculogenesis (GO:2001212)5.51930277
23production of molecular mediator of immune response (GO:0002440)5.50504455
24negative regulation of protein activation cascade (GO:2000258)5.45688033
25positive regulation of vasculogenesis (GO:2001214)5.33647737
26response to nitric oxide (GO:0071731)5.20986959
27cellular response to cadmium ion (GO:0071276)5.14242310
28regulation of integrin-mediated signaling pathway (GO:2001044)5.13388053
29negative regulation of humoral immune response (GO:0002921)4.99993075
30regulation of phospholipase A2 activity (GO:0032429)4.93503334
31fucose catabolic process (GO:0019317)4.79518552
32L-fucose metabolic process (GO:0042354)4.79518552
33L-fucose catabolic process (GO:0042355)4.79518552
34intestinal absorption (GO:0050892)4.73047967
35thyroid hormone metabolic process (GO:0042403)4.65794445
36positive regulation of endothelial cell differentiation (GO:0045603)4.64533846
37phosphatidylserine acyl-chain remodeling (GO:0036150)4.53936613
38respiratory gaseous exchange (GO:0007585)4.49909353
39peptidyl-proline hydroxylation (GO:0019511)4.49172573
40regulation of sequestering of triglyceride (GO:0010889)4.45961080
41sulfur amino acid catabolic process (GO:0000098)4.43638328
42glutathione metabolic process (GO:0006749)4.37233896
43thyroid hormone generation (GO:0006590)4.34184832
44phospholipid scrambling (GO:0017121)4.26682537
45macrophage chemotaxis (GO:0048246)4.07907100
46regulation of endothelial cell differentiation (GO:0045601)3.97374274
47protein retention in ER lumen (GO:0006621)3.95984142
48regulation of pH (GO:0006885)3.94607289
49negative regulation of transcription by competitive promoter binding (GO:0010944)3.91122402
50ventricular cardiac muscle cell action potential (GO:0086005)3.90623845
51phosphatidylserine metabolic process (GO:0006658)3.88662087
52polyketide metabolic process (GO:0030638)3.87466360
53doxorubicin metabolic process (GO:0044598)3.87466360
54daunorubicin metabolic process (GO:0044597)3.87466360
55embryonic foregut morphogenesis (GO:0048617)3.85949593
56xenobiotic metabolic process (GO:0006805)3.83584801
57renal absorption (GO:0070293)3.83466090
58nitric oxide biosynthetic process (GO:0006809)3.78656785
59regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.75703395
60atrioventricular valve morphogenesis (GO:0003181)3.75626457
61endocrine hormone secretion (GO:0060986)3.73520191
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73407427
63lung secretory cell differentiation (GO:0061140)3.71265552
64protein hydroxylation (GO:0018126)3.66461881
65leukotriene metabolic process (GO:0006691)3.65183774
66low-density lipoprotein particle clearance (GO:0034383)3.62350898
67cellular response to gonadotropin stimulus (GO:0071371)3.61761517
68positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.61145234
69response to hyperoxia (GO:0055093)3.57867776
70response to increased oxygen levels (GO:0036296)3.57867776
71pH reduction (GO:0045851)3.52686507
72regulation of cardioblast differentiation (GO:0051890)3.50635328
73diacylglycerol metabolic process (GO:0046339)3.47170405
74negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.46992870
75receptor recycling (GO:0001881)3.43948006
76cellular response to arsenic-containing substance (GO:0071243)3.42658037
77induction of positive chemotaxis (GO:0050930)3.42126944
78leukotriene biosynthetic process (GO:0019370)3.40295913
79positive regulation of p38MAPK cascade (GO:1900745)3.39906155
80phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.39860709
81aminoglycoside antibiotic metabolic process (GO:0030647)3.38691528
82positive regulation of lipid storage (GO:0010884)3.36611894
83cellular response to thyroid hormone stimulus (GO:0097067)3.29888205
84one-carbon compound transport (GO:0019755)3.27624347
85retinal metabolic process (GO:0042574)3.25717940
86phosphatidylinositol acyl-chain remodeling (GO:0036149)3.24842584
87arachidonic acid secretion (GO:0050482)3.24680036
88intestinal epithelial cell development (GO:0060576)3.22327545
89cytoskeletal anchoring at plasma membrane (GO:0007016)3.22204812
90cyclooxygenase pathway (GO:0019371)3.20175596
91triglyceride catabolic process (GO:0019433)3.18654135
92complement activation (GO:0006956)3.16483463
93alditol phosphate metabolic process (GO:0052646)3.16064169
94cellular response to oxygen radical (GO:0071450)3.15926616
95removal of superoxide radicals (GO:0019430)3.15926616
96cellular response to superoxide (GO:0071451)3.15926616
97progesterone metabolic process (GO:0042448)3.15746605
98ethanol oxidation (GO:0006069)3.15237823
99phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.14961052
100regulation of heart rate by cardiac conduction (GO:0086091)3.11492077
101L-serine transport (GO:0015825)3.09574354
102peptide cross-linking (GO:0018149)3.09040933
103acrosome reaction (GO:0007340)3.07774981
104regulation of complement activation (GO:0030449)3.06727245
105endothelium development (GO:0003158)3.06572962
106polyol transport (GO:0015791)3.02590961
107peptide catabolic process (GO:0043171)3.00231452
108neutrophil mediated immunity (GO:0002446)2.98257810
109response to vitamin A (GO:0033189)2.98147644
110columnar/cuboidal epithelial cell differentiation (GO:0002065)2.97319242
111complement activation, classical pathway (GO:0006958)2.96280302
112acid secretion (GO:0046717)2.95754573
113membrane raft organization (GO:0031579)2.95414802
114myelin maintenance (GO:0043217)2.95005861
115negative regulation of interleukin-2 production (GO:0032703)2.93428492
116lung vasculature development (GO:0060426)2.93358096
1174-hydroxyproline metabolic process (GO:0019471)2.91566539
118sodium ion export (GO:0071436)2.91467419
119glomerular filtration (GO:0003094)2.91080053
120ribonucleoside bisphosphate metabolic process (GO:0033875)2.86900608
121nucleoside bisphosphate metabolic process (GO:0033865)2.86900608
122purine nucleoside bisphosphate metabolic process (GO:0034032)2.86900608
123response to interleukin-6 (GO:0070741)2.86657938
124renal filtration (GO:0097205)2.86235403
125fatty acid derivative transport (GO:1901571)2.85149587
126icosanoid transport (GO:0071715)2.85149587
127regulation of transforming growth factor beta1 production (GO:0032908)2.84675592
128cell communication involved in cardiac conduction (GO:0086065)2.81774011
129desmosome organization (GO:0002934)2.80658017
130regulation of skeletal muscle contraction (GO:0014819)2.79604031
131regulation of macrophage activation (GO:0043030)2.79172047
132regulation of protein activation cascade (GO:2000257)2.78660003
133response to superoxide (GO:0000303)2.78458838
134regulation of metalloenzyme activity (GO:0048552)2.77930772
135hepatocyte apoptotic process (GO:0097284)2.77855691
136cGMP biosynthetic process (GO:0006182)2.77531193
137nucleotide-sugar biosynthetic process (GO:0009226)2.77046233
138fucose metabolic process (GO:0006004)2.76225846
139regulation of p38MAPK cascade (GO:1900744)2.75424413
140cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.74143651
141growth hormone secretion (GO:0030252)2.73639267
142lipid storage (GO:0019915)2.72157108
143cardiac conduction (GO:0061337)2.72066561
144cobalamin metabolic process (GO:0009235)2.71653910
145ethanol metabolic process (GO:0006067)2.71587157
146neutral lipid catabolic process (GO:0046461)2.70428051
147acylglycerol catabolic process (GO:0046464)2.70428051
148hexose catabolic process (GO:0019320)2.70284221
149intestinal cholesterol absorption (GO:0030299)2.69707853
150epithelial cell-cell adhesion (GO:0090136)2.67807593
151response to gonadotropin (GO:0034698)2.67468201
152endocardial cushion development (GO:0003197)2.67056036
153galactose catabolic process (GO:0019388)2.66352024
154lymphangiogenesis (GO:0001946)2.66013152
155flavonoid metabolic process (GO:0009812)2.65915245
156vitamin transport (GO:0051180)2.65494259
157serine transport (GO:0032329)2.64896262
158icosanoid secretion (GO:0032309)2.63316374
159protein activation cascade (GO:0072376)2.63012143
160regulation of glomerular filtration (GO:0003093)2.61537985
161iron ion import (GO:0097286)2.57966483
162cellular response to antibiotic (GO:0071236)2.56323760
163norepinephrine metabolic process (GO:0042415)2.53637020
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52310334
165heart trabecula formation (GO:0060347)2.52132007
166regulation of cholesterol storage (GO:0010885)2.50875325
167vascular endothelial growth factor signaling pathway (GO:0038084)2.49138153
168response to thyroid hormone (GO:0097066)2.48531721
169regulation of digestive system process (GO:0044058)2.48065527
170regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47914187
171positive regulation of receptor recycling (GO:0001921)2.45921744
172transcytosis (GO:0045056)2.45309883
173regulation of lipid storage (GO:0010883)2.45114290
174toxin metabolic process (GO:0009404)2.44952810
175extracellular matrix assembly (GO:0085029)2.40085019
176positive regulation of endothelial cell apoptotic process (GO:2000353)2.37351967
177regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.37238027
178prostaglandin metabolic process (GO:0006693)2.35821184
179prostanoid metabolic process (GO:0006692)2.35821184
180calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35060238
181cellular hyperosmotic response (GO:0071474)2.34496794
182regulation of hippo signaling (GO:0035330)2.33108893
183hyperosmotic salinity response (GO:0042538)2.32832191
184fibroblast migration (GO:0010761)2.31286943
185adhesion of symbiont to host cell (GO:0044650)2.31091869
186maintenance of gastrointestinal epithelium (GO:0030277)17.9464786
187surfactant homeostasis (GO:0043129)15.8267097
188epithelial structure maintenance (GO:0010669)13.5877723
189chemical homeostasis within a tissue (GO:0048875)12.5205775
190digestion (GO:0007586)10.8508402
191extracellular fibril organization (GO:0043206)10.3015341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human7.20076115
2SOX2_27498859_Chip-Seq_STOMACH_Mouse6.03039365
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.19462807
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.89597719
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.86259868
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.65400059
7GATA4_25053715_ChIP-Seq_YYC3_Human3.08499089
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.98175378
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83458561
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.79202715
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60694255
12SOX2_20726797_ChIP-Seq_SW620_Human2.54351069
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.53809991
14PPAR_26484153_Chip-Seq_NCI-H1993_Human2.39949140
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39595183
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.36155698
17GATA6_25053715_ChIP-Seq_YYC3_Human2.32885865
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.31702222
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.31296189
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.23157619
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12392230
22SRY_22984422_ChIP-ChIP_TESTIS_Rat2.07801602
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95506383
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95090771
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90540174
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.90274389
27STAT1_20625510_ChIP-Seq_HELA_Human1.87414944
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86166913
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.83554513
30IGF1R_20145208_ChIP-Seq_DFB_Human1.83532939
31KLF5_25053715_ChIP-Seq_YYC3_Human1.83269505
32LXR_22292898_ChIP-Seq_THP-1_Human1.82434850
33AHR_22903824_ChIP-Seq_MCF-7_Human1.80183779
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79518987
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77553216
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74070063
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73930527
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.71596184
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.69455233
40NFIB_24661679_ChIP-Seq_LUNG_Mouse1.65634243
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.65339246
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64015916
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.59548425
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59466523
45RACK7_27058665_Chip-Seq_MCF-7_Human1.59200208
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.58090830
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51128853
48EGR1_19032775_ChIP-ChIP_M12_Human1.50667784
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.49944010
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.49944010
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49699499
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47878380
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47252286
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.45085449
55VDR_22108803_ChIP-Seq_LS180_Human1.44011615
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41786567
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.41707407
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41291492
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38737981
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35527517
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34584328
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34307192
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33821758
64AR_21572438_ChIP-Seq_LNCaP_Human1.30243485
65ZNF263_19887448_ChIP-Seq_K562_Human1.29139933
66* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25969336
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25851972
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25697197
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23719625
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.21726289
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20938195
72ATF3_27146783_Chip-Seq_COLON_Human1.18271209
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.16554206
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.16124767
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14827516
76CLOCK_20551151_ChIP-Seq_293T_Human1.14703447
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14628943
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14023193
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13996082
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13150174
81KDM2B_26808549_Chip-Seq_K562_Human1.12499891
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09792553
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.09255288
84RXR_22108803_ChIP-Seq_LS180_Human1.08089846
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.06956529
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06470216
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06317507
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03979467
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01134718
90SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99601837
91ZNF274_21170338_ChIP-Seq_K562_Hela0.99562968
92* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99251472
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97768431
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97543260
95GATA2_21666600_ChIP-Seq_HMVEC_Human0.96394745
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93552364
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92228410
98CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91653722
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91420741
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.91006395
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89530553
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89248164
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.89174439
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88314854
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88121848
106* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87287300
107BCAT_22108803_ChIP-Seq_LS180_Human0.87246703
108CJUN_26792858_Chip-Seq_BT549_Human0.87113276
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86659245
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86659245
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86197022
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.85088008
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.85088008
114IRF8_27001747_Chip-Seq_BMDM_Mouse0.84921395
115P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83770963
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83511715
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82944505
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82768615
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.81820641
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81542749
121VDR_24787735_ChIP-Seq_THP-1_Human0.81429032
122CREB1_26743006_Chip-Seq_LNCaP_Human0.80877225
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.80774856
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.80444747
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79722177
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79579483
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79395666
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78484342
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78059686
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77805166
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77805166
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77805166
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77488920
134P53_21459846_ChIP-Seq_SAOS-2_Human0.77395038
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77174484
136CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75929220
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75553210
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75135857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog7.65580797
2MP0001873_stomach_inflammation5.96020996
3MP0001958_emphysema5.59772907
4MP0001664_abnormal_digestion5.13776601
5MP0000470_abnormal_stomach_morphology3.88651008
6MP0008995_early_reproductive_senescence3.68441334
7MP0003806_abnormal_nucleotide_metabolis3.55034553
8MP0010368_abnormal_lymphatic_system3.34096352
9MP0005670_abnormal_white_adipose2.85724823
10MP0001879_abnormal_lymphatic_vessel2.78612716
11MP0005666_abnormal_adipose_tissue2.61465347
12MP0005388_respiratory_system_phenotype2.43397530
13MP0002133_abnormal_respiratory_system2.43397530
14MP0001542_abnormal_bone_strength2.38363833
15MP0003950_abnormal_plasma_membrane2.28036642
16MP0002295_abnormal_pulmonary_circulatio2.11587698
17MP0001663_abnormal_digestive_system2.09179548
18MP0005164_abnormal_response_to2.00932306
19MP0008004_abnormal_stomach_pH17.4109910
20MP0002971_abnormal_brown_adipose1.92062262
21MP0003091_abnormal_cell_migration1.85957646
22MP0005381_digestive/alimentary_phenotyp1.85391630
23MP0004883_abnormal_blood_vessel1.85255005
24MP0006138_congestive_heart_failure1.81822108
25MP0005375_adipose_tissue_phenotype1.77120940
26MP0001666_abnormal_nutrient_absorption1.73637663
27MP0005165_increased_susceptibility_to1.72387624
28MP0010234_abnormal_vibrissa_follicle1.71781427
29MP0001177_atelectasis1.54632216
30MP0001851_eye_inflammation1.51749049
31MP0005083_abnormal_biliary_tract1.43930817
32MP0005595_abnormal_vascular_smooth1.40769149
33MP0003828_pulmonary_edema1.36381374
34MP0004264_abnormal_extraembryonic_tissu1.31058250
35MP0000249_abnormal_blood_vessel1.28468045
36MP0000477_abnormal_intestine_morphology1.27286916
37MP0001986_abnormal_taste_sensitivity1.22095572
38MP0003303_peritoneal_inflammation1.19576545
39MP0006054_spinal_hemorrhage1.18302999
40MP0003279_aneurysm1.13547313
41MP0002405_respiratory_system_inflammati1.12758988
42MP0001175_abnormal_lung_morphology1.10829786
43MP0003283_abnormal_digestive_organ1.10155037
44MP0001440_abnormal_grooming_behavior1.09705892
45MP0003186_abnormal_redox_activity1.08834638
46MP0002998_abnormal_bone_remodeling1.05152672
47MP0005334_abnormal_fat_pad1.03005316
48MP0005535_abnormal_body_temperature1.02192422
49MP0005647_abnormal_sex_gland1.01097932
50MP0003705_abnormal_hypodermis_morpholog1.01037750
51MP0005085_abnormal_gallbladder_physiolo1.01027044
52MP0003786_premature_aging1.00169130
53MP0000462_abnormal_digestive_system0.99422520
54MP0001661_extended_life_span0.97473009
55MP0009384_cardiac_valve_regurgitation0.94559791
56MP0002909_abnormal_adrenal_gland0.94296984
57MP0009840_abnormal_foam_cell0.93486750
58MP0005503_abnormal_tendon_morphology0.90911070
59MP0009115_abnormal_fat_cell0.90039175
60MP0000003_abnormal_adipose_tissue0.89852645
61MP0005023_abnormal_wound_healing0.88838191
62MP0001756_abnormal_urination0.86965755
63MP0005448_abnormal_energy_balance0.81799009
64MP0005397_hematopoietic_system_phenotyp0.78151595
65MP0001545_abnormal_hematopoietic_system0.78151595
66MP0000767_abnormal_smooth_muscle0.77237474
67MP0005365_abnormal_bile_salt0.76717177
68MP0000537_abnormal_urethra_morphology0.76274652
69MP0003948_abnormal_gas_homeostasis0.75903341
70MP0002136_abnormal_kidney_physiology0.75889703
71MP0000490_abnormal_crypts_of0.75776653
72MP0001501_abnormal_sleep_pattern0.75743387
73MP0003868_abnormal_feces_composition0.75311051
74MP0002332_abnormal_exercise_endurance0.75218759
75MP0003448_altered_tumor_morphology0.74608278
76MP0004858_abnormal_nervous_system0.72373722
77MP0005266_abnormal_metabolism0.71661289
78MP0008875_abnormal_xenobiotic_pharmacok0.71418520
79MP0005387_immune_system_phenotype0.71006337
80MP0001790_abnormal_immune_system0.71006337
81MP0008775_abnormal_heart_ventricle0.68974863
82MP0003115_abnormal_respiratory_system0.68812367
83MP0002128_abnormal_blood_circulation0.68695878
84MP0003690_abnormal_glial_cell0.67699379
85MP0002877_abnormal_melanocyte_morpholog0.67344493
86MP0005058_abnormal_lysosome_morphology0.66620629
87MP0003959_abnormal_lean_body0.65522556
88MP0010329_abnormal_lipoprotein_level0.64074997
89MP0002933_joint_inflammation0.64045805
90MP0005636_abnormal_mineral_homeostasis0.63626564
91MP0001614_abnormal_blood_vessel0.62642200
92MP0004185_abnormal_adipocyte_glucose0.62222691
93MP0001853_heart_inflammation0.62211075
94MP0002234_abnormal_pharynx_morphology0.62171559
95MP0002419_abnormal_innate_immunity0.62159015
96MP0002138_abnormal_hepatobiliary_system0.61498732
97MP0004484_altered_response_of0.61015798
98MP0004084_abnormal_cardiac_muscle0.60885510
99MP0003329_amyloid_beta_deposits0.59815213
100MP0000467_abnormal_esophagus_morphology0.57267796
101MP0002796_impaired_skin_barrier0.54619300
102MP0003075_altered_response_to0.54383351
103MP0010155_abnormal_intestine_physiology0.54156823
104MP0003119_abnormal_digestive_system0.50315701
105MP0002139_abnormal_hepatobiliary_system0.49115727
106MP0003566_abnormal_cell_adhesion0.48527222
107MP0004947_skin_inflammation0.48361687
108MP0001243_abnormal_dermal_layer0.47166201
109MP0001849_ear_inflammation0.43795367
110MP0004272_abnormal_basement_membrane0.42172633
111MP0002118_abnormal_lipid_homeostasis0.39772292
112MP0002019_abnormal_tumor_incidence0.37911030
113MP0003866_abnormal_defecation0.37903630
114MP0005166_decreased_susceptibility_to0.37276282
115MP0002009_preneoplasia0.36546821
116MP0003953_abnormal_hormone_level0.36277298
117MP0001216_abnormal_epidermal_layer0.35996055
118MP0003191_abnormal_cellular_cholesterol0.35182485
119MP0002060_abnormal_skin_morphology0.34919134
120MP0002078_abnormal_glucose_homeostasis0.33957045
121MP0002693_abnormal_pancreas_physiology0.33533278
122MP0010678_abnormal_skin_adnexa0.33007225
123MP0000604_amyloidosis0.32800634
124MP0003453_abnormal_keratinocyte_physiol0.32407633
125MP0008873_increased_physiological_sensi0.32240684
126MP0005584_abnormal_enzyme/coenzyme_acti0.31830403
127MP0005275_abnormal_skin_tensile0.31717532
128MP0009780_abnormal_chondrocyte_physiolo0.29594993
129MP0010352_gastrointestinal_tract_polyps0.28787822
130MP0001845_abnormal_inflammatory_respons0.28707709
131MP0000609_abnormal_liver_physiology0.28020858
132MP0003638_abnormal_response/metabolism_0.26635992
133MP0000598_abnormal_liver_morphology0.26382882
134MP0000367_abnormal_coat/_hair0.26042470
135MP0005501_abnormal_skin_physiology0.25548090
136MP0008961_abnormal_basal_metabolism0.25467532
137MP0005376_homeostasis/metabolism_phenot0.24829275
138MP0005319_abnormal_enzyme/_coenzyme0.24771830
139MP0002970_abnormal_white_adipose0.24478167
140MP0003724_increased_susceptibility_to0.24424454
141MP0005408_hypopigmentation0.24181147
142MP0003252_abnormal_bile_duct0.23957384
143MP0009642_abnormal_blood_homeostasis0.23788272
144MP0005310_abnormal_salivary_gland0.21601416
145MP0005464_abnormal_platelet_physiology0.21070700
146MP0010771_integument_phenotype0.20531994
147MP0005332_abnormal_amino_acid0.19959369
148MP0009931_abnormal_skin_appearance0.19100512
149MP0004130_abnormal_muscle_cell0.18715029
150MP0009643_abnormal_urine_homeostasis0.18210901
151MP0000013_abnormal_adipose_tissue0.17976747
152MP0009053_abnormal_anal_canal0.17753346
153MP0001191_abnormal_skin_condition0.17507153
154MP0004043_abnormal_pH_regulation0.16404642
155MP0005084_abnormal_gallbladder_morpholo0.16293692
156MP0000343_altered_response_to0.15677902
157MP0005167_abnormal_blood-brain_barrier0.15574219
158MP0005360_urolithiasis0.15395557
159MP0004019_abnormal_vitamin_homeostasis0.15161659
160MP0008438_abnormal_cutaneous_collagen0.14749486
161MP0005623_abnormal_meninges_morphology0.14442183
162MP0005076_abnormal_cell_differentiation0.14413307
163MP0005367_renal/urinary_system_phenotyp0.14091144
164MP0000516_abnormal_urinary_system0.14091144

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)9.41029004
2Abnormality of cells of the erythroid lineage (HP:0012130)9.13762777
3Tachypnea (HP:0002789)6.67848192
4Systemic lupus erythematosus (HP:0002725)5.62187921
5Respiratory distress (HP:0002098)5.37943948
6Megaloblastic anemia (HP:0001889)4.78979147
7Complement deficiency (HP:0004431)4.47371682
8Abnormality of the vitamin B12 metabolism (HP:0004341)4.36660339
9Glomerulonephritis (HP:0000099)4.30528196
10Abnormality of the fingertips (HP:0001211)4.28100873
11Abnormality of complement system (HP:0005339)4.16274446
12Palpitations (HP:0001962)4.12641880
13Abnormality of vitamin B metabolism (HP:0004340)4.11061645
14Acanthosis nigricans (HP:0000956)4.03246057
15Woolly hair (HP:0002224)3.99183645
16Goiter (HP:0000853)3.95280106
17Syncope (HP:0001279)3.94427561
18Gout (HP:0001997)3.88733546
19Abnormality of vitamin metabolism (HP:0100508)3.83953627
20Tubulointerstitial abnormality (HP:0001969)3.75431245
21Hyperactive renin-angiotensin system (HP:0000841)3.74701210
22Alveolar cell carcinoma (HP:0006519)3.61268968
23Intrahepatic cholestasis (HP:0001406)3.50919807
24Back pain (HP:0003418)3.45973695
25Pulmonary hypertension (HP:0002092)3.38021501
26Polycythemia (HP:0001901)3.35048141
27Neoplasm of the tracheobronchial system (HP:0100552)3.29192512
28Abnormality of purine metabolism (HP:0004352)3.19917523
29Nephritis (HP:0000123)3.07020566
30Ventricular fibrillation (HP:0001663)3.05902387
31Flat acetabular roof (HP:0003180)3.05743456
32Hypertriglyceridemia (HP:0002155)2.96482224
33Glomerulosclerosis (HP:0000096)2.91212941
34Frequent falls (HP:0002359)2.84136115
35Hyperkalemia (HP:0002153)2.84027449
36Arterial tortuosity (HP:0005116)2.78618572
37Hemiplegia (HP:0002301)2.77529507
38Vertebral arch anomaly (HP:0008438)2.76584200
39Azoospermia (HP:0000027)2.70302950
40Bone cyst (HP:0012062)2.69698912
41Ventricular arrhythmia (HP:0004308)2.69169926
42Segmental peripheral demyelination/remyelination (HP:0003481)2.68351635
43Eczematoid dermatitis (HP:0000976)2.67007220
44Osteolytic defects of the hand bones (HP:0009699)2.64156927
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.64156927
46Ventricular tachycardia (HP:0004756)2.61280993
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55322189
48Exertional dyspnea (HP:0002875)2.53640961
49Hematochezia (HP:0002573)2.52891354
50Micronodular cirrhosis (HP:0001413)2.52480426
51Hemorrhage of the eye (HP:0011885)2.51111172
52Insulin resistance (HP:0000855)2.47299569
53Long toe (HP:0010511)2.45632384
54Vascular tortuosity (HP:0004948)2.43544825
55Hypergammaglobulinemia (HP:0010702)2.42824824
56Increased purine levels (HP:0004368)2.41540525
57Hyperuricemia (HP:0002149)2.41540525
58Increased IgE level (HP:0003212)2.40469707
59Abnormality of the gastric mucosa (HP:0004295)2.38176890
60Abnormal cartilage morphology (HP:0002763)2.37741673
61Atrophic scars (HP:0001075)2.37256291
62Ulnar claw (HP:0001178)2.36151147
63Bilateral sensorineural hearing impairment (HP:0008619)2.34185370
64Myocardial infarction (HP:0001658)2.33677467
65Deep venous thrombosis (HP:0002625)2.32783490
66Vascular calcification (HP:0004934)2.28980517
67Agitation (HP:0000713)2.27192797
68Skin nodule (HP:0200036)2.24874977
69Aortic aneurysm (HP:0004942)2.24405299
70Decreased circulating renin level (HP:0003351)2.23941993
71Focal segmental glomerulosclerosis (HP:0000097)2.23385052
72Abdominal distention (HP:0003270)2.20236554
73Aortic dissection (HP:0002647)2.15850160
74Fragile nails (HP:0001808)2.15575250
75Chronic bronchitis (HP:0004469)2.15176181
76Epidermoid cyst (HP:0200040)2.15033025
77Abnormality of chloride homeostasis (HP:0011422)2.14663177
78Macrocytic anemia (HP:0001972)2.14353738
79Curly hair (HP:0002212)2.13134465
80Reduced subcutaneous adipose tissue (HP:0003758)2.12148147
81Abnormality of the periventricular white matter (HP:0002518)2.12135451
82Cardiovascular calcification (HP:0011915)2.11925010
83Steatorrhea (HP:0002570)2.11741252
84Esophageal varix (HP:0002040)2.11532522
85Broad metatarsal (HP:0001783)2.11483862
86Hyperpituitarism (HP:0010514)2.08063638
87Hypoglycemic coma (HP:0001325)2.06580972
88Axonal loss (HP:0003447)2.05095513
89Sudden cardiac death (HP:0001645)2.05022027
90Onycholysis (HP:0001806)2.04408586
91Metaphyseal dysplasia (HP:0100255)2.04001699
92Spontaneous hematomas (HP:0007420)2.03959060
93Glucose intolerance (HP:0000833)2.03222127
94Growth hormone excess (HP:0000845)2.01050548
95Interstitial pulmonary disease (HP:0006530)15.2533998
96Abnormal number of erythroid precursors (HP:0012131)10.1661696
97Neoplasm of the lung (HP:0100526)1.99674747
98Infantile muscular hypotonia (HP:0008947)1.99106071
99Milia (HP:0001056)1.98681322
100Malnutrition (HP:0004395)1.96632707
101Increased CSF protein (HP:0002922)1.95441806
102Short nail (HP:0001799)1.94014752
103Hypokalemic alkalosis (HP:0001949)1.93739762
104Abnormal hemoglobin (HP:0011902)1.92926076
105Abnormal tarsal ossification (HP:0008369)1.92261218
106Sensorimotor neuropathy (HP:0007141)1.91754783
107Increased variability in muscle fiber diameter (HP:0003557)1.91308541
108Seborrheic dermatitis (HP:0001051)1.89479607
109Achilles tendon contracture (HP:0001771)1.89423459
110Ketoacidosis (HP:0001993)1.89094681
111Abnormality of the Achilles tendon (HP:0005109)1.88875550
112Insulin-resistant diabetes mellitus (HP:0000831)1.88335124
113Cupped ribs (HP:0000887)1.88259200
114Progressive sensorineural hearing impairment (HP:0000408)1.87939730
115Polygenic inheritance (HP:0010982)1.87845380
116Conjugated hyperbilirubinemia (HP:0002908)1.85767736
117Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.85604681
118Vertebral hypoplasia (HP:0008417)1.85604681
119Pustule (HP:0200039)1.83512011
120Lethargy (HP:0001254)1.82832358
121Tubulointerstitial nephritis (HP:0001970)1.82315810
122Abnormality of nucleobase metabolism (HP:0010932)1.79774916
123Testicular neoplasm (HP:0010788)1.79271354
124Pulmonary artery stenosis (HP:0004415)1.78507325
125Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.77984371
126Spinal cord compression (HP:0002176)1.77743805
127Cerebral aneurysm (HP:0004944)1.77605911
128Pulmonary fibrosis (HP:0002206)1.77308204
129Renal salt wasting (HP:0000127)1.77209076
130Recurrent abscess formation (HP:0002722)1.75725780
131Ketosis (HP:0001946)1.75410512
132Difficulty running (HP:0009046)1.74911243
133Large hands (HP:0001176)1.74697133
134Visceral angiomatosis (HP:0100761)1.74210876
135Tubulointerstitial fibrosis (HP:0005576)1.73769268
136Hypotension (HP:0002615)1.73727714
137Resting tremor (HP:0002322)1.73715353
138Aneurysm (HP:0002617)1.73640287
139Xanthomatosis (HP:0000991)1.72445326
140Recurrent gram-negative bacterial infections (HP:0005420)1.71796196
141Hypoalphalipoproteinemia (HP:0003233)1.71609460
142Oligomenorrhea (HP:0000876)1.71254554
143Ankyloglossia (HP:0010296)1.70850554
144Abnormality of skeletal muscle fiber size (HP:0012084)1.70192137
145Conjunctival hamartoma (HP:0100780)1.70017816
146Hyperaldosteronism (HP:0000859)1.69635978
147Microretrognathia (HP:0000308)1.69521033
148Protrusio acetabuli (HP:0003179)1.69209240
149Difficulty walking (HP:0002355)1.68521819
150Urinary glycosaminoglycan excretion (HP:0003541)1.68355011
151Mucopolysacchariduria (HP:0008155)1.68355011
152Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67171955
153Abnormality of polysaccharide metabolism (HP:0011012)1.67171955
154Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67171955
155Restlessness (HP:0000711)1.66704659
156Abnormality of renin-angiotensin system (HP:0000847)1.66639774
157Atrioventricular block (HP:0001678)1.66274963
158Hyperammonemia (HP:0001987)1.66188414
159Neoplasm of the respiratory system (HP:0100606)1.65288051
160Abnormal spermatogenesis (HP:0008669)1.64837684
161Hyperglycemia (HP:0003074)1.64437509
162Abnormality of aromatic amino acid family metabolism (HP:0004338)1.64035828
163Wormian bones (HP:0002645)1.63909260
164Redundant skin (HP:0001582)1.63714790
165Portal hypertension (HP:0001409)1.63660409
166Hemangiomatosis (HP:0007461)1.63308118
167Abnormality of the intrinsic pathway (HP:0010989)1.63023773
168Abnormality of the 1st metacarpal (HP:0010009)1.61814141
169Abnormal pancreas size (HP:0012094)1.60789972
170Paresthesia (HP:0003401)1.60771073
171Striae distensae (HP:0001065)1.60724573
172Camptodactyly of toe (HP:0001836)1.60646394
173Plantar hyperkeratosis (HP:0007556)1.58737232
174Sudden death (HP:0001699)1.58274692
175Mildly elevated creatine phosphokinase (HP:0008180)1.57662316
176Fat malabsorption (HP:0002630)1.56235036
177Accelerated skeletal maturation (HP:0005616)1.55858328
178Hypoplastic left heart (HP:0004383)1.54909981
179Stridor (HP:0010307)1.54573527
180Turricephaly (HP:0000262)1.54513139
181Hydroureter (HP:0000072)1.52956394
182Abnormality of fatty-acid metabolism (HP:0004359)1.51182344
183Rapidly progressive (HP:0003678)1.50880001
184Congenital, generalized hypertrichosis (HP:0004540)1.50477340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.62943673
2MST1R4.27847844
3TGFBR23.03210572
4EPHA32.69932379
5TRIB32.35346159
6PKN22.05537876
7ERBB412.8112933
8LRRK21.94730082
9MET1.73784735
10LATS21.69441387
11FGFR41.69317563
12KSR21.68837841
13MAP3K61.62728290
14STK38L1.61210902
15MAP3K21.56321424
16NLK1.54222636
17MAPK151.52941554
18NEK61.47229902
19MAP3K91.47048125
20PRKAA21.44483396
21NME21.39049596
22RIPK41.37924037
23MAP2K21.36106503
24MAPK71.33411532
25MAPK121.31128585
26LATS11.30807333
27PIK3CG1.30067101
28AKT31.28604622
29MAP2K11.27152807
30FER1.22404148
31STK101.21488556
32BRD41.15851286
33STK381.15274877
34PRPF4B1.15096622
35PTK61.11298570
36IRAK11.08111587
37ERN11.04141580
38LMTK21.03113255
39PRKG20.99441572
40MAPK40.98514121
41BCKDK0.96267936
42RIPK10.93162478
43PRKCI0.92720021
44FGFR30.91823583
45GSK3A0.89597583
46NME10.89587950
47PAK30.87353937
48JAK10.86534974
49MAP3K140.86351852
50TYK20.82003231
51NEK10.81578004
52TESK10.80593503
53STK390.79598512
54NEK90.79428662
55MYLK0.78408038
56FYN0.77665848
57MAP3K130.77582351
58NUAK10.76371992
59PAK40.75624054
60TAOK10.74155427
61WNK40.73974592
62FRK0.73055955
63DDR20.72084737
64JAK20.72007040
65PDGFRB0.69909770
66RPS6KB20.68066858
67PBK0.67724599
68GRK50.67545132
69YES10.67427925
70ROCK20.66057930
71ICK0.63830662
72CDC42BPA0.62402849
73MAP3K80.60286320
74DAPK20.60283011
75MAPK30.57915362
76ABL20.57665700
77BMX0.57177996
78KIT0.57010443
79TRPM70.54320363
80MARK20.53751393
81PTK20.53552613
82MAP3K30.53285187
83SGK30.52400015
84HIPK20.52316163
85ZAP700.52136741
86PDK40.51651902
87PDK30.51651902
88EPHB10.51100025
89CAMK1D0.49902248
90JAK30.49533011
91SRC0.49394308
92KDR0.46912528
93ARAF0.46608634
94MOS0.46459058
95RET0.45881587
96TYRO30.44708990
97CDK60.44549062
98SGK20.44339966
99MTOR0.43901485
100PDPK10.43231321
101ERBB20.43073143
102RPS6KA20.42600263
103INSR0.42256581
104STK240.42111752
105EEF2K0.42083126
106MAPKAPK30.41664801
107FES0.40798926
108SIK10.40654830
109MAP3K70.39900265
110GRK10.39836725
111MATK0.39786388
112CDK190.39645734
113IGF1R0.38882420
114BLK0.38760990
115ROCK10.38627876
116LIMK10.36922043
117MAPK10.36843149
118WNK10.36420794
119MAP3K10.36388585
120CAMKK20.34868607
121MAP3K110.31488294
122TTN0.31197904
123CAMKK10.30758985
124ILK0.30599768
125GRK60.30402781
126CAMK2B0.30224111
127PDK20.30154813
128MAP3K100.30044657
129SCYL20.28763161
130TIE10.28747005
131DMPK0.28242509
132PDK10.28204470
133DAPK30.28068298
134CSK0.27264065
135CAMK2G0.25011800
136EGFR0.24991775
137PDGFRA0.23975270
138CAMK2D0.23466678
139ALK0.23018819
140PRKD10.23005292
141FGR0.22406778
142NTRK10.21859806
143PIM20.21245241
144MINK10.19966921
145EPHB20.18781273
146PAK10.18126779
147PRKCQ0.15975278
148TBK10.15163436
149KSR10.14914871
150RAF10.13867972
151ADRBK10.13421524
152RPS6KA10.11662039
153PHKG10.11407680
154PHKG20.11407680
155PAK60.11387499
156PAK20.10954048
157EPHA20.10222646

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.41097243
2Gastric acid secretion_Homo sapiens_hsa049714.66913387
3Sulfur metabolism_Homo sapiens_hsa009204.66635169
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.33563121
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.33244867
6Collecting duct acid secretion_Homo sapiens_hsa049663.98356820
7Chemical carcinogenesis_Homo sapiens_hsa052043.81308159
8Glutathione metabolism_Homo sapiens_hsa004803.53879266
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.96980566
10Pertussis_Homo sapiens_hsa051332.81523166
11Fatty acid biosynthesis_Homo sapiens_hsa000612.63331656
12Complement and coagulation cascades_Homo sapiens_hsa046102.56085723
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.41786649
14Fat digestion and absorption_Homo sapiens_hsa049752.37082863
15Protein digestion and absorption_Homo sapiens_hsa049742.29628416
16Staphylococcus aureus infection_Homo sapiens_hsa051502.23861432
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97381750
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85365413
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82500441
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.78989427
21Vitamin digestion and absorption_Homo sapiens_hsa049771.72924061
22Linoleic acid metabolism_Homo sapiens_hsa005911.60594051
23Phagosome_Homo sapiens_hsa041451.54550005
24Nitrogen metabolism_Homo sapiens_hsa009101.43865359
25Mineral absorption_Homo sapiens_hsa049781.34488800
26Ether lipid metabolism_Homo sapiens_hsa005651.32900745
27Malaria_Homo sapiens_hsa051441.27244533
28Selenocompound metabolism_Homo sapiens_hsa004501.25939165
29Pancreatic secretion_Homo sapiens_hsa049721.25551606
30Ovarian steroidogenesis_Homo sapiens_hsa049131.25334186
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24588142
32Fatty acid degradation_Homo sapiens_hsa000711.23484208
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19772556
34Retinol metabolism_Homo sapiens_hsa008301.14391196
35Asthma_Homo sapiens_hsa053101.12945944
36Other glycan degradation_Homo sapiens_hsa005111.12237882
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11360550
38Circadian rhythm_Homo sapiens_hsa047101.09798469
39Viral myocarditis_Homo sapiens_hsa054161.05268576
40Sulfur relay system_Homo sapiens_hsa041221.03679288
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00844172
42Thyroid hormone synthesis_Homo sapiens_hsa049180.97982070
43Oxidative phosphorylation_Homo sapiens_hsa001900.92982700
44Hepatitis C_Homo sapiens_hsa051600.92777278
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91892635
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91337446
47Insulin resistance_Homo sapiens_hsa049310.90845658
48Graft-versus-host disease_Homo sapiens_hsa053320.89025448
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87767765
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.87422727
51Rheumatoid arthritis_Homo sapiens_hsa053230.85176999
52Autoimmune thyroid disease_Homo sapiens_hsa053200.84748121
53Pyruvate metabolism_Homo sapiens_hsa006200.84413007
54Propanoate metabolism_Homo sapiens_hsa006400.84400657
55Phenylalanine metabolism_Homo sapiens_hsa003600.81102426
56Bile secretion_Homo sapiens_hsa049760.79955586
57Leishmaniasis_Homo sapiens_hsa051400.79925200
58Allograft rejection_Homo sapiens_hsa053300.77472786
59Glycerolipid metabolism_Homo sapiens_hsa005610.76554247
60Prion diseases_Homo sapiens_hsa050200.74418495
61Toxoplasmosis_Homo sapiens_hsa051450.74030565
62Histidine metabolism_Homo sapiens_hsa003400.74015726
63TNF signaling pathway_Homo sapiens_hsa046680.71477207
64Carbon metabolism_Homo sapiens_hsa012000.71420548
65Insulin signaling pathway_Homo sapiens_hsa049100.71338199
66Butanoate metabolism_Homo sapiens_hsa006500.70849600
67Renin secretion_Homo sapiens_hsa049240.70170572
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68531512
69Tight junction_Homo sapiens_hsa045300.68075571
70Notch signaling pathway_Homo sapiens_hsa043300.67689060
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65068178
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64705549
73beta-Alanine metabolism_Homo sapiens_hsa004100.63587650
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63098445
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62661848
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62069509
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61783539
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.60444963
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.58680818
80Renal cell carcinoma_Homo sapiens_hsa052110.57507161
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.57266174
82Amoebiasis_Homo sapiens_hsa051460.56690278
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56616723
84Fatty acid metabolism_Homo sapiens_hsa012120.56287653
85Osteoclast differentiation_Homo sapiens_hsa043800.56093415
86Influenza A_Homo sapiens_hsa051640.55820482
87Thyroid cancer_Homo sapiens_hsa052160.52923434
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52400353
89AMPK signaling pathway_Homo sapiens_hsa041520.52225210
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51947054
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.51846094
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49160905
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48707368
94Arginine biosynthesis_Homo sapiens_hsa002200.48308059
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47358856
96Dorso-ventral axis formation_Homo sapiens_hsa043200.47236484
97Sphingolipid metabolism_Homo sapiens_hsa006000.46171881
98Lysosome_Homo sapiens_hsa041420.45752021
99PPAR signaling pathway_Homo sapiens_hsa033200.45432217
100Vibrio cholerae infection_Homo sapiens_hsa051100.45348070
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.45296877
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45199382
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.44097686
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.43554121
105Pentose phosphate pathway_Homo sapiens_hsa000300.42523352
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41174656
107Arachidonic acid metabolism_Homo sapiens_hsa005900.39213591
108Tuberculosis_Homo sapiens_hsa051520.37843054
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.37694968
110TGF-beta signaling pathway_Homo sapiens_hsa043500.37349161
111Tyrosine metabolism_Homo sapiens_hsa003500.36975664
112Fructose and mannose metabolism_Homo sapiens_hsa000510.36194619
113Bladder cancer_Homo sapiens_hsa052190.34328415
114Choline metabolism in cancer_Homo sapiens_hsa052310.33019789
115Antigen processing and presentation_Homo sapiens_hsa046120.32541931
116Dilated cardiomyopathy_Homo sapiens_hsa054140.32386575
117Adherens junction_Homo sapiens_hsa045200.32376044
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32278242
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31926068
120Arginine and proline metabolism_Homo sapiens_hsa003300.31805511
121Shigellosis_Homo sapiens_hsa051310.30795133
122Salmonella infection_Homo sapiens_hsa051320.29507772
123Folate biosynthesis_Homo sapiens_hsa007900.29097326
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.26848142
125Cardiac muscle contraction_Homo sapiens_hsa042600.25990070
126Galactose metabolism_Homo sapiens_hsa000520.24882196
127Alzheimers disease_Homo sapiens_hsa050100.24298933
128Proteoglycans in cancer_Homo sapiens_hsa052050.23922213
129Tryptophan metabolism_Homo sapiens_hsa003800.23448638
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23326422
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23313088
132Salivary secretion_Homo sapiens_hsa049700.21264686
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20629521
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17731066
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17495890
136ECM-receptor interaction_Homo sapiens_hsa045120.15688778
137Focal adhesion_Homo sapiens_hsa045100.15503965
138Biosynthesis of amino acids_Homo sapiens_hsa012300.14832915
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12893362
140Estrogen signaling pathway_Homo sapiens_hsa049150.12016175
141Starch and sucrose metabolism_Homo sapiens_hsa005000.11528459
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.11296841
143VEGF signaling pathway_Homo sapiens_hsa043700.10811824
144Peroxisome_Homo sapiens_hsa041460.09927881
145Metabolic pathways_Homo sapiens_hsa011000.09917403
146ABC transporters_Homo sapiens_hsa020100.08399453
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.07842894
148GnRH signaling pathway_Homo sapiens_hsa049120.07225678
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06647382
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.06462585
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.06209820
152Fatty acid elongation_Homo sapiens_hsa000620.05954890
153Platelet activation_Homo sapiens_hsa046110.05574387

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